TWI727926B - 用於治療發炎及過敏病狀之脂肪酸及軟脂醯乙醇醯胺之混合物及其用途 - Google Patents

用於治療發炎及過敏病狀之脂肪酸及軟脂醯乙醇醯胺之混合物及其用途 Download PDF

Info

Publication number
TWI727926B
TWI727926B TW104125530A TW104125530A TWI727926B TW I727926 B TWI727926 B TW I727926B TW 104125530 A TW104125530 A TW 104125530A TW 104125530 A TW104125530 A TW 104125530A TW I727926 B TWI727926 B TW I727926B
Authority
TW
Taiwan
Prior art keywords
mixture
acid
composition
present
weight
Prior art date
Application number
TW104125530A
Other languages
English (en)
Chinese (zh)
Other versions
TW201609084A (zh
Inventor
拉菲爾 米里亞齊歐
安東內拉 沙代
卡蜜拉 米里亞齊歐
Original Assignee
義大利商阿里研究簡易股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 義大利商阿里研究簡易股份有限公司 filed Critical 義大利商阿里研究簡易股份有限公司
Publication of TW201609084A publication Critical patent/TW201609084A/zh
Application granted granted Critical
Publication of TWI727926B publication Critical patent/TWI727926B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW104125530A 2014-08-08 2015-08-06 用於治療發炎及過敏病狀之脂肪酸及軟脂醯乙醇醯胺之混合物及其用途 TWI727926B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2014A001474 2014-08-08
ITMI20141474 2014-08-08

Publications (2)

Publication Number Publication Date
TW201609084A TW201609084A (zh) 2016-03-16
TWI727926B true TWI727926B (zh) 2021-05-21

Family

ID=51663273

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104125530A TWI727926B (zh) 2014-08-08 2015-08-06 用於治療發炎及過敏病狀之脂肪酸及軟脂醯乙醇醯胺之混合物及其用途

Country Status (13)

Country Link
US (2) US9962355B2 (enExample)
EP (1) EP3177281B1 (enExample)
JP (3) JP7118642B2 (enExample)
CN (1) CN106714792A (enExample)
CA (1) CA2957700C (enExample)
CO (1) CO2017001088A2 (enExample)
DK (1) DK3177281T3 (enExample)
ES (1) ES2976095T3 (enExample)
FI (1) FI3177281T3 (enExample)
IL (1) IL250271B2 (enExample)
MA (1) MA40417A (enExample)
TW (1) TWI727926B (enExample)
WO (1) WO2016020828A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016334086B2 (en) * 2015-10-07 2022-10-20 Cormedix Inc. Skin-penetrating formulation of taurolidine
CN109893520A (zh) * 2019-03-21 2019-06-18 中国科学院水生生物研究所 螺旋藻γ-亚麻酸的新用途
AU2020260090C9 (en) * 2019-04-15 2023-08-31 Metagenics LLC Novel hemp and PEA formulation and its use
JP2023542340A (ja) * 2020-09-21 2023-10-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 代謝物の免疫学的作用
IT202100024464A1 (it) * 2021-09-23 2023-03-23 Epitech Group S P A N-palmitoil-etanolamide e acido docosaesaenoico per l’uso nel trattamento del disturbo dello spettro autistico e di altre sindromi depressive
CN114209683A (zh) * 2021-12-22 2022-03-22 中南大学湘雅三医院 壬二酸在制备治疗炎症性肠病药物中的应用
KR20240164914A (ko) * 2022-03-14 2024-11-21 페라 다이아그노스틱스 앤드 바이올로지컬스 코프. 지방산 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679667A (en) * 1992-04-24 1997-10-21 Lifegroup S.P.A. Aminoalcohols-N-Acyl derivatives as therapeutical agents against the neurogenic endoneural edema of the peripheral nerve
WO2008075978A2 (en) * 2006-12-20 2008-06-26 Seperex Nutritionals Limited An extract

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1252865B (it) * 1991-12-31 1995-06-28 Lifegroup Spa N-acilderivati di aminoalcooli attivi come autocoidi locali ed utilizzabili nella terapia dei processi autoimmuni
IT1257697B (it) * 1992-04-24 1996-02-01 Lifegroup Spa N-acil derivati di aminoalcooli come agenti terapeutici attivi sull'edema neurogenico endoneurale a livello del nervo periferico.
KR0179393B1 (ko) 1992-06-19 1999-03-20 린다 에스. 스티븐슨 표피 보습화 및 장벽 기능 치유용 지질
EP0620000A3 (de) * 1992-12-18 1994-11-02 Rhone-Poulenc Rorer Gmbh Kosmetische und/oder pharmazeutische Verwendung von N-Acylalkanolaminen
US5599548A (en) * 1995-05-08 1997-02-04 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides and retinol or retinyl ester
US5716627A (en) * 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
JP2000159668A (ja) * 1998-11-26 2000-06-13 Nof Corp サイトカイン抑制剤
JP2000191525A (ja) * 1998-12-25 2000-07-11 Nof Corp 皮膚外用剤組成物
GB9923738D0 (en) * 1999-10-07 1999-12-08 Nestle Sa Nutritional composition
US20020143059A1 (en) * 2000-12-28 2002-10-03 Sreekumar Pillai Skin care product containing retinoids, retinoid booster and phytoestrogens in a dual compartment package
DE10217131A1 (de) * 2001-07-31 2003-02-13 Kuhs Kosmetik Gmbh & Co Kg Topisch applizierbare Zusammensetzung sowie Werkstoffgemisch
ES2344920T3 (es) * 2006-03-28 2010-09-09 Epitech Group S.R.L. Composicion farmaceutica para el tratamiento de patologias provocadas por la respuesta general del sistema inmutario.
ES2610880T3 (es) 2008-02-22 2017-05-03 Rigel Pharmaceuticals, Inc. Uso de 2,4-pirimidinadiaminas para el tratamiento de la aterosclerosis
DE202008007621U1 (de) 2008-06-04 2008-11-06 Zimmer, Bruno Kosmetisches und Nahrungsmittel aus unterschiedlichen Fettsäuren
AU2011223730A1 (en) * 2010-03-02 2012-10-18 Imagenetix, Inc. Compositions comprising myristic acid and uses thereof
US8618095B2 (en) 2010-04-13 2013-12-31 Rigel Pharmaceuticals, Inc. 2, 4-pyrimidinediamine compounds and prodrugs thereof and their uses
ITMI20111284A1 (it) 2011-07-11 2013-01-12 Giovanni Nusca Composizione farmaceutica.
WO2013171316A1 (en) 2012-05-18 2013-11-21 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
ITMI20130354A1 (it) * 2013-03-08 2014-09-09 Again Life Italia Srl Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie.
CN103242262A (zh) * 2013-05-24 2013-08-14 厦门大学 N-脂肪酰基乙醇胺水解酶抑制剂及其合成方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679667A (en) * 1992-04-24 1997-10-21 Lifegroup S.P.A. Aminoalcohols-N-Acyl derivatives as therapeutical agents against the neurogenic endoneural edema of the peripheral nerve
WO2008075978A2 (en) * 2006-12-20 2008-06-26 Seperex Nutritionals Limited An extract

Also Published As

Publication number Publication date
WO2016020828A1 (en) 2016-02-11
JP2023041806A (ja) 2023-03-24
IL250271B (en) 2022-10-01
JP2017523230A (ja) 2017-08-17
CN106714792A (zh) 2017-05-24
US10149827B2 (en) 2018-12-11
ES2976095T3 (es) 2024-07-23
JP7335475B2 (ja) 2023-08-30
EP3177281A1 (en) 2017-06-14
EP3177281B1 (en) 2023-12-06
TW201609084A (zh) 2016-03-16
MA40417A (fr) 2017-06-14
US20170224645A1 (en) 2017-08-10
CO2017001088A2 (es) 2017-04-28
CA2957700C (en) 2022-12-13
FI3177281T3 (fi) 2024-03-13
IL250271A0 (en) 2017-03-30
US9962355B2 (en) 2018-05-08
DK3177281T3 (da) 2024-03-11
US20180243254A1 (en) 2018-08-30
JP2021004260A (ja) 2021-01-14
CA2957700A1 (en) 2016-02-11
BR112017002474A2 (pt) 2017-12-05
IL250271B2 (en) 2023-02-01
JP7118642B2 (ja) 2022-08-16

Similar Documents

Publication Publication Date Title
TWI727926B (zh) 用於治療發炎及過敏病狀之脂肪酸及軟脂醯乙醇醯胺之混合物及其用途
RU2276975C2 (ru) Терапевтические комбинации жирных кислот
US20210290578A1 (en) Mixture of fatty acids for use in the treatment of inflammatory pathologies
JPH0232017A (ja) 精神分裂症および／または関連した晩発性運動障害の治療のための薬剤を製造する方法
RS51195B (sr) Upotreba visoko koncentrovanih kompozicija odabranih n-3-masnih kiselina za lečenje poremećaja centralnog nervnog sistema
JP2017523230A5 (enExample)
CA2986371C (en) Combination comprising palmitoylethanolamide (pea) and lycopene for use in the treatment of inflammatory diseases
WO2013030669A2 (en) Treatment of inflammatory disease or disorder and compositions therefor
BR112017002474B1 (pt) Mistura contendo ácido graxo e palmitoiletanolamida e composição compreendendo tal mistura
WO2025075519A1 (en) Preparation and its application in atopic dermatitis in children
ITMI20142077A1 (it) Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie
RU99106551A (ru) Применение арахидоновой кислоты и/или докозагексаеновой кислоты для получения лекарства для лечения диспраксии