TW565569B

TW565569B - Novel polypeptides for inducing the production of interferon-gamma

Novel polypeptides for inducing the production of interferon-gamma Download PDF

Info

Publication number: TW565569B
Authority: TW; Taiwan
Prior art keywords: ser; asp; lys; lie; glu
Prior art date: 1996-11-29

Application number

TW086117857A

Other languages

English (en)

Chinese (zh)

Inventor

Kozo Yamamoto

Iwao Okamoto

Masashi Kurimoto

Original Assignee

Hayashibara Biochem Lab

Priority date

1996-11-29

Filing date

1997-11-27

Publication date

2003-12-11

1997-11-27 Application filed by Hayashibara Biochem Lab filed Critical Hayashibara Biochem Lab

2003-12-11 Application granted granted Critical

2003-12-11 Publication of TW565569B publication Critical patent/TW565569B/zh

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108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 276
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 229
229920001184 polypeptide Polymers 0.000 title claims abstract description 212
238000004519 manufacturing process Methods 0.000 title claims abstract description 36
230000001939 inductive effect Effects 0.000 title claims abstract description 16
108010074328 Interferon-gamma Proteins 0.000 title abstract 4
229960003130 interferon gamma Drugs 0.000 title abstract 3
102000008070 Interferon-gamma Human genes 0.000 title 1
150000001413 amino acids Chemical group 0.000 claims abstract description 122
235000001014 amino acid Nutrition 0.000 claims abstract description 69
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 43
201000010099 disease Diseases 0.000 claims abstract description 42
235000018417 cysteine Nutrition 0.000 claims abstract description 22
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 21
201000011510 cancer Diseases 0.000 claims abstract description 16
230000003013 cytotoxicity Effects 0.000 claims abstract description 15
231100000135 cytotoxicity Toxicity 0.000 claims abstract description 15
208000015181 infectious disease Diseases 0.000 claims abstract description 11
230000003612 virological effect Effects 0.000 claims abstract description 9
108020004414 DNA Proteins 0.000 claims description 90
238000011049 filling Methods 0.000 claims description 89
239000002773 nucleotide Substances 0.000 claims description 84
125000003729 nucleotide group Chemical group 0.000 claims description 84
229940024606 amino acid Drugs 0.000 claims description 60
230000002079 cooperative effect Effects 0.000 claims description 52
108010009298 lysylglutamic acid Proteins 0.000 claims description 41
NRQRKMYZONPCTM-CIUDSAMLSA-N Lys-Asp-Ser Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NRQRKMYZONPCTM-CIUDSAMLSA-N 0.000 claims description 38
108010012581 phenylalanylglutamate Proteins 0.000 claims description 38
KPYAOIVPJKPIOU-KKUMJFAQSA-N Leu-Lys-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O KPYAOIVPJKPIOU-KKUMJFAQSA-N 0.000 claims description 37
GKZIWHRNKRBEOH-HOTGVXAUSA-N Phe-Phe Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)C1=CC=CC=C1 GKZIWHRNKRBEOH-HOTGVXAUSA-N 0.000 claims description 37
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JWQWPTLEOFNCGX-AVGNSLFASA-N Phe-Glu-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 JWQWPTLEOFNCGX-AVGNSLFASA-N 0.000 claims description 36
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SKRGVGLIRUGANF-AVGNSLFASA-N Lys-Leu-Glu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O SKRGVGLIRUGANF-AVGNSLFASA-N 0.000 claims description 28
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KWUKZRFFKPLUPE-HJGDQZAQSA-N Lys-Asp-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O KWUKZRFFKPLUPE-HJGDQZAQSA-N 0.000 claims description 26
KYXDADPHSNFWQX-VEVYYDQMSA-N Met-Thr-Asp Chemical compound CSCC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C(O)=O)CC(O)=O KYXDADPHSNFWQX-VEVYYDQMSA-N 0.000 claims description 26
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