ZA201407784B - Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof - Google Patents
Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereofInfo
- Publication number
- ZA201407784B ZA201407784B ZA2014/07784A ZA201407784A ZA201407784B ZA 201407784 B ZA201407784 B ZA 201407784B ZA 2014/07784 A ZA2014/07784 A ZA 2014/07784A ZA 201407784 A ZA201407784 A ZA 201407784A ZA 201407784 B ZA201407784 B ZA 201407784B
- Authority
- ZA
- South Africa
- Prior art keywords
- binding
- antibodies capable
- activated form
- form factor
- xia
- Prior art date
Links
- 102100030563 Coagulation factor XI Human genes 0.000 title 1
- 108010074864 Factor XI Proteins 0.000 title 1
- 108010080805 Factor XIa Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167438 | 2012-05-10 | ||
| EP12181697 | 2012-08-24 | ||
| EP13150361 | 2013-01-07 | ||
| US201361817675P | 2013-04-30 | 2013-04-30 | |
| PCT/EP2013/059618 WO2013167669A1 (en) | 2012-05-10 | 2013-05-08 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201407784B true ZA201407784B (en) | 2019-01-30 |
Family
ID=49550177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/07784A ZA201407784B (en) | 2012-05-10 | 2014-10-24 | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9783614B2 (enExample) |
| EP (2) | EP2847228B1 (enExample) |
| JP (2) | JP6348900B2 (enExample) |
| KR (1) | KR102060376B1 (enExample) |
| CN (1) | CN104684932B (enExample) |
| AR (1) | AR091024A1 (enExample) |
| AU (2) | AU2013258043B2 (enExample) |
| BR (1) | BR112014027952B1 (enExample) |
| CA (1) | CA2872926C (enExample) |
| DK (1) | DK2847228T3 (enExample) |
| ES (1) | ES2698950T3 (enExample) |
| HR (1) | HRP20181680T1 (enExample) |
| HU (1) | HUE040580T2 (enExample) |
| IL (1) | IL235238B (enExample) |
| LT (1) | LT2847228T (enExample) |
| MX (1) | MX362454B (enExample) |
| NZ (1) | NZ701121A (enExample) |
| PL (1) | PL2847228T3 (enExample) |
| RS (1) | RS57889B1 (enExample) |
| SG (2) | SG11201406719UA (enExample) |
| SI (1) | SI2847228T1 (enExample) |
| TW (2) | TWI644925B (enExample) |
| WO (1) | WO2013167669A1 (enExample) |
| ZA (1) | ZA201407784B (enExample) |
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| AU2008326348B2 (en) | 2007-11-21 | 2014-01-30 | Oregon Health & Science University | Anti-factor XI monoclonal antibodies and methods of use thereof |
| AU2009335643B2 (en) | 2008-12-18 | 2014-05-29 | Oregon Health & Science University | Anti-fXI antibodies and methods of use |
| WO2013056034A1 (en) | 2011-10-14 | 2013-04-18 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| HRP20170784T8 (hr) | 2011-10-14 | 2018-05-18 | Bristol-Myers Squibb Company | Supstituirani spojevi tetrahidroizohinolina kao inhbitori xia faktora |
| EP2899183B1 (en) | 2011-10-14 | 2018-09-19 | Bristol-Myers Squibb Company | Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors |
| SI2847228T1 (sl) | 2012-05-10 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Protitelesa zmožna vezave na faktor koagulacije XI in/ali njeno aktivirano obliko faktor XIa in njihove uporabe |
| HRP20180465T1 (hr) | 2012-10-12 | 2018-05-04 | Bristol-Myers Squibb Company | Kristalni oblici inhibitora faktora xia |
| EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9315519B2 (en) | 2012-10-12 | 2016-04-19 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
| JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
| UY35971A (es) | 2014-01-31 | 2015-07-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Macrociclos con grupos p2? aromáticos como inhibidores del factor xia |
| NO2760821T3 (enExample) | 2014-01-31 | 2018-03-10 | ||
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| SG10201805646WA (en) | 2014-08-07 | 2018-08-30 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| EP3240570B1 (en) | 2015-01-02 | 2025-09-24 | Takeda Pharmaceutical Company Limited | Bispecific antibodies against plasma kallikrein and factor xii |
| JOP20200312A1 (ar) * | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| EA201890340A1 (ru) | 2015-07-21 | 2018-09-28 | Дайэкс Корп. | Моноклональное антитело-ингибитор фактора xiia |
| EP3325010B1 (en) | 2015-07-23 | 2023-06-21 | The Regents of The University of California | Antibodies to coagulation factor xia and uses thereof |
| AR107505A1 (es) * | 2016-01-22 | 2018-05-09 | Merck Sharp & Dohme | Anticuerpos anti-factor de la coagulación xi |
| US11059905B2 (en) | 2016-03-23 | 2021-07-13 | Prothix B.V. | Monoclonal antibodies against the active site of factor XI and uses thereof |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| KR102218714B1 (ko) | 2016-06-14 | 2021-02-24 | 머크 샤프 앤드 돔 코포레이션 | 항응고 인자 xi 항체 |
| DK3515947T3 (da) * | 2016-09-20 | 2024-07-29 | Aronora Inc | Hidtil ukendte antistoffer mod faktor XI og anvendelser deraf |
| EP3535390A4 (en) * | 2016-11-02 | 2020-11-25 | Inc. Aronora | COMBINATION OF THROMBIN E-WE ANALOGUE AND FIBRINOLYTIC |
| AU2017383232B2 (en) * | 2016-12-23 | 2024-09-12 | Novartis Ag | Factor XI antibodies and methods of use |
| US20200231701A1 (en) * | 2016-12-23 | 2020-07-23 | Novartis Ag | Methods of treatment with anti-factor xi/xia antibodies |
| BR112019014785A2 (pt) * | 2017-01-19 | 2020-05-12 | Bayer Pharma Aktiengesellschaft | Nova formulação estável para anticorpos fxia |
| WO2020029179A1 (en) * | 2018-08-09 | 2020-02-13 | Shanghai Benemae Pharmaceutical Corporation | Anti-factor xi antibodies |
| US11958911B2 (en) | 2017-02-10 | 2024-04-16 | Shanghai Benemae Pharmaceutical | Anti-coagulation factor XI antibody |
| CN108409863B (zh) * | 2017-02-10 | 2023-09-26 | 上海仁会生物制药股份有限公司 | 抗凝血因子xi抗体 |
| WO2019102353A1 (en) | 2017-11-22 | 2019-05-31 | Novartis Ag | Reversal binding agents for anti-factor xi/xia antibodies and uses thereof |
| JP2021529800A (ja) * | 2018-07-05 | 2021-11-04 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ＦＸＩａ抗体のための新規な安定した高濃度製剤 |
| PE20211399A1 (es) * | 2018-08-01 | 2021-07-27 | Novo Nordisk As | Anticuerpos procoagulantes mejorados |
| CN120433850A (zh) | 2018-08-07 | 2025-08-05 | 日本电信电话株式会社 | 光传输系统和传输模式选择方法 |
| CN113348000A (zh) * | 2018-09-17 | 2021-09-03 | 德克萨斯大学体系董事会 | 用于治疗骨损伤的组合物和方法 |
| WO2020089380A1 (en) | 2018-10-31 | 2020-05-07 | Bayer Aktiengesellschaft | REVERSAL AGENTS FOR NEUTRALIZING THE THERAPEUTIC ACTIVITY OF ANTI-FXIa ANTIBODIES |
| EP3914624A4 (en) * | 2019-01-21 | 2022-10-19 | Aronora, Inc. | NOVEL HUMANIZED ANTIBODIES AGAINST FACTOR XI HAVING ANTI-THROMBOTIC AND ANTI-INFLAMMATORY EFFECTS AND ASSOCIATED USES |
| CN113474374B (zh) | 2019-04-16 | 2025-05-02 | 四川科伦博泰生物医药股份有限公司 | 抗FXI/FXIa抗体及其用途 |
| CN110423278B (zh) | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| TWI882142B (zh) * | 2020-07-02 | 2025-05-01 | 大陸商北京拓界生物醫藥科技有限公司 | 抗FXI/FXIa抗體、其抗原結合片段及醫藥用途 |
| WO2024141099A1 (zh) * | 2022-12-30 | 2024-07-04 | 甘李药业股份有限公司 | 抗凝血因子XI和/或其活化形式因子XIa的抗体及其用途 |
| CN119454938B (zh) * | 2024-11-15 | 2025-07-25 | 广州骐骥生物科技有限公司 | 一种枸橼酸透析浓缩液及其制备方法 |
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| CN103619845B (zh) | 2011-04-21 | 2016-08-17 | 拜耳知识产权有限责任公司 | 氟烷基取代的吡唑并吡啶及其用途 |
| CA2844730A1 (en) | 2011-09-01 | 2013-03-07 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| JP6054967B2 (ja) | 2011-09-02 | 2016-12-27 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換アネレート化ピリミジンおよびその使用 |
| SI2847228T1 (sl) * | 2012-05-10 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Protitelesa zmožna vezave na faktor koagulacije XI in/ali njeno aktivirano obliko faktor XIa in njihove uporabe |
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2013
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- 2013-05-08 LT LTEP13721746.9T patent/LT2847228T/lt unknown
- 2013-05-08 AU AU2013258043A patent/AU2013258043B2/en not_active Ceased
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- 2013-05-08 US US14/400,281 patent/US9783614B2/en active Active
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- 2013-05-08 BR BR112014027952-7A patent/BR112014027952B1/pt active IP Right Grant
- 2013-05-08 SG SG10201609322QA patent/SG10201609322QA/en unknown
- 2013-05-08 KR KR1020147034253A patent/KR102060376B1/ko not_active Expired - Fee Related
- 2013-05-08 DK DK13721746.9T patent/DK2847228T3/en active
- 2013-05-08 CN CN201380037161.1A patent/CN104684932B/zh active Active
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- 2013-05-10 AR ARP130101638A patent/AR091024A1/es not_active Application Discontinuation
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- 2014-10-21 IL IL235238A patent/IL235238B/en active IP Right Grant
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2017
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2019
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