TWI746580B - 纖溶酶原在製備預防和治療脂肪代謝紊亂及其相關病症的藥物中的用途 - Google Patents

纖溶酶原在製備預防和治療脂肪代謝紊亂及其相關病症的藥物中的用途 Download PDF

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TWI746580B
TWI746580B TW106120492A TW106120492A TWI746580B TW I746580 B TWI746580 B TW I746580B TW 106120492 A TW106120492 A TW 106120492A TW 106120492 A TW106120492 A TW 106120492A TW I746580 B TWI746580 B TW I746580B
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plasminogen
mice
fat
atherosclerosis
disease
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TW201822806A (zh
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李季男
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大陸商深圳瑞健生命科學硏究院有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Wood Science & Technology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW106120492A 2016-12-15 2017-06-19 纖溶酶原在製備預防和治療脂肪代謝紊亂及其相關病症的藥物中的用途 TWI746580B (zh)

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??PCT/CN2016/110168 2016-12-15
??PCT/CN2016/110172 2016-12-15
WOPCT/CN2016/110168 2016-12-15
CN2016110168 2016-12-15
CN2016110172 2016-12-15
WOPCT/CN2016/110172 2016-12-15

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TW201822806A TW201822806A (zh) 2018-07-01
TWI746580B true TWI746580B (zh) 2021-11-21

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TW106120492A TWI746580B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備預防和治療脂肪代謝紊亂及其相關病症的藥物中的用途
TW106120464A TWI684459B (zh) 2016-12-15 2017-06-19 一種治療動脈粥樣硬化及其併發症的方法
TW106120463A TWI680764B (zh) 2016-12-15 2017-06-19 一種預防動脈粥樣硬化及其併發症的方法
TW106120501A TW201822812A (zh) 2016-12-15 2017-06-19 一種預防和治療肥胖症的方法
TW106120491A TW201822805A (zh) 2016-12-15 2017-06-19 一種預防和治療脂肪異常沉積導致的組織損傷的方法
TW106120499A TW201822810A (zh) 2016-12-15 2017-06-19 一種預防和治療脂肪肝的方法
TW110105040A TW202123963A (zh) 2016-12-15 2017-06-19 一種治療冠狀動脈粥樣硬化及其併發症的方法
TW106120498A TW201822809A (zh) 2016-12-15 2017-06-19 一種預防和治療高脂血症的方法
TW106120465A TWI750189B (zh) 2016-12-15 2017-06-19 一種治療冠狀動脈粥樣硬化及其併發症的方法

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TW106120464A TWI684459B (zh) 2016-12-15 2017-06-19 一種治療動脈粥樣硬化及其併發症的方法
TW106120463A TWI680764B (zh) 2016-12-15 2017-06-19 一種預防動脈粥樣硬化及其併發症的方法
TW106120501A TW201822812A (zh) 2016-12-15 2017-06-19 一種預防和治療肥胖症的方法
TW106120491A TW201822805A (zh) 2016-12-15 2017-06-19 一種預防和治療脂肪異常沉積導致的組織損傷的方法
TW106120499A TW201822810A (zh) 2016-12-15 2017-06-19 一種預防和治療脂肪肝的方法
TW110105040A TW202123963A (zh) 2016-12-15 2017-06-19 一種治療冠狀動脈粥樣硬化及其併發症的方法
TW106120498A TW201822809A (zh) 2016-12-15 2017-06-19 一種預防和治療高脂血症的方法
TW106120465A TWI750189B (zh) 2016-12-15 2017-06-19 一種治療冠狀動脈粥樣硬化及其併發症的方法

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US (4) US11478535B2 (enExample)
EP (4) EP3556391A4 (enExample)
JP (4) JP7160351B2 (enExample)
CN (4) CN110366425A (enExample)
CA (4) CA3047168A1 (enExample)
TW (9) TWI746580B (enExample)
WO (8) WO2018107685A1 (enExample)

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CN110114080A (zh) 2016-12-15 2019-08-09 泰伦基国际有限公司 一种预防和治疗皮肤纤维化的方法
CN110366425A (zh) * 2016-12-15 2019-10-22 泰伦基国际有限公司 一种预防动脉粥样硬化及其并发症的方法
JP7171572B2 (ja) 2016-12-15 2022-11-15 タレンゲン インターナショナル リミテッド 糖尿病を治療するための新しい方法
WO2018108161A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗肥胖症的方法和药物
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TWI714862B (zh) * 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
CN115551534A (zh) * 2020-02-26 2022-12-30 泰伦基国际有限公司 一种预防和治疗血压异常病症的方法和药物
KR20220156935A (ko) * 2020-03-24 2022-11-28 탈렌젠 인터내셔널 리미티드 헌팅톤병의 치료 방법 및 약물
EP4140498A4 (en) * 2020-05-11 2023-11-01 Talengen International Limited METHOD AND DRUGS FOR TREATING SPINAL MUSCLE ATROPHY
CN112056563A (zh) * 2020-09-15 2020-12-11 王胜林 用于修复脂质代谢障碍的营养素组合物及其应用
CN113041247A (zh) * 2021-04-21 2021-06-29 中山大学孙逸仙纪念医院 伊玛替尼在防治新型冠状病毒及并发症药物中的应用

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