TWI333861B - Enteric coated solid dosage form of mycophenolic acid or its salt, and process for preparing the same - Google Patents
Enteric coated solid dosage form of mycophenolic acid or its salt, and process for preparing the same Download PDFInfo
- Publication number
- TWI333861B TWI333861B TW091123694A TW91123694A TWI333861B TW I333861 B TWI333861 B TW I333861B TW 091123694 A TW091123694 A TW 091123694A TW 91123694 A TW91123694 A TW 91123694A TW I333861 B TWI333861 B TW I333861B
- Authority
- TW
- Taiwan
- Prior art keywords
- mycophenolate
- ingot
- casing
- salt
- coating
- Prior art date
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- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title claims description 80
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title claims description 78
- 229960000951 mycophenolic acid Drugs 0.000 title claims description 28
- 150000003839 salts Chemical class 0.000 title claims description 11
- 239000007909 solid dosage form Substances 0.000 title description 9
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- 238000000576 coating method Methods 0.000 claims description 49
- 239000011248 coating agent Substances 0.000 claims description 40
- 229940014456 mycophenolate Drugs 0.000 claims description 37
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
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Landscapes
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| AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
| CN101052631A (zh) * | 2004-07-20 | 2007-10-10 | 特瓦药厂私人有限公司 | 结晶霉酚酸钠 |
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| WO2006086498A2 (en) * | 2005-02-08 | 2006-08-17 | Aspreva Pharmaceuticals Sa | Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors |
| WO2006086500A2 (en) * | 2005-02-08 | 2006-08-17 | Aspreva Pharmaceuticals Sa | Compositions and methods for treating vascular, autoimmune and inflammatory diseases |
| EP1940388A2 (en) * | 2005-09-30 | 2008-07-09 | Novartis AG | Dpp iv inhibtor for use in the treatment of autoimmune diseases and graft rejection |
| EP1965760B1 (de) | 2005-12-21 | 2013-02-27 | Basf Se | Feinteiliges quervernetztes polyvinylpyrrolidon als tablettensprengmittel |
| CA2640283A1 (en) * | 2006-02-13 | 2007-08-23 | Novartis Ag | High dosage of mycophenolic acid (mpa) |
| WO2008148742A2 (de) | 2007-06-06 | 2008-12-11 | Basf Se | Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten |
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| MX2010001711A (es) * | 2007-08-13 | 2010-03-11 | Panacea Biotec Ltd | Composiciones de liberacion extendida que comprenden micofenolato sodico y procedimientos de las mismas. |
| AU2009220779A1 (en) * | 2008-03-05 | 2009-09-11 | Panacea Biotec Limited | Modified release pharmaceutical compositions comprising mycophenolate and processes thereof |
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| JP7385474B2 (ja) * | 2017-03-13 | 2023-11-22 | オカヴァ ファーマシューティカルズ， インコーポレイテッド | 非ヒト哺乳動物にミコフェノール酸活性剤を送達すための方法および組成物 |
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| WO2019238647A1 (en) * | 2018-06-14 | 2019-12-19 | Poxel | Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes |
| RU2723255C2 (ru) * | 2018-11-14 | 2020-06-09 | Общество с ограниченной ответственностью "Изварино Фарма" | Экструдат с микофенолятом натрия для получения пероральной твердой лекарственной формы |
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