AR112457A1 - Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona - Google Patents
Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-onaInfo
- Publication number
- AR112457A1 AR112457A1 ARP180101984A AR112457A1 AR 112457 A1 AR112457 A1 AR 112457A1 AR P180101984 A ARP180101984 A AR P180101984A AR 112457 A1 AR112457 A1 AR 112457A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- pirazin
- triazolo
- derivatives
- cyclopropyl
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 229940121836 Phosphodiesterase 1 inhibitor Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762540122P | 2017-08-02 | 2017-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112457A1 true AR112457A1 (es) | 2019-10-30 |
Family
ID=63165529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101984 AR112457A1 (es) | 2017-08-02 | 2018-07-17 | Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11180503B2 (https=) |
| EP (1) | EP3661936B1 (https=) |
| JP (1) | JP6850396B2 (https=) |
| CN (1) | CN110914268B (https=) |
| AR (1) | AR112457A1 (https=) |
| ES (1) | ES2904938T3 (https=) |
| TW (1) | TWI670271B (https=) |
| WO (1) | WO2019027783A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11453673B2 (en) | 2018-02-06 | 2022-09-27 | Eli Lilly And Company | Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors |
| WO2025059641A1 (en) | 2023-09-14 | 2025-03-20 | Eli Lilly And Company | Pde1 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4354027A (en) | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
| MX2009000170A (es) * | 2006-06-23 | 2009-01-23 | Incyte Corp | Derivados de purinona como agonistas de hm74a. |
| US8299080B2 (en) | 2006-12-13 | 2012-10-30 | Aska Pharmaceutical Co., Ltd. | Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor |
| WO2008103357A1 (en) | 2007-02-21 | 2008-08-28 | E. I. Du Pont De Nemours And Company | Fungicidal tricyclic 1,2,4-triazoles |
| EP2509983B1 (en) * | 2009-11-16 | 2014-09-17 | Merck Sharp & Dohme Corp. | FUSED TRICYCLIC COMPOUNDS WITH ADENOSINE A2a RECEPTOR ANTAGONIST ACTIVITY |
| KR20130097178A (ko) | 2010-09-07 | 2013-09-02 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴녹살린 화합물 |
| CN103874701A (zh) * | 2011-09-09 | 2014-06-18 | H.隆德贝克有限公司 | 吡啶化合物和其用途 |
| CA2877146C (en) | 2012-06-18 | 2020-10-20 | Dart Neuroscience (Cayman) Ltd | Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds |
| US20140045856A1 (en) * | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| TW201629064A (zh) * | 2014-10-10 | 2016-08-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之三唑並吡酮 |
| TWI609870B (zh) * | 2016-02-12 | 2018-01-01 | 美國禮來大藥廠 | Pde1抑制劑 |
| JOP20170164A1 (ar) * | 2016-08-25 | 2019-01-30 | Lilly Co Eli | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري |
-
2018
- 2018-07-17 AR ARP180101984 patent/AR112457A1/es unknown
- 2018-07-19 TW TW107124931A patent/TWI670271B/zh not_active IP Right Cessation
- 2018-07-26 WO PCT/US2018/043845 patent/WO2019027783A1/en not_active Ceased
- 2018-07-26 US US16/624,545 patent/US11180503B2/en active Active
- 2018-07-26 JP JP2020505232A patent/JP6850396B2/ja active Active
- 2018-07-26 ES ES18752976T patent/ES2904938T3/es active Active
- 2018-07-26 CN CN201880050277.1A patent/CN110914268B/zh active Active
- 2018-07-26 EP EP18752976.3A patent/EP3661936B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3661936A1 (en) | 2020-06-10 |
| TW201920175A (zh) | 2019-06-01 |
| JP2020529413A (ja) | 2020-10-08 |
| JP6850396B2 (ja) | 2021-03-31 |
| EP3661936B1 (en) | 2021-12-22 |
| TWI670271B (zh) | 2019-09-01 |
| US20200123154A1 (en) | 2020-04-23 |
| WO2019027783A1 (en) | 2019-02-07 |
| ES2904938T3 (es) | 2022-04-06 |
| CN110914268B (zh) | 2022-04-19 |
| US11180503B2 (en) | 2021-11-23 |
| CN110914268A (zh) | 2020-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20221504A1 (es) | Derivados de un inhibidor de fgfr | |
| EA201991161A1 (ru) | 7-фенилэтиламино-4h-пиримидо[4,5-d][1,3]оксазин-2-оновые соединения в качестве ингибиторов мутантных idh1 и idh2 | |
| MX2021013640A (es) | Composiciones novedosas y metodos. | |
| ES2609857T3 (es) | 4-(8-metoxi-1-((1-metoxipropan-2-il)-2-(tetrahidro-2H-piran-4-il)-1H-imidazo[4,5-C]quinolin-7-il)-3,5-dimetilisoxazol y su uso como inhibidor de bromodominios | |
| MX2022000244A (es) | Pirrolo[2,3-b]pirazinas como inhibidores de hpk1 y uso de las mismas. | |
| MX2023009524A (es) | Formas solidas cristalinas de inhibidor de bromodominio y extra-terminal (bet). | |
| CL2018002803A1 (es) | Antagonistas de c5ar solubles | |
| ECSP13012764A (es) | COMPUESTO DE IMIDAZO[4,5-C]QUINOLIN-2-ONA Y SU USO COMO INHIBIDOR DUAL DE CINASA PI3/mTOR | |
| UY37703A (es) | Compuestos heteroarílicos bicíclicos 6-6 fusionados y su uso como inhibidores de lats | |
| MX2023011675A (es) | Beta-hidroxietilaminas heteroaril sustituidas para su uso en el tratamiento de hiperglucemia. | |
| PH12016502252A1 (en) | Addition salts of (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile | |
| WO2014152029A3 (en) | Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors | |
| MX2023000418A (es) | Fluorofenil beta-hidroxietilaminas y su uso en el tratamiento de la hiperglucemia. | |
| CL2017003032A1 (es) | Derivado de pirido[3,4-d]pirimidina y sal farmacéuticamente aceptable de éste | |
| MX376174B (es) | 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h)-onas como inhibidores de proteinas de bromodominio y extra terminal (bet). | |
| CO6571861A2 (es) | Derivado de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina y su uso como inhibidor de la integrasa del vih | |
| MX2020002814A (es) | 7-bencil-4-(2-metilbencil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pir ido[3,4-e]pirimidin-5(1h)-ona, sales de la misma y metodos de uso. | |
| PE20152033A1 (es) | Heterociclos bicicliclos como inhibidores de fgfr | |
| BR112019024300A2 (pt) | Ativadores de guanilato ciclase solúvel com modo duplo de ação e inibidores da fosfodiesterase e usos dos mesmos | |
| MX391724B (es) | Nuevos derivados de triazolo[4,5-d]pirimidina. | |
| CO2020006907A2 (es) | Péptidos antimicrobianos y métodos para usarlos | |
| PE20170936A1 (es) | Compuestos novedosos de imidazopiridazina y su uso | |
| MX2019013383A (es) | Agente terapeutico para la demencia que combina derivado de pirazoloquinolina y memantina. | |
| PE20170683A1 (es) | Triazolo[4,5-d]pirimidinas como agonistas del receptor canabinoide 2 | |
| UY37250A (es) | Derivados macrocíclicos de indol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |