UA100132C2 - Isoxazolo-pyridine derivatives - Google Patents
Isoxazolo-pyridine derivativesInfo
- Publication number
- UA100132C2 UA100132C2 UAA201008007A UAA201008007A UA100132C2 UA 100132 C2 UA100132 C2 UA 100132C2 UA A201008007 A UAA201008007 A UA A201008007A UA A201008007 A UAA201008007 A UA A201008007A UA 100132 C2 UA100132 C2 UA 100132C2
- Authority
- UA
- Ukraine
- Prior art keywords
- optionally substituted
- calkyl
- pyridine derivatives
- halo
- isoxazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Данное изобретение касается производных изоксазолопиридина формулы II,где X, R-Rпринимают значения, описанные в пункте 1.Соединения являются активными относительно сайта связывания ГАМК А α5 рецептора и пригодны для лечения когнитивных расстройств, таких как болезнь Альцгеймера.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122240 | 2007-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA100132C2 true UA100132C2 (en) | 2012-11-26 |
Family
ID=40329314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201008007A UA100132C2 (en) | 2007-12-04 | 2008-11-26 | Isoxazolo-pyridine derivatives |
Country Status (34)
Country | Link |
---|---|
US (6) | US20090143371A1 (ru) |
EP (2) | EP2767536B1 (ru) |
JP (1) | JP5301557B2 (ru) |
KR (2) | KR20120102117A (ru) |
CN (1) | CN101889010B (ru) |
AR (1) | AR069523A1 (ru) |
AU (1) | AU2008333326B2 (ru) |
BR (1) | BRPI0820112B8 (ru) |
CA (1) | CA2707648C (ru) |
CL (1) | CL2008003591A1 (ru) |
CO (1) | CO6351788A2 (ru) |
CR (1) | CR11454A (ru) |
CY (2) | CY1116119T1 (ru) |
DK (2) | DK2767536T3 (ru) |
EC (1) | ECSP10010230A (ru) |
ES (2) | ES2531023T3 (ru) |
HK (1) | HK1149756A1 (ru) |
HR (2) | HRP20150348T1 (ru) |
HU (1) | HUE025545T2 (ru) |
IL (1) | IL205759A (ru) |
MA (1) | MA31865B1 (ru) |
MX (1) | MX2010005717A (ru) |
MY (1) | MY156747A (ru) |
NZ (1) | NZ585308A (ru) |
PE (2) | PE20130242A1 (ru) |
PL (2) | PL2767536T3 (ru) |
PT (2) | PT2767536E (ru) |
RS (2) | RS54355B1 (ru) |
RU (1) | RU2484091C2 (ru) |
SI (2) | SI2227467T1 (ru) |
TW (1) | TWI363624B (ru) |
UA (1) | UA100132C2 (ru) |
WO (1) | WO2009071476A1 (ru) |
ZA (1) | ZA201003631B (ru) |
Families Citing this family (65)
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AU2008333326B2 (en) | 2007-12-04 | 2013-05-30 | F. Hoffmann-La Roche Ag | Isoxazolo-pyridine derivatives |
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US8389550B2 (en) * | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
US8222246B2 (en) * | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
US20100280019A1 (en) | 2009-04-30 | 2010-11-04 | Roland Jakob-Roetne | Isoxazoles |
EP2427455B1 (en) * | 2009-05-05 | 2020-01-15 | F.Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
US8415379B2 (en) * | 2009-05-05 | 2013-04-09 | Hoffmann-La Roche Inc. | Pyridines |
KR101354335B1 (ko) * | 2009-05-05 | 2014-02-19 | 에프. 호프만-라 로슈 아게 | 인지 장애의 치료에 사용되는 gaba a 수용체 역 작용제로서의 아이속사졸-티아졸 유도체 |
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CA2787785C (en) | 2010-01-28 | 2018-03-06 | President And Fellows Of Harvard College | Compositions and methods for enhancing proteasome activity |
US20130252972A1 (en) | 2010-07-19 | 2013-09-26 | Syngenta Crop Protection Llc | Isoxazole, isothiazole, furane and thiophene compounds as microbicides |
CN103003265A (zh) | 2010-07-19 | 2013-03-27 | 先正达参股股份有限公司 | 杀微生物剂 |
WO2012027289A1 (en) | 2010-08-23 | 2012-03-01 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
US8835425B2 (en) * | 2010-11-05 | 2014-09-16 | Hoffmann-La Roche Inc. | Use of selective GABA A α5 negative allosteric modulators for the treatment of central nervous system conditions |
EP2457569A1 (en) | 2010-11-05 | 2012-05-30 | F. Hoffmann-La Roche AG | Use of active pharmaceutical compounds for the treatment of central nervous system conditions |
JP6208122B2 (ja) | 2011-05-12 | 2017-10-04 | プロテオステイシス セラピューティクス,インコーポレイテッド | プロテオスタシス調節因子 |
US8604062B2 (en) * | 2011-10-20 | 2013-12-10 | Hoffman-La Roche Inc. | Process for the preparation of isoxazolyl-methoxy nicotinic acids |
US8785435B2 (en) * | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
DK3141542T3 (da) | 2011-12-28 | 2020-08-10 | Global Blood Therapeutics Inc | Substituerede benzaldehydforbindelser og fremgangsmåder til anvendelse deraf ved øgning af vævsiltning |
US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
AU2013283488A1 (en) | 2012-06-26 | 2015-01-15 | Saniona Aps | A phenyl triazole derivative and its use for modulating the GABAA receptor complex |
WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
EP2877463B1 (en) * | 2012-06-26 | 2018-11-07 | Saniona A/S | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
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EA201591426A1 (ru) | 2013-03-15 | 2016-02-29 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
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EP3102208B1 (en) | 2014-02-07 | 2021-01-13 | Global Blood Therapeutics, Inc. | Crystalline polymorph of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
JP2017071553A (ja) * | 2014-02-25 | 2017-04-13 | 味の素株式会社 | ヘテロ原子−メチレン−ヘテロ環構造を有する新規化合物 |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
CN106810542B (zh) * | 2015-11-30 | 2021-03-09 | 苏州开拓药业股份有限公司 | 一种硫代咪唑烷酮化合物的晶型、盐型及其制备方法 |
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TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
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EP4334301A1 (en) | 2021-05-05 | 2024-03-13 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
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CN115286636A (zh) * | 2022-10-08 | 2022-11-04 | 上海赛默罗生物科技有限公司 | 烟酰胺晶型及其制备方法和用途 |
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2008
- 2008-11-26 AU AU2008333326A patent/AU2008333326B2/en active Active
- 2008-11-26 RU RU2010123923/04A patent/RU2484091C2/ru active
- 2008-11-26 RS RS20150703A patent/RS54355B1/en unknown
- 2008-11-26 CN CN2008801193998A patent/CN101889010B/zh active Active
- 2008-11-26 KR KR1020127018310A patent/KR20120102117A/ko not_active Application Discontinuation
- 2008-11-26 MY MYPI2010002566A patent/MY156747A/en unknown
- 2008-11-26 CA CA2707648A patent/CA2707648C/en active Active
- 2008-11-26 MX MX2010005717A patent/MX2010005717A/es active IP Right Grant
- 2008-11-26 KR KR1020107012058A patent/KR101237576B1/ko active IP Right Grant
- 2008-11-26 JP JP2010536409A patent/JP5301557B2/ja active Active
- 2008-11-26 PL PL14168581T patent/PL2767536T3/pl unknown
- 2008-11-26 HU HUE14168581A patent/HUE025545T2/en unknown
- 2008-11-26 EP EP14168581.8A patent/EP2767536B1/en active Active
- 2008-11-26 WO PCT/EP2008/066225 patent/WO2009071476A1/en active Application Filing
- 2008-11-26 DK DK14168581.8T patent/DK2767536T3/en active
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