EA200800403A1 - Производные n-(гетероарил)-1-гетероарилалкил-1н-индол-2-карбоксамидов, их получение и их применение в терапии - Google Patents

Производные n-(гетероарил)-1-гетероарилалкил-1н-индол-2-карбоксамидов, их получение и их применение в терапии

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Publication number
EA200800403A1
EA200800403A1 EA200800403A EA200800403A EA200800403A1 EA 200800403 A1 EA200800403 A1 EA 200800403A1 EA 200800403 A EA200800403 A EA 200800403A EA 200800403 A EA200800403 A EA 200800403A EA 200800403 A1 EA200800403 A1 EA 200800403A1
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Eurasian Patent Office
Prior art keywords
alkyl
optionally substituted
therapy
heteroarilal
heteroaril
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EA200800403A
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English (en)
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EA013748B1 (ru
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Лоран Дюбуа
Янник Эванно
Андре Маланда
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Санофи-Авентис
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Publication of EA200800403A1 publication Critical patent/EA200800403A1/ru
Publication of EA013748B1 publication Critical patent/EA013748B1/ru

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

Изобретение относится к соединениям общей формулы (I), в которых X, X, Х, Хозначают, независимо друг от друга, атом водорода или галогена или (C-C)-алкил, (С-С)-циклоалкил, (С-С)-циклоалкил-(C-С)-алкилен, (C-C)-фторалкил, (C-C)-алкоксил, (C-С)-фторалкоксил, цианогруппу, C(O)NRR, нитрогруппу, NRR, (C-C)-тиоалкил, -S(О)-(C-С)-алкил, -S(О)-(C-C)-алкил, SONRR, NRCOR, NRSORили арил, причем арил возможно замещен; W означает бициклическую конденсированную группу формулы (II), связанную с атомом азота в положениях 1, 2, 3 или 4; А означает 5-7-членный гетероцикл, включающий от одного до трех гетероатомов, выбираемых среди О, S или N; причем атом или атомы углеродов А возможно замещены; атом или атомы азота А возможно замещены; n равно 1, 2 или 3; Y означает возможно замещенный гетероарил; в форме основания или аддитивной соли с кислотой, а также в форме гидрата или сольвата; способу получения и применению в терапии.
EA200800403A 2005-07-22 2006-07-20 Производные n-(гетероарил)-1-гетероарилалкил-1h-индол-2-карбоксамидов, их получение и их применение в терапии EA013748B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507803A FR2888847B1 (fr) 2005-07-22 2005-07-22 Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
PCT/FR2006/001782 WO2007010144A1 (fr) 2005-07-22 2006-07-20 Dérivés de n-(hétéroaryl)-1-hétéroarylalkyl-1h-indole-2-carboxamides, leur préparation et leur application en thérapeutique

Publications (2)

Publication Number Publication Date
EA200800403A1 true EA200800403A1 (ru) 2008-06-30
EA013748B1 EA013748B1 (ru) 2010-06-30

Family

ID=36156910

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Application Number Title Priority Date Filing Date
EA200800403A EA013748B1 (ru) 2005-07-22 2006-07-20 Производные n-(гетероарил)-1-гетероарилалкил-1h-индол-2-карбоксамидов, их получение и их применение в терапии

Country Status (27)

Country Link
US (3) US7745467B2 (ru)
EP (1) EP1910335B1 (ru)
JP (1) JP5281890B2 (ru)
KR (1) KR20080027864A (ru)
CN (1) CN101228152B (ru)
AR (1) AR054857A1 (ru)
AU (1) AU2006271524B2 (ru)
BR (1) BRPI0613758A2 (ru)
CA (1) CA2615751C (ru)
CR (1) CR9590A (ru)
EA (1) EA013748B1 (ru)
EC (1) ECSP088084A (ru)
FR (1) FR2888847B1 (ru)
HK (1) HK1123050A1 (ru)
IL (1) IL188643A (ru)
MA (1) MA29698B1 (ru)
MX (1) MX2008001019A (ru)
MY (1) MY146545A (ru)
NI (1) NI200800015A (ru)
NO (1) NO20080871L (ru)
NZ (1) NZ565148A (ru)
TN (1) TNSN07469A1 (ru)
TW (1) TWI386402B (ru)
UA (1) UA93687C2 (ru)
UY (1) UY29690A1 (ru)
WO (1) WO2007010144A1 (ru)
ZA (1) ZA200800438B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
ES2452343T3 (es) * 2006-09-29 2014-04-01 Glaxosmithkline Llc Compuestos de indol sustituidos
FR2911604B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2911605B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique
FR2919610B1 (fr) * 2007-08-02 2009-10-16 Sanofi Aventis Sa Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
KR20100066422A (ko) * 2007-08-10 2010-06-17 하. 룬트벡 아크티에 셀스카브 헤테로아릴 아미드 유사체
FR2926554B1 (fr) * 2008-01-22 2010-03-12 Sanofi Aventis Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926556B1 (fr) * 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926555B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926553B1 (fr) * 2008-01-23 2010-02-19 Sanofi Aventis Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique
US8309581B2 (en) * 2009-09-29 2012-11-13 Hoffmann-La Roche Inc. Benzimidazole derivatives
JP6331882B2 (ja) * 2014-08-28 2018-05-30 ソニー株式会社 送信装置、送信方法、受信装置および受信方法
WO2024026290A1 (en) * 2022-07-25 2024-02-01 Cayman Chemical Company Incorporated NOVEL HETEROCYCLES AS sPLA2-X INHIBITORS

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
SE9903998D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
DE10147672A1 (de) 2001-09-27 2003-04-10 Bayer Ag Substituierte 2,5-Diamidoindole und ihre Verwendung
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
TW200403223A (en) * 2002-02-15 2004-03-01 Glaxo Group Ltd Novel compounds
EP1578418A2 (en) 2002-12-20 2005-09-28 Bayer HealthCare AG Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
JP4909068B2 (ja) * 2003-02-14 2012-04-04 グラクソ グループ リミテッド カルボキサミド誘導体
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
FR2874015B1 (fr) * 2004-08-05 2006-09-15 Sanofi Synthelabo Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888848B1 (fr) 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2911604B1 (fr) * 2007-01-19 2009-04-17 Sanofi Aventis Sa Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
BRPI0613758A2 (pt) 2011-02-08
FR2888847B1 (fr) 2007-08-31
MX2008001019A (es) 2008-03-14
CN101228152A (zh) 2008-07-23
EP1910335A1 (fr) 2008-04-16
US8318775B2 (en) 2012-11-27
CR9590A (es) 2008-03-06
JP5281890B2 (ja) 2013-09-04
AU2006271524A1 (en) 2007-01-25
CA2615751A1 (fr) 2007-01-25
AU2006271524B2 (en) 2012-04-12
HK1123050A1 (ru) 2009-06-05
JP2009502767A (ja) 2009-01-29
NI200800015A (es) 2010-12-17
EA013748B1 (ru) 2010-06-30
TWI386402B (zh) 2013-02-21
KR20080027864A (ko) 2008-03-28
US8735432B2 (en) 2014-05-27
NZ565148A (en) 2011-03-31
CA2615751C (fr) 2013-12-17
ZA200800438B (en) 2009-04-29
US20130046095A1 (en) 2013-02-21
TNSN07469A1 (en) 2009-03-17
CN101228152B (zh) 2012-12-12
US7745467B2 (en) 2010-06-29
MY146545A (en) 2012-08-15
MA29698B1 (fr) 2008-08-01
US20080146646A1 (en) 2008-06-19
FR2888847A1 (fr) 2007-01-26
AR054857A1 (es) 2007-07-18
UY29690A1 (es) 2007-02-28
US20100222368A1 (en) 2010-09-02
WO2007010144A1 (fr) 2007-01-25
TW200732322A (en) 2007-09-01
IL188643A (en) 2013-05-30
IL188643A0 (en) 2008-04-13
NO20080871L (no) 2008-02-19
ECSP088084A (es) 2008-02-20
EP1910335B1 (fr) 2013-11-06
UA93687C2 (en) 2011-03-10

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