TWI670271B - [1,2,4]三唑并[4,3-a]吡-6(5h)-酮衍生物 - Google Patents

[1,2,4]三唑并[4,3-a]吡-6(5h)-酮衍生物 Download PDF

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Publication number
TWI670271B
TWI670271B TW107124931A TW107124931A TWI670271B TW I670271 B TWI670271 B TW I670271B TW 107124931 A TW107124931 A TW 107124931A TW 107124931 A TW107124931 A TW 107124931A TW I670271 B TWI670271 B TW I670271B
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TW
Taiwan
Prior art keywords
compound
methyl
mmol
pharmaceutically acceptable
pyrido
Prior art date
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TW107124931A
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English (en)
Chinese (zh)
Other versions
TW201920175A (zh
Inventor
麥可 詹姆斯 傑寧
威廉 葛林 赫樓威
理察 度安 約翰斯東
約翰 理查 墨非
勤 徐
Original Assignee
美商美國禮來大藥廠
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Application filed by 美商美國禮來大藥廠 filed Critical 美商美國禮來大藥廠
Publication of TW201920175A publication Critical patent/TW201920175A/zh
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Publication of TWI670271B publication Critical patent/TWI670271B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW107124931A 2017-08-02 2018-07-19 [1,2,4]三唑并[4,3-a]吡-6(5h)-酮衍生物 TWI670271B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762540122P 2017-08-02 2017-08-02
US62/540,122 2017-08-02

Publications (2)

Publication Number Publication Date
TW201920175A TW201920175A (zh) 2019-06-01
TWI670271B true TWI670271B (zh) 2019-09-01

Family

ID=63165529

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107124931A TWI670271B (zh) 2017-08-02 2018-07-19 [1,2,4]三唑并[4,3-a]吡-6(5h)-酮衍生物

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Country Link
US (1) US11180503B2 (https=)
EP (1) EP3661936B1 (https=)
JP (1) JP6850396B2 (https=)
CN (1) CN110914268B (https=)
AR (1) AR112457A1 (https=)
ES (1) ES2904938T3 (https=)
TW (1) TWI670271B (https=)
WO (1) WO2019027783A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
AU2024341364A1 (en) 2023-09-14 2026-03-26 Eli Lilly And Company Pde1 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048556A1 (en) * 2006-12-13 2010-02-25 Makoto Okada Quinoxaline derivatives
WO2016055618A1 (en) * 2014-10-10 2016-04-14 H. Lundbeck A/S Triazolopyrazinones as pde1 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
WO2007150025A2 (en) * 2006-06-23 2007-12-27 Incyte Corporation Purinone derivatives as hm74a agonists
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
EP2509983B1 (en) * 2009-11-16 2014-09-17 Merck Sharp & Dohme Corp. FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY
BR112013005439A2 (pt) 2010-09-07 2017-09-19 Astellas Pharma Inc compostos de quinoxalina
CN103874701A (zh) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 吡啶化合物和其用途
MX357320B (es) 2012-06-18 2018-07-04 Dart Neuroscience Cayman Ltd Compuestos de la azolopirimidina-5-(6h)-ona de piridina sustituida.
US20140045856A1 (en) * 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
TWI609870B (zh) * 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
JOP20170164A1 (ar) * 2016-08-25 2019-01-30 Lilly Co Eli مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048556A1 (en) * 2006-12-13 2010-02-25 Makoto Okada Quinoxaline derivatives
WO2016055618A1 (en) * 2014-10-10 2016-04-14 H. Lundbeck A/S Triazolopyrazinones as pde1 inhibitors

Also Published As

Publication number Publication date
CN110914268B (zh) 2022-04-19
US11180503B2 (en) 2021-11-23
EP3661936B1 (en) 2021-12-22
TW201920175A (zh) 2019-06-01
AR112457A1 (es) 2019-10-30
CN110914268A (zh) 2020-03-24
EP3661936A1 (en) 2020-06-10
JP2020529413A (ja) 2020-10-08
ES2904938T3 (es) 2022-04-06
US20200123154A1 (en) 2020-04-23
JP6850396B2 (ja) 2021-03-31
WO2019027783A1 (en) 2019-02-07

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