TWI898399B - 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物 - Google Patents

含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物

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Publication number
TWI898399B
TWI898399B TW113102160A TW113102160A TWI898399B TW I898399 B TWI898399 B TW I898399B TW 113102160 A TW113102160 A TW 113102160A TW 113102160 A TW113102160 A TW 113102160A TW I898399 B TWI898399 B TW I898399B
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TW
Taiwan
Prior art keywords
cationic
eye drops
eye
sodium
salt
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TW113102160A
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English (en)
Chinese (zh)
Other versions
TW202423451A (zh
Inventor
髙橋恭平
浅田博之
神村明日香
森島健司
桃川雄介
遠藤健一
Original Assignee
日商參天製藥股份有限公司
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Publication of TW202423451A publication Critical patent/TW202423451A/zh
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Publication of TWI898399B publication Critical patent/TWI898399B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
TW113102160A 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物 TWI898399B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018035578 2018-02-28
JP2018-035578 2018-02-28

Publications (2)

Publication Number Publication Date
TW202423451A TW202423451A (zh) 2024-06-16
TWI898399B true TWI898399B (zh) 2025-09-21

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
TW113102160A TWI898399B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW114131509A TW202600146A (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW108106730A TWI781296B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW111140996A TWI833406B (zh) 2018-02-28 2019-02-27 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物

Family Applications After (3)

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TW114131509A TW202600146A (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW108106730A TWI781296B (zh) 2018-02-28 2019-02-27 含有迪夸弗索(Diquafosol)及陽離子性聚合物之眼科用組合物
TW111140996A TWI833406B (zh) 2018-02-28 2019-02-27 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物

Country Status (14)

Country Link
US (1) US20210000844A1 (https=)
EP (1) EP3760207A4 (https=)
JP (5) JP6716800B2 (https=)
KR (3) KR102796051B1 (https=)
CN (2) CN117137866A (https=)
BR (1) BR112020017661A2 (https=)
CA (1) CA3091700A1 (https=)
EA (1) EA202092030A1 (https=)
MX (2) MX2020008925A (https=)
PH (1) PH12020551313B1 (https=)
SG (1) SG11202007977RA (https=)
TW (4) TWI898399B (https=)
UA (1) UA129517C2 (https=)
WO (1) WO2019168023A1 (https=)

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CN117137866A (zh) * 2018-02-28 2023-12-01 参天制药株式会社 含有地夸磷索及阳离子性聚合物的眼科用组合物
ES2994624T3 (en) * 2019-02-27 2025-01-27 Santen Pharmaceutical Co Ltd Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
JPWO2023054669A1 (https=) * 2021-09-30 2023-04-06
KR102794468B1 (ko) 2022-04-04 2025-04-14 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
KR20250038935A (ko) * 2023-09-13 2025-03-20 루다큐어 주식회사 8-옥소-2'-데옥시구아노신 또는 이의 약학적으로 허용가능한 염을 포함하는 수용액 형태의 점안제
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

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JP6966667B2 (ja) 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物

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US5358706A (en) * 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
CN1140988A (zh) * 1994-02-18 1997-01-22 希巴-盖古股份公司 液体眼科缓释投药系统
TW201306844A (zh) * 2010-12-28 2013-02-16 參天製藥股份有限公司 含有迪夸弗索點眼液及其製造方法、不溶性析出物產生之抑制方法

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KR20250053220A (ko) 2025-04-21
SG11202007977RA (en) 2020-09-29
CN111757742A (zh) 2020-10-09
BR112020017661A2 (pt) 2020-12-22
MX2022014791A (es) 2023-01-16
JP6716800B2 (ja) 2020-07-01
PH12020551313A1 (en) 2021-09-06
EA202092030A1 (ru) 2020-11-16
US20210000844A1 (en) 2021-01-07
TW202306572A (zh) 2023-02-16
JP2020138980A (ja) 2020-09-03
JP7796782B2 (ja) 2026-01-09
EP3760207A4 (en) 2023-10-04
JP2024045506A (ja) 2024-04-02
KR102472773B1 (ko) 2022-11-30
KR102796051B1 (ko) 2025-04-14
KR20220163519A (ko) 2022-12-09
UA129517C2 (uk) 2025-05-21
JP7472202B2 (ja) 2024-04-22
CN117137866A (zh) 2023-12-01
TWI833406B (zh) 2024-02-21
TWI781296B (zh) 2022-10-21
CN111757742B (zh) 2023-09-26
CA3091700A1 (en) 2019-09-06
MX2020008925A (es) 2020-10-01
PH12020551313B1 (en) 2024-02-28
JP2026034664A (ja) 2026-02-27
TW202000212A (zh) 2020-01-01
TW202600146A (zh) 2026-01-01
JPWO2019168023A1 (ja) 2020-05-28
TW202423451A (zh) 2024-06-16
EP3760207A1 (en) 2021-01-06
JP2022136152A (ja) 2022-09-15
WO2019168023A1 (ja) 2019-09-06
KR20200127002A (ko) 2020-11-09
JP7297718B2 (ja) 2023-06-26

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