TWI437988B - 包含N-(5-第三丁基-異噁唑-3-基)-N’-{4-〔7-(2-嗎啉-4-基-乙氧基)咪唑并〔2,1-b〕〔1,3〕苯并噻唑-2-基〕苯基}脲之固體形式物、其組合物及與其有關之用途 - Google Patents

包含N-(5-第三丁基-異噁唑-3-基)-N’-{4-〔7-(2-嗎啉-4-基-乙氧基)咪唑并〔2,1-b〕〔1,3〕苯并噻唑-2-基〕苯基}脲之固體形式物、其組合物及與其有關之用途 Download PDF

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TWI437988B
TWI437988B TW097136260A TW97136260A TWI437988B TW I437988 B TWI437988 B TW I437988B TW 097136260 A TW097136260 A TW 097136260A TW 97136260 A TW97136260 A TW 97136260A TW I437988 B TWI437988 B TW I437988B
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compound
certain embodiments
xrpd
salt
hcl salt
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TW097136260A
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Chinese (zh)
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TW200920360A (en
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Shripad Bhagwat
Wei Lai
Stephan D Parent
Melanie J Roe
Alan Schwartz
Valeriya N Smolenskaya
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Ambit Biosciences Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

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TW097136260A 2007-09-19 2008-09-19 包含N-(5-第三丁基-異噁唑-3-基)-N’-{4-〔7-(2-嗎啉-4-基-乙氧基)咪唑并〔2,1-b〕〔1,3〕苯并噻唑-2-基〕苯基}脲之固體形式物、其組合物及與其有關之用途 TWI437988B (zh)

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US99463507P 2007-09-19 2007-09-19

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TW200920360A TW200920360A (en) 2009-05-16
TWI437988B true TWI437988B (zh) 2014-05-21

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MX (1) MX2010002295A (enExample)
PL (1) PL2201018T3 (enExample)
SI (1) SI2201018T1 (enExample)
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CN103172648B (zh) * 2011-12-20 2016-05-25 上海迪诺医药科技有限公司 三杂环衍生物、制备方法及应用
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CN104513257B (zh) * 2013-09-26 2017-02-15 广东东阳光药业有限公司 取代脲衍生物及其在药物中的应用
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
CN109251181B (zh) * 2017-07-13 2021-08-31 广东东阳光药业有限公司 取代脲衍生物的盐及其在药物中的应用
CN110763544A (zh) * 2019-09-20 2020-02-07 南京聚谱检测科技有限公司 一种激光剥蚀样品制靶用快干可精磨粘合剂
CN111413421A (zh) * 2020-02-20 2020-07-14 广东电科院能源技术有限责任公司 污泥燃烧后灰尘中氯离子含量的测试方法、控制方法

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ES2436266T3 (es) * 2007-11-08 2013-12-30 Ambit Biosciences Corporation Métodos para administrar N-(5-terc-butil-isoxazol-3-il)-N'-{4-[7-(2-morfolin-4-il-etoxi)imidazo[2,1-b][1,3]benzotiazol-2-il]fenil}urea para tratar enfermedades proliferativas

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CA2696776C (en) 2015-12-15
HUE027982T2 (en) 2016-11-28
KR20100061734A (ko) 2010-06-08
ES2573292T9 (es) 2016-07-08
ES2573292T3 (es) 2016-06-07
WO2009038757A3 (en) 2009-05-28
AU2008302744A1 (en) 2009-03-26
PL2201018T3 (pl) 2016-11-30
BRPI0816904A2 (pt) 2015-03-17
US8883783B2 (en) 2014-11-11
AU2008302744B2 (en) 2014-01-30
MX2010002295A (es) 2010-03-22
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US20090131426A1 (en) 2009-05-21
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CY1117583T1 (el) 2017-04-26
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US9585892B2 (en) 2017-03-07
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EP2201018B1 (en) 2016-03-16
US20150238499A1 (en) 2015-08-27
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DK2201018T3 (en) 2016-05-17
CN101868465A (zh) 2010-10-20
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