TWI591067B - 吡唑并吡啶及吡唑并嘧啶 - Google Patents

吡唑并吡啶及吡唑并嘧啶 Download PDF

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TWI591067B
TWI591067B TW104115312A TW104115312A TWI591067B TW I591067 B TWI591067 B TW I591067B TW 104115312 A TW104115312 A TW 104115312A TW 104115312 A TW104115312 A TW 104115312A TW I591067 B TWI591067 B TW I591067B
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Taiwan
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amino
methyl
phenyl
fluoro
pyrazolo
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TW104115312A
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Chinese (zh)
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TW201546071A (zh
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喬桑 瓦德斯瓦茲 柯
克里斯多弗 馬丁 德哈特
彼得 瓊斯
優格區 安尼爾 薩柏尼斯
喬瑟夫 威爾特 史托貝奇
佛羅里安 密切爾 瓦肯杭特
蓋文 阿里斯泰爾 惠特洛克
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輝瑞大藥廠
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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TW104115312A 2014-05-14 2015-05-13 吡唑并吡啶及吡唑并嘧啶 TWI591067B (zh)

Applications Claiming Priority (1)

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US201461993138P 2014-05-14 2014-05-14

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TWI591067B true TWI591067B (zh) 2017-07-11

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US (2) US9518052B2 (https=)
EP (1) EP3143021B1 (https=)
JP (1) JP6663857B2 (https=)
KR (1) KR20170002623A (https=)
CN (1) CN106459048A (https=)
AP (1) AP2016009562A0 (https=)
AR (1) AR100438A1 (https=)
AU (1) AU2015260905A1 (https=)
CA (1) CA2948587C (https=)
CL (1) CL2016002888A1 (https=)
CR (1) CR20160525A (https=)
CU (1) CU20160167A7 (https=)
DO (1) DOP2016000298A (https=)
EA (1) EA201650029A1 (https=)
EC (1) ECSP16087271A (https=)
ES (1) ES2737696T3 (https=)
GE (2) GEAP201814322A (https=)
IL (1) IL248970A0 (https=)
MD (1) MD20160121A2 (https=)
MX (1) MX2016014878A (https=)
NI (1) NI201600170A (https=)
PE (1) PE20161475A1 (https=)
PH (1) PH12016502228A1 (https=)
SG (1) SG11201609139WA (https=)
SV (1) SV2016005318A (https=)
TN (1) TN2016000503A1 (https=)
TW (1) TWI591067B (https=)
UY (1) UY36121A (https=)
WO (1) WO2015173683A1 (https=)

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CR20160525A (es) 2014-05-14 2016-12-20 Pfizer Pirazolopiridinas y pirazolopirimidinas
EP3712152B1 (en) 2015-11-03 2021-01-13 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
US10556901B2 (en) 2015-11-03 2020-02-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors
HK1252685A1 (zh) 2015-11-03 2019-05-31 Theravance Biopharma R&D Ip, Llc 用於治疗呼吸疾病的jak激酶抑制剂化合物
BR112019018648A2 (pt) 2017-03-09 2020-06-16 Theravance Biopharma R&D Ip, Llc Inibidores de jak contendo uma amida heterocíclica com 4 membros
CN110603255B (zh) 2017-05-01 2023-02-10 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的结晶型式
US10406148B2 (en) 2017-05-01 2019-09-10 Theravance Biopharma R&D Ip, Llc Methods of treatment using a JAK inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
MY200629A (en) 2017-08-01 2024-01-06 Theravance Biopharma R&D Ip Llc Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
EP3710431A4 (en) 2017-11-03 2021-07-07 Aclaris Therapeutics, Inc. SUBSTITUTED PYRROLOPYRIMIDINE-BASED JAK INHIBITORS AND THEIR MANUFACTURING AND USE PROCEDURES
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