UA113668C2 - Спосіб одержання високочистої калієвої солі азилсартану медоксомілу - Google Patents
Спосіб одержання високочистої калієвої солі азилсартану медоксомілуInfo
- Publication number
- UA113668C2 UA113668C2 UAA201503960A UAA201503960A UA113668C2 UA 113668 C2 UA113668 C2 UA 113668C2 UA A201503960 A UAA201503960 A UA A201503960A UA A201503960 A UAA201503960 A UA A201503960A UA 113668 C2 UA113668 C2 UA 113668C2
- Authority
- UA
- Ukraine
- Prior art keywords
- potassium salt
- preparing
- azilsartan medoxomil
- highly pure
- pure potassium
- Prior art date
Links
- 239000003861 C09CA09 - Azilsartan medoxomil Substances 0.000 title abstract 3
- 229960001211 azilsartan medoxomil Drugs 0.000 title abstract 3
- QJFSABGVXDWMIW-UHFFFAOYSA-N azilsartan medoxomil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C=3NC(=O)ON=3)C(OCC)=NC2=CC=CC=1C(=O)OCC=1OC(=O)OC=1C QJFSABGVXDWMIW-UHFFFAOYSA-N 0.000 title abstract 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 abstract 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 2
- 229940113088 dimethylacetamide Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 abstract 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 1
- AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2012-663A CZ305318B6 (cs) | 2012-09-26 | 2012-09-26 | Způsob přípravy vysoce čisté draselné soli azilsartanu medoxomilu |
| PCT/CZ2013/000114 WO2014048404A1 (en) | 2012-09-26 | 2013-09-25 | A method of preparing a highly pure potassium salt of azilsartan medoxomil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA113668C2 true UA113668C2 (uk) | 2017-02-27 |
Family
ID=66624776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201503960A UA113668C2 (uk) | 2012-09-26 | 2013-09-25 | Спосіб одержання високочистої калієвої солі азилсартану медоксомілу |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2900662A1 (cs) |
| JP (1) | JP2015532267A (cs) |
| KR (1) | KR20150060733A (cs) |
| CN (1) | CN104662019A (cs) |
| BR (1) | BR112015006572A2 (cs) |
| CZ (1) | CZ305318B6 (cs) |
| EA (1) | EA028171B1 (cs) |
| HK (1) | HK1205505A1 (cs) |
| IL (1) | IL237884A0 (cs) |
| MX (1) | MX2015003209A (cs) |
| UA (1) | UA113668C2 (cs) |
| WO (1) | WO2014048404A1 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2014702A3 (cs) * | 2014-10-15 | 2016-04-27 | Zentiva, K.S. | Způsob přípravy vysoce čistého azilsartanu |
| CN105753854A (zh) * | 2014-12-16 | 2016-07-13 | 重庆朗天制药有限公司 | 一种阿齐沙坦酯钾盐的新制备方法 |
| CN109071519A (zh) * | 2016-01-28 | 2018-12-21 | 株式会社德山 | 阿齐沙坦及其制造方法 |
| CN108727356A (zh) * | 2018-06-28 | 2018-11-02 | 江苏新瑞药业有限公司 | 一种奥美沙坦酯碱金属盐的合成方法 |
| CN115894472B (zh) * | 2022-12-14 | 2025-08-19 | 仁合益康集团有限公司 | 一种高纯度阿齐沙坦酯钾盐的制备方法 |
| CN117126150A (zh) * | 2023-08-29 | 2023-11-28 | 仁合益康集团有限公司 | 一种阿齐沙坦酯钾盐杂质a的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| WO2012090043A1 (en) * | 2010-12-29 | 2012-07-05 | Jubilant Life Sciences Limited | Novel solid state forms of azilsartan medoxomil and preparation thereof |
| US9233955B2 (en) * | 2011-02-08 | 2016-01-12 | Jubilant Life Sciences, Ltd. | Process for the preparation of azilsartan medoxomil |
| WO2013042067A1 (en) * | 2011-09-20 | 2013-03-28 | Ranbaxy Laboratories Limited | Process for the preparation of potassium salt of azilsartan medoxomil |
| WO2013104342A1 (en) * | 2012-01-14 | 2013-07-18 | Sunshine Lake Pharma Co., Ltd. | Crystalline forms of azilsartan medoxomil potassium and preparation and uses thereof |
| CZ2012274A3 (cs) * | 2012-04-19 | 2013-10-30 | Zentiva, K.S. | Zpusob prípravy vysoce cisté draselné soli azilsartanu medoxomilu |
-
2012
- 2012-09-26 CZ CZ2012-663A patent/CZ305318B6/cs not_active IP Right Cessation
-
2013
- 2013-09-25 MX MX2015003209A patent/MX2015003209A/es unknown
- 2013-09-25 JP JP2015533448A patent/JP2015532267A/ja active Pending
- 2013-09-25 KR KR1020157007800A patent/KR20150060733A/ko not_active Withdrawn
- 2013-09-25 EA EA201590657A patent/EA028171B1/ru not_active IP Right Cessation
- 2013-09-25 CN CN201380050044.9A patent/CN104662019A/zh active Pending
- 2013-09-25 UA UAA201503960A patent/UA113668C2/uk unknown
- 2013-09-25 EP EP13779507.6A patent/EP2900662A1/en not_active Withdrawn
- 2013-09-25 HK HK15106026.8A patent/HK1205505A1/xx unknown
- 2013-09-25 WO PCT/CZ2013/000114 patent/WO2014048404A1/en active Application Filing
- 2013-09-25 BR BR112015006572A patent/BR112015006572A2/pt not_active IP Right Cessation
-
2015
- 2015-03-22 IL IL237884A patent/IL237884A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015532267A (ja) | 2015-11-09 |
| EA201590657A1 (ru) | 2015-08-31 |
| EP2900662A1 (en) | 2015-08-05 |
| IL237884A0 (en) | 2015-05-31 |
| CZ2012663A3 (cs) | 2014-04-02 |
| MX2015003209A (es) | 2015-07-14 |
| KR20150060733A (ko) | 2015-06-03 |
| CZ305318B6 (cs) | 2015-07-29 |
| CN104662019A (zh) | 2015-05-27 |
| WO2014048404A1 (en) | 2014-04-03 |
| HK1205505A1 (en) | 2015-12-18 |
| EA028171B1 (ru) | 2017-10-31 |
| BR112015006572A2 (pt) | 2017-07-04 |
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