CA2938294C - Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors - Google Patents

Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors Download PDF

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Publication number
CA2938294C
CA2938294C CA2938294A CA2938294A CA2938294C CA 2938294 C CA2938294 C CA 2938294C CA 2938294 A CA2938294 A CA 2938294A CA 2938294 A CA2938294 A CA 2938294A CA 2938294 C CA2938294 C CA 2938294C
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methyl
pyrimidin
triazolo
piperidine
tri azolo
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English (en)
French (fr)
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CA2938294A1 (en
Inventor
James Breitenbucher
Graeme Freestone
Laurent Gomez
Robert Lemus
Kiev Ly
Margaret MCCARRICK
William Vernier
Troy Vickers
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Dart Neuroscience Cayman Ltd
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Dart Neuroscience Cayman Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2938294A 2014-04-23 2015-04-22 Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors Active CA2938294C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983387P 2014-04-23 2014-04-23
US61/983,387 2014-04-23
PCT/US2015/027102 WO2015164508A1 (en) 2014-04-23 2015-04-22 Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors

Publications (2)

Publication Number Publication Date
CA2938294A1 CA2938294A1 (en) 2015-10-29
CA2938294C true CA2938294C (en) 2023-02-21

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CA2938294A Active CA2938294C (en) 2014-04-23 2015-04-22 Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors

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US (5) US9932345B2 (https=)
EP (2) EP3597649B8 (https=)
JP (1) JP6626449B2 (https=)
KR (1) KR102471058B1 (https=)
CN (2) CN106459062A (https=)
AU (2) AU2015249753B2 (https=)
BR (1) BR112016024713B1 (https=)
CA (1) CA2938294C (https=)
DK (2) DK3134413T3 (https=)
ES (2) ES2902806T3 (https=)
HR (1) HRP20212035T1 (https=)
HU (1) HUE057317T2 (https=)
IL (2) IL248292A (https=)
MA (1) MA50375A (https=)
MX (1) MX358004B (https=)
NZ (1) NZ725161A (https=)
PL (1) PL3597649T3 (https=)
PT (1) PT3597649T (https=)
RU (1) RU2659070C9 (https=)
SG (1) SG11201606216UA (https=)
SI (1) SI3597649T1 (https=)
TW (1) TWI664181B (https=)
WO (1) WO2015164508A1 (https=)

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DK3134413T3 (da) 2014-04-23 2019-10-14 Dart Neuroscience Cayman Ltd Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer
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CN108349979B (zh) * 2015-11-02 2021-04-09 詹森药业有限公司 [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物
AU2017222964B2 (en) 2016-02-25 2020-01-02 Asceneuron S. A. Glycosidase inhibitors
KR20180132629A (ko) 2016-02-25 2018-12-12 아셰뉴론 에스아 글리코시다제 저해제
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
CA3014572C (en) 2016-02-25 2023-10-03 Asceneuron S.A. Acid addition salts of piperazine derivatives
CN109890824B (zh) * 2016-11-02 2022-05-24 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
EA039102B1 (ru) * 2016-11-02 2021-12-03 Янссен Фармацевтика Нв Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2
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PT3597649T (pt) 2022-01-21
WO2015164508A4 (en) 2015-12-23
US20200095256A1 (en) 2020-03-26
RU2659070C2 (ru) 2018-06-28
EP3134413B1 (en) 2019-09-11
DK3597649T3 (da) 2022-01-10
HRP20212035T1 (hr) 2022-04-01
US20170057967A1 (en) 2017-03-02
AU2019283994B2 (en) 2021-05-27
BR112016024713A2 (pt) 2017-08-15
HUE057317T2 (hu) 2022-04-28
US10501465B2 (en) 2019-12-10
EP3134413A1 (en) 2017-03-01
MA50375A (fr) 2021-05-26
KR20160145745A (ko) 2016-12-20
PL3597649T3 (pl) 2022-04-04
MX358004B (es) 2018-07-31
TW201625625A (zh) 2016-07-16
RU2016143387A (ru) 2018-05-23
RU2016143387A3 (https=) 2018-05-23
EP3597649A1 (en) 2020-01-22
ES2902806T3 (es) 2022-03-29
US20230192698A1 (en) 2023-06-22
AU2019283994C1 (en) 2021-12-09
ES2759246T3 (es) 2020-05-08
SI3597649T1 (sl) 2022-04-29
EP3597649B8 (en) 2022-02-16
AU2019283994A1 (en) 2020-01-23
US11186582B2 (en) 2021-11-30
US9932345B2 (en) 2018-04-03
MX2016013860A (es) 2017-05-12
AU2015249753B2 (en) 2019-10-10
RU2659070C9 (ru) 2018-08-24
IL248292A (en) 2017-09-28
NZ725161A (en) 2017-10-27
JP6626449B2 (ja) 2019-12-25
EP3597649B1 (en) 2021-10-13
CN110092788A (zh) 2019-08-06
SG11201606216UA (en) 2016-09-29
DK3134413T3 (da) 2019-10-14
TWI664181B (zh) 2019-07-01
CN110092788B (zh) 2022-02-25
AU2015249753A1 (en) 2016-11-03
US20250092047A1 (en) 2025-03-20
CN106459062A (zh) 2017-02-22
IL254224A0 (en) 2017-10-31
IL254224B (en) 2019-01-31
KR102471058B1 (ko) 2022-11-25
CA2938294A1 (en) 2015-10-29
BR112016024713B1 (pt) 2023-05-02
JP2017513808A (ja) 2017-06-01
US20180179216A1 (en) 2018-06-28
WO2015164508A1 (en) 2015-10-29

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