TWI631140B - 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途 - Google Patents

可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途 Download PDF

Info

Publication number
TWI631140B
TWI631140B TW102116466A TW102116466A TWI631140B TW I631140 B TWI631140 B TW I631140B TW 102116466 A TW102116466 A TW 102116466A TW 102116466 A TW102116466 A TW 102116466A TW I631140 B TWI631140 B TW I631140B
Authority
TW
Taiwan
Prior art keywords
antibody
homo sapiens
seq
dna
antibodies
Prior art date
Application number
TW102116466A
Other languages
English (en)
Chinese (zh)
Other versions
TW201400504A (zh
Inventor
安德莉亞斯 衛爾曼
朱麗亞 施特臘斯堡格
弗蘭克 迪特默
邁克爾 施特雷拉特
安佳 布赫米勒
喬安娜 古魯辛斯卡格貝爾
莉卡達 芬納恩
瑪蒂娜 謝弗爾
克里斯多夫 傑茲
漢娜 喬莉森
板倉亞沙子
梁蘊慧
艾瑞克 塔克
Original Assignee
德商拜耳製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 德商拜耳製藥股份有限公司 filed Critical 德商拜耳製藥股份有限公司
Publication of TW201400504A publication Critical patent/TW201400504A/zh
Application granted granted Critical
Publication of TWI631140B publication Critical patent/TWI631140B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW102116466A 2012-05-10 2013-05-09 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途 TWI631140B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
??12167438.6 2012-05-10
EP12167438 2012-05-10
??12181697.9 2012-08-24
EP12181697 2012-08-24
EP13150361 2013-01-07
??13150361.7 2013-01-07
US201361817675P 2013-04-30 2013-04-30
US61/817,675 2013-04-30

Publications (2)

Publication Number Publication Date
TW201400504A TW201400504A (zh) 2014-01-01
TWI631140B true TWI631140B (zh) 2018-08-01

Family

ID=49550177

Family Applications (2)

Application Number Title Priority Date Filing Date
TW106143305A TWI644925B (zh) 2012-05-10 2013-05-09 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途
TW102116466A TWI631140B (zh) 2012-05-10 2013-05-09 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW106143305A TWI644925B (zh) 2012-05-10 2013-05-09 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途

Country Status (24)

Country Link
US (4) US9783614B2 (enExample)
EP (2) EP3404045A1 (enExample)
JP (2) JP6348900B2 (enExample)
KR (1) KR102060376B1 (enExample)
CN (1) CN104684932B (enExample)
AR (1) AR091024A1 (enExample)
AU (2) AU2013258043B2 (enExample)
BR (1) BR112014027952B1 (enExample)
CA (1) CA2872926C (enExample)
DK (1) DK2847228T3 (enExample)
ES (1) ES2698950T3 (enExample)
HR (1) HRP20181680T1 (enExample)
HU (1) HUE040580T2 (enExample)
IL (1) IL235238B (enExample)
LT (1) LT2847228T (enExample)
MX (1) MX362454B (enExample)
NZ (1) NZ701121A (enExample)
PL (1) PL2847228T3 (enExample)
RS (1) RS57889B1 (enExample)
SG (2) SG10201609322QA (enExample)
SI (1) SI2847228T1 (enExample)
TW (2) TWI644925B (enExample)
WO (1) WO2013167669A1 (enExample)
ZA (1) ZA201407784B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3002298B1 (en) 2007-11-21 2019-08-28 Oregon Health & Science University Anti-factor xi monoclonal antibodies and methods of use thereof
ES2720594T3 (es) 2008-12-18 2019-07-23 Univ Oregon Health & Science Anticuerpos anti-fXI y métodos de uso
EP2766347B1 (en) 2011-10-14 2016-05-04 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP3309148A1 (en) 2011-10-14 2018-04-18 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP2899183B1 (en) 2011-10-14 2018-09-19 Bristol-Myers Squibb Company Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors
SG10201609322QA (en) 2012-05-10 2017-01-27 Bayer Pharma AG Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof
WO2014059202A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
DK2906551T3 (en) 2012-10-12 2018-05-22 Bristol Myers Squibb Co CRYSTALLIC FORMS OF A FACTOR XIA INHIBITOR
EP2906541B1 (en) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9738655B2 (en) 2013-03-25 2017-08-22 Bristol-Myers Squibb Company Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
NO2760821T3 (enExample) 2014-01-31 2018-03-10
UY40230A (es) 2014-01-31 2023-08-15 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Macrociclos con grupos P2’ heterocíclicos como inhibidores del factor XIa y composiciones farmacéuticas que los comprenden
TN2017000019A1 (en) 2014-08-07 2018-07-04 Novartis Ag Angiopoietin-like 4 antibodies and methods of use.
TW201613977A (en) 2014-08-07 2016-04-16 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
ES2714283T3 (es) 2014-09-04 2019-05-28 Bristol Myers Squibb Co Macrociclos de diamida que son inhibidores de FXIa
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
AU2015373910B2 (en) 2015-01-02 2021-11-18 Takeda Pharmaceutical Company Limited Bispecific antibodies against plasma kallikrein and factor XII
JOP20200312A1 (ar) * 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
US10913802B2 (en) 2015-07-21 2021-02-09 Dyax Corp. Monoclonal antibody inhibitor of factor XIIA
WO2017015619A1 (en) 2015-07-23 2017-01-26 The Regents Of The University Of California Antibodies to coagulation factor xia and uses thereof
CA3010224A1 (en) 2016-01-22 2017-07-27 Merck Sharp & Dohme Corp. Anti-coagulation factor xi antibodies
EP3433279A1 (en) 2016-03-23 2019-01-30 Prothix BV Monoclonal antibodies against the active site of factor xi and uses thereof
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
EA201892716A1 (ru) 2016-06-14 2019-05-31 Мерк Шарп И Доум Корп. Антитела к фактору свертывания xi
AU2017329645A1 (en) 2016-09-20 2019-04-04 Aronora Inc. Novel antibodies against factor XI and uses thereof
US20200054719A1 (en) * 2016-11-02 2020-02-20 Erik Ian Tucker E-we thrombin analog and fibrinolytic combination
JP7139332B2 (ja) * 2016-12-23 2022-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法
IL316673A (en) * 2016-12-23 2024-12-01 Novartis Ag Factor XI/XIA FOR USE IN PREVENTING, TREATING, MANAGING OR REDUCING THE RISK OF STROKE OR THROMBOEMBOLISM IN A SUBJECT AFFLICTED WITH END STAGE RENAL DISEASE
RS62780B1 (sr) * 2017-01-19 2022-01-31 Bayer Pharma AG Nova stabilna formulacija za fxia antitela
US11958911B2 (en) 2017-02-10 2024-04-16 Shanghai Benemae Pharmaceutical Anti-coagulation factor XI antibody
CN108409863B (zh) * 2017-02-10 2023-09-26 上海仁会生物制药股份有限公司 抗凝血因子xi抗体
AU2018372135A1 (en) 2017-11-22 2020-05-28 Novartis Ag Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof
PE20210462A1 (es) 2018-07-05 2021-03-08 Bayer Ag METODO PARA LA PRODUCCION DE GRANULOS LIOFILIZADOS QUE COMPRENDEN UN ANTICUERPO ANTI-FACTOR XIa (FXIa) DE LA COAGULACION
MA53322A (fr) * 2018-08-01 2021-11-10 Novo Nordisk As Anticorps procoagulants améliorés
CN112514286B (zh) 2018-08-07 2025-05-13 日本电信电话株式会社 光传输系统和传输模式选择方法
BR112021002472A2 (pt) * 2018-08-09 2021-07-27 Shanghai Benemae Pharmaceutical Corporation anticorpos antifator xi
EP3852820B1 (en) * 2018-09-17 2024-11-20 Board of Regents, The University of Texas System Compositions and methods for treating bone injury
CA3117856A1 (en) 2018-10-31 2020-05-07 Bayer Aktiengesellschaft Reversal agents for neutralizing the therapeutic activity of anti-fxia antibodies
KR20210118853A (ko) 2019-01-21 2021-10-01 아로노라 인크. 항혈전과 항염 효과를 갖는 인자 xi에 대한 신규 인간화 항체 및 그 용도
CN117186232B (zh) 2019-04-16 2024-07-30 四川科伦博泰生物医药股份有限公司 抗FXI/FXIa抗体及其用途
CN110423278B (zh) 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
CN114269790B (zh) * 2020-07-02 2023-11-24 北京拓界生物医药科技有限公司 抗FXI/FXIa抗体、其抗原结合片段及医药用途
WO2024141099A1 (zh) * 2022-12-30 2024-07-04 甘李药业股份有限公司 抗凝血因子XI和/或其活化形式因子XIa的抗体及其用途
CN119454938B (zh) * 2024-11-15 2025-07-25 广州骐骥生物科技有限公司 一种枸橼酸透析浓缩液及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067660A2 (en) * 2007-11-21 2009-05-28 Oregon Health & Science University Anti-factor xi monoclonal antibodies and methods of use thereof

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5877289A (en) 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
DE4319041A1 (de) 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
ES2176484T3 (es) 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
US20030235587A1 (en) 1998-08-07 2003-12-25 Feuerstein Giora Z. Anticoagulant agents useful in treatment of thrombosis
DE19642255A1 (de) 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
EP0934311B1 (de) 1996-10-14 2009-05-13 Bayer HealthCare AG Neue heterocyclylmethyl-substituierte pyrazolderivate und ihre verwendung in der behandlung von herz-kreislauf-erkrankungen
DE19649460A1 (de) 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
GB9701425D0 (en) 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834045A1 (de) 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
WO2000007626A1 (en) 1998-08-07 2000-02-17 Smithkline Beecham Corporation Use of anti-coagulation factor antibodies as long-lasting protective agents
DE19846514A1 (de) 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
DE19920352A1 (de) 1999-05-04 2000-11-09 Bayer Ag Substituiertes Pyrazolderivat
DE19942809A1 (de) 1999-09-08 2001-03-15 Bayer Ag Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
WO2003013423A2 (en) 2001-08-05 2003-02-20 Gvg, Inc. Antithrombotic agent
US7270976B2 (en) 2004-07-19 2007-09-18 American Diagnostica, Inc. Methods for measuring ADAMTS13 activity and protein on platelets and in plasma
US20080138837A1 (en) 2004-07-19 2008-06-12 Robert Greenfield Methods and kits for detecting and measuring ADAMTS13/FXI complexes
US7279513B2 (en) 2004-11-19 2007-10-09 Nalco Company Preparation of neutralized ethylene-acrylic acid polymer dispersions and use in printing media for improvement of digital toner adhesion
DE102005050376A1 (de) 2005-10-21 2007-05-31 Bayer Healthcare Ag Dicarbonsäure-Derivate und ihre Verwendung
DE102005050498A1 (de) 2005-10-21 2007-06-06 Bayer Healthcare Aktiengesellschaft Cyclopropylessigsäure-Derivate und ihre Verwendung
DE102005050375A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Tetrazol-Derivate und ihre Verwendung
DE102005050497A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Difluorphenol-Derivate und ihre Verwendung
DE102005050377A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclische Verbindungen und ihre Verwendung
EA201201533A1 (ru) 2006-08-18 2014-11-28 Новартис Аг Prlr-специфическое антитело и его применения
CA2685015A1 (en) 2007-04-23 2008-11-06 Schering Corporation Anti-mdl-1 antibodies
WO2009046274A1 (en) 2007-10-03 2009-04-09 The University Of Vermont And State Agriculture College Methods of detection of factor xia and tissue factor
DK2297207T3 (en) * 2008-06-19 2018-12-03 Prothix Bv USING ANTI-FACTOR XI ANTIBODIES FOR PREVENTION OR TREATMENT OF THROME CREATION
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
ES2720594T3 (es) * 2008-12-18 2019-07-23 Univ Oregon Health & Science Anticuerpos anti-fXI y métodos de uso
JP2013516389A (ja) 2009-01-06 2013-05-13 ダイアックス コーポレーション カリクレイン阻害剤による粘膜炎治療
EA023254B1 (ru) 2010-05-27 2016-05-31 Мерк Шарп Энд Домэ Корп. Активаторы растворимой гуанилатциклазы
EP2585055A1 (de) 2010-06-25 2013-05-01 Bayer Intellectual Property GmbH Verwendung von stimulatoren und aktivatoren der löslichen guanylatzyklase zur behandlung von sichelzellanämie und konservierung von blutersatzstoffen
JP6114189B2 (ja) 2010-07-09 2017-04-12 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 縮合ピリミジンおよびトリアジンならびに心血管障害の処置および／または予防のためのその使用
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
WO2012152629A1 (de) 2011-05-06 2012-11-15 Bayer Intellectual Property Gmbh Substituierte imidazopyridine und imidazopyridazine und ihre verwendung
US9090610B2 (en) 2011-04-21 2015-07-28 Bayer Intellectual Property Gmbh Fluoroalkyl-substituted pyrazolopyridines and use thereof
JP6096778B2 (ja) 2011-09-01 2017-03-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピロロピラジンキナーゼ阻害剤
EA026701B1 (ru) 2011-09-02 2017-05-31 Байер Интеллектуэль Проперти Гмбх Замещенные аннелированные пиримидины, способ их получения, их применение и лекарственное средство для лечения и/или профилактики заболеваний
SG10201609322QA (en) * 2012-05-10 2017-01-27 Bayer Pharma AG Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009067660A2 (en) * 2007-11-21 2009-05-28 Oregon Health & Science University Anti-factor xi monoclonal antibodies and methods of use thereof

Also Published As

Publication number Publication date
IL235238B (en) 2019-08-29
KR102060376B1 (ko) 2019-12-30
ZA201407784B (en) 2019-01-30
CN104684932A (zh) 2015-06-03
US9783614B2 (en) 2017-10-10
SG11201406719UA (en) 2014-11-27
US10221247B2 (en) 2019-03-05
HUE040580T2 (hu) 2019-03-28
EP2847228A1 (en) 2015-03-18
DK2847228T3 (en) 2018-11-19
JP2015517305A (ja) 2015-06-22
MX2014013568A (es) 2014-12-08
JP2018148920A (ja) 2018-09-27
CN104684932B (zh) 2019-03-12
KR20150008166A (ko) 2015-01-21
ES2698950T3 (es) 2019-02-06
LT2847228T (lt) 2018-11-12
US20180112009A1 (en) 2018-04-26
HRP20181680T1 (hr) 2018-12-14
SI2847228T1 (sl) 2018-11-30
CA2872926C (en) 2022-07-05
US11046783B2 (en) 2021-06-29
JP6348900B2 (ja) 2018-06-27
AU2018200850C1 (en) 2020-03-12
HK1207091A1 (en) 2016-01-22
US20180051093A1 (en) 2018-02-22
IL235238A0 (en) 2014-12-31
WO2013167669A1 (en) 2013-11-14
MX362454B (es) 2019-01-18
TW201811834A (zh) 2018-04-01
AU2013258043B2 (en) 2017-11-30
EP2847228B1 (en) 2018-07-25
TWI644925B (zh) 2018-12-21
US10040866B2 (en) 2018-08-07
US20190284300A1 (en) 2019-09-19
US20150099298A1 (en) 2015-04-09
CA2872926A1 (en) 2013-11-14
AU2018200850A1 (en) 2018-02-22
BR112014027952A2 (pt) 2019-07-09
SG10201609322QA (en) 2017-01-27
RS57889B1 (sr) 2019-01-31
AU2013258043A1 (en) 2014-11-13
AU2018200850B2 (en) 2019-09-19
NZ701121A (en) 2017-06-30
TW201400504A (zh) 2014-01-01
BR112014027952B1 (pt) 2022-06-21
PL2847228T3 (pl) 2019-03-29
AR091024A1 (es) 2014-12-30
EP3404045A1 (en) 2018-11-21

Similar Documents

Publication Publication Date Title
TWI631140B (zh) 可結合至凝血因子ＸＩ及／或其活化型式因子ＸＩａ的抗體及其用途
CN114316061B (zh) 针对血浆激肽释放酶和因子xii的双特异性抗体
US10266607B2 (en) Antibody binding to TFPI and composition comprising the same
CN101932606A (zh) 对冯维勒布兰德氏因子特异的人源化抗体
RU2758160C2 (ru) Новые антитела против фактора xi и их применения
JP2022523007A (ja) 抗血栓症作用および抗炎症作用を有する、第ｘｉ因子に対する新規ヒト化抗体およびその使用
HK1207091B (zh) 能够结合凝血因子xi和/或其活化形式因子xia的抗体及其用途
TR201815476T4 (tr) Koagülasyon Faktörü XI ve/veya bunun aktive formu faktör XIa'ya bağlanabilen antikorlar ve bunların kullanımları.

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees