TWI580430B - 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽 - Google Patents

用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽 Download PDF

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Publication number
TWI580430B
TWI580430B TW100139078A TW100139078A TWI580430B TW I580430 B TWI580430 B TW I580430B TW 100139078 A TW100139078 A TW 100139078A TW 100139078 A TW100139078 A TW 100139078A TW I580430 B TWI580430 B TW I580430B
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Taiwan
Prior art keywords
peptide
fviii
amino acid
amino acids
seq
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TW100139078A
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English (en)
Chinese (zh)
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TW201231065A (en
Inventor
卡塔琳娜 諾拉 史坦尼茲
海登 寶拉 瑪莉亞 威爾漢密娜 凡
伯吉特 瑪莉亞 瑞伯特
漢斯 彼得 史瓦茲
哈穆 赫里基
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巴克斯歐塔公司
巴克斯歐塔有限公司
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Publication of TW201231065A publication Critical patent/TW201231065A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
TW100139078A 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽 TWI580430B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40740210P 2010-10-27 2010-10-27
US201161467894P 2011-03-25 2011-03-25
US201161502476P 2011-06-29 2011-06-29

Publications (2)

Publication Number Publication Date
TW201231065A TW201231065A (en) 2012-08-01
TWI580430B true TWI580430B (zh) 2017-05-01

Family

ID=45349271

Family Applications (3)

Application Number Title Priority Date Filing Date
TW100139078A TWI580430B (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽
TW105138248A TW201708251A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽
TW106113613A TW201730205A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW105138248A TW201708251A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽
TW106113613A TW201730205A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之ｆｖｉｉｉ胜肽

Country Status (20)

Country Link
US (3) US8969524B2 (enExample)
EP (2) EP2632479B1 (enExample)
JP (2) JP6122780B2 (enExample)
KR (2) KR102222864B1 (enExample)
CN (2) CN104926947A (enExample)
AR (1) AR083586A1 (enExample)
AU (2) AU2011319747C1 (enExample)
BR (1) BR112013010362A2 (enExample)
CA (1) CA2815239C (enExample)
DK (1) DK2632479T3 (enExample)
EA (1) EA034494B1 (enExample)
ES (2) ES2639039T3 (enExample)
HK (1) HK1215442A1 (enExample)
MX (1) MX347805B (enExample)
NZ (2) NZ609474A (enExample)
PL (2) PL3260132T3 (enExample)
PT (1) PT2632479T (enExample)
SG (2) SG10201600656WA (enExample)
TW (3) TWI580430B (enExample)
WO (1) WO2012058480A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063031A2 (en) 2004-12-06 2006-06-15 Haplomics Allelic variants of human factor viii
CN104903347B (zh) * 2012-11-12 2020-02-21 艾匹托普国际股份有限公司 肽
US10272163B2 (en) 2012-12-07 2019-04-30 The Regents Of The University Of California Factor VIII mutation repair and tolerance induction
US20160038575A1 (en) * 2013-03-15 2016-02-11 Haplomics, Inc. Compositions and methods for immune tolerance induction to factor viii replacement therapies in subjects with hemophilia a
JP6488376B2 (ja) * 2014-06-12 2019-03-20 ユニヴァーシティ オブ ハワイＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈａｗａｉｉ 免疫原性を低減するかまたは予防するためのヒト化コブラ毒因子を含む医薬組成物、薬剤および組み合わせ医薬
EP3250602A1 (en) * 2015-01-26 2017-12-06 Cellectis T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm
CN109804432B (zh) 2016-04-15 2023-07-14 武田药品工业株式会社 提供药代动力学药物给药方案的方法和设备
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256304A1 (en) * 2002-04-18 2005-11-17 Tim Jones Modified factor VIII

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485314B2 (en) * 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
EP1766412B1 (en) * 2004-05-21 2009-04-01 The Institute for Systems Biology Compositions and methods for quantification of serum glycoproteins
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
GB0723712D0 (en) 2007-12-04 2008-01-16 Apitope Technology Bristol Ltd Peptides
US7673687B2 (en) 2007-12-05 2010-03-09 Halliburton Energy Services, Inc. Cement compositions comprising crystalline organic materials and methods of using same
DE202007017320U1 (de) 2007-12-07 2008-02-28 Dittmann, Ludwig Vorrichtung zur Raumbeduftung
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
US20110081362A1 (en) 2008-01-31 2011-04-07 The Brigham And Women's Hospital, Inc. Treatment of cancer
EP2385825B1 (en) 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256304A1 (en) * 2002-04-18 2005-11-17 Tim Jones Modified factor VIII

Also Published As

Publication number Publication date
EA034494B1 (ru) 2020-02-13
PL3260132T3 (pl) 2022-08-08
US20150203567A1 (en) 2015-07-23
TW201708251A (zh) 2017-03-01
PL2632479T3 (pl) 2017-09-29
AU2011319747C1 (en) 2016-07-14
US9512198B2 (en) 2016-12-06
AU2011319747B2 (en) 2016-01-07
EP3260132B1 (en) 2022-02-09
KR102222864B1 (ko) 2021-03-04
US20120135019A1 (en) 2012-05-31
US8969524B2 (en) 2015-03-03
CA2815239C (en) 2019-02-26
EP2632479B1 (en) 2017-06-14
JP2017095463A (ja) 2017-06-01
WO2012058480A1 (en) 2012-05-03
BR112013010362A2 (pt) 2016-08-02
TW201730205A (zh) 2017-09-01
ES2912455T3 (es) 2022-05-26
MX347805B (es) 2017-05-15
AR083586A1 (es) 2013-03-06
CN103298482A (zh) 2013-09-11
NZ609474A (en) 2015-06-26
CA2815239A1 (en) 2012-05-03
SG10201600656WA (en) 2016-02-26
AU2016202155B2 (en) 2018-02-01
JP6122780B2 (ja) 2017-04-26
HK1215442A1 (zh) 2016-08-26
JP2014505014A (ja) 2014-02-27
PT2632479T (pt) 2017-07-24
ES2639039T3 (es) 2017-10-25
MX2013004753A (es) 2013-09-13
KR102040867B1 (ko) 2019-11-07
CN103298482B (zh) 2015-08-19
KR20190126189A (ko) 2019-11-08
US20170267743A1 (en) 2017-09-21
AU2016202155A1 (en) 2016-04-28
EA201390617A1 (ru) 2013-10-30
KR20130128404A (ko) 2013-11-26
TW201231065A (en) 2012-08-01
NZ703514A (en) 2017-02-24
AU2011319747A1 (en) 2013-05-02
EP3260132A1 (en) 2017-12-27
EP2632479A1 (en) 2013-09-04
DK2632479T3 (en) 2017-08-07
CN104926947A (zh) 2015-09-23
SG189914A1 (en) 2013-06-28

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