UA101214C2 - Гидролазы, кодирующеие их нуклеиновые кислоты и способы их получения и применения - Google Patents

Гидролазы, кодирующеие их нуклеиновые кислоты и способы их получения и применения

Info

Publication number
UA101214C2
UA101214C2 UAA201103761A UAA201103761A UA101214C2 UA 101214 C2 UA101214 C2 UA 101214C2 UA A201103761 A UAA201103761 A UA A201103761A UA A201103761 A UAA201103761 A UA A201103761A UA 101214 C2 UA101214 C2 UA 101214C2
Authority
UA
Ukraine
Prior art keywords
production
hydrolases
methods
nucleic acids
fatty acids
Prior art date
Application number
UAA201103761A
Other languages
English (en)
Ukrainian (uk)
Inventor
Кристофер Л.Г. ДЕЙТОН
Нельсон Бартон
Аналиа Буено
Джослин Г. Куенка
Тим Хитчмен
Кети А. Клайн
Джонатан Лайон
Марк Л. Миллер
Марк А. Уолл
Original Assignee
Бандж Ойлз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бандж Ойлз, Инк. filed Critical Бандж Ойлз, Инк.
Publication of UA101214C2 publication Critical patent/UA101214C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • A23D7/04—Working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
    • A23D9/04—Working-up
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/003—Refining fats or fatty oils by enzymes or microorganisms, living or dead
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • C11C1/04—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis
    • C11C1/045—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis using enzymes or microorganisms, living or dead
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/08—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with fatty acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/12—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6418—Fatty acids by hydrolysis of fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431—Linoleic acids [18:2[n-6]]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6454—Glycerides by esterification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)

Abstract

Изобретение относится к гидролазам, в том числе к липазам, и кодирующих их полинуклеотидов, а также способов получения и применения этих полинуклеотидов и полипептидов, способов получения масел с низким содержанием насыщенных жирных кислот или с низким содержанием транс-изомеров жирных кислот, таких как животные жиры или растительные масла с низким содержанием насыщенных жирных кислот или низким содержанием транс-изомеров жирных кислот.
UAA201103761A 2008-08-29 2009-08-28 Гидролазы, кодирующеие их нуклеиновые кислоты и способы их получения и применения UA101214C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/202,204 US8153391B2 (en) 2008-08-29 2008-08-29 Hydrolases, nucleic acids encoding them and methods for making and using them
PCT/US2009/004904 WO2010024924A2 (en) 2008-08-29 2009-08-28 Hydrolases, nucleic acids encoding them and methods for making and using them

Publications (1)

Publication Number Publication Date
UA101214C2 true UA101214C2 (ru) 2013-03-11

Family

ID=41664688

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201103761A UA101214C2 (ru) 2008-08-29 2009-08-28 Гидролазы, кодирующеие их нуклеиновые кислоты и способы их получения и применения

Country Status (13)

Country Link
US (6) US8153391B2 (ru)
EP (1) EP2329032B1 (ru)
CN (1) CN102325891B (ru)
AR (2) AR073236A1 (ru)
BR (1) BRPI0917220B1 (ru)
CA (1) CA2735265C (ru)
ES (1) ES2484919T3 (ru)
MX (1) MX2011002226A (ru)
MY (1) MY162662A (ru)
PL (1) PL2329032T3 (ru)
RU (1) RU2525675C2 (ru)
UA (1) UA101214C2 (ru)
WO (1) WO2010024924A2 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
BR112014031377B1 (pt) 2012-06-14 2020-09-01 Bunge Global Innovation Llc Processo para a produção de óleos saturados baixos
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
CN106591386A (zh) * 2014-07-07 2017-04-26 嘉必优生物技术（武汉）股份有限公司 含有2‑棕榈酸甘油酯的组合物的制备方法
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
US20170049121A1 (en) 2015-08-20 2017-02-23 Bunge Oils, Inc. High stearic high oleic shortening compositions and methods of making and using the same
CN109929820B (zh) * 2017-12-19 2022-10-11 丰益(上海)生物技术研发中心有限公司 新型的甘油单-二酰酯脂肪酶
CN108034647B (zh) * 2018-01-31 2020-08-04 江南大学 一种饱和脂肪酸特异性脂肪酶突变体及其应用
JP7359539B2 (ja) * 2018-03-29 2023-10-11 日清オイリオグループ株式会社 油脂組成物、加熱調理用油脂組成物、加熱調理用油脂組成物の製造方法、並びに、油脂組成物における酸価上昇及び色調上昇の抑制方法
WO2019213754A1 (en) * 2018-05-07 2019-11-14 Gates Ian D Method of enzymatic biotransformation of petroleum hydrocarbon
CN112534050A (zh) * 2018-05-18 2021-03-19 帝斯曼知识产权资产管理有限公司 突变体脂肪酶及其用途
WO2020123614A1 (en) * 2018-12-13 2020-06-18 Cargill, Incorporated Modified triglyceride including omega-3 fatty acid residue
JP2023540734A (ja) 2020-09-07 2023-09-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 夾雑リパーゼ活性を検出する方法
AU2023232901A1 (en) 2022-03-09 2024-08-01 Boehringer Ingelheim International Gmbh Method for detecting contaminating carboxylesterase activity
WO2024033465A1 (en) * 2022-08-10 2024-02-15 Boehringer Ingelheim International Gmbh Artificial mirnas targeting multiple hydrolases

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949105A (en) 1974-03-25 1976-04-06 Lever Brothers Company Margarine fat
US4261868A (en) 1979-08-08 1981-04-14 Lever Brothers Company Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4404128A (en) 1981-05-29 1983-09-13 The Procter & Gamble Company Enzyme detergent composition
IE54838B1 (en) 1982-04-30 1990-02-28 Unilever Plc Improvements in and relating to interesterification of triglycerides of fatty acids
DK402583D0 (da) 1983-09-05 1983-09-05 Novo Industri As Fremgangsmade til fremstilling af et immobiliseret lipasepraeparat og anvendelse deraf
US4707364A (en) 1984-01-27 1987-11-17 Miles Laboratories, Inc. Composition for accelerating cheese aging
US5204015A (en) 1984-05-29 1993-04-20 Genencor International, Inc. Subtilisin mutants
US5087571A (en) 1984-06-22 1992-02-11 President And Fellows Of Harvard College Method for providing a cell culture from a transgenic non-human mammal
US5691181A (en) 1984-08-21 1997-11-25 Celltech Limited DNA encoding lipase from human gastric mucosal tissue
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP1186660A3 (fr) 1985-03-30 2002-03-20 KAUFFMAN, Stuart A. Procédé d'obtension d'ADN, ARN, peptides, polypeptides ou protéines, par une technique de recombination d'ADN
US4752483A (en) 1986-05-30 1988-06-21 Campbell Soup Company Method for producing a highly flavored cheese ingredient
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
CH671155A5 (ru) 1986-08-18 1989-08-15 Clinical Technologies Ass
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5573933A (en) 1987-04-14 1996-11-12 Luminis Pty, Ltd. Transgenic pigs
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US4944944A (en) 1987-11-19 1990-07-31 Oklahoma Medical Research Foundation Dietary compositions and methods using bile salt-activated lipase
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5000975A (en) 1988-12-29 1991-03-19 American Home Products Corporation Randomized palm oil fat composition for infant formulas
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5069810A (en) 1989-03-16 1991-12-03 Olin Corporation Cleaning composition comprising microbial lipase SD2 and sodium dodecylbenzene sulfonate
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5288619A (en) 1989-12-18 1994-02-22 Kraft General Foods, Inc. Enzymatic method for preparing transesterified oils
US5387742A (en) 1990-06-15 1995-02-07 Scios Nova Inc. Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
US5641664A (en) 1990-11-23 1997-06-24 Plant Genetic Systems, N.V. Process for transforming monocotyledonous plants
IE914504A1 (en) 1990-12-20 1992-07-01 Ixsys Optimization of binding proteins
US6110700A (en) 1991-03-11 2000-08-29 The General Hospital Corporation PRAD1 cyclin and its cDNA
DE4115938A1 (de) 1991-05-16 1992-11-19 Metallgesellschaft Ag Enzymatisches verfahren zur verminderung des gehaltes an phosphorhaltigen bestandteilen in pflanzlichen und tierischen oelen
US5922854A (en) 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
CA2075135A1 (en) 1991-08-02 1993-02-03 David E. Ellis Particle-mediated transformation of gymnosperms
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
JPH05236997A (ja) 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
US5902617A (en) 1992-05-19 1999-05-11 Pabst; Patrea L. Enzyme supplemented baby formula
US5445955A (en) 1992-05-25 1995-08-29 The Nisshin Oil Mills, Ltd. Immobilization of lipase on a polymer carrier containing epoxy and tertiary amino groups
CA2097000A1 (en) 1992-05-27 1993-11-28 Norio Moriya Alkaline lipase, method for producing the same, microorganism producing the same and detergent composition containing alkaline lipase
AU5676394A (en) 1992-11-20 1994-06-22 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JPH08511159A (ja) 1993-05-20 1996-11-26 ロダース・クロックラーン・ビー・ブイ 固定化リパーゼ
JP2859520B2 (ja) 1993-08-30 1999-02-17 ノボ ノルディスク アクティーゼルスカブ リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物
JPH08509871A (ja) 1993-09-30 1996-10-22 アグラシータス インコーポレイテッド 異種ペルオキシダーゼを生産するトランスジェニック綿植物
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6468742B2 (en) 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
AU692841B2 (en) 1994-03-09 1998-06-18 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
WO1995024494A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Humanized milk
DE69534464T2 (de) 1994-03-29 2006-09-28 Novozymes A/S Alkalische amylase aus bacellus
US5750870A (en) 1994-06-17 1998-05-12 Agritope, Inc. Plant genetic transformation methods and transgenic plants
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5959171A (en) 1994-08-17 1999-09-28 Pharming B.V. Method for the production of biologically active polypeptides in a mammal's
JPH10504964A (ja) 1994-09-01 1998-05-19 メルク エンド カンパニー インコーポレーテッド 家族性型ヒトアミロイド前駆タンパク質を発現するトランスジェニック動物
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US5880327A (en) 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
EP0713917A1 (fr) * 1994-11-28 1996-05-29 Societe Des Produits Nestle S.A. Procédé d'hydrolyse des triglycérides d'acides gras polyinsaturés
US6187992B1 (en) 1994-12-05 2001-02-13 Merck & Co., Inc. Transgenic mouse having a disrupted amyloid precursor protein gene
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5633440A (en) 1994-12-20 1997-05-27 Dna Plant Technology Corporation P119 promoters and their uses
US6093562A (en) 1996-02-05 2000-07-25 Novo Nordisk A/S Amylase variants
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6313081B1 (en) 1995-04-28 2001-11-06 Henkel Kommanditgesellschaft Auf Aktien (Kgaa) Detergents comprising cellulases
US5552317A (en) 1995-05-26 1996-09-03 Industrial Technology Research Institute Method for preparing optically active homophenylalanine and esters thereof using lipase from wheat germ or Candida lipolytica
EP0832183B1 (en) * 1995-05-31 2005-08-24 Cognis IP Management GmbH Improved fat splitting process
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6197070B1 (en) 1996-05-15 2001-03-06 The Procter & Gamble Company Detergent compositions comprising alpha combination of α-amylases for malodor stripping
US6322595B1 (en) 1996-07-30 2001-11-27 The Procter & Gamble Company Detergent composition comprising two cellulase components, with and without a cellulose-binding domain
US6326341B1 (en) 1996-09-11 2001-12-04 The Procter & Gamble Company Low foaming automatic dishwashing compositions
US5834259A (en) 1996-10-28 1998-11-10 Monsanto Company Process and composition for preparing D-aspartic acid
SK80799A3 (en) 1996-12-19 2000-03-13 Unilever Nv Immobilized enzyme and its use for the processing of triglyceride oils
US6069122A (en) 1997-06-16 2000-05-30 The Procter & Gamble Company Dishwashing detergent compositions containing organic diamines for improved grease cleaning, sudsing, low temperature stability and dissolution
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
CA2276064C (en) 1997-01-17 2013-12-17 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
DE19703364A1 (de) 1997-01-30 1998-08-06 Henkel Ecolab Gmbh & Co Ohg Pastenförmiges Wasch- und Reinigungsmittel
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
CN100367023C (zh) 1997-09-11 2008-02-06 生物风险公司 制备高密度阵列的方法
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
WO1999023211A1 (en) 1997-10-30 1999-05-14 Novo Nordisk A/S α-AMYLASE MUTANTS
EP1032644B1 (en) 1997-11-10 2003-03-19 The Procter & Gamble Company Process for preparing a detergent tablet
DE69828574T2 (de) 1997-11-14 2005-10-06 Sankyo Co., Ltd. Transgenes Tier als Modell für Allergie und seine Verwendung
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6156952A (en) 1998-04-09 2000-12-05 Constituent Institution Of The University Of Maryland System HIV transgenic animals and uses therefor
EP1082482A1 (en) 1998-05-01 2001-03-14 Novozymes A/S Enhancers such as n-hydroxyacetanilide
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
DE19824705A1 (de) 1998-06-03 1999-12-09 Henkel Kgaa Amylase und Protease enthaltende Wasch- und Reinigungsmittel
JP4335995B2 (ja) 1998-07-22 2009-09-30 昭 神谷 環境保全型粒状洗浄用組成物
GB2340755B (en) 1998-08-24 2002-09-25 Cannon Rubber Ltd Breast pump insert
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6399121B1 (en) 1999-03-16 2002-06-04 Novozymes A/S Process for producing cheese
US6511824B1 (en) 1999-03-17 2003-01-28 Exelixis, Inc. Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
US6309871B1 (en) 1999-03-31 2001-10-30 Novozymes A/S Polypeptides having alkaline α-amylase activity
US6221653B1 (en) 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
US6653151B2 (en) 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement
US6337187B1 (en) 1999-11-05 2002-01-08 Millennium Pharmaceuticals, Inc. 18891, a novel human lipase
US20010008765A1 (en) 1999-12-06 2001-07-19 Fuji Photo Film Co., Ltd. DNA chip and reactive solid carrier
US6531644B1 (en) 2000-01-14 2003-03-11 Exelixis, Inc. Methods for identifying anti-cancer drug targets
AU1166502A (en) 2000-10-12 2002-04-22 Exelixis Inc Human ect2 and methods of use
US6309872B1 (en) 2000-11-01 2001-10-30 Novozymes Biotech, Inc Polypeptides having glucoamylase activity and nucleic acids encoding same
MXPA04007886A (es) 2002-02-13 2004-10-15 Dow Global Technologies Inc Sobre-expresion de genes de extremozimo en pseudomonadas y bacterias estrechamente relacionadas.
FI115842B (fi) * 2002-03-27 2005-07-29 Valio Oy Menetelmä konjugoidun linolihapon valmistamiseksi
CA3007908A1 (en) * 2003-03-07 2005-04-14 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
JP5087741B2 (ja) 2003-11-19 2012-12-05 フェネックス インコーポレイテッド 改良タンパク質発現系
EP1805302B1 (en) * 2004-10-08 2012-08-15 Novozymes A/S Hydrolysis of ester bonds with lipase
DE102005012113A1 (de) * 2004-12-27 2006-07-27 BSH Bosch und Siemens Hausgeräte GmbH Geschirrspülmaschine mit einer Trocknungsvorrichtung
WO2006096834A2 (en) * 2005-03-08 2006-09-14 Diversa Corporation Hydrolases, nucleic acids encoding them and methods for improving paper strength
US8569015B2 (en) 2006-05-30 2013-10-29 Pfenex Inc. RPA optimization
UA97127C2 (ru) 2006-12-06 2012-01-10 Бандж Ойлз, Инк. Способ непрерывной ферментативной обработки композиции, содержащей липид, и система для его осуществления

Also Published As

Publication number Publication date
US8349578B2 (en) 2013-01-08
PL2329032T3 (pl) 2014-09-30
US8541191B2 (en) 2013-09-24
ES2484919T3 (es) 2014-08-12
BRPI0917220B1 (pt) 2018-11-21
RU2011111747A (ru) 2012-10-10
US8313918B2 (en) 2012-11-20
CN102325891B (zh) 2015-01-07
US20110287495A1 (en) 2011-11-24
WO2010024924A2 (en) 2010-03-04
US8153391B2 (en) 2012-04-10
US8420342B2 (en) 2013-04-16
US8227215B2 (en) 2012-07-24
CN102325891A (zh) 2012-01-18
MX2011002226A (es) 2011-04-05
RU2525675C2 (ru) 2014-08-20
CA2735265C (en) 2019-04-23
MY162662A (en) 2017-06-30
CA2735265A1 (en) 2010-03-04
EP2329032A2 (en) 2011-06-08
WO2010024924A3 (en) 2010-04-29
US20110287136A1 (en) 2011-11-24
AR073236A1 (es) 2010-10-20
US20110287496A1 (en) 2011-11-24
AR105958A2 (es) 2017-11-29
EP2329032B1 (en) 2014-04-30
US20100055234A1 (en) 2010-03-04
US20120276618A1 (en) 2012-11-01
BRPI0917220A2 (pt) 2015-08-11
US20110281312A1 (en) 2011-11-17

Similar Documents

Publication Publication Date Title
UA101214C2 (ru) Гидролазы, кодирующеие их нуклеиновые кислоты и способы их получения и применения
CL2011001462A1 (es) Yarrowia sp. transgenica util en la fermentacion de acidos grasos poliinsaturados que comprende un polipeptido con actividad malonil-coa sintetasa; y metodo para reducir la produccion de malonatos como subproducto de la fermetacion basado en el uso de dicha yarrowia.
EP4219516A3 (en) Chiral control
EA201171291A1 (ru) Кормовая добавка
AU2018256637A1 (en) Brassica rod1 gene sequences and uses thereof
MY195138A (en) Microorganisms and Methods for Production of Specific Length Fatty Alcohols and Related Compounds
MY165098A (en) Production of dha and other lc-pufas in plants
WO2009135074A3 (en) Microorganisms for the production of methacrylic acid
SG179048A1 (en) Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
BR112012015501A8 (pt) Processo de biodegradação e composição
MX2010009072A (es) Polipeptidos que tienen actividad de lipasa y polinucleotidos que codifican para los mismos.
UA107682C2 (uk) Жир із соняшника з високою температурою плавлення для кондитерських виробів
UA107468C2 (ru) Новая дельта-9-элонгаза для получения масел, обогащенных полиненасыщенными жирными кислотами
ES2623454T3 (es) Reducción del contenido de ácidos grasos saturados en semillas de plantas
UA102451C2 (ru) Способ получения триглицеридной композиции
EA020145B9 (ru) Гидролазы, кодирующие их нуклеиновые кислоты и способы их получения и применения
MY173788A (en) Production method for oil and fat
EA201590164A1 (ru) Растения brassica с модифицированным составом масла семян
WO2008079545A3 (en) Generation of plants with altered protein, fiber, or oil content
UA94613C2 (ru) Модифицированный фермент dmo и трансгенное растение, которое его продуцирует
WO2008061153A3 (en) Generation of plants with altered protein, fiber, or oil content
WO2007103767A8 (en) Role of microrna in plant salt tolerance
MX2009006464A (es) Generacion de plantas con contenido de aceite, proteina o fibra alterado.
MX2009006462A (es) Generacion de plantas con contenido de aceite, proteina o fibra alterado.
WO2008061156A3 (en) Generation of plants with altered protein, fiber, or oil content