TWI231755B - An interpositional articular implant and the method for making the same - Google Patents
An interpositional articular implant and the method for making the same Download PDFInfo
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- TWI231755B TWI231755B TW092127826A TW92127826A TWI231755B TW I231755 B TWI231755 B TW I231755B TW 092127826 A TW092127826 A TW 092127826A TW 92127826 A TW92127826 A TW 92127826A TW I231755 B TWI231755 B TW I231755B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
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- Y10T29/49—Method of mechanical manufacture
Description
1231755 玖、發明說明: 【韻^明戶斤屬之_技^員域^ 相關申請案之交互參照 本案請求下列美國臨時專利申請案之優先權,美國臨 5時專利申5月案60/416,601,申請人Philipp Lang,申請曰2002 年10月7日,名稱「具有三維幾何形狀匹配關節面之最小侵 襲性關節植入物」,以及美國臨時專利申請案6〇/467,686, 申明人Philipp Lang、Daniel Steines、Hacene Bouadi、David Miller、Barry J· Linder及 Cecily Anne Snyder,申請日 2003 10年5月2日,名稱「關節植入物」。 發明領域 本發明係關於骨科植入物及系統。該植入物為關節植 入物及/或嵌置型關節植入物。本發明亦係關於植入物設 計、製造、模組化及植入方法,以及用於該等方法之手術 15工具及套件組。本發明亦係關於適合藉關節鏡插入之可自 我膨脹之骨科植入物及其外廓變化。最後本發明係關於關 節植入物’該種關節植入物係成形為植入物可重建正常或 接近正常的三維關節幾何形狀或對正,且可輔助關節移動 超過關節正常移動範圍之6〇〇/。至99.9%,且可忍受於移動期 2〇 間施加於關節高達100%的正常剪力。 發明背景 有多種不同類型的軟骨,例如透明軟骨及纖維軟骨。 透明軟骨出現於例如關節的關節骨面,透明軟骨負責提供 愁動==利滑動特徵。關節軟骨牢固附著於下方骨 關節的=,關節軟骨典型厚度小於5毫米,厚度依據 化。此外別依據於關節内部的所在位置而有顯著變 關碎軟骨不含神經、不含血管 的敕骨倍粒雔去i &且無淋巴。成人 雙重擴散系統獲得營養,該雙重Μ㈣将妳 由滑_心#4擴政糸統係經 胞出^ 緊密基體而到達軟骨細胞,軟骨細 出見於軟骨結缔組織。 因類的修補能力有限;因此軟骨因病而受損例如 Γ關節炎及/或骨關節炎或外傷而受損,可能導致 2的肉體畸形及衰弱無力。此外隨著人類關節軟骨的老 ’軟骨的拉力性質改變。如此成人軟骨之抗拉挺度及抗 強度因老化過程結果,㈣時_經過而顯著下降。 、例如’膝關節軟骨的錢區段之拉力強度的增加至三 十歲為止,隨後隨著年齡而顯著下降,於關節面出現可伯 測的第二型膠原損傷。深部區段軟骨隨著年齡的老化,抗 拉強度也逐漸降低,但膠原含量未見減少。此項觀察指示 軟骨的機械組織以及因而軟骨的結構組織隨著老化改變, 若充分演變之後可能造成軟骨容易受到創傷的損壞。 ’通常嚴重的軟骨損傷或損失係使用例如整形修補用的 聚矽氧或適當金屬合金等贗復材料來置換關節。例如參考 ’ 2002年5月7日核發給Schmotzer之美國專利第6,383,228 號;2001年3月20日核發給Afriat等人之美國專利第 6,203,576號;2000年10月3日核發給Ateshian等人之美國專 利第6,126,690號。此等贗復材料的植入通常也造成下方組 ^31755 、、哉及骨質的流失而未能回復原先軟骨所允許的完整功能。 使用某些裝置,隨著組織及骨質的大量流失可能導致嚴重 長期併發症,包括感染、骨質溶解,以及植入物的鬆脫。 如一般了解,關節成形術有高度侵襲性,需要手術切 5 開整個或大部分需要修補的一或多個骨骼的關節面。典型 地’採用此等手術,髓腔被相當徹底地鑽空來將贗復物的 莖部齧合於骨骼内部。鑽空結果導致病人骨質存量的流 失’隨著時間的經過,骨質溶解經常導致贗復物的鬆脫。 此外’植入物與骨骼緊密齧合區隨著時間的經過而劣化, 1〇 結果最終導致需要更換贗復物。由於病人骨質的存量有 限’關節成形術可進行更換手術的次數也有限。簡言之, 經過15至20年時間,某些病例時間甚至更短,病人已經沒 有任何可從事的治療選項,結果只能留下疼痛且無功能的 關節。 15 使用基體、組織支架或其它植入有細胞(例如軟骨細 胞、軟骨親代細胞、基質細胞、間葉幹細胞等)之載架也描 述為軟骨修補的可能治療之道。例如參考1999年10月14曰 公告之Fofonoff之國際公告案WO 99/51719 ; 2001年12月6 日公告之Simon等人之WO 01/91672;以及2001年3月15日 20 公告之Mansmann之WO 01/17463 ;以及2001年9月4日核發 給Vibe-Hansen等人之美國專利第6,283,980號;1998年12月 1曰核發給Naughton等人之5,842,477 ; 1998年6月23日核發 給8比\¥&血之5,769,899;1986年9月2日核發給€&卩1&11等人之 4,609,551 ; 1991 年8月 20 日核發給Vacanti等人之5,041,138 ; 8 1231755 1993年3月30曰核發給Caplan等人之5,197,985 ; 1993年7月 13曰核發給Caplan等人之5,226,914 ; 2001年12月11日核發 給Hardwick等人之6,328,765 ; 2001 年8月 28 日核發給Rueger 等人之6,281,195 ;以及1989年7月11日核發給^⑽如之 5 4,846,835。但使用生物置換材料例如同種異體移植物系統 及自體移植物系統及組織支架之臨床結果不確定,原因在 於大部分此等置換材料無法達成類似預期修補的人類組織 於正常無病狀況下的形狀排列或結構。此外此等生物置換 材料的機械耐用性仍未確定。 3 應年3月21日核發給Fell等人之美國專利第I·,927 號及2003年5月6日核發紐轉人之美國專利第6,558,421 破揭不-種無需骨路切開的可手術植入膝屬復物。此種廣 復物的形狀被描述為橢圓形有—或多個筆直緣。如此,此 等褒置並未設計成實質上隨形於活體内其餘軟骨之實際形 ;狀(輪廓)及/或潛在骨路的形狀。如此由於病人周_軟骨及/ 或下方軟骨下骨路與贗復物間的厚度差異及曲率差異,結 果導致植入物的整合—體極端困難。 如此仍然需要有—種使用—或多種植入零組件而複製 關即天㈣何形狀之系統及方法,該植人物可以最小侵襲 技術植人々及製造此等修補物及植人具4以及 介於關節之二關節面間重新形成天然或接近天然的三維幾 何形狀關係之方法。 C 明内容;j 發明概要 1231755 、…本發明提供修補關節之方法及組成物,特別可用於修 補關節軟骨以及輔助多種軟骨及骨路修補材料整合於個體 之裝置及植入物。此處所述技術允許製造實質隨形於或完 全隨形於特定個體下方軟骨及/或骨路及/或其它關節面之 5輪靡之裝置。此外,該褒置較佳實質順形於或完全順形於 軟骨形狀(尺寸)。當關節軟骨面之形狀(例如尺寸、厚度及/ =曲率)為解職合或接近解魏合未受損軟骨、個體原先 軟骨、及/或下方骨糾,修補的成功率提升。 修補材料可於植入前成形,此種成形例如可基於電子 1〇影像二電子影像提供有關環繞患病軟骨缺損或區域之任何 正吊」之曲率或厚度、及/或有關患病軟骨缺損或區域下 方或周圍骨路之曲率資訊,以及包含關節之兩相對匹配面 之骨骼及/或軟骨資訊。 本發明提供最小侵襲性之部分關節置換方法。本方法 15將導致手術造成骨質存量之流失極小或無流失。如此此處 況月方法經由達成植入物與周圍或鄰近軟骨及/或軟骨下 月絡間之解剖齧合或接近解剖齧合來回復關節面的完整 性。 至90_99·9%,最佳改善至%,9% 98-99.9% 〇 大部分病例,修補後關節的關節活動性係在正常活動 的60/。至99.9%範圍。活動範圍改善至85_99 9%,更佳改善 理想上係改善至 此外’植人本發明裝置所需要的切開典型比目前植入 物植人時需要的切開小5〇%。例如全膝置換典型係採用切 20 1231755 開6-12吋(15-30厘米),而單腔膝置換只需要切開3吋(7厘 米)。設計用來修補脛骨面之本發明植入物只須切開3厘米 (約1.5吋),而用來修補脛骨面及股骨髁二者的植入物組合 只須切開3吋(7厘米)。舉另一例,傳統髖骨置換手術需要單 5 一切開6至12叶(15-30厘米)’或侵襲性較低的手術需要作兩 個1·5-4吋(3-9.5厘米)的切開。根據本發明設計用來修補髖 臼的植入物,依據單次表面矯正或雙重表面矯正而定,只 須單一切開1·5忖(3厘米)至6对(3〇厘米)。 本發明之優點包括(但非限制性)⑴依據個別病人量身 10訂製關節修補(例如依據病人之特殊設計或解決之道),因而 提高修補手術之後之功效及舒適程度;(ii)免除手術醫生於 某些具體實施例需要在手術中測量欲修補的缺損的需求; (in)免除手術醫生於植入手術過程中成形材料的需求;(i幻 提供基於骨絡、軟骨或組織影像、或基於手術中探查技術 is而提供評估修補材料曲率或形狀之方法;⑺提供使用極少 骨質存量流失(或某些情況下毫無骨質存量流失)之修補關 即方法;以及(Vi)改良手術後關節的一致性。 如此此處說明可更精準齧合缺損(例如植入部位),因而 提供改良之關節修補之關節修補材料之設計及使用。 2〇 j. —如熟諳技藝人士已知,說明一種植入物其為喪置式關 即植入物、軟骨缺損隨形植入物、軟骨投影植入物及/或軟 Θ下月路隨形植人物。植入物有—上表面及—下表面。上 表面係與關節的第-關節面相對,而下表面係於關節的第 二關節面相對;此外其中上表面或下表面中之至少-者具 1231755 有三維形狀,其可實質上匹配第一關節面及第二關節面之 一的形狀。植入物適合安放於任何關節,包括膝、髖、肩、 肘、腕、指、趾及踝。植入物之上表面及下表面典型具有 三維形狀,其實質上匹配至少一關節面的形狀,植入物毗 5 鄰上表面、以及植入物毗鄰關節面之下表面。植入物係設 計成具有病人軟骨缺損之厚度或其部分厚度,典型為65% 至 99.9%。 植入物可由多種適當材料製造,該等材料包括生物相 容材料、金屬、金屬合金、生物活性材料、聚合物等。此 10 外植入物可由多種材料製造,包括塗層。 此外植入物具有附著於關節的機構。適當附著機構包 括脊、栓、銷、橫桿、齒及凸部。其它穩定關節的機構例 如脊、脣、及增厚件等也可設置於全部周面或部分周面。 植入物也可設計成有兩個或兩個以上的組成元件。此 15 等組成元件依據預定功能決定,可一體成形、不可分割成 形、互連成形以及獨立成形。於多重組成元件之情況下, 接觸關節之組成元件可設計成以滑動或旋轉或二者的組合 結合關節。另外,接觸關節之組成元件可固定於關節。任 何其它組成元件可與該元件所接合的任何其它組成元件一 20 體成形、不可分割成形、互連成形以及獨立成形。 植入物之各個組成元件或植入物本身沿其周邊或周長 形成之形狀為圓形、橢圓形、卵形、腎臟形、實質圓形、 實質橢圓形、實質卵形及實質腎臟形。此外,植入物之各 個組成元件或植入物本身具有之截面形狀可為球形、半球 12 1231755 形、非球形、凸面、凹面、實質凸面及實質凹面形狀。 植入物之設計為可使用ίο厘米或以下的切開進行植 入。此外,植入物係設計成可回復關節的移動範圍至正常 關節移動範圍之80-99.9%。 5 關節或其任何組成元件可有多種形狀,讓植入物周邊 比植入物中部厚度較厚。另外,植入物或任一種組成元件 可設計成植入物中部之厚度大於周邊厚度。由多個方向觀 視植入物,例如前部、後部、外側部及中部觀視,植入物 或其任何組成元件具有沿裝置後部之厚度係等於或大於植 10 入物之外側部、中部及前部中至少一者之厚度。另外,植 入物或其任何組成元件具有沿裝置後部之厚度係等於或小 於植入物之外側部、中部及前部中至少一者之厚度。但另 一具體實施例中,植入物或其任何組成元件具有沿裝置中 部之厚度係等於或小於植入物之前部、後部及外側部中至 15 少一者之厚度。另一具體實施例中,植入物或其任何組成 元件具有沿裝置中部之厚度係等於或大於植入物之前部、 後部及外側部中至少一者之厚度。 使用後述植入物修補關節之程序包括下述步驟,藉關 節鏡植入一植入物,該植入物具有一上表面及一下表面’ 20 其中該上表面或下表面中之至少一者具有實質上匹配該關 節面形狀之三維形狀。可於植入之前分析影像。典型影像 為MRI、CT、X光或其組合。 根據本發明之植入物之製造方法包括:測定一或多個 關節之關節面之三維形狀;以及製造一植入物其具有一上 13 1231755 表面及一下表面,其中該上表 衣面及该下表面係與關節的第 一關節面及第二關節面相對,w总% 乂及進一步其中該上表面或 下表面中之至少一者係實質匹 、 配°亥關郎面之三維形狀。 5 15 此外,本發明提供以植入材料置換部分(例如患病區面 積及/或略大於患病區面積)關節(例如軟骨及/或骨路)之新 穎裝置及方法,此處該^財與周_構餘織之至少 -面達成解聽合《狀抑合,且⑽關節活動性達 到關節正常活動範圍之㈣9.9%。此外,該植人物可忍受 於移動過程施加於M上高達卿謂力。當裝置及/或方法 包括關聯下方關節骨的元件時,本發明也提供骨襲元件 可與軟骨下骨達成解㈣正或接近㈣對正。本發明可以 單一切口準備植人位置。此等裝置可為嵌置式。裝置可為 早一元件、雙重元件或具有複數個元件。 本發明方法包含下列步驟:(a)測量預期植入位置之— 維或多維(例如厚度及/或曲率及/或尺寸),或測量環繞該期 望位置之區域維度;以及⑻提供軟骨置換或材料其係隨形 =步驟⑷所得測量值。就某些方面而言,步驟⑻包含測定 環繞期望植人位置之軟骨厚度,以及測定環繞期望植入位 置之軟骨曲率。另外步驟(a)可包含測量期望植人位置之尺 寸’及測量環繞期望植人位置之軟骨曲率;或測量環繞期 望位置之軟骨厚度,測量期望植入位置尺寸,以及測=環 繞期望植人位置之軟骨曲率;或重建於期望植人位置之健 康軟骨表面形狀;或測量期望植入位置尺寸,及/或測量於 期望植入位置或期望植入位置周圍之軟骨下骨曲率或幾何 20 1231755 形狀。此外,可測量於植入位置之剩餘軟骨厚度、曲率或 表面幾何形狀,且可與周圍軟骨之厚度曲率或表面幾何形 狀作比較。此種比較可用來更準確導出軟骨置換或材料的 形狀。 5立置換材料維度可於手術中測量後選擇,例如可使用超 2 MRI、CT掃描、χ光染料所得χ光影像及螢光影像等 =技術糊量。機_頭(具有或不具有造影能力)可用於 、、維度探頭例如為超音波探頭、雷射、光學探頭、 凹口探頭以及可變形材料。 1〇 —或多種可植人裝置包括三維本體。於膝關節,植入 物可用於-腔(單腔)或多腔(多腔)。於膝關節植人物之形狀 非為橢圓,反而係遵循關節軟骨、軟骨下骨及/或關節内結 冓的_維成何形狀。植入物具有一對相對表面。植入物之 f表面之輪廓匹配或實f上匹配下方軟骨及/或骨輪廊。而 15雜入物之相對表面輪廓形成匹配關節面之表面。例如相 對面表面可使«組化凸起來最佳化該表面供與關節匹 配。此外,相對表面可使用圓化界面連結。界面也可延伸 超出關即面。本發明之植入物可自我膨脹且適合藉關節鏡 插入。 袁置之各表面尺寸無須均勻。於任何指定點所取跨一 軸長度〇沿該軸為可變。同理,跨第二轴(垂直於第 一軸)長 度犯也沿該軸為可變。沿第—軸之任何〇長度與沿第二轴 的4何D長度之比可具有適合欲續正的肉體幾何之任何比 值,此比值為熟諳技藝人士所了解。 15 1231755 10 15 如熟諳技藝人士已知,此處所述任何可植入的關節屬 復物包含複數個(例如兩片或兩片以上)本體組成元件,各元 件可接合(例如滑動式接合)及/或可分開而未悖離本發明之 範圍。例如兩片式元件可裝設於各元件,該元件有一面之 輪廓係隨形於(部分或實質隨形於)下方軟骨及/或骨。若干 具體實施财,可接合之元件機面為彎曲。曲率經=擇 為類似該關節至少-關節面之曲率或為該關節面之鏡像曲 率。其它具體實施例中,可接合之元件之相對面為平坦。 其它具體實施财’可接合之元件之相對面為平坦與脊曲 的組合。可接合的元件相對面也可*規則。此種情況下, 較佳係設計成至少於一或多個位置彼此匹配。 此處所述任-種方法中,置換材料可經選擇(例如選自 原有的修齡統存庫)。如此修婦财於手㈣、手術中 或手術後製造。此外’於此處所述任―種方法,修補材料 也可使用業界已知之適當技術成形,於手術前、手術中或 ^術後成形。成職術包括m動、或機器成形; 使用機械純’包括研磨、雷射_、射頻祕、擠壓、 射出、模製壓縮成形及/或切削技術等成形。最後,植入物 =用一:伽生物活性材料如藥物、細胞、非細胞材料、 柰理作用劑、生物作用劑等。 ❹… 转’該方法包含植入 物根據此搞述任—财料備之料修 植入物典型係藉關節鏡植入, '、广 τ透過相封小的切開執行。 本發明灿供-種決定關節面曲率之方法,該方法包 20 1231755 含下述步驟,於手術中使用機械探頭或手術機械導航系統 測量關節面曲率。關節面包含軟骨及/或軟骨下骨。機械探 頭(具有或不具有造影能力)包括例如超音波探頭、雷射、機 械臂(例如鈦FARO臂)、光學探頭及/或可變形材料或裝置。 5 乡種卫具絲輔助裂置的植人。二具為導件,及輔助 相對於關節面以最佳方式定位裝置。用於該裝置之工具及 導件之没汁係由適合特定關節之裝置設計中導出。工具可 包括試驗植入物或手術工具其部分或實質隨形於植入部位 或關節腔。 10 此處所述任一種修補系統或贗復物(例如外表面)可包 含聚合物料或液態金屬。聚合物料可附著於金屬或金屬合 聚:物料可射出成形,且可自我硬化,或當暴露於二 學⑽、能束、光源、超音波及其它時硬化。此外,此處所 述任一種系統或屑復物適合經由軟骨置換材料外表面的開 進行/主射(例如外表面之一開口止於骨表面之複數個開 )月水’尼、治療物質及/或其它生物活性物質可經開口注 射若干具體實施例中,需要加壓注射骨水泥至關節面或 軟月下Θ或骨髓,俾達成骨水泥穿透部分植入部位。此外, 歧所述任_種修補系統戒贗復物可固定於骨髓或固定於 20軟月下骨本身。一或多種固定延伸件(例如栓等)可延伸貫穿 骨及/或骨髓。 若干具體實施例中,軟骨置換系統可被植入,而未侵 犯权Θ下骨,或只有少數松或錨延伸入或延伸貫穿軟骨下 骨。此項技術之優點為町避免未來植入物的「移居」以及 17 1231755 骨質溶解,結果導致關節不一致、或植入物鬆脫、或其它 併發症。 如熟諳技藝人士已知,適當關節包括膝、肩、髖、脊 椎、椎肩盤、肘·、踝、腕、指、腕骨與掌骨間關節、中腳 5關節及前腳關節等。此處所述技術同樣非僅限於人類關 節,也可延伸至任何哺乳動物關節。 此等及其它本發明之具體實施例對熟諳技藝人士鑑於 此處揭示將顯然自明。 圖式簡單說明 1〇 第1A®為根據本發明’評估需要修補之關節之方法之 方塊圖,其中於接納選用之植入物之前,既有關節面未經 改變或實質未經改變。第_為根據本發明,評估需要修 補之關節之方法之方塊圖,其中於設計適合達成修補之植 入物之前,既有關節面未經改變或實質未經改變。 15 第2圖為遠端股骨關節軟骨之三維厚度圖之再現。三維 厚度圖例如可有超音波、CT_RIf料產生。軟骨内部之 深色孔指示全厚度軟骨流失區。 第3A圖顯示同心設置光圈之帕西多圓盤範例。第3b圖 顯不投影於具有固定曲率表面之帕西多圓盤範例。 2〇 帛4圖顯示同心光圈(帕西多圓盤)投影於各個股骨課所 侍之反射,驗證表面輪廓變化對反射圓之影響。 第5圖顯示不規則彎曲面之二維加色碼之地形圖範例。 第6圖顯示不規則彎曲面之三維加色碼之地形圖範例。 第7A-B圖為根據本發明,評估需要置換關節之方法之 18 1231755 方塊圖,其中原有關節面於接納植入物之前經改變。 第8A圖為適合植入膝關節之脛骨岡之本發明關節植入 物之透視圖。第8B圖為第8A圖植入物之頂視圖。第^圖為 第8B圖之植入物沿第犯圖之視線以所取之剖面圖。第犯 5圖為第_沿視線D.D所取之剖面圖。第犯圖為第帽沿 視線E-E所取之剖面圖。第8F圖為第8A圖之植入物之側視 圖。第8G圖為第8A圖之植入物顯示植入後沿平行於矢狀平 面之平面所取之剖面圖。第8H圖為第8A圖之植入物顯示植 入後沿平行於冠狀平面之平面所取之剖面圖。第81圖為第 10 8A圖之植入物顯示植入後沿平行於軸向平面之平面所取之 剖面圖。第8J圖顯示於正中(朝向脛骨岡邊緣)及向前及向後 延伸接近骨之略大的植入物。第8K圖為第8A圖之關節植入 物之另一具體實施例之側視圖,顯示一錨。第乩圖為第8A 圖之關節植入物之另一具體實施例之底視圖,顯示一錨。 15 第9A及9B圖為適合用於股骨髁之關節植入物由下表 面及上表面觀視分別所得之透視圖。第9c圖為第9A圖植入 物之側視圖。第9D圖為植入物之下表面視圖;第9£圖為植 入物之上表面視圖,以及第9F圖為植入物之剖面圖。第9G 圖為適合用於二股骨髁之關節植入物上表面之視圖。第9H 20圖為第9G圖之植入物之透視側視圖。 第10A圖為髖臼之側視圖。第10B圖為近端股骨之旋轉 視圖。第10C圖為髖關節植入物之剖面圖,顯示實質上恆定 半徑。 第10D圖為類似第i〇c圖之植入物之剖面圖,具有圓化 1231755 邊緣及非對稱半徑。 第11A圖為具有元件延伸入股骨頭小窩之植入物之剖 面圖。其它平面圖顯示其它平面圖,第ΠΒ圖顯示植入物為 半球形’第11C圖顯示為部分半球形及第11E>圖顯示為轨 5形。第11E圖為具有輪輻配置之植入物之具體實施例。 第12A圖為植入物之剖面圖,有一元件延伸入髖臼小 窩。第12B-E圖顯示多種透視圖,其中該植入物為半球形、 部分半球形、執形及輪輻狀。 第13A圖為雙元件式「活動軸承」植入物之剖面圖,顯 儀 1〇示二件式組成及光滑匹配面。第13B_F圖為平面圖,顯示具 有半求之元件,單一半球有一軌或執狀外部元件(亦即 於一維為半球形,但其它各維並非半球形),單-半球具有 軌形内K構,單_半球具有輪輕狀内部元件,以及單一 半球具有輪輕狀外部元件。 15第13G’為雙元件式植人物之另-具體實_,此處 外部元件之内表φ有—結節其接合内部元件外表面之凹 部。也顯不其它變化。 第14A圖為植人物之另—具體實施例,植人物有一元件 延伸入股骨頭小离。第14B圖及第14C圖顯示剖面圖具體實 20施例,此處元件之-形成一半球,而第二元件則否。 第15A圖為雙元件式「活動軸承」植入物之剖面圖,具 有一元件延伸人競臼小窩。第15B及15C圖顯示剖面圖,此 處元件之一形成半球,而第二元件則否。 第16A圖為雙元件式「活動軸承」植入物之剖面圖。第 20 1231755 16B-D圖為三元件式「活動軸承」植入物之剖面圖,其具有 一或多個元件形成半球,而至少另一元件則否。^八 第17A圖為雙元件式「活動轴承」植入物之剖面圖,具 有-元件延伸入髖臼小窩。第17B及17c圖顯示剖面圖,^ 5處元件之一形成半球,而第二元件則否。 第18A圖為雙元件式「活動軸承」植入物之剖面圖,具 有一元件延伸入髖臼小窩。第18B圖為頂視圖,顯示第i8a 圖所示元件頂端四翅片延伸入髖臼小窩内部於髖臼元件頂 部。 10 帛19A圖為雙元件式「活動軸承」植入物之剖面圖,具 有一元件延伸入股骨頭小窩。第19B圖為雙元件式固定植入 物之剖面圖。 第20A圖為具有不等半徑及厚度之供競關節用之植入 物之剖面圖。第2〇B圖為具有不等半徑及厚度之供競關節用 15域人物之剖面圖。第胤圖為具有不等半徑及厚度之供親 關節用之植入物之剖面圖。第20D圖為髖關節用之植入物之 剖面圖,具有脣向下及向上延伸。 第21A圖為制節之骨質結構之前視圖,例如鎖骨、肩 狎、關節寫、肩峰、缘突及肱骨。第21B圖為置放於肢^ 與關節寫間之關節成形裝置之視圖。第加圖為關節成形裝 置之斜向前視剖面圖,具有料面實#_㈣骨抑 狀,以及關節窩面實質隨形於關節窩形狀。第2m圖為關節 成形裝置之軸向剖面圖,具有肢骨面實質隨形於肢骨^ 狀’以及關節窩面實質隨形於關節窩形狀。第21£圖肩關節 21 丄231755 之斜向前視圖,顯示關節 4 即秦^及上下關節窩脣。第21F圖為 5 10 15 20 圖為關節成形裝置之斜二:骨及前後麵脊。第21G 形於胜骨頭形狀,以及面圖’具有肱骨面實質隨 高胥形狀。軸吻隨侧M及關節 骨面實質隨形於胜骨^置之軸向剖面圖,具有肢 節寓及關節离胥形狀。第21二及關節寫面實質隨形於關 剖面圖,#_ 圖為關節成形裝置之斜向前視 面實質面實f隨形於胜骨頭形狀,以及關節寫 向貫質_於關節窩形 伸且提供關節_穩定。第2、:胥其係向上及/或向下延 面圖,具有肱骨面 & 圖為關節成形裝置之軸向剖 實質隨形於關:窩形:二形於肱骨頭形狀’以及關節窩面 且提供關節窩的穩定顯7^脣其係向前及/或向後延伸 節成形裝置之斜向二21K圖為雙树式「活動軸承」關 骨頭形狀,面圖’具有肱骨面實質隨形於肢 第机围為m實質隨形於關《形狀。 剖面圖,具有耿骨面實質二動:承」關節成形裝置之軸向 面實質隨形於關節窩 ^㈣骨頭形狀’以及關節窩 承」關節成形裝置^另、第圖為雙元件式「活動軸 骨頭形狀,以及關r 視圖,具有肱骨面實質隨形於肱 於第一元件表面上有/實貝h形於關節窩形狀。該裝置 俾促進關節的移動。固、、°即,其匹配第二元件表面之凹部 第21N圖騎it件式「 前視剖面圖。第210 、 /勤轴承J關節成形裝置之斜向 圖為雙70件式厂活動轴承」關節成形裝 22 U31755 斜向則視剖面圖。第2lp及q圖為第21〇圖所示雙重活 動轴承裝置之另一 ★ ,、體實施例之剖面圖。 應秦第22圖為通過肘關節之斜向縱視圖,顯示遠端肱骨、 5 10 15 20 h突及橈骨頭。也顯示軟骨表面。 t $23A圖為通過腕關節之縱視圖,顯示遠端橈骨、尺 、卜乂及右干腕骨其有—關節成形系統就位。第23b圖為通 ^關即之縱視圖,顯示遠端燒骨、尺骨、以及若干腕骨 圖 關節成形系統就位。第23C圖為通過腕關節之縱視 乂衾I貝不遠端繞骨、尺骨、以及若干腕骨其有一關節成形 為適合用於腕骨之雙元件式「活動轴承」 /成形裝置之縱剖面圖。第顶圖為另—雙元件式關節成 t裝置之縱剖面圖’本例不含脣。第23F圖為雙元件式「活 動軸承」關節成形裳置之縱剖面圖。 $24圖為通過手指之矢狀視圖。關節成形裝置顯示為 插置於掌㈣與近《骨基部間。, 第25A圖為通過踝關節之矢狀視圖,顯示遠端脛骨、距 骨及跟骨及其它骨,其有一關節成形系統就位。第25b圖為 通過踩關節之冠狀視圖,顯示遠端脛骨、遠端腓骨及距骨。 顯示一關節成形裝置插置於遠端脛骨與距骨圓頂間。第25^ 圖為通過躁關節之矢狀視圖,顯示遠端脛骨、距骨及跟骨 及其它骨。也顯示軟骨面。一關節成形裝置顯示為插置於 遠端脛骨與距骨圓頂間。第25D圖為通過踝關節之冠狀視 圖,顯示遠端脛骨、遠端腓骨及距骨。顯示一關節成妒妒 置插置於遠端脛骨與距骨圓頂間。 23 1231755 第26圖為通過腳趾之矢狀視圖。關節成形裝置顯示為 插置於掌骨頭與近端趾骨基部間。, 第2 7 A - D圖為將本發明裝置植入目標關節採用之各方 法步驟之方塊圖。 5 第28圖為植入第8L圖所示裝置時適合使用之植入導件 工具之平面圖。 第29A及29B圖為植入第9B圖所示裝置時適合使用之 植入導件工具之平面圖。 【實施方式;1 10 較佳實施例之詳細說明 後文說明係讓熟諳技藝人士可了解及利用本發明。此 處所述具體實施例之多項修改對熟諳技藝人士顯然易知, 此處所述概略原理可未悖離如隨附之申請專利範圍界定之 本發明之精髓及範圍,此處所述概略原理可應用至其它具 15體實施例與應用用途。如此,本發明絕非意圖囿限於所示 具體實施例’反而係符合此處揭不原理及特色之最廣義範 圍。至完整了解此處揭示之本發明需要的程度,本案引述 之全部已核發的專利案、專利公告案及專利申請案之說明 書及附圖以引用方式併入此處。 20 如業界人士已知,除非另行指示,否則本發明係採用 於業界技巧範圍内之X光造影與處理、X光斷層合成、超音 波包括A掃描、B掃描及C掃描、電腦斷層術(CT掃描)、磁 振造影(MRI)、光内聚斷層掃描術、單光子發射斷層掃描術 (SPECT)及正子發射斷層掃描術(PET)等習知技術。此等技 24 1231755 術於參考文獻有完整解說,在此無需說明。例如參考X光結 構測定:使用指南,第2版,Stout及Jensen編輯,1989年, 約輪威力父子公司出版;身體CT :使用辦法,Slone編輯, 1999年,麥克羅西爾出版;X光診斷:醫師辦法,Lam編輯, 5 1998年史賓基凡雷(Springer-Verlag)出版;以及牙科放射 學·了解X光影像,LaetitiaBrocklebank編輯,1997年,牛 津大學出版社出版。 I·關節之雙重或多重表面評估 本發明允許醫師評估且治療關節缺損,該關節缺損係 來自於例如關節病、軟骨退化、骨關節炎、血清陽性及血 清陰性關節炎、骨受傷、軟骨受傷、創傷及/或由於使用過 10 15 20 度或老化造成的退化。感興趣之區域尺寸、容積及形狀可 -包括缺損的軟骨區,但較佳也包括包圍軟骨缺損之軟骨 分。此外,感興趣區域之尺寸、容積及形狀包括軟 骨下骨、骨髓及其它關節結構例如半月板,帶及肌鍵。 、,第1Α圖為流程圖顯示醫師評估關節採行的各項步驟。 •r先,醫師獲得目標關節1〇之測量值。獲得測量值之步驟 可經由拍攝關節影像達成。若有所需該步驟可重仙來獲 得複數個影像,俾更進—步精緻化關節評估過程。一旦; =練得量值,該資訊衫產生接受評估之目 ^關^模式表㈣。此種模式表示可呈地形圖或影像形 ^括實式呈現可為—維、二維或三維。模式呈現可 二=。若有所需可形成多於一種模式”。無論為 …模式心後形成的模式或二者皆可使用。於產生關節 25 1231755 之模式呈現30後,醫師可於修正後的條件選擇性產生目標 關節之投影模式呈現40。再度若有所需或若屬期望,此步 驟也可重複41。使用關節之地形條件與關節投影影像間之 差異,醫師隨後選擇-種關節植人物5G其適合達成矯正後 之關節解剖。如業界人士了解,選擇過程50可於需要時重 複51,來達成預定結果。 如熟6曰技藝人士已知,醫師可由產生目標關節之模式 呈現步驟30直接前進至選擇適當關節置換植人物之步驟 10 .如箭頭32指示。此外,於選擇適當_置換植入物5〇 後,可以串列方式或並列方式重複獲得目標關節測量值 目標關節之模式呈觸、以及產生投影模式辦 步驟,如流程24、25、26所示。 驟。首春^ .、…丨、酋岬汗估關節時採行的涉 15 先,醫師獲得目標關節測量值1G。獲得測量值之斗 =拍攝關節影像達成。若有所需此步驟可重複u; =個影像,俾進-步精緻關節評估過程。,: 已經取侍需要的測量值,該資 —谱師 關節的模u錢。此種評估之目標 20 式。關節之模式呈現可為:形圖或影像形 若屬期望可重複處㈣。模式呈若有所需或 關節之模式呈現3。後,醫師可選^實體模式。於評估 橋正之條件下之投影模式呈現4生目標關節於經過 適5達成罐正後關節解剖之關節植入 26 1231755 物52,可視需要而經常性重複設計過程53來達成預定之植 入物設計。醫師也可評估是否提供額外結構例如脣、栓或 錨來提升植入物於目標關節的效能。 如熟諳技藝人士已知,醫師可由產生目標關節模式呈 5現步驟30直接跳至設計適當關節置換植入物步驟52,如箭 頭38所示。類似於上示流程,於設計適當關節置換植入物 52之後,可串列或並列重複獲得目標關節測量值步驟丨〇、 產生目標關節模式呈現步驟30、以及產生投影模式步驟 40,如流程42、43、44所示。 i° 制之或設計之關節植人物可達成與財關節面之解 别齧合或接近解剖齧合,同時呈現匹配面給相對關節面來 再現天然關節解剖。此種情況下,關節面可經評估,預定 所付關即面也可經評估。此項技術特別可用於未固定於骨 之植入物。 15 帛2_圖5兒明遠端股骨之關節軟骨之三維厚度圖的彩色 再現。三維厚度圖例如可由超音波、CT或MRI資料產生。
軟資物質内部的暗孔指示喪失全厚度軟骨區。由三維厚度 圖玎測定軟骨損傷大小及形狀。 X 如熟諳技藝人士已知,可使用任一種適當技術獲得尺 20寸、曲率及/或厚度測量值。例如利用下列技術可獲得— 維、二維及/或三維測量值,使用適當機械手段、雷射裝置、 電磁或光學追蹤系統、模具、施用於關節面上 「記憶表面輪廒 ^ ^ ^ 、 」之材料及/或一或多種造影技術。測量值 玎以^ ^又襲^方式及/或於手術中(例如使用探頭或其它手 27 1231755 面上任何 修補裝置 術裝置)得知。如熟諳技藝人士已知,依據於關節 特定位置,欲矯正的軟骨及/或骨損傷深度而定,P 厚度可於任一點改變。 A.造影技術 如熟諳技藝人士已知,適合用於測量患 流失區域厚度及/或曲率(如軟骨曲率及/或骨曲率 之造影技術包括X光、磁振造影(MRI)、電腦_層掃描、, 也稱作電職向斷層術或CAT)、光㈣料層術、 10 PET、超音波造影技術、及光學造影技術。(也參考細衫 月21日公告之Alexander等人之國際專利公告案 02/220M ; 2002年4月16日核發給τ麵f等人之美國專利 6,373,250 ;以及Vandeberg等人(2〇〇2年)放射學您 430-436)。對比劑或其它對比加強劑也可使用任何投二途徑 例如靜脈注射、關節内注射等使用。 μ " 15 某些具體實_巾,CT或MRI絲評估任何組織骨軟 骨及其中之任何缺損,例如關節病變或患病關節區來獲得 有關軟骨下骨或軟骨退化資訊,以及提供有關損傷區域的 形悲或生化或生物機械資訊。特別例如裂開等變化、軟骨 部分厚度或全部厚度流失,以及殘餘軟骨内部信號改變可 20使用-或多種此等方法侧。有關.基本通原理與技術的討 論,參考MRI基本原理與應用,第2版,Mark Α·阶〇〜^及 Richard C· Semelka,威力里斯公司(1999年)。有關MRI之討 論包括習知T1及T2加權旋轉回波造影、梯度回應回波(gre) 造影、磁化移轉對比(MTC)造影、快速旋轉回波(fse)造影、 28 1231755 對比增強造影、快速獲得鬆弛增強(RARE)造影、梯度回波 獲得穩態(grass)造影,以及驅動平衡傅立葉轉換(DEFT) 造影來獲得有關軟骨資訊請參考Alexander等人之wo 5 10 15 ⑸此於較佳具體實施例中,所得測量值係基於 如Alexander等人之WO 02/22014所述於關節獲得之三维 影像、或二維影像集合最終獲得三維資訊。可獲得單獨軟 骨、或組合軟骨移動類型例如屈曲_伸展、平移及/或旋轉之 二維、三維影像或映射圖。三維影像包括移動類型、二面 或多面相對關節面之接觸點、接觸區段、以及關節移動期 間該接觸點及接觸區段之移動資訊。二維及三維影像包括 關節軟骨之生物組成資訊。此外,造影技術可隨著時間的 經過比對,來職修婦料之較及類狀更新資气。 此處所述任-種造影褒置也可於手術中使用(例如也拍2下ί)例如使用手持超音歧/或光學铜來於手術中 拍攝關節面影像。 Β•手術中測量 02/22014
另外或此外可於„鏡手術相放㈣節切開術 W間獲得患病財區妹”失 20
厚度及/或軟骨或骨曲率測量值 際接觸關節面之一或多區。 τ之如並未涉 义置,以及產生表面地形圖之裝 r a ⑺add0)圓盤及雷射干涉 (仁非限制性加 參考聰年⑽日 發給wooh等人之美國專 29 1231755 6,057,927 ; 1996年6月 4 日核發給Yamane等人之5,523,843 ; 1998年12月8日核發給Sarver等人之5,847,804以及1997年11 月4日核發給Fujeda之5,684,562)。 5 15 20 第3A圖說明具有同心排列光圈之帕西多圓盤。帕西多 圓盤同心陣列投射有明確界限的而具有不等半徑的光圈, 可以雷射或透過光纖輸送的白光產生。帕西多圓盤可附接 至内視鏡裝置(或附接至任何探頭例如手持式探頭),讓光圈 可投射於關節面上。第顯示帕西多圓盤投影於固定曲 率表面範例。可使[❹部造影攝影機(例如附接至裝置 上)來捕捉光圈的反射。使賴學分析來測定表面曲率。而 率可於皿視社呈現出軟骨表面標有色碼的地形圖。此 外,地形圖之數學模式可用來測定理想表面地形,置換, 分析區域的任何軟骨缺損。然後此種經 ^ 面也呈現在監視器上,例如第2圖 ㈣里心表 用來選擇置崎料或再生材料的表面曲f技圖’該圖 所二顯示由同"光圈(帕西多圓盤)投射至各個股骨課 件、射,驗證表面輪廓變化對反射光圈的影響。 同理,雷射干涉計也可附接於 a 小型感測器可附接於内視鏡裝置,;^置末端。此外’ 來測定軟骨表面或骨曲率,產生軟 _干涉計量術 ,析相圖(波前)。_率於監視:二:圖 ▼有色碼的地形圖。此外 J為軟月表面之 分析_任何軟_骨:損 30 1231755 想表面可於監視器上觀視,且可用來選㈣ 量技ί諳技藝人士了解可採用其它軟骨表面曲率之光學測 Τ而未悖離本發明之範圍。例如可產 圖,如第5圖及第6圖所示。 圓次% =使用機械裝置(例如探頭)來作手術中測量,例如< 15 20
到被/I如凝膠、模具、任何硬化材料(例如可維持變形直 :、、、、冷卻或以其它方式触為止之㈣)。例如參考 年5月2日頒予Dickson等人之w〇 〇2/3431〇。例如可變 形凝膠施用於股骨髁。凝膠之朝向股魏該側可獲得股贵 踩表面輪权貞像凹刻。然後該貞像_絲決定缺損尺 寸、缺損深度、以及缺損或毗鄰缺損的關節面曲率。此項 資訊用來選擇治療,例如關節面修補系統。另一例中,玎 轭用硬化材料至關節面,例如股骨髁或脛骨岡。硬化材料 留在關節面上直到硬化為止。然後由關節面移開硬化材 料硬化材料的面對關節面該側可獲得關節面的負像凹 d 然後该負像凹刻用來決定缺損尺寸、缺損深度、以及 缺損位置及鄰近缺損之關節面曲率。然後此項資訊用於治 療例如關節面修補系統。若干具體實施例中,硬化系統< 留在原位,且構成實際關節面修補系統。 若干具體實施例令,可變形材料包含複數個活動機械 元件。當朝向感興趣的表面加遷時,各個元件可朝向相反 方向推進,而其推進(變形)程度係對應於感興趣表面之曲 率。該裝置包栝煞車機構,因此該等元件可維持於隨形於 31 1231755 幸人月及/或月表面位置。然後由病人身體移開該農置且分析 曲率另外,個別活動元件包括記號,指示於指^點的變 形量及/或變形程度。使用攝影機於手術中造影裝置,影像 儲存用來分析曲率資訊。適當標記包括(但非限制性)實際線 5性測量(公制或英制)、不同色彩對應於不同變形量,及/或 相同色彩的不同色度或色調對應不同變形量。活動元件的 位移也可使用電子裝置測定。 其它於手術中測量軟骨及軟骨下骨之裝置包括例如超 音波探頭。超音波探頭較佳為手持式,可施用於軟骨^ 10測量軟骨及/或軟骨下骨曲率。此外,可評估軟骨缺損尺 寸,以及測定關節軟骨厚度。此種超音波測量可以八模、、B 模或c模獲得。若獲得續測量值,則操作員典型係以不同 的探頭方向作測量,例如中間偏侧方向及前後方向,俾導 出尺寸、曲率及厚度之三維評估。 15 熟諳技藝人士使用光學探頭、雷射干涉計量術、機械 及超音波探頭了解不同的探頭設計皆屬可能。探頭較佳為 手持式。某些具體實施财,翻或至少部分翻(典型為 接觸組織部分)可為無®。錢性可㈣賴蓋達成,例如 類似1999年2月25日公告之Lang之W0 99/〇8598A1揭示之 20 無菌蓋。 使用造影試驗及/或手術中測量對關節軟骨或軟骨下 骨曲率分析’可用來测定患病軟骨區大小或軟骨流失大 小。例如該曲率可能於軟骨流失區遽然改變。此種曲率的 遽然改變或突然改變可用來偵測患病軟骨邊界或軟骨缺損 32 1231755 邊界。 ιι·關節之單一表面評估 現在參考第7A圖,提供方塊圖,顯示進行關節之單一 表面評估之各步驟。如同第1A及1B圖,獲得目標關節之影 5 像或測量值60。隨後以該測量值來辅助選擇適當裝置來矯 正缺損70。測量步驟或造影步驟可視需要重複來輔助辨識 修補缺損的最適當裝置80。一旦完成測量,選用一種裝置 來矯正缺損90。本例中,只複製關節之一表面。此項技術 特別可用於植入物包括可將植入物固定於骨之機構之例。 10 如此,植入物至少有一表面其複製關節面,植入物至少有 第二表面係與欲修補的受損關節之關節面或骨之部分或全 部連通。 如熟諳技藝人士已知,醫師可由測量關節缺損步驟70 直接前進至選擇修補缺損的適當裝置步驟90,如箭頭38指 15 示。此外若有所需獲得目標關節測量值60、測量關節缺損 70、識別適合修補缺損之裝置80、選擇修補缺損之裝置90 等任一步驟或全部步驟皆可重複一或多次61、71、81、91。 類似上示流程,於選定修補缺損的裝置90後,可串列 或並列重複獲得目標關節測量值60、測量關節缺損70、識 20 別適合修補缺損之裝置80等步驟,如流程65、66、67所示。 第7B圖顯示另一種方法,提供方塊圖顯示對關節進行 單一表面評估之各步驟。如同第1A及1B圖,獲得目標關節 之影像或測量值60。隨後進行測量來辅助選擇矯正缺損之 適當裝置70。測量步驟或造影步驟可視需要重複71,俾輔 33 1231755 助識別修補缺損之最適當裝置80。 造出矯正缺損用之裝置92。 如热諸技藏 古技〜 醫師可由測量關節缺損步驟70 直接錢至製造修補缺損之裝置92,如: 若有所需獲得目θ 项妁私不。此外 .^ 軚關即測置值60、測量關節缺損70 丨 適合修補缺損之裝㈣、製造修補缺損之裝置H 驟或全部步驟皆可重複-或多次61、71、81 93專任一步 Μ = Ϊ不流程’於製造修補缺損的裝置92後,可串列 目標關節測量值6〇、測量關節缺損7。、識 別適2雜損之裝㈣等步驟,如流㈣、77、78所示。 电化Γ種方法可用來輔助於單—表面評估期間將關節模 、、且化。例如使用軟骨厚度 節敕骨…^ 4曲革貝訊’可對任-點形成關即軟二及/或軟骨下骨表面模式。關節之模式呈現可為一 、、維或-、維可包括實體模式。實體模式可表示關節 内部的有限區域、或模式可涵蓋整個關節。 特別於膝關節,實體模式可只涵蓋正中或外側股骨 蘇、-股骨媒及凹口區、正中腔骨岡、外側脛骨岡、整個 脛月岡正中體骨、外側鑛骨、整個骸骨或整個關節。勒 月患病區所在位置例如可使用三維座標线三維歐幾里待 2〇距離轉換(如Alexander等人於w〇 〇2/22〇14所述卿別⑽ 轉換測定。 旦 已經作測量,則製 10 15
藉此方式,可準確測定欲修補的缺損尺寸。顯然部分 但非全部缺損包括小於整個軟骨。測量正常軟骨厚度,或 測量環繞-或多處軟骨缺損而只有輕度患病軟骨厚度。厚 34 1231755 度測量值可於單點或多點獲得。取愈多測量值,則可愈精 緻且愈準確地作測定。如此,例如可於2點、4-6點、7-10 點、多於10點或於整個其餘軟骨長度作測量。可獲得二維 及三維測量值。此外一旦測定缺損大小,則可選擇適當治 5 療(例如植入物或植入物置換區等於或略大於覆蓋一或多 關節面之患病軟骨),讓儘可能保留健康的周圍組織。 另外,可測量關節面或下方骨骼曲率來設計及/或成形 修補材料。此種情況下可測量剩餘軟骨厚度以及關節面曲 率來設計及/或成形修補材料。另外可測量軟骨下骨曲率, 1〇所得測量值用來設計、製造、選擇及/或成形軟骨置換材料。 HI.關節裝置 本裝置為贗復物。贗復物形式或裝置形式係經由將現 有軟骨及/或骨骼輪廓投影來有效模擬自然關節結構之各 方面。該裝置可實質上回復關節的正常對正狀態,及/或對 15其匹配之相對關節面至原先或正常關節面提供一致或實質 一致的表面。此外由於裝置之隨形表面提供解剖齧合或接 近解剖齧合既有的關節面,因此可實質上免除關節的進一 步退化。裝S的插入係透過小型(例如3厘米至5厘米)的切開 進行,且無需作裝置的骨胳切除或機械固定。但如熟諸技 藝人士瞭解,可提供額外結構例如橫桿、翅片、检、齒(如 角錐形—角形、類球形或圓錐形凸起)或銷,此等額外結 構可增強裝置更有效座落於關節面上的能力。骨贊或其它 干擾裝置置放的結構容易被去除。襄置經由以解剔#合或 接近解剖齧合占據關節腔,裝置可改善關節穩定性,回復 35 1231755 關節的正常或接近正常的機械對正狀態。 此處所示裝置之精確尺寸可藉下述方式_ 分析特定個體之影像,設計—種裝置,其實質^传且 該個體的_解剖(軟f及/或骨),㈣如前=係隨形於 關節面幾何。如此可對各別個體量身訂製本;置=二的 本發明多錢裝置可為適合用於最錢襲性之手術植 入且無需夕骼切^裝置。該裝置可固定於骨,但非必要。 例如於膝时,該裝置可為單-腔室,換言 · w半月板尋常所在腔室。天然半月板可維持於原位,或可;; 邛去除或部分去除’視情況而定。於尋常情況下,已經被 撕開的天然半月板被去除,若有所需受損區可經修整。另 外,也可去除全部剩餘半月板。此項去除也可經由 用來插 入裝置的該切Π進行。對多種植人物而言切除可藉關節鏡 I5手術進订,所作切開長1-15厘米,但較佳長卜8厘米且更佳 長1-4厘米。 此處所述裝置於同一平面(例如前後平面或正中外㈣ 籲 平面或上下平面或斜向平面)或於多個平面可有各種曲率 及半徑。藉此方式可成形關節面修補系統,來達成植入物 2〇與植入部位間的解剖對正或接近解剖對正。此項設計不僅 允許不同程度的凹凸,同時也允許於主要為凸面形狀具有 凹部’反之亦然。匹配欲修補關節之植入物表面具有各種 幾何形狀,該幾何形狀係隨欲修補關節面之實體損傷而改 變。但热諸技藝人士可基於典型損傷類型製作植入物。也 36 1231755 此Γ損傷發生前關節結構之正常輪廓製作植入物。 變製作如植入物也可根據關節移動期間對側面形狀的改 旋轉、平移此植二物考慮於關節屈曲、伸展、外展、内收、 變。 m動及其組合期間-或多個關節面形狀的改 3料裝置較佳為可邊緣平移且可自我取中。如此 位置來配合關節的自缺移略為移動或適當改變其 、、西注lL , …、移動。但裝置不會於關節内部自由 10 關節移動期間當由第-位置平移至第二位置 達:關郎的移動逆轉時’袭置容易返回其原先位置而到 μ ::1置二結果裝置不會於裝置所在腔室内側漸進「蠕 蓰腔室一側。表面之可變幾何形狀連同植入物之略 為非對稱形狀,可輔助植入物的自我取中行為。 15 可維節面上維持穩定。例如於膝關節’裝置 物之略而股骨鍊係於褒置上自由移動。植入 種於—關::緊密叫關節*’可輔助達成此 20 附著機構二移動若有所需可選擇性藉 _構也允許二構此 ,平移。該機構進—步可將裝置固定於關節=於另一方 許袭置傾斜。適當附著機構包括聲、给、鎖j同時允 凸部。此等機構之組配狀態可彼此 此,捍、齒及 構可為角雄形、三㈣、類球形:此非平行。機 屯或在何可達成其 37 1231755 效果之形狀。可裝設一或客 拖嫌 個附著機構。若設置多於一個 機構,則該機構可覆蓋裝置 設額外穩定機構,例如脊、2絲面或部分表面。可裝 周面。 背及增厚件沿全部周面或部分 5 10 15 20 狀^物形狀也結合其所在關節形狀,例如脛骨棘部形 與脛骨棘的隨形’例如於脛骨棘基部的隨形,有 助於相對於脛骨岡來穩定植入物。 選用之植人物N度或輪廓可改變植人物相對於關節之 =承載⑽力此外,可轉植人物高度而考慮骨或關節 、、、°構之解剖上的未對正。❹卜對此處教示之任—種植入物 而s,當有動帶鬆弛情況時,可調整植人物高度、輪廓或 、它尺寸來允許_變緊而改良關節功能。如此較佳實質 並未干擾骨之軸向對正。典贱,㈣可忍受施加於移動 中關節之高達100%剪力。 本發明植入物典型可回復關節的移動性達該特定個體 天然關節移動性之99.90/0。例如以膝關節為例,整個關節活 動係於(TC至MOt之範圍。目前之解決之道典型達成關節 活動的回復小於99.9%,而本發明之植入物典型可將移動範 圍回復至該病人正常移動範圍之95_99 9〇/。。 付自國豕標準與技術協會(http://ovrt.nist.gov) 健康 男性手及臂關節移動範圍說明於表1。 38 1231755 表1 手關節及臂關節之移動範圍 關節移動 範圍(度)平均值 範圍(度)標準差 腕屈曲 90 12 腕伸展 90 13 腕内收 27 9 腕外展 47 7 前臂後旋 113 22 前臂前旋 77 24 肘屈曲 142 10 肩屈曲 188 12 肩伸展 61 14 肩内收 48 9 肩外展 134 17 得自國家標準與技術協會(http://ovrt.nist.gov)之健康 5 男性腳及腿關節移動範圍說明於表2。 39 1231755 表2 腳關節及腿關節之移動範圍 關節移動 範圍(度)平均值 範圍(度)標準差 踝屈曲 35 7 踝伸展 38 12 踝内收 24 9 踝外展 23 7 膝屈曲-站 113 13 膝屈曲-跪 159 9 膝屈曲-俯 125 10 膝旋轉-正中 35 12 膝旋轉-外側 43 12 髖屈曲 113 13 髖内收 31 12 髖外展 53 12 髖旋轉-坐(正中) 31 9 髖旋轉-坐(外側) 30 9 髖旋轉-俯(正中) 39 10 髖旋轉-俯(外側) 34 10 本發明植入物典型可對任何關節之表1及2所示之一或 5 多項測量值之移動範圍回復至該病人之該項測量值正常移 動範圍之95-99.9%。 容後詳述,此處教示之任一種裝置可以任一種方式製 造,因此該裝置於嵌入之後可膨脹。膨脹可為自動膨脹、 半自動膨脹或使用者調整時膨脹。 10 現在說明根據本發明之範圍及教示之關節植入物之說 明例。 40 1231755 A.膝 第8A圖顯不適合植入膝關節之脛骨岡之本發明之關節 植入物100之透視圖。如第8A圖所示,植入物係使用雙重表 面評估產生,如前文就第丨八及⑺圖說明。 5 植入物100有個上表面1〇2及下表面104及周緣106。上 表面102係成形為其形成可供接納對側關節面之匹配面;於 本例為部分凹面來接納股骨。凹面可為可變之凹面,因而 對對側關節面提供近似其矯正關節之匹配面的表面。下表 面104具有凸面,該凸面匹配或接近匹配關節之腔骨岡,因 1〇而形成於脛骨岡的解剖齧合或接近解剖餐合。依據腔骨岡 形狀而定,下表面可為部分凸面。如此下表面1〇4呈現一表 面給腔骨岡,該表面齧合於原有表面内部。如熟諸技藝人 士已知,下表面104之凸面無需為完美凸面。反而下表面1〇4 15可能由凸件以及凹件組成來齧合脛骨岡之原有表面。如此 该表面為大致多變化之凹凸面。 第8B圖顯示第8A圖之關節植入物之頂視圖。如第犯圖 所示,植入物外形108可細長。細長形狀可呈多種形狀,包 括橢圓、準橢圓、跑道等形狀。但須了解外部尺寸典型為 不規則因而無法形成真正的幾何橢圓。如熟請技藝人士 知,植入物之真正外形係依據欲矯正的關節缺陷本質而改 變。如此長度L對寬度W之比例如可於〇5至15間變化,更 特別由0.25變化至2.0。如第8B圖進一步顯示,當沿植入物
寬度之各點,跨植入物100軸向長度可改變。例如如第8B 圖所示关L3。 41 1231755 現在參考第8C-E圖,顯示第犯圖所示植入物沿線 C C D-D及E-E之剖面圖。植入物分別具有厚度tl、t2&t3。 如該剖面圖所示,植入物厚度順著其長度L而改變。於植入 物1〇〇任何特定點的實際厚度係依據欲置換之軟骨及/或骨 5厚度以及欲複製的關節匹配面之函數而改變。此外,於植 入物100長度或寬度之任_點之輪廓係依據欲置換之軟骨 及/或骨之函數而改變。 第8F圖為第8A圖植入物100之侧視圖。本例中,植入 物1〇〇於第-端高度hl係與植入物於第二端高度h2不同。此 10外上緣1G8具有總斜率於向下方向。但如圖所示,上緣1〇8 之實際斜率係順著其長度而改變,某些情況下可為正斜 率。此外下緣110具有總斜率於向下方向。但如圖所示,下 緣110之實際斜率係順著其長度而改變,某些情況下可為正 斜率。 15 第8G圖為沿身體矢狀平面所取之剖面圖,顯示植入物 100植入膝關節120内部,植入物丨〇〇係位於脛骨岡122上, 股骨124係停靠於植入物1〇〇之上表面1〇2上。第8]3圖為沿身 體冠狀平面所取之剖面圖,顯示植入物1〇〇植入膝關節 120。由本視圖顯然易知,植入物1〇〇係定位成齧合於上關 20節面124内部。如熟諳技藝人士已知,視需要,關節面可為 正中小面或外側小面。 第8A圖為沿身體軸向平面所取之剖面圖,顯示植入物 100植入膝關節120,顯示由上方所取之頂視圖。第8J圖為 另一具體實施例之剖面圖,此處植入物略大故植入物延伸 42 1231755 而較為接近正中骨,換言之朝向脛骨岡邊緣接近,以及向 月’J及向後延伸。 第8K圖為本發明植入物ι〇〇之另一具體實施例之剖面 圖。本具體實施例中,下表面104包括關節錨112。如本具 5體實施例所示,關節錨成形為凸部、龍骨或直立件,其由 植入物100下表面104延伸,凸進例如關節骨内。此外如第 8L圖所不,關節錯112具有橫桿114,由底部透視,關節錯 112具有十字或「X」形外觀。如熟諳技藝人士已知,關節 錨112可呈多種其它形式,同時仍然達成可於關節提供植入 10物100之較咼穩定性之目的。此等形式包括(但非限制性) 銷、泡、珠等。此外若有所需可設置一或多個關節錨112。 關節成形術可有兩個或兩個以上的組成元件,一元件 匹配脛骨面,而另一元件實質上匹配股骨元件。二元件具 有平坦相對面。另外,相對面可彎曲。曲率可反映於關節 15活動期間的脛骨形狀、股骨形狀、及半月板形狀及其組合。 現在參照第9A-F圖,顯示適合提供第8A圖之植入物之 相對關節面之植入物。此種植入物可矯正股骨内面(亦即股 骨匹配例如脛骨岡部分)的缺陷,且可單獨使用,換言之於 股骨單獨使用,或組合另一關節修補裝置使用。第9A圖顯 20示具有彎曲匹配面152以及凸面關節I»比鄰面154之植入物 150。關節毗鄰面154無需成形為解剖齧合或接近解剖齧合 股骨,原因在於設置銷156來輔助植入物與骨的連結。此種 情況下,錨156顯示為帶有凹口頭之栓。凹口可輔助固定於 骨之過程。但不含凹口之栓也可使用,以及栓可具有其它 43 1231755 組配狀態來輔助固定過程。栓及植入物其它部分可具有多 孔塗層。植入物可插入而未使用骨水泥、或使用骨水泥了 植入物可設計成田比鄰軟骨下骨,換言之實質上遵循軟骨下 骨的輪廓。其優點為除了安置栓狀外m除任何骨, 5 因而可顯著保留骨質存量。 第9G及9H圖說明適合提供第8A圖植入物之相對面之 植入物151,其中該植入物意圖覆蓋股骨鍊,可選擇性地與 第8A圖之一或多個植入物相對。 關節成形系統可設計成反映出腔骨形狀及/或股骨形 10狀之各方面。脛骨形狀及股骨形狀包括軟骨及骨或任一 者。此外,植入物形狀也包括其它關節結構部分或全部組 成元件,例如半月板。半月板可壓縮特別於走路或荷重時 可壓縮。因此理由故,植入物可設計成考慮荷重時或肉體 活動時半月板的壓縮而結合半月板形狀之各方面。例如, 15植入物下表面可設計成匹配脛骨岡形狀包括軟骨或骨或二 者形狀。植入物上表面可為脛骨關節面(特別為未被半月板 覆蓋區)及半月板之複合形狀。如此裝置之其它各方面可反 映半月板南度。考慮壓縮,此南度例如為未經壓縮之半月 板高度之20%、40%、60%或80%。 20 若干具體實施例中,反映半月板形狀之裝置外側可由 另一種材料且較佳為可壓縮材料製成。若選用可壓縮材 料,則較佳没a十成實負匹配半月板之壓縮性及生物機械表 現。整個裝置通常可由此種材料或非金屬材料製成。 半月板高度及形狀可於造影試驗直接測定。若部分或 44 1231755 全部半月板為陽性元件,則半月板高度及形狀可由對側關 節測量值導出,或使用其它可對半月板尺寸提供估值的關 節結構測量值導出。 另一具體實施例中,植入物上表面可根據股骨成形。 5該形狀較佳係由股骨相對於脛骨岡之移動類型導出,因而 考慮當股骨髁於脛骨及半月板上屈曲、伸展、旋轉、平移 及滑動時,股骨形狀及脛骨股骨接觸區之各項變化。 移動類型可使用任一種業界已知之目前測試或未來測 試方法測定,例如螢光鏡、MRI、步態分析或其組合。 10 B·髖 第10A圖為體之體白200之侧視圖。軟骨覆蓋區2〇2呈有 倒U字形。三放射狀軟骨區或髖臼小窩2〇4係位在軟骨覆蓋 區内部。第10B圖為近端股骨210之旋轉視圖。也顯示軟骨 覆蓋區202及股骨頭小窩206。 15 現在說明適合用於髖關節之植入物,第10C圖為用於髖 關節植入物220之剖面圖。此植入物之半徑1·沿長度之任一 點實質上為恆定。植入物半徑經選擇為近似植入物欲矯正 的股骨頭半徑,植入物半徑可測量至接合股骨頭之植入物 220内面。另外’植入物半徑係選定為近似髖臼半徑或其組 20合。植入物内面222半徑面對股骨,也匹配股骨半徑、或類 似體白半徑;植入物面對髖臼表面之半徑也匹配髖臼半徑 224或類似股骨半徑。 熟諸技藝人士了解髖臼之天然幾何形狀典型為非球 形由真球形形狀略為改變。視需要,植入物半徑可調整 45 1231755 為髖臼之變化半徑而提供昜 、料齧合。如域人物於上表面 及或下表面或二表面可為球形或非球形半徑。 第_圖為類似第10c圖所示,適合用於髋關節之植入 ^剖面圖’其特徵為具有圓化邊緣226。圓化邊緣226為 較佳’原因在料其使用時可避免植人物的鎖定,同時也 可最小化植入物可能造成的疼痛。 10 15 20 第UA圖為類似第⑽圖所示,適合用於髖之植入物 220之剖面圖’植入物具有—結節咖,結節23G延伸入股骨 碩小窩240於其内表面222。結節23〇可由植入細之相同 材料或與植人物其餘部分不同材料製成。具有結節23〇供接 合股骨頭小寓之植人物之優點為,結節230可用來約束植入 物220相對於股骨頭之移動(顯示於第圖)。如熟諳技藝 人士已知’結節23G有多種組酉己狀態,#植人而接合股骨頭 小窩時健可達成相同絲。顯衫種平關,提供植入 物為半球形、部分半球形或軌形之平面圖。其它形狀為業 界人士賴易知。此外,植人物邊緣可為圓化、可傾斜、 或任何可輔助植入物操作之尺寸。第UB-E圖顯示第11A圖 ^植入物之另—具體實施例,其中植人物為半球形、部 分半球形、執形及輪輻形。 第12A圖為適合用於競之植入物22〇之剖面圖,該植入 物有一凸部232延伸入髖臼小窩204内於其外表面224。凸部 3 )可由植人物220其餘部分之相同材料或不同材料製成。 凸初2可用來約束植入物相對於髖臼小窩之移動 。如熟諳 有人士已知,凸部232可呈多種組配狀態,而當接合髖臼 46 ^31755 小离時仍然達成相同效 形、部分半球形或執形或四岔 =二其提供半球 5 10 15 20 =藝人士顯_。此外,植::二= 次其匕可輔助植入物操作之尺寸。第细為®化、傾斜 所示之另—具體實施例, 圖』不第12A圖 球形、軌形及輪輻形。/、〜植人物為半球形、部分半 第13A圖為具有多種不 一 植入物功之剖面圖件「活動轴承」 件231。第-元件齧合__第—轉23G及第二元 ,合第一元件之外 有—千'月面。第二 發明之範®,鮮面有二镑面。未挣離本 個元件可為半球形。一元:=皆屬可能。例如各 =:_形、軌形或_頂::: 不第13A圖所示植入物 & ㈣顯 物至少有-元件為半球形、部:=實::其中該植入 ^刀+球形、執形及輪輻形。 圖。植入:圖為雙組成元件式「活_承」植人物之剖面 物具有一第一元件及一第二元件。第一 :第二元件内部。第二元件餐合於第一元件外表面。。 处所不’-結節設置於第二元件上,其係齧合於第— —卩如热叫技藝人士已知,雖然於圖中未顯示, 節可位於第m,,合於第二元件之-孔内, ^離本發明之範圍。如所示其它固定機構於第一元科 一件或―元件上亦屬可能。多種平面圖之組配狀態 可此(雖^圖中未顯不)且未悖離本發明之關。例如名 47 1231755 可為半球形。一個元件可為半球形,而另一元件為部分半 球形、較短半球形、軌形或四岔圓頂形。 第14A圖為另一雙元件式「活動軸承」植入物240之剖 面圖,該植入物有一結節246延伸入股骨頭小窩206内部。 5雙元件式植入物240具有第一元件242及第二元件244。結節 246係设置於第二元件244。如前文就第11C圖所示,結節246 用來約束植入物240之第二元件244相對於股骨頭之移動。 面對髖臼之第一元件242可相對於面對股骨頭之第二元件 244自由移動。如熟諳技藝人士 了解,雙元件式植入物可組 10 配成接合第二元件245表面之第一元件243表面具有相等長 度’或實質上相等長度。如此形成匹配之組成元件其實質 上彼此齧合。另外,元件可組配成讓一元件比另一元件更 短’如第14B圖及第14C圖所示。第15A圖為另一雙元件式 活動轴承」植入物240之剖面圖,有一凸部248延伸入競 15 臼小窩内部。雙元件式植入物240具有第一元件242及第二 元件244。凸部248設置於第一元件242上。凸部248可用來 約束植入物240之第一元件242相對於髖臼之移動。面對股 骨頭之第二元件244可相對於面對髖臼之第一元件242自由 移動。如前文就第13A圖說明,第15A圖所示植入物也可組 2〇 配成一元件比另一元件更短,如第15B及15C圖所示。 第16A圖為二元件式「活動軸承」植入物25〇之剖面圖。 面對髖臼之第一元件252有一結節253延伸入髖臼小窩2〇4 内。卩。如前文討論,結節253可用來約束植入物25〇相對於 髖臼之移動。面對股骨頭之第二元件254有一凸部255延伸 48 1231755 入股骨頭小窩206内部。如前文就單元件及雙元件式植入物 討論,凸部255可用來侷限植入物250第二元件254相對於股 骨頭之移動。第三元件256係插置於另二元件間,可介於二 元件間自由移動。如熟諳技藝人士已知,第三元件Mg可插 5置於第一元件252與第二元件254間,故其長度比第一元件 252或第一元件254更短(如第16B圖所示),或比第一元件 252或第二元件254更長(如第16C及16D圖所示)。同理,第 三元件長度可比第一元件252或第二元件254更長。 第17A圖為類似上示之另一雙元件式「活動軸承」植入 10物240之剖面圖。本具體實施例中,裝設錨來固定第一元件 242於髖臼小窩204。所示錨係呈一或多個銷262形式。面對 體白之元件係使用二實質平行之栓而固定至親臼。面對股 骨頭之第二元件244可於面對髖臼之第一元件242上自由移 動。如同先别具體實施例,第一元件242相對於第二元件244 15之長度可改變。第及17C圖顯示其它剖面圖,此處第一 元件比第二元件更大,以及相反情況。如同先前各具體實 施例,未悖離本發明之範圍於平面圖之多種組配狀態皆屬 可能。例如各個元件可為半球形。一元件可為半球形,而 另一元件可為部分半球形、較短半球形、軌形或四岔圓頂 20 形。 第18A圖為另一雙元件式「活動軸承」植入物24〇之剖 面圖,其具有一錨延伸入髖臼小窩204内部。面對髖臼之錨 係呈凸起形式且有一或多個翅片264。面對股骨頭之第二元 件244可於面對髖臼之第一元件242上自由移動。第18B圖為 49 1231755 第18 A圖植入物之頂視圖,顯示於該元件頂端有四翅片 (264、264,、264”、264,,,)延伸入髖白元件頂端之髖臼小窩 内。翅片可為銳利或實質上銳利(如圖所示),或可具有圓化 緣。 5 第19A圖為另一種雙元件式「活動軸承」植入物240之 剖面圖,具有錨266可延伸入股骨頭小窩206内。所示具體 實施例中,面對股骨頭之第二元件244係使用一或多個實質 平行之栓(顯示為268、268,)而固定至股骨頭。第一元件242 面對髖臼,如前一具體實施例所示,且可於面對股骨頭之 10 該元件上自由移動。 第19B圖為另一雙元件式「活動軸承」植入物24〇之剖 面圖。本具體實施例中,雙重元件24〇為固定。如此處所示, 股骨兀件使用三個栓266或其它附著機構而附著於股骨 頭。若有所需栓數目可大於3或小於3。較佳使用此種設計, 15 20 軟月下月轉完好’只有检之進人點除外。㈣元件使用 翅片264或_之附著裝置如栓(如第i7A圖所示)而附著於 髖臼。附著機構可成形為有元件可延伸人體臼小窩之骨。 权月下讀佳維持完好,只有附著裝置之進人點除外。 第_圖為用於髖關節之具有不同半徑(Γι、Γ2、Γ3)及厚 3)之植入物470之剖面圖;此處半徑^外夫巧以 ^又1 t2#t3。如熟諳技藝人士已知,可取半徑及厚度 測量值來說明該點’但可未悻離本發明之範圍使用 / 測量值。此外’其它半徑及厚度雜合也可使 用,例如心叫、—外及㈣响。其它組 50 1231755 δ為熟諳技蔹人本駐姑 "士頌然易知。如第20Α圖所示 度'比一或多周邊部Pl、P2更厚。 植入物47^為料體㈣具有不料徑及厚度之另一種 植入物470之剖面圖。太# 5厚度㈣物ρ Λ ^具有厚獻, 々 (Pl,P2)之一或多個厚度丨〗、t2更薄。 植入物47 W為用於競㈣具有不料徑及厚度之另一種 植入物470之剖面圖。 厚度⑽周邊部之第二邊:實=:,中部。’ 之第 L之厚度η更薄,而比周邊部 弟一周邊舳P2之厚度t2更厚。 =圖為競關節用另—植人物柳之剖面圖,其且有 /夕胥_定延伸件延伸於下概/或上方v脣可竹 成延伸超出關節面,例如延伸入非 ^ 於周圍關節解剖。脣可捭徂頁負上了奴形 15 20 H仏額外穩定。此項設計組合雙元 及一凡件以及「活動軸承」設計。 如熟,日技藝人士顯然易知,第ig糊所示植入物 、化狀於或多維可為半圓形(例如180度),但非必要 :。此處若植入物於各維度皆為半圓。 :半球⑽將-球以通過球心之平面切割所得之二 勿开>狀非為+球形。其形狀可於上表面或下表面之任 或—表面為非球形來配合鑛白。例如若有多於一個者 貝可抓用二維形狀的組合。例如第一元 件非為半球等。 干&第二元 此外’雖然此等元件顯示為有一至三個元件,但須 51 1231755 解各個元件可進一步修改成為複數個彼此接合元件,而未 悖離本發明之範圍。 熟諸技藝人士進一步了解弟10-20圖教不之設計考慮 可用於設計其它關節如膝、踝、肩、肘及腕使用之植入物。 5 為了避免混淆本發明,並未顯示此處教示植入物之全部可 能組配狀態。 C·肩 第21A圖為肩關節300之骨質結構之前視圖,例如鎖骨 302、肩胛304、關節窩306、肩峰308、喙突310及肱骨312。 10 軟骨覆蓋區314、316以斜線表示。 第21B圖為置於肱骨頭313與關節窩306間之關節成形 裝置320之視圖。關節成形裝置320可具有類似第4A-4R圖所 示設計特徵之一,例如複數個元件、活動轴承設計、附著 以及非附著設計、不同厚度及曲率設計、隨形於肱骨頭313 15或關節窩3〇6或二者之設計、隨形於關節軟骨及/或軟骨下 骨之设計、具有胥或穩定用元件之設計。 第21C圖為關節成形裝置320斜向前視剖面圖,裝置320 具有肱骨接觸面322,其至少部分隨形於肱骨頭313及具有 關節窩接觸面324其至少部分隨形於關節窩3〇6。 20 第圖為關節成形裝置520之軸向剖面圖,裝置320 具有肱月接觸面322,其至少部分隨形於肱骨頭313及具有 關節窩接觸面324其至少部分隨形於關節窩3〇6。 第為肩關節之斜向前視圖’顯示關節軟骨316以 及上及内關節窩胥306,、306”。第21F圖為肩關節之轴向視 52 1231755 圖顯示關郎軟骨316及前及後關節窩胥3〇7,、307,,。 第21G圖為關節成形裝置320斜向前視剖面圖,裝置32〇 具有肢骨接觸面322,其至少部分隨形於胜骨頭犯及具有 關節窩接觸面324其至少部分隨料關節嵩3〇6及關節寓胥 5 (3〇6’、3〇6’’)之形狀。第21H圖為第21G圖所示關節成形裝 置320之軸向剖面圖。如上示,提供肱骨接觸面322,其係 隨形於肱骨頭313形狀;以及提供關節窩接觸面324,其係 隨形於關節窩306及關節窩胥之形狀。 第211圖為關節成形裝置340斜向前視剖面圖,裝置34〇 10具有肱骨接觸面342,其至少部分隨形於肱骨頭313及具有 關節窩接觸面344其至少部分隨形於關節窩3〇6。可設置一 或多個凸部或脣346、346,其係於上方及/或下方延伸。脣可 組配成提供於關節窩上的穩定。第21J圖為第2Π圖所示關節 成形裝置340之軸向剖面圖,裝置34〇具有肱骨接觸面342, 15其至少部分隨形於肱骨頭313及具有關節窩接觸面344其至 少部分隨形於關節窩306。可設置一或多胥346,,、346,,,, 其係向前及/或向後延伸來提供於關節窩3〇6之穩定。 第21K圖為雙元件式「活動軸承」關節成形裝置35〇之 斜向前視剖面圖,裝置350具有第一元件351之肱骨接觸面 20 354,其係隨形於至少部分肱骨頭;以及第二元件353之關 節窩接觸面354,其係隨形於至少部分關節窩形狀。如熟諳 技藝人士已知’二關節植入面之半徑可選擇為匹配或實質 上匹配肱骨半徑或關節窩半徑或二者。此外,植入物可具 有接觸面’其實質上或視需要儘可能隨形於肱骨或關節 53 1231755 窩,俾達成預定矯正效果及功能效果。此外,二關節植入 物表面356、358之旋轉中心可選擇為實質上匹配肱骨頭旋 轉中心。如熟諳技藝人士已知,二關節植入物表面356、358 具有包括平坦面之任一種形狀。 5 第21L圖為第21K圖所示雙元件式「活動軸承」關節成 形裝置之軸向剖面圖。胜骨接觸面352係組配成如本具體實 施例所示,讓其實質隨形於肱骨頭313形狀;具體實施例之 關節窩接觸面354係組配成實質上隨形於關節窩306形狀。 二關節植入物表面半徑係選擇為匹配肱骨、關節禽或二者 10 表面。此外,二關節植入物表面之旋轉中心可選擇為實質 上匹配肱骨頭旋轉中心。第21M圖為另一具體實施例,顯 示植入物具有一凹部於一元件、以及一珠於第二元件。凹 部及珠之組配狀態可顛倒,讓其位在相反表面上,而未悖 離本發明之範圍。如眾所周知,所示珠及承窩配置可辅助 15植入物各元件相對於彼此之移動,但也可輔助防止各元件 於操作時非期望的移動。 第21N圖為雙元件式「活動軸承」關節成形植入物36〇 之另一具體實施例之斜向前視剖面圖。植入物36〇具有第一 元件362以及第二元件364。關節窩元件364組配成有二表 面。第一表面363係組配成可相對於第一元件362作關節活 動。第一表面363係組配成匹配關節窩3〇6。第二元件或關 節窩元件364係使用一或多個銷365而附著於關節寫。銷祕 係呈栓或翅片形式或其它適當組配形式,俾達成將關節嵩 轉364蚊於關節高之駭效果。栓或翅片可經膠黏、經 54 1231755 多孔塗覆或二者。同理, 膠黏多孔塗覆或二者。車之關即窩接觸面363可經 第加圖為雙二伸人軟骨下骨。 Η 一目棘奋 舌動軸承」關節成形裝置370之 _著機構斜向前視剖面圖。肢骨接觸科372係使 片構(如栓或翅片或如本觸示使⑽幻73)附著於 7=12。此等检、翅片、齒或銷釘可經膠黏經多孔塗覆 :=Γ:肱骨元件下表面也可經膠黏或經多孔塗覆 10 錐形 可延伸入二;:附著機構的本身(例如检、翅片或銷釘) ,月肖、翅片、齒或銷钉可為角錐形、圓 ,形、球形、管形或任—種凸起形狀,且可呈隨 組配形式於有組織的組配形式(例如成列)表面上。如此處 =:_之關節寓側有關節軟骨374。植入細設計 15 圖所二:::::7:軟骨下骨或二者。如第21Ρ及21Q 此平行。_可有交錯長度,且可組配成各翅片彼 如當中’植人㈣合用於軟組織損傷。例 全部妒典-衣時’植入物可具有延伸部覆蓋部分或 骨頭二碩上方。藉此方式,因旋轉機環帶撕裂,造絲 20變二=遷移不會導致胜骨頭與尖峰鎖骨關節的關節病 人物延伸病廢失能。反而胜骨頭上表面可與植 性。 y成關即,藉此避免尖峰鎖骨關節的象牙質變 D·肘 顯示遠端肱骨 第22圖為肘關節βοο之斜向縱視圖, 55 1231755 602、鷹嘴突604、及橈骨頭606。軟骨面分別顯示於603、 605、607。關節成形裝置620顯示為插置於遠端肱骨與尺骨 608及橈骨610之關節面間。關節成形裝置620具有就第 10-20圖所示裝置之類似設計特色,例如單一元件、雙重元 5 件、三重元件;活動軸承設計;附著及非附著設計;各種 厚度及曲率設計;隨形於肱骨或尺骨或橈骨或其組合設 計;隨形於關節軟骨及/或軟骨下骨設計;具有脣或元件供 穩定用之設計。但為了避免混淆本發明’對本關節並未顯 示本案教示之各項可能設計考慮變化。 10 E.腕 第23A圖為貫穿腕關節700之縱視圖,顯示遠端橈骨 702、尺骨704以及數個腕骨其形成腕列706(例如舟狀骨、 新月骨、三角骨、錘狀骨及鉤骨)。關節成形裝置720顯示 插置於遠端橈骨702、遠端尺骨704、及近端腕骨列之關節 15面、706,,、706,,,間。關節成形裝置720隨形於遠端橈 骨702、近端腕骨列706以及於本例中,隨形於三角形纖維 軟骨(虛線)708之形狀。 如熟諳技藝人士已知,關節成形裝置720具有就第 10-20圖所示裝置之類似設計特色,例如單一元件、雙重元 20 件、三重元件;活動轴承設計;附著(例如附著於遠端橈骨) 及非附著設計;各種厚度及曲率設計;隨形於肱骨或尺骨 或橈骨或其組合設計;關節軟骨及/或軟骨下骨設計也隨形 於其它關節結構例如三角形纖維軟骨;具有脣或元件供穩 定用之設計。 56 1231755 第23B圖為貫穿腕關節700之縱視圖,顯示遠端橈骨 702、尺骨704及若干腕骨706。關節成形裝置720顯示插置 於遠端燒骨702、遠端尺骨704及近端腕骨列706之關節面 706’、706’’、706’”間。關節成形裝置720係組配成其係隨 5 形於至少部分遠端橈骨7〇2、遠端尺骨704及近端腕骨列706 之形狀。 第23C圖為貫穿腕關節700之縱視圖,再度顯示遠端橈 骨702、尺骨704及若干腕骨706。關節成形裝置730顯示插 置於遠端橈骨702、遠端尺骨704及近端腕骨列706之關節面 10 706’、706”、706”’間。關節成形裝置730係顯示為實質隨 形於遠端橈骨702、近端腕骨列706及遠端尺骨704包括尺骨 莖710之形狀。胥732係沿遠端橈骨之正中以及遠端尺骨704 包括尺骨莖710之外側方向延伸;如此提供植入物相對於此 等骨為固定。一或多個脣732或其它適當組態之凸部可朝向 15關節任一骨之背側或掌側方向延伸。 第23D圖為雙元件式「活動軸承」關節成形裝置74〇之 縱視圖。裝置740具有第一元件742及第二元件744。各個元 件有一表面其與其它元件743、745之表面形成關節。二關 節植入物表面半徑經選擇為匹配橈骨7〇2或尺骨7〇4或腕骨 20 706或其組合半徑。此外,二關節植入物表面之旋轉中心可 選擇為匹配或近似關節700之旋轉中心。如熟諳技藝人士已 知,二關節植入物表面743、745具有任一種可輔助關節功 月匕之表面形狀,包括平坦面。注意近端元件之脣746、748 係沿正中以及沿外側延伸。脣也可朝向背側及掌側方向延 57 1231755 伸0 第23E圖為另一雙元件式「活動轴承」關節成形裝置· 之縱視圖,本例不含脣。裝置75〇具有第一元件乃2及第二 元件754。各個元件有—表面’其與其它元件、乃$之表 5面形成關節。由該剖關誠易知,第—元件關節面⑸之 長度比第二元件關節面755之長度更長。 第23F圖為雙元件式「活動轴承」關節成形裝置彻之 縱視圖。如所示’面對橈骨及尺骨之第一元件762係使用附 著機構或銷766而附著於此等骨。適當錯?66包括检,如本 1〇例所示包括銷釘及/或翅片(僅舉出數例)。如熟諸技藝人士 已知’裝置760之附著可限於只附著於—骨(例如附著於尺 骨或橈骨)。 F.手指 第24圖為通過手指8〇〇之矢狀面視圖。顯示關節成形裝 15置820,其係插置於掌骨頭802與近端指骨804基部間。關節 成形裝置820之一側822係隨形於掌骨頭802之形狀,於相對 侧824係隨形於近端指骨804基部形狀。關節成形裝置82〇具 有類似第10-20圖所示之設計特色,例如單一元件、雙重元 件、三重元件;活動軸承設計;附著(例如附著於掌骨頭或 20指骨基部)及非附著設計;各種厚度及曲率設計;隨形於近 端或遠端關節面或其組合設計;關節軟骨及/或軟骨下骨設 計也隨形於其它關節結構例如三角形纖維軟骨;具有脣或 元件供穩定用之設計。類似之設計也可用於後腳、中腳及 前腳包括足趾。 58 1231755 G·踝 第25A圖為貫穿踝關節900之失狀面視圖,顯示遠端脛 骨902、距骨904及跟骨906及其它骨。也顯示軟骨面。關節 成形裝置920顯示為插置於遠端脛骨902與距骨圓頂904, 5 間。本例中,關節成形系統920係隨形於距骨904形狀。如 熟諳技藝人士已知且如前文討論,裝置可隨形於軟骨或軟 骨下骨或二者形狀。關節成形裝置920可具有類似第10_20 圖所示及前文討論之設計特色,例如單一、雙重、三重元 件活動軸承設計、附著及非附著設計、可變厚度及曲率設 10 計、隨形於脛骨或距骨或腓骨或其組合形狀設計、隨形於 關節軟骨及/或軟骨下骨設計、具有脣或穩定目的元件之設 計。 第25B圖為通過踝關節900之冠狀面視圖,顯示遠端脛 骨902、遠端腓骨908、及距骨904。關節成形裝置930顯示 15 插置於遠端脛骨902與距骨圓頂904,間。本例中,關節成形 系統930顯示隨形於距骨9〇4之形狀。 第25C圖為通過踝關節900之矢狀面視圖,顯示遠端脛 骨902、距骨904及跟骨906及其它骨。也顯示軟骨面。關節 成形裝置940顯示插置於遠端脛骨902與距骨圓頂904,間。 20本例中,關節成形系統942之下表面實質隨形於距骨9〇4形 狀。上表面944實質隨形於遠端脛骨902及腓骨(9〇8,圖中 未顯示)之形狀。脣946顯示於下表面942且接合距骨904。 第25D圖為通過踝關節900之冠狀面視圖,顯示遠端腔 骨902、遠端腓骨908、及距骨904。關節成形裝置95〇顯示 59 1231755 插置於遠端脛骨902與距骨圓頂904,間。本例中,關節成形 糸統之下表面952係隨形於距骨904之形狀。上表面954係隨 形於遠端脛骨902及腓骨908之形狀。 H.趾 5 第26圖為通過趾1〇〇〇之矢狀面視圖。關節成形裝置 1020顯示插置於疏骨頭1002與近端趾骨1004基部間。關節 成形裝置1020顯示於第一面1022係隨形於疏骨頭之形狀, 於第二面1024係隨形於近端趾骨基部形狀。如熟諳技藝人 士已知,關節成形裝置具有類似第10-20圖所示之設計特 10 色,例如單一元件、雙重元件、三重元件;活動軸承設計; 附著(例如附著於疏骨頭或趾骨基部)及非附著設計;各種厚 度及曲率設計;隨形於近端或遠端關節面或其組合設計; 關節軟骨及/或軟骨下骨設計也隨形於其它關節結構例如 三角形纖維軟骨;具有脣或元件供穩定用之設計。類似之 15 設計也可用於後腳、中腳及前腳。 D.裝置之製造、組成及性質 前述裝置或任一種根據本發明之教示製造之裝置可由 多種業界已知之適當材料製備。 寬廣多種可用於本發明之實施例之材料包括(但非限 2〇 制性)塑膠、金屬、陶瓷、生物材料(例如膠原或其它胞外基 質材料)、羥基磷灰石、細胞(例如幹細胞、軟骨細胞等)、 或其組合。基於有關缺損及/或關節面及/或軟骨下骨所得資 訊(例如測量值),可選用適當材料。此外使用一或多種此處 所述技術,可製造具有曲率可齧合特定軟骨缺損之軟骨置 60 !231755 換材料或再生材料可遵循關節面的輪靡及形狀,且可匹配 周圍軟骨厚度。此外,使用此處所述一或多項技術,可成 ,即I置’其可齧合關節形狀’且可遵循關節面或其它 關節結構之輪廓及形狀。該材料包括任一種材料的組合, 5且較佳包括至少一種實質非撓曲性材料。 另 卜材料可具有硬度梯度。如此例如硬度梯度可由 表置中心朝向外緣遞減。如此製造—種有整錄性之裝 4可〜邛为或全部外側表面隨形於該表面。獲得一種 由材料製成的外表面,其可增進植入物匹配關節的能力。 另\於某些情況下可製造裝置,此處外表面之蕭耳硬度 值係高於内剖面之蕭耳硬度值。 ,裝置之外部硬度適合植入物於關節内部發揮功能。適 *硬度為热諳技藝人士顯然易知,包含_定範圍硬度。典 呈更度係就蕭耳硬度尺標作討論,可於工程等級塑膠至硬 15化鋼及鈦之範圍,較佳係於鋼、硬塑膠及陶竟等材料之业 型洛克威爾硬度尺標。由裝置期望具有高硬度,顯然易: 裝置之功能係與先前技術裝置之功能完全不同。本發明裝 置之目的係達成跨距效果來架橋二缺陷區。此外於複合變 化例’任何單_ (件(例如後述之生物活性材料元件)可比支 20 承材料柔軟。 同時合併使用之修補系統包括裝置可採用金屬及/或 聚合物材料。例如參考細年3月20日頒予Afriat#人之美 國專利第6,203,576號;2001年3月27日頒予Fell等人之 6,206,927 ;及扇1年11月27日頒予〇gk等人之6,322,谓及 61 1231755 其中引述之參考文獻。同理,發現多種金屬可用於本發明 之實施例,且可基於任一種標準選擇,例如基於提供預定 剛硬程度之彈性作選擇。適當金屬之非限制例包括銀、金、 翻、把、錶、銅、錫、錯、娣、絲、鋅、鈦、始、不鏽鋼、 5 鎳、鐵合金、鈷合金如衣吉羅伊(Elgiloy)、鈷-鉻-鎳合金及 MP35N為一種鎳-鈷-鉻-鉬合金、及尼提諾(Nitinol)為一種鎳 鈦合金、銘、锰、鐵、鈕、其它可形成多價金屬離子之金 屬,例如用來抑制植入基材接觸體液或身體組織時的鈣 化、及其組合。 10 適當合成聚合物包括(但非限制性)聚醯胺類(如尼 龍)、聚酯類、聚苯乙烯類、聚丙烯酸酯類、乙烯基聚合物 類(如聚乙烯、聚四氟乙烯、聚丙烯及聚氯乙烯)、聚碳酸酯 類、聚胺基甲酸酯類、聚二甲基矽氧烷類、乙酸纖維素、 聚甲基丙烯酸甲酯、聚醚醚酮類、聚醚酮酮、乙烯乙酸乙 15 烯酯類、聚颯類、硝基纖維素類、類似之共聚物及其混合 物。也可使用生物可吸收之合成聚合物例如葡萄聚糖、經 基乙基澱粉、明膠衍生物、聚乙烯基吡咯啶酮、聚乙烯醇、 聚[N-(2-羥基丙基)曱基丙烯醯胺]、聚(羥基酸類)、聚(ε -己内酯)、聚乳酸、聚乙醇酸、聚(二甲基乙醇酸)、聚(羥基 20 丁酸酯)及類似之共聚物。 共聚物可經由多種辦法之任一種製備,包括習知聚合 物加工方法。較佳辦法包括習知射出成形其適合用於製造 有顯著結構特色之聚合物元件;以及包括快速原型辦法例 如反應射出成形及立體印刷術。基質可藉物理磨蝕或化學 62 1231755 改變製作成為多孔來輔助金屬塗層之結合。 聚合物可注入模具内,該模具反映出關節面或其它關 節結構之各方面。 多於一種金屬及/或聚合物可彼此組合使用。也可使用 5 液態金屬。例如一或多種含液體基材可於一區或多區塗覆 以聚合物;或另外,一或多種含聚合物基材可於一或多區 塗覆以一或多種金屬。 裝置或其零組件可為多孔或經過多孔塗覆。多孔表面 元件可由多種材料包括金屬、陶瓷及聚合物等材料製成。 10表面元件又可藉多種手段牢固固定於由各種金屬製成的多 種結構中心。適當多孔塗層包括(但非限制性)金屬、陶究、 聚合物(例如生物中性彈性體如矽膠、聚對苯二甲酸伸乙酯 及/或其組合)或其組合。例如參考1971年9月20日核發給
Hahn之美國專利第3,605,123號;1974年4月23日核發給 I5 Tronzo之美國專利第3,808,606號;1974年10月29日核發給
Tronzo之美國專利第3,843,975號;核發給Smith之美國專利 第3,314,420號;1976年10月26曰核發給Scharchach之美國專 利第3,987,499號;及德國專利說明書2,3〇6,552。可有多於 一層塗覆層,各層可具有相同或相異之孔隙度。例如參考 20 1976年2月17日核發給Kahn等人之美國專利第3,938,198號。 塗層可使用粉狀聚合物包裹中心,加熱至硬化來形成 具有互連孔隙之内部網路之塗層。孔隙之蜿蜒(例如通過孔 隙路徑之長度對直徑測量值)對於評估此種塗層用於廣復 裝置是否可成功相當重要。例如參考1980年7月22曰核發給 63 1231755
Morris之美國專利第4,213,816號。多孔塗層可以粉末形式 施用,物件整體置於升高溫度,讓粉末黏合至基材。適當 聚合物塗層及/或粉末塗層之選擇可鑑於此處之教示及引 用之參考文獻,例如基於個別之炫體指數決定。 5 此處所述任一種裝置皆可包括一或多種生物材料,可 單獨或組合非生物材料使用。生物材料之非限制性實施例 包括細胞(例如胎兒軟骨細胞)、生物聚合物(例如膠原、彈 性蛋白、絲、角質、明膠、聚胺基酸、貓腸縫合線、多醣 類如纖維素及澱粉)、自體移植物、同種異體移植物、異種 10移植物等。參考1995年12月26日核發給siivka等人之美國專 利第5,478,739號;1998年12月1曰核發給Naughton等人之 5,842,477 ; 2001年9月4日核發給vibe-Hansen等人之 6,283,980 ;以及2002年2月4日核發給Salzmann等人之 6,365,405 〇 15 某些具體實施例中,裝置包括一或多個分開(但較佳可 接合)元件。例如二件式裝置包括二元件,此處各個元件包 括一匹配面。二元件可互鎖。當彼此匹配時,有外廓之表 面彼此相對’且形成一裝置其齧合於欲矯正之缺損内部, 來提供模擬或複製天然關節面之關節面。任何適當互鎖機 20 構皆可使用,包括可滑動(例如鍵槽)系統;互鎖鉤;珠與鍵 槽互鎖系統;凹槽與凸緣系統等。若干具體實施例中,可 接合之元件表面為彎曲。曲率可反映出一或多個關節結構。 其它具體實施例中,裝置之組配狀態於部署人關節0 部時改變。如此裝置可於初步組配狀態設計。當部署日寺, 64 1231755 裝置獲得與最初組配狀態不同的隨後組配狀態。例如裝置 可為多元件式裝置,於第一組態具有小型外廓或小型三維 形狀。而當部署時,外科醫生允許(或造成)裝置形成第二種 組態,該第二組態具有較大外廓或整體三維形狀。裝置可 5自動成形為其二次組態,或另外,可經操控例如藉機械手 段變成二次組態(例如展開裝置,或裝置之各元件相對於彼 此滑動,讓其獲得較大之第二組態)。此種具體實施例之優 點為只需要小型切口。裝置例如可以關節鏡方式部署。如 此獲得隨後組態可為自動、半自動或人工。 10 此處所述方法及組成物可只用來置換部分關節面,例 如關節面之患病軟骨區或喪失軟骨區。此等系統中,關節 面修補系統可没计成只置換患病軟骨或流失之軟骨區,或 可延伸超出患病軟骨或流失軟骨區,例如進入正常鄰近軟 骨3或5毫米。若干具體實施例中,贗復物只置換關節面(例 15如任何指定關節面,例如單一股骨髁等)小於約70%至 80%(或介於其間之任何數值”較佳小於約5〇%至7〇%(或介 於其間之任何數值),更佳小於約3〇%至5〇%(或介於其間之 任何數值),更佳小於約2〇%至3〇%(或介於其間之任何數 值),又更佳小於關節面之約20〇/〇。 20 E•另一種附著機構 如熟諳技藝人士已知,可裝設多種附著機構來附著植 入物於目標’内部。例如附著機構為設置於植入物底面 之錐形錐體女置於裝置底面,故其位於腔骨軟骨凹部 之底部。錐體可類似球形,錐體也可與植入物下表面例如 65 1231755 藉圓柱形元件分開。其它適合供附著之幾何形狀 拉 藝人士顯然易知。 夕-热暗技 半固定式附著機構之又另一範例為磁鐵,磁鐵置於下 方軟骨下骨層例如置於脛骨。另一磁鐵或磁性材料則埋設 5於或附著於裝置下表面,然後裝置利用第一磁鐵而維持= 位。如热諸技藝人士已知,可使用複數個關聯各表面之磁 鐵。此外,可使用磁鐵的組合,因而各表面有一或多個磁 鐵其具有第-磁極,以及一或多個磁鐵其具有第二磁極, 而接合位於相對表面之具有相反磁極之磁鐵。此種配置可 10用於需要防止裝置於關節内部旋轉,同時確保二表面間連 通之情況。 此種附著機構之又另一範例為螺絲或銷,其可插入位 於脛骨軟骨凹部底部的脛骨軟骨下骨内。農置可固定至螺 絲或錫’或有半固定設計,例如結合開槽,開槽於螺絲或 15 錨上方滑動。 植入物高度可經調整來駐_的未對正或轴向偏 差。例如於膝關節,關節高度可經調整來橋正内翻足或外 翻足畸形。此種橋正可使用關節及鄰近關節之轴向測量值 決定。例如赠之CMM轉料t重放祕㈣可用於 20 此項目的。 植入物厚度也可經選擇或經調整來橋正動帶的鬆他。 例如於膝關節,可選用略為較厚的植入物來考慮一或多個 十字勃帶或附屬勤帶的鬆弛或撕裂。植入物厚度的增加^ 為均勻或非均勻,例如主要位於周緣。外科醫師可於手術 66 1231755 中使用一或多個試驗性贗復物或實際植入物來測試何種植 入物厚度就關節及植入物的鬆弛可獲得最佳結果。 V·植入 此處所述裝置典型係植入關節缺損區。植入可以軟骨 5置換材料或再生材料仍然附著於底材或由底材去除進行。 任一種適當方法及裝置皆可用於植入,例如下列專利案所 述之裝置:2002年4月23日頒予Hangody等人之美國專利第 6,375,658號;2002年3 月 19 日頒予Torrie等人之6,358,253 ; 2〇〇1年12月11日頒予Hardwick等人之6,328,765 ;以及2001 10年3月22日公告至Cummings等人之國際公告案w〇 01/19254 。 15 20
植入物可使用關節鏡的輔助而插入。該裝置無需某 單L至及全膝關節成形術所採用的1 5厘米至如厘米切開 手術係於局部麻醉典型為硬膜外麻醉進行。可綁止企帶 肢之車又為近端部。含有欲修補之關節區使用無菌技術 遮蓋簾部。例如以膝關節為例,使用通管針,採用 ,關節鏡技術’於關節之前中方向及前外側方向形成兩伯 只J孔Μ即鏡經由外側該孔插人。關節鏡儀器經由 :插入。軟骨缺損可使用關節鏡觀察。軟骨缺損定位器 f於患病軟骨内部。探頭具有U字形,第―臂接觸關節 ::病軟骨區中心,U字形的第二臂留在關節外側。U字. t臂指示軟骨相對於皮纽置。手術醫㈣皮膚上 二月缺知位置。於缺損位置作出3厘米切開 。插入組織 開為,觀察缺損。 67 1231755 然後將植入物插入關節。植入物前方位置及後方位置 可加色碼。例如前栓標紅色及小字母「A」,後栓標綠色及 小字母「P」。同理’植入物正中方向標黃色及小字母「Μ」, 植入物外侧方向標示小字母「L」。 5 軟骨各區可如此處所述造影來偵測軟骨流失區及/或 患病軟骨區。可測定批鄰患病區之軟骨及軟骨下骨邊緣及 $狀。可決疋軟骨厚度。可決定半月板或其它關節結構形 狀。裝置之尺寸及形狀係基於前述一或多項測量值決定。 特別修補系統可(基於最佳匹配)選自一類具有不同尺寸及 10曲率範圍之既有預製植入物、或使用CAD/CAM技術依據客 戶需求或對病人量身訂製。依據客戶需求設計之植入物可 使用一或多種病人相依性參數而產生。病人相依性參數可 使用欲修補的病人關節之一或多項測量值獲得。此外,既 有的形狀存庫約有30種尺寸。如熟諳技藝人士已知,若有 15所需,存庫含有多於30種形狀或少於3〇種形狀,而未挣離 本發明之範圍。 特別欲將裝置植入髖關節,手術醫師可如前述作出小 切開。組織牵開器及其它常用於髖關節手術之手術器材^ 用來暴露出髖關節。隨後開啟關節囊。第二手術醫師拉Z 2〇股骨或腔骨,俾便開啟股骨頭與髖臼間之空間。進行手^ 之主要醫師將關節成形裝置插入關節内部。若有所+手術 術醫師可切開股骨頭韌帶,清創部分關節空間,俾去陕= 起的唇組織及軟骨襟翼。手術醫師也可選擇去除位、示凸
Jttj Γ〇Γ /L· «I- ^狀 1231755 另外,若關節成形系統係由可自行膨脹之材料(例如尼 提諾)製成,則外科醫師可藉標準或經修改之關節鏡辦法進 入體關節。然後將植入物經由同一開口或第二開口或另外 經由小切口輪送。植入物一旦位於關節内部則可膨脹而赛 5得其最終形狀。為了辅助可膨脹之植入物定位,可使用導 件或模具。導件或模具適合股骨關節面或髖臼關節面之三 維輪廓,且可置於植入物之預定位置。然後植入物順著導 件前進’或另外位於導件或模具内部之中空腔室前進。一 旦植入物已經到達其預定位置,則可移出導件或模具,留 10 下植入物於原位。 νι·裝置模具 本發明之另一具體實施例中,容器或孔可成形為選定 之規格,例如匹配特定個體所需材料,或形成多種尺寸之 修補備料及/或材料。容器尺寸及大小可使用得自關節以及 15彳于自軟骨缺損之厚度及曲率資訊設計。特別容器内側可遵 照選定之測量值成形,例如得自特定個體之軟骨缺損剛量 值。容器(模具⑽置換材料填補來形成欲植人之裝置。 模具可使用任-種適當技術形成,例如電腦裝置及自 動化技術形成,例如電腦辅助設計(CAD)及例如電腦輔助模 20式化(CAM)。由於所得材料通常係遵循容器内側輪靡 所得裳置最佳齧合缺損本身,因而有助於整合。 VII·植入導件及手術工具 前述模具也用來設計手術植入導件及工具,其至少有 一外表面係匹配或接近匹配下方關節面(骨及/或軟骨)輪 69 1231755 廓。若干具體實施例中,二或多個外表面匹配對應關節面。 工具全體形狀可為圓化、圓形、卵形、橢球體、彎曲或不 規則形狀。該形狀經選擇而匹配或包圍患病軟骨區、或略 大於患病軟骨區之面積。另外,工具可設計成略大於患病 5 軟骨區。工具可設計成涵蓋整個關節面。 可獲得一或多電子影像來提供物件座標,該座標界定 關節面及/或骨面及形狀。例如也可使用造影試驗如CT或 MRI掃描或直立載重放射性攝影來界定關節之生物機械 軸。此等物件座標用來成形裝置,例如使用CAD/CAM技術 1〇 成形裝置而配合病人幾何;或另外選用預製裝置,其具有 最佳配合病人的關節幾何。如前文說明,工具之表面及形 狀可匹配全部或部分關節面或骨面及形狀,例如類似欲植 入裝置之「鏡像」。工具也可包括孔口、開槽及/或孔洞來 容納手術儀器例如鑽及鋸等。工具用於部分關節置換以及 15 全關節置換。例如於全膝關節成形術,工具可用來準確定 位植入物插入所需要的切割平面。藉此方式可達成更可再 現之植入物位置,俾改進臨床結果以及植入物之長期使用 壽命。 典型地選用一種位置,其可獲得解剖上滿意的切割面 20或鑽孔方向供隨後定位植入物。此外,導件裝置可設計成, 可控制鑽或鋸之深度,例如鑽或鋸不可前進至組織内比裝 置厚度界定之深度更深;以及該區塊之孔口大小可設計成 大致上匹配植入物尺寸。有關其它關節或軸之資訊以及關 節或四肢之對正資訊於選擇此等開槽或孔時可含括於該項 70 1231755
施例值供舉例說明之用。第28圖 第28圖顯示適合用於第8L圖所示
配欲使用之植入物刚之外表面組態。裝配手柄⑴2讓使用 者可放置導件於關節内之欲放置植人物刚位置。此外,提 供錫導件UM。此種情況下,每導件iim係於本體⑴〇内 部呈十字形之開口。如熟諳技藝人士已知,錨導件1114可 10具有多種形狀,俾讓導件發揮預定功能。本例中,十字形 讓使用者可識別欲放置錯m(如第几圖所示)於關節之該 關節面。一旦導件·定位於目標關節面,則銷導件ιιΐ4 可用來標記錨接近關節位置;證實錨接近關節位置丨準備 欲定位錨之關節面位置;或其組合。 15 現在參照第29A_B圖所示導件1200,顯示適合用於第 9A-C圖之導件平面圖。提供一本體121〇。該本體係組配成 至少有一外表面係匹配或接近匹配欲植入之植入物外表面 組配狀態。裝配手柄1212讓使用者可放置導件於植入物 欲放置位置。此外,可設置一或多個錨導件1214。本例中, 20 錨導件1214(1214’、1214”、1214,,,)為圓形、或實質圓形開 口於本體1210,該開口直徑夠大而可接納鑽,供對骨内鑽 孔,於該孔内將放置植入物150之錨156之銷。如熟請技藏 人士已知,錨導件1214可有多種適當形狀來讓導件發揮其 預定功能。可設置額外導件1216。額外導件可發揮主導件 71 1231755 1214之相同功能,或可發揮次要功能。本例中,錨導件^“ 可用來識別錨156(顯示於第9B_C圖)定位於關節之關節 面。一旦導件1200置於目標關節面,則銷導件1214可用來 標記錨接近關節位置;證實錨接近關節位置;準備欲定位 5錨之關節面位置;或其組合。另外,導件1216可用來定位 於目標關節面,則錨導件可用來標記錨接近關節位置;證 實錨接近關節位置;準備欲定位錨之關節面位置;或其組 合0 另一具體實施例中可應用支架於患病骨或軟骨以外區 10域之骨或軟骨。支架包括手術器材的夹具及導件。支架可 附著於一點或較佳附著於多個先前界定之解剖參考點。另 外,支木位置可使用造影试驗,例如於手術中獲得一咬多 個螢光鏡影像來相對於一個且較佳多個解剖記號交互對 正。可獲得-或多個電子影像,提供物件座標,^定關節 15面及/或骨面及形狀。此等物件座標可載入或轉入裝置内, 例如以人工或以電子方式載入或轉入,該資訊用來移動一 或多個手術器材之夾具或導件。典型地選用一位置,其可 獲得手術上所需或解剖上滿意的切割面或鑽孔方向性,供 隨後放置-個或另-個植入物,包括半腔、單腔或全部關 2〇節成形術。當選擇開槽或孔位置時可含括有關其它關節或 肘之資料以及關節或四肢之對正資訊。 由於導件係解剖上對正選定之下方關節面,故於適合 工具可形成距導件、鑽孔或挖通裝置導件之較佳定位及^ 向性。於手術中’輔助手術工具應用於關節面上,藉此達 72 1231755 成近完弄^完美之解剖齧合。然後手術醫師經由導件導入 鑛(或其匕工具),準備關節(軟骨或骨)接受手術。經由順著 解剖界定平的開軟纽/騎,可達成更加μ現之定 位,因而最終騎佳化生物機械應力而獲得改良之術後結 果0 此處所述解剖矯正工具可由多種方法製成,可由多種 材料製造,較佳為半透明材料如塑膠、魯塞(Lucite)、西拉
斯丁C SLA等且典型於成形之前為塊狀形狀。此 外,也可形成及採用可再度使用之材料。由非及其它可變 10形材料(例如可調整之緊密間隙銷陣列,其組配成匹配關節 面之地形起伏)。此等具體實施例中,模具可於手術期間直 接由關節製造,或另外,模具可由關節影像製造,例如使 用或夕種電月自程式來決$界定關節表面輪廊之物件座 標,且傳送(例如撥號傳入)座標給工具。隨後工具準確對正 15於關節上,如此鑽孔及植入物可更準確定位於關節面内部 及關節面上。
於可單次使用以及可再度使用之具體實施例,工具係 設計成塊狀物深度控制鑽或鋸深度,亦即鑽或鋸不可比塊 狀物深度更加深入組織,塊狀物之孔尺寸係設計成大致上 20匹配植入物尺寸之各方面。工具用來作一般性贗復物植 入’包括(但非限制性)此處所述關節修補植入物以及於半腔 室、單腔室或全關節成形術或其它關節系統包括生物修補 情況下用來挖空骨髓。 此等手術工具也可用來移除患病軟骨區或略大於患病 73 1231755 軟骨區之面積。 植入部位的辨識及準備、以及植入物的插入可藉影像 導引手術系統(手術導航系統)支援。此種系統中,手術儀器 2對於病人解剖之定位及方向性係於—或多個二維或三維 5影像以即時方式追縱。此等二維或三維影像可由手術前之 影像例如MR或CT影像求出。手術器材之定位及方向性係由 附於手術上的標記器決定。此等標記器可由摘測器使用例 如光信號、聲信號及電磁信號定位。 又有其它具體實施例中,此處所述手術工具包括一或 10多種可硬化而形成關節面模具之材料。多種可於現場硬化 之材料包括可被觸發而進行相變化之聚合物,例如液態或 半液悲聚合物,而當暴露於空氣、施加紫外光、可見光暴 露於血液、水或其它離子變化時可硬化成為固體或凝膠。 (例如參考美國專利第6,443,988號及其中引用之文獻)。適當 15 可硬化材料及硬化材料之非限制性實施例包括聚胺基甲酸 酯材料(例如2002年9月3日核發給Felt等人之美國專利第 6,443,988號;1994年2月22日核發給Khalil等人之 5,288,797 ; 1978年7月 4 日核發給Graham等人之4,098,626 ; 及1986年6月10日核發給Chapin等人之4,594,380 ;以及Lu 20 等人(2000)生物化學21(15):1595-1605說明多孔聚(L-丙交 酯酸泡沫體);親水聚合物例如揭示於1992年11月10曰核發 給Rhee之美國專利第5,162,430號;水凝膠材料例如述於 Wake等人(1995)細胞移植4(3):275-279,Wiese等人(2001) 生醫材料研究期刊54(2): 179-188及Marler等人(2000)塑膠 74 1231755 重建手術105(6):2049-2058 ;玻尿酸材料(例如Duranti等人 (1998)皮膚科手術24(12):1317-1325);可膨脹珠例如幾丁質 珠(例如Yusof等人(2001)生醫材料研究期刊54(1):59-68);及 /或牙科應用材料(例如參考Brauer及Antonucci,「牙科應用」 5 257_258頁於「聚合物科學工程簡明百科」及1983年1月11 曰核發給Weissman之美國專利第4,368,040號)。任一種生物 相容性材料其具有足夠流動性可允許其輸送入關節,以及 於生理可接受之條件下於原位進行完整硬化之材料皆可使 用。該材料也可為生物可分解。 10 15 20 可硬化材料可結合此處所述手術工具使用。例如手術 工具包括一或多個適合接納注入之孔口,可硬化材料通過 孔口注入。於原位固化之前,材料可隨形於面對手術工具 之關節面,如此於硬化時形成表面凹部,因而重新形成正 常或接近正常的關節面。此外,可硬化材料或手術工具也 可結合此處所述任—種影賴驗及影像分析使用,例如基 於關節影像而成形此等材料或手術工具。 况隹麥可弟27A- 、 一 十、我%双不之植入裝置方 法之各個方法步驟。首先使用者作切開來接近目標關節 。隨後使用植人物導件準備關節面勒。關節面的準 紹列如包括辨識植人物躲在關節何處、標記植入物之附 或準備關節面來接納植入物。若有所需可重複此 者=:熟諸技藝人士已知,準備關節面時,使用 物將駐在位置,然後藉標記關節面細 —人備關節面一旦關節面準備妥,安裝植入物 75 1231755 2640。植人物之安裝可藉將植人物置於表面,或使用此處 所述技術將植入物黏著於表面。植入物已經安裝於關節 後,封閉傷口 2650。 現在參考第2 7 B圖所示步驟,使用者作切開來接近目標 5關痛2610。|^後附著支架至關節266〇。雖然未顯示於本流 程圖,可進行第27A圖所示之關節準備步驟。然後植入物安 裝於支架上2665。植入物安裝於關節後,封閉傷口 。 現在參考第27C圖步驟,使用者作切開來接近目標關節 2610。|^後由關節移除患病軟骨267〇。雖然未顯示於本流 φ 程圖,但第Γ7Α圖所示之準備關節之其它步驟也可施行而未 恃離本發明之範圍。然後安裳植入物期。植入物安裝於 關節後,關閉傷口 2650。 現在參照第2 7 D圖所示各步驟,使用者作切開來接近目 «節2610。雖然未顯示於本流程圖,但未恃離本發明之 I5犯圍,也可進行第27A圖所示準備關節之其它步驟。隨後插 入植入物2680。然後選擇性調整植入物位置2682。植入物 已經插入且定位之後,調整植入物之輪廓2684。於植入物 # 已經安裝於關節内部且調整之後,關閉傷口 265〇。選用之 植入物高度及外廓可選定用來變更相對於關節的荷重能 2〇力。此外,可調整植入物高度而考慮骨骼以及關節結構之 解剖上對正錯誤等問題。 VII·套件組 此處也說明包含一或多種此處所述方法、系統及/或組 成物之套件組。特別,一種套件組包括下列一或多者:獲 76 1231755 得電子影像之指米(方法);評估電子影像之系統或指示;一 或多種可分析或處理電子影像之電腦裝置;及/或—或多種 植入植入物之手術工具。套件組包括其它材料例如指令、 試劑、容器及/或造影助劑(例如薄膜、夾具、數位化哭等)。 5 含括下列實施例供更完整舉例說明本發明。此外此等 實施例提供本發明之較佳具體實施例而非意圖限制本發明 之範圍。 則文本發明具體霄施例之詳細說明僅供舉例說明之 用。絕非羅列盡淨或限制本發明於所揭示之精準形式。熟 φ Π)諳技藝人士顯然易知其它修改及變化。該等實施例經選用 及說明來最明白解說本發明之原理及其主要應用,因而讓 業界人士可了解本發明及適合預期特定用途之各具體實施 例及各修改例。本發明之範圍僅由如下申請專利範圍及其 相當範圍界定。 15 【圖式簡單說明】 第ΙΑ、1B圖為根據本發明,評估需要修補之關節之方 法之方塊圖。 鲁 第2圖為遠端股骨關節軟骨之三維厚度圖之再現。第3a 圖顯示同心設置光圈之帕西多圓盤範例。第犯圖顯示投影 20於具有固定曲率表面之帕西多圓盤範例。 巧第4圖顯示同心光圈(帕西多圓盤)投影於各個股骨鍊所 得之反射’驗證表面輪靡變化對反射圓之影響。 第5圖顯示不規則彎'曲面之二維加色碼之地形圖範例。 第6圖顯示不規則彎曲面之三維加色碼之地形圖範例。 77 1231755 第7A-B圖為根據本發明,評估需要置換關節之方法之 方塊圖。 第8A圖為適合植入膝關節之脛骨岡之本發明關節植入 物之透視圖。第8B圓為第8A圖植入物之頂視圖。第8C圖為 5 第8B圖之植入物沿第8B圖之視線C-C所取之剖面圖。第8D 圖為第8B圖沿視線D-D所取之剖面圖。第8E圖為第8B圖沿 視線E-E所取之剖面圖。第8F圖為第8A圖之植入物之側視 圖。第8G圖為第8A圖之植入物顯示植入後沿平行於矢狀平 面之平面所取之剖面圖。第8H圖為第8 A圖之植入物顯示植 10 入後沿平行於冠狀平面之平面所取之剖面圖。第81圖為第 8A圖之植入物顯示植入後沿平行於軸向平面之平面所取之 剖面圖。第8J圖顯示於正中(朝向脛骨岡邊緣)及向前及向後 延伸接近骨之略大的植入物。第8K圖為第8A圖之關節植入 物之另一具體實施例之側視圖,顯示一錨。第8L圖為第8A 15 圖之關節植入物之另一具體實施例之底視圖,顯示一錨。 第9A及9B圖為適合用於股骨髁之關節植入物由下表 面及上表面觀視分別所得之透視圖。第9C圖為第9A圖植入 物之側視圖。第9D圖為植入物之下表面視圖;第9E圖為植 入物之上表面視圖,以及第9F圖為植入物之剖面圖。第9G 20 圖為適合用於二股骨髁之關節植入物上表面之視圖。第9H 圖為第9G圖之植入物之透視側視圖。 第10A圖為髖臼之側視圖。第10B圖為近端股骨之旋轉 視圖。第10C圖為髖關節植入物之剖面圖。 第10D圖為類似第10C圖之植入物之剖面圖。 78 1231755 第11A圖為具有元件延伸入股骨頭小窩之植入物之剖 面圖。第11B圖顯示植入物為半球形,第11C圖顯示為部分 半球形及第11D圖顯示為軌形。第11E圖為具有輪輻配置之 植入物之具體實施例。 5 第12A圖為植入物之剖面圖。第12B-E圖顯示植入物的 數個透視圖。 第13A圖為雙元件式「活動軸承」植入物之剖面圖。第 13B-F圖為平面圖,顯示具有二半球之二元件。 第13G-J圖為雙元件式植入物之另一具體實施例。 10 第14A圖為植入物之另一具體實施例。第14B圖及第 14C圖顯示剖面圖具體實施例。 第15A圖為雙元件式「活動軸承」植入物之剖面圖。第 15B及15C圖顯示植入物之剖面圖。 第16A圖為雙元件式「活動軸承」植入物之剖面圖。第 15 16B-D圖為三元件式「活動軸承」植入物之剖面圖。 第17A圖為雙元件式「活動軸承」植入物之剖面圖。第 17B及17C圖顯示植入物之剖面圖。 第18A、18B圖分別為雙元件式「活動軸承」植入物之 剖面圖、頂視圖。 20 第19A圖為雙元件式「活動軸承」植入物之剖面圖。第 19B圖為雙元件式固定植入物之剖面圖。 第20A圖為具有不等半徑及厚度之供髖關節用之植入 物之剖面圖。第20B圖為具有不等半徑及厚度之供髖關節用 之植入物之剖面圖。第20C圖為具有不等半徑及厚度之供髖 79 關即用之植入物之剖面圖。第20D圖為體關節用之植入物之 剖面圖。 第21AB1為肩關節之骨質結構之前視圖。第21B圖為置 放,骨頭與關節窩間之關節成形裝置之視圖。第21C圖為 關即成形裝置之斜向前視剖面圖。第21D®為關節成形裝置 之麵剖面圖。第21E圖肩關節之斜向前視圖。第训圖為 、1節之軸向視圖。第21G圖為關節成形裝置之斜向前視剖 Ί第21H圖為關節成形裝置之軸向剖面圖。第211圖為 關節成形裝置之斜向前視剖面圖。第21J圖為關節成形裝置 之轴向剖面圖。第21K圖為雙元件式「活動軸承」關節成形 裝置之斜向前視剖面圖。 第21L圖為雙兀件式「活動轴承」關節成形裝置之轴向 剖面圖。第讀圖為雙元件式「活動軸承」關節成形裝置 之另一視圖。 第21Ν圖為雙几件式「活動轴承」關節成形裝置之斜向 前視剖面圖。第210圖為雙元件式「活動軸承」關節成形襄 置之斜向前視剖面圖。第21PAQ圖為第21〇圖所示雙重活 動軸承裝置之另一具體實施例之剖面圖。 第22圖為通過肘關節之斜向縱視圖。 第23A圖為通過腕關節之縱視圖。第23B圖為通過腕關 節之縱視圖。第23C圖為通過腕關節之縱視圖。第23D圖為 適合用於腕骨之雙元件式「活動軸承」關節成㈣置之縱 剖面圖。第23E圖為另—雙元件式關節成形裝置之縱剖面 圖’本例不含脣。第23F圖為雙元件式「活動轴承」關節成 1231755 形裝置之縱剖面圖。 第24圖為通過手指之矢狀視圖。 第25A圖為通過踝關節之矢狀視圖。第25B圖為通過踝 關節之冠狀視圖。第25C圖為通過踝關節之矢狀視圖。第 5 25D圖為通過踩關節之冠狀視圖。 第26圖為通過腳趾之矢狀視圖。 第27A-D圖為將本發明裝置植入目標關節採用之各方 法步驟之方塊圖。 第28圖為植入第8L圖所示裝置時適合使用之植入導件 10 工具之平面圖。 第29A及29B圖為植入第9B圖所示裝置時適合使用之 植入導件工具之平面圖。 81 1231755 【圖式主要元件代表符號表j 10.. .獲得目標關節測量值 1卜31,41,5卜53...選擇性重複步驟 24,25,26,42,43,44…流程 30…產生目標關節之模式呈現 32,38,39…箭頭 40.. .產生目標關節之投影模式呈現 50.. .選擇適當之關節置換植入物 52.. .設計適當之關節置換植入物 60.. .獲得目標關節測量值 6卜71,81,91,93…選擇性重複步驟 65,66,67,76,77,78…流程 70.. .測量關節缺損 80…識別適合用於修補缺損之裝置 90.. .選擇用來修補缺損之裝置 92.. .製造用來修補缺損之裝置 100…關節植入物 102.. .上表面 104.. .下表面 106.. .周緣 108…外形,上緣 110.. .下緣 112.. .關節錨 114.. .橫桿 120.. .膝關節 122.. .脛骨岡 124…股骨,上關節面 150,151...植入物 152.. .彎曲匹配面 154.. .凸面關節毗鄰面 156.. .銘 200.. .髖臼 202.. .軟骨覆蓋區 204…髖臼小窩 206…股骨頭小窩 210.. .近端股骨 220.. .髖關節 82 1231755 221,240,250...植入物 222…内面 224.. .髖臼 226.. .圓化緣 230…結節 230,231...元件 232…凸部 240.. .股骨頭 242,244.··元件 243,245,252,254.··元件 246,253·..結節 248,255...凸部 262…銷 264,264\264'264’”…翅片 266…錫 268,268’...栓 470.. .植入物 300.. .肩關節 302.. .鎖骨 304.. .肩胛 306.. .肩胛骨關節窩 306’,306”··.内窩脣 307’,307”...後窩胥 308.. .肩峰 310.. .喙突 312.. .肱骨 313.. .肱骨頭 314,316...軟骨覆蓋區 320.. .關節成形裝置 322,342...肱骨接觸面 324,344…關節窩接觸面 346,346’,346”,346,”…凸部或脣 520.. .關節成形裝置 350.. .關節成形裝置 351,353...元件 352,354.骨接觸面 356,358…關節植入物表面 3 60...植入物 1231755 362,364...元件 363…關節窝接觸面 365.. . 370.. .關節成形裝置 372.. .肱骨接觸元件 373.. .銷釘 374.. .關節軟骨 600.. .肘關節 602.. .遠端肱骨 603,605,607…軟骨面 604.. .鷹嘴突 606.. .橈骨頭 608.. .尺骨 610.. .橈骨 620.. .關節成形裝置 700.. .腕關節 702.. .選端橈骨 704.. .尺骨 706.. .腕骨列 706,,706”,706,”·.·關節面 708.. .三角形纖維軟骨 710.. .尺骨莖 720.. .關節成形裝置 730.. .關節成形裝置 732…脣 740.. .關節成形裝置 742-745...元件 746,748…脣 750.. .關節成形裝置 752-755...元件 760.. .關節成形裝置 762.. .元件 766…錨 800…指 802.. .掌骨頭 804.. .近端指骨 820.. .關節成形裝置 822.··— 側 1231755 824.. .對側 900.. .踝關節 902.. .遠端脛骨 904…距骨 9045.. .距骨圓頂 906…跟骨 908.. .遠端腓骨 920,930,940…關節成形裝置 942.. .關節成形系統 944.. .上表面 946…脣 950.. .關節成形裝置 952.. .下表面 954.. .上表面 1000…趾 1002.. .跛骨頭 1004.. .近端趾骨 1020.. .關節成形裝置 1022,1024··.表面 1100.. .植入導件 1110…關節隨形體 1112·.·柄 1114.. .錨導件 1200.. .導件 1210.. .本體 1212…柄 1214,1214,,1214”,1214”’,1216…錨導件 2610…作切開而接近目標關節 26U,2621,2641,266卜267卜268卜2682…選擇性重複步驟 2620.. .使用植入物導件製作關節面 2640…安裝植入物於關節表面上 2650…閉合傷口 2651-3,2663-5,2673-5,2685-7···流程 2654,2662,2672...箭頭 2660.. .施加支架至關節 2670.. .移除患病軟骨 2680…定位植入物 2684…調整植入物外廓 85
Claims (1)
1231755 9 3 1111 第〇92127826號發明專利申請”請專利範圍修正本 修正日期:93年11月 拾、申請專利範圍: i 一種插置式關節植人物,其具有—上表面及—下表面, 其中該上表面係與-關節之―第—關節面相對,以及該 下表面係與該關節之—第二關節面相對,此外其中上表 面或下表面中之至少-者具有—種三維形狀,該三維形 狀具有實質上匹配第一關節面及第二關節面中之一者 之形狀。 • t申請專利範圍第!項之植入物,其中該植入物係置於 選自下列組成之群組之-關節内部:膝、髖、肩、肘、 腕、指、趾及踝。 如申請專利範圍第!項之植人物,其中該上表面及該下 15
表面具有-種三維形狀’其實質上匹配該上表面田比鄰之 關節面及該下表面眺鄰之關節面中之至少一者之形狀。
如申請專利範圍第1項之植人物,其中該植人物具有病 人之軟骨缺損之厚度。 5·如申請專利範圍第!項之植人物,其中該植人物具有病 人之軟骨缺損之85%之厚度。 6.t申請專利範圍第1項之植人物,其中該植人物具有病 人之軟骨缺損之65。/。-1〇0%之厚度。 請專利項之植人物,其中該植人物係由— 種包含金屬或金屬合金之材料组成。 8’如申請專利範圍第1項之植入物,其中該材料進-步包 20 Ϊ231755 含一或多種生物活性材料。 ’其中該植入物被塗覆 其中該檀入物包含金 進一步具有一種選自 9·如申請專利範圍第7項之植入物 以一種生物活性材料。 5 10 15 10·如申請專利範圍第】項之植入物 屬或金屬合金之聚合物。 如申請專利範圍苐】項之植入物,遲—步具有1 二列組成之群組之附著於關節用之機構:[松 '銷 松捍、齒及凸部。 如申請專利範圍第】項之植入物,進—步X 】3.如申請專利範圍第】項之植入物,進―牛二:。 1A . ^ 疋艾具有| 〇 •。:'專利範圍第】項之植入物’其中該植入物進一步 匕含一第一元件以及一第二元件。 】5·如申請專利顚第14項之植人物,其中該第—元件及第 ^件屬於下列任-者··整合成形、不可分割成形、互 連成形以及各自獨立成形。 16·如申請專利範圍第Μ項之植人物,其中該第_元件 固定式、滑動式、及旋轉式中之至少_種 1 7上士 w 士 /ΖΓ 4安口關即。 .D申h專利範圍第14項之植入物,其中該第二元件係以 固定式、滑動式、及旋轉式中之至少―種方法 : 申請專利範圍第]4、15、16或17項之植入物,其= 第一元件接合該第二元件。 ^ 19.=申請專利範圍第14、15、16或17項之植入物,其中該 第一元件齧合於該第二元件内部。 % 20·如申請專利範圍第]心]5、]6或]7項之植入物,1 /、中該 20 1231755 第一元件滑動式接合該第二元件。 21. 如申請專利範圍第14、15、16或17項之植入物,其中該 第一元件旋轉式接合該第二元件。 22. 如申請專利範圍第1項之植入物,其中該植入物具有複 5 數個元件。 23. 如申請專利範圍第22項之植入物,其中複數個元件中之 一第一元件係以固定式、滑動式及旋轉式中之至少一者 接合關節。 24. 如申請專利範圍第22項之植入物,其中複數個元件中之 10 —第二元件係以固定式、滑動式及旋轉式中之至少一者 接合關節。 25. 如申請專利範圍第22、23或24項之植入物,其中複數個 元件中之第一元件接合該複數個元件中之第二元件。 26. 如申請專利範圍第22、23或24項之植入物,其中複數個 15 元件中之第一元件齧合於複數個元件中之第二元件内 部° 27. 如申請專利範圍第22、23或24項之植入物,其中複數個 元件中之第一元件滑動式接合該複數個元件中之第二 元件。 20 28.如申請專利範圍第22、23或24項之植入物,其中複數個 元件中之第一元件旋轉式接合該複數個元件中之第二 元件。 29.如申請專利範圍第1項之植入物,其中該植入物具有一 種沿周邊形成之形狀係選自下列形狀組成的群組:圓 1231755 形、橢圓形、㈣、腎臟形、實質圓形、實質橢圓形、 實質卵形及實質腎臟形。 3〇·如申請專利範圍第!項之植入物,其中該植入物具有一 下表面及上表面中之至少一者之截面形狀係選自由球 5 形、半球形、非球形 '凸面、凹面、實質凸面及實質凹 面組成的群組。 3!.如申請專利範圍第!項之植入物,其中該植入物為—種 軟骨缺損隨形植入物。 32. 如申請專利範圍第!項之植入物,其中該植入物為一種 10 軟骨凸起植入物。 33. 如申請專利範圍第!項之植入物,其中該植入物為—種 軟骨下骨隨形植入物。 34·如申請專利範圍第!項之植入物,其中該植入物係經由 10厘米或以下之切開而以手術方式楂入。 15 35·如申請專利範圍第1項之植入物,其中該植入物係經由6 厘米或以下之切開而以手術方式植入。 36·如申請專利範圍第!項之植入物,其中該植入物係經由3 厘米或以下之切開而以手術方式植入。 37.如申請專利範圍第i項之植人物,其中該關節之活動範 20 圍係回復至正常關節活動範圍之80-99.9%間。 38·如申請專利範圍第丨項之植入物,其中該關節之活動範 圍係回復至正常關節活動範圍之90-99.9%間。 39.如申請專利範圍第丨項之植入物,其中該關節之活動範 圍ϋ回復至正常關節活動範圍之9%間。 1231755 4〇·如申請專利範圍第1項之植入物,其中該關節之活動範 圍係回復至正常關節活動範圍之98-99.9%間。 41=申請專利範圍第1項之植人物,其中該關節為膝關 即’以及其中-種沿—周邊形成之形狀係選自下列形狀 5 :的群組:圓形、橢圓形,形、腎臟形、實質圓形、 貫質搞圓形、實質印形及實質腎臟形。 =中請專利範圍第丄項之植人物,其中該關節為膝關 ^以及其中該植入物之上表面為實質凸面形。
1Q 43.如申請專利範圍第1項之植入物,其中該關節為膝關 即,以及其中該植入物之下表面為實質凹面形。 44t申請專利範圍第1項之植入物,其中該關節為膝關 即’以及其中雜人物之上表面為由凸面形及凹面形組 成0 45t申請專利範圍第1項之植入物,其中該關節為膝關 P以及其中該植入物之下表面為實質凹面形。 46·t申請專利範圍第1項之植入物,其中該關節為髖關
即,以及其中該植人物之剖面係選自由球面及非球面組 成的群組。 47.t申請專利範圍第1項之植人物,其中該植人物周邊之 厚度係比該植入物中部之厚度更大。 後如申請專利範圍fl項之植人物,其中該植人物之中部 具有厚度比周邊更大。 後如申請專利範圍第丨項之植人物,其具有—前部、一後 部、-外側部以及-正”,其中該植入物具有沿該裝 1231755 置後部之厚度係等於或大於該植入物外側部、正中部及 前部中之至少一者之厚度。 50. 如申請專利範圍第1項之植入物,其具有一前部、一後 部、一外側部以及一正中部,其中該植入物具有沿該裝 5 置後部之厚度係等於或小於該植入物外側部、正中部及 前部中之至少一者之厚度。 51. 如申請專利範圍第1項之植入物,其具有一前部、一後 部、一外側部以及一正中部,其中該植入物具有沿該裝 置正中部之厚度係等於或小於該植入物前部、後部及外 10 側部中之至少一者之厚度。 52. 如申請專利範圍第1項之植入物,其具有一前部、一後 部、一外側部以及一正中部,其中該植入物具有沿該裝 置正中部之厚度係等於或大於該植入物前部、後部及外 側部中之至少一者之厚度。 15 53.如申請專利範圍第14或22項之植入物,其具有一前部、 一後部、一外側部以及一正中部,其中該植入物之至少 一元件具有沿該裝置後部之厚度係等於或大於該植入 物外側部、正中部及前部中之至少一者之厚度。 54, 如申請專利範圍第14或22項之植入物,其具有一前部、 20 一後部、一外側部以及一正中部,其中該植入物之至少 一元件具有沿該裝置後部之厚度係等於或小於該植入 物外側部、正中部及前部中之至少一者之厚度。 55. 如申請專利範圍第14或22項之植入物,其具有一前部、 一後部、一外側部以及一正中部,其中該植入物之至少 1231755 ::::有沿該裝置正中部之厚度係等於或小於該植 入物刖邰、後部及外側部中之至少一者之严声 56.如申請專利範圍第14或22項之 ::。 丹具有一丽部、 -後。卜-外侧部以及一正中部,其中該植入物之至少 一:件具有沿該裝置正中部之厚度係等於或大於該植 入物W部、後部及外側部中之至少_者之厚戶 57.-種製造適合_關節之植人物之方法,該方子= 步驟: U 3广幻 10 決定該關節之-或多個關節面之三维形狀; 製造-具有—上表面及一下表面的植入物,其中該 上表面及下表面相對於該關節之第_關節 —步其中該上表面或下表面中之至二二 貫質匹配該關節面之三維形狀。 58·:=;=57項之方法,其中該三維形狀— Κ于關即之景>像決定。 说如申請專利範圍第58項之方法,其中該 mRI、ct、x光及其組合組成的群組。 a自由 15
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US20040138754A1 (en) | 2004-07-15 |
US20040133276A1 (en) | 2004-07-08 |
CA2501041A1 (en) | 2004-04-22 |
WO2004032806A1 (en) | 2004-04-22 |
US7799077B2 (en) | 2010-09-21 |
US20110066245A1 (en) | 2011-03-17 |
WO2004032806A9 (en) | 2004-05-27 |
EP1555962A1 (en) | 2005-07-27 |
DE60336002D1 (de) | 2011-03-24 |
US8709089B2 (en) | 2014-04-29 |
AU2003284035A1 (en) | 2004-05-04 |
HK1072710A1 (en) | 2005-09-09 |
EP1555962B1 (en) | 2011-02-09 |
US20140250676A1 (en) | 2014-09-11 |
US9872773B2 (en) | 2018-01-23 |
JP2006501977A (ja) | 2006-01-19 |
ATE497740T1 (de) | 2011-02-15 |
TW200412918A (en) | 2004-08-01 |
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