TWI591067B - 吡唑并吡啶及吡唑并嘧啶 - Google Patents

吡唑并吡啶及吡唑并嘧啶 Download PDF

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TWI591067B
TWI591067B TW104115312A TW104115312A TWI591067B TW I591067 B TWI591067 B TW I591067B TW 104115312 A TW104115312 A TW 104115312A TW 104115312 A TW104115312 A TW 104115312A TW I591067 B TWI591067 B TW I591067B
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Taiwan
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amino
methyl
phenyl
fluoro
pyrazolo
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TW104115312A
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Chinese (zh)
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TW201546071A (zh
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喬桑 瓦德斯瓦茲 柯
克里斯多弗 馬丁 德哈特
彼得 瓊斯
優格區 安尼爾 薩柏尼斯
喬瑟夫 威爾特 史托貝奇
佛羅里安 密切爾 瓦肯杭特
蓋文 阿里斯泰爾 惠特洛克
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輝瑞大藥廠
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Neurology (AREA)
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TW104115312A 2014-05-14 2015-05-13 吡唑并吡啶及吡唑并嘧啶 TWI591067B (zh)

Applications Claiming Priority (1)

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US201461993138P 2014-05-14 2014-05-14

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TW201546071A TW201546071A (zh) 2015-12-16
TWI591067B true TWI591067B (zh) 2017-07-11

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US (2) US9518052B2 (Direct)
EP (1) EP3143021B1 (Direct)
JP (1) JP6663857B2 (Direct)
KR (1) KR20170002623A (Direct)
CN (1) CN106459048A (Direct)
AP (1) AP2016009562A0 (Direct)
AR (1) AR100438A1 (Direct)
AU (1) AU2015260905A1 (Direct)
CA (1) CA2948587C (Direct)
CL (1) CL2016002888A1 (Direct)
CR (1) CR20160525A (Direct)
CU (1) CU20160167A7 (Direct)
DO (1) DOP2016000298A (Direct)
EA (1) EA201650029A1 (Direct)
EC (1) ECSP16087271A (Direct)
ES (1) ES2737696T3 (Direct)
GE (2) GEAP201814322A (Direct)
IL (1) IL248970A0 (Direct)
MD (1) MD20160121A2 (Direct)
MX (1) MX2016014878A (Direct)
NI (1) NI201600170A (Direct)
PE (1) PE20161475A1 (Direct)
PH (1) PH12016502228A1 (Direct)
SG (1) SG11201609139WA (Direct)
SV (1) SV2016005318A (Direct)
TN (1) TN2016000503A1 (Direct)
TW (1) TWI591067B (Direct)
UY (1) UY36121A (Direct)
WO (1) WO2015173683A1 (Direct)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
CN106459048A (zh) 2014-05-14 2017-02-22 辉瑞公司 吡唑并吡啶类和吡唑并嘧啶类
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
EP3371184A1 (en) 2015-11-03 2018-09-12 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
KR20180073687A (ko) 2015-11-03 2018-07-02 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물
PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
AU2018231032B2 (en) 2017-03-09 2021-08-19 Theravance Biopharma R&D Ip, Llc JAK inhibitors containing a 4-membered heterocyclic amide
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
KR102568333B1 (ko) 2017-05-01 2023-08-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물을 사용하는 치료 방법
MX389014B (es) 2017-05-01 2025-03-20 Theravance Biopharma R&D Ip Llc Formas cristalinas de un compuesto inhibidor de jak
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