UA103316C2 - Вакцини на базі флавівірусів з дефектною реплікацією і вектори для одержання вакцин - Google Patents
Вакцини на базі флавівірусів з дефектною реплікацією і вектори для одержання вакцинInfo
- Publication number
- UA103316C2 UA103316C2 UAA201012164A UAA201012164A UA103316C2 UA 103316 C2 UA103316 C2 UA 103316C2 UA A201012164 A UAA201012164 A UA A201012164A UA A201012164 A UAA201012164 A UA A201012164A UA 103316 C2 UA103316 C2 UA 103316C2
- Authority
- UA
- Ukraine
- Prior art keywords
- replication
- vaccine vectors
- flavivirus vaccines
- defective flavivirus
- defective
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
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- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24141—Use of virus, viral particle or viral elements as a vector
- C12N2770/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Винахід належить до вакцини на базі флавівірусів з дефектною реплікацією і векторів для одержання зазначеної вакцини, а також до відповідної композиції і способу індукування імунної реакції.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6945108P | 2008-03-14 | 2008-03-14 | |
US9281408P | 2008-08-29 | 2008-08-29 | |
PCT/US2009/001666 WO2009114207A2 (en) | 2008-03-14 | 2009-03-16 | Replication-defective flavivirus vaccines and vaccine vectors |
Publications (1)
Publication Number | Publication Date |
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UA103316C2 true UA103316C2 (uk) | 2013-10-10 |
Family
ID=41065743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201012164A UA103316C2 (uk) | 2008-03-14 | 2009-03-16 | Вакцини на базі флавівірусів з дефектною реплікацією і вектори для одержання вакцин |
Country Status (16)
Country | Link |
---|---|
US (2) | US8815564B2 (uk) |
EP (1) | EP2265284A4 (uk) |
JP (1) | JP5779352B2 (uk) |
KR (1) | KR101719316B1 (uk) |
CN (2) | CN105039266A (uk) |
AU (1) | AU2009223727B2 (uk) |
BR (1) | BRPI0908936A2 (uk) |
CA (1) | CA2717499A1 (uk) |
EA (2) | EA201591888A1 (uk) |
HK (1) | HK1162306A1 (uk) |
IL (1) | IL208147A (uk) |
MX (1) | MX2010010034A (uk) |
SG (1) | SG188891A1 (uk) |
UA (1) | UA103316C2 (uk) |
WO (1) | WO2009114207A2 (uk) |
ZA (1) | ZA201006437B (uk) |
Families Citing this family (40)
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WO2009003492A1 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
EP2069483A4 (en) * | 2006-09-29 | 2010-10-27 | Sanofi Pasteur Biologics Co | RECOMBINANT RHINOVIRAL VECTORS |
EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
EP2197908A2 (en) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
CN105039266A (zh) * | 2008-03-14 | 2015-11-11 | 赛诺菲巴斯德生物制剂有限责任公司 | 复制缺陷型黄病毒疫苗和疫苗载体 |
EP2257308A4 (en) * | 2008-03-27 | 2012-06-27 | Sanofi Pasteur Biologics Co | RECOMBINANT RHINOVIRUS VECTORS |
WO2010009735A2 (en) | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
WO2010037402A1 (en) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Molecular vaccines for infectious disease |
CA2755257A1 (en) * | 2009-03-16 | 2010-09-23 | Sanofi Pasteur Biologics Co. | Replication-defective flavivirus vaccine vectors against respiratory syncytial virus |
CN107126557A (zh) * | 2009-06-29 | 2017-09-05 | 健诺西生物科学公司 | 抗肺炎链球菌的疫苗和组合物 |
BRPI0914507A2 (pt) * | 2009-12-23 | 2012-04-10 | Fundacao Oswaldo Cruz | vacina para lentivìrus baseada em vìrus recombinante vacinal da febre amarela |
US10238734B2 (en) * | 2010-03-23 | 2019-03-26 | The Regents Of The University Of California | Compositions and methods for self-adjuvanting vaccines against microbes and tumors |
WO2011119716A2 (en) * | 2010-03-24 | 2011-09-29 | Research Development Foundation | Flavivirus host range mutations and uses thereof |
WO2012003320A2 (en) | 2010-07-01 | 2012-01-05 | Research Development Foundation | Flavivirus host-range mutations and uses thereof |
AU2012207089B2 (en) | 2011-01-20 | 2016-04-14 | Children's Medical Center Corporation | Vaccines and compositions against Streptococcus pneumoniae |
CN102181408A (zh) * | 2011-01-30 | 2011-09-14 | 中国检验检疫科学研究院 | 圣路易斯脑炎病毒样颗粒的制备方法及其应用 |
CA2836501A1 (en) | 2011-07-12 | 2013-01-17 | Gwong-Jen J. Chang | Identification of a west nile virus cd4 t cell epitope and use thereof |
WO2013106337A1 (en) * | 2012-01-09 | 2013-07-18 | Sanofi Pasteur Biologics, Llc | Purification of flaviviruses |
WO2013116770A1 (en) * | 2012-02-01 | 2013-08-08 | Sanofi Pasteur Biologics, Llc | Replication-defective flavivirus vaccines and vaccine vectors |
WO2013138670A1 (en) * | 2012-03-15 | 2013-09-19 | Icahn School Of Medicine At Mount Sinai | Yellow fever virus ns5 mutants as flavivirus vaccine candidates |
WO2013138776A1 (en) * | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
US8895028B2 (en) * | 2012-07-20 | 2014-11-25 | Arbovax, Inc. | Methods and compositions for dengue virus 3 (DV3) infectious clone |
US20140271708A1 (en) * | 2013-03-15 | 2014-09-18 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies G |
SG11201607287XA (en) * | 2014-03-01 | 2016-09-29 | Univ Texas | Recombinant isfahan viral vectors |
EP3158061B1 (en) | 2014-06-20 | 2019-08-07 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Chimeric west nile/dengue viruses and methods of use |
EP3031923A1 (en) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
BR112017025954A2 (pt) * | 2015-06-02 | 2018-08-14 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport | apresentação em superfície de antígenos em vesículas de membrana externa gram-negativa |
WO2018060771A1 (en) | 2016-09-30 | 2018-04-05 | Sanofi Pasteur | Live attenuated chimeric zika virus and its use as an immunogenic composition |
SG11201908280SA (en) | 2017-03-30 | 2019-10-30 | Univ Queensland | "chimeric molecules and uses thereof" |
WO2018231690A1 (en) * | 2017-06-12 | 2018-12-20 | Washington University | Zika virus strains for treatment of glioblastoma |
WO2019040994A1 (en) | 2017-09-01 | 2019-03-07 | The Australian National University | IMMUNOREGULATOR MOLECULES AND USES THEREOF |
GB201716254D0 (en) * | 2017-10-05 | 2017-11-22 | Univ Leuven Kath | Live-attenuated flaviruses with heterologous antigens |
GB201814563D0 (en) * | 2018-09-07 | 2018-10-24 | Univ Leuven Kath | Chimeric flavivirus lyssavirus vaccines |
CN109943590B (zh) * | 2019-04-18 | 2022-11-18 | 西南大学 | 一种复制缺陷型猪圆环病毒、其制备方法及应用 |
CN110157685B (zh) * | 2019-05-20 | 2022-11-01 | 中国科学院武汉病毒研究所 | 一种复制缺陷西尼罗病毒的制备方法及应用 |
JP7221995B2 (ja) * | 2019-05-28 | 2023-02-14 | チェンマイ・ユニバーシティ | フラビウイルスの成熟ウイルス様粒子 |
WO2021048003A1 (en) * | 2019-09-13 | 2021-03-18 | Katholieke Universiteit Leuven | Chimeric filovirus vaccines |
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-
2009
- 2009-03-16 CN CN201510214045.3A patent/CN105039266A/zh active Pending
- 2009-03-16 JP JP2010550707A patent/JP5779352B2/ja not_active Expired - Fee Related
- 2009-03-16 EA EA201591888A patent/EA201591888A1/ru unknown
- 2009-03-16 BR BRPI0908936A patent/BRPI0908936A2/pt not_active IP Right Cessation
- 2009-03-16 WO PCT/US2009/001666 patent/WO2009114207A2/en active Application Filing
- 2009-03-16 UA UAA201012164A patent/UA103316C2/uk unknown
- 2009-03-16 MX MX2010010034A patent/MX2010010034A/es active IP Right Grant
- 2009-03-16 EP EP09720269A patent/EP2265284A4/en not_active Withdrawn
- 2009-03-16 CN CN200980116782.2A patent/CN102202687B/zh not_active Expired - Fee Related
- 2009-03-16 KR KR1020107023044A patent/KR101719316B1/ko active IP Right Grant
- 2009-03-16 SG SG2013018320A patent/SG188891A1/en unknown
- 2009-03-16 US US12/922,513 patent/US8815564B2/en not_active Expired - Fee Related
- 2009-03-16 CA CA2717499A patent/CA2717499A1/en not_active Abandoned
- 2009-03-16 AU AU2009223727A patent/AU2009223727B2/en not_active Ceased
- 2009-03-16 EA EA201001491A patent/EA023888B1/ru not_active IP Right Cessation
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2010
- 2010-09-08 ZA ZA2010/06437A patent/ZA201006437B/en unknown
- 2010-09-14 IL IL208147A patent/IL208147A/en not_active IP Right Cessation
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2012
- 2012-03-15 HK HK12102646.0A patent/HK1162306A1/xx not_active IP Right Cessation
- 2012-10-02 US US13/633,436 patent/US9217158B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HK1162306A1 (en) | 2012-08-31 |
US20110135686A1 (en) | 2011-06-09 |
CA2717499A1 (en) | 2009-09-17 |
ZA201006437B (en) | 2016-03-30 |
EA201591888A1 (ru) | 2016-05-31 |
EP2265284A2 (en) | 2010-12-29 |
WO2009114207A3 (en) | 2010-01-07 |
WO2009114207A2 (en) | 2009-09-17 |
IL208147A (en) | 2016-02-29 |
CN102202687B (zh) | 2015-07-29 |
JP2011516040A (ja) | 2011-05-26 |
CN102202687A (zh) | 2011-09-28 |
BRPI0908936A2 (pt) | 2017-03-28 |
KR20110002845A (ko) | 2011-01-10 |
US8815564B2 (en) | 2014-08-26 |
AU2009223727B2 (en) | 2014-09-11 |
MX2010010034A (es) | 2010-12-06 |
EP2265284A4 (en) | 2012-04-25 |
KR101719316B1 (ko) | 2017-03-24 |
CN105039266A (zh) | 2015-11-11 |
EA023888B1 (ru) | 2016-07-29 |
IL208147A0 (en) | 2010-12-30 |
SG188891A1 (en) | 2013-04-30 |
US20130243812A1 (en) | 2013-09-19 |
AU2009223727A1 (en) | 2009-09-17 |
JP5779352B2 (ja) | 2015-09-16 |
EA201001491A1 (ru) | 2011-06-30 |
US9217158B2 (en) | 2015-12-22 |
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