TWI689310B - 治療鐵缺乏症之方法 - Google Patents
治療鐵缺乏症之方法 Download PDFInfo
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- TWI689310B TWI689310B TW104120956A TW104120956A TWI689310B TW I689310 B TWI689310 B TW I689310B TW 104120956 A TW104120956 A TW 104120956A TW 104120956 A TW104120956 A TW 104120956A TW I689310 B TWI689310 B TW I689310B
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- Prior art keywords
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- iron oxide
- biocompatible
- use according
- oxide nanoparticles
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- 206010022971 Iron Deficiencies Diseases 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title abstract description 20
- 229940031182 nanoparticles iron oxide Drugs 0.000 claims abstract description 27
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 23
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical group [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 claims abstract description 19
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 125000003827 glycol group Chemical group 0.000 claims abstract description 9
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 15
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- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 11
- 125000005647 linker group Chemical group 0.000 claims description 9
- 125000001931 aliphatic group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
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- 125000003277 amino group Chemical group 0.000 claims description 2
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 35
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 8
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- 229920001427 mPEG Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
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- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 3
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
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| CN110157000B (zh) | 2018-02-12 | 2022-05-31 | 巨生生医股份有限公司 | 生物相容性磁性材料 |
| WO2024100213A1 (fr) | 2022-11-10 | 2024-05-16 | Université De Lorraine | Nanoclusters de fer, leurs procédés d'obtention et leurs utilisations pour lutter contre les carences en fer |
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| WO2013150118A1 (en) * | 2012-04-04 | 2013-10-10 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticles dispersion, its preparation and diagnostic and therapeutic use |
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| US5554386A (en) | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US6099852A (en) * | 1998-09-23 | 2000-08-08 | Johnson & Johnson Vision Products, Inc. | Wettable silicone-based lenses |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| DE60043188D1 (de) | 1999-04-09 | 2009-12-03 | Amag Pharmaceuticals Inc | Hitzebeständige umhüllte kolloidale eisenoxide |
| US6997863B2 (en) * | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| US20030190355A1 (en) | 2002-04-05 | 2003-10-09 | Hermelin Marc S. | Modified release minerals |
| AU2003250971B2 (en) * | 2002-07-24 | 2008-04-03 | F. Hoffmann - La Roche Ag | Polyethylene glycol aldehyde derivatives |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| US20110182805A1 (en) | 2005-06-17 | 2011-07-28 | Desimone Joseph M | Nanoparticle fabrication methods, systems, and materials |
| DE102005059751A1 (de) | 2005-12-09 | 2007-06-14 | Ferropharm Gmbh Forschungslabor | Wässrige Dispersion von superparamagnetischen Eindomänenteilchen, deren Herstellung und Verwendung zur Diagnose und Therapie |
| TWI293113B (en) | 2005-12-23 | 2008-02-01 | Ind Tech Res Inst | Magnetic nanoparticles with fluorescent and specific targeting functions |
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| TWI321133B (en) | 2006-08-01 | 2010-03-01 | Univ Kaohsiung Medical | Folate-receptor-targeting iron oxide nanoparticles coated with poly(ethylene glycol) |
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| US20090280063A1 (en) | 2008-05-09 | 2009-11-12 | General Electric Company | Novel pei-peg graft copolymer coating of iron oxide nanoparticles for inflammation imaging |
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| WO2010034319A1 (en) * | 2008-09-29 | 2010-04-01 | Innovative Research And Development Co. (Inrad) | Magnetite nanoparticles as a single dose treatment for iron deficiency anemia |
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| WO2010091183A2 (en) | 2009-02-04 | 2010-08-12 | The Regents Of The University Of Colorado, A Body Corporate | Non-invasive detection of complement-mediated inflammation using cr2-targeted nanoparticles |
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| WO2011052205A1 (ja) * | 2009-10-30 | 2011-05-05 | 国立大学法人東京工業大学 | ポリマー被覆フェライト微粒子および製造方法 |
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| EP2526927A1 (de) * | 2011-05-25 | 2012-11-28 | Justus-Liebig-Universität Gießen | Biokompatible Nano- und Mikropartikel beschichtet mit Stabilisatoren für die pulmonale Applikation |
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| CN103303981B (zh) | 2013-07-04 | 2015-04-01 | 厦门大学 | 一种四氧化三铁纳米粒子及其制备方法和用途 |
| CN103405790B (zh) | 2013-07-15 | 2015-05-20 | 中国科学院过程工程研究所 | 一种高分子原位修饰的超顺磁性颗粒、制备方法及其用途 |
| CN103469290B (zh) | 2013-09-02 | 2016-01-13 | 南阳师范学院 | 一种合成超顺磁性Fe3O4纳米晶的方法 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102112158A (zh) * | 2008-04-22 | 2011-06-29 | 财团法人工业技术研究院 | 生物相容性高分子与具有生物相容性的磁性纳米微粒 |
| WO2013150118A1 (en) * | 2012-04-04 | 2013-10-10 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticles dispersion, its preparation and diagnostic and therapeutic use |
Also Published As
| Publication number | Publication date |
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| CN107073035A (zh) | 2017-08-18 |
| WO2016004894A1 (en) | 2016-01-14 |
| US9492399B2 (en) | 2016-11-15 |
| PL2965754T3 (pl) | 2018-04-30 |
| US20160008292A1 (en) | 2016-01-14 |
| JP6630293B2 (ja) | 2020-01-15 |
| PT2965754T (pt) | 2018-01-08 |
| EP2965754A1 (en) | 2016-01-13 |
| ES2654429T3 (es) | 2018-02-13 |
| TW201625278A (zh) | 2016-07-16 |
| CN107073035B (zh) | 2020-08-28 |
| HUE035242T2 (en) | 2018-05-02 |
| JP2017524670A (ja) | 2017-08-31 |
| EP2965754B1 (en) | 2017-10-04 |
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