TWI685347B - 用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 - Google Patents

用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 Download PDF

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TWI685347B
TWI685347B TW103127144A TW103127144A TWI685347B TW I685347 B TWI685347 B TW I685347B TW 103127144 A TW103127144 A TW 103127144A TW 103127144 A TW103127144 A TW 103127144A TW I685347 B TWI685347 B TW I685347B
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polymer
peg
rgd
mmol
fmoc
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TW103127144A
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TW201601742A (zh
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為軍 承
素珍 黃
艾倫Ｍ 艾爾梅達
大衛Ｂ 羅薩馬
安卓Ｖ 布洛克希
傑佛瑞Ｃ 卡爾森
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愛羅海德製藥公司
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • C07K5/08—Tripeptides
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TW103127144A 2013-08-07 2014-08-07 用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 TWI685347B (zh)

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US201361863056P 2013-08-07 2013-08-07
US61/863,056 2013-08-07

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TW201601742A TW201601742A (zh) 2016-01-16
TWI685347B true TWI685347B (zh) 2020-02-21

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US (3) US9487556B2 (enExample)
EP (1) EP3030244B1 (enExample)
JP (1) JP6433001B2 (enExample)
KR (1) KR20160035081A (enExample)
CN (1) CN105451743B (enExample)
AU (1) AU2014306021B2 (enExample)
CA (1) CA2919088A1 (enExample)
EA (1) EA201690051A1 (enExample)
IL (1) IL243941B (enExample)
MX (1) MX2016001006A (enExample)
SG (1) SG11201600379TA (enExample)
TW (1) TWI685347B (enExample)
WO (1) WO2015021092A1 (enExample)

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CA2979703A1 (en) 2015-03-17 2016-09-22 Arrowhead Pharmaceuticals, Inc. Compositions and methods for inhibiting gene expression of factor xii
EP3270903B1 (en) 2015-03-17 2020-05-06 Arrowhead Pharmaceuticals, Inc. Disulfide-containing alkyne linking agents
SG10202105989WA (en) 2015-05-29 2021-07-29 Arrowhead Pharmaceuticals Inc Compositions and methods for inhibiting gene expression of hif2alpha
WO2016196243A1 (en) 2015-05-29 2016-12-08 Arrowhead Pharmaceuticals, Inc. Biologically cleavable tetrapeptide linking agents
JOP20160211B1 (ar) 2015-10-01 2021-08-17 Arrowhead Pharmaceuticals Inc تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
EP3252082A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Method for deacetylation of biopolymers
DK4279537T3 (da) 2015-12-29 2026-04-20 Galderma Holding SA Kulhydrat-tværbinder
PT3623390T (pt) * 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
CN118652192A (zh) 2017-05-24 2024-09-17 德克萨斯州大学系统董事会 用于抗体药物缀合物的接头
WO2019210200A1 (en) 2018-04-27 2019-10-31 Arrowhead Pharmaceuticals, Inc. Integrin targeting ligands and uses thereof
EP3908288A4 (en) 2019-01-09 2023-12-20 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
CN110240551B (zh) * 2019-06-25 2022-02-11 成都郑源生化科技有限公司 Fmoc-β-Ala-Gly-OH的制备方法
EP4069753A1 (en) 2019-12-02 2022-10-12 Galderma Holding SA High molecular weight esthetic compositions
CN113004515B (zh) * 2021-03-02 2023-02-24 厦门大学附属中山医院 一种仿透明质酸聚氨基酸衍生物、其制备方法及其应用

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EP3030244A1 (en) 2016-06-15
AU2014306021A1 (en) 2016-01-28
US9487556B2 (en) 2016-11-08
AU2014306021B2 (en) 2018-12-13
KR20160035081A (ko) 2016-03-30
EP3030244A4 (en) 2017-06-28
HK1220397A1 (zh) 2017-05-05
EP3030244B1 (en) 2021-04-21
US20190062748A1 (en) 2019-02-28
IL243941B (en) 2019-06-30
CA2919088A1 (en) 2015-02-12
WO2015021092A1 (en) 2015-02-12
CN105451743B (zh) 2019-11-19
SG11201600379TA (en) 2016-02-26
IL243941A0 (en) 2016-04-21
CN105451743A (zh) 2016-03-30
EA201690051A1 (ru) 2016-06-30
US20170022497A1 (en) 2017-01-26
TW201601742A (zh) 2016-01-16
MX2016001006A (es) 2016-04-19
JP2016535058A (ja) 2016-11-10
US20150045573A1 (en) 2015-02-12
JP6433001B2 (ja) 2018-12-05
AU2014306021A2 (en) 2016-11-24

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