EA201690051A1 - Поликонъюгаты для доставки триггеров рнк интерференции в клетки опухоли in vivo - Google Patents

Поликонъюгаты для доставки триггеров рнк интерференции в клетки опухоли in vivo

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Publication number
EA201690051A1
EA201690051A1 EA201690051A EA201690051A EA201690051A1 EA 201690051 A1 EA201690051 A1 EA 201690051A1 EA 201690051 A EA201690051 A EA 201690051A EA 201690051 A EA201690051 A EA 201690051A EA 201690051 A1 EA201690051 A1 EA 201690051A1
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EA
Eurasian Patent Office
Prior art keywords
polyconjugates
tumor
delivery
rnai
trigger
Prior art date
Application number
EA201690051A
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English (en)
Inventor
Вэйцзюнь Чэн
Со Вон
Аарон М. Альмейда
Дэвид Б. Розема
Андрей В. Блохин
Джеффри С. Карлсон
Original Assignee
Эрроухэд Рисерч Корпорейшн
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Application filed by Эрроухэд Рисерч Корпорейшн filed Critical Эрроухэд Рисерч Корпорейшн
Publication of EA201690051A1 publication Critical patent/EA201690051A1/ru

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
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    • C12N2310/3535—Nitrogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Chemical & Material Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

В данном изобретении предложены композиции для доставки триггера РНК-интерференции (РНКи) в интегрин-положительные опухолевые клетки in vivo. Композиции содержат нацеленные на RGD-лиганд амфипатические мембранно-активные полиамины, обратимо модифицированные с помощью расщепляемых ферментом дипептид-амидобензил-карбонат маскирующих агентов. Модификация маскирует мембранную активность полимера, тогда как обратимость обеспечивает способность реагировать на физиологические условия. Обратимо модифицированные полиамины (динамический поликонъюгат или конъюгат) дополнительно ковалентно соединены с триггером РНКи.
EA201690051A 2013-08-07 2014-08-06 Поликонъюгаты для доставки триггеров рнк интерференции в клетки опухоли in vivo EA201690051A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863056P 2013-08-07 2013-08-07
US14/452,626 US9487556B2 (en) 2013-08-07 2014-08-06 Polyconjugates for delivery of RNAi triggers to tumor cells in vivo
PCT/US2014/049851 WO2015021092A1 (en) 2013-08-07 2014-08-06 Polyconjugates for delivery of rnai triggers to tumor cells in vivo

Publications (1)

Publication Number Publication Date
EA201690051A1 true EA201690051A1 (ru) 2016-06-30

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EA201690051A EA201690051A1 (ru) 2013-08-07 2014-08-06 Поликонъюгаты для доставки триггеров рнк интерференции в клетки опухоли in vivo

Country Status (14)

Country Link
US (3) US9487556B2 (ru)
EP (1) EP3030244B1 (ru)
JP (1) JP6433001B2 (ru)
KR (1) KR20160035081A (ru)
CN (1) CN105451743B (ru)
AU (1) AU2014306021B2 (ru)
CA (1) CA2919088A1 (ru)
EA (1) EA201690051A1 (ru)
HK (1) HK1220397A1 (ru)
IL (1) IL243941B (ru)
MX (1) MX2016001006A (ru)
SG (1) SG11201600379TA (ru)
TW (1) TWI685347B (ru)
WO (1) WO2015021092A1 (ru)

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US20170022497A1 (en) 2017-01-26
IL243941A0 (en) 2016-04-21
CN105451743A (zh) 2016-03-30
CA2919088A1 (en) 2015-02-12
AU2014306021B2 (en) 2018-12-13
EP3030244A4 (en) 2017-06-28
JP6433001B2 (ja) 2018-12-05
KR20160035081A (ko) 2016-03-30
US20150045573A1 (en) 2015-02-12
WO2015021092A1 (en) 2015-02-12
JP2016535058A (ja) 2016-11-10
MX2016001006A (es) 2016-04-19
US9487556B2 (en) 2016-11-08
EP3030244B1 (en) 2021-04-21
US20190062748A1 (en) 2019-02-28
AU2014306021A2 (en) 2016-11-24
AU2014306021A1 (en) 2016-01-28
EP3030244A1 (en) 2016-06-15
SG11201600379TA (en) 2016-02-26
CN105451743B (zh) 2019-11-19
TW201601742A (zh) 2016-01-16
TWI685347B (zh) 2020-02-21
IL243941B (en) 2019-06-30
HK1220397A1 (zh) 2017-05-05

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