NO20080871L - N-(Heteroaryl)-1-heteroarylalkyl-1 H-indol-2-karboksamidderivater, fremstilling og terapeutisk anvendelse derav - Google Patents

N-(Heteroaryl)-1-heteroarylalkyl-1 H-indol-2-karboksamidderivater, fremstilling og terapeutisk anvendelse derav

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Publication number
NO20080871L
NO20080871L NO20080871A NO20080871A NO20080871L NO 20080871 L NO20080871 L NO 20080871L NO 20080871 A NO20080871 A NO 20080871A NO 20080871 A NO20080871 A NO 20080871A NO 20080871 L NO20080871 L NO 20080871L
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Norway
Prior art keywords
heteroaryl
alkyl
preparation
therapeutic use
heteroarylalkyl
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NO20080871A
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English (en)
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Laurent Dubois
Andre Malanda
Yannick Evanno
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Sanofi Aventis
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Publication of NO20080871L publication Critical patent/NO20080871L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
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Abstract

Foreliggende oppfinnelse angår forbindelser med generell formel (I). hvori: Xi, X, Xog Xrepresenterer, uavhengig av hverandre, et hydrogen eller halogenatom eller en C-C-alkyl, C-C-cykloalkyl, C3-C7-cykloalkyl-Ci -C3-alkylen, C-C-fiuoroalkyl, C-C-alkoksy, C-C-fiuoroalkoksy, cyano, C(0)NRR, nitro, NRR, C-C-tioalkyl, -S(0)-C-C-alkyl, -S(0)2-C-C-alkyl, SO^R,, NRCOR, NRS0Reller arylgnippe, hvori arylet værende eventuelt substituert;. W representerer en sammensmeltet bicyklisk gruppe med formel (II): bundet til nitrogenatomet via posisjoner 1, 2, 3 eller 4; A representerer et 5- til 7-leddet heterocykel som innbefatter fra en til tre heteroatomer valgt fra 0, S og N; karbonatomene til A er eventuelt substituert; n er lik 1, 2 eller 3; Y representerer et heteroaryl i base- eller syreaddisjonssaltform. Oppfinnelsen angår også en fremgangmåte for fremstilling av nevnte forbindelser og deres terapeutiske anvendelse.
NO20080871A 2005-07-22 2008-02-19 N-(Heteroaryl)-1-heteroarylalkyl-1 H-indol-2-karboksamidderivater, fremstilling og terapeutisk anvendelse derav NO20080871L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507803A FR2888847B1 (fr) 2005-07-22 2005-07-22 Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
PCT/FR2006/001782 WO2007010144A1 (fr) 2005-07-22 2006-07-20 Dérivés de n-(hétéroaryl)-1-hétéroarylalkyl-1h-indole-2-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
NO20080871L true NO20080871L (no) 2008-02-19

Family

ID=36156910

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080871A NO20080871L (no) 2005-07-22 2008-02-19 N-(Heteroaryl)-1-heteroarylalkyl-1 H-indol-2-karboksamidderivater, fremstilling og terapeutisk anvendelse derav

Country Status (27)

Country Link
US (3) US7745467B2 (no)
EP (1) EP1910335B1 (no)
JP (1) JP5281890B2 (no)
KR (1) KR20080027864A (no)
CN (1) CN101228152B (no)
AR (1) AR054857A1 (no)
AU (1) AU2006271524B2 (no)
BR (1) BRPI0613758A2 (no)
CA (1) CA2615751C (no)
CR (1) CR9590A (no)
EA (1) EA013748B1 (no)
EC (1) ECSP088084A (no)
FR (1) FR2888847B1 (no)
HK (1) HK1123050A1 (no)
IL (1) IL188643A (no)
MA (1) MA29698B1 (no)
MX (1) MX2008001019A (no)
MY (1) MY146545A (no)
NI (1) NI200800015A (no)
NO (1) NO20080871L (no)
NZ (1) NZ565148A (no)
TN (1) TNSN07469A1 (no)
TW (1) TWI386402B (no)
UA (1) UA93687C2 (no)
UY (1) UY29690A1 (no)
WO (1) WO2007010144A1 (no)
ZA (1) ZA200800438B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
EP2079466B1 (en) * 2006-09-29 2014-01-15 GlaxoSmithKline LLC Substituted indole compounds
FR2911604B1 (fr) 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2911605B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique
FR2919610B1 (fr) * 2007-08-02 2009-10-16 Sanofi Aventis Sa Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
SG183699A1 (en) * 2007-08-10 2012-09-27 Lundbeck & Co As H Heteroaryl amide analogues
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926553B1 (fr) 2008-01-23 2010-02-19 Sanofi Aventis Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique
US8309581B2 (en) * 2009-09-29 2012-11-13 Hoffmann-La Roche Inc. Benzimidazole derivatives
JP6331882B2 (ja) * 2014-08-28 2018-05-30 ソニー株式会社 送信装置、送信方法、受信装置および受信方法
US20230043159A1 (en) * 2018-10-02 2023-02-09 Disc Medicine, Inc. Matriptase 2 inhibitors and uses thereof
WO2024026290A1 (en) * 2022-07-25 2024-02-01 Cayman Chemical Company Incorporated NOVEL HETEROCYCLES AS sPLA2-X INHIBITORS

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
DE10147672A1 (de) 2001-09-27 2003-04-10 Bayer Ag Substituierte 2,5-Diamidoindole und ihre Verwendung
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
EP2033953A1 (en) * 2002-02-15 2009-03-11 Glaxo Group Limited Vanilloid receptor modulators
US20060183753A1 (en) 2002-12-20 2006-08-17 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
US7531558B2 (en) * 2003-02-14 2009-05-12 Glaxo Group Limited Carboxamide derivatives
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2888848B1 (fr) 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2911604B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CA2615751A1 (fr) 2007-01-25
CA2615751C (fr) 2013-12-17
EP1910335A1 (fr) 2008-04-16
IL188643A0 (en) 2008-04-13
US8735432B2 (en) 2014-05-27
FR2888847A1 (fr) 2007-01-26
MA29698B1 (fr) 2008-08-01
TWI386402B (zh) 2013-02-21
KR20080027864A (ko) 2008-03-28
ECSP088084A (es) 2008-02-20
US20080146646A1 (en) 2008-06-19
EA013748B1 (ru) 2010-06-30
NZ565148A (en) 2011-03-31
NI200800015A (es) 2010-12-17
IL188643A (en) 2013-05-30
AU2006271524B2 (en) 2012-04-12
US20130046095A1 (en) 2013-02-21
AU2006271524A1 (en) 2007-01-25
US20100222368A1 (en) 2010-09-02
WO2007010144A1 (fr) 2007-01-25
EP1910335B1 (fr) 2013-11-06
EA200800403A1 (ru) 2008-06-30
JP5281890B2 (ja) 2013-09-04
TW200732322A (en) 2007-09-01
UA93687C2 (en) 2011-03-10
US7745467B2 (en) 2010-06-29
HK1123050A1 (no) 2009-06-05
UY29690A1 (es) 2007-02-28
CR9590A (es) 2008-03-06
BRPI0613758A2 (pt) 2011-02-08
JP2009502767A (ja) 2009-01-29
AR054857A1 (es) 2007-07-18
US8318775B2 (en) 2012-11-27
FR2888847B1 (fr) 2007-08-31
CN101228152B (zh) 2012-12-12
ZA200800438B (en) 2009-04-29
CN101228152A (zh) 2008-07-23
TNSN07469A1 (en) 2009-03-17
MX2008001019A (es) 2008-03-14
MY146545A (en) 2012-08-15

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