CN110914268B - [1,2,4]三唑并[4,3-a]吡嗪-6(5H)-酮衍生物 - Google Patents

[1,2,4]三唑并[4,3-a]吡嗪-6(5H)-酮衍生物 Download PDF

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Publication number
CN110914268B
CN110914268B CN201880050277.1A CN201880050277A CN110914268B CN 110914268 B CN110914268 B CN 110914268B CN 201880050277 A CN201880050277 A CN 201880050277A CN 110914268 B CN110914268 B CN 110914268B
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China
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methyl
compound
mmol
pyrido
preparation
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CN201880050277.1A
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Chinese (zh)
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CN110914268A (zh
Inventor
M.J.格宁
W.G.霍罗伟
R.D.约翰斯顿
J.R.莫菲
施清
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880050277.1A 2017-08-02 2018-07-26 [1,2,4]三唑并[4,3-a]吡嗪-6(5H)-酮衍生物 Active CN110914268B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762540122P 2017-08-02 2017-08-02
US62/540122 2017-08-02
PCT/US2018/043845 WO2019027783A1 (en) 2017-08-02 2018-07-26 DERIVATIVES OF [1,2,4] TRIAZOLO [4,3-A] PYRAZIN-6 (5H) -ONE

Publications (2)

Publication Number Publication Date
CN110914268A CN110914268A (zh) 2020-03-24
CN110914268B true CN110914268B (zh) 2022-04-19

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CN201880050277.1A Active CN110914268B (zh) 2017-08-02 2018-07-26 [1,2,4]三唑并[4,3-a]吡嗪-6(5H)-酮衍生物

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US (1) US11180503B2 (https=)
EP (1) EP3661936B1 (https=)
JP (1) JP6850396B2 (https=)
CN (1) CN110914268B (https=)
AR (1) AR112457A1 (https=)
ES (1) ES2904938T3 (https=)
TW (1) TWI670271B (https=)
WO (1) WO2019027783A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
AU2024341364A1 (en) 2023-09-14 2026-03-26 Eli Lilly And Company Pde1 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011060207A1 (en) * 2009-11-16 2011-05-19 Schering Corporation FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY
CN103874701A (zh) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 吡啶化合物和其用途
CN106715438A (zh) * 2014-10-10 2017-05-24 H.隆德贝克有限公司 作为pde1抑制剂的三唑并吡嗪酮

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
WO2007150025A2 (en) * 2006-06-23 2007-12-27 Incyte Corporation Purinone derivatives as hm74a agonists
CA2671980C (en) * 2006-12-13 2015-05-05 Aska Pharmaceutical Co., Ltd. Quinoxaline derivatives
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
BR112013005439A2 (pt) 2010-09-07 2017-09-19 Astellas Pharma Inc compostos de quinoxalina
MX357320B (es) 2012-06-18 2018-07-04 Dart Neuroscience Cayman Ltd Compuestos de la azolopirimidina-5-(6h)-ona de piridina sustituida.
US20140045856A1 (en) * 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
TWI609870B (zh) * 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑
JOP20170164A1 (ar) * 2016-08-25 2019-01-30 Lilly Co Eli مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011060207A1 (en) * 2009-11-16 2011-05-19 Schering Corporation FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY
CN103874701A (zh) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 吡啶化合物和其用途
CN106715438A (zh) * 2014-10-10 2017-05-24 H.隆德贝克有限公司 作为pde1抑制剂的三唑并吡嗪酮

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Regioselective One-Pot Synthesis of 9-Alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo-[4,3-a]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides;Asier Unciti-Broceta;《J. Org. Chem.》;20050503;第70卷(第7期);2878-2880页 *

Also Published As

Publication number Publication date
US11180503B2 (en) 2021-11-23
EP3661936B1 (en) 2021-12-22
TW201920175A (zh) 2019-06-01
AR112457A1 (es) 2019-10-30
CN110914268A (zh) 2020-03-24
EP3661936A1 (en) 2020-06-10
JP2020529413A (ja) 2020-10-08
ES2904938T3 (es) 2022-04-06
US20200123154A1 (en) 2020-04-23
JP6850396B2 (ja) 2021-03-31
TWI670271B (zh) 2019-09-01
WO2019027783A1 (en) 2019-02-07

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