TWI602822B - Ｃ型肝炎病毒抑制劑 - Google Patents

Ｃ型肝炎病毒抑制劑 Download PDF

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Publication number
TWI602822B
TWI602822B TW102123626A TW102123626A TWI602822B TW I602822 B TWI602822 B TW I602822B TW 102123626 A TW102123626 A TW 102123626A TW 102123626 A TW102123626 A TW 102123626A TW I602822 B TWI602822 B TW I602822B
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TW102123626A
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TW201414740A (zh
Inventor
凱拉 伯恩森
傑若米 科特爾
艾許利 卡他那
卡皮爾 卡其
達若 加藤
約翰 林克
邊衡正
麥可 珊吉
亞當 史基瑞爾
達斯汀 賽吉兒
詹姆士 泰勒
金 崔倫
泰瑞莎 薛喬馬汀
藍道爾 維微安
楊征宇
傑夫 贊布洛奇
雪拉 希波菲爾
魯班 馬汀尼茲
巴頓 菲力浦斯
艾達 卡納利斯
小林徹也
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基利科學股份有限公司
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Application filed by 基利科學股份有限公司 filed Critical 基利科學股份有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
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TW102123626A 2012-07-03 2013-07-02 Ｃ型肝炎病毒抑制劑 TWI602822B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667806P 2012-07-03 2012-07-03
US201361798524P 2013-03-15 2013-03-15

Publications (2)

Publication Number Publication Date
TW201414740A TW201414740A (zh) 2014-04-16
TWI602822B true TWI602822B (zh) 2017-10-21

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TW102123626A TWI602822B (zh) 2012-07-03 2013-07-02 Ｃ型肝炎病毒抑制劑

Country Status (40)

Country Link
US (7) US9296782B2 (en:Method)
EP (4) EP3825312A1 (en:Method)
JP (4) JP6025977B2 (en:Method)
KR (3) KR102040023B1 (en:Method)
CN (2) CN106117309B (en:Method)
AP (1) AP3903A (en:Method)
AR (1) AR091661A1 (en:Method)
AU (6) AU2013286729B2 (en:Method)
BR (2) BR122021012378B1 (en:Method)
CA (1) CA2877005C (en:Method)
CL (1) CL2014003634A1 (en:Method)
CO (1) CO7160104A2 (en:Method)
CR (1) CR20150045A (en:Method)
CY (2) CY1118379T1 (en:Method)
DK (2) DK3159345T3 (en:Method)
EA (2) EA033961B1 (en:Method)
EC (1) ECSP15002066A (en:Method)
ES (3) ES2605383T3 (en:Method)
HR (2) HRP20161379T1 (en:Method)
HU (2) HUE042345T2 (en:Method)
IL (4) IL236500B (en:Method)
IN (1) IN2014MN02598A (en:Method)
LT (2) LT2870160T (en:Method)
MD (2) MD4602B1 (en:Method)
ME (2) ME02547B (en:Method)
MX (2) MX360597B (en:Method)
MY (1) MY173342A (en:Method)
NZ (2) NZ703064A (en:Method)
PE (1) PE20150204A1 (en:Method)
PH (3) PH12014502862A1 (en:Method)
PL (2) PL2870160T3 (en:Method)
PT (2) PT3159345T (en:Method)
RS (2) RS55494B1 (en:Method)
SG (3) SG11201408739VA (en:Method)
SI (2) SI3159345T1 (en:Method)
SM (3) SMT201900167T1 (en:Method)
TW (1) TWI602822B (en:Method)
UA (1) UA119315C2 (en:Method)
UY (1) UY34888A (en:Method)
WO (1) WO2014008285A1 (en:Method)

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