TWI504418B - 包含奧澤沙星之醫藥局部組成物及其用途 - Google Patents
包含奧澤沙星之醫藥局部組成物及其用途 Download PDFInfo
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- TWI504418B TWI504418B TW098135341A TW98135341A TWI504418B TW I504418 B TWI504418 B TW I504418B TW 098135341 A TW098135341 A TW 098135341A TW 98135341 A TW98135341 A TW 98135341A TW I504418 B TWI504418 B TW I504418B
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Landscapes
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| TW103134727A TW201511779A (zh) | 2008-10-17 | 2009-10-19 | 包含奧澤沙星之醫藥局部組成物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2792018A1 (en) * | 2010-05-10 | 2011-11-17 | Segetis, Inc. | Fragrant formulations, methods of manufacture thereof and articles comprising the same |
| US9458414B2 (en) | 2012-09-21 | 2016-10-04 | Gfbiochemicals Limited | Cleaning, surfactant, and personal care compositions |
| DE102013226507B4 (de) | 2013-12-18 | 2022-05-05 | Ashland Industries Europe Gmbh | Konzentrat umfassend Ferulasäureethylester und Arylalkanol und dessen Verwendung |
| EP3967312A1 (en) * | 2014-09-12 | 2022-03-16 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
| KR20170117077A (ko) * | 2015-02-13 | 2017-10-20 | 마루호 코 엘티디 | 피리돈카르복실산계 유도체를 함유하는 외용제 |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
| JP7347915B2 (ja) * | 2016-04-28 | 2023-09-20 | マルホ株式会社 | 抗菌剤 |
| WO2018048042A1 (ko) * | 2016-09-12 | 2018-03-15 | 주식회사 가나씨앤에이치 | 글리세린 젖산 에스테르를 유효성분으로 하는 방부 및 항균용 외용제 조성물 |
| WO2018101443A1 (ja) * | 2016-12-01 | 2018-06-07 | マルホ株式会社 | 医療用皮膚外用剤 |
| US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
| CN113712913A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种奥泽沙星混悬滴眼液组合物 |
| US11724077B2 (en) * | 2021-07-28 | 2023-08-15 | Subhash Dhawan | Therapeutic swabs for treating upper respiratory infections |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002356426A (ja) * | 2001-03-26 | 2002-12-13 | Toyama Chem Co Ltd | ピリドンカルボン酸系化合物を含有する皮膚外用剤 |
| EP1698336A1 (en) * | 2005-03-01 | 2006-09-06 | Ferrer Internacional, S.A. | Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04243827A (ja) * | 1991-01-25 | 1992-08-31 | Sumitomo Pharmaceut Co Ltd | プロスタグランジン誘導体含有溶解型軟膏剤 |
| JP3174590B2 (ja) * | 1991-04-04 | 2001-06-11 | テルモ株式会社 | ステロイド軟膏剤 |
| FR2728166A1 (fr) * | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
| JP3162335B2 (ja) * | 1998-03-11 | 2001-04-25 | ユーナイテッド ネイションズ デベロップメント プログラム | 皮膚真菌感染症治療用の植物薬剤、その製造法と用途 |
| CN1152029C (zh) * | 1998-04-06 | 2004-06-02 | 富山化学工业株式会社 | 喹喏酮羧酸衍生物及其盐 |
| AU780358B2 (en) * | 1999-06-08 | 2005-03-17 | Lorantis Limited | Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway |
| JP4384402B2 (ja) | 2001-11-30 | 2009-12-16 | 富山化学工業株式会社 | デスフルオロピリドンカルボン酸系化合物を含有する水溶液剤およびその粉末化物並びにそれら製造方法 |
| EP1731138B1 (en) | 2004-03-31 | 2016-03-23 | Toyama Chemical Co., Ltd. | Fine dispersion of sparingly soluble drug and process for producing the same |
| JP4393552B2 (ja) | 2005-08-01 | 2010-01-06 | マルホ株式会社 | ピリドンカルボン酸誘導体を含有するローション剤 |
| JP5112669B2 (ja) | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002356426A (ja) * | 2001-03-26 | 2002-12-13 | Toyama Chem Co Ltd | ピリドンカルボン酸系化合物を含有する皮膚外用剤 |
| EP1698336A1 (en) * | 2005-03-01 | 2006-09-06 | Ferrer Internacional, S.A. | Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent |
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