IL250271B2 - A mixture of fatty acids and palmitoylethanolamide for use in the treatment of inflammatory and allergic pathologies - Google Patents
A mixture of fatty acids and palmitoylethanolamide for use in the treatment of inflammatory and allergic pathologiesInfo
- Publication number
- IL250271B2 IL250271B2 IL250271A IL25027117A IL250271B2 IL 250271 B2 IL250271 B2 IL 250271B2 IL 250271 A IL250271 A IL 250271A IL 25027117 A IL25027117 A IL 25027117A IL 250271 B2 IL250271 B2 IL 250271B2
- Authority
- IL
- Israel
- Prior art keywords
- mixture
- acid
- composition according
- weight
- palmitoylethanolamide
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 36
- 235000014113 dietary fatty acids Nutrition 0.000 title claims 9
- 229930195729 fatty acid Natural products 0.000 title claims 9
- 239000000194 fatty acid Substances 0.000 title claims 9
- 150000004665 fatty acids Chemical class 0.000 title claims 9
- 229950007031 palmidrol Drugs 0.000 title claims 7
- HXYVTAGFYLMHSO-UHFFFAOYSA-N palmitoyl ethanolamide Chemical compound CCCCCCCCCCCCCCCC(=O)NCCO HXYVTAGFYLMHSO-UHFFFAOYSA-N 0.000 title claims 7
- 230000007170 pathology Effects 0.000 title claims 3
- 230000000172 allergic effect Effects 0.000 title claims 2
- 208000010668 atopic eczema Diseases 0.000 title claims 2
- 230000002757 inflammatory effect Effects 0.000 title claims 2
- 239000006071 cream Substances 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 4
- 239000002674 ointment Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 241000792859 Enema Species 0.000 claims 1
- 235000021360 Myristic acid Nutrition 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
- 229940059082 douche Drugs 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000007920 enema Substances 0.000 claims 1
- 229940095399 enema Drugs 0.000 claims 1
- -1 eyewash Substances 0.000 claims 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 1
- 229960002733 gamolenic acid Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 230000002314 neuroinflammatory effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 229960002969 oleic acid Drugs 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229940098695 palmitic acid Drugs 0.000 claims 1
- 239000011049 pearl Substances 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 229960004274 stearic acid Drugs 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20141474 | 2014-08-08 | ||
| PCT/IB2015/055885 WO2016020828A1 (en) | 2014-08-08 | 2015-08-03 | Mixture of fatty acids and palmitoylethanolamide for use in the treatment of inflammatory and allergic pathologies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL250271A0 IL250271A0 (en) | 2017-03-30 |
| IL250271B IL250271B (en) | 2022-10-01 |
| IL250271B2 true IL250271B2 (en) | 2023-02-01 |
Family
ID=51663273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL250271A IL250271B2 (en) | 2014-08-08 | 2017-01-25 | A mixture of fatty acids and palmitoylethanolamide for use in the treatment of inflammatory and allergic pathologies |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9962355B2 (enExample) |
| EP (1) | EP3177281B1 (enExample) |
| JP (3) | JP7118642B2 (enExample) |
| CN (1) | CN106714792A (enExample) |
| CA (1) | CA2957700C (enExample) |
| CO (1) | CO2017001088A2 (enExample) |
| DK (1) | DK3177281T3 (enExample) |
| ES (1) | ES2976095T3 (enExample) |
| FI (1) | FI3177281T3 (enExample) |
| IL (1) | IL250271B2 (enExample) |
| MA (1) | MA40417A (enExample) |
| TW (1) | TWI727926B (enExample) |
| WO (1) | WO2016020828A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016334086B2 (en) * | 2015-10-07 | 2022-10-20 | Cormedix Inc. | Skin-penetrating formulation of taurolidine |
| CN109893520A (zh) * | 2019-03-21 | 2019-06-18 | 中国科学院水生生物研究所 | 螺旋藻γ-亚麻酸的新用途 |
| AU2020260090C9 (en) * | 2019-04-15 | 2023-08-31 | Metagenics LLC | Novel hemp and PEA formulation and its use |
| JP2023542340A (ja) * | 2020-09-21 | 2023-10-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 代謝物の免疫学的作用 |
| IT202100024464A1 (it) * | 2021-09-23 | 2023-03-23 | Epitech Group S P A | N-palmitoil-etanolamide e acido docosaesaenoico per l’uso nel trattamento del disturbo dello spettro autistico e di altre sindromi depressive |
| CN114209683A (zh) * | 2021-12-22 | 2022-03-22 | 中南大学湘雅三医院 | 壬二酸在制备治疗炎症性肠病药物中的应用 |
| KR20240164914A (ko) * | 2022-03-14 | 2024-11-21 | 페라 다이아그노스틱스 앤드 바이올로지컬스 코프. | 지방산 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679667A (en) * | 1992-04-24 | 1997-10-21 | Lifegroup S.P.A. | Aminoalcohols-N-Acyl derivatives as therapeutical agents against the neurogenic endoneural edema of the peripheral nerve |
| EP1844784A1 (en) * | 2006-03-28 | 2007-10-17 | Epitech Group S.r.l. | A pharmaceutical composition for the treatment of pathologies caused by the general response of the immune system |
| WO2008075978A2 (en) * | 2006-12-20 | 2008-06-26 | Seperex Nutritionals Limited | An extract |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1252865B (it) * | 1991-12-31 | 1995-06-28 | Lifegroup Spa | N-acilderivati di aminoalcooli attivi come autocoidi locali ed utilizzabili nella terapia dei processi autoimmuni |
| IT1257697B (it) * | 1992-04-24 | 1996-02-01 | Lifegroup Spa | N-acil derivati di aminoalcooli come agenti terapeutici attivi sull'edema neurogenico endoneurale a livello del nervo periferico. |
| KR0179393B1 (ko) | 1992-06-19 | 1999-03-20 | 린다 에스. 스티븐슨 | 표피 보습화 및 장벽 기능 치유용 지질 |
| EP0620000A3 (de) * | 1992-12-18 | 1994-11-02 | Rhone-Poulenc Rorer Gmbh | Kosmetische und/oder pharmazeutische Verwendung von N-Acylalkanolaminen |
| US5599548A (en) * | 1995-05-08 | 1997-02-04 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides and retinol or retinyl ester |
| US5716627A (en) * | 1996-04-25 | 1998-02-10 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester |
| JP2000159668A (ja) * | 1998-11-26 | 2000-06-13 | Nof Corp | サイトカイン抑制剤 |
| JP2000191525A (ja) * | 1998-12-25 | 2000-07-11 | Nof Corp | 皮膚外用剤組成物 |
| GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US20020143059A1 (en) * | 2000-12-28 | 2002-10-03 | Sreekumar Pillai | Skin care product containing retinoids, retinoid booster and phytoestrogens in a dual compartment package |
| DE10217131A1 (de) * | 2001-07-31 | 2003-02-13 | Kuhs Kosmetik Gmbh & Co Kg | Topisch applizierbare Zusammensetzung sowie Werkstoffgemisch |
| ES2610880T3 (es) | 2008-02-22 | 2017-05-03 | Rigel Pharmaceuticals, Inc. | Uso de 2,4-pirimidinadiaminas para el tratamiento de la aterosclerosis |
| DE202008007621U1 (de) | 2008-06-04 | 2008-11-06 | Zimmer, Bruno | Kosmetisches und Nahrungsmittel aus unterschiedlichen Fettsäuren |
| AU2011223730A1 (en) * | 2010-03-02 | 2012-10-18 | Imagenetix, Inc. | Compositions comprising myristic acid and uses thereof |
| US8618095B2 (en) | 2010-04-13 | 2013-12-31 | Rigel Pharmaceuticals, Inc. | 2, 4-pyrimidinediamine compounds and prodrugs thereof and their uses |
| ITMI20111284A1 (it) | 2011-07-11 | 2013-01-12 | Giovanni Nusca | Composizione farmaceutica. |
| WO2013171316A1 (en) | 2012-05-18 | 2013-11-21 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
| ITMI20130354A1 (it) * | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
| CN103242262A (zh) * | 2013-05-24 | 2013-08-14 | 厦门大学 | N-脂肪酰基乙醇胺水解酶抑制剂及其合成方法和用途 |
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2015
- 2015-08-03 EP EP15754028.7A patent/EP3177281B1/en active Active
- 2015-08-03 CN CN201580042308.5A patent/CN106714792A/zh active Pending
- 2015-08-03 FI FIEP15754028.7T patent/FI3177281T3/fi active
- 2015-08-03 ES ES15754028T patent/ES2976095T3/es active Active
- 2015-08-03 US US15/502,316 patent/US9962355B2/en active Active
- 2015-08-03 CA CA2957700A patent/CA2957700C/en active Active
- 2015-08-03 WO PCT/IB2015/055885 patent/WO2016020828A1/en not_active Ceased
- 2015-08-03 JP JP2017508099A patent/JP7118642B2/ja active Active
- 2015-08-03 MA MA040417A patent/MA40417A/fr unknown
- 2015-08-03 DK DK15754028.7T patent/DK3177281T3/da active
- 2015-08-06 TW TW104125530A patent/TWI727926B/zh active
-
2017
- 2017-01-25 IL IL250271A patent/IL250271B2/en unknown
- 2017-02-06 CO CONC2017/0001088A patent/CO2017001088A2/es unknown
-
2018
- 2018-04-06 US US15/946,950 patent/US10149827B2/en active Active
-
2020
- 2020-10-13 JP JP2020172613A patent/JP7335475B2/ja active Active
-
2023
- 2023-01-31 JP JP2023012916A patent/JP2023041806A/ja not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Also Published As
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| WO2016020828A1 (en) | 2016-02-11 |
| JP2023041806A (ja) | 2023-03-24 |
| IL250271B (en) | 2022-10-01 |
| JP2017523230A (ja) | 2017-08-17 |
| CN106714792A (zh) | 2017-05-24 |
| US10149827B2 (en) | 2018-12-11 |
| ES2976095T3 (es) | 2024-07-23 |
| JP7335475B2 (ja) | 2023-08-30 |
| EP3177281A1 (en) | 2017-06-14 |
| EP3177281B1 (en) | 2023-12-06 |
| TW201609084A (zh) | 2016-03-16 |
| TWI727926B (zh) | 2021-05-21 |
| MA40417A (fr) | 2017-06-14 |
| US20170224645A1 (en) | 2017-08-10 |
| CO2017001088A2 (es) | 2017-04-28 |
| CA2957700C (en) | 2022-12-13 |
| FI3177281T3 (fi) | 2024-03-13 |
| IL250271A0 (en) | 2017-03-30 |
| US9962355B2 (en) | 2018-05-08 |
| DK3177281T3 (da) | 2024-03-11 |
| US20180243254A1 (en) | 2018-08-30 |
| JP2021004260A (ja) | 2021-01-14 |
| CA2957700A1 (en) | 2016-02-11 |
| BR112017002474A2 (pt) | 2017-12-05 |
| JP7118642B2 (ja) | 2022-08-16 |
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