TWI677510B - 聚合物與奈米凝膠材料及其製造與使用方法 - Google Patents

Info

Publication number

TWI677510B

TWI677510B TW102118351A TW102118351A TWI677510B TW I677510 B TWI677510 B TW I677510B TW 102118351 A TW102118351 A TW 102118351A TW 102118351 A TW102118351 A TW 102118351A TW I677510 B TWI677510 B TW I677510B

Authority

TW

Taiwan

Prior art keywords

group

block copolymer

substituted

vinyl

unsubstituted

Prior art date

2012-05-25

Links

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• Global Dossier
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• 229920000642 polymer Polymers 0.000 title claims abstract description 143
• 238000000034 method Methods 0.000 title claims description 48
• 239000000463 material Substances 0.000 title description 18
• 229920001296 polysiloxane Polymers 0.000 claims abstract description 152
• 229920001400 block copolymer Polymers 0.000 claims abstract description 128
• 239000000178 monomer Substances 0.000 claims abstract description 114
• 239000000203 mixture Substances 0.000 claims abstract description 74
• 238000006116 polymerization reaction Methods 0.000 claims abstract description 54
• 230000002209 hydrophobic effect Effects 0.000 claims abstract description 20
• 125000005647 linker group Chemical group 0.000 claims abstract description 14
• 238000007334 copolymerization reaction Methods 0.000 claims abstract description 6
• -1 polysiloxane Polymers 0.000 claims description 278
• 239000000243 solution Substances 0.000 claims description 104
• 239000003431 cross linking reagent Substances 0.000 claims description 56
• 125000000217 alkyl group Chemical group 0.000 claims description 40
• 239000012987 RAFT agent Substances 0.000 claims description 38
• 238000010521 absorption reaction Methods 0.000 claims description 37
• 239000011541 reaction mixture Substances 0.000 claims description 37
• AISZNMCRXZWVAT-UHFFFAOYSA-N 2-ethylsulfanylcarbothioylsulfanyl-2-methylpropanenitrile Chemical compound CCSC(=S)SC(C)(C)C#N AISZNMCRXZWVAT-UHFFFAOYSA-N 0.000 claims description 35
• 229910052757 nitrogen Inorganic materials 0.000 claims description 35
• 125000000524 functional group Chemical group 0.000 claims description 33
• 239000003999 initiator Substances 0.000 claims description 33
• 150000002632 lipids Chemical class 0.000 claims description 33
• 150000003254 radicals Chemical class 0.000 claims description 33
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 28
• 229910052739 hydrogen Inorganic materials 0.000 claims description 26
• 125000004432 carbon atom Chemical group C* 0.000 claims description 24
• 238000002360 preparation method Methods 0.000 claims description 24
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 22
• 239000002253 acid Substances 0.000 claims description 22
• 239000001257 hydrogen Substances 0.000 claims description 21
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 21
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 20
• 125000003118 aryl group Chemical group 0.000 claims description 19
• NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 18
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 16
• 239000002997 ophthalmic solution Substances 0.000 claims description 14
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 12
• 229910052799 carbon Inorganic materials 0.000 claims description 12
• 229910052736 halogen Inorganic materials 0.000 claims description 12
• 150000002367 halogens Chemical class 0.000 claims description 12
• 229940054534 ophthalmic solution Drugs 0.000 claims description 12
• 229910052760 oxygen Inorganic materials 0.000 claims description 12
• 229920001223 polyethylene glycol Polymers 0.000 claims description 12
• KCXFHTAICRTXLI-UHFFFAOYSA-M propane-1-sulfonate Chemical compound CCCS([O-])(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-M 0.000 claims description 12
• 125000002947 alkylene group Chemical group 0.000 claims description 11
• 239000002202 Polyethylene glycol Substances 0.000 claims description 10
• 150000002148 esters Chemical group 0.000 claims description 10
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 10
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
• 238000010526 radical polymerization reaction Methods 0.000 claims description 10
• 125000001424 substituent group Chemical group 0.000 claims description 10
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
• 125000003545 alkoxy group Chemical group 0.000 claims description 9
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 9
• 239000011734 sodium Substances 0.000 claims description 9
• 125000000623 heterocyclic group Chemical group 0.000 claims description 8
• YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims description 8
• 238000012546 transfer Methods 0.000 claims description 8
• KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 7
• 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims description 7
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
• 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 6
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
• 125000004414 alkyl thio group Chemical group 0.000 claims description 6
• 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
• PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 claims description 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
• 229910052708 sodium Inorganic materials 0.000 claims description 6
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
• 125000004122 cyclic group Chemical group 0.000 claims description 5
• UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 claims description 5
• NLVXSWCKKBEXTG-UHFFFAOYSA-M ethenesulfonate Chemical compound [O-]S(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-M 0.000 claims description 5
• JFUWJIKJUNAHEN-UHFFFAOYSA-N 1-ethenyl-3-ethylpyrrolidin-2-one Chemical compound CCC1CCN(C=C)C1=O JFUWJIKJUNAHEN-UHFFFAOYSA-N 0.000 claims description 4
• SBEBZMZHYUEOPQ-UHFFFAOYSA-N 1-ethenyl-3-methylpiperidin-2-one Chemical compound CC1CCCN(C=C)C1=O SBEBZMZHYUEOPQ-UHFFFAOYSA-N 0.000 claims description 4
• HKOOECSKKYAKJJ-UHFFFAOYSA-N 1-ethenyl-3-pentan-2-ylaziridin-2-one Chemical compound CCCC(C)C1N(C=C)C1=O HKOOECSKKYAKJJ-UHFFFAOYSA-N 0.000 claims description 4
• CRJHKHYPIUPQSX-UHFFFAOYSA-N 1-ethenyl-4,5-dimethylpyrrolidin-2-one Chemical compound CC1CC(=O)N(C=C)C1C CRJHKHYPIUPQSX-UHFFFAOYSA-N 0.000 claims description 4
• PBGPBHYPCGDFEZ-UHFFFAOYSA-N 1-ethenylpiperidin-2-one Chemical compound C=CN1CCCCC1=O PBGPBHYPCGDFEZ-UHFFFAOYSA-N 0.000 claims description 4
• OVPDHQHCPIDSCP-UHFFFAOYSA-N 2-(4-sulfobutylidene)butanedioic acid Chemical compound OC(=O)CC(C(O)=O)=CCCCS(O)(=O)=O OVPDHQHCPIDSCP-UHFFFAOYSA-N 0.000 claims description 4
• NYEZZYQZRQDLEH-UHFFFAOYSA-N 2-ethyl-4,5-dihydro-1,3-oxazole Chemical compound CCC1=NCCO1 NYEZZYQZRQDLEH-UHFFFAOYSA-N 0.000 claims description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
• 125000003342 alkenyl group Chemical group 0.000 claims description 4
• 229910002091 carbon monoxide Inorganic materials 0.000 claims description 4
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 4
• 229960001231 choline Drugs 0.000 claims description 4
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
• 230000007246 mechanism Effects 0.000 claims description 4
• QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims description 4
• 229920006395 saturated elastomer Polymers 0.000 claims description 4
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
• HGMWQAGLTXDVEW-UHFFFAOYSA-N 1-ethenyl-3-(2-methylbutyl)aziridin-2-one Chemical compound CCC(C)CC1N(C=C)C1=O HGMWQAGLTXDVEW-UHFFFAOYSA-N 0.000 claims description 3
• JBKFPCSZNWLZAS-UHFFFAOYSA-N 1-ethenyl-4-methylpiperidin-2-one Chemical compound CC1CCN(C=C)C(=O)C1 JBKFPCSZNWLZAS-UHFFFAOYSA-N 0.000 claims description 3
• OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims description 3
• QKPKBBFSFQAMIY-UHFFFAOYSA-N 2-ethenyl-4,4-dimethyl-1,3-oxazol-5-one Chemical compound CC1(C)N=C(C=C)OC1=O QKPKBBFSFQAMIY-UHFFFAOYSA-N 0.000 claims description 3
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 3
• AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 claims description 3
• IHPNWTRBZGWGER-UHFFFAOYSA-N 2-phosphanylethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCP IHPNWTRBZGWGER-UHFFFAOYSA-N 0.000 claims description 3
• MEVLIJVLXBOGSQ-UHFFFAOYSA-N 3-(ethenoxycarbonylamino)propanoic acid Chemical compound OC(=O)CCNC(=O)OC=C MEVLIJVLXBOGSQ-UHFFFAOYSA-N 0.000 claims description 3
• GAVHQOUUSHBDAA-UHFFFAOYSA-N 3-butyl-1-ethenylaziridin-2-one Chemical compound CCCCC1N(C=C)C1=O GAVHQOUUSHBDAA-UHFFFAOYSA-N 0.000 claims description 3
• SBVKVAIECGDBTC-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanamide Chemical compound NC(=O)C(=C)CCO SBVKVAIECGDBTC-UHFFFAOYSA-N 0.000 claims description 3
• IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 claims description 3
• NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 3
• BKHXSCWISZIORU-UHFFFAOYSA-N C(C=C)(=O)NNC(CC(=O)O)(C)C Chemical compound C(C=C)(=O)NNC(CC(=O)O)(C)C BKHXSCWISZIORU-UHFFFAOYSA-N 0.000 claims description 3
• IAMQWAHOWVRBCN-UHFFFAOYSA-N C(C=C)(=O)NNCCCCC(=O)O Chemical compound C(C=C)(=O)NNCCCCC(=O)O IAMQWAHOWVRBCN-UHFFFAOYSA-N 0.000 claims description 3
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
• 239000004593 Epoxy Substances 0.000 claims description 3
• 239000005977 Ethylene Substances 0.000 claims description 3
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical class CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 3
• XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 3
• 150000001733 carboxylic acid esters Chemical class 0.000 claims description 3
• 239000000460 chlorine Substances 0.000 claims description 3
• 229910052801 chlorine Inorganic materials 0.000 claims description 3
• 125000005265 dialkylamine group Chemical group 0.000 claims description 3
• KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims description 3
• 239000011737 fluorine Substances 0.000 claims description 3
• 229910052731 fluorine Inorganic materials 0.000 claims description 3
• 239000012948 isocyanate Substances 0.000 claims description 3
• 150000002513 isocyanates Chemical class 0.000 claims description 3
• XUQIDBSIIKXTTI-UHFFFAOYSA-N n,n-bis(2-hydroxyethyl)prop-2-enamide Chemical compound OCCN(CCO)C(=O)C=C XUQIDBSIIKXTTI-UHFFFAOYSA-N 0.000 claims description 3
• ZTUGCJNAJJDKDC-UHFFFAOYSA-N n-(3-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCCO ZTUGCJNAJJDKDC-UHFFFAOYSA-N 0.000 claims description 3
• 229910052700 potassium Inorganic materials 0.000 claims description 3
• 239000011591 potassium Substances 0.000 claims description 3
• 229910052717 sulfur Inorganic materials 0.000 claims description 3
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 2
• XRUKRHLZDVJJSX-UHFFFAOYSA-N 4-cyanopentanoic acid Chemical class N#CC(C)CCC(O)=O XRUKRHLZDVJJSX-UHFFFAOYSA-N 0.000 claims description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
• AWPVOJRMGUHMNX-UHFFFAOYSA-N C(C=C)(=O)NNCCCC(=O)O Chemical compound C(C=C)(=O)NNCCCC(=O)O AWPVOJRMGUHMNX-UHFFFAOYSA-N 0.000 claims description 2
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
• 125000004104 aryloxy group Chemical group 0.000 claims description 2
• 125000004429 atom Chemical group 0.000 claims description 2
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 2
• 150000007942 carboxylates Chemical class 0.000 claims description 2
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
• 125000000959 isobutyl group Chemical class [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
• XLMRRLLWLSMZLN-UHFFFAOYSA-N n-ethenyl-2-methylpropan-1-amine Chemical compound CC(C)CNC=C XLMRRLLWLSMZLN-UHFFFAOYSA-N 0.000 claims description 2
• YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 claims description 2
• 229910052698 phosphorus Inorganic materials 0.000 claims description 2
• HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 2
• 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims description 2
• 125000005156 substituted alkylene group Chemical group 0.000 claims description 2
• 150000003459 sulfonic acid esters Chemical class 0.000 claims description 2
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
• OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims 1
• OPRIWFSSXKQMPB-UHFFFAOYSA-N 2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid;sodium Chemical compound [Na].OS(=O)(=O)CC(C)(C)NC(=O)C=C OPRIWFSSXKQMPB-UHFFFAOYSA-N 0.000 claims 1
• 101150107995 ACA1 gene Proteins 0.000 claims 1
• PMSFXVWXTQGIIL-UHFFFAOYSA-N CC=CNCCC(O)=O Chemical compound CC=CNCCC(O)=O PMSFXVWXTQGIIL-UHFFFAOYSA-N 0.000 claims 1
• QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• VSCSDGQSSJNPSD-UHFFFAOYSA-N N-ethenyl-N,2-dimethylpropan-1-amine Chemical compound CC(CN(C=C)C)C VSCSDGQSSJNPSD-UHFFFAOYSA-N 0.000 claims 1
• NHISOSFLESCFIC-UHFFFAOYSA-N n-(2-hydroxypropyl)-n-methylprop-2-enamide Chemical compound CC(O)CN(C)C(=O)C=C NHISOSFLESCFIC-UHFFFAOYSA-N 0.000 claims 1
• CXIAYEXSJBONCV-UHFFFAOYSA-N n-ethenyl-n-methylpropan-1-amine Chemical compound CCCN(C)C=C CXIAYEXSJBONCV-UHFFFAOYSA-N 0.000 claims 1
• LQJARUQXWJSDFL-UHFFFAOYSA-N phenamine Chemical compound CCOC1=CC=C(NC(=O)CN)C=C1 LQJARUQXWJSDFL-UHFFFAOYSA-N 0.000 claims 1
• 229950010879 phenamine Drugs 0.000 claims 1
• 230000000379 polymerizing effect Effects 0.000 claims 1
• KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims 1
• BWYYYTVSBPRQCN-UHFFFAOYSA-M sodium;ethenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C=C BWYYYTVSBPRQCN-UHFFFAOYSA-M 0.000 claims 1
• 239000011159 matrix material Substances 0.000 abstract description 57
• 239000000017 hydrogel Substances 0.000 abstract description 51
• 238000009472 formulation Methods 0.000 abstract description 4
• 238000006243 chemical reaction Methods 0.000 description 68
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 37
• 239000002953 phosphate buffered saline Substances 0.000 description 37
• 238000004132 cross linking Methods 0.000 description 29
• 239000003795 chemical substances by application Substances 0.000 description 27
• 229920001577 copolymer Polymers 0.000 description 27
• 239000004615 ingredient Substances 0.000 description 27
• 239000004417 polycarbonate Substances 0.000 description 27
• 150000001875 compounds Chemical class 0.000 description 25
• VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 24
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
• 239000000080 wetting agent Substances 0.000 description 23
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 21
• 239000004205 dimethyl polysiloxane Substances 0.000 description 20
• 238000004806 packaging method and process Methods 0.000 description 20
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 20
• 238000012360 testing method Methods 0.000 description 18
• 102000007592 Apolipoproteins Human genes 0.000 description 15
• 108010071619 Apolipoproteins Proteins 0.000 description 15
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
• 239000002904 solvent Substances 0.000 description 15
• 230000015572 biosynthetic process Effects 0.000 description 14
• 239000003085 diluting agent Substances 0.000 description 14
• 230000003287 optical effect Effects 0.000 description 14
• 238000012712 reversible addition−fragmentation chain-transfer polymerization Methods 0.000 description 14
• 235000019441 ethanol Nutrition 0.000 description 13
• 230000002829 reductive effect Effects 0.000 description 13
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
• 102000016943 Muramidase Human genes 0.000 description 12
• 108010014251 Muramidase Proteins 0.000 description 12
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 12
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 12
• 239000004325 lysozyme Substances 0.000 description 12
• 235000010335 lysozyme Nutrition 0.000 description 12
• 229960000274 lysozyme Drugs 0.000 description 12
• 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 12
• 229910052710 silicon Inorganic materials 0.000 description 12
• 239000004971 Cross linker Substances 0.000 description 11
• 150000001412 amines Chemical class 0.000 description 11
• 239000010703 silicon Substances 0.000 description 11
• 239000000758 substrate Substances 0.000 description 11
• 229920002554 vinyl polymer Polymers 0.000 description 11
• 102000015728 Mucins Human genes 0.000 description 10
• 108010063954 Mucins Proteins 0.000 description 10
• AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 10
• 239000012634 fragment Substances 0.000 description 10
• 230000009257 reactivity Effects 0.000 description 10
• 235000002639 sodium chloride Nutrition 0.000 description 10
• 239000000126 substance Substances 0.000 description 10
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
• LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 9
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
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