TWI689310B - 治療鐵缺乏症之方法 - Google Patents
治療鐵缺乏症之方法 Download PDFInfo
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- TWI689310B TWI689310B TW104120956A TW104120956A TWI689310B TW I689310 B TWI689310 B TW I689310B TW 104120956 A TW104120956 A TW 104120956A TW 104120956 A TW104120956 A TW 104120956A TW I689310 B TWI689310 B TW I689310B
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- Prior art keywords
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- iron oxide
- biocompatible
- use according
- oxide nanoparticles
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- 206010022971 Iron Deficiencies Diseases 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title abstract description 20
- 229940031182 nanoparticles iron oxide Drugs 0.000 claims abstract description 27
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 23
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical group [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 claims abstract description 19
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 125000003827 glycol group Chemical group 0.000 claims abstract description 9
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
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- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 11
- 125000005647 linker group Chemical group 0.000 claims description 9
- 125000001931 aliphatic group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
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- 125000003277 amino group Chemical group 0.000 claims description 2
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 35
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 8
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- 229920001427 mPEG Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
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- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 3
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
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| CN110157000B (zh) * | 2018-02-12 | 2022-05-31 | 巨生生医股份有限公司 | 生物相容性磁性材料 |
| JP2025537773A (ja) | 2022-11-10 | 2025-11-20 | ユニベルシテ ドゥ ロレーヌ | 鉄ナノクラスター、それを得る方法及び鉄欠乏症への対処におけるその使用 |
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| CN102112158A (zh) * | 2008-04-22 | 2011-06-29 | 财团法人工业技术研究院 | 生物相容性高分子与具有生物相容性的磁性纳米微粒 |
| WO2013150118A1 (en) * | 2012-04-04 | 2013-10-10 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticles dispersion, its preparation and diagnostic and therapeutic use |
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| US6099852A (en) * | 1998-09-23 | 2000-08-08 | Johnson & Johnson Vision Products, Inc. | Wettable silicone-based lenses |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| JP5064612B2 (ja) | 1999-04-09 | 2012-10-31 | エーエムエージー ファーマシューティカルズ，インコーポレイテッド | 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄 |
| US6997863B2 (en) * | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US20030190355A1 (en) | 2002-04-05 | 2003-10-09 | Hermelin Marc S. | Modified release minerals |
| ATE344289T1 (de) * | 2002-07-24 | 2006-11-15 | Hoffmann La Roche | Polyethylenglykol-aldehydderivate |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| CA2611985C (en) | 2005-06-17 | 2016-08-16 | The University Of North Carolina At Chapel Hill | Nanoparticle fabrication methods, systems, and materials |
| DE102005059751A1 (de) | 2005-12-09 | 2007-06-14 | Ferropharm Gmbh Forschungslabor | Wässrige Dispersion von superparamagnetischen Eindomänenteilchen, deren Herstellung und Verwendung zur Diagnose und Therapie |
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| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| TWI321133B (en) | 2006-08-01 | 2010-03-01 | Univ Kaohsiung Medical | Folate-receptor-targeting iron oxide nanoparticles coated with poly(ethylene glycol) |
| ES2308901B1 (es) | 2006-09-22 | 2009-10-30 | Consejo Superior De Investigaciones Cientificas | Sistemas que contienen nanoparticulas magneticas y polimeros, como nanocomposites y ferrofluidos, y sus aplicaciones. |
| US20110104073A1 (en) | 2007-01-18 | 2011-05-05 | Qi Zeng | Iron/Iron Oxide Nanoparticle and Use Thereof |
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| US20090280063A1 (en) | 2008-05-09 | 2009-11-12 | General Electric Company | Novel pei-peg graft copolymer coating of iron oxide nanoparticles for inflammation imaging |
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| WO2010034319A1 (en) * | 2008-09-29 | 2010-04-01 | Innovative Research And Development Co. (Inrad) | Magnetite nanoparticles as a single dose treatment for iron deficiency anemia |
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| EP2526927A1 (de) * | 2011-05-25 | 2012-11-28 | Justus-Liebig-Universität Gießen | Biokompatible Nano- und Mikropartikel beschichtet mit Stabilisatoren für die pulmonale Applikation |
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| CN103303981B (zh) | 2013-07-04 | 2015-04-01 | 厦门大学 | 一种四氧化三铁纳米粒子及其制备方法和用途 |
| CN103405790B (zh) | 2013-07-15 | 2015-05-20 | 中国科学院过程工程研究所 | 一种高分子原位修饰的超顺磁性颗粒、制备方法及其用途 |
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- 2015-07-10 CN CN201580035310.XA patent/CN107073035B/zh active Active
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- 2015-07-10 WO PCT/CN2015/083765 patent/WO2016004894A1/en not_active Ceased
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102112158A (zh) * | 2008-04-22 | 2011-06-29 | 财团法人工业技术研究院 | 生物相容性高分子与具有生物相容性的磁性纳米微粒 |
| WO2013150118A1 (en) * | 2012-04-04 | 2013-10-10 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticles dispersion, its preparation and diagnostic and therapeutic use |
Also Published As
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| EP2965754B1 (en) | 2017-10-04 |
| US20160008292A1 (en) | 2016-01-14 |
| JP6630293B2 (ja) | 2020-01-15 |
| CN107073035B (zh) | 2020-08-28 |
| TW201625278A (zh) | 2016-07-16 |
| CN107073035A (zh) | 2017-08-18 |
| EP2965754A1 (en) | 2016-01-13 |
| WO2016004894A1 (en) | 2016-01-14 |
| US9492399B2 (en) | 2016-11-15 |
| ES2654429T3 (es) | 2018-02-13 |
| JP2017524670A (ja) | 2017-08-31 |
| HUE035242T2 (en) | 2018-05-02 |
| PT2965754T (pt) | 2018-01-08 |
| PL2965754T3 (pl) | 2018-04-30 |
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