TWI461428B - 蔥環黴素衍生結合物，其製備方法及作為抗腫瘤化合物之用途 - Google Patents
蔥環黴素衍生結合物，其製備方法及作為抗腫瘤化合物之用途 Download PDFInfo
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- TWI461428B TWI461428B TW098123764A TW98123764A TWI461428B TW I461428 B TWI461428 B TW I461428B TW 098123764 A TW098123764 A TW 098123764A TW 98123764 A TW98123764 A TW 98123764A TW I461428 B TWI461428 B TW I461428B
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- Prior art keywords
- antibody
- formula
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- 0 CCC(CCCC(C)C1)CC1(C(COC(CI)N*C)=O)O Chemical compound CCC(CCCC(C)C1)CC1(C(COC(CI)N*C)=O)O 0.000 description 4
- BTLPUHVPOQZHGV-UHFFFAOYSA-N CNNC1=[IH](CC2)[I]2C=CC=C1 Chemical compound CNNC1=[IH](CC2)[I]2C=CC=C1 BTLPUHVPOQZHGV-UHFFFAOYSA-N 0.000 description 1
- JDFXJJLFADUZIY-UHFFFAOYSA-N CON(C(CC1)=O)C1=O Chemical compound CON(C(CC1)=O)C1=O JDFXJJLFADUZIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8094408P | 2008-07-15 | 2008-07-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201011041A TW201011041A (en) | 2010-03-16 |
| TWI461428B true TWI461428B (zh) | 2014-11-21 |
Family
ID=41404334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098123764A TWI461428B (zh) | 2008-07-15 | 2009-07-14 | 蔥環黴素衍生結合物，其製備方法及作為抗腫瘤化合物之用途 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8900589B2 (enExample) |
| EP (1) | EP2303332B1 (enExample) |
| JP (2) | JP6067222B2 (enExample) |
| KR (1) | KR101667062B1 (enExample) |
| CN (1) | CN102159248B (enExample) |
| AR (1) | AR072804A1 (enExample) |
| AU (1) | AU2009270988A1 (enExample) |
| BR (1) | BRPI0910810A2 (enExample) |
| CA (1) | CA2727915C (enExample) |
| ES (1) | ES2532635T3 (enExample) |
| IL (1) | IL210003A0 (enExample) |
| MX (1) | MX2011000509A (enExample) |
| PE (1) | PE20110571A1 (enExample) |
| RU (1) | RU2523419C2 (enExample) |
| SG (1) | SG192517A1 (enExample) |
| TW (1) | TWI461428B (enExample) |
| WO (1) | WO2010009124A2 (enExample) |
| ZA (1) | ZA201009122B (enExample) |
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| PE20110571A1 (es) | 2011-08-29 |
| BRPI0910810A2 (pt) | 2019-09-24 |
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| AU2009270988A1 (en) | 2010-01-21 |
| CA2727915A1 (en) | 2010-01-21 |
| CN102159248B (zh) | 2013-09-11 |
| ZA201009122B (en) | 2012-03-28 |
| JP2011528360A (ja) | 2011-11-17 |
| HK1157660A1 (en) | 2012-07-06 |
| JP2016006045A (ja) | 2016-01-14 |
| KR101667062B1 (ko) | 2016-10-17 |
| RU2523419C2 (ru) | 2014-07-20 |
| TW201011041A (en) | 2010-03-16 |
| RU2011105402A (ru) | 2012-08-20 |
| ES2532635T3 (es) | 2015-03-30 |
| CN102159248A (zh) | 2011-08-17 |
| US20150051380A1 (en) | 2015-02-19 |
| US8900589B2 (en) | 2014-12-02 |
| US8389697B2 (en) | 2013-03-05 |
| AR072804A1 (es) | 2010-09-22 |
| US9695240B2 (en) | 2017-07-04 |
| WO2010009124A2 (en) | 2010-01-21 |
| EP2303332B1 (en) | 2014-12-31 |
| MX2011000509A (es) | 2011-04-05 |
| EP2303332A2 (en) | 2011-04-06 |
| SG192517A1 (en) | 2013-08-30 |
| JP6067222B2 (ja) | 2017-01-25 |
| US20100034837A1 (en) | 2010-02-11 |
| KR20110040922A (ko) | 2011-04-20 |
| WO2010009124A3 (en) | 2010-12-23 |
| IL210003A0 (en) | 2011-02-28 |
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