TWI251492B - Pharmaceutical composition containing botulinum neurotoxin and novel use thereof - Google Patents

Pharmaceutical composition containing botulinum neurotoxin and novel use thereof Download PDF

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Publication number
TWI251492B
TWI251492B TW089111212A TW89111212A TWI251492B TW I251492 B TWI251492 B TW I251492B TW 089111212 A TW089111212 A TW 089111212A TW 89111212 A TW89111212 A TW 89111212A TW I251492 B TWI251492 B TW I251492B
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TW
Taiwan
Prior art keywords
botulinum
neurotoxin
complex
neurotoxins
treatment
Prior art date
Application number
TW089111212A
Other languages
English (en)
Chinese (zh)
Inventor
Bigalke Hans
Frevert Jurgen
Original Assignee
Merz Pharma Gmbh & Co Kgaa
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Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW089111212A 1999-06-07 2000-08-24 Pharmaceutical composition containing botulinum neurotoxin and novel use thereof TWI251492B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19925739A DE19925739A1 (de) 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin

Publications (1)

Publication Number Publication Date
TWI251492B true TWI251492B (en) 2006-03-21

Family

ID=7910318

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089111212A TWI251492B (en) 1999-06-07 2000-08-24 Pharmaceutical composition containing botulinum neurotoxin and novel use thereof

Country Status (26)

Country Link
US (3) US7964199B1 (enExample)
EP (1) EP1185291B2 (enExample)
JP (2) JP2003505343A (enExample)
KR (1) KR100466407B1 (enExample)
CN (2) CN101062009A (enExample)
AR (1) AR024306A1 (enExample)
AT (1) ATE258803T1 (enExample)
AU (1) AU774590B2 (enExample)
CA (1) CA2376193C (enExample)
CO (1) CO5170431A1 (enExample)
CZ (1) CZ20014351A3 (enExample)
DE (3) DE19925739A1 (enExample)
DK (1) DK1185291T3 (enExample)
EA (1) EA004202B1 (enExample)
ES (1) ES2215056T5 (enExample)
GE (1) GEP20043200B (enExample)
HU (1) HUP0201530A3 (enExample)
IL (2) IL146974A0 (enExample)
MX (1) MXPA01012540A (enExample)
NO (1) NO20015964L (enExample)
PL (1) PL198958B1 (enExample)
PT (1) PT1185291E (enExample)
TW (1) TWI251492B (enExample)
UA (1) UA72253C2 (enExample)
WO (1) WO2000074703A2 (enExample)
ZA (1) ZA200110074B (enExample)

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US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
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US7140371B2 (en) 2002-03-14 2006-11-28 Allergan, Inc. Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins
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US6838434B2 (en) * 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
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KR102724651B1 (ko) * 2021-07-08 2024-11-01 주식회사 파마리서치바이오 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법
TW202400122A (zh) 2022-02-28 2024-01-01 德商梅茲製藥有限兩合公司 肉毒桿菌毒素用於降低皮膚毛孔尺寸及／或皮脂產生之用途、以及降低皮膚毛孔尺寸及／或皮脂產生的方法
CN120379640A (zh) 2022-11-28 2025-07-25 莫茨药物股份两合公司 用于颈部年轻化的高浓度肉毒杆菌毒素治疗
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WO2024194181A1 (en) 2023-03-20 2024-09-26 Merz Therapeutics GmbH Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient
AU2024274999A1 (en) 2023-05-23 2025-11-13 Merz Therapeutics GmbH Botulinum toxin for treating peripheral neuropathic pain
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WO2025228877A1 (en) 2024-04-29 2025-11-06 Merz Therapeutics GmbH Botulinum toxin for the preventive treatment of migraine

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PT1185291E (pt) 2004-06-30
WO2000074703A2 (de) 2000-12-14
KR20020008214A (ko) 2002-01-29
CO5170431A1 (es) 2002-06-27
WO2000074703B1 (de) 2001-06-07
GEP20043200B (en) 2004-03-25
ATE258803T1 (de) 2004-02-15
NO20015964D0 (no) 2001-12-06
AU5804700A (en) 2000-12-28
PL352468A1 (en) 2003-08-25
ES2215056T5 (es) 2011-03-15
JP2007238627A (ja) 2007-09-20
US7964199B1 (en) 2011-06-21
EA200200017A1 (ru) 2002-06-27
EP1185291B2 (de) 2010-10-27
DE19925739A1 (de) 2000-12-21
US8398998B2 (en) 2013-03-19
NO20015964L (no) 2002-01-30
IL146974A0 (en) 2002-08-14
HUP0201530A3 (en) 2002-10-28
CA2376193A1 (en) 2000-12-14
EP1185291B1 (de) 2004-02-04
AR024306A1 (es) 2002-09-25
EP1185291A2 (de) 2002-03-13
EA004202B1 (ru) 2004-02-26
AU774590B2 (en) 2004-07-01
US20110217287A1 (en) 2011-09-08
UA72253C2 (uk) 2005-02-15
CN101062009A (zh) 2007-10-31
CZ20014351A3 (cs) 2002-06-12
DK1185291T3 (da) 2004-04-05
WO2000074703A3 (de) 2001-04-26
HUP0201530A2 (en) 2002-09-28
US20120088732A1 (en) 2012-04-12
IL146974A (en) 2007-05-15
ZA200110074B (en) 2003-03-06
CN1354670A (zh) 2002-06-19
KR100466407B1 (ko) 2005-01-27
HK1047403A1 (zh) 2003-02-21
DE50005208D1 (de) 2004-03-11
CN100389820C (zh) 2008-05-28
PL198958B1 (pl) 2008-08-29
JP2003505343A (ja) 2003-02-12
DE10081516D2 (de) 2001-09-13
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MXPA01012540A (es) 2004-09-27

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