KR102796051B1 - 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 - Google Patents

디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Download PDF

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KR102796051B1
KR102796051B1 KR1020227041383A KR20227041383A KR102796051B1 KR 102796051 B1 KR102796051 B1 KR 102796051B1 KR 1020227041383 A KR1020227041383 A KR 1020227041383A KR 20227041383 A KR20227041383 A KR 20227041383A KR 102796051 B1 KR102796051 B1 KR 102796051B1
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cationic
diquafosol
eye
ophthalmic composition
chitosan
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KR20220163519A (ko
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교헤이 다카하시
히로유키 아사다
아스카 가미무라
겐지 모리시마
유스케 모모카와
겐이치 엔도
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산텐 세이야꾸 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
KR1020227041383A 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 Active KR102796051B1 (ko)

Priority Applications (1)

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KR1020257011738A KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2018035578 2018-02-28
JPJP-P-2018-035578 2018-02-28
KR1020207027473A KR102472773B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
PCT/JP2019/007542 WO2019168023A1 (ja) 2018-02-28 2019-02-27 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物

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KR20220163519A KR20220163519A (ko) 2022-12-09
KR102796051B1 true KR102796051B1 (ko) 2025-04-14

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KR1020227041383A Active KR102796051B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
KR1020207027473A Active KR102472773B1 (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
KR1020257011738A Pending KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

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KR1020257011738A Pending KR20250053220A (ko) 2018-02-28 2019-02-27 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물

Country Status (14)

Country Link
US (1) US20210000844A1 (https=)
EP (1) EP3760207A4 (https=)
JP (5) JP6716800B2 (https=)
KR (3) KR102796051B1 (https=)
CN (2) CN117137866A (https=)
BR (1) BR112020017661A2 (https=)
CA (1) CA3091700A1 (https=)
EA (1) EA202092030A1 (https=)
MX (2) MX2020008925A (https=)
PH (1) PH12020551313B1 (https=)
SG (1) SG11202007977RA (https=)
TW (4) TWI898399B (https=)
UA (1) UA129517C2 (https=)
WO (1) WO2019168023A1 (https=)

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CN117137866A (zh) * 2018-02-28 2023-12-01 参天制药株式会社 含有地夸磷索及阳离子性聚合物的眼科用组合物
ES2994624T3 (en) * 2019-02-27 2025-01-27 Santen Pharmaceutical Co Ltd Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer
JP6966667B2 (ja) * 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物
KR102365008B1 (ko) * 2020-06-23 2022-02-23 주식회사태준제약 디쿠아포솔을 포함하는 점안 조성물
JP7230169B2 (ja) * 2020-12-25 2023-02-28 参天製薬株式会社 ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液
CN113712910A (zh) * 2021-08-05 2021-11-30 广州市桐晖药业有限公司 一种滴眼液及其制备方法
JPWO2023054669A1 (https=) * 2021-09-30 2023-04-06
KR102794468B1 (ko) 2022-04-04 2025-04-14 서울대학교산학협력단 감미 억제용 조성물 및 식품의 감미 억제 방법
KR20250038935A (ko) * 2023-09-13 2025-03-20 루다큐어 주식회사 8-옥소-2'-데옥시구아노신 또는 이의 약학적으로 허용가능한 염을 포함하는 수용액 형태의 점안제
KR20250160050A (ko) 2024-05-03 2025-11-11 삼천당제약주식회사 물리화학적 특성이 개선된 안구건조증 예방 또는 치료용 약학 조성물
CN119970633A (zh) * 2025-03-26 2025-05-13 苏州乐珠制药有限公司 一种地夸磷索钠滴眼液及其制备方法

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ES2994624T3 (en) * 2019-02-27 2025-01-27 Santen Pharmaceutical Co Ltd Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer
JP6966667B2 (ja) 2019-08-27 2021-11-17 参天製薬株式会社 ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物

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WO2016104704A1 (ja) * 2014-12-25 2016-06-30 参天製薬株式会社 水性点眼液

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KR20250053220A (ko) 2025-04-21
SG11202007977RA (en) 2020-09-29
CN111757742A (zh) 2020-10-09
BR112020017661A2 (pt) 2020-12-22
MX2022014791A (es) 2023-01-16
JP6716800B2 (ja) 2020-07-01
PH12020551313A1 (en) 2021-09-06
EA202092030A1 (ru) 2020-11-16
US20210000844A1 (en) 2021-01-07
TW202306572A (zh) 2023-02-16
JP2020138980A (ja) 2020-09-03
TWI898399B (zh) 2025-09-21
JP7796782B2 (ja) 2026-01-09
EP3760207A4 (en) 2023-10-04
JP2024045506A (ja) 2024-04-02
KR102472773B1 (ko) 2022-11-30
KR20220163519A (ko) 2022-12-09
UA129517C2 (uk) 2025-05-21
JP7472202B2 (ja) 2024-04-22
CN117137866A (zh) 2023-12-01
TWI833406B (zh) 2024-02-21
TWI781296B (zh) 2022-10-21
CN111757742B (zh) 2023-09-26
CA3091700A1 (en) 2019-09-06
MX2020008925A (es) 2020-10-01
PH12020551313B1 (en) 2024-02-28
JP2026034664A (ja) 2026-02-27
TW202000212A (zh) 2020-01-01
TW202600146A (zh) 2026-01-01
JPWO2019168023A1 (ja) 2020-05-28
TW202423451A (zh) 2024-06-16
EP3760207A1 (en) 2021-01-06
JP2022136152A (ja) 2022-09-15
WO2019168023A1 (ja) 2019-09-06
KR20200127002A (ko) 2020-11-09
JP7297718B2 (ja) 2023-06-26

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