TWI750139B - 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 - Google Patents

用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 Download PDF

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TWI750139B
TWI750139B TW105134405A TW105134405A TWI750139B TW I750139 B TWI750139 B TW I750139B TW 105134405 A TW105134405 A TW 105134405A TW 105134405 A TW105134405 A TW 105134405A TW I750139 B TWI750139 B TW I750139B
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seq
amino acid
acid sequence
sequence
cdr
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TW105134405A
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TW201730210A (zh
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志勇 楊
蓋瑞 那貝爾
玲 徐
蓉 魏
華偉 邱
約亨 貝寧格
約亨 古柏
艾寇爾 拉歐
沃爾夫 藍區諾
克里斯汀 比爾
克里斯汀 藍格
馬克 康納斯
約翰 馬斯可拉
理查 古柏
金海 黃
尼可 多莉亞羅斯
東清 周
彼得 鄺
榮多 權
阿瑪連得 佩古
曼加卡拉希 阿索肯
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法商賽諾菲公司
美國衛生及公共服務部
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TW105134405A 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白 TWI750139B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562246113P 2015-10-25 2015-10-25
US62/246,113 2015-10-25
EP16305211 2016-02-24
EP16305211.1 2016-02-24
US201662322029P 2016-04-13 2016-04-13
US62/322,029 2016-04-13
US201662331169P 2016-05-03 2016-05-03
US62/331,169 2016-05-03

Publications (2)

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TW201730210A TW201730210A (zh) 2017-09-01
TWI750139B true TWI750139B (zh) 2021-12-21

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TW105134405A TWI750139B (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及/或三價結合蛋白
TW110126977A TW202219064A (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及／或三價結合蛋白
TW113100534A TW202442675A (zh) 2015-10-25 2016-10-25 用於預防或治療hiv感染之三特異性及/或三價結合蛋白

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TW110126977A TW202219064A (zh) 2015-10-25 2016-10-25 用於預防或治療ｈｉｖ感染之三特異性及／或三價結合蛋白
TW113100534A TW202442675A (zh) 2015-10-25 2016-10-25 用於預防或治療hiv感染之三特異性及/或三價結合蛋白

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US (4) US20190054182A1 (https=)
EP (2) EP3819310A1 (https=)
JP (3) JP7169190B2 (https=)
KR (1) KR102687212B1 (https=)
CN (4) CN116789841A (https=)
AR (1) AR106466A1 (https=)
AU (2) AU2016347058B2 (https=)
BR (1) BR112018008011A2 (https=)
CA (1) CA3002664A1 (https=)
CL (1) CL2018001065A1 (https=)
CO (1) CO2018005337A2 (https=)
CR (1) CR20180288A (https=)
DO (1) DOP2018000102A (https=)
EA (1) EA201891028A1 (https=)
ES (1) ES2894304T3 (https=)
HR (1) HRP20211528T1 (https=)
HU (1) HUE056608T2 (https=)
IL (2) IL301140A (https=)
MA (1) MA42641A1 (https=)
MX (2) MX2018005048A (https=)
MY (1) MY192278A (https=)
PE (1) PE20181167A1 (https=)
PH (1) PH12018500873A1 (https=)
PL (1) PL3365366T3 (https=)
RS (1) RS62437B1 (https=)
SG (1) SG11201803324VA (https=)
SI (1) SI3365366T1 (https=)
TW (3) TWI750139B (https=)
UY (1) UY36965A (https=)
WO (1) WO2017074878A1 (https=)

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