TWI664181B - 做為ｐｄｅ２抑制劑之經取代的［１，２，４］三唑并［１，５－ａ］嘧啶－７－基化合物 - Google Patents

做為ｐｄｅ２抑制劑之經取代的［１，２，４］三唑并［１，５－ａ］嘧啶－７－基化合物 Download PDF

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TWI664181B
TWI664181B TW104113093A TW104113093A TWI664181B TW I664181 B TWI664181 B TW I664181B TW 104113093 A TW104113093 A TW 104113093A TW 104113093 A TW104113093 A TW 104113093A TW I664181 B TWI664181 B TW I664181B
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methyl
triazolo
pyrimidin
hexahydropyridine
carbonyl
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TW104113093A
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Chinese (zh)
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TW201625625A (zh
Inventor
詹姆士 布里頓布雀
James Breitenbucher
葛雷米 福利司東
Graeme Freestone
羅倫特 高梅茲
Laurent Gomez
羅伯特 雷牧斯
Robert Lemus
基夫 利
Kiev Ly
瑪格麗特 麥克卡瑞科
Margaret MCCARRICK
威廉 佛尼爾
William Vernier
特洛伊 維克斯
Troy Vickers
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開群島商達特神經科學（開曼）有限責任公司
Dart Neuroscience (Cayman) Ltd
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Publication of TW201625625A publication Critical patent/TW201625625A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW104113093A 2014-04-23 2015-04-23 做為ｐｄｅ２抑制劑之經取代的［１，２，４］三唑并［１，５－ａ］嘧啶－７－基化合物 TWI664181B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983387P 2014-04-23 2014-04-23
US61/983,387 2014-04-23

Publications (2)

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TW201625625A TW201625625A (zh) 2016-07-16
TWI664181B true TWI664181B (zh) 2019-07-01

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US (5) US9932345B2 (https=)
EP (2) EP3597649B8 (https=)
JP (1) JP6626449B2 (https=)
KR (1) KR102471058B1 (https=)
CN (2) CN106459062A (https=)
AU (2) AU2015249753B2 (https=)
BR (1) BR112016024713B1 (https=)
CA (1) CA2938294C (https=)
DK (2) DK3134413T3 (https=)
ES (2) ES2902806T3 (https=)
HR (1) HRP20212035T1 (https=)
HU (1) HUE057317T2 (https=)
IL (2) IL248292A (https=)
MA (1) MA50375A (https=)
MX (1) MX358004B (https=)
NZ (1) NZ725161A (https=)
PL (1) PL3597649T3 (https=)
PT (1) PT3597649T (https=)
RU (1) RU2659070C9 (https=)
SG (1) SG11201606216UA (https=)
SI (1) SI3597649T1 (https=)
TW (1) TWI664181B (https=)
WO (1) WO2015164508A1 (https=)

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CN109890824B (zh) * 2016-11-02 2022-05-24 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
EA039102B1 (ru) * 2016-11-02 2021-12-03 Янссен Фармацевтика Нв Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2
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TWI907472B (zh) 2020-08-05 2025-12-11 匈牙利商羅特格登公司 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物

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PT3597649T (pt) 2022-01-21
WO2015164508A4 (en) 2015-12-23
US20200095256A1 (en) 2020-03-26
RU2659070C2 (ru) 2018-06-28
EP3134413B1 (en) 2019-09-11
DK3597649T3 (da) 2022-01-10
HRP20212035T1 (hr) 2022-04-01
US20170057967A1 (en) 2017-03-02
AU2019283994B2 (en) 2021-05-27
BR112016024713A2 (pt) 2017-08-15
HUE057317T2 (hu) 2022-04-28
US10501465B2 (en) 2019-12-10
EP3134413A1 (en) 2017-03-01
MA50375A (fr) 2021-05-26
KR20160145745A (ko) 2016-12-20
PL3597649T3 (pl) 2022-04-04
MX358004B (es) 2018-07-31
TW201625625A (zh) 2016-07-16
RU2016143387A (ru) 2018-05-23
RU2016143387A3 (https=) 2018-05-23
EP3597649A1 (en) 2020-01-22
ES2902806T3 (es) 2022-03-29
US20230192698A1 (en) 2023-06-22
AU2019283994C1 (en) 2021-12-09
ES2759246T3 (es) 2020-05-08
SI3597649T1 (sl) 2022-04-29
EP3597649B8 (en) 2022-02-16
AU2019283994A1 (en) 2020-01-23
US11186582B2 (en) 2021-11-30
US9932345B2 (en) 2018-04-03
MX2016013860A (es) 2017-05-12
AU2015249753B2 (en) 2019-10-10
RU2659070C9 (ru) 2018-08-24
IL248292A (en) 2017-09-28
NZ725161A (en) 2017-10-27
JP6626449B2 (ja) 2019-12-25
EP3597649B1 (en) 2021-10-13
CN110092788A (zh) 2019-08-06
SG11201606216UA (en) 2016-09-29
DK3134413T3 (da) 2019-10-14
CA2938294C (en) 2023-02-21
CN110092788B (zh) 2022-02-25
AU2015249753A1 (en) 2016-11-03
US20250092047A1 (en) 2025-03-20
CN106459062A (zh) 2017-02-22
IL254224A0 (en) 2017-10-31
IL254224B (en) 2019-01-31
KR102471058B1 (ko) 2022-11-25
CA2938294A1 (en) 2015-10-29
BR112016024713B1 (pt) 2023-05-02
JP2017513808A (ja) 2017-06-01
US20180179216A1 (en) 2018-06-28
WO2015164508A1 (en) 2015-10-29

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