ZA201407784B - Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof - Google Patents
Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereofInfo
- Publication number
- ZA201407784B ZA201407784B ZA2014/07784A ZA201407784A ZA201407784B ZA 201407784 B ZA201407784 B ZA 201407784B ZA 2014/07784 A ZA2014/07784 A ZA 2014/07784A ZA 201407784 A ZA201407784 A ZA 201407784A ZA 201407784 B ZA201407784 B ZA 201407784B
- Authority
- ZA
- South Africa
- Prior art keywords
- binding
- antibodies capable
- activated form
- form factor
- xia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167438 | 2012-05-10 | ||
| EP12181697 | 2012-08-24 | ||
| EP13150361 | 2013-01-07 | ||
| US201361817675P | 2013-04-30 | 2013-04-30 | |
| PCT/EP2013/059618 WO2013167669A1 (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201407784B true ZA201407784B (en) | 2019-01-30 |
Family
ID=49550177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/07784A ZA201407784B (en) | 2012-05-10 | 2014-10-24 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9783614B2 (enExample) |
| EP (2) | EP2847228B1 (enExample) |
| JP (2) | JP6348900B2 (enExample) |
| KR (1) | KR102060376B1 (enExample) |
| CN (1) | CN104684932B (enExample) |
| AR (1) | AR091024A1 (enExample) |
| AU (2) | AU2013258043B2 (enExample) |
| BR (1) | BR112014027952B1 (enExample) |
| CA (1) | CA2872926C (enExample) |
| DK (1) | DK2847228T3 (enExample) |
| ES (1) | ES2698950T3 (enExample) |
| HR (1) | HRP20181680T1 (enExample) |
| HU (1) | HUE040580T2 (enExample) |
| IL (1) | IL235238B (enExample) |
| LT (1) | LT2847228T (enExample) |
| MX (1) | MX362454B (enExample) |
| NZ (1) | NZ701121A (enExample) |
| PL (1) | PL2847228T3 (enExample) |
| RS (1) | RS57889B1 (enExample) |
| SG (2) | SG10201609322QA (enExample) |
| SI (1) | SI2847228T1 (enExample) |
| TW (2) | TWI631140B (enExample) |
| WO (1) | WO2013167669A1 (enExample) |
| ZA (1) | ZA201407784B (enExample) |
Families Citing this family (47)
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| CA2705851C (en) | 2007-11-21 | 2016-11-01 | Oregon Health & Science University | Anti-factor xi monoclonal antibodies and methods of use thereof |
| AU2009335643B2 (en) | 2008-12-18 | 2014-05-29 | Oregon Health & Science University | Anti-fXI antibodies and methods of use |
| IN2014CN02805A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| IN2014CN02806A (enExample) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| LT2766346T (lt) | 2011-10-14 | 2017-06-12 | Bristol-Myers Squibb Company | Pakeistieji tetrahidroizochinolino junginiai, kaip faktoriaus xia inhibitoriai |
| US9783614B2 (en) | 2012-05-10 | 2017-10-10 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor Xia and uses thereof |
| HRP20180465T1 (hr) | 2012-10-12 | 2018-05-04 | Bristol-Myers Squibb Company | Kristalni oblici inhibitora faktora xia |
| US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
| NO2760821T3 (enExample) | 2014-01-31 | 2018-03-10 | ||
| JP6505727B2 (ja) | 2014-01-31 | 2019-04-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロ環式ｐ２’基を有する第ｘｉａ因子阻害剤としてのマクロ環 |
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| EA201790336A1 (ru) | 2014-08-07 | 2017-06-30 | Новартис Аг | Антитела к ангиопоэтинподобному белку 4 и способы применения |
| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
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| CA2972800A1 (en) | 2015-01-02 | 2016-07-07 | Dyax Corp. | Bispecific antibodies against plasma kallikrein and factor xii |
| JOP20160131B1 (ar) * | 2015-06-26 | 2022-03-14 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| EP3325516B1 (en) | 2015-07-21 | 2021-12-15 | Takeda Pharmaceutical Company Limited | A monoclonal antibody inhibitor of factor xiia |
| US11066481B2 (en) | 2015-07-23 | 2021-07-20 | The Regents Of The University Of California | Antibodies to coagulation factor XIa and uses thereof |
| US10053515B2 (en) | 2016-01-22 | 2018-08-21 | Merck Sharp & Dohme Corp. | Anti-coagulation factor XI antibodies |
| KR102448456B1 (ko) * | 2016-03-23 | 2022-09-28 | 프로틱스 비브이 | 인자 xi의 활성 부위에 대한 모노클로날 항체 및 이의 용도 |
| JP7103950B2 (ja) | 2016-04-22 | 2022-07-20 | アクセレロン ファーマ インコーポレーテッド | Ａｌｋ７結合性タンパク質及びその使用 |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| EA201892716A1 (ru) | 2016-06-14 | 2019-05-31 | Мерк Шарп И Доум Корп. | Антитела к фактору свертывания xi |
| AU2017329645A1 (en) * | 2016-09-20 | 2019-04-04 | Aronora Inc. | Novel antibodies against factor XI and uses thereof |
| WO2018089248A2 (en) * | 2016-11-02 | 2018-05-17 | Tucker Erik L | E-we thrombin analog and fibrinolytic combination |
| CN118320078A (zh) * | 2016-12-23 | 2024-07-12 | 诺华股份有限公司 | 采用抗因子XI/XIa抗体治疗的方法 |
| KR102616666B1 (ko) * | 2016-12-23 | 2023-12-27 | 노파르티스 아게 | 인자 xi 항체 및 사용 방법 |
| PT3570882T (pt) * | 2017-01-19 | 2022-01-11 | Bayer Pharma AG | Nova formulação estável para anticorpos fxia |
| US11958911B2 (en) | 2017-02-10 | 2024-04-16 | Shanghai Benemae Pharmaceutical | Anti-coagulation factor XI antibody |
| CN108409863B (zh) * | 2017-02-10 | 2023-09-26 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| EP3713965A1 (en) | 2017-11-22 | 2020-09-30 | Novartis AG | Reversal binding agents for anti-factor xi/xia antibodies and uses thereof |
| WO2020008022A1 (en) * | 2018-07-05 | 2020-01-09 | Bayer Aktiengesellschaft | METHOD FOR THE PRODUCTION OF FREEZE-DRIED PELLETS COMPRISING AN ANTI-COAGULATION FACTOR XIa (FXIa) ANTIBODY |
| PE20211399A1 (es) * | 2018-08-01 | 2021-07-27 | Novo Nordisk As | Anticuerpos procoagulantes mejorados |
| JP7152682B2 (ja) | 2018-08-07 | 2022-10-13 | 日本電信電話株式会社 | 光伝送システム及び伝送モード選択方法 |
| CN113227150B (zh) * | 2018-08-09 | 2023-07-28 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| EP3852820B1 (en) * | 2018-09-17 | 2024-11-20 | Board of Regents, The University of Texas System | Compositions and methods for treating bone injury |
| WO2020089380A1 (en) | 2018-10-31 | 2020-05-07 | Bayer Aktiengesellschaft | REVERSAL AGENTS FOR NEUTRALIZING THE THERAPEUTIC ACTIVITY OF ANTI-FXIa ANTIBODIES |
| US12703762B2 (en) | 2018-12-18 | 2026-08-11 | Novartis Ag | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| AU2020211905A1 (en) | 2019-01-21 | 2021-08-05 | Aronora Inc. | Novel humanized antibodies against factor XI having anti-thrombotic and anti-inflammatory effects and uses thereof |
| EP3957652A4 (en) | 2019-04-16 | 2023-06-21 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Anti-fxi/fxia antibody and use thereof |
| CN110423278B (zh) | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| BR112022026533A2 (pt) * | 2020-07-02 | 2023-01-17 | Beijing Tuo Jie Biopharmaceutical Co Ltd | Anticorpo anti-fxi/fxia, fragmento de ligação do mesmo, e antígenos e uso farmacêutico do mesmo |
| EP4644426A1 (en) * | 2022-12-30 | 2025-11-05 | Gan & Lee Pharmaceuticals Co., Ltd. | Antibody against coagulation factor xi and/or activated form factor xia thereof, and use thereof |
| CN119454938B (zh) * | 2024-11-15 | 2025-07-25 | 广州骐骥生物科技有限公司 | 一种枸橼酸透析浓缩液及其制备方法 |
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| WO2013030138A1 (en) | 2011-09-01 | 2013-03-07 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| BR112014005110A2 (pt) | 2011-09-02 | 2017-04-18 | Bayer Ip Gmbh | pirimidinas aneladas substituídas e utilização das mesmas |
| US9783614B2 (en) * | 2012-05-10 | 2017-10-10 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor Xia and uses thereof |
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