TW513422B - Bicycloamino derivative and PGD2 antagonist containing the derivative - Google Patents

Bicycloamino derivative and PGD2 antagonist containing the derivative Download PDF

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TW513422B
TW513422B TW085107425A TW85107425A TW513422B TW 513422 B TW513422 B TW 513422B TW 085107425 A TW085107425 A TW 085107425A TW 85107425 A TW85107425 A TW 85107425A TW 513422 B TW513422 B TW 513422B
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Mitsuaki Ohtani
Akinori Arimura
Tatsuo Tsuri
Junji Kishino
Tsunetoshi Honma
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Shionogi & Amp Co Ltd
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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13422 經濟部中央標準局員工消費合作社印製 A7 R7 五、發明説明（1 ) 本發明係有關一種雙環環条胺基衍生物及含有該衍生 物之前列腺素Ds (M下稱PGDS)拮抗劑。 關於本發明之雙環環条胺基衍生物之一部分者已知可 用來作為凝血檄素Aa (TXA2)拮抗劑（特公平5-79060號說 明書）。但，關於記載於特公平5-79060號之化合物並均 不過僅揭示用來作為TXAS拮抗劑之有用性而已，對於本發 明揭寒之P G D 2拮抗劑的用途絲毫未暗示。 亦即，TXAat作用已知有血小板凝集作用、血栓形成 作用等，但，TXA2拮抗劑被認爲可對ΤΧΑ2·行拮抗，可用 來作為抗血栓劑、心肌梗塞、哮喘之治療劑。 另外，本發明之PGDB拮抗劑可用於改善起因於PGD2t 生產過多之症狀，更詳而言之，可用來作為肥胖細胞功能 不全相關之疾病，例如，全身性肥胖細胞症及全身性肥胖 細胞活性化障礙的治療劑、進而係抗氣管收縮劑、抗哮喘 劑、抗過敏性鼻炎劑、抗過敏性結膜炎劑、抗尊麻疹劑、 缺血再灌流傷害治療藥、抗炎症劑。 從上述明顯可知，1%纟2拮抗劑與卩6卩8拮抗劑之作用點 、機序均不同，同時適應亦相異，係完全不同性質者，故 某化合物同時具有此等作用者乃完全無法預測。 PGDa係從肥胖細胞產生游離之最主要的類前列腺素， 以及藉著一受免疫學或非免疫學上剌激而活性化之加環氧 酸（cyclooxygenase)，而從花生四烯酸經PGG2、PGHa所產 生者。PGD2具有各種強力生理的、疾病的作用，例如，引 起很強氣管收縮，進而造成支氣管哮喘的疾病，Μ及於全 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 5 $·------、訂-------^^^1 (請先閲讀背面之注意事項再填.舄本頁) 513422 舊土 Λ7 本？, ”月曰1 Τ： 、 ZlL PF --- irr-2~^--] 身性過敏狀態中，使末梢血管擴張，而形成過敏性衝擊之 原因。特別是，M PGDa作為過敏性鼻炎之鼻塞症狀顯現的 原因物質之一的想法，乃倍受注意。因此，以減輕鼻塞症 狀作為目的之藥物曾被想到PGDa2生合成阻礙劑、或受容 體拮抗劑的開發。但，PGD2t生合成阻礙劑因有可能對在 其他活體內之前列腺素類的合成造成很大的影響，故希望 能開發出對於PGD2受容膿非常卓越的PGDa受容體拮抗劑（ 遮蔽藥）。 本發明人等為開發對PGD2受容髏非常卓越的PGDa受容 體拮抗劑（遮蔽藥），經銳意硏究之結果，發現Μ下述通 式（I )所示之化合物或其鹽作為PGD2受容體拮抗劑具有很 強的作用，且，為化學性、生化性上安定的化合物，終完 成本發明。 亦即，本發明係提供一種PGD2拮抗劑組成物，其係含 有一K式（I ) (請先閱讀背面之注意事項再填寫本頁)
經濟部中央標準局員工消費合作社印製 所示之雙環之環条胺基衍生物或其鹽亦或水合物作為 有效成分者；（上述式中， α 表示 6 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ29?公釐）
經濟部中央標準局員工消費合作社印製 CX ¢( ¢( $ Cx， A亦可介於雜原子或亞苯基，亦可具有氧基，及/或 亦可具有不飽和鍵之院撐基； B為氫、烷基、芳烷基或醸基； R為 COORi、CH2ORs或C0N(Rs)R4;
Ri爲氫或烷基； fU為氫或烷基； R3及IU分別為氫、烷基、羥基或烷基磺酿基；
Xi為單鍵、亞苯基、亞禁基、噻盼二基、B5I跺二基或 噁睡二基； χ2^單鍵、-N = N-、-N = CH-、-CH = N-、-CH = N-N-、 -CH = N-0-、-ONNHCSNH、-C = NNHC0NH-、-CH = CH_、-CH(OH)-、-C(C1)=C(C1)-、-(CHa)n-、乙炔基、 -N(RB)-、 -N(Rei)C0-、-N(Re2)S02-、 -N(Re3)C0N(Re4)-、-C0N(Ree)-、_S〇2N(Re6)--S-、-SO-、-SOr 、-C0-、噁嗪唑二基、_嗪唑二基或四唑二基； X3為烷基、烯基、炔基、芳基、芳烷基、雜環、環烷 基、環烯基、噻唑啉亞基甲基、噻唑烷亞基甲基、-CH = NRs 或-N = C(R77Re ;
Re、Rei、Rea、Rb3、Re·*、Rea 及 Res 為氮或院基； IU為氫、烷基、羥基、烷氧基、氨甲酿基氧基、硫氨 甲醯基氧基、脲基、硫脲基； 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） ---------^0,-----’訂 ------^0— (請先閱讀背面之注意事項再填寫本頁) >13422 Λ7 B7 五、發明説明（ 只7及1^分別為烷基、烷氧基或芳基； η為1或2 ; Ζ為-S03-或-C0-; 姐為0或1 ; 於此等定義中，取代基為環狀者亦可被選自硝基、焼 氧基、氨磺醯基、取代或非取代胺基、醯基、醯氧基、經 基、鹵素、烷基、炔基、羧基、烷氧基羰基、芳烷氧基锻 基、芳氧基羰基、甲磺醯氧、氟基、烯氧基、羥烷基、三 氟甲基、烷硫基、-N = PPh3、氧基、硫基、羥亞胺基、烷 氧基亞胺基、苯基及烷撐二氧基中之1〜3艏基所取代） 0 用以奮施發明：> 慕住形能 若進一步具體表示能成為上述PGDS拮抗劑的化合物， 可舉出於式（I)所示之化合物中， 乃表示 經濟部中央榡準局員工消費合作社印製 α m爲0、Ζ為S〇2時，Xi及Χ2均爲單鍵，Χ3為烷基、苯基 、萘基、苯乙烯基、喹啉基或噻盼甲基，於此等取代基之 中，環狀者亦可被選自硝基、烷氧基、取代或非取代胺基 、鹵素、烷基及羥基烷基中之1〜3個基所取代的化合物 或其鹽亦或水和物。 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇X29*7公釐） 8
_ Q --------------IT--------0Φ— (請先閱讀背面之注意事項再填寫本頁) 513422 A7 B7 五、發明説明（5 ) 同樣地，於Μ式（I )所示的雙環之環条胺基衍生物中 ，舉例 ! 乃表示
(請先閲讀背面之注意事項 經濟部中央標準局員工消費合作社印製 DI為1時，Xi及Xa均爲單鍵，Χ3爲亦可被鹵素所取代之 苯基的雙環之環条胺基衍生物或其鹽亦或水和物。 同樣地，於以式（I )所示的雙環之環条胺基衍生物中 ，舉例 Q 乃表示 α % m為1時，X為苯基，Xa為-CHa-或-Ν = Ν-，Χ3為苯基的 雙環之環条胺基衍生物或其鹽或水和物。 同樣地，一種Μ式（I )所示的雙環之環条胺基衍生物 或其鹽或水和物，係Μ式（la)所示，
NIB X1-02 (式中，A、B、R、Xi、乂2及\3乃與前述之定義相同 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐）
本頁)
、1T 9 513422 B7
A—R
五、發明説明（ 但，⑴Xi及χ2為單鍵、χ3為取代或非取代苯基或萘基 、及⑵Α為5-庚亞烯基、R為cOORid爲氫或甲基）、 1,4-亞苯基、X2^單鍵、χ3為苯基時除外）。 同樣地，一種Μ式（I )所示的雙環之環条胺基衍生物 或其鹽或水和物，係Μ式（I b), (lb) co—x 广 x2 · (式中，
Q 係表示 (請先閱讀背面之注意事項再填寫本頁)
‘-VT
或 €ί 經濟部中央榡準局員Η消費合作衽印製 A、B、R、Xi、乂2及乂3乃與前述之定義相同Μ旦，Xi 及X«為單鍵，X3為苯基時及Xi為單鍵、Xa^-0-時，X3為 苯甲基時除外）所示。 進而更具體地，於Μ式（la)所示之化合物中，可舉 例如Xi及X2^單鍵，X3為異噁唑基、__唑基、異噻唑基 、嗎啉基、H5I哚基、苯并呋喃基、二苯并呋喃基、二苯 并二氧基、苯并_盼甲基、二苯并_盼甲基、唑基、氧 雜蒽基、酚三嗪基、二苯并噁吡基、二苯并_吡基、 二氮雜萘基、氧萘基、苯并眯唑基或二氫苯并_吡基之 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 10 513422 Α7 Β7 i、發明説明（7 ) 化合物或其鹽或水和物。 同樣地，於Μ式（la)所示之化合物中，可舉例如X* 為單鍵、X»為亞苯基、\3為烷炔基、烷烯基、-CH = NRe或 - N = C(R7)Re之化合物或其鹽或水和物。 同樣地，於Μ式（I a)所示之化合物中，可舉例如R表 示COOR，Xi表示亞苯基或噻盼二基，Xa表示單鍵、-N = N -、-CH = CH_、-CONH-、-NHCO-或亞乙烯基，X3表示苯基、 睡唑烷基甲基、噻唑嗪烷基甲基或睡吩甲基之化合物其鹽 或水和物。 更具體而言，於Μ式（I b>所示之化合物中，可舉例 如 乃表示 α 之化合物或其顗或水和物。進而更佳之態樣係於Μ式（lb )所示之化合物中，可舉例如R乃表COORi (h之定義同於 前述）之化合物或其鹽或水和物。 同樣地，於以式（I b)所示之化合物中，可舉例如 Xi為亞苯基或唾盼二基，Xa^單鍵、-N = N-、-CH = CH- , 1, 2-亞乙烯基、-0_、_S_、-C0_、-C0N(Rae)- (Rae 之定義 同於前述）、-N(Rei)C0- (Rai之定義同於前述）及X3為 苯基之化合物或其鹽或水和物。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再IP本頁) 、τ 經濟部中央標準局員工消費合作社印製 11 513422 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（8 ) 更具體而g，於以式（I b〉所示之化合物中，可舉例 如Q' 乃表示 之化合物或其鹽或水和物。進而較佳之態樣可舉例如B為 氫，Xi及Xa均為單鍵，X3為睡吩甲基、睡唑基、唾嗪唑基 、異睡唑基、Ift咯基、吡啶基、苯并呋喃基、苯并眯唑基 、苯并睡吩甲基、二苯并呋喃基、二苯并睡吩甲基、喹啉 基或蚓跺基之化合物或其鹽。同樣地，可舉例如Xt為亞苯 基、噻盼二基、8¾哚二基或畷唑二基、乂2為單鍵、-N = N-、-CH = CH-、1,2-亞乙烯基、-S-、或-0-、及X3為芳基或 雜環之化合物或其鹽或水和物。 又，上述通式（la)及（Ib>所示之化合物係本發明人 等所合成出的新穎化合物。 本說明書中所使用之各種語句的定義如以下般。「烷 撐基」乃指G〜C3之直鍵或分枝狀的烷撐基，例如亞甲基 、甲基亞甲基、二甲基亞甲基、甲乙基亞甲基、乙烯、三 亞甲烯、四亞甲基、五亞甲基、六亞甲基、七亞甲基、八 亞甲基或九亞甲基等。上述烷撐基亦可介在雜原子（氧原 子、硫原子或氮原子等）或亞苯基（例如1,4-亞苯基、 1,3-亞苯基、1,2-亞苯基等），亦可具有氧代基、及/或 (請先閱讀背面之注意事項再本頁)
訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 12 513422 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（9 ) 於鍵上任意位置亦可含有雙鍵或三鍵1値或1値以上。例 如：一（CHa>a-〇-CHa-、 _(CHa)a-〇-(CH2)a-、-(CHa)a-0-(CHa)3-、-(CH山-0_(CH 山-、-（CH山-〇-(CHa)e-、 -(CHa)a-0-(CHa)s-、-（CHa)a-S-（CHa)a-、-(CHa)3-S-(CHa〉a-、-CHa-S - CHa-、-CHa-S-(CHa)r、- CHa-N(CH3> -CHa_' -CHa-NH -（CH山-、-(CHa〉a-N(CHaCH3)-(CH2)3-、 -（CHa)a-1,4-亞苯基- CHa -、-（CHaia-O-lJ-亞苯基 - 、-（CHa)a-0-1,2-亞苯基-CHa-、-(CHa〉a-0-l,4-亞苯基-CHa-、-CH = CH-S-CHa-l,4-亞苯基-CHa-、_CH = CH-S-1,3-亞苯基-(CHa〉a-、2-氧代丙烯基、3-氧代戊烯基、5-氧代 己烯基、亞乙烯基1-亞丙烯基、2-亞丙烯基、卜亞丁烯基 、2-亞丁烯基、3-亞丁烯基、1,2-亞丁二烯基、1,3-亞丁 二烯基、卜亞戊烯基2-亞戊烯基、3-亞戊烯基、4-亞戊燦 基、1,2-亞戊二烯基、1,3_亞戊二烯基、1,4-亞戊二烯基 、2,3-亞戊二烯基、2,4_亞戊二烯基、卜亞己烯基、2一亞 己烯基、3-亞己烯基、4-亞己烯基、5-亞己烯基、1，2-亞 己二烯基、1,3-亞己二烯基、1,4-亞己二烯基、1，5_亞己 二烯基、2,3-亞己二烯基、2,4-亞己二烯基、2,5-亞己二 烯基、3,4-亞己二烯基、3,5_亞己二烯基、4,5-亞己二嫌 基、1，1_二甲基-4-亞己烯基、1-亞庚烯基、2_亞庚嫌基 、3-亞庚烯基、4-亞庚烯基、5-亞庚烯基、2,2-二甲基-5 -亞庚烯基、6-亞庚烯基、1,2-亞庚二烯基、1，3-亞庚一 烯基、1,4-亞庚二烯基、1，5-亞庚二烯基、1，6_亞庚二嫌 基、2,3-亞庚二烯基、2,4-亞庚二烯基、2,5-亞庚二嫌基 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 13 (請先閱讀背面之注意事項本頁) ,τ 513422
Α7 Β7 五、發明説明（10 ) 經濟部中央標準局員工消費合作社印製 2,6-亞庚二烯基、3,4-亞庚二烯基、3,5-亞庚二烯基、3, 6-亞庚二烯基、4,5_亞庚二烯基、4,6-亞庚二烯基、或5, 6-亞庚二烯基、1-亞丙炔基、3-亞丁炔基、2-亞戊炔基、 5-亞己炔基、6-亞庚炔基、-（CHe)-CH = CH-〇-(CH2)a、 -(：1-5-((：112)3-、-(：112-順位-(：1^(：[1-1,2-亞苯基_(：1^-、 -CH = CH-1，4_亞苯基-(CHa)a-、-4-氧代-4, 5-亞己烯基等 〇 「烷基」乃意指匕〜CaD之直鍵狀或分枝狀的烷基， 例如甲基、乙基、正丙基、異丙基、正丁基、異丁基、第 二丁基、第三丁基、正戊基、異戊基、新戊基、第三戊基 、己基、庚基、辛基、壬基、癸基、十一烷基、十二烷基 、十三烷基、十四烷基、十五烷基、十六烷基、十七烷基 、十八烷基、十九烷基、二十烷基等。 「芳基」乃意指Ce〜Ci 4之單環或縮合環，例如苯基 、萘基（例如卜萘基、2-萘基）、蒽基（例如1-M基、2 -蒽基、9-蒽基）、菲基（例如2-菲基、3-菲基、9-菲基） 、笏基（例如2-笏基）等。尤其Μ苯基爲佳。 「芳烷基」乃指前述芳基取代於前述烷基者，此等係 能於可置換之全部位置進行結合。例如，苯甲基、苯乙基 、苯丙基（例如3-苯丙基）、萘甲基（例如α-萘甲基）、 葸甲基（例如9-蒽甲基）、菲甲基（例如3-菲甲基）等。 「醯基」乃意指源自脂肪族羧酸之(^〜(：3的醯綦，例 如甲酿、乙酿、丙酿、丁酿、戊酿等。 「烷基磺酿基」乃指上述烷基於磺醯基上進行取代者 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） (請先閲讀背面之注意事項r -裝-- Τ本頁) 訂 線 14 513422 A 7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（11 ) ，例如甲磺醯基、乙磺酿基、丙磺醯基等。 「烷烯基」乃指於上述烷基上具有1値或1値Μ上之 雙鍵的直鏈或分枝狀的Ca〜caa烷烯；例如乙烯基、1-丙 烯基、2-丙烯基、卜丁烯基、2-丁烯基、3-丁烯基、1,2-丁二烯基、卜戊烯基、1,2-戊二烯基、2-己烯基、1,2-己 二烯基、3-庚烯基、1,5-庚二烯基等。 「烷炔基」乃指於上述烷基上具有1個或1値Μ上之 三鍵的直鐽或分枝狀的Ca〜CaD烷炔基，例如，乙炔基、1 -丙炔基、2-丙炔基、1-丁炔基、2-丁炔基、3-丁炔基等 Ο 「雜環」乃指於環内含有1値Μ上任意選自氧原子、 硫原子及/或気原子，且，亦可與磺環或其他雜環進行縮 合之5〜7員環，此等能夠於可置換的位意位置進行結合 。例如，Bit咯基（例如Ι-Blt咯基、3-吡咯基）、蚓跺基（ 例如2-蚓哚基、3-蚓哚基、6-蚓跺基 >、咔唑基（例如2-咔唑基、3_咔唑基）、眯唑基（例如卜眯唑基、4-眯唑基 )、吡唑基（例如1-吡唑基、3-吡唑基）、苯并眯唑基（ 例如2-苯并眯唑基、5-苯并眯唑基）、||?|跺基（例如3-蚓 哚基 >、蚓跺烷基（例如6-Βζ!跺烷基）、吡啶基（例如2-吡啶基、3-吡啶基、4-吡啶基）、喹啉基（例如8-喹啉基 )、異喹啉基（例如3-異喹啉基）、β丫啶基（例如卜吖啶 基）、菲啶基（例如2-菲啶基、3-菲啶基）、<瞎基（例 如3-述8秦基）、Bit咯烷基（例如4_吡咯烷基）、吡嗪基（ 例如2_吡嗪基）、二氮雜萘基（例如3 —二気雜萘基）、酞 (請先閱讀背面之注意事項丈 -裝-- 乘馬本頁)
、1T -線 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 15 513422 A7 B7 i、發明説明（12 ) 經濟部中央標準局員工消費合作社印製 嗪基（例如5-酞嗪基）、喹唑啉基（例如2-喹唑啉基）、 異噁唑基（例如3-異噁唑基、4-異噁唑基）、苯并異噁唑 基（例如1,2-苯并異噁唑-4-基）、2,1-苯并異嗎唑-3-基 )、噁唑基（例如2-噁唑基、4-噁唑基、5-噁唑基）、苯 并噁唑基（例如2-苯并噁唑基）、苯并噁嗪唑基（例如4-苯并噁嗪唑基）、異睡唑基（例如3-異噻唑基、4-異噻唑 基）、苯并異睡唑基（例如1,2-苯并異噻唑-3-基、2,1 -苯并異睡唑-5-基）、噻唑基（例如2-睡唑基 >、苯并《唑基 (例如2-苯并唾唑基）、噻嗪唑基（例如1,2,3-瞎嗪唑-4 -基）、噁嗪唑基（例如，1,3,4-噁嗪唑-2-基）、二氫蠛 B秦唑基（例如4, 5-二気-1,2,4-曛嗪唑-3-基）、呋喃基（ 例如2-呋喃基、3-呋喃基）、苯并呋喃基（例如3-苯并呋 喃基）、異苯并呋喃基（例如1-異苯并呋喃基）、_盼甲 基（例如2-睡盼甲基、3-噻盼甲基）、苯并噻盼甲基（例 如卜苯并睡盼-2-基、2-睡吩-1-基）、四唑基（例如5-四 睡基）、苯并二噁唑基（例如1，3-苯并二噁唑-5-基）、 二苯并呋喃基（例如2-二苯并呋喃基、3-二苯并呋喃基） 、二苯并噁吡（例如二苯并[b,f]噁吡基-2-基）、二氫二 苯并噁吡基（例如二氫二苯并[b,f]畷吡基）、氧萘基 (例如2H-氧萘-3-基、4H-氧萘-2-基）、二苯并噻吡基（ 例如二苯并[b，f]噻吡-3-基、二氫二苯并[b,f]確吡_3_基 )、嗎啉基（例如1,4-嗎啉-4-基）、盼睡嗪基（例如2-盼噻嗪基）、環五睡盼甲基（例如環五[1>]_盼-3-基）、 環六睡盼甲基（例如環六[b]睡盼-3-基）等。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁)
訂 16 ϋ’:五、 發明説明（13 A7 B7 經濟部中央標準局員工消費合作社印製 〔環烷基〕乃意指C3〜Ce之環狀烷基，例如環丙基、 環丁基、環戊基、環己基等。 「環烷烯基」乃意指C3〜Ce之環狀烷烯基，例如環丙 烯基（例如卜環丙烯基）、環丁烯基（例如，2-環丁烯-1 -基）、環戊烯基（1-環戊烯-1-基）、環己烯基（例如1 -環己烯-1-基）等。 「烷氧基」乃指G〜“的烷氧基，例如甲氧基、乙氧 基、正丙氧基、異丙氧基、正丁氧基等。 「取代或非取代」中之取代胺基乃例如甲胺基、乙胺 基、二甲胺基、環己胺基、苯胺基、二苯胺基等之單或二 取代胺基、哌啶基、吡阱基、嗎啉基等之環狀胺基。 「醯氧基」乃意指從前述之「酿基」所衍生之酿氧基 ，例如乙酿氧基、丙醢氧基、丁酿氧基、戊酿氧基等。 「鹵素」乃意指氟、氯、溴、碘。 「烷氧羰基」乃意指由前述之「烷氧基」所衍生之烷 氧羰基，例如甲氧羰基、乙氧羰基、苯氧羰基等。 「芳烷基氧羰基」乃意指由前述之「芳烷基」所衍生 之芳烷氧羰基，例如甲基氧羰基、苯乙基氧羰基等。 「芳氧羰基」乃意指由前逑之「芳基」所衍生之芳氧 羰基，例如苯氧羰基、萘氧羰基等。 「烷烯氧基」乃意指由前述之「烷烯基」所衍生的烷 烯氧基，例如乙烯氧基、卜丙烯氧基、2_丁烯氧基等。 「羥烷基」乃意指由前述之「烷基」所衍生的羥烷基 ，例如羥甲基、羥乙基、羥丙基等。 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐）
(請先閱讀背面之注意事項V -裝— 1¾本頁) 訂 線 17 513422 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（14 ) 「烷基硫」乃意指由前述之「烷基」所衍生的烷基硫 ，例如甲基硫、乙基硫、丙基硫等。 「烷撐基二氧」乃指由所衍生的「烷撐基二氧 」，例如甲撐二氧、乙撐二氧、丙撐二氧等。 於「亞苯基」、「亞萘基」、「噻吩二基」、「吲哚 二基」、「噁唑二基」、「噁嗪唑二基」、「四唑二基」 中係可在能取代的任意2處與相鄰的基結合。 又，在前逑定義中，取代基為環狀者亦可被選自硝基 、烷氧基、氨磺醯基、取代或非取代胺基、醢基、酿氧基 、羥基、鹵素、烷基、烷炔基、烷氧羰基、芳烷氧羰基、 芳烷氧羰基、甲磺醯氧基、氰基、烷烯氧基、羥烷基、三 氟甲基、烷硫基、-N = PPh3、氧代、硫代、羥亞胺基、烷 氧亞胺基、苯基及烷撐二氧中1〜3個的基所取代，但於 環上中之此等的取代基亦可於能置換的任意進行取代。 通式（I )之化合物的鹽可舉例如鹼金颶鹽（例如鋰鹽 、納馥或鉀鹽等）、驗土族金屬鹽、（例如鈣鹽等）、與 有機驗（例如三甲醇胺基甲烷、三甲胺、三乙胺、2-胺基 値烷、第三丁基胺、二異丙基乙胺、正丁基甲基胺環己胺 、二環己胺、N-異丙基環己胺、糠基胺、苯甲基胺、甲基 苯甲基胺、二苯甲基胺、N,N_二甲基苯甲基胺、2_氯苯甲 基胺、4-甲氧基苯甲基胺、卜亞萘基甲胺、二苯基苯甲基 胺、三苯基胺、1-萘基胺、卜胺基蒽、2-胺基蒽、脫氫松 脂酿胺、N-甲基嗎啉或吡啶）之鹽、或胺基酸鹽（例如賴 胺酸鹽、精胺酸鹽等）。 (請先閱讀背面之注意事項 本百〇 -裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（2l〇X 297公慶） 18
五 • 經濟部中夬標準局員工消費合作社印製 發明説明（15) 水和物乃意指Μ式（I )所示之化合物或其鹽的水和物 ，例如1水和物、2水和物。 本發明化合物係Μ通式（I )所示，且包含其全部的立 體異性體（非鏡像立體異構物、差向立體異構物、鏡像物 等或外消旋髏）。 Μ通式（I >所示之化合物中，a=l之化合物，尤其， 後述之表3b及3c所示的化合物係特開平2-180862說明書中 所記載的公知化合物。 Μ通式（I )所示的化合物中，n=〇之化合物（以通式 (I ’）所示的化合物）係如下逑反應式所示，可藉由使通 式U )所示的胺基化合物與對應於部分構造式Z-Xi-Xa-Xa 的磺酸或羧酸的反應性衍生物進行反應來製造。
QA—R
NH I B (II) ---------裝— 一 i (請先閱讀背面之注意事項^^寫本頁 訂
A—R N—Z — Xr B (I·) (式中，A、B、R、Xt、Χβ、、X3、Y及Z之定義同於前述 )° 對應於部分構造式Z-X1-Xa-X3$磺酸為M通式χ3-Xa-Xi - S〇a〇H所示的化合物。此等磺酸或羧酸之反應性衍生物 乃意指對應的酸鹵化物（例如氯化物、溴化物、碘化物） 、酸無水物（例如與蟻酸或醏酸之混合酸無水物）、'活性 酯（例如，琥珀酿亞胺酯）等，包含使用於一般胺基之酿 化的酿化劑。又，羧酸X3-Xa-Xi-C00H係不限於反應性衍 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 19 線 513422 Α7 Β7 經濟部中央標準局員工消費合作社印製 五、發明説明（16) 生物，亦可於使用在胺與羧酸之縮合反應的縮合劑（例如 二環己基羰二亞酿胺（DCC)、1-乙基-3-(3-二甲基胺基丙 基）羰二亞酿胺、Ν,Ν’-羰基二眯唑）的存在下進行反應。 反應只要依照一般胺基的酿化反應之條件下進行即可 ，例如，Μ酸鹵化物進行縮合反應時，溶劑可使用醚条溶 劑（例如二乙醚、四氫呋喃、1，4_環氧己烷）、苯条溶劑 (例如苯、甲苯、二甲苯）、鹵化碩氫条溶劑（例如二氯 甲烷、二氯乙烷、氯仿）、其他、醋酸乙酯、二甲基甲酿 胺、二甲基亞確I、乙腈等，必要的話，在鹸基（例如三乙 胺、吡啶、Ν，Ν-二甲胺基毗啶、Ν_甲基0馬啉等之有機驗、 或氫氧化鈉、氫氧化鉀、磺酸鉀等之無機鹼）的存在下， 冷卻下乃至室溫或加熱下，較佳係-20t：乃至冰冷下或室 溫乃至反應条的加熱回流溫度，數分鐘乃至數十小時，較 佳係0.5小時乃至24小時，更佳係1小時乃至12小時實施 即可。 卽使於其他之反應性衍生物或游離的酸與胺U)之反 應中，依照各反應性衍生物或游離酸的性質，按公知的方 法，只要決定反應條件即可。 反應生成物係依一般的精製法，例如溶劑萃取、色層 分祈、再結晶法等精製之。 若表示本反應法中之原料化合物（I)的具體例，3-胺 基[2，2, 1]雙環条化合物之具體例可例示7-(3_胺基雙環 [2,2, 1]庚-2-基）_5-庚烯酸、7-(3-胺基雙環[2,2, 1]庚-2 -基〉_2,2-二甲基-5-庚烯酸、7-(Ν-甲基-3-胺基雙環[2,2 (請先閲讀背面之注意事項寫本頁) •裝 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 20 513422 A7 B7 五、發明説明（17 ) 經濟部中央標準局員工消費合作社印製 ,1]庚-2-基）-5-庚烯酸、6-(3-胺基雙環[2,2, 1]庚-2-基） -5-己烯酸等。又，2-胺基-6,6-二甲基[3, 1，1]雙環条化 合物之具體例可例示7-(2-胺基-6,6-二甲基雙環[3, 1,1] 庚-3_基〉-5-庚烯酸等。又，此等原料化合物之庚烯酸鍵 可形成飽和亦可形成庚酸，亦可鏈的中間介入-0-、-S-、 -NH_等之雜原子或雜基或亞苯基，亦可Μ氧代基進行取代 ，可例示如7_(3-胺基雙環[2,2,1]庚-2-基）庚酸、4-[2-( 2-胺基雙環[3,1,1]庚-3-基）乙氧基苯基醋酸，7-(3_胺基 雙環[2,2,1]庚-2-基>-6-氧代庚酸等。此等之原料化合物 係已記載於特公平5-79060號說明書、特公平6-23170號說 明書中，或可依此等說明書之方法而製造。 對應於部分構造式Z-Xi-X3-X3之磺酸X3-Xa-Xi-S〇2〇H 及羧酸X3-X2-Xi-C00H係具有對應於前逑X之取代基的磺酸 或羧酸，亦即，烷磺酸或羧酸、烷烯磺酸或羧酸、烷炔磺 酸或羧酸、環烷磺酸或羧酸、環烷磺酸或羧酸、芳基磺酸 或羧酸、芳烷基氧磺酸或羧酸、雜環取代磺酸或羧酸、雜 芳基烷基磺酸或羧酸、及取代胺基磺酸或羧酸。此等之磺 酸及羧酸可分別具有前述定義之取代基。又，此等磺酸及 羧酸可爲自市售品所得到者，或，從已知的化合物依習知 的方法而很容易合成者。反應之際，此等磺酸及羧酸可依 需要而作為對應之上述反應性衍生物。例如形成酸鹵化物 時，只要依習知的方法（例如新實際化學講座14卷1787頁 (1978) ; Synthesis 852-854 (1986〉；新實驗化學講座 22 卷115頁（1992〉）而與齒化亞硫醯基（例如亞硫酿氯）、 (請先閱讀背面之注意事項再_馬本頁) •裝-
、1T 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 21 513422 A 7 B7 五、發明説明（18 ) 鹵化磷（例如三氯化磷、五氯化磷）、鹵化草醯基（例如 乙二酿氯）等反應即可。有關其他之反應性衍生物同樣地 亦可Μ公知的方法調製。 本發明目的化合物（I )之中，侧鐽Α乃具有不飽和鍵 ，尤其雙鍵之化合物係可使對應於侧鋪A-R部分之殘餘部 分的環烯化合物依Witt ig反應的條件與Μ下述通式（M)所 示之醛衍生物反應而製造之。
(式中，A、B、R、Xi、Xa、Χ3、Υ及Ζ之定義同於前述） 〇 原料化合物（I〉可依例如記載於特開平2-256650號說 明書之方法製造。又，對應於側鏈AR部分之殘餘部分的環 烯化合物係可在鹼的存在下依公知的方法使對應的鹵化烷 酸或其酯衍生物、醚衍生物、醯胺衍生物等與三苯基滕進 行反應而合成之。 經濟部中央標準局員工消費合作社印製 (請先閲讀背面之注意事項本頁) 於本發明目的化合物（I )中，R為C00H之化合物亦可 依所希望的形成對應之酯衍生物、醇衍生物、醚衍生物、 酿胺衍生物。例如酯衍生物係可依公知的方法藉由酯化以 製造羧酸。又，若還原酯衍生物，可形成醇衍生物，若進 行酿胺化亦可形成酿胺衍生物。醚衍生物亦可藉由0-烷基 化而製造醇衍生物。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 22 513422 Α7 Β7 經濟部中央標隼局員工消費合作社印製 五、發明説明（19 ) 本發明之化合物（I〉係表示藉由Μ活體外與PGD2受容 體結合之卩603拮抗作用，可用來作為起因於PGDat生產過 多的肥胖機能不全相關的疾病治療劑。例如可用來作爲全 身性肥胖細胞症或全身性肥胖細胞活性化障礙的治療劑、 抗氣管收縮劑、抗喘息劑、抗過敏性鼻炎劑、抗過敏性結 膜炎劑、抗尊麻疹劑、缺血再灌流傷害治療劑、抗炎症劑 。尤其，本發明化合物（I )係Μ活體内顯示鼻塞抑制作用 ，故可作為鼻塞症之治療劑。 將本發明之化合物（I)用於治療時，可調製成為一般 經口或非經口投與用的製劑。含有本發明之化合物（I)之 醫藥組成物可採用用Μ經口及非經口投與之劑形。亦卽，亦 可形成錠劑、膠囊劑、顆粒劑、散劑、糖漿劑等之經口投 與製劑、或、靜脈注射、筋肉注射、皮下注射等之注射用 溶液或懸濁液、吸入藥、點眼藥、點鼻藥、痤劑、或、軟 膏劑等之經皮投與用製劑等的非經口製劑。 此等製劑可使用從事此業者已知之適當擔體、賦形劑 、溶劑、基劑等來製造。例如，錠劑時，可使活性成分與 補助成分一起壓縮或成型。補助成分係可使用製劑上所容 許之賦形劑、例如結合劑（例如玉蜀黍澱粉）、充瑱劑（ 例乳糖、微結晶性绻維素）、崩壊劑（例如澱粉葡萄糖酸 鈉）或滑澤劑（例硬脂酸鎂）等。錠劑亦可適當被覆。糖 漿劑、液劑、懸濁劑等之液體製劑時，例如使用懸濁化劑 (例甲基纖維素）、乳化劑（例外源凝集素）、保存劑等 。注射用製劑時，可為溶液、懸濁液或油性或水性乳濁液 (請先閱讀背面之注意事項ν •裝-- 零舄本頁) 、1Τ 線 本紙張尺度適用中國國家標準（CNS ) Α4規格（210 X 297公釐） 23 2 A7 B7 五 、發明説明（20 ) 之形態，此等亦可含有懸濁安定劑或分散劑等。使用來作 為吸入劑時，可用來作為能適應於吸入器之液劑，使用來 作為點眼劑時亦可用來作為液劑或懸濁劑。尤其使用來作 為一用以治療鼻塞症之點鼻藥時，依一般製劑化的方法， 可使用來作為液劑、懸濁化劑，或，粉末化劑（例如羥丙 基纖維素、卡巴波爾）等，加入鼻孔作為粉末劑。或，充 填低沸點之溶劑及特殊的容器中，可使用來作為噴射劑。 化合物（I)之投與量依據投與形態、患者年齡、體重 、性別、或所併用的藥物（若有的話）等而異，最終仍委 由翳師的判斷，但，經口投與時，體重每lkg為1日0.01 〜100mg，宜為0·01〜l〇mg，更宜為0.1〜l〇mg，非經口投 與時，髏重每lkg為1日0·001〜lOOing，宜為0.001〜lmg ，更宜為0·01〜lmg。只要將此分開成1〜4次投藥卽可。 Μ下舉實施例詳細說明本發明，此等僅為例示，本發 明並非限制於此等。 實施例1 彳 (請t閲讀背f之注意事項^^寫本頁) 裝· 訂 cooch3 經濟部中央標準局員工消費合作社印製 (la-2)
/NHS〇2— (la-1)
^^vNHS〇2 —(ry^〇 (la-3)
気氣流下，使（2)-7-[(15,211,311,411卜3_胺基雙環[2, 2，1]庚-2-基]-5-庚烯酸甲酯 U -l)(251mg , l.OOnifflol)溶 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 24 513422 A7 B7 五、發明説明（21 經濟部中央標準局員工消費合作社印製 解於二氯甲烷（8ml)，加入三乙胺（〇.238ml、2. OOmmol)後 ，冰冷下，加入2-氯磺醯基二苯并呋喃（350mg, 1,31hnb〇1 )，攪拌30分鐘，昇溫至室溫。反應液Μ矽凝膠管柱色層 分析（正己烷、醋酸乙酯1:4)精製，從正己烷（l〇ml)結 晶化，得到（Z)-7-[(1S，2R,3R,4R)_3-(2-二苯并呋喃基） 磺醢基胺基雙環[2,2,1]庚-2-基]-5-庚烯酸甲酯（la-1) (342ing，0·710ππβο1)。收率 71%。 融點：115-116= 元素分析（C 27Η 31Ν〇5 S ) 計算値（％) ： C,67.34;H,6.49;N,2.91;S,6.66 實測値（％) ： C,67.16;H,6.47;N,2.99;S ,6.66 IR (CHC13) ： 3382,3024,2952,2874,1726,1583,1465,1442,1319,1245,1154 ,1121,1104,1071,1019,890,840,817 /cm。 1H NMR(CDC13) δ : 0.94-1.92(14H,m),2.15-2.24(3H,m),2.99.3.07(lH,m), 3.66(3H,s),4.98(lH,d,J=6.6Hz)，5.10-5.22(2H，m),7.39-7.46(lH,m)，7.51-7 .70(3H，m)，7.87-8.13(2H，m),8.53(lH，d,J=2.lHz)。 [ct]D = -0.6〇 (ΟΗα3,ο=1·01%,23ΐ)· ([α]365 = +37·0β (CHC13，c=1.01%,23t：)· 使（Z)-7-[(15,21311,41〇-3-(2-二苯并呋喃基>磺酿 基胺基雙環[2,2,1]庚-2_基]-5 -庚稀酸甲醋（la-1) (234mg ，0·50πιιβο1)溶解於甲醇（6ml〉_四氫呋喃（4·1>，冰冷下， 加入IN氫氧化鉀（1.50ml，1.50fflmol〉後，昇溫至室溫，反 應16小時。餾去溶劑後，於殘渣中加入酯酸乙酯（5〇ml)與 水（10ml)，進而加入1N鹽酸（2· 00ml，2. OOfflol)，分取有 機層後，以飽和食鹽水洗淨有機層後，Μ無水硫酸鈉乾燥 。餾去溶劑後，殘渣Μ矽凝膠管柱色層分析（正己烷、
(請先閲讀背面之注意事項V 裝-- r本頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 25 - 513422 A7 B7 五、發明説明（22 經濟部中央標準局員工消費合作社印製 酸乙酯=1 ·· 1，0.2%醋酸）精製，得到（Z)-7_[(1S,2R, 3R,4R〉_3-(2_二苯并呋喃基〉磺醯基胺基雙環[2,2, 1]庚-2 -基]-5-庚烯酸（la-2> (203mg，0.434mniol)。收率 87%。 油 IR (CHC13) : 3266,3026,2952,2874,1708,1465,1443,1423,1319,1267,1245 ，1153，1121,1104,1072,906 /cm。 1H NMR(CDC13) δ : 0.93-1.94(14H,m),2.12-2.19(lH,in),2.26(2H,t,J=7.2H z),3.00-3.08(lH,m),5.12.5.25(2H,m),5.26(lHfd,J=6.6Hz),7.38-7.45(lH,m),7.51-7.70(3H,m),7.87-8.13(2H,m),8.54(lH,d,J=2.lHz)。 [a]D = +6.8〇 (CHC13,c=1.08%,23t：)e 將（Z)-7-[(lS，2R,3R,4R)-3-<2-二苯并呋喃基）磺醢 胺基雙環[2,2, 1]庚 基]-5-庚烯酸（la-2) (453mg，0.97 mmol〉溶解於甲醇（5ml)中，冰冷下加入IN甲氧基鈉/甲醇 溶液（1.034當量，0.937ml，0.97inmol)後，昇溫至室溫， 反應1小時。餾去溶劑，而得到鈉鹽（la-3) (457mg，0.933 mmo 1)。收率 96%。 無晶狀粉末 元素分析（C26H28N〇5SNa.0.6H2〇） 、. 計算値（％) : C,62.41;H,5.88;N,2.80;S,6.41;N a ,4.59 實測値（％) : C,62.45;H,5.92;N,2.99;S ,6.49;N a ,4.46 IR (KBr) : 3434,3280,3074,3007,2952,2873,1566,1467,1444,1417,1344,1 315,1270,1248,1200,1189,1154,1124,1107,1075,1058,895,842,818 /cm。 1H NMR(CD30D) δ : 1.02.2.05(16H,m),2.16.2.23(lH,m),2.94-3.00(lH,m), 4.98-5.05(2H,m),7.41.7.48(lH,m),7.53.7.62(lH,m),7.66(lH,d,J=8.4Hz),7 • 77(lH,d，J=8.4Hz),8.57(lH,d,J=2.1Hz)。 [a]D = -15.2〇 (CH3OH,c=1.07%,22r)e 實施例2 (請先閲讀背面之注意事項本頁) 裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 26 五、 發明説明（ 23
COOCH3 3COOH (II-2) A7 B7 COOCH3 ^vNHCO—(3^^0 (lk-11) cooh ^vNHCO —<Q)~ 經濟部中央標準局員工消費合作社印製 (lk-12) 將（2>-7-[(15,211,31^41〇-3-胺基雙環[2,2,1]庚-2-基]-5-庚烯酸甲酯三氟醋酸鹽（I -2)(依據特公平5 -79060號、參考例而製得）232mg(0.636mmol)溶解於二氯 甲烷（5ml〉中，冰冷下加入三乙胺〇.279ml(2.0ffiniol)與4-雙苯基羰基氯，在同室溫下攪拌7小時。Μ矽凝膠管柱色 層分析（醋酸乙酯：己烷=1 : 4)精製反應液，得到（Ζ) -7-[(15,28,31^41〇-3-(4-雙苯基）羰基胺基雙環[2,2,1]庚 -2-基]-5-庚烯酸甲酯（11(-11)221料（0.512111111〇1>〇將此化 合物（lK-ll)(190mg，0.440mBiol)溶解於甲醇（6nl)中，冰 冷下加入IN K0H(1. 10ml，1· lOmmol)，在室溫下攪拌15小 時。減壓下濃縮反應液後，於殘渣中加入水（20ml)與1N HCl(2ml>，Μ醋酸乙酯萃取。有機層K飽和食鹽水洗淨後 ，以硫酸鈉乾燥後，濃縮。殘渣Μ矽凝膠管柱色層分析（ 醋酸乙酯：己烷=1: 1) (〇·3%醋酸）精製而得到<Ζ) - 7 _[(lS,2R,3R,4R)-3-(4-雙苯基）羰基胺基雙環[2,2, 1]庚-2-基]-5-庚烯酸（1K-I2)172iag(0.412ffimol)。收率 94%。 下述所示之化合物亦可Μ如下的方法來製造。 實施例3 、CH〇 __ vNHS02-^ (III-l)
_CO〇- 1/2Ca2+ ，NHS02^Q (3d-l) 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） (請先閱讀背面之注意事項r 裝-- 冒寫本頁) 、11 線 27 經濟部中夬標隼局員工消f合作社印¾ 513422 第85107425號專利申請案 H2 γ 說明書修正頁91年9月27日 Α7 五、發明説明（24) 氮氣氛下，於一由4-浚基丁基三苯基搽溴（14. 8g， 33.3〇111〇1)收回氬呋喃（8〇11)所構成之懸濁液中以室溫加 入第三丁基鉀（7.55g，67.3·βο1)。直接Μ室溫«拌1小 時後，冷郤至-201C而徐缓加入卜[(15,25.35.41〇-3-甲醒 基甲基雙環[2\2, 1]庚-2-基]苯磺醢胺U -1)(持開平2- 256650號、參考例2)(3.25g，ll.liaol)之四氳呋喃溶液 (20ml〉。在-20t：下雄繙魇拌1小時半後，除去冰浴，進 而再漫拌1小時。於反應蔽中加入2N鹽酸，以賭酸乙酯萃 取，以水及食邇水洗淨獯缩。於所得到之粗生成物中加入 甲苯與1N氳氧化納溶液而分取水層。有機層再一次水洗淨 ，合併先前之水層後，加入2N鹽睃。以賭酸乙酯萃取後， 以水及食鹽水洗淨，以硫酸卞乾燥後獾缩。殘渣K矽凝膠 管柱色層分析精裂，得到（Z)-7-[(lR,2S,3S,4S)-3-苯基 磺S基胺基雙環[2,2,1]庚-2-基]-5-庚烯酸鈣（3d-l〇 (3.29g ，收率 7996 )。 ®a：6 2X： 元紊分祈（C 20 Η 27 NO 4 S ) 計算値（％):C· 6 3.6 3;H, 7.2 1;N, 3.7 1；S, 8.4 9 S测値（％):C· 6 3.5 6;Η· 7.2 1;N, 3.8 3;S，8.4 3 · [〇：】D=+5.3±0.5*(CHCl3.C=1.003%，22t：) [a]D=+27.1±0.7*(MeOH,C=1.0 15%.24t：) IR(Nujol) 3282. 3260, 3300. 2400, 1708. 1268. 1248. 1202. 1162. 1153, 1095. 1076/cm 1HNMR δ 0.88-2.10(m, 14H), 2.14(brs, 1H)· 2.34(t. J=7.2Hz. 2H). 2.95-3.07(m. 1H). 5.13-5.35(m. 3H). 7.45—7.64(m. 3H), 7.35-7.94(m. 2H), 9.52(brs· 1H) 與上述實施例同樣地做法而製得之化合物表示於下。- 本紙朵尺度逋用中國國家標率（CNS ) Α4規格（210Χ297公釐） i - ' - I 丨丨 - I - - i I I I (請先閱讀背ώ之注意事項再填寫本頁) 訂 28 513422 A7 B7 五、發明説明（25 ) 表1 a
No. 經濟部中央標準局員工消費合作社印製
la-1 ch3 la-2 H la-3 Na la-4 ch3 la-5 H la-6 ch3 la-7 H la-8 ch3 la-9 H la-10 ch3 la-11 H la-12 la-13 ch3 la-14 ch3 la-15 H la-16 ch3 la-17 H la-18 ch3 la-19 H la-20 ch3 la-21 H la-22 H la-23 H
cf3 /SO2NH2
och3
och3 (請先閱讀背面之注意事項再填_，頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 29 513422 A7 B7 五、發明説明（26 )
COORi NS02—X1-X2-X3 Η
No. la-24 la-25 la-26 la-27 la-28 la-29 la-30 la-31 la-32 la-33 經濟部中央標準局員工消費合作社印製 la-34 la-35 la-36 la-37 la-38 la-39 la-40 la-41 la-42 la-43 la-44 la-45
CH3 H Na CH3 H Na CH3 H CH3 H CH3 ch3 H ch3 H CH3 H
CH3 H CH3 H 、丨厂一 -N=N- 〇Ac (請先閱讀背面之注意事項再本頁) -裝- -N=N- -N=CH- >-CH=CH2
OCH3 —^^CH2CH2^^ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
OH 訂 30 513422 A7 B7 五、發明説明（27
No. XJ-X2-X3 la-46 la-47 la-48 la-49 la-50 la-51 la-52 la-53 la-54 la-55 la-56 la-57 la-58
CH3 H Na CH3 H CH3 H CH3 H CH3 H CH3 H N〇2 nh2
請 先 閱 讀 背 之 注 意 事 項 本 頁 裝 訂 經濟部中央標準局員工消費合作社印製 la-59 la-60 la-61 la-62 la-63 la-64 la-65 la-66 la-67 la-68
CH3 H ch3 H CH3 H ch3 H CH3 H —(CH2)5CH3 ht 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 31 513422 A 7 B7 五、發明説明（28 )
經濟部中央標準局員工消費合作社印製 la-69 la-70 ch3 H la-71 la-72 ch3 H la-73 la-74 ch3 H -〇-〇Ac la-75 la-76 ch3 H -Qr^ -^^•COOR1 la-77 la-78 ch3 H ~^C5^n〇2 la-79 H "〇-〇CH3 la-80 la-81 ch3 H -p N〇2 la-82 la-83 ch3 H -o- nh2 la-84 H no2 ~{^〇ch3 la-85 H nh2 O"0CH3 la-86 H N〇2 〇^0H la-87 H ο·0Η nh2 (請先閱讀背面之注意事項冩本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 32 513422 A7 B7 五、發明説明（29
No.
XrXrX3 la-88 la-89 la-90 la-91 la-92 la-93 la-94 la-95 la-96 la-97
CH3 H CH3 H CH3 H 經濟部中央標準局員工消費合作社印製 la-98 la-99 H Na ^〇^n-chQkno2 Η
,och3 /)^〇ch2 och3 (請先閲讀背面之注意事項再ΙΡτ本頁) •裝· 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 33 513422 A7 B7 五、發明説明（30 )
No. Ri XrX2-X3 經濟部中央標準局員工消費合作社印製 la-100 la-101 la-102 la-103 la-104 la-105 la-106 la-107 la-108 la-109 la-110 la-111 la-112 la-113 la-114
(請先閱讀背面之注意事項本頁) -裝_ 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 34 513422 Μ B7 五、發明説明（31 )
No. Ri X1-X2-X3 la-115 la-116 la-117 la-118 la-119 la-120 la-121 la-122 la-123 la-124 la-125 la-126 la-127 la-128 la-129 la-130 la-131 la-132 la-133 la-134 經濟部中央標準局員工消費合作社印製 la-135 la-136 la-137 la-138 la-139 la-140 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐）
(請先閱讀背面之注意事項v 裝-- 專舄本頁) 訂 線 35 513422 A7 B7 五、發明説明（32)
No. Ri XrX2-X3 經濟部中央標準局員工消費合作社印製 la-141 ch3 la-142 H NC^ la-143 H Ulo /=\ N〇2 la-144 H la-145 H ,Νχ la-146 H /=\ 〇CH3 la-147 H /=x 〇CH3 la-148 H och3 la-149 H V1 -〇iH la-150 H 9 〇Ac la-151 H 〇ch3 (請先閱讀背面之注意事項r •裝-- f本頁) 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 36 513422 A7 B7 五、發明説明（33
No. ΧΓΧ2-Χ3 la-152 la-153 la-154
(請先閱讀背面之注意事項 本頁) 裝- 訂 la-155 la-156 七 la-157
線 la-158 經濟部中央標準局員工消費合作社印製 la-159 la-160
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 37 513422 A7 B7 五、發明説明（34
No. ΧΓΧ2-Χ3 經濟部中央標準局員工消費合作社印製 la-161 la-162 la-163 la-164 la-165 la-166 la-167 la-168 la-169 la-170 la-171 la-172 CH30, C2H50,
(請先閱讀背面之注意事項 巧本百〇 -裝· 訂 線
ch3 H 〇CH3
本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 38 513422 A7 B7 五、發明説明（35
No. xrx2-x3 la-173 la-174 la-175 la-176 la-177 la-178 la-179 la-180
CH3 H CH3 H CH3 H la-181 經濟部中央標準局員工消費合作社印製 la-182 la-183
CH3 H
(請先閱讀背面之注意事項本頁) 裝-
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 39 513422 A7 B7 五、發明説明（36)
經濟部中央標準局員工消費合作社印製
No. Rl xrx2-x3 la-184 H la-185 H la-186 la-187 ch3 H ch3 la-18S la-189 ch3 H ^^X^C〇〇R1 la-190 ch3 la-191 H COOR, la-192 ch3 la-193 H COORi (請先閱讀背面之注意事項再IPr本頁) .裝-
、1T 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 40 513422 A7 B7 五、發明説明（37
No. ΧΓΧ2-Χ3 la-194 CH30
(請先閲讀背面之注意事項v la-195 la-196 la-197 la-198 la-199
CH30, 裝-- 澤舄本頁) la-200 la-0201 經濟部中央標準局員工消費合作社印製 la-202 la-203 CH30
k 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 41 513422 A7 B7 五、發明説明（38
ΧΓΧ2-Χ3 CH30 la-204
-N=N -o la-205 CH30. (請先閲讀背面之注意事項再本頁)
la-206 la-207
、1T la-208 la-209 la-210 la-211 經濟部中央標準局員工消費合作社印製 la-212 la-213
本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 42 513422 A7 B7 五、發明説明（39
la-214 CH30 o la-215 la-216 la-217 la-218 och3
(請先閱讀背面冬注意事項本頁) -裝· 訂 la-219 ch3o. 線 la-220 經濟部中央標準局員工消費合作社印製 la-221 la-222 la-223 -Oh %-
Cl /)CH3 -och3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 43 513422 A7 B7 五、發明説明（4Q )
χΓχ2-χ3 ch3o la-224 CH3 la-225 o2n la-226 ch3o
—o la-227 CH3o 〇ch3 la-228 CH3o. h2n CH3o. la-229 la-230 la-231 la-232 nh2
經濟部中央標準局員工消費合作社印製 la-233 la-234 la-235
,CI
〇 N〇2 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 44 513422 A7 B7 五、發明説明（41 )
COOH >so2—xrx2-x3 Η
No.
XrXrX3 la-236 .och3 OCH3 la-237 la-238
OCH3 (請先閱讀背面之注意事項 本頁) -裝· la-239 la-240
/〇ch3 -och3 訂 la-241 la-242 la-243 CH3o CH3q CH3o —( CH3o'
Ν-δ-
〇 OCH3 OCH3 k 經濟部中央標準局員工消費合作社印製 la-244 la-245 la-246 \\ /r^c\^~0CH2 ~och3 一 〇 _/〇CH3 一〇CH3 CH3、〇ch3 ch3〇
«I
,〇ch3 〇ch3 〇ch3 ,〇ch3 〇ch3 〇ch3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 45 513422 A7 B7 五、發明説明（42
COOHpso2—χΓχ2·χ3 Η X]-X2~X3 CH30 la-247
•C~N
,OCH3 OCH3 〇ch3 CH30 la-248
-C_N CH30, la-249 ch3o la-250 〇 0CH3 ^0CH3 (請先閱讀背面之注意事項再-Jill本百〇 燊' ch3o OCH3 la-251 CH3o 〇 OCH3 OCH3 、\呑 r la-252 la-253 〇CH3 ch3o^ och3 -O-hS^ 0CH3 CH3o 〇 0CH3 〇ch3 i la-254 經濟部中央標準局員工消費合作社印製 la-255 la-256 la-257 CH3 ^ch3
ch3 ch3 ch3 ~θ~ΰ"Η^Ϊ^〇αΗ3 CH3(-oh
0CH3 0CH3 0CH3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 46 513422 A7 B7 五、發明説明（43 )
xrxrx3 經濟部中央標準局員工消費合作社印製 la-258 la-259 la-260 la-261 la-262 la-263 la-264 la-265 la-266 la-267 la-268 la-269 la-270 la-271 CH30,
~^·°Ό och3
-^^nh-^^och3 CHoO
本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) |裝· 太 、11 47 513422 A7 B7 五、發明説明（44 )
No. xrxrx3 經濟部中央標準局員工消費合作社印製 la-272 la-273 la-274 la-275 la-276 la-277 la-278 la-279 la-280 la-281 la-232 la-283 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
48 513422 A7 B7 五、發明説明（45 )
No.
XrX2-X3 la-284 la-285
CH30
CH30, la-286
〇- — I;--J-----^-- (，請先閱讀背面之注意事項再 本頁) la-287 CH30,
NH la-288 CH30, CH30乂
訂 la-289
n，ch3 ch3o, la-290 S02
CH3o, %; la-291 經濟部中央標準局員工消費合作社印製 CH3o,
la-292 la-293 la-294
CH3o,
CH30,
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 49 513422 A7 B7 五、發明説明（46)
No. xrxrx3 la-295 la-296
la-297 la-293 la-299 la-300
(請先閱讀背面之注意事項再本頁) .裝- 訂 la-301 la-302 經濟部中央標準局員工消費合作社印製 la-303 la-304 la-305
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 50 513422 A7 B7 五、發明説明（47 )
ch3 經濟部中央標準局員工消費合作社印製 lb-1 lb-2 lb-3 lb-4 lb-5 lb-6 lb-7 lb-8 lb-9 lb-10 ch3 Η ch3o
ch3o
ch3o *ch2 o
(請先閱讀背面之注意事項V 裝-- f本頁) 、-?口 ch3o
ch3o ch2 ch3o
本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） -51 - 513422 A7 五、發明説明（48 )
No._Ri_ ΧγΧ2-Χ3 lb-11 η
O OCH3 lb-12 Η lb-13 „ -C~N~^ ^~QCH3 ^och3 0 y0CH3~0^OCH3 CH3o
0-N CH30、
OCH3 ^-och3 k〇CH3 (請先閱讀背面之注意事項本頁) 裝· 訂
lb-14 H 〇
lb-15 H 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 52 513422 A7 B7 五、發明説明（49 表lc
No.
XrXrX3 lc-1 lc-2 lc-3 lc-4 lc-5 lc-6
ch3 ch3 K 0 /0CH3一^}(^-〇CH3 ~OCH3 (請先閱讀背面之注意事項 α本頁) lc-7 CH3o
lc-8 Ό^°Ό lc-9 經濟部中央標準局員工消費合作社印製 lc-10 lc-11 lc-12
CH30 OCH3 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 53 513422 A7 B7 五、發明説明（50 )
ld-l ld-2 ld-3 ld-4 ld-5 H S02CH3 Η H H OH H SO2CH3 H SO2CH3 ν/~Ν=ΝΗ〇 ld-6 H S02CH3
ld-7 H SO2CH3 CH30 -ch2-〇 ld-8 H S02CH3 CH30
ch2 ld-9 H SO2CH3 經濟部中央標準局員工消費合作社印製 ld-10 H SO2CH3
o 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 54 513422 A7 B7 五、發明説明（51
No. R3 R4 xrxrx3 ld-11 H SO2CH3
/==\ 〇 / \ II OCH3 〇ch3 (請先閱讀背面之注意事項本頁) •裝_ ld-12 Η S02CH3 OCH3 Ο /=/ -QtHrQt 〇ch3 訂 ld-13 η S02CH3 CH30
〇ch3 ^-〇ch3 och3 ld-14 h S02CH3 CH30\ 0 ld-15 H S02CH3 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 55 513422 A7 B7 五、發明説明（52 表le
No. X「XrX3 le-l le-2
(請先閱讀背面之注意事項^^一舄本頁) •裝_ le-3 le-4 le-5 〇 /=<0CH3 、〇ch3 訂 le-6 ch3o
線 le-7 經濟部中央標準局員工消費合作社印製 le-8 le-9 lc-10
CH30 〇CH3 CH30、 OCHn 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 56 513422 A7 B7 五、發明説明（53 表1
No. R2 ΧΓΧ2-Χ3 1Μ lf-2
(請先閱讀背面之注意事項r •裝--層舄本頁) lf-3 lf-4 lf-5
-C-N
〇CH3 h〇CH3 〇CH3 訂 CH30 lf-6 lf-7 CH30
CH2 經濟部中央標準局員工消費合作社印製 lf-8 lf.9 lf-10 CH30
CH30 CH30、 • Li I— 1!»·- 〇 /0CH3 〇CH3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 57 513422 A7 B7 五、發明説明（％ ) 經濟部中央標準局員工消費合作社印製
，V/N-S02-XrX2.X3 No. R! X1-X2-X3 lg-1 H lg-2 H u CH3o lg-3 H HU lg-4 H ,0^0 lg-5 H ， 0CH3 ~hC^^'h~hC^och3 lg-6 H \)CH3 ch3o ^1 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 58 513422 Α7Β7 五、發明説明（55 表Ih
ΧΓΧ2-Χ3 lh-1 Η
請 λ 閲 讀 背 面 之 注 意 事 項 再 lh-2 Η 頁 lh-3 Η lh-4
H OCH3 och3 \)CH3 lh-5
H ch3o
lh-6
H lh-7
H ch3o
ch2 經濟部中央標準局員工消費合作社印製 lh-8 lh-9 lh-10
H
H
H ch3o
CH3o OCH3"^D^6'h"^^OCH3 och3 CH3o. 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 59 513422 A7 B7 經濟部中央標準局員工消費合作社印製
513422 A7 B7 五、發明説明（57 表1 j
No. X1-X2-X3 (請先閱讀背面之注意事項v ij-i lj-2 lj-3 1H ij-5 lj-6 11-7
CH3 H Na H ch3 ch3 H -裝--零舄本頁) lj-8 CH, lj-9 lj-l〇 lj-11 lj-12
CH3 H CH3 H 經濟部中央標準局員工消費合作社印製 lj-13 lj-14 lj-15 lj-16
CH3 H CH3 H
訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X29?公釐） 61 513422 A7 B7 五、發明説明（58
οι 2 2 1J-1J-
3 CHH
(請先閱讀背面之注意事項舄本頁) •裝· 訂 Η
h3
II
3 3 η*η ^ Η c C 經濟部中央標準局員工消費合作社印製 Η η3χ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 62 513422 A7 B7 經濟部中央標準局員工消費合作社印製
513422 A7 B7 五、發明説明（60 ) 表Ik
No. X1-X2-X3 (請t閲讀背面之注意事項 經濟部中央標準局員工消費合作社印製 lk-l H -〇'CH2-〇 lk-2 lk-3 ch3 H lk-4 H —ΟΌ lk-5 H lk-6 H -〇 lk-7 H lk-8 H lk-9 H lk-10 H lk-11 ch3 oo lk-12 H 00 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 64 513422 A7 B7 五、發明説明（61 )
No.
XrXrX3 lk-13 Η lk-14
H 一<Q)-N=NH^-〇CH3 ch3o、 (請先閱讀背面之注意事項本頁) .裝· lk-15
H lk-16
H
lk-17 H
訂 lk-18
H 線 經濟部中央標準局員工消費合作社印製 lk-19 h
lk-20 H ~och3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 65 513422 A7 B7 五、發明説明（62 ) 表lm -口-CO - xrx2-x3 經濟部中央標準局員工消費合作社印製
No. Rl XrX2-X3 lm-l lm-2 ch3 H lm-3 lm-4 ch3 H lm-5 lm-6 ch3 H —Q-n=n-^> lm-7 lm-8 ch3 H lm-9 lm-10 ch3 H ^〇""〇-<0^〇Ac lra-11 lm-12 ch3 H lm-13 lm-14 ch3 H lm-15 ch3 lm-16 H ~\jr\jr0kz lm-17 ch3 f=\ r=\ lm-18 H -ν/Λ>0Η (請先閱讀背面之注意事項本頁)
、1T 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 66 513422 A7 B7 經濟部中央標準局員工消費合作社印製
513422 A7 B7 經濟部中央標準局員工消費合作社印製
本紙張尺度適用中國國家標準（CNS)A4規格（21〇X29_) 513422 A7 B7 五、發明説明（65 表2a
No.
XrX2-X3 2a-l 2a-2 2a-3 2aM 2a-5 2a-6 2a-7 2a-8 2a-9
CH3 H CH3 H Na CH3 H CH3 H
CHO --.--η-----裝-- (請先閱讀背面之注意事項舄本頁) 2a-10 2a-ll 2a-12 2a-13 CH3 H CH3
、1T 2a-14 2a-15 經濟部中央標準局員工消費合作社印製 2a-16 2a-17 2a-18 2a-19 2a-20 2a-21 2a-22 2a-23 2a-24 CH3 H CH3 H CH3 H CH3 H Na
CH3 H
本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 69 513422 A7 B7 五、發明説明（66
No. X1-X2-X3 2a-25 2a-26 2a-27 2a-28 2a-29 2a-30
CH3 H CH3 H CH3 H -〇H2-^〇 經濟部中央標準局員工消費合作社印製 2a-31 2a-32 2a-33 2a-34 2a-35 2a-36 2a-37 2a-38 2a-39 2a-40 2a-41 2a-42 2a-43 2a-44 2a-45 2a-46 2a-47
CH3 ch3 H CH3 H CH3 H CH3 H CH3 H CH3 H CH3 H CH3 H
N 一〇H
〇 o s ------j-----裝-- (請先閱讀背面之注意事項^^馬本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 70 513422 A7 B7 經濟部中央標準局員工消費合作社印裝
513422 A7 B7 五、發明説明（68
No. ΧΓΧ2-Χ3 經濟部中央標準局員工消費合作社印製 2a-68 2a-69 2a-70 2a-71 2a-72 2a-73 2a-74 2a-75 2a-76 2a-77 2a-78 2a-79 2a-80 2a-81 2a-82 2a-83 2a-84 2a-85 2a-86 2a-87
CH3 H
CH3 H CH3 H CH3 H ch3 H CH3 H CH3 H CH3 H CH3 H CH3 H
-OAc -〇CH3 ~C^〇AC ~^^-〇ch3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 72 _ 7 0 513422 A7 B7 經濟部中央標準局員工消費合作社印製
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） -73 - 513422 A7 B7 五、發明説明（70
No. X1-X2-X3 2a-113 2a-114
ch3 H -cf3 經濟部中央標準局員工消費合作社印製 2a-115 2a-116 2a-117 2a-118 2a-119 2a-120 2a-121 2a-122 2a-123 2a-124 2a-125
CH3 H CH3 H '0 OAc OH OCH3-o
(請先閱讀背面之注意事項寫本頁) •裝- 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 74 513422 A7 B7 五、發明説明（71)
No. 2a-126 2a-127 2a-128
-On~O^N 人 N^O Η H-K-O (請先閱讀背面之注意事項本頁) •裝· 2a-129 2a-130
訂 2a-131
Q 2a-132 2a-133 經濟部中央標準局員工消費合作社印製 2a-134 2a-135 2a-136 -CH2
°O 0
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 75 513422 A7 B7 五、發明説明（72
No.
XrX2-X3 2a-137 2a-138 H —^-〇H〇HOCH(CH3)2 (請先閱讀背面之注意事項寫本頁) .裝_ 2a-139 ίΓ 2a-140
訂
sch3 經濟部中央標準局員工消費合作社印製 2a-141 2a-142 2a-143 2a-144 2a-145 2a-146 2a-147 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 76 513422 A7 B7 五、發明説明（73 COORi *NHCOXrXrX3
No. 2a-148 2a-149 xrx2-x3-*〇 2a-150 2a-151
V 2a-152 h3c、 2a-153 2a-154 2a-155 2a-156 -a> 經濟部中央標準局員工消費合作社印裝 2a-157 2a-158 2a-159 H3C〆 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 77 513422 A7 B7 經濟部中央標準局員工消費合作社印製
請 閱 · 讀 背 面 * 之 注 意 事 項
訂 513422 A7 B7 經濟部中央標隼局員工消費合作社印製
-79 - 513422 A7 B7 五、發明説明（76
No. XPX2-X3 2a-183 2a-184 2a-185 2a-186
2a-187 H3C〇
2a-188 2a-189 2a-190 經濟部中央標準局員工消費合作社印製 2a-191 2a-192 2a-193 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） CH3 C2H5 N Ac * 80
513422 A7B7 五、發明説明（77 ) 'COOR! ¥NHCOXrX2-x3
No. 2a-194 2a-195 H H3C’、S〆 2a-196
s々ch3 2a-197
>P 2a-198
2a-199 H
2a-200 H
經濟部中央標準局員工消費合作社印製
2a-201 H
2a-202 H
2a-203 H h3c^. 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 81 _ v I 鱗 513422 A7 B7 五、發明説明（78 )
2a-204 'Η3 、sAch3 2a-205 、s〜f3 2a-206 ^Η5 2a-207 、广 c〇h7 2a-208
.CH3 、s' 、ch3 2a-209 2a-210 2a-211 經濟部中央標準局員工消費合作社印製 2a-212 2a-213 、S，>、CH3
本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 82 513422 Μ Β7 五、發明説明（79
2a-214 2a-215 2a-216
2a-217 2a-218
2a-219
2a-220
h3co‘ 經濟部中央標準局員工消費合作社印製 2a-221 2a-222 2a-223 \s^CH2OH 、广 CH2OCH3 、sAc〇ch3 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇Χ297公釐） 83 513422 A7 B7 五、發明説明（
、COOH ¥NHCOXrX2-X3
No. X1-X2-X3 2a-224 2a-225 2a-226
(請先閲讀背面之注意事項V 裝-- 声本頁) 2a-227 2a-228 2a-229 OCH3
訂 2a-230 2a-231 線 經濟部中央標準局員工消費合作社印製 2a-232 2a-233
H3CO
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 84 _ O - 513422 A7 B7 五、發明説明（81
No.
XpX2-X3 2a-234
H3CO
2a-235 2a-236
(請先閱讀背面之注意事項再本頁) •裝· 2a-237 2a-238
、1T 2a-239 2a-240 2a-241
OCH3 線 經濟部中央標準局員工消費合作社印製 2a-242 2a-243
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 85 513422 A7 B7 五、發明説明（82)
No. 2a-244 2a-245 2a-246
XrXrX3
(請先閲讀背面之注意事項再本頁) •裝· 2a-247 2a-248 2a-249
訂 線 2a-250 經濟部中央標準局員工消費合作社印製 2a-251 hoh2c
本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 86 513422 A7 B7 五、發明説明（83 )
、COOH vNHCOXrX2-X3
No.
XrXrX3 2a-252 2a-253 ~0~CH3-Q^ch3 2a-254 s 一 h3c ch3 -p 2a-255 2a-256 H3co
經濟部中央標準局員工消費合作社印製 2a-257
COOH 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 513422 A7 B7 五、發明説明（84
No. X!-X2_X3 2a-258
H3CO
2a-259 2a-260 2a-261
(請先閲讀背面之注意事項再本頁) •裝· 訂 2a-262
// W/^〇CH3 、S 2a-263
OCH3 CH3 2a-264 經濟部中央標準局員工消費合作社印製 2a-265 2a-266 2a-267
CH3 、CH3 CH3 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 88 513422 A7 B7 五、發明説明（85
、COOH *NHCOXrX2-X3
No.
XrX2-X3 2a-268
2a-269 (請先閲讀背面之注意事項再驾馬本頁)
2a-270 2a-271 2a-272
訂 2a-273
2a-274
o 經濟部中央標準局員工消費合作社印製 2a-275 2a-276 2a-277
HON
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 89 513422 A7 B7 五、發明説明（86 )
No. X1-X2-X3 2a-278 2a-279
(請先閱讀背面之注意事項再本頁) 2a-280 2a-281 2a-282 COCH3
、1T 2a-283 2a-284
經濟部中央標隼局員工消費合作社印製 2a-285 2a-286 2a-287
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 90 513422 A7 B7 五、發明説明（87 )
COOH •NHCOXrX2-X3
No.
XrXrX3 2a-288
N 2a-289
COCH3 (請先閱讀背面之注意事項再本頁) ^衣_ 太 2a-290 2a-291 ch3 訂 2a-292 C2H5 2a-293 COCH3 2a-294 經濟部中夬標隼局員X消費合作社中製 2a-295 2a-296 o /0CH3一C^0CH3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 91 513422 A7 B7 五、發明説明（88
XpX2-X3 2a-297 2a-298 2a-299 h3c〇 〇ch3 -c-nH0K〇ch3 och3 (請先閲讀背面之注意事項再本頁) 2a-300 CH3 I ch3 訂 2a-301 h3c 2a-302 2a-303 經濟部中央標隼局員工消費合作社印製 2a-304 2a-305 2a-306 〇ch3 〇ch3 〇ch3hQ^n-chQ^〇h 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 92 513422 A7 B7 五、發明説明（89 )
No. X1-X2-X3 2a.307 h3co 〇c OCH3 OCH3 OCH3 ,ch3 2a-308 2a-309 2a-310
och3 och3 0CH3 (請先閱讀背面之注意事項再5|^本頁) 裝_
、1T 2a-311 h3c 2a-312 2a-313 ~〇-n-c-nH〇^〇h -〇-K-c-nH^〇ch3 *k· 經濟部中央標準局員工消費合作社印製 ch3 2a-314 2a-315
H3CO ch3 OCH3 〇 r=( 〇CH3 OCH3 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 93 513422 A7 B7 五、發明説明（9〇 表2b 表2c 表2d COORi "N-COXrX2-X3 CH^
No. xrx2-x3 2b-l 2b-2 -o (請先閲讀背面之注意事項再
^^N-COX! ·Χ2·Χ3 No. Ri xrx2-x3 2c-l H -o 2c-2 H -o 2c-3 H ~hO^°'hO
COOR, ▼NHCOXrXrX3
經濟部中央標準局員工消費合作社印製
No. R,
XrX2-X3 2d-l 2d-2 2d-3 表纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） -94 513422 A7 B7 五、發明説明（91 表2e
No. 2e-l 2e-2
H H
XrX2-X3 o 2e-3 (請先閱讀背面之注意事項再本頁) 表2f
No. ΧΓΧ2-Χ3 訂 2f-l 2f-2 2f-3 表2g 經濟部中央標準局員工消費合作社印製
No. r3 r4 xrx2-x3 2g.l H S02CH3 本紙張尺度適用中國國家標準（CNS )八4規格（210X297公釐） 95 513422 A7 B7 五、發明説明（92 表2h
、COOH ¥NHCOXrX2-X3
No. ΧΓΧ2-Χ3 2h-l 2h-2 2h-3 2h-4 2h-5 2h-6 、s’CH3
0 (請先閱讀背面之注意事項再本頁) -裝_ 表2i
.COOH 〇 *NHCOXrX2-X3
No.
XrX2-X3 經濟部中央標準局員工消費合作社印製 2i-l 2i-2 2i-3 2i-4 2i-5 2i-6
S 、广 ch3 /
線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 96 513422 A7 B7 五、發明説明（93 表2j
xrxrx3 2j-l 2j-2 2j-3 2H 2j-5 2j-6
(請先閱讀背面之注意事項再 1裝-- 本頁) 、-ιτ 表2k
xrx2-x3 經濟部中央標準局員工消費合作社印製 12 3 4. 5 k.k.kk-k-2 2 2 2 2
本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 97 513422 A7 B7 五、發明説明（94 ) 表3a
No. Ri XrXrX3 3a· -3-4-5-6 3 3 3 3 3 3 3 3 3a 經濟部中央標準局員工消費合作社印製 3a-9 3a-10 3a-ll 3a-12 3a-13 3a-14 3a-15 3a-16 3a-17 3a-18
CH3 H H CH3 H CH3 H CH3 ch3 H CH3 H
CH3 H H3N*C(CH2〇H)3 Na 1/2 Ca H (請先閲讀背面之注意事項再本頁) -裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 98 513422 A7 B7 五、發明説明（95 )
co〇Ri >S02-XrX2-X3 Η No. Ri xrxrx3 3a-19 3a-20 ch3 H h3c -<P^ch3 h3c 3a-21 3a-22 ch3 H 3a-23 3a-24 ch3 H —ch2〇h 3a-25 H 一(CH2)3〇H3 3a-26 3a-27 ch3 H 一 (ch2)7ch3 3a-28 ch3 丨 (請先閱讀背面之注意事項再^^本頁) •裝.
'1T 經濟部中央標準局員工消費合作社印製 3a-29 3a-30 3a-31 3a-32 3a-33 3a-34 3a-35 CH3 ch3 H Na H Na N〇2
本紙張尺度適用中國國家標準（CNS ) A4規格（210Χ297公釐） 99 513422 A7 B7 五、發明説明（96 ) 表3b
No. Rl XrXrX3 3b-l ch3 3b_2 H 3b-3 H 3b-4 H 表3c 經 濟 部 中 央 標 準 局 員 工 消 合 作 社 印 製
No._Rj_XrX2-X3 3c-l Η 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 100
-1UU 5 242 3 A7 B7 經濟部中央標準局員工消費合作社印製
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 101 513422 A7 B7 五、發明説明（98
No. X1-X2-X3 3d-16 3d-17 3d-18 3d-19 3d-20 3d-21 3d-22 3d-23 3d-24 3d-25 3d-26
ch3 H CH3 H -^^-(ch2)4ch3 一 (ch2)3ch3 -NHCH3
-Br
請 閲讀背 之 注意事 項 經濟部中央標準局員工消費合作社印製
NaKa C2卜 外消旋體 外消旋髏 表3e COOR, •NHS02XrXrX3
No. R, 3e-l 1/2Ca c2h5
Br 外消旋體
XrXrX3 ~0~ch3 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 102 513422 A7 B7 五、發明説明（99 ) 上述化D物之物性值如下所不，另，上逑化合物N〇係指 相對應於表中化合物No.者
No.l a - 4 [a]D= -11.5° (CHC13,c=1.01,23.5t：).
No.l a - 5 [a]D= -10.0° (CHC13,c=1.01,25.0t：).
No.l a - 6 CDC13 300MHz 0.93-1.96(14H,m),2.20-2.26(3H,m),3.03j(lHlm),3.67(3H,s),4.99(lH,d,J=6.6Hz), 5.1〇.5.24(2H,m)>7.37.7.51(3H,m),7.54-7.64(3Hlm),7.76-7.88<2H,m),8-ll(lH>m ). IR(CHC13):3384,3278,3026,2952,2874,1727,1436,1411,1324,1155,1097 /cm. [a】D= ·9.0。（CHC13,c=1.04,22·0t：)·
No·l a - 7 CDC13 300MHz 0.93-2.00(14H,m),2.18(lH,m),2.28(2H,t,J=7.2Hz),3.04(lHrra)t5.15-5.25(2Hfm)f 5.28(lH，d，J=6.9Hz)，7.36-7.50(3H，m)，7.54-7.63(3H，m)，7.76-7.89(2H,m), 8.12(lH，m). 經濟部中央標準局員工消費合作社印製 IR(CHC13):3268,3028,2952,2872，1708,1452，1410，1324，1155，1097 /cm· [a!D=-9.1。（CHCac^l.Ol.M.Ot^-
No· 1 a — 8 CDC13 300MHz 0.94-L99(UH,m),2.2i-2.29(3H,m),3.05(lH,m)I3.G7(3H,s),4.92(lH,dtJ=G.3Hz), 5.14-5.30(2H,m),7.70*7.78(6H,m),7.96-8.01(2H,m). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐] '" 一 103 - 513422 A7 B7 五、發明説明（1〇〇) IR<CHC13):3376,3272,3018,2946,2868,1727,1616,1435,1388,1324,1162,1130,1 069 /cm.
[a]D=+1.60 (CHC13，c=1.01,24.0t：)· mp.ll7-119t：.
No.l a - 9 CDC13 300MHz 0.95-2.08(14H，m),2.19(lH，m), 2.32(2H,t,J=7.2Hz)，3.06(lH,m),5.20-5.30(2H，m ),5.34(lH,d,J=6.6Hz),7.69-7.78(6H,m),7.96.8.03<2H,m). IR(CHC13):3260,3020,2950,2868,1708,1389,1324,1162,1130,1069 /cm.
[a]D= +13.3。（CHC13，c=1.05,24.0t：)· mp.llS-120t：
No.l a - 1 0 ' CDC13 300MHz 0.96-1.98(14H,m),2.15.2.32(3H,m),3.04(lH,m),3.66(3H,s),5.12. 5.26(5Hfm),7.67-7.78(4H,m),7.93-8.07(4H,m). IR(CHC13):3276,30IS,2946,2868,1726,1595,1435,1341,1162,1095 /cm.
[a]D= ·1.5° (CHC13,c=l.01,25.0t：). mp.l33-139X：.
No.l a - 1 1 CD30D 300MHz 經濟部中央標準局員工消費合作社印製 1.05-1.98(14H,m)(2.13-2.22(3H,m),2.97(lH,m),5.09.5.22(2H,m),7.85- 7.92(4H,m),7.95-8.05(4H,m). IR(KBr):3385,3261,3069,3003,2954,2872,1708,1596,1428,14 13,1378,1343,132 6,1236,1186,1160,1096 /cm. mp. 144 -146^1.
No.l a - 1 2 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 104 513422 A7 B7 五、發明説明（101 經濟部中央標準局員工消費合作社印製 CDC13 300MHz0.96-1.96(14H，m)，2.22-2.27(3H，m)，3.03(lH,m)，3.66(3H，s)，3.87(3H，s)，4.86(lH,d,J=6.9Hz),5.18-5.24(2H,m),6.99-7.02(2H,m),7.55-7.66(2H,m),7.66.7.69<2H,in)f 7.89-7.92(2H,m). IR(CHC13):3374>3270,3016,2948,2870#1726,1608,1518,1487,145S, 1437,1248,1 157,1037. [a]D=+4.2° ((311013,0=1.01,24=). mp.85.87t：. No.l a — 1 3 CDC13 300iMHz 0.97-1.99(14H,m),2.18(lH,m),2.30(2H,t,J=7.2Hz),3.04(lH,m),3.86(3H,s),5.18( lH,d,J=5.7Hz),5.23-5.26(2H,m),6.99-V.02(2H,m),7.55-7.58(2H,m),7.66-7.6S(2 H,m),7.89-7.92(2H,m). IR(CHC13):3380,3260>3020>2948,2868,1708,1608,1519,14S7,145S,1306,1293>1 248,1156 /cm. [a]D=+18.3〇 (CHC13，c=1.00,25.5r). No.l a - 1 4 CDC13 300MHz 0.98-2.00(14H，m)，2.20(lH,m)，2.25(2H，t，J=7.2Hz)，3.02(lH，m)，3.67(3H，s)，4.85( lH，d，J=6.3Hz)，5.19-5.25(2H，m)，7.13(lH，dd,J=4.8,3.6Hz)，7.39(lH，d，J=4.8Hz)， 7.40(lH,d,J=3.6Hz),7.71.7.74{2H,m),7.86-7.89(2H,m). IR(CHC13):3374,3270,3018,2946,2868,1727,1593,1434,1322/cm. [cr]D=+5.6° (CHC13，c=l.01,24=). mp.69-7lt：. '* j No.l a - 1 5 CDC13 300MHz (請先閱讀背面之注意事項再HI本頁) -裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 105 513422 A7 B7 五、發明説明（102 經濟部中央標準局員工消費合作社印製 0.95-2.00(14H，m),2.17(lH，m)，2.32(2H，t,J=7.2Hz)，3.03(lH,m)，5.20(lH，d,J=6.9 Hz),5.24-5.2S(2H,m),7.13(lH,dd,J=4.8,3.3Hz),7.38(lH,d,J=4.8Hz),7.43(lH,d,J =3.3Hz),7.73(2H,d,J=8.4Hz),7.87(2H,d,J=8.4Hz). IR(CHC13):3260,3022,2948,2868,1709,1593,1404,1321,1154/cm. [a]D=+20.8° (CHC13,c=1.07,23t：).mp.71-73^3. No.l a — 1 6 CDC13 300MHz 0.98.2.00<14H,m)>2.27(2H,t>J=7.5Hz),2.28(lH,m),3.13(lH,m),3.66(3H,s),4.90( lH，d，J=6.9Hz)，5.25-5.29(2H,m)，7.40-7.65(6H，m)，7.76(lH,d,J=S.4Hz),7.90-8.02 IR(CHC13):3376,3276,3018,2946,2868,1726,1593,1435,1394,1322,1159/cm. [a]D= +7.0° (CHC13，c=1.07,24t：). No.l a - 1 7 CDC13 300MHz 1.02-2.07(14H，m)，2.25(lH,m)，2.34(2H，t，J=6.6Hz),3.14(lH，m),5.2S-5.33(3H，m)， 7.39-7.57(4H,m),7.62.7.65(2H,m),7.76(lH,d,J=8.1Hz),7.89.8.02(4H,m). IR(CHC13):3260,2948,2868，1709，1593，1394，1324，1157/cm. [a]D=+20.2〇 (CHC13,c=1.02,24t：). No.l a — 1 8 CDC13 300MHz 1.05-1.97(14H,m)，2.25(2H，t，J=7.2Hz),2.33(lH,m),3.12(lH,m)，3.67(3H.s)，4.91( lH,d,J=6.6Hz),5.24-5.29(2H,m),7.24(lHtdfJ=3.9Hz),*7.39-7.45(3H,m),7.56(lH, d,J = 3.9Hz),7.59-7.62(2H,m). IR(CHC13):3372,3272,,30 18,2946,2868,1727,1433,133 1,1 152/cm. [alD=-5.7〇(CHC13,c=1.01，23X：). (請先閱讀背面之注意事項再本頁) -裝·
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 106 513422 A7 B7 五、發明説明（103
No.l a - 1 9 CDC13 300MHz 1.05- 2.05(14H,m),2.28-2.33(3H,m),3.13(lHfm),5.18(lH,d,J=6.3Hz),5.27-5.31(2 H,m),7.24(lH,d,J=4.2Hz)l7.39.7.42(3H,m),7.56(lH,d,J=4.2Hz),7.5S-7.62(2H,m ). m(CHC13):3372l3254,3018,2948,2868,n〇7,1431,1328,1151/cm. [a]D=+4.5〇 (CHC13，c=1.01，21.5t：). No.l a - 2 0 CDC13 300MHz 1.05- 2.00(14H，m)，2.26(2H，t，J=7.5Hz)，2.33(lH，m)，3.11(lH，m)，3.68(3H,s)，4.92( lH，d，J=6.0Hz)，5.27(2H，m)，7.05(lH，m)’，7.10(lH,d，J=3.6Hz)，7.25(lH，m),7.32(l H, m),7.49(lH,d,J=3.6Hz). IR(CHC13):3372,3272,3018,2946,2686,1727,1438,1417,1333,1151/cm. [a]D=-9.2〇 (CHC13,c=1.01,25t：). No.l a - 2 1 CDC13 300MHz I. 02-2.01(14H，m)，2.28-2.34(3H,m)，3.13(lH，m),5.12(lH，d，J=6.9Hz)，5.28-5.32(2 H，m)，7.06(lH，m)，7.10(lH,d，J=3.9Hz)，7.25(lH，m)，7.32(lH，m)，7.50(lH，d，J=3.9 Hz). IR<CHC13):3350,3250,2948,1709,1440,1420,1330,1151. [ctjD=十2·5〇 (011(:13/=1.00,251). (請先閱讀背面之注意事項再Jll本頁) 裝· 訂 -線 經濟部中央標準局員工消費合作社印製
No.l a — 2 2 CDC13 300MHz 0.96-2.05( 14H, m), 2.25( lH，m),2.35(2H,t,J=7.0Hz),3.11(1 H，m)，5.20-5.34(2H,m)， 5.41(lH,d,J=6.6Hz),7.31-7.49(5H,m),7.62(iH,d,J=7.8Hz),8.11(lH,d.d,J=1.8an 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 107 513422 A7 B7 五 、發明説明（仙 經濟部中央標準局員工消費合作社印製 d7.8Hz),8.35(lH，d，J=1.8Hz). IR(CHC13):3384,3271，3025,2958，1708，16O8,1559，1537，1357,1168/cm. [a]D=+l8.3(CHC13,C=0.31,22t：). No.l a — 2 3 CDC13 300MHz 0.97.2.07(14H,m),2.24(lH；in),2.35(2Hft,J=6.9Hz),3.09(lH,m),3.86(3Hfs),5.24. 5.35(2H,m),5.44(lH,d,J=6.3Hz),6.97.7.00(2H,m),7.26-7.28(2H,m),7.59(lH,d,J =8.lHz),8.06(lH,d.d,J=2.1and8.lHz),8.29(lH,d,J=2.lHz). IR(CHC13):3384,3270,2959,1709,1609,1535,1519,1357,1302,1255,1226,1169/c m. [a]D=+l7.0* (CHC13rC=1.00,2lt：). No.lNo.l a - 2 4 CDC13 300MHz 0.95.2.00(14H,m),2.20-2.25(lH,m),2.26(2H,t,J=T.2Hz),3.02-3.10(lH,m), 3.66(3H,s),4.92(lH)d,J=6.6Hz),5.16-5.31(2Hfm),7.52-7.60(3H,m),7.94- 8.06(6H,m). IR(CHC13):3376,3020,2946,2868，1726，1436，1366，1298，1164，1090，S90/cm. [a]D==+11.2±0.5· (CHC13,c=1.04,23.5t：.) mp. 101- 103*C No.l a — 2 5 CDC13 300MHz 0,95-2.08(14H，m)，2.15-2.22(lH，m)，2.33(2H，t,J=6.9Hz)，3.02.3.10(lH，m)，5.21， 5.31(2HIm)>5.34(lH,d,J=6.3Hz),7.51.7.59(3Htm),7.92.8.07(6H,m). IR(CHC13):3258,3022,2948,2868,1707,1399,1328,1298,1163,1089,105 1,892/cm [a ]D==+29.8 士 0.7· (CHCl3，c=1.05,25X)) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 108 (請先閱讀背面之注意事項再m*本頁) 裝. 訂 線_ 513422 A7 B7 五、發明説明（1Q5 mp.l58-160t：
No.l a ~ 2 6
Anal. Calcd for C26H30N304SNa 0.8H2O:C,60.29;H,6.15;N,8.11;S,6.19;Na, 4.44.
Found:C，60.15;H，6.19;N,8.15;S，6.03;Na,4.98· [a]B= -16.6° (CHC13,c=1.04,25.0t：).
No.l a ~ 2 7 CDC13 300MHz 0.92-1.98(14H,m),2.20(lH,m),2.26(2H,t,J=7.5Hz),3.03(lH,m),3.12(6H,s),3.66( 3H,s),4.87(lH,d,J=6.6Hz),5.16-5.32(2H,m),6.73-6.80(2H,in),?.88-8.00(6H,m). IR(CHC13):3376,3020,2946,1726,1601,1518,1442,1419,1362,1312,1163,1133,1 088 /cm.
[a]D==+55.3。（CHC13,c=0.53,24.0t：)· mp.158.168X：
No.l a — 2 8 CDC13+CD30D 300MHz 0.99-2.14(14H,m),2.21(lH,m),2.31(2H,t,J=7.2Hz),2.94(lH,m),3.12(6H,s),5.22- 5.38(2H,m)f6.73.6.81(2H,m),7.87-8.00(6H,m). 經濟部中央標準局員工消費合作社印製 IR(KBr):3434,3309,2946,1708,1604,1520,1442,1416,1366,1312,1252,1164,115 5,1134,1091 /cm.
[ajD=無法测定（著色，能量不足） mp.193.196t：
No.l a — 2 9 CD30D 300MHz 1.02-1.96(l4H,m),2.10(2H,t,J=7.8Hz),2.16(lH,m),2.98(lH,m),3.1L(6H,s),5.07- 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）, 109 513422 A7 B7五、發明説明（106 ) 經濟部中央標準局員工消費合作社印製 5.27(2H,m),6.80-6.87(2H,m)>7.84.8.00(6H,m). IR(KBr):3433,3087,3004,2949,2871,1604,1565,1520,1444,1420,1364,1312,125 3,11638,1136,1090 /cm. [or]D=無法測定 No.l a — 3 0 CDC13 300MHz 0.95-1.99(14H,m)，2.22(lH,m)，2.26(2H,t,J=7.2Hz),2.35(3H,s),3.06(lH，m),3.66( 3H,s),4.95(lH,dfJ=6.9Hz),5.15-5.30(2H,m),7.26-7.32(2H,m),7.97-8.06(6H,m). IR(CHC13):3374,2996,2946,2868,1763,1728,1591,1495,1435,1368,1299,1228,1 192,1163,1139 /cm. [a]D==+12.9° (CHC13，c=1.04,26.0t：)· No.l a ~ 3 1 CDC13 300MHz 0.93-2.01(14H,m),2.19(lH,m),2.31(2H,t,J=7.2Hz),2.35(3H>s),3.06(lH,m),5.17- 5.32(2H,m)，7.25-7.32(2H,m)，7.96-8.07(6H,m). IR(CHC13):3267,3028,2952f2874,1759,1708,1592,1495,1368,1328,1299,1163,1 138,1088,1050,1008/cm. [a]D=+21.7* (CHC13,C=0.51,22t：). No.l a — 3 2 CDC13 300MHz 0.93· 1·99(14Η, m)，2.2 l(lH，m)，2.27(2H，t，J=7.2Hz)，3.05(lH，m), 3.67(3H，s), 4.92( lH,d,J=6.6Hz),5.15-5.30(2H,m),6.72(lH,s)f6.96-7.00(2HIm)>7.86.8.04(6H>m). IR(CHC13):3374,3276>3〇 18,2946,2686,1725,1605,1589,1502,1433,1396,1330,1 j 271,1164,1135,1089 /cm· [a]D= +18.6° (CHC13,c=1.00,26.0t：). j No.l a - 3 3 丨 (請先閱讀背面之注意事項再—本頁) •装·
、1T 線 本纸浪尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） - 110 513422 經濟部中央標準局員工消費合作社印製 A7B7__ 五、發明説明（107 ) CDC13+CD30D 300MHz 0.98-2.08(14H,m),2.20(lH,m),2.28(2H,t,J=7.2Hz),2.98(lH,m),5.18-5.32(2H,m), 6.92-6.99(2H,m),7.85-8.02(6H,m). IR(KBr):3385,3248,2948,2876,1717,1601，1505,1430,1399,1296,1280,1219,116 5,1136,1092 /cm. [a]D= ·16·0° ((：Η3ΟΗ^=1·08,26·0Χ：)·. mp.208-210t： No.l a - 3 4 mp.82.83t： { a ]D=+10.6。（CHC13,c=1.01，23.5t：). No.l a — 3 5 : mp.80-82t： [a】D= ·1.8〇 (¢11013^=1.07,22.(^). No.l a — 3 6 TLC Rf=0.25 (醋酸乙酯 _n_ 己烷=1 : 1(〇.3%醋酸）） No.l a - 3 7 CDC13 300MHz 0.92-1.96(14H，m),2.21(lH，m),2.27(2H,t，J=7.4Hz)，3.01(lH,m)，3.66(3H，s),4.71( lHtd,J=6.6Hz),5.14.5.29(2H,m),7.12(lH>dlJ=16.2Hz),7.24(lH,dlJ=16.2Hz),7.2 8-7.42(3H,m),7.52.7.56(2Hfra),7.62(2H,dlJ=8.7Hz)f7.85(2H,d,J=8.7Hz). IR(CHC13):3384,3283,3023,2954,2876,1730,1595,1494,1317,1163,1147 /cm. [a】D=+10.5。（CHC13，c=1.01，24t：). mp 116-117 °C. No.l a - 3 8 CDC13 300MHz 0.92-1.99(I4H,m),2.17(lHtm),2.32(2H,t,J=7.2Hz),3.02(lH,m),5.23-5.29(3H,m), (請先閱讀背面之注意事項再本頁 裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 111 513422 A7 _____ B7五、發明説明（1〇8 ) 經濟部中央標準局員工消費合作社印製 7.11(lH,d,J=16.2Hz),7.23(lH,d,J=16.2Hz),7.28-7.41(3H,m),7.52-7.55(2Hfin),7. 61(2H,d,J=8.7Hz),7.86(2H,d,J=8.7Hz)? IR(CHC13):3515,3384,3270,3022,3015,2957,2876,2669,1708,1595,1496,1320,1 157 /cm. [o:】D=+27.r (011013/=1.02,241). No.l a — 3 9 CDC13 300MHz 0.92-1.99(14H,m),2.15(lH,m),2.28(2H,t,J=7.4Hz),3.01(lH,m),3.68(3H,s),4.96( lH,d,J=6.6Hz),5.16-5.32(2H,m),6.60(lH,d,J=12.0Hz),6.74(lH,d,J=12.0Hz),7.1 6-7.23(5H,m),7.35(2H,d,J=8.4Hz),7.72(2H,d,J=8.4Hz). IR(CHC13):3384,3283,3023,3015,2954,2876,1730,1595,1493,1324,1163,1147 /cm. [a]D=+13.7e (CHC13，c=1.00,24t：)· No.l a - 4 0 CDC13 300MHz 0.90-2.16(14H，m),2.12(lH,m),2.34(2H，t，J=7.2Hz)，3.02(lH，m)，5.16(lH,d，J=6.9 Hz)，5.23-5.34(2H,m),6.60(lH,d，J=12.3Hz),6.74(lH,d，J=12.3Hz),7.14-7.24(5H, m),7.35(2H,d,J=8.lHz),7.72(2H,d,J=8.lHz). IR(CHC13):3515,3384,3269,3025,3021,3014,2957,2876,2668,1709,1595,1322,1 162,1147 /cm. [a】D=+26.4e (CHC13,c=1.00,24t：)· No.l a — 4 1 CDC13 300MHz | I 0.98-1.99(14H,m)f2.17(lH,m),2.32(2H,t,J=7.2Hz),3.00(lHtm),3.84(3Hfs),5.20. :1 5.26(3H,m),6.90-6.95(2H,m),6.98(lH>d,J=16.2Hz)>7.17(lH,dfJ=16.2Hz)f7.46- 7.49(2H,m),7.58(2H,d,J=8.4Hz),7.83(2H,d,J=8.4Hz). (請先閱讀背面之Ϊ事項再nf. 本頁)
、-IT 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 112 513422 A7 B7 五、發明説明（109) 經濟部中央標準局員工消費合作社印製 IR(CHC13):3258,3018,3002,2950,1709,1590,1509,1457,1404,1302,1250,1153 /cm. [or】D=+30.2e (ΟΗα3,ο=1·00,23Χ：). mp.99-100 No.l a — 4 2 CDC13 300MHz 1.0M.99(14H,m),2.28(2H,t>J=7.2Hz),2.30(lHlm),3.10(lH,m),3.66(3H,s),5.07( 1H,br),5.25-5.30(2H,m),6.98-7.04(2H,m),7.16(lH,d,J=16.2Hz)>7.28-7.37(3H,m), 7.47-7.50(3H,m). IR(CHC13):3372,3276,3020,2946,2870,1727,1491,1433,1331,1152 /cm. [<x]D= ·11·5。（ΟΗΟαο^Ι.ΟΤβΙ.δΧ^- Νο.Ι a — 4 3 CDC13 300MHz 0.98-2.00(14H,m),2.11-2.36(3H,m),3.12(lH,m)l5.10(lH,d,J=6.6Hz),5.29-5.32(2H,m),6.99-7.04(2H,m),7.23(lH,d,J=21.6Hz),7.32.7.49(6H,m). IR(CHC13):3380,3248,3020,2948,2868,1709,1491,1430,1329,1151/cm. [a]D=+3.40 (CHC13,c=1.03,25t：>· No.l a - 4 4 CDC13 300MHz 1.00-2.00(14H，m)，2.13(lH，m)，2.29(2H，t，J=7.4Hz)，2.90-3.13(5H,m)，3.68(3H，s), 4.74(lH，d，J=6.6Hz)，5.15-5.30(2H，m),7.18-7.29(7H，m)，7.76(2H,d,J=8.1Hz). IR(CHC13):3384,3282,3063,3028,3023,3016,2953,2876,1730,1599,1496,1319,1 157 /cm. I [a]D=+2.3〇 (CHC13,c=1.00>25t：). mp.85.0-86.0^ 本纸張又度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再頁) -裝.
、1T 線 113 513422 A7 B7 五、發明説明（110 經濟部中央標準局員工消費合作社印製
No.l a — 4 5 CDC13 300MHz 0.90-2.05(14H,m)，2.09(lH,m)，2.35(2H，t,J=6.9Hz)，2.90-3.13<5H，m),5.18(lH，d，J =6.6Hz)，5.24-5.34(2H,m),7.10-7.27(7H，m),7.76(2H，d，J=8.4Hz). IR(CHC13):3510,3384,3270,3087,3063,3026,3018,3014,2955,2876,2670, Π〇8,1 599,1496,1318,1157/cm. [a]D=+8.5〇 <CHC13,c=1.01,25t：)e No.l a - 4 6 [a】D=+6.S° (CHC13,c=1.05,25t：)· mp.99-100t：. No.l a — 4 7 .. CDC13 300MHz 0.97.2.01(14H,m)，2.14(lH，m),2.36(2H，t,J=7.2Hz)，3.02(lH，m)，5.23(lH，d，J=5.4 Hz),5.26-5.30(2H,m),7.37-7.39(3H>m),7.54.7.58(2H,m),7.63-7.66(2H,m),7.85-7. 88(2H,m). IR(CHC13):3375,3260,3022,2948,2212,1707,1596,1497,1396,1322,1160/cm. [〇f]D=+25.0° (CHC13，c=1.02,24t：). mp.ll7-118t：. No.l a - 4 8 CD30D 300MHz 1.05-1.93(14H,m),2.10.2.15(3H,m)(2.96(lH,m),5.08-5.28(2HIm),7.38-7.40(3H> m)，7.554-7.56(2H，m),7.69(lH，d，J=8.4Hz)，7.87(lH,d，J=8.4Hz)· No.l a - 4 9 CDC13 300MHz 0.96-l,97(14H,m),2.24(lH，m)，2.31(2H，t,J=6.9Hz)，3.05(lH,m)，3.69(3H，s),5.15( lH,d,J=6.6Hz),5.25-5.27(2H,m),7.4〇.7.43(3H,m)f7.61-7.64(2H,m),7.85(lH,d,J =8.lHz),8.07(lH,dd,J=8.1,1.8Hz),8.58(lH,d,J=1.8Hz). (請先閱讀背面之注意事項再本頁)
、1T 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 114 513422 A7 B7 五、發明説明（111 ) IR(CHC13):3374,3020,2948,2870,2212,1726,1606,1530,1493,1437,1345,1167/c m.
[cr]D=+2.4° (CHC13,c=1.03,25t：)· mp.77-79^C.
No.l a — 5 0 CDC13 300MHz 1.00.2.02(14H,m),2.20(lH,m),2.34(2H,t,J=6.6Hz),3.08(lH,m),5.26-5.29(2H,m), 5.41(lH,d,J=6.9Hz),7.40-7.43(3H,m),7.61-7.64(2H,m),7.84(lH,d,J=8.lHz),8.07 (lH,dd,J=8.4,1.8Hz),8.57(lH,dd，J=1.8Hz). IR(CHC13):3380,3254,2952,2880,2212,1707,1606,1531,1493,1409,1344,1166. [a]D=+23.4〇 (CHC13,c=1.00,25t：).
No.l a — 5 1 CDC13 300MHz 0.95-1.98(14H,m)，2.23(lH,m),2.30(2H,t,J=7.2Hz),3.00(lH,m),3.66(3H,s),4.56( 2H,br),4.70(lH,d,J=6.9Hz),5.20.5.29(2H,m),7.15(lH,dd,J=7.8,1.8Hz),7.23(lH, d,J=1.8Hz),7.36-7.39(3H,m),7.46(lH，d，J=7.8Hz),7.53-7.56(2H，m)· IR(CHC13):3494,3386,3028,2952,2874,1725,1611,1559,1497,1422,1317,1162/c
No.l a ~ 5 2 CDC13 300MHz 0.96-2.04(16H,m),2.20(lH,m),2.36(2HftfJ=6.9Hz),2.99(lH,m)>5.17(lH,d,J=6.3 經濟部中央襟準局員工消費合作社印製
Hz)，5.28-5.31(2H,m),7.18(lH,dd，J=9.6,1.8Hz),7.25(lH,m)，7.36-7.39(3H，m),7.4 6(lH,d,J=7.8Hz)，7.52-7.56(2H，m)· IR(CHC13):3482,3378,3260,3022,2948,2868,1708,161 2,1495,1422,1317/cm.
[a]D=-fl5.0° (CHC13,c=1.00,24t：). 本紙張尺度適用中國國家標準（CNS ) A4規格（2丨〇'乂297公釐） 115 513422 A7 B7 五、發明説明（112 )
No.l a — 5 3 CDC13 300MHz 1.01.2.05(15H,m)l2.31(2H,t,J=7.2Hz),3.10(lH,m),3.67(3H,s),5.02(lH,br),5.26-5.33(2H,m),7.18(lH,d，J=4.2Hz),7.36-7.39(3H,m),7.48(lH,d,J=4.2Hz),7.51-7.5-5 (2H，m)· IR(CHC13):3372,3270,3018,3004,2946,2868,2202,1726,1486,1433,1336,1154/ cm.
[a]D=+〇.6° (ΟΗ013,ο=1.11,25ΐ：), [a]436 +17.8° (CHC13,c=l.ll,25iC).
No.l a — 5 4 CDC13 300MHz 0.99-2.11(14H,m)l2.27(lH,m),2.37(2H,t,J=7.5Hz),3.13(lH,m),5.16(lH,d>J=6.6
Hz),5.31-5.35(2H>m)f7.18(lH,d,J=3.6Hz),7.37.7.39(3H,m),7.50(lH,d,J=3.6Hz), 7.52-7.55(2H,m). IR(CHC13):3484,3370,3246,2948,2868,2202,1708,1486,1429,1335,1153/cm. [a]D=+17.8〇 (ΟΗ013,〇=1.00,24Χ：). mp.95-96t：
No.l a — 5 5 CDC13 300MHz 0.95-1.92(14H,m),2.15(lH,m),2.24(2H,t,J=7.5Hz),3.00(lH,m),3.66(3H,s),5.10-5.30(3H,m)>7.40-7.60(7H>m),7.70(lH,dlJ=7.8Hz),8.08(lH,d,J=8.lHz). IR(CH C13):3356,3020,2948,2868,2210,1727,1490,1458,1437,1341,1165/cm.
[a 】D=-58.4e ((^013,(:=1.00,261). mp.84-85t：.
No.l a — 5 6 CDC13 300MHz 0.95-L95(14Hfm),2.10(lH,m),2.27(2H,t,J=6：9Hz),3.00(lH,m),5.17-5.21(2H,m), 5.38(m，d，J=6.9Hz)，7.39-7.60(7H，m)，7.70(lH，dd，J=7.8，1.5Hz)，8.07(lH，J=6.6，l. 5Hz). 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） (請先閱讀背面之注意事項再
經濟部中央標準局員工消費合作社印製 116 513422 A7 B7 五、發明説明（113) 經濟部中央標準局員工消費合作社印製 IR(CHC13):3364,3026,2952,2874,2212,1707,1597,1491,1458,1411,1341,1164/cm. [a]D=-43.1° (CHC13,c=1.00,25t：). No.l a — 5 7 CDC13 300MHz 0.99.1.97(14H,m),2.23.2.30(3H,m),3.01(lH,m),3.67(3H,s),5.17-5.26(3H,m),7.3 6.7.38(3H,m),7.50-7.56(3H,m),7.60(lH,m),7.83(lH,m),8.05<lH,m). IR{CHC13):3376,3020,2946,2870,1727,1598,1491,1437,1412,1330,1245,1163/ cm. [a】D=-12.7e (CHC13,c=1.00,24t：). No.l a — 5 8 CDC13 300MHz 0.97-1.98(14H，m),2.20(lH，m)，2.33(2H，t，J=6.9Hz)，3.02(lH,m),5.19-5.28(3H,m)， 7.36-7.38(3H，m)，7.47-7.55(3H，m)，7.69(lH,m)，7.83(lH，m)，8.04(lH，m)· IR(CHC13):3376,3260,3022,3002,2948,2868,2220,1708,1598,1490,1455,1412,1 327,1162/cm. [〇f]D=-8.6。（CHC13，c=1.01，24t：)· No.l a — 5 9 CDC13 300MHz 0.95· 1.99(24H，m)，2.20(lH,m)，2.28(2H，t，J=7.8Hz)，2.53(lH，s)，2.S)6(lH，m)，3.69( 3H，s)，4.99(lH,d,J=6.6Hz),5.18-5.20(2H,m)，7.53(2H，d，J=8.4Hz)，7.82(2H,d，J=8. j 4Hz). I I IR(CHCI3):3583,3376,3002,2936,2852,1725,159 1,1490, H37.1393,1325,1160/ cm. [arjD=-8.8e (CHa3，c=1.00,24T：). (請先閲讀背面之注意事項再本頁) 裝·
、1T 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 117 513422 經濟部中央標準局員工消費合作社印製 A7 B7_ _五、發明説明（114 ) No.l a — 6 0 i CDC13 300MHz 0.96-2.05(24H,m),2.22(lH,m),2.33(2H,m),2.88(lH,m),5.22-5.26(2H,m),5.30(lH,; d,J=5.7Hz),7.50(2Hfd,J=8.7Hz),7.80(2H,d,J=8.7Hz). IR(CHC13):3376,3260,3022,2936,2852,1710,1592,1491,1452,1395,1325,1159/c | j m. [a]D=-8.9〇 (CHC13，c=1.06,24t：), mp.88-91^3 No.l a - 6 1 CDC13 300MHz 0.95-2.24(23H，m)，2.29(2H，m)，2.99(lH,m),3.69(3H,s),4.76(lH，d，J=6.3Hz),5.21· 5.24(2H,m),6..28(lH,m),7.50-7.53(2H,m),7.77.7.80(2H,m). IR(CHC13):3374,3270,3018,2942,2868,2196,1726,1589,1490,1435,1324,1158/0 m. [a]D=+7.7〇 (CHC13,c=1.02,24t：), mp.93-95t： No. 1 a — 6 2 CDC13 300MHz 0.96-2.45(23H，m)，2.36(2H，d，J=6.9Hz)，2.99(lH，m)，5.24(lH，d，J=6.3Hz),5.24-5.3 2(2H,m),6.28(lH,m),7.5〇.7.53(2H,m),7.78-7.81(2H,m). IR(CHC13):3468,3374, 3260,3020,2942,2868,2196,1598,1490,1455,1398,1322,1157/cm. [or]D=+19.4° (CHC13，c=1.03,24t：). No. 1 a — 6 3 CDC13 300MHz 0.93-1.95(25H,m)，2.16(lH，m)，2.29(2H，t,J = 7.2Hz)，2.43(2H,t，J=6.9H2〇,2.94(lH, m)(3.G9(3H,s)I4.95(lH,dtJ=6.9Hz)l5.21.5.24(2H,m),7.49(2H,d,J=8.7Hz),7.79(2 H,J=8.7Hz). (請先閱讀背面之注意事項再本頁) .裝· 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 118 513422 A7 B7 五、發明説明（115 IR(CHC13):3376,3018,2946,2866,2222,1727,1592,1456,1435,1325,1158/cm. [a]D=+3.79 (CHC13,c=1.00,25t：). No.l a - 6 4 CDC13 300MHz 0.93-1.97(26H,m),2.35(2H,t,J=7.2Hz),2.43(2H,t,J=7.2Hz),3.0O(lH,m),5.08(lH, d,J=6.6Hz),5.26.5.27{2H,m),7.49(2Hld,J=8.7Hz),7.78(2H,d,J=8.7Hz). IR(CHC13):3260,3020,2948,2864,2222,1708,1592,1489,1456,1397,1324,1156/c m. [a 】D=+14.4e (CHC13,c=1.00,25t：) mp.70-7lt： · 請 先 閎ik 背 之 注 意 項 再 m 本 頁 裝 經濟部中央標準局員工消費合作社印製
No.l a - 6 5 CDC13 300MHz 0.95-1.98(14H,m),2.18(lH,m),2.30(2H,t,J=7.2Hz),3.00(lH,m),3.67(3H,s),4.83( lH,d,J=6.9Hz),5.22-5.25(2H,m),5.54(lH,br),6.82-6.85(2H,ra)l7.42.7.45(2H>m), 7.59-7.62(2H,m),7.82-7.85(2H>m). IR(CHC13):3576,3374,3018,2946,2868,2208,1725,1607,1587,1514,1435,1325,1 270,1162,1133/cm. [a]D=+9.1° (CHC13,c=1.03,24t：), mp.lll-112r No.l a — 6 6 CDC13 300MHz 0.97-2.03(14H，m)，2.15(lH,m),2.35(2H，t,J=7.5Hz),3.00(lH，m),5.17(lH，d，J=6.6 Hz),5.26-5.30(2H，m)，6.82-6.85(2H，m)，7.42-7.45(2H,m)，7.59-7.62(2H，m)，7.82-7. 85(2H,m). IR(CHC13):3260,2948,2870,2203,1709，1607，1587,1514,139G. 1325,1270· 1162,1 133/cm. [ajD二·21.0〇 (CHC13，c=1.00,23t：)， mp.161.162t： 訂 ►線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 119 513422 A7 B7 五、發明説明（116 經濟部中央標準局員工消費合作社印製
No.l a — 6 7 CDC13 300MHz 0.95-1.98(14H,m),2.20(lH,m),2.29(2H,t,J=7.2Hz)>3.01(lH,m),3.67(3H,s),4.82( lH,d,J=6.6Hz),5.19-5.27(2H>m),7.05-7.10(2H,m),7.51-7.56(2H,m),7.61-7.64(2 H,m),7.84-7.87(2H,m). IR(CHC13):3374,3280,3020,2946,2868,2214,1727,1589,1509,1435,1327,1233,1 161,1134/cm. [a]D=+6.7° (CHC13，c=1.01,24t：)，mp.84-85t： No.l a - 6 8 CDC13 300MHz 0.96-2.01(14H,m),2.15(lH，m)，2.34(2H，t，J=6.9Hz)，3.02(lH,m)，5.23-5.27(3H，m)， 7.04·7.10(2Η，ιη)，7.51·7·56(2Η，ιη)，7.61·7.64(2Η，ιη)，7.85·7,88(2Η，πι). IR(CHC13):3374,3258,3020,2948,2868,2214,1708,1589,1509,1455,139S, 1322,1 156/cm. [a ]D=+22.6° No.l a - 6 9 CDC13 300MHz 0.95-L98(14H,m),2.19(lH,m)，2.29(2H,t，J=7.2Hz)，2.39(3H，s)，3.01(lH，m)，3.69( 3H，s)，4.80(lH，d，J=6.6Hz)，5.20-5.29(2H，m)，7.18(2H，d，J=8.lHz)，7.44(2H，d，J=8. lHz),7.62(2H,d,J=8.4Hz),7.84(2Htd,J=8.4Hz). IR(CHC13):3374,3022,2946>2868I2210,1727,1589,1511,1436,1323,1161,1133/c m. [a]D=+9.2〇 (CHC13，c=1.02,2‘ir). mp. 116-118*C
No. 1 a - 7 0 CDC13 300MHz 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) -裝· 訂 線 120 513422 A7 B7 五、發明説明（117) 經濟部中央標準局員工消費合作社印製 1.15-2.00(14H，m)，2.13(lH，m)，2.33-2.38(5H，m)，3.04(lH，m)，5.14(lH，d，J=6.6Hz)， 5.25-5.30(2H,m),7.17(2H，d，J=7.8Hz)，7.44(2H,d,J=7.8Hz),7.62(2H,d,J=8.4Hz), 7.85(2H,d,J=8.4Hz). IR(CHC13):3380,3260,3020,2948,2868,2210,1708,1590,1511,1396,1324,1160,1 133/cm. [a]D=+24.6〇 (CHC13,c=1.00,24t：). No.l a - 7 1 CDC13 300MHz 0.95.1.96(14H,m),2.19(lH,m),2.29(2H,t,J=7.2H2),3.00(lH,m),3.20(lH,s),3.65( 3H,s),4.81(lH,d,J=6.6Hz),5.2〇.5.27(2H,m),7.46-7.54(4H,m),7.62.7.65(2Hfm),7. 85-7.88(2H,m). IR(CHC13):3374,3290,3018,3002,2946,2868,2212,2110,1726,1591,1507,1435, 1401,1324,1161/cm. [a]D=+9.6° (CHC13，c=1.01，24t：)，mp.136.138t：, No.l a — 7 2 CDC13 300MHz 0.96-2.01(14H,m),2.14(lH,m),2.35(2H,t,J=7.2Hz),3.05(lH,m)>3.20(lH,s),5.16( | 1H,d, J=7.2Hz), 5.26-5.29(2H,m)，7.45-7.53(4H，m)，7.63(2H，d，J=8.4Hz),7.87(2H, d,J=8.4Hz). IR(CHC13):3462,3374,3290,3024,2948,2868,2212,2 110,1708,1591,1508,1455,1 401,1321,1274,1160,1132/cm. [a 】D=+24.3e (0^1013,0=1.03,241), 11^.96-991 No.l a ~ 7 3 CDC13 300MHz 0.95-1.98(14H,m),2.19(lH,m),2.27.2.32(5H,m),3.01(lHtm),3.67(3Hls),4.80(lH, d,J=6.6Hz),5.2〇.5.27(2H,m),7.12(2H,m),7.56(2H,m),7.63(2H(m),7.84(2Hfm). IR(CHC13):3374,3276,3018,2946,2868,2214, Π62,1730,1589,1506,1435,1368,1 (請先閱讀背面之注-ή思事項再HI本頁) 裝· 訂 -線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 121 513422 A7 B7 五、發明説明（118 經濟部中央標準局員工消費合作社印製 161/cm. [a]D=+7.8° (CHC13,c=1.02,24t：)，mp.102-104*0 No.l a ~ 7 4 CDC13 300MHz 0.95-2.05(14H,m),2.15(lH,m),2.32.2.37(5Hrm),3.02(lH,m),5.14(lH,d,J=6.6Hz), 5.26-5.30(2H,m),7.10-7.13(2H,m),7.54-7.57(2H,m),7.62-7.64(2H,m),7.84-7.87( 2H,m). IR(CHC13):3482,3250,3022,2946,2868,2214,1716,1709,1589,1507,1454,1396,1 368,1322,1195,1161/cm. [a]D=+15.0〇 (CHC13，c=1.00,24t：)，mp.l29-13lt： No.l a — 7 5 CDC13 300MHz 0.95-1.99(14H,m),2.20(lH,m),2.30(2H,t,J=7.2Hz)，3.02(lH，m),3.67(3H，s)，3.94( 3H,s),4.79(lH>d,J=6.6Hz),5.19.5.29(2H,m),7.60-7.63(2H,m),7.65-7.67(2H,m),7. 86-7.89(2H,m),8.04-8.06(2H,m). IR(CHC13)..3378,3018,2946,2380,1720,1604,1435,1307,1276,1161,1106 /cm. [a]D=+7.3° (CHC13,c=1.01，25t：)，mp.132.133t： No.l a - 7 6 CDC13+CD30D 300MHz 1.04-2.05(14H，m)，2.19(lH，m)，2.32(2H，t，J=6.9Hz)，2.93(lH，m)，5.27-5.3U2H，m)， 7.60-7.63(2H，m)，7.65-7.68(2H，m)，7.86-7.89(2H，m)，8.05-8.O7(2H，m). IR(CHC13):3402,3299,2955,2876,2665,2549，1455，1422，1313，1281，U64 /cm. [a]D=-21.1° (CH3OH,c=1.03,23X：)t mp.227-229(dec.)
No.l a - 7 7 CDC13 300MHz 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再Jll本頁) •裝·
、1T 線_ 122 513422 A7 _____B7五、發明説明（119 ) 經濟中央標準局員工消費合作社印製 0.96.1.99(14H,m),2.20(lH,m),2.30(2H,t,J=7.2Hz),3.02(lH,m),3.68(3H,s),4.88( lH,d,J=6.3Hz),5.19-5.29(2H,m),7.67-7.72(4H,m),7.89-7.91(2H,m),8.24-8.27(2 H，m). IR(CHC13):3376,3276,3020,2946,2870,2214,1726,1594,1519,1455,1435,1389, 1344,1161/cm. [a]D=+7.7° (CHC13,c=1.02), mp.87-89t： No.l a — 7 8 CDC13 300MHz 0.98-2.00(14H,m),2.18(lH,m),2.34(2H,t,J=7.2Hz),3.02(lH,m),5.24-5.28(2H,m), 5.32(lH,d>J=5.7Hz),7.67-7.72(4H,m),7.89-7.92(2H,m)>8.23-8.26(2H,m). IR(CHC13):3374,3260,2948,2214,1708,1595,1344,1160/cm. [a]D=+23.3e (CHC13,c=1.00), mp.102-103^： No.l a ~ 7 9 0.93-2.02(14H,m)，2.13(lH，m)，2.36(2H，t,J=7.1Hz)，3.05(lH，m),3.84(3H，s)，5.18( 1H,br),5.27-5.31(2H,m),6.88-6.91(2H,m),7.48-7.50(2H,m),7.60-7.63(2H,m),7.8 3-7.85(2H,m). IR(CHC13):3380,3252,3020,2950,2868,2208,1708,1589,1511,1457,1396,1321,1 286,1160/cm. [a 】D=+26.7。（CHC13,C=l.〇〇). mp.75.77t： No.l a — 8 0 CDC13 300MHz 0.96-L99(14H,m),2.21(lH,m),2.30(2H,t,J=T.8Hz),3.02(lH,m)t3.68(3H,s),4.80( lH，d，J=6.6Hz)，5.19-5.28(2H，m)，7.51-7.77(5H，m)，7.87'7.90(2H，m)，8.13(lH，m). IR(CHC13):3374,3270,3013,2946,2868,2216,1726,1607,1567,1527,1495,1456,1 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項 本百〇 .裝· 、-ιτ 絲 123 ~ 513422 A7 B7 五、發明説明（12〇 ) 436,1344,1296,1161/cm. [a]D=+7.4° (CHC13,c=1.00,22t：), 1^.68-701 No.l a - 8 1 CDC13 300MHz 0.97-2.01(14H,m),2.16(lH,m),2.34(2H,t,J=7.2Hz),3.01(lH,m),5.22.5.28(3H,m), 7.51(lH,m),7.65(lH,m)7.70-7.76(3H,m),7.88.7.91(2H,m),8.12(lH,dd,J=6.9Hz, 1.5Hz). IR(CHC13):3480,3382,3262,3026,2952,2872,2218,1708,1607,1567,1526,1396,1 343,1225,1160/cm. [a]D=+22.0〇 (CHC13,c=1.00), mp.92-94t： No.l a — 8 2 CDC13 300MHz 0.95-1.98(14H,m),2.20(lH,m)>2.29(2H,t,J=7.2Hz),3.01(lH,m),3.67(3H,s),4.30( 2H，br)，4.79(lH,d，J=6.9Hz)，5.20-5.29(2H，m),6.71-6.76(2H，m),7.18(lH，m),7.37( lH,dd,J=7.8,1.2Hz),7.61-7.65(2H,m),7.83-7.87(2H,m). IR(CHC13):3376,3020,2946,2868,2202,1725,1613,1589,1484,1454,1315,1253,1 161/cm. [a]D=+8.9° (ΟΗαΐ3,ο=1.00,22Χ：). mp.ee-TOt： (請先閱讀背面之注意事項再本頁) •裝· 訂 線 經濟部中央標準局員工消費合作社印製
No.l a ~ 8 3 CDC13 300MHz 0.97-1.99(14H,m),2.17(lH,m),2.33(2H,t,J=6.9Hz)f2.99(lH,m),5.20.5.28(2H,m), 5.37(lH>d,J=6.9Hz),6.45(2Hfbr),6.71-6.76(2H,m)f7.19(lHfdd,J=7.8,6.6Hz),7.3 7(lH>m),7.62(2H,dlJ=8.4Hz),7.85(2H,d,J=8.4Hz). IR(CHCU3):3478,3378,3260,3022,2950,2868;2204,1708，1613，1589|1484T1454，1 396,1316,1160/cm. [crjD=+n.r (CHC13，c=1.01)· 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 124 513422 A7 B7 五、發明説明（121) Νο·1 a — 8 4 CDC13 300MHz 1.00-2.08(14H,m)，2.21(lH,m)，2.37(2H,t，J=6.9Hz)，3.06(lH，m),3.86(3H,s),5.29· 5.33(2H,m),5.45(lH,d,J=6.6Hz),6.91-6.94(2H,m),7.56-7.59(2H,m),7.81(lH,d.t, J=8.1Hz),8.04(lH,d.d,J=8.1&1.8Hz),8.57(lH,d,J=2.lHz). IR(CHC13):3492,3254,3028,2954,2202,1708,1597,1512,1344,1291,1250/cm. [a]D=+27.4° (CHC13,C=0.53,23t：).
No.l a — 8 5 CDC13 300MHz 0.96-2.05(14H,m),2.20(lH,m),2.35(2H,t,J=6.9Hz),2.99(lH,m),3.84(3H,s),5.22-5.31(3H,m),6.89(2H,d,J=8.7Hz),7.19(lH，brs),7.29(lH,brs),7.45-7:50(3H，m)· IR(CHC13):3478,3378,3020,2950,2868,2202,1708,1606,1511,1421,1311,1287,丨 1248,1155/cm. [a]D=+17.1e (CHC13，C=1.00,23t：)· No.l a — 8 6 CDC13 300MHz 1.03-2.05(14H,m),2.21(lH,m),2.37(2H,t,J=6.9Hz),3.04(lH,m),5.29.5.33(2H,m), 5.57(lH,d,J=6.3Hz),6.84.6.87(2H,m),7.50-7.53(2H,m),7.79(lH,d,J=8.lHz),8.03 (lH,d,d,J=L5and8.1Hz),8.57(lHfd,J=1.5Hz). IR(CHC13):3250,3024,2950,2868,2200,1707,1515,1344,1271,1166,1143/cm. [cr]D=+21.2° (CHC13,C=0.26,22t：)· (請先閲讀背面之注意事項再本頁) •裝_ 訂 線 經濟部中央標準局員工消費合作社印製
No.l a - 8 7 CD30D 300MHz 1.04-2.00(14Hfm)>2.18(lH,m),2.26(2Hft,J=5.4Hz),2.93(lHfm),5.19-5.24(2H,m)> 6.77-6.80(2H,m),7.05(lH,d.d,J=2.1and8.lHz),7.22(lH,d,J=2.lHz),7.38-7.42(3 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇X 297公釐） 125 513422 A7 B7五、發明説明（122) 經濟部中央標準局員工消費合作社印製 H,m)· IR(CHC13):3377,2952,2873,2204,1705,1607,1515,1425,1312,1267,1222,1153/ cm. [a]D=-15.6° (CH3OH，C=1.02,22t：)· No.l a — 8 8 CDC13 300MHz 0.9〇.1.96(14H,m),2.22-2.31(3H,m),2.95(lHfm),3.65(3H,s),4.87(lH,cl,J=6.6Hz), 5.13.5.28(2H,m),7.46-7.62(3H,m),7.82-7.89(4H,m),7.90.7.96(2H,m),8.42(lH,br s)· IR(CHC13):3376,3016,2946,2868,1720,1677,1592,1514,1498,1429,1376,1314,1 241,1156,1094 /cm. ； [a】D= -10.7。（(:11(:13,0=1.04,22.01) mp.l34-136t： No.l a — 8 9 CDC13+CD30D 300MHz 0.96-2.08(14H,m),2.23(lH,m),2.28(2H,t,J=7.2Hz),2.89(lH,m),5.20-5.32(2H,m), j 7.46-7.62(3H,m),7.82.7.97(6H,m). IR(KBr):3272,3007,2952,2874,1708,1660,1592,1527,1498,1433,1400,1317,126 0,1152,1094 /cm. [a】D= ·24.4。（¢^3011,0=1.02,25.01)0 No.l a ~ 9 0 CDC13 300MHz 0.89-1.96(14H,m),2.23-2.33(3Hlm),2.92(lH>m),3.67(3H,s),4.85(lH>dlJ=6.3Hz), j 5.10.5.25(2H,m),7.81-7.90(4H，m)，8.10-8.18(2H，m)，8.31-8.40(2H，m)，8.77(lH，s)· | IR(CHC13):3372,3018,2946,2868,1718,1685; 1592,1527,1436,1397,1346,1318,1 256,1154,1099 /cm. [a]D= -16.Γ (CHC13,c=l.00.23.Ot：), (請先閱讀背面之注意事項再本頁) 、言 本紙張尺度適用中國國家標準（CNS ) A4規格（2l〇x 297公釐） 513422 一五 .__ 經濟部中央標準局員工消費合作社印製 A7 B7 發明说明（123 Νο·1 a - 9 1 CDC13+CD30D 300MHz 0.94-2.02(14H,m),2.18-2.36(3H，m),2.87(lH,m),5.15·5·30(2Η，πι),7.82-7.92(4H， ! m),8.09-8.16(2H,m),8.30-8.37(2H,m). ! IR(KBr):3284,3112,3006,2952,2874,1707,1593,1528,1498,1399,1348,1320,125 1 9,1153,1093 /cm.
[o:]D= ·26.3° (CH3OH,c=1.01,22t：)·
No.l a - 9 2 CDC13 300MHz 0.93-1.95(14H,m),2.22-2.31(3H,m),2.98(lH,m),3.68(3H,s),5.07(lH,d,J=6.9Hz), 5.10-5.24(2H,m),7.18(lH,m),7.35-7.43(2H,m)f7.70(2H,d,J=7.8Hz),7.88.8.05(4 H, m),8.50(lH,brs). IR(CHC13):3382,3008,2952,1720,1675,1599,1525,1499,1438,1321,1253,1161,1 087 /cm.
[a]D= ·16·6° (ΟΗ(：13/=1·03,24.0Χ：) mp.lOO-lOlC No.l a — 9 3 CDC13+CD30D 300MHz 0.96-2.00(14H,m)，2.18-2.35(3H，m)，2.90(lH，m),5.15-5.30(2H，m)，7.18(lH，m),7.3 3-7.42(2H,m)l7.65-7.74(2Hfm),7.90-8.08(4H,m). IR(KBr):3347,3194,3011,2955,2875,1706,1650,1602,1544,1499,1443,1325,12 65,1165,1091 /cm.
[a】D= -19.4° (CH30H，c=1.00,24.0t：) 1^.158-159=
No.l a — 9 4 CD30D 300MHz ； I. 05-2.00(14H，m)，2.14(lH，m)，2.23(2H，t，J=7.2Hz)，2.98(m，m)，3.80(3H，s)，5.13·; (請先閱讀背面之注意事項再本頁) 裝.
、1T 本紙張尺度適用中國國家標準（CNS ) Μ規格（210X 297公釐） 127 _ 1 07 - 經濟部中央標準局員工消費合作社印製 1 Μ ^___Β7__— 五、發明説明（124 ) 5·27(2Η，ιη)，6·88·6·98(2Η,ιη)，7·54·7·64(2Η，ιη),7·94·8·12(4Η,ιη). \ IR(KBr):3370,3006,2953,1708,1649,1604,1541,1512,1460,1441,1414,1328,130 2,1248,1162,1107,1090,l〇32/cm. [a]D= ·19·1° (CH30H,c=l.01,24=). Νο·1 a — 9 5 CD30D 300MHz 1.04- 2.02(14H,m),2.14(lH,m),2.23(2H,t,J=7.2Hz),2.93-3.02(7H,m),5.13-5.27(2 H,m),6.82-6.92(2H,m),7.51-7.59(2H,m),7.95-8.02(2H,m),8.04-8.11(2H,m). IR(KBr):3370,3006,2953,1708,1649,1604,1541,1512,1460,1441,1414,1328,130 2,1248,1162,1107,1090,1032/cm. [a]D==-17.6e (CH3OH,c=1.01,24t：)· No.l a — 9 6 CD30D 300MHz 1.05- 2.02(14H,m),2.14(lH，m),2.23(2H，t,J=7.2Hz),2.98(lH,m),5.13-5.27(2H,m), 6.75-6.84(2H,m),7.43-7.52(2H,m),7.94-8.12(4H,m). IR(KBr):3339,3197,2953,2875,1707,1644,1606,1541,1514,1446,1325,1293,125 9,1240,1225,1161,1091/cm. [a]D= -18.7° (CH30H,c=1.00,24t：). mp.l93-196t： No.l a - 9 7 d6-DMSO 300MHz 1.05- 2.08(15H，m),2.15(2H，t,J=7.5Hz)，2.89(lH，m)，5.18-5.28(2H,m)，6.78-7.12(3 Hlm),7.73(lH,d.d,J=1.4and7.8Hz),7.91-7.95(3Hfm)f8.14(2H,d,J=8.4Hz)l9.71(l H,s). IR(KBr):3407,3191,2953,1711，1646,1614,1603,1537,1457,1326,1162,1151/cm [a]D=-20.7e (CH3OH,C=1.01,2lt：). 本紙浪又度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) •裝_ 訂 線 513422 A7 B7 五、發明説明) 經濟部中央標準局員工消費合作社印製
No.l a — 9 8 CDC13 300MHz 0.93-2.00(14H,m),2.21(lH,m)>2.31(2H,t,J=7.2Hz),2.93(lH>m),3.84(3H,s),3.85( 6H,s),5.15-5.30(2H,m),5.45(lH,d,J=6.3Hz),7.04(2H,s),7.78-7.86(2H,m),7.90-7.： 98(2H,m),8.58(lH,s). IR(CHC13):3264,3008,2954,2874,1707,1670,1607,1537,1506,1451,1421,1308,1 158,1129,1088/cm. [a]D= -7.2° (CHC13,C=1.01,23.5t：). mp.147-149*0 No.l a - 9 9 CD30D 300MHz 1.04.1.98(14H,m),2.21(lH,m),2.10(2H,t,J=7.2Hz),2.95(lH,m),3.76(3H,s),3.86( 6H,s),5.07-5.24(2H,m),7.19(2H,s),7.99(2H,d,J=8.7Hz),8.13(lH,d,J=8.7Hz). IR(KBr):3354,3002,2950,2874,1656,1607,1570,1508,1452,1413,1314,1233,118 5,1157,1127,1092/cm. [〇f]D= ·20·3β (CH30H,C=1.00,23.5t：). No.l a - 1 0 0 CDC13 300MHz 1.14-1.97(14H，m)，2.19(lH,m)，2.28(2H，t，J=7.4Hz),3.04(lH,m)，3.69(3H,s),5.03( lH,d,J=6.9Hz),5.15-5.29(2H,m),7.65(2H,d,J=8.4Hz)>7.87(lHls),7.98(2H,dfJ=8. 4Hz). IR(CHC13):3386,3271,3025>3015,2955,2877,1755,1712,1608,1331,1162/cm. [c〇D= -29.4。（CH3OH，c=1.01，25t：)e No.l a ~ 1 0 1 d6-DMS0 1.00.2.20(17H，m)，2_84(lH，m)，5.00-5.20(2H，m)，7.78(2H，d，J=8.2Hz)，7.84(lH，s)， (請先閲讀背面之注意事項再本頁) -裝_ 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（2丨〇><297公釐） 129 A7 '發明説明（126 7·89·7·95(3Η,ιη)· IR(KBr):3269,3065,3008,2952,2874,2763,1746,17.07,1607,1322,1157 /cm. [〇：]D= ·26·2β (CH3OH,c=1.01,25t：)e No.l a - 1 0 2 CD30D 1.00-2.25(17H,m),2.92(lHfs),3.64(3H,s),5.07.5.21(2H,m),7.53(lH,s),7.77(2H,d, J=8.6H2),7.90(2H,d,J=8.6). IR(KBr):3430,3277,3006,2952,2873,1720,1687,1620,1571,1438,1312,1156 /cm. [a]D= -27.3° (ΟΗ30Η,〇=0.51,26Χ：). mp 230-232X： Νο·1 a - 1 0 3 CDC13 300MHz 0.94-1.96(14H,m),2.19(lH,m),2.28(2H,t,J=7.2Hz)f3.04(lH,m),3.69(3H,s),5.11( lH,d,J=6.6Hz),5.15-5.28(2H,m),7.60(2H,d,J=8.4Hz),7.67(lH,s),7.98(2H,d,J=8. 4Hz). IR(CHC13):3381,3021,2955,2876,1735,1605,1437,1411,1325,1231,1177 /cm. [a]D=+8.6° (0ΗΟ13,ο=1.00,23Χ：)〇 (請先閱讀背面之注意事項再頁) —裝· ^^本 、v'口 經濟部中央標準局員工消費合作社印製
No.l a — 1 0 4 CDC13 300MHz 0.94-1.96(14Hlm),2.21(lH>m),2.31(2Hlt,J=6.8Hz)l2.99(lHlm),5.18-5.28(2H,m), 5.45(lH,d,J=6.6Hz),7.61(2H,d,J=8.7Hz)l7.67(lHfs),7.99(2H,d,J=8.7Hz). IR(CHC13):3382,3222,3028,3019,2957,2876, Π36,1709,1604,1412,1322,1301,1 286,1179,1162 /cm. [a]D= +10.4〇 (CHCadOOW1^)·
No.l a - 1 0 5 本紙浪尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 130 513422 A7B7 五、發明説明（127 ) 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 0.92-1.98(14H,m),2.17(lH,m),2.26(2H.d,J=7.5Hz),3.01(lH,m),3.69(3H,s),4.01( 3H,s),4.84(lHfd,J=6.3Hz),5.14.5.30(2H,m),7.71(2H,d,J=8.7Hz),7.87(2H,d,J=8. 7Hz),8.09(lH,s). IR(CHC13):3385,3284,3025,3015,2954,2877,2821,1730,1598,1459,1438,1403,1 341.1160.1052 /cm. [a]D= +3.6。（CHC13,c=1.00,26t：)e No.l a - 1 0 6 CDC13 300MHz 0.92-2.08(14H,m)，2.14(lH,m),2.34(2H，d，J=7.2Hz),3.02(lH,m),4.01(3H，s),5.19( lH，d,J=6.9Hz),5.23-5.32(2H,m),7.71(2H,d,J=8.4Hz)，7.88(2H,d,J=8.4Hz),8.09( lH,s). IR(CHC13):3510,3384,3268,3028,3021,3014,2957,2877,2821,2667,2821,2666,1 707.1598.1459.1404.1341.1324.1160.1052 /cm. [a】D= +11.8。（CHC13,〇=1·01，25Χ：)· mp 95-96X： No.l a — 1 0 7 CDC13 300MHz 0.92-1.97(14H,m)>1.34(3Hft,J=7.2Hz),2.18(lH,m),2.28(2H.d,J=7.4Hz),3.01(lH, m),3.68(3H,s),4.26(2H,q,J=7.2Hz),4.86(lH,d>J=6.6Hz),5.15-5.29(2H,m),7.71(2 H,d,J=8.7Hz),7.87(2H,d,J=8.7Hz),8.09(lH,s). IR(CHC13):3385,3282,3025,3026,3015,2954,2877,1729,1599,1480,1458,1438,1 403,1338,1161 /cm. [a]D=+4.4° (CHC13,c=1.00,25t：)· No.l a — 1 0 8 CDC13 300MHz 0.90-2.04(14H,m)，1.34(3H,t,J=7.2Hz),2.14(lH，m)，2.34(2H，d，J=7.lHz)，3.01(lH, (請先閲讀背面之注意事項再本頁) 裝. 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 131 513422 A7 B7 五、發明説明（128 經濟部中央標準局員工消費合作杜印製 m)，4.27(2H，q，J=7.2Hz)，5.20(lH，d,J=6.6Hz)，5.21-5.35(2H，m),7.71(2H，d,J=8.4H z)f7.88(2H,d,J=8.4Hz),8.10(lH,s). IR<CHC13):3514,3384,3270,3025,3015,3015,2957,2877,1708,1599,1458,1403,1 324,1324,1160,1050 /cm. [a】D= +12.7。（CHC13,c=1.00,25t：)· No.l a — 1 0 9 [a]D=+8.5〇 (CHC13,c=1.00,25<C). mpl09.0-lll.0t： No.l a — 1 1 0 CDC13:CD30D(95:5) 0.92.2.06(14H,m),2.20(lH,m),2.30(2H,d,J=7.2Hz),2.99(lH,m),5.22.5.33(2H,m), 7.54.7.66(3H,m),8.07(2H,d,J=9.0Hz),8.12-8.20(2H,m),8.29(2H,d,J=9.0Hz). IR(Nujol):3270f2956,2924,2S54>1716,1548,1485,1319,1167/cm. [a]D=+17.0° (CHC13,c=1.00,25t：). mp. 166.5-168t： No.l a — 1 1 1 [a]D=+2.6° (CHC13,c=1.00,24t：)e mp 120.0-121.Ot： No.l a - 1 1 2 CDC13 300MHz 0.96.2.04(14H,m)f2.19(lH,m),2.33(2H,d,J=7.lHz),3.07(lH,m)r5.28-5.31(2H,m), 5.33(lH,d,J=6.6Hz)>7.54.7.63(3H,m),8.05(2H,d,J=8.4Hz),8.18-8.23(2Hlm)l8.41 (2H,d,J=8.4Hz). IR(CHCi3):3384,3269,3025,3015,2957,2877,1708,1598,1496,1457,14 17,1326,1 164 /cm. [a]D= +12.2° (CHC13，c=1.00,2‘lt：)· mp.163.164t： (請先閱讀背面之注意事項再Hi本頁) 裝-
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 132 513422 A7 B7 五、發明説明（129
No.l a — 1 1 3 [a]D= +22.1° (CHC13,c=1.05,25t：). mp.90-92t：
No.l a ~ 1 14 [a]D= +2·2β (CHC13，c=1.02,25t：)e
No.l a - 1 1 5 CDC13 300MHz 0.90-1.98(14H,m),2.15-2.22(lH,m)>2.27(2H,t,J=7.2Hz),2.95-3.04(lH,m), 3.68(3H,s),4.04(2H,s)f4.85(lH,d,J=6.6Hz)>5.10-5.27(2H,m),7.12- 7.34(7H,m),7.76-7.82(2H,m). IR(CHC13):3384,3026,2952,1727,1595,1493,1436,13 IS, 1155, l〇91,890/cm. [a]D==0· [a ]436=+4.9 ±0.4·
No.l a - 1 1 6 CDC13 300MHz 0.90-2.10(14H,m),2.10.2.18(lH,m),2.32(2H,t,J=7.2Hz),2.96-3.04(lHlm)l 4.04(2H,s)f5.14(lH,d,J=6.6Hz),5.16.5.28(2H>m),7.12.7.34(7Hfm),7.76- 7.82(2H,m). IR(CHC13):3260,3020,2950,1709,1407,1318,1154,1091,892/cm. [a]D==+9.1±0.5*(CHC13，c=1.04,23t：) 經濟部中央標隼局員工消費合作社印製
No.l a - 1 1 7 CD30D 300MHz 0.96.2.18(17H,m)f2.89-2.92(lH,m),4.05(2H,s),4.95-5.22(2Hfm),7.15- 7.42(7H,m),7.75-7.81(2H,m). IR(KBr):3429t3279,2951,2872,1563,U94,1453,1408,1313, i 155,1093,1057/c jD==· 16.3 土 0.5· (CH30H,c=l.06,25t：) 133 本纸浪尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 513422 A7 B7 五、發明説明（130 ) 經濟部中央標準局員工消費合作社印製
No.l a — 1 1 8 CDC13 300MHz 0.98-1.70(1δΗ,m), 1.8〇.2.00(5H,m),2.20-2.40(3H,m),2.98(lH,m),4.06(2H,s),4.7 2(lH，d,J=6.3Hz)，5.00-5.23(3H,m),7.16(2H，d，J=8.4Hz),7.26-7-33(5H,m)，7.79(2 H, d,J=8.lHz). IR(CHC13):3376,3020,2948,2868,1716,1596,1492,1453,1407,1318,1155,1105/c m. [a]D=+2.4° (CHC13,c=l.08,24t：). No.l a — 1 1 9 CDC13 300MHz ; 0.90-2.02(14H,m)f2.20(lH,m),2.29(2H,t,J=7.2Hz),3.00(lH,m),3.68(3H,s),4.86( lH,d>J=6.9Hz),5.13-5.34(2H,m),7.00-7.09(4Hlm),7.22(lHlm),7.37-7.45(2Hfm), 7.79-7.86(2H,m). IR(CHC13):3376,3018,2946,2868,1727,1582,1486,1321,1243,1151,1093 /cm. [a]D= +4.5° (CHC13,c=l.05,23.5t：)e No.l a - 1 2 0 CD30D 300MHz I. 00.2.00(14H>m),2.13(2H,t,J=7.5Hz),2.16(lH,m),2.91(lH>m),5.05-5.33(2H,m), 7.04-7.11(4H,m),7.18-7.25(lH,m),7.38.7.48(2H,m),7.80-7.87(2Hfm). IR(KBr):3430,3278,3006,2952,2873,1583,1487,1410,1322,1298,1245,1152,109 5 /cm. [crjD= -8.8。（CH30H，c=l.05,25.Ot：)· No.l a ~ 1 2 1 CDC13 300MHz 0.90-2.10(14H,m),2.15(lH,m),2.35(2H,t,J=7.2Hz),3.0i(LH,m),5.20(lH,d,J=6.9 (請先閱讀背面之注意事項再本頁) -裝_ 訂 線 本纸張尺度適用中國國家標準（CNS )八4規格（210X 297公釐） 134 513422 A7 B7 五、發明説明（131
Hz),5.22-5.35(2H,m),7.00-7.09(4H,m),7.18.7.25(lH,m),7.37-7.45(2H,m)f7.79-7. 86(2H,m)· IR(CHC13):3260,3020,2948,2868,1708,1582,1486,1409,1321,1296,1243,1151,1 093 /cm.
[a]D= +13.Γ (CHC13,c=1.04,24.0t：)e
No.l a — 1 2 2 CDC13 300MHz 0.90-2.00(14H,m)>2.23(lH,m)l2.28(2H,t,J=7.5Hz),2.96(lH,m),3.67(3H,s),4.69( lHtd,J=6.6Hz),5.15.5.32(2H,m),6.22(lH>s)>6.98-7.40(5H,m)>7.30-7.38(2H,m),7. 68-7.74(2H，m). IR(CHC13):3416,3370,3018,2946,2868,1725,1587,1508,1437,1400,1320,1149,1 094 /cm.
[a]D= +6.2° (011013^=1.04,25.0^:)0
No.l a - 1 2 3 CDC13 300MHz 0.90.2.04(14H,m),2.18(lH,m),2.33(2H,t,J=7.2Hz),2.96(lH,m),5.04-5.35(3H,m), 6.98-7.12(3H,m),7.12-7.20(2H,m)l7.28-7.38(2H,m),7.66-7.74(2H,m). IR(CHC13):3424,3270,3028,2952,2872,1708,1587,1508,1445,1399,1320,1148,1 092 /cm.
[or】D= +20.9。（CHC13，c=1.06,23.0*C)· 經濟部中央標準局員工消費合作社印製
No.l a — 1 2 4 CDC13 300MHz 0.90-2.00(14H,m)，2.18(lH，m)，2.28(2H,t，J=7.2Hz)，3.00(lH，m)，3.14(3H，s)，3.68( 3H，s)，4.56(2H，s)，4.84(lH，d,J=6.3Hz)，5.10-5.29(2H，m)，7.16-7.26(4H，m)，7.26-7. 34(2H，m)，7.78-7.84(2H，m)· IR(CHC13):3384,3028,2952,2874,1727,1598,1501,1435,1410,1370,1329,1172,1 135 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公瘦） 513422 A7 B7 五、發明説明（132 ) 經濟部中央標準局員工消費合作社印裝 145.1091 /cm. [a】D=+2.7°(CHC13,c=l.O9,23.0t：)· No.l a — 1 2 5 CDC13 300MHz 0.90-2.00(14H，m)，2.18(lH，m)，2.28(2H，t，J=7.2Hz),2.29(3H，s)，3.00(lH,m)，3.68( 3H,s),4.04(2H,s),4.S0(lH,d,J=6.6Hz),5.11-5.29(2H,m),6.99-7.06(2H,m),7.12-7. 19(2H,m),7.31(2H,d,J=8.lHz),7.79(2H,d,J=8.lHz). IR(CHC13):3382,3280,3024,2950,2S74,1730,1596,1504,1435,1407,1367,1318,1 196.1155.1091 /cm. [a]D= +2.9° (CHC13，c=1.06,23.0t：)e No.l a — 1 2 6 CDC13 300MHz 0.90-2.02(14H,m),2.14(lH,m),2.29(3H,s),2.32(2H,t,J=7.2Hz),3.01(lH,m),4.03( 2H,s),5.10(lH,dfJ=6.6Hz),5.15-5.30(2H,m),6.98-7.06(2H,m)(7.11-7.18(2H,m),7. 30(2H,d,J=8.lHz),7.79(2H,d,J=8.1Hz). IR(CHC13):3374,3260,3020,2948,2868,1749,1708,1596,1504,1407,1369,1317,1 195.1155.1091 /cm. [a]D= +10.0° (CHC13，c=1.09,23.0t：)e No.l a - 1 2 7 CDC13 300iMHz 0.87.1.95(14Htm),2.18.2.32(3H,m),2.95(lH,m),3.69(3H,s),3.96(2H,s),4.79(lH, d,J=6.6Hz),4.97.5.17(2H,m)f5.54(lH,s),6.75-6.82(2H,m),6.97.7.05(2H,m),7.25-7.33(2H,m),7.75-7.81(2H,m). j j IR(CHCi3):3382,3026,2950,2874,1722,1595,151 1,U36,1407, L3 17,1257, LI 54.1 090 /cm. [ajD二-2.1a (CHCl3.c=1.00,21.5t：)e (請先閱讀背面之注意事項再本頁) 裝_ 訂 線 本紙浪尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 136 513422 A7 B7 五、發明説明（133 請 先 閱 讀 背 δ} 5 意 事 項
No.l a - 1 2 8 CDC13 300MHz 0.85-2.02(14H，m)，2.18(lH,m),2.31(2H,t,J=7.2Hz)，2.96(lH，m)，3.95(2H，s)，5.05- 5.27(3H,m),6.73.6.82(2H,m),6.96-7.04(2H,m),7.25-7.32(2H,m),7.74-7.81(2H,m )· IR(CHC13):3262,3020,2948,286S, 1708,1596, loll, HOT, 1315,1242,1154,1091 / cm.
[a]D=+4.8〇 (CHC13,c=1.04,22t：).
No.l a — 1 2 9 CDC13 300MHz 0.89-1.98(14H,m),2.18(lH,m),2.27(2li,t,J=7.2Hz),2.99(lH,m),3.6S(3H,s),3.79( 3H,s),3.98(2H,s),4.81(lH,d,J=6.6Hz)>5.10-5.27(2H,m),6.81-6.87(2H>m)>7.03-7. 10(2H,m),7.25-7.32(2H)m),7.75-7.82(2H,m). IR(CHC13):3382,3276,3006,2950,2874,1726,1609,1509,1457,1436,1407,1315,1 244,1154,1091,1033/cm.
[a]D=+19.3〇(CHC13，C=1.05,23t：)· iMo.l a - 1 3 0 CDC13 300iMHz 經濟部中央標準局員工消費合作社印製 0.90-2.00(14H，m)，2.20(lH，m)，2.30(2H，t，J=7.2Hz)，2.9S(lH，m)，3.69(3H，s)，4.81( lH，d，J=6.6Hz)，5.12-5.32(2H，m)，5.46(lH，brs)，6.84-7.01(6H，m)，7.76-7.83(2H，m) IR(CHC13):3380,3284,3024,2952,2874,1724,1588,1504,1488,1436,132 1,1296,1 149r1091/cm.
[ajD:+28.9。（CHCl3，C:1.01，23t：).
No. L a — 1 3 1 CDC13 300MHz 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 137 513422 A7 B7 五、發明説明（134 ) 0.92-2.10(14H,m),2.18(lH,m),2.34(2H,t,J=€.9Hz),2.96(lH,m),5.18-5.35(3H,m), 6.84-7.01(6H,m),7.75.7.83(2H,m). IR(CHC13):3270,3028,2952,2874,1708,1589,1505,1489,1456,1322,1297,1238,1 148,l〇91/cm.
[a]D=+7.7e (CHC13，C=1.09,24t：)·
No.l a — 1 3 2 CDC13 300MHz 0.91-2.02(14H,m),2.19(lH,m),2.29{2H,t,J=7.2Hz),2.99(lH,m),3.6S(3Hts),3.83( 3H,s),4.82(lH,d,J=6.6Hz),5.14-5.33(2H,m),6.90-7.04(6H,m),7.76-7.83(2H,m). IR(CHC13):3384,3006,2952,2874,1727,1589,1502,1488,1459,1438,132 1,1295,1 231,1150，1092,1033/cm. (α]Ό=+3.Γ (CHC13,C=1.01,23X：).
No.l a - 1 3 3 TLC Rf=0.21 (醋酸乙酯·· n-己烷=1 : 1(0.3%賭酸>):
No.l a - 1 3 4 CDC13 300MHz 0.97-2.10(14H,m),2.20(lH,m),2.36(2H>t(J=6.9Hz),3.04(lHtm),5.22-5.33(2H,m), 5.41(lH，d，J=6.6Hz)，7.02(lH，d，J=9.0Hz)，7.09-7.13(2H，m),7.26-7.32(lH,m)，7.43 • 7.49(2H，m)，7.93<lH，d.d，J=2.4and9.0Hz),8.46(lH，d，J=2.4Hz). 經濟部中央標準局員工消費合作社印製 IR(CHC13):3334,3270,3020f2958f 1709,1610,1587,1537,1479,1352,127 1,1252,1 167/cm.
[a]D=+20.9° (CHC13,C=0.51,22t：).
No.L a - 1 3 5 、 CDC13 300MHz 0.9G-2.02(14H,m)t2.21(lH,m),2.29C2H,t,J=7.2Hz),3.07(LH,m),3.68(3H,s),5.04( 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） -138 - 513422 A7 B7 五、發明説明（135 經濟部中央標準局員工消費合作社印製 lH,d,J=6.9Hz),5.16-5.33(2H,m),7.48-7.55(2H,m),7.64(lH,m),7.76.7.82(2H,m), 7.88-7.94(2H,m)f7.98-8.04(2H,m). IR(CHC13):3384,3282,3026,2952,2874,1727,1663,1596,1446,1396,1316,1274,1 163,1090 /cm. [a】D= +3·Γ (CHC13，c=l.03,22.Ot：)· No.l a - 1 3 6 CDC13 300MHz 0.95-2.05(14H，m)，2.19(lH，m),2.34(2H，t，J=7.2Hz)，3.08(lH，m)，5.10-5.40(2H，m)， 5.35(lH,d,J=6.8Hz),7.45-7.58(2Hfm),7.64(lH,m),7.74.7.84(2Hlm),7.84-7.95(2 H,m),7.95-8.06(2H,m). IR(CHC13):3260,3018,2950,2870,1708,1662,1595,1446,1395,1316,1274,1162,1 090 /cm. [a]D二 +12.9。（CHC13，c=1.05,21.5t：)。 No.l a - 1 3 7 CDC13 300MHz 0.97-2.04(14H，m)，2.27(lH，m)，2.31(2H，t,J=7.2Hz)，3.07(lH,m)，3.70(3H，s)，5.15· 5.30(3H,m),7.48-7.68(5H,m),7.96-8.02(2H,m). IR(CHC13):3382,3030,2952>2878,1725,1446,1329,1154,1098 /cm. [a]D= -12.1° (CHCi3,c=1.03,22.0t：)e No.l a - 1 3 8 CDC13 300MHz 0.95-2.04( 2,25( lH,m)，2.35(2H，t，J=7.2Hz),3.08( lH，m)，5· 15-5.34(2H，m), 5.41(lH,d,J=6.6H2),7.48-7.68(5H,m),7.98-8.03(2H,m). IR(CHC13):3370,3242,3022,2950,2870,1707,1445,1408,1329.1154,1099 /cm. [c^D二，O.G〇 (CHCl3，c=l.〇6.2l.5t：) M3G5 +30.7。（(：Η(：13.π1·06,21·5Γ). ： ： 扯衣-- (請先閱讀背面之注意事項再||||>本頁) 、11 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 139 五 、發明説明（ 136 A7 B7 經濟部中央標準局員工消費合作社印製
No.i a - 1 3 9 CDC13 300MHz 0.92-2.19(14H,m),2.27-2.34(3H，m),3.26(lH,m),3.65(3H，s),4.28(2H，s)，4.37(lH, d,J=7.4Hz),5.34-5.50(2H,m),7.37.7.62(9H,m). IR(CHC13):3389,3294,3028,3015,2954,2877,1730,1600,1488,1325,1151,1129 / cm. [a]D= -24.8° (CHC13,C=1.01，24t：)e No.l a — 1 4 0 CDC13 300MHz 0.92-2.22(15H,m),2.34(2H,t>J=7.lHz),3.24(lH,m),4.29(2H,s),4.81(lH,d,J=7.4H z),5.32-5.52(2H,m)f7.36.7.62(9H,m). IR(CHC13):3510,3388,3251,3031,3015^2956,2877,2668,1708,1601,1488,1318,1 151,1129 /cm. [a]D= -24.6° (CHC13,c=1.02,25t：)e No.l a - 1 4 1 CDC13 300MHz 0.92-2.19(15H，m)，2.32(2H，t，J=7.2Hz)，3.26(lH，m)，3.65(3H，s),4.31(2H，s)，4.48(l H，d，J=7.4Hz)，5.33-5.49(2H，m)，7.42-7.80(8H，m). IR(CHC13):3388,3285,3018,2955,2877,2225,1730,1597,1479,1320,1152,1129 / cm. [a]O= -20.Γ (CHC13),c=0.96,25t：). No.l a - 1 4 2 CDC13 300MHz 0.92.2.22(15H,m)l2.35(2H,t,J=6.8Hz),3.25(lH,m),4.32(2H,s),4.86(lH,d,J=7.4H z),5.33-5.53(2H.m),7.43-7.80(8FI,m). IR(CHC13):35 12,3388,3258,303 1,3023,30 14,2956 2377,2225,1708,1597, U79, 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) 裝. 訂 綠 140 513422 經濟部中央標準局員工消費合作社印製 A7 B7五、發明説明（137) 1319,1151,1128 /cm. [a]D= ·19·3。（CHC13,c=：L09,23t：)· No.l a — 1 4 3 CDC13 300MHz 1.00-1.93(14H,m),2.17(lH,m)>2.27(2H,t,J=7.2Hz),3.07(lH,m),5.17-5.22{2H,m), 5.36(lH,d,J=6.9H2),7.77(lH,d,J=9.0Hz),8.11-8.17(2H,m),8.36(lH,d.d,J=2.1an d9.0Hz),8.51(lH,d,J=1.8Hz),8.65(lH,d,J=2.lHz). IR(CHC13):3382,3266,3026,2954,2874,1708,1632,1585,1528,145s, 1419,1345,1 153/cm. [a]D=+7.6〇 (CHC13,C=1.04I22<C). No.l a - 1 4 4 ' CDC13 300MHz 0.95-1.90(14H,m),2.17(lH,m),2.25(2H,t,J=T.5Hz),3.02(lH,m),5.09(lH,d,J=6.6 Hz)>5.15-5.21(2H,m),6.72(lHfd,J=8.4Hz),6.85(lH,s),7.54(lH,d,J=S.4Hz)f7.72( lH,d,J=9.0Hz),7.83(lH,d.d,J=1.8and9.0Hz)f8.32(lH,d,J=1.8Hz). IR(CHC13):3380,3260,3022,2948,2868,2352,1709,1636,1460,1425,1313,1291,1 265,1148,1130/cm. [a]D=+12.9〇 (CHC13,C=1.02,22.5t：). No.l a - 1 4 5 CDC13 300MHz 0.97.1.90(14H,m),2.15(lH,m)f2.27(2HtttJ=6.9Hz),3.02(lH,m)>3.0S(6Hls),5.12( lH，d,J=6.3Hz),5.19-5.25(2H，m),6.78.6.84(2H,m)，7.53(lH，d，J=8.7Hz),7.76-7.83 (2H,m)，8.30(lH，d,J=1.8Hz). IR(CHC13):3272,3030f2950,2874,1708,1635,1601,15 11,1457,1425,1357,1328,1 151,U24/cm. [aJD=+6.3〇 (CHCi3,C=L.04,23t：). (請先閱背面之注意事項再本頁) •裝_ 訂 線一 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 141 513422 A7 B7 五、發明説明（138) 經濟部中央標隼局員工消費合作社印製
No.l a - 1 4 6 CDC13 300MHz 0.95-2.00(14H,m),2.16(lH,m),2.29(2H,t,J=7.2Hz),3.05(lH,m),4.10(3H,s),5.13. 5.28(2H,m),5.38(lH,d,J=6.9Hz),7.67-7.74(2H,m),8.08(lH,d.d,J=1.8and9.0Hz), 8.11(lH,s),8.61(lH,d,J=1.8Hz). IR(CHC13):3260,3020,2948,2868,1708,1639,1606,1528,1470,1455,1424,1349,1 311,1238,1174,1149,H20,1079,l〇60,1022/cm. [a]D=+7.8〇 (ΟΗ013,0=1.00,23Χ：). No.l a — 1 4 7 CDC13 300MHz 0.92-1.92(14H,m),2.17(lH,m),2.25(2H,t,J=7.2Hz),3.01(lH,m),3.97(3H,s)l5.10< 5.27(5H，m)，6.92(lH，s),7.29(lH,s),7.52(lH,d,J=8.7Hz),7,82(lH,d.d,J=2.1and8· 7Hz),8.33(lH,d,J=2.1Hz). IR(CHC13):3380,3264,3002,2950,2868,1708,1634,1476,1452,1426,1317,1264,1 218,1169,1147,1115,1068,1031/cm. [a】D=+5.6。（CHC13，C=1.02,23t：)· No.l a — 1 4 8 CDC13 300MHz 0.9(M.98(14H，m)，2.15(lH，m)，2.28(2H，t,J=6.9Hz),2.91(6Hs)，3.03(lH，m),4.01(3 Hfs),5.15-5.26(3H>m),7.18(lH,s),7.38(lH,s),7.59(lH,d,J=8.7Hz),7.87(lH,d.d,J =2.1and8.7Hz),8.40(lHtd,J=2.lHz). IR(CHC13):3384,3266,295611709,1632,1602,1495,1473,1458,1430,1317,1231,1 148,1121/cm. [a】D=+11.20 (CHC13，C=1.01，23r). No.l a - 1 4 9 (請先閱讀背面之注意事項再本頁) |裝· 太 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 142 513422 A7 B7 五、發明説明（139 ) CDC13 300MHz 0.99-1.90(14H，m)，2.17(lH，m)，2.28(2H，t,J=7.2Hz)，3.00(lH，m),5.13-5.19(2H，m), 5.43(lH,d,J=6.0Hz),7.02(lH,d.d,J=2.4and9.0Hz),7.38.7.41(2H,m),7.58(lH,d,J ! =8.7Hz),7.96(lH,d.d,J=1.8and8.7Hz),8.45(lH,d,J=1.8Hz). IR(CHC13):3270,3020,2948,2868,1709,1601,1478,1448,1419,1315,1147,1120/c m. [a]D=-11.4。（CHC13，C=1.01，23t：). No.l a — 1 5 0 CDC13 300MHz 0.97-1.8S(14H,m),2.12.2.31(3H,m),2.38(3H,s),3.01(lH,m),5.14.5.19(2H,m),5.3 6(lH,d,J=6.6Hz),7.24(lH,d.d,J=2.4and9.0Hz)>7.59(lH,d,J=6.3Hz),7.66(lH,d,J =8.7Hz),7.72(lH,d,J=2.4Hz),8.01(lH,d.d,J=1.8and8.7Hz),S.49(lH,d,J=l.SHz). IR(CHC13):3470,3374,3260,3018,2950,2868,1709,1474,1444,1412,1370,1319,1 266,1162,1145,1118/cm. [a]D=+4.9° (CHC13，C=1.00,24t：). (請先閱讀背面之注意事項再本頁) -裝- 訂 經濟部中央標準局員工消費合作社印製
No.l a — 1 5 1 CDC13 300MHz 0.97-1.89(14H，m)，2.17(lH,m)，2.25(2H，t，J=7.2Hz),3.03(lH，m)，3.92(3H，s)，5.15- 5.20(2H,m),5.32(lH>d,J=6.6Hz),7.11(lH,d.d,J=2.4and9.3Hz),7.45(lH,d,J=2.4 Hz),7.50(lH,d,J=9.3Hz),7.62(lH,d,J=8.7H),7.97(lH,d.d,J=2.1and8.7Hz),8.50( !H,d,J=2.lHz). IR(CHC13):3260,3018,2948,1708,1483,1454,1432,1314,1287,1268,1188,1169,1 147/cm. [a]D=+4.9。（CHC13,C=1.01,23.5t：).
No.l a - 1 5 2 CDC13 300MHz 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 線 143 513422 A7 B7 五、發明説明（14Q ) 0.98-2.04(i4H，m),2.15(lH，m)，2.30(2H，t,J=6.6Hz)，3.04(lH，m)，5.17-5.29(3H，m)， 7.41(lH，d.d，J=1.5and8.1Hz)，7.64-7.68(2H，m)，7.92(lH，d，J=8.4Hz)，8.00(lH，d.d， J=1.8and8.4Hz),8.49(lH,d,J=1.8Hz). IR(CHC13):3266,3028,2952,2872,1707,1629,1591，1456,1416,1318,1275,1150/c m.
[a]D=+3.2° (CHC13,C=1.04,23t：).
No.l a — 1 5 3 CDC13 300MHz 0.97-1.88(14H,m),2.16(lH,m),2.26(2H>t,J=/7.2Hz),3.03(lH,m),4.64.4.65(2H,m), 5.16.5.50(5H>m),6.13(lH,m),7.14(lHld.d,J=2.7and9.0Hz),7.46.7.52(2H,m),7.6 3(lH,d，J=8.7Hz)，7.97(lH,d.d，J=1.8and8.7Hz)，8.49(lH,d，J=1.8Hz)· IR(CHC13):3374,3260,3020,2948,2868,1708,1599,1478,1446,1414,1314,1284,1 268,1184,1148,1120/cm.
[cr]D=+5.3。（CHC13，C=1.00,23t：)·
No.l a - 1 5 4 CDC13 300MHz 0.99-2.00(15H，m)，2.26(2H，t，J=7.2Hz),3.03(lH，m),4.07(3H,s)，5.23-5.27(2H，m), 5.36(lH，d，J=7.2Hz)，7.20(lH，s)，7.36-7.48(2H，m)，7.55-7.58(lH，m)，7.91.7.93(lH, m)，8.52(lH，s)· 經濟部中央標準局員工消費合作社印製 (請先閱讀背面之注意事項再本頁) IR(CHC13):3362,3257,3020,2948,2868,1708,1637,1602,1579,1488,1457,1437,1 413,1345,1318,1301,1276,1182,1104/cm.
[a】D= +19.4° (CHC13，C=1.01，25\：). mp.88-90t：
No.l a ~ 1 5 5 CDC13 300MHz 0.92.2.02(14H,m),2.15(lH,m),2.31(2H,t,J = 7.2Hz)(3.01(lH,m),4.10(2H,s),5.10( 本紙浪尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 144 513422 A7 B7 五、發明説明（141 經濟部中央標準局員工消費合作社印製 lH,d,J=6.6Hz),δ. 18-5.35(2H,m),7.04-7.26(5H,m),7.67-7.76(2H,m). IR(CHC13):3266,3028,2952,2952,2872,1708,1599,1574,147S, 1457,1418,1301,1 258,1147,1124,1101,1080/cm. [a]365 +33.4e(CHC13,O1.00,23t：)· No.l a — 1 δ 6 CDC13 300MHz 0.91-2.21(15H，m)，2.33(2H，t，J=6.9Hz),3.01(lH，m)，5.11(lH,d，J=6.6Hz),5.27-5.3 5(2H,m),6.85-6.96(5H,m),7.35(lH,d,J=2.lHz),7.42(lH,d.d,J=2.1and8.7Hz). IR(CHC13):3384,3263,2957,1708,1587,1489,1462,1416,1290,1222,1151,1123/c m. (a]D=+6.4° (CHC13,C=1.00,23t：). _No.l a — 1 5 7 CDC13 300MHz 0.97-1.91(14H,m),2.18(lH,m),2.26(2H,t,J=6.9Hz),3.04(lH,m),5.1S-5.26(3H,m), 7.52-7.56(2H,m),7.88-8.00(3H,m)>8.25(lH,m)>8.69(lH,m). IR(CHC13):3382,3268,2952,2874,1707,1457,1425,1409,13 IS, 1152/cm. [a]D=+4.4〇 (CHC13,C=1.02,22t：). No.l a — 1 5 8 CDC13 300MHz 1.02-1.97(14H,m),2.20(lH,m),2.29(2Hft,J=7.2Hz),3.06(lHfm),5.19-5.24(2H,m), 5.58(lH,d,J=6.6Hz),7.62(lH,m),T.72(lH,m)f7.86.7.91(2Hfm),7.96(lH,dfJ=7.8H z),8.04(lHld.d,J=1.5and8.lHz)f8.34(lHld,J=1.2Hz). IR(CHCi3):3490,3260,3020,2950,2870,1707,1456,1399,13 12.1 165/cm. [a】D二-8.3° (CHC13,C=1.00,23t：).
No.l a 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再^!^本頁) .裝- 、^7 絲 145 513422 A7 B7 五、發明説明（142 ) 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 0.92.1.88(14H，m)，2.13(lH，m)，2.24(2H，m)，3.02(lH,m)，3.90(3H,s)，5.12-5.26(3H， m),7.29-7.58(4H,m),7.97(lH,d.d,J=1.8and7.5Hz),8.13(lH,d,J=7.5Hz),S.64(lH, d，J=1.8Hz). IR(CHC13):3382,3266,3018,2956,1708,1629,1594,1476,1467,1325,1245,1227 ,1158,1146/cm. [a]D=+14.6〇 (CHC13，C=1.00,22t). Νο·1 a - 1 6 0 CDC13 300MHz 0.93-l.SS(14H,m),2.18-2.24(3HJm),3.00(lH,m),5.08-5.21(3H,m),7.28-7.33(lH, m),7.47-7.51(3H,m),7.90(lH,d.d,J=1.5and7.8Hz),8.10(lH,d,J=7.8Hz),8.63-8.64 (2H，m). ’ IR(CHC13):3465,3380,3275,3020,2957,2876,1708,1627,1604,1495,1473,1457,1 328,1240,1222,1156,1149/cm. [a]D=+8.2° (CHC13,C=1.01,22=). No.l a — 1 6 1 CDC13 300MHz 0.98-1.88(14H，m)，2.17(lH，m)，2.24(2H，t，J=7.2Hz)，3.05(lH，m)，5.16-5.20(2H，m)， 5.35(lH，d,J=6.6Hz)，7.40(lH，m)，7.55(lH，m)，7.63(lH，d，J=8.lHz)，7.89(lH，d.d，J = 1.5and8.lHz)，8.01(lH，m)，8.06(lH，d，J=8.1Hz)，8.12(lH，d，J=1.5Hz). IR(CHC13):3478,3266f3028,2952,2874,1708,1454,14 17,1323,1196,1148/cm. [a]D=+21.9° (CHC13,C=1.01,23t：). No.l a - 1 6 2 CDC13 300MHz 0.96-1.98(14H,m)l2.02(lHfm)f2.25(2H,t,J=7.2Hz),3.05(lH,m)>4.10(3H,s),5.i4- 5.25(2H,m),5.41(lH,d,J=7.2Hz),7.35-7.42(lH>m),7.51-7.G4(3H,m)17.94.8.00(i --Γ--.------¾衣-- (請先閱讀背面之注意事項再本頁) 訂 •4- 本纸痕尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 146 513422 A7 B7 五、發明説明（) 經濟部中央標準局員工消費合作社印製 H,m)，8.16(lH，s)· IR(CHC13):3368,3274,3028,2952,2874,1708,1633,1583,1465,1452,1438,1413,1 315,1151,ll〇3,1053,l〇24/cm. [a]D= +15.1° (CHC13,0=1.01,23t：). mp.l08-ll〇X： No.l a — 1 6 3 d6-DMSO 300MHz 0.97-L84(14H,m),1.92(lH,m)>2.04(2H,t,J=7.5Hz)>2.90(lH,m),5.0S*5.23(2H,m), 7.32(lH,s),7.38-7.61(2H，m),7.62(lH，s)7.68-7.71(lH，m)，7.92(lH，s)，8.14-8.17(l H，m),10.7(lH,s)，11.9(lH，s). IR(KBr):3350,3295,2952,2874,1707,1636,1601,1466,1431,1389,1315,1251,117 4,1146,1106/cm. [α)Ώ= -25.3° (CH30H,0=1.01,25^)： mp.l59-162t： No.l a — 1 6 4 CDC13 300MHz 0.9S-L96(17H,m),2.05(lH,m),2.25(2H,t,J=7.2Hz),3.07(lH,m),4.32(2H,q,J=7.2 Hz)，5.19-5.23(2H,m)，5.31(lH,d，J=7.8Hz)，7.38(lH，m)，7.41-7.62(3H，m)，7.95(lH， m)，8.15(lH,s). IR(CHC13):3360,3018,2946,2870,1709,1633,1457,1445,1425,1394,1314,1176,1 152,1105/cm. [a]D= +12.7° (CHC13,C=1.02,25r). mp.l08-109t： No.l a - 1 6 5 CDC13 300MHz 0.95-1.98(15H,m),2.26(2Htt,J=7.5Hz)t3.04(lH,m),4.15(3Hrs),5.20-5.2G(2Hfm)f 5.34(1Η,ά^=6.9Ηζ),7.41-7.47(1Η,πι),7.65-7.68(2Η,πι),7.89.7.92(ΐΗ,πι),8.32(1 H,s). iR(CPiCl3):3366,3087,3022,2957,1708,1632,1538,1463, L408,1364,13*IG, 1308,1 (請先閲讀背面之注意事項再本頁) •裝· 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 147 513422 Μ Β7 五、發明説明（144 227,1212,1205,1167/cm.
[a]D= +19.6。（CHC13，C=1.01，25t：)·
No.l a - 1 6 6 CDC13 300MHz 0.97-2.02(15H,m),2.27(2H,t,J=6.9Hz),3.07(lH,m),4.14(3H,s),5.21-5.27(2H,m), 5.47(lH,d,J=6.9Hz),7.64(lH,s),7.72(lH,d.d,J=0.6and9.0Hz),8.25(lH,s),8.47(l H,d.d,J=2.4and9.0Hz),8.94(lH,d<d,J=0.6and2.4Hz). IR(CHC13):3373,2957,1708,1639,1587,1528,1467,1428,1415,1345,1221,1184,1 155/cm.
[a]D= +14.4° (CHC13,C=0.50,25t：)
No.l a - 1 6 7 CDC13 300MHz 0.92.2.00(14H,m),2.15(lH,m),2.27(2H,t,J=7.2Hz)f3.04(lH,m),3.97(2H,s),5.15- 5.30(3H,m),7.35-7.47(2H,m),7.55-7.63(lH,m),7.80-7.96(3H,in),8.05(lH,d,J=0.3
Hz). IR(CHC13):3260f3020,2948,2868,1707,1451,1413,1319,1172,1144,1101, l〇71/c m· [a]D=+18.2° (ΟΗ013,0=1.04,22Χ：).
No.l a - 1 6 8 CDC13 300MHz 經濟部中央標隼局員工消費合作社印製 0.90-1.88(14H,m),2.16(lH,m),2.25(2H,tfJ=6.9Hz),3.00(lH,m),5.00.5.19(2H,m), 5.35(lH,d,J=6.6Hz),7.25-7.30(lH,m),7.48-7.50(2H,m),7.73(lH,d.d,J=1.5and8. 1Hz),8.08-8.14(3H,m),8.93(lH,s). IR(CHC13):3466,3380,3276,3016,2957,1708,1630,1495,1458,1324,124 lf1150/c m.
[a]D=+18.0° (CHC13,0=1.00,22^). 148 本紙張尺度適用中國國家標準（CNS ) A4規格（2丨〇'乂 297公釐） 513422 A7 B7 五、發明説明（145 ) 經濟部中央標準局員工消費合作社印製
No.l a - 1 6 9 CDC13 300MHz 0.87-1.86(14H,m),2.15(lH,m),2.25(2H，t,J=6.9Hz),2.98(lH,m)，3.89(3H，s),5.00· 5.22(2H,m),5.27(lH,d,J=6.9Hz),6.88(lH,d.d,J=2.1and8.4Hz),6.94(lH,d,J=2.1 Hz),7.69(lH，d.d,J=1.5and7.8Hz)，7.92-8.01(3H,m),8.83(lH,s). IR(CHC13):3465,3378,3276,3022,2957,1708,1630,1609,1569,1459,1433,1314,1 281,1229,1151/cm. [a]D=+19.3° (CHC13,C=1.01,21^：). No.l a - 1 7 0 CDC13 300MHz 0.88-2.25(17H,m),3.04(lH,m),3.84(3H,s),3.95(3H,s),5.06-5.26(3H,m),6.87-6.93 (2H,m),7.69(lH,d.d,J=1.6and8.2H2),7.93-9.05(3H,m). IR(CHC13):3026,2957,1708,1630,1601,1460,1331,1243,1224,1152/cm. [a]D=+17.2e (CHC13,C=1.00,22t：). No.l a - 1 7 1 CDC13 300MHz 0.95-2.00(14H,m),2.16-2.32(3H,m),2.66(3H,s),3.14(lH,m),3.68(3H,s),5.09(lH, d,J=6.8Hz)，5.10-5.28(2H，m)，7.45(lH，d.d”J=1.8&8.6Hz)，7.75-7.84(2H,m). IR(CHC13):3374,3018,2946,2868,1725,1585,1513,1436,1340,1278,1153,1112 / cm. [a]D= -14.7° (ΟΗΟ13,ο=1.07,25.0Χ：).
No.l a - 1 7 2 CDC13 300MHz 0.97-2.02(14H，m)，2.23(lH，m)，2.28(2H，t，J=7.2Hz)，2.66(3H，s)，3.14(lH，m)，5.12· 5.22(2H,m)f5.41(lH,dlJ=7.2Hz),7.45(lHld.d.,J=2.1&8.7Hz),7.76(lH,d,J=8.7Hz 本纸浪尺度適用中國國家標準（CNS ) A4規格（210X297公釐） ——：——，------^—— (請先閱讀背面之注意事項再本頁) 線 149 W3422 A7 B7 五、發明説明（146 ) ),7.78(lH,d,J=2.lHz). IR(CHC13):3372,3250,3022,2950,2868,1707,1514,1419,1336,1279,1154,1112 / cm.
[α]Ό= -4.1° (CHC13,c=1.08,26.0t：) m.p.l4M43t：
No.l a — 1 7 3 CDC13 300MHz
1.15-2.42(17H,m),2.91(lH,m),5.15(lH,d,J=4.2Hz),5.25-5.40(2H,m),7.85(lH,t,J =7.2Hz),8.00(lH,t,J=8.lHz)，8.15-8.20(2H,m),8.67(lH,d,J=8.lHz)，8.73(lH，d，J= 8.1Hz),8.83(1H,s),9.43<1H,s). IR(KBr):3422,3269,3046,2952,2871,1711,1617,1447,1333,1243,1161,1146/cm.
[a】D:41.0〇 (CH3OH,C=1.01,23t：)· *
No.l a - 1 7 4 CDC13+d6-DMSO 300MHz 1.00-1.92(14H，m)，2.20(2H，t，J=6,6Hz)，2.35(lH，m)，2.92(lH，m)，5.05-5.22(2H，m)， 6.63(lH,d,J=5.4Hz),7.77-7.92(3H,m),8.31(lH,d.d,J=1.8and8.7Hz)f8.59(lH,d(J =8.7Hz),8.73(lH,d,J=8.7Hz),9.01(lH,s),9.55(lH,d,J=1.8Hz). IR(KBr):3433,3252,2952,2871,1696,1578,1423,1335,1308,1219,1185,1160,110 6/cm.
[a]D=-19.3。（DMSO，C=0.50,23t：)· 經濟部中央標準局員工消費合作社印製
No.l a ~ 1 7 5 CDC13 300MHz 0.96-1.87(14H，m),2.20,2.25(3H，m)，2.95(lH，m),3.66(3H，s)，‘i.7‘i(lH.d,J=6.GHZ),: 5.10-5.12(2H,m),6.88(lH,d,J=1.2Hz),7.37-7：50(3Hfm),7.56(LH,dd,J=8.7fI.5Hz)J 7.68-7.77(3H,m),8.06(lH,s),9.44(lH,dd,J=1.2Hz). IR(CHC 13):3462,3374,3026,3006,2952,2872,1724,16 10,1580, M84,1452,1358,1 本纸張又度適用中國國家標準（CMS ) A4規格（210X297公釐） 150 513422 A7 B7 五、發明説明（147 ) 經濟部中央標準局員工消費合作社印製 309,1147. [a]D=+16.4° (CHC13,c=1.05,26t：). mp.l30-132t：. No.l a - 1 7 6 CDC13+CD30D 300MHz 1.00.2.02(14H,m),2.22(lH,m),2.29(2H,t,J=6.9Hz),2.88(lH,m),5.16-5.26(2Hlm ),6.87(lH,s),7.28-7.57(4H,m),7.69(lH,d,J=8.4Hz),7.75-7.78(2H,m),7.99(lH,s). IR(KBr):3254,2944,1704,1484,1453,1358,1305,1147. [a]D=+13.0° (CH3OH,c=1.02,24t：), mp.l60-16lX： No.l a - 1 7 7 CDC13 300MHz ·: 0.96-L88(14H,m),1.88-2.26(3H,m),2.94(lH,m),3.67(3H,s),3.87(3H,s),4.67(lH, brs),5.08-5.14(2H,m),6.77(lH,d,J=1.5Hz),6.99-7.02(2H,m),7.53-7.57(lH,m),7.6 5-7.70(3H,m),8.00(lH,s),9.27(lH,brs). IR(CHC13):3426,3376,3006,2952,1724,1610,1495,1438,1357,1308,1282,1249,1 177,1147/cm. [a]D=+18.1〇 (CHC13，C=1.02,22t：). No.l a - 1 7 8 CDC13+CD30D 300MHz 0.96-1.91(14H,m),2.19(lH,m)?2.27(2H,tlJ=6.0Hz),2.85(lH,m),3.87(3H,s),5.16-5.23(2Hfm),6.99-7.02(2H,m)>7.41(lH,m),7.64-7.73(3H,m)>7.92(lH,m). IR(CHC13):3366,3261,3004,2954,2873,1705,1611,1496,1458,1438,1304,1286,1 253,1180,1149,1128/cm. [ap二+14.60 ((^13,0=1.02,22=). No.l a - 1 7 9 CDC13+CD30D 300MHz (請先閱讀背面之注意事項再本頁) 訂 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 151 513422 A7 B7 五、發明説明（148) 0.96-1.87(14H，m),2.15-2.23(3H，m)，2.93<lH，m)，3.85(3H,s)，5.10;16(2H，m),6.9 〇.6.93(2H>m),7.50(lH,m),7.60-7.65(3H,m)>7.91(lH,d,J=0.9Hz). IR(CHC13):3369,3270,2950,2373,1719,1612,1498,1456,1440,1359,1306,1269,1 219,1146,1127/cm. [a]D=+18.1° (CH30H,C=1.00,22t：). No.l a — 1 8 0 CDC13+CD30D 300MHz 1.03-l.S6(14H,m),2.08.2.17(3H,m),2.91(lH,m),5.06-5.10(2H,m),6.76(lH,m),6.8 6-6.90(2Η,ιη),7.48(ΐΗ,πι),7.61-7.69(3Η,πι),7.89(ΐΗ,ιη). IR(CHC13):3360,3259,2954,2873,1706,1612,1497,1457,1360,1306,1272,1230,1 176,114S,1126/cm. [a]D=+20.3° (CH30H，C=1.00,22t：). No.l a — 1 8 1 CDC13 300MHz 0.97-1.96(14Hfm)f2.15(lH,m),2.29(2H,t,J=6.9Hz),3.05(lH,m),3.Sl(3H,s),5.0S( lH,d,J=6.9Hz)>5.23-5.25(2H,m),6.62(lH,s)f7.47-7.54(5H,m),7.59(lH,m),7.70(l H,m),7.97(lH,m). IR(CHC13):3380,3260,3020,2946,2868,1708,1466,1388,1328,1149/cm. [a]D=+32.9〇 (CHC13,c=1.07,22t：). (請先閱讀背面之注意事項再本頁) 訂 經濟部中央標準局員工消費合作社印製
No.l a - 1 8 2 CDC13 300MHz 0.94.1.90(14H,m),2.25(2H,t,J=7.5Hz),2.30(lH,m),2.98(lH,m),3.70(3H(s),4.83( 1H,d, J=6.GHz),5.13-5.16(2H,m),6.95( lH,d,J=1.5Hz),7.11-7.23(2H,m),7.43(1H, d,J=8.lHz),7.65(lH,d,J=8.lHz),7.79.7.93(4H,m),9.08(lH,br). IR(CHC13):3458,3372,3020,3002,2946,2868,17 19,1598,14 52, U22,132 1,1300,1 157/cm. 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 152 513422 A7 B7 五、發明説明（) [a]D=-6.6〇 (CHC13,c=1.00), mpl50-15lt： No.l a - 1 8 3 CDC13 300MHz O.95-1.94(14H,m)，2.26(lH,m),2.28〈2H,t，J=7.5Hz),3.00(lH，m)，5.16-5.19(2H，m)， 5.32(lH,d,J=7.2Hz),6.93(lH,<l,J=1.2Hz),7.13(lH,m),7.22(lH,dd,J=7.8>6.6Hz), 7.42(lH,d,J=7.8Hz),7.63(lH,d,J=7.8Hz),7.76(2H,d,J=8.4Hz),7.90(2H,d,J=8.4H z),S.95(lH,br). IR(CHC13):3458,3374,3260,3020,3002,2948,2868,1708,1598,1452,1422,130 1,1156/cm. [a]D=+17.9〇 (CHC13，c=1.01，22t：)· No.l a - 1 8 4 CDC13 200MHz 0.92-2.00(14H,m),2.20(lH,m),2.34(2H,t,J=6.8Hz)i3.05(lH,m),5.20-5.36(3H,m), 7.39-7.44(2H,m),7.61-7.66(lH,m),7.S0-7.84(lH,m),8.05(2H,d,J=8.6Hz),S.40(2 H,d,J=S.6Hz). IR(CHC13):3384,3271,3019,2958,1709,1615,1599,1551,1453,1405,1344,1326,1 243,1163/cm. [a]D=+18.5〇 (CHC13,C=L00,2lt：). (請先閱讀背面之注意事項再 裝- 頁) 訂 線 經濟部中央標準局員工消費合作社印製
No.l a — 1 8 5 ’ CDC13 300MHz 0.89-2.20(15H,m),2.26(2H,d.t,J=2.1and7.2Hz),2.99(lH,m),5.08(lH,d,J = 6.3Hz), 5.09-5.24(2H，m)，6.90(lH，d，J=1.2Hz)，7.32-7.48(4H,m)，7.64-7.72(3H，m)，8.20(l H,d,J=1.2Hz)>9.00(lH,s). IR(CHC13):3464,3375,2275,3022,2956,1707,1005,1490,1449,1356,1322,12 19,1 147,113 1/cm. [a]D=+21.6。（CHC13.01.01，23Χ：). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 153 A7 五 、發明説明（ Β7 150
No.l a ~ 1 8 6 CDC13:300MHz 1.36.2.24(14H,m),2.31(2H,t,J=7.4Hz),2.49(lH,bs)f3.37(lH>m),3.67(3H,s),5.3S- 5.50(2H,m),7.40-7.68(9H,m). IR(CHC13):3375,1727,1602,1435,1362,1221,1207,1168,1045/cm.
No.l a - 1 8 7 CDC13：300MHz 1.10-2.25(14H，m)，2.36(2H,t,J=7.2Hz),2.47(lH，m)，3.37(lH，m)，5.3H54(2H，m), 5.62(lH,d,J=7.2Hz),7.39-7.70(9H,in). IR(CHC13):3674,3496,3376,3234,3012,2952,2880,2650，n25(sh)，1709，1602，14 85,1420,1360,1167/cm.
[a]D=+32。（CHC13,c=1.69)·
No· 1 a - 1 8 8 CDC13 200MHz 0.86-L92(14H,m)，2.22(3H，m)，2.36(3H，s)，2.95(lH，m)，3.67(3H，s)，3.93(3H，s)，4.8 l(lH,d,J=6.2Hz),5.04-5.20(2H,m),7.02-7.05(2Hfm),7.31(lH,d,J=8.6H2),7.39(l H,d,J=7.8Hz),7.79-7.89(3H,m). IR(CHC13):3385,3286,3029,3019,3015,2954,2877,1718,1617,1598,1567,1507,1 311,1269,1153 /cm.
[ajD= ·29.4。（CHC13，c=1.01，25t：)·
No. 1 a ~ 1 8 9 [a]D=-7.7a (CHC13,c=1.00,24t：).
No. 1 ci — 1 9 0 [a]D=-17.3。（CHC13.C=l.〇〇,2‘H)- 本纸張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） (請也閱讀背*面之注意事項再β 經濟部中央標準局員工消費合作社印製
-154 513422 A7 B7 五、發明説明（151 經濟部中央標準局員工消費合作社印製 Νο·1 a — 1 9 1 CDC13 300MHz 0.95-2.20(14H,m),2.30(lH，m)，2.36(2H，d，J=6.9Hz)，3.21(lH,m),4.25(2H，s)，5.07( lH,d,J=7.8Hz),5.35-5.48(2H,m),7.25(lH,dd,J=1.8 and 8.1Hz),7.32-7.35(2H,m ),7.59(lH,d,J=8.1Hz),7.94(lH,s),8.14(lH,d,J=2.7Hz),8.23(lH,d.d,J=2.7and8.7 Hz). IR(CHC13):3386,3026,3015,2957,2877,2633,1702,1617,1573,1530,1348,1123 / cm. [a]D= ·6·Γ (CHC13，c=1.01,25t：)· No.l a - 1 9 2 CDC13 300MHz 0.92.2.20(14H,m),2.13(3H,m),3.23(lH,m),3.64(3H,s),3.94(3H,s),4.22(2H,s),4.3 6(lH,d,J=7.8Hz),5.37-5.42(2H,m),7.16-7.42(6H,m),7.53(lH,d,J=8.4Hz),7.94(l H,s). IR(CHC13):3389,3022,3013,2953,2877,1716,1616,1560,1485,1340,1326,1124 / cm. [ck】D= -15.20 (CHC13,c=1.01,25t：)e No.l a - 1 9 3 CDC13 300MHz 0.92-2.20(14H，m)，2.25(lH，m),2.35(2H,t，J=7.2Hz)，3.17(lH，m)，4.22(2H，s)，4.91( lH，d，J=7.5Hz)，5.37-5.42(2H，m),7.13-7.43(6H，m)，7.60(lH，d，J=8.1Hz)，8.05(lH， s). IR(CHC13):3511,3387,3029,3020,3011,2957,2877,2651,1698,1614,1560,1505,1 320,1280,1252,1126 /cm. [a]D= ·0.9〇 (CHC13，c=1.00,25t：)e 批衣-- ·*· (請先閱讀背面之注意事項再本頁) 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 155 - 513422 A7 B7 五、發明説明（152
No.lb— 1 CDC13 300MHz 0.98-1.56(15H,m),1.85-1.9O(5H,m),2.23(lH,m),3.05(lH,m),3.66(3H,s),4.77(lH, d,J=6.0Hz),5.08-5.28(2Hlm),7.46(3H,m),7.38.7.54(2H,d,J=7.5Hz),7.72(2H,d,J= 8.4Hz),7.93(2H,d,J=8.4Hz). IR(CHC13):3384,3028,2952,2876,1719,1595,1391,1322,1155/cm.
[a ]436 +4.0^+6.0(011013,〇=1.00,23*0). mp.96-98t：
No.lb-2 ODC13 300MHz 0.98-1.52(15H,m),1.85.1.90(5H,m),2.17(lH,m),3.00(lH,m),3.67(3H,s),4.05(2H, s),4.83(lH,d,J=6.0H2),5.05-5.23(2H,m),7.14(2H,d,J=7.2Hz),7.17-7.32(5H,m),7. 78(2H,d,J=8.4H2). IR(CHC13):3384,3026,2952,2874,1719,1595,1453,1407,1320,1180/cm. [a：}D=+2.5a (CHC13，c=1.02,24t：).
No. lb — 3 CDC13 300iMHz 0.96·2.05(20Η，ιη)，2.07(1Η，πι)，3·07(ΐΗ，ιη),4.04(2Η，3)，5.21·5.35(2Η，ιη)，5.55(ΐΗ， drJ=6.9Hz)f7.14(2H>d>J=6.6Hz),7.20-7.32(5H,ra),7.78(2H,d,J=8.lH). IR(CHC13):3250,3022,2950,1699,1596,1495,1453,1405,1318,1153/cm. 經濟部中央標準局員工消費合作社印裝 [Q^D= +17.Γ (CHC13，C=l.〇l，25t：). mp.129-131t：.
No. lb — 4 CDC13 200MHz 0.90.2.L0(15H,m)tI.L9(3H,s)t1.20(3Hfs),3.il(lH,m),5.24-5.32(2H,m),5.70(lHt d,J-6.6Hz),7.38*7.68(4H,m),7.96-8.04(2H,m),8.53(lH,d,J=i.4H2). 156 本纸張尺度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） 513422 A7 B7 五
發明説明（1W 經濟部中央標準局員工消費合作社印製 IR(CHC13):3384,3246,2958,1701,1632,1595,1468,1445,1322,1216,1202,1190,1 155,1122/cm. [a]D=+10.8° (σΗ013,0=0.51,23Χ：). No.lb — 5 1.02-2.10(15H,m),1.16(6H,s),3.02(lH,m),4.09(3H,s),5.23-5.28(2H,m),5.76(lH, d,J=7.2Hz),7.36-7.63(4H,m),7.97(lH,d,J=7.8Hz),8.16(lH,s). IR(CHC13):3369,2959,1702,1635,1585,1468,1454,1441,1415,1318,1222,1189,1 170,1154/cm. [a]D=+9.9° (011(:13,0=1.00,23^). No.lc— 1 CDC13 300MHz 1.10- 2.02(14H,m),2.27(2H,t,J=7.5Hz),2.50(lH,m),2.89(3H,s),3.31(lH,m),3.64( 3H,s),5.16-5.30(2H,m),7.34-7.42(3H,m),7.50-7.59(2H,m)f7.62-7.68(2H,m),7.76-7.82(2H,m). IR(CHC13):3020,2946,2868,2212,1727,1596,1495,1437,1339,1156,1135,1084 / cm. [a 】D=-16.1° (01^13,0=1.05,25.0=). m.p.100-102t： No.lc — 2 CDC13 300MHz 1.10- 2.05(14H,m)，2.23(2H，t，J=7.5Hz),2.53(lH，m)，2.91(3H，s),3.35(lH，m),3.62( 3H,s),5.02-5.30(2Hfm),7.50-7.60(3H,m),7.90.8.08(6Htm). IR(CHC13):3〇 16,2946,2868,1728,1437,1398,1340,1160,1086 /cm. [a]D=-32.5° (ΟΗ013,〇=1.00,25.0^：). No. lc — 3 (請先閱讀背面之注^^事項再本貢) -裝·
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 157 513422 A7 B7 五、發明説明（154) CD30D 300MHz 1.15.2.05(14H，m)，2.13(2H，t，J=7.2Hz)，2.47(lH，m)，2.91(3H，s)，3.27(lH，m)，4.90· 5.30(2Η,πι),7.37.7.44(3Η,ιη),7.53-7.61(2Η,ιη),7.71-7.77(2Η,ιη),7.81-7.87(2Η,ιη ). IR(KBr):3412,2999,2951,2871,2217,1560,1399,1243,1159,1137,1103,1084. [qj]D=-8.6° (CH3OH,c=1.03,23t：).
No· Id — 1 CDC13 300MHz l. 00-2.16(15H,m),2.36(2H,t,J=7.2Hz),3.17(lH,m),3.33(3H,s),5.23.5.43(3H,m), 7.δ1-7.δ9(3Η,ιη),7.91.8.10(6Η,ιη),9.02(ΐΗ^Γ8). IR(CHC13):3382,3268,3028,2954,2874,1715,1442,1400,1337,1162,1120,1089/c m.
[a]D=+40.0° (CHC13,O0.53,22t：)·
No.ld- 2 CDC13 300MHz 1.03-2.30(17H，m),3.03(lH，m)，4.03(2H,s)，5.26(2H，m)，5.84(lH,br)，5.25-5.29(lH, d,J=6.6Hz)，6.03(lH,br),7.14(2H,d, J=8.lHz), 7.26-7.3 l(5H，m)，7.80(2H,d，J=S.l Hz). IR(CHC13):3376,3002,2946,1669,1595,1492,1454,1406,1318,1154/cm. [a]D=+4.3〇 (CHC13,c=1.00,23t：). 經濟部中央標準局員工消費合作社印製 (請先閱讀背面之注意事項再本頁)
No.ld-3 CDC13 300MHz 0.96-2.17(17H,m),2.33(2H,t,J=6.9Hz),3.01(lH,m),4.04(2H,s),5.10(lH.d,J=G.6H z)>5.21.5.26(2H,m)f7.14(2H,dIJ=8.7Hz),7.16-7.32(5H,m),7.78(2H,d,J=8.4Hz). IR(CHC13):3260,3020,2946,1711,159G,1492,1457,H07,L3 18, U54/cm. [a]D=+9.3° (CHC13,c=1.09,25t：). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 158 513422 A7 B7 155 五、發明説明
No.Id — 4 CDC13 300MHz 0.95-2.14(15H,m),2.34(2H,t,J=7.2Hz),3.09(lH,m),3.30(3H,s),4.04(2H,s),5.19(l H,d,J=7.2Hz),5.22.5.39(2H,m),7.10-7.35(7H,m),7.81(2H,d,J=8.lHz),9.10(lH,b rs). IR(CHC13):3382,3260,3028,2952,2874,2670,1713,1595,1492,1450,1405,1338,1 160,1120,1092/cm.
[o:】D=+22.2。（CHC13，C=1.07,22t：).
No. Id ~ 5 CDC13 300MHz 1.00-2.10(14H，m)，2.30-2.39(3H，m)，3.15(lH，m),3.35(3H，s)，5.18-5.40(3H，m)，7.4
l(lH,d.t.,J=0.9and7.8Hz),7.50.7.69(3H,m),7.88-8.15(2H,m),8.60(lH,d,J=1.5H z),9.06(lH,s). IR(CHC13):3382,3268,3028,2954,2874,1714,1442,1402,1338,1188,1155,1 121,1072/cm.
[a]D=+15.3° (CHC13，C=1.00,22X：)· !
No. le — 1 CDC13 300MHz 1.19-2.45(19H,m),2.58(lH,m)I5.63(lH,d,J=3.0Hz),7.42-7.65(4Hlm),7.94-8.03(2 H，m)，8.49-8.50(lH，m). 經濟部中央標準局員工消費合作社印製 IR(CHC13):3293,3024,1710,1595,1584,1467,1445, H 10,1324,1222,12 13,1206,1 190,1160/cm.
[a]D=-41.1° (CHCi3,C=1.01,23r).
No. le - 2 CDCI3 300iMHz 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 159 513422 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明（156 ) 1.10-2.25(19H,m)，2.94(lH，m)，4.12<3H，s),5.53(lH,d，J=7.2Hz)，7.39(lH，m),7.50· 7.62(3H,m),7.96(lH,d,J=7.5Hz)fS.13(lH,s). IR(CHC13):3367,3025,2955,1711,1634,1600,1584,1468,1454,1440,1415,1342,1 317,1222,1189,1157/cm. [a]D=+1.2° (CHC13,C=1.00,25t：). No.lf - 1 CDC13 300MHz ^ 1.08- 2.47(19H,m),2.56(lH,m),3.52(2H,t,J=6.6Hz),5.59(lH,d,J=2.4H2),7.40.7.6 6(4H,m),7.95-8.04(2H,m),8.50(lH,d,J=1.8Hz). IR(CHC13):3624,3383,3295,2950,2877,1705,1595,1584,1468,1445,1405,1347,1 337,1324,1224,1190,1160/cm. ; [a]D=-54.1〇 (CHC13，C=1.01，23t：). No.lf— 2 CDC13 300MHz 1.08- 2.24(19H，m)，2.94(lH，m)，3.53(2H，t，J=6.3Hz),4.13(3H，s),5.47(lH，d，J=6.6H z),7.36-7.63(4H,m),7.96(lHld,J=6.3Hz)f8.14(lH,s). IR(CHC13):3625,3368,3025,3013,2949,2877,1710,1634,1600,1584,1468,1454,1 440,1415,1342,1317,1232,1220,1189,1157/cm. [a]D=-5.6° (CHC13,C=1.00,25t：). No. lg — 1 CDC13 200MHz 1.17.2.34(15H,m)t3.22(lHfm),5.10.5.16(2H,m),5.45(lH,d,J=7.0Hz),7.35-7.66(4 H,m),7.95-8.01(2HIm),8.51(lHld,J=2.0Hz). IR(CHC13):3383,3275,2959f 1707,1595,1584,1468,1445,1425,1319,1269,1248,1 ; 190,1 149,1123/cm. MD=+64.3。（CHC13，C=1.〇l，23t：). (請先閲讀背面之注意事項再^一^本百〇 裝·
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 160 513422 A7 B7 五、發明説明（157 ) 經濟部中央標準局員工消費合作社印製
No.lg- 2 CDC13 300MHz 1.10-2.15(13H，m)，2.36(2H，t，J=7.2Hz)，3.21(lH，m),4.09(3H，s)，5.10-5.22(2H，m), ' 5.43(lH,d,J=7.8Hz),7.36.7.62(4H,m),7.96(lH,d,J=7.8Hz),S.12(lH,s). | ! IR(CHC13):3366,2959,1708,1635,1600,1585,1467,1454,1440,1415,1345,1318,1 | 233,1189,1152/cm. [a]D=+103.1° (CHC13,C=1.01,23t：). No.lh— 1 CDC13 300MHz 0.90-1.60(17H,m),1.83(lH,m),2.11(lH,m),2.22(2H,t,J=7.2Hz),3.07(lH,m),5.11( lH,d,J=7.2Hz)>7.38-7.47(lHIm),7.50-7.60(lH,m),7.60-7.72(2H,m),7.88-8.12(2 H,m),8.54(lH,d,J=0.9Hz). IR(CHC13):3382,3274,2926>1707,1464,1442,1318,1266,1188,1153f1121,1105,l 071,1019/cm. ί [a]D=-2.8。（CHC13,C=1.01，23r). j No.li- 1 [a]365 +50.9〇 (CHC13，c=1.01，24t：). ； No.li- 2 CDC13 300MHz 0.98-1.70(llH,m),1.80-2.O0(5H,m),2.19(lH,m),3.03(lH,m),3.64(2H,t,J=6.6Hz), 4.05(2H,s),4.69(lH,d,J=6.6Hz)l5.15(lH,m),5.25(lH,m),7.16(2H>d,J=7.2Hz)(7.2 :， 7-7.32(5H，m),7.77(2H，d，J=8.4Hz). IR(CHC13):3376,3004,2946,2316,1596,1492,1453,1407,13 18,1 154/cm. +3.5° (CHC13，c=1.00,22t：). mp .80.5*82.0^3 I , —- I .......- Hi -·- ii 1—！ ........................ 1-1- ϋ (請先閲讀背面之注意事項再尽頁) -11 綉 本纸張尺度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） 161 513422 A7 B7 五、發明説明（158 )
No.lj - 1 [a】436=-7.5±0.5.(CHC13，c=1.05,22t：)·
No.lj— 2 [a]D==-9.7±0.5.(CHC13，c=1.06,22t：).
No.lj - 3 [or 】D==+15.0土 0.5 (0113011,0=1.06,24.51 )·
mp. 101- lOS'C
No.lj — 4 -- [a ]D==-28.0 土0.6 (011(313,0=1.06,241). mp. 159-16 l'C lj-δ
[a]D==-l2.5±0.5.(CHC13，c=1.04,23t：)· mp.99-10 lC
No.lj — 6 CDC13 300MHz 0.90-2.03(14H,m),2.20(lH，m),2.30(2H，t，J=7.3Hz),3.00(lH，m)3.68(3H，s)，4.76(l H,dlJ=6.8Hz),5.13.5.35(2H,m),7.01-7.08(4H,m),7.19-7.26(lH,m),7.37.7.46(2H, 經濟部中央標準局員工消費合作社印製 m),7.80-7.84(2H,m). IR(CHC13):3382,3280,3080>3016,2952,2900,1727,1582, I486,1432,1322,1150/c m.
[a]D= -31.0。（CHC13,0=1.05,261).
No. lj 一 ’ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 162 513422 A7 B7 五、發明説明（159 ) 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 0.91-2.09(14H,m),2.15(lH,m),2.35(2H,t,J=7.5Hz)>3.01(lH,m),5.17(lH,d,J=6.8 Hz),5.21-5.34(2H,m),7.01.7.08(4H,m),7.15-7.27(lH,m),7.37-7.43(2H,m),7.80.7. 85(2H,m). IR(CHC13):3474,3386,3270,3024,2958,2900,2675,1711,1584,1488,1420,1323,1 | 298,1150/cm. [a】D= -13.4。（CHC13，c=1.01，26t：)· No.lj — S CDC13 300MHz 〇.95.2.14(13H，m),2.30(2H,t，J=7.5Hz)，2.36(lH，m)，2.S4(lH，m)，2.91(lJ=4.8Hz), 3.66(3H,s),5.33-5.52(2H,m),6.82.6.87(lH,m),6.93-7.00(2H,m),7.09-7.15(4H,m), 7.2S-7.36(2H,m),7.54.7.59(lH,m). IR(CHC13):3350,3010,2950,2880,172S, 1603,15S2,14S9 1461,1438,1360,1160/c m. [α]Ώ= +75.1° (CHC13,c=L13,26t：). No.lj-9 CDC13 300MHz 0.95-2.03(14H,m)f2.20(lH,m)f2.29(2H,tfJ=7.5Hz),3.06(lH,m),3.68(3H,s),4.98( lH，d,J=7.4Hz)，5.14·5.34(2H, m)，7.46-7.54(2H，m)，7.60-7.68(lH，m), 7.75-7.80(2 H，m)，7.88-7.92(2H，m)，7.99-8.03(2H，m)· IR(CHC13):3384,3280,3020,2960,2888,1727,1662,1600,1316,1273,1163/cm. [ajD= ·41.0〇 (CHC13，c=1.17,26t：). No.lj - 10 CDC13 + CD30D 300MHz 0.94-2.08(14H,m),2.21(lH,m),2.34(2Hlt,J=6.2Hz),3.0-t(LH,m).5.2i-5.35(2H,m),' 5·40(ΐΗ,ηι)·7·49·7.53(2Η,πι)·7.64.7.68(ΐΗ,πι)，7.79.8.06(6Η，Γη). (請先閱讀背面之注意事項再頁) vs -口 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 163 1J422 A7 B7 五 、發明説明（16〇) IR(CHC13):3475,3370,3250,3018,2956,2976,2650,1709,1662,1595,1445,1420, 1395,1317,1274,1163/cm. [a]D= -17.1° (CHC13,c=1.13,25t：). No.lj-11 CDC13 3Ό0ΜΗζ 1.06-1.98(14H,m),2.24-2.29(3H,m),3.13(lH,m),3.66(3H,s),5.10-5.24(2H,m),5.4 0(1H, d, J=6.3Hz)，7.39·7·49(3Ή, m), 7.59-7.64(3H，m)，7.80-7.83(2H，m), 8.08-8.11( lH,m). IR(CHC13):3302,3012,2948,2905,1727,1661,1593,1435,1332,1312,1287,1271,1 165/cm. [a]D= +15.6。（CHC13,c=1.03,26t：).
No.lj — 1 2 CDC13 300MHz 1.0S-1.98(14H，m)，2.23(lH,m)，2.33(2H，t，J=7.5Hz)，3.16(lH，m)，5.1S-5.26(2H，m)， 5.39.5.45(lH,m),7.39-7.49(3H,m),7.60-7.64(3H,m),7.80.7.S3(2H,m),8.09-8.12( lH,m). IR(CHC13):3325,3022,2956,2872,2680,1708,1662,1603,1598,1425,1340,1316,1 288,1271,1165/cin. [a]D= +9.7e (CHC13，c:0.52,25t：). 請 閲 讀 背 面 之 注 意 事 項 再 頁 裝 線 經濟部中央標準局員工消費合作社印製
No. lj - 13 CDC13 300MHz 0.95-2.00(14H,m)l2.20(lH,m),2.27(2H,t,J=6.3Hz),3.03(lH>m),3.67(3H,s),4.99( lH,d,J=6.6Hz),5.12-5.31(2H,m),7.47-7.55(2H,m),7.6〇.7.69(2H,m), 7.76-7.81(2 H,m),7.96-8.05(lH,m),8.08.8.14(lH,m),8.27-8.28(lH,m). IR(CHC13):3674,3538,3376,3276,30 12,2948,2860,1726,1GG2,1595, U40,1335,1 317,1297,1274,1 166,1 150/cm. 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 164 513422 A7 B7 五、發明説明（161 經濟部中央標準局員工消費合作社印製 [a]D=+10.2° (CHC13,c=1.00,25t：). No.lj — 14 CDC13 300MHz 0.93-2.08(14H，m)，2.21(lH，m),2.32(2H，t，J=6.3Hz)，3.00(lH，m)，5.20-5.36(2H，m), 5.38(lH,d,J=6.2Hz),7.50-7.55(2H,m),7.63-7.71(2H,m),7.77-7.81(2H,m),7.99-8. 04(lH，m)，8.10-8.18(lH,m)，8.32-8.36(lH,m). IR(CHC13):3674,3480,3374,3258,3012,2950,2875,2650,1709,1662,1598,1418,1 335,1317,1274,1143/cm. [a]D=+61.0〇 (CHC13，c=1.19,25t：). No.lj - 15 : CDC13 300MHz 0.90-2.00(14H，m)，2· 19(lH，m)，2.30(2H，t, J=7.3Hz)，3.01(lH,m)，3.67(3H，s)，4.82( lH,d,J=6.6Hz),5.14-5.34(2H,m),7.36-7.39(3H,m),7.53-7.57(2H,m),7.62.7.66(2 H,m),7.83-7.88(2H,m). IR(CHC13):3376,3276,3010,2948,2868,2212,1727,1597,1500,1437,1325,1161/c m. [a]D=-7.2〇 (CHC13,c=1.00,26t：). No. lj — 16 CDC13 300MHz 0.93-2.03(14H,m),2.15(lHfm),2.36(2H,t,J=7.5Hz),3.05(lH,m),5.20-5.40(3H,m), 7.36-7.39(3H,m),7.55-7.66(4H,m),7.84-7.88(2H,m). IR(CHC13):3470,3376,3260,30 12,2950,2868,2675,22 12,1708,1596,1503,1416,1 396,1322,1 160. [u jD = -22.4° (CHC13，c=1.00,26t：).
No. lj ~ 17 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再 -裝 頁) 訂 線 165 513422 A7 B7 五、發明説明（162 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 1.00-1.60(9H，m)，1.79-1.89(5H，m)，2.17(lH，bs)，2.23(2H,t,J=7.2Hz)，3.03(lH，m), 5.10-5.23(2H,m),5.49(lH,d,J=6.6Hz),7.40(lH,t,J=7.4Hz),7.53(lH,t,J=7.2H2),7. 60-7.68(2H,m),7.98-8.03(2H,m),8.55(lH,d,J=1.5Hz). IR(CHC13):3516,3384,3270,2666,1708,1632,1595,1584,1467,1445,1425,1374,1 345,1321,1269,1248,1218/cm. [a]D= ·7·8 0 (CHC13,c=1.01，22r)· No. lj — 18 CDC13 300MHz 0.90-2.03(14H，m)，2.19(lH，m)，2.30(2H，t，J=7.5Hz)，3.00(lH，m)，3.67(3H，sM.80( lH,d,J=6.4Hz),5.14-5.35(2H,m),6.99-7.04(2H,m),7.16-7.22(2Hlm),7.34-7.49(4 H,m),7.57-7.61(lH,m). IR(CHC13):3376,3276,3012,2948,2875,1727,1583,1488,1471,1432,1330,1311,1 150/cm. [a]D=+54.0° (¢^013,(:=0.99,251). No.lj- 19 CDC13 300iMHz 0.91-2.09(14H,m),2.15(lH,m)，2.34(2H，t，J=7.5Hz)，3.01(lH，m)，5.16(lH，d，J=6.6 Ηζ)，5·24·5.40(2Η，ιη)，7.01·7.08(2Η，ιη)，7.15·7.25(2Η，Γη)，7.35-7.53(4Η，Γη)，7.59-7. 65(lH,m). IR(CHC13):3470?3376,3260,3012,2950,2875,2640,1708,1583,1488,147 1,1430,1 335,1305,1149/cm. [a]D= -21.0。（CHC13.c=1.30,25t：).
No.lj- 2 0 CDC13 300MHz 1.17(lH,m), 1.26-L34(2H,m),l-54-2.24(l lH,m),2.31(2H,t,J = 7.4Hz),2.48( 1 H.bs), 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再頁) 裝_
、1T 絲 166 513422 A7 B7 五、發明説明（163 3.37(lH,m)，3.67(3H，s)，5.35-5.50(2H，m)，7.39-7.68(9H,m)· IR(CHC13):3377,1727,1601,1435,1362,1168/cm.
No.lj — 2 1 CDC13 300MHz l,l〇.2.25(14H,m),2.36(2H,t,J=7.2Hz),2.47(lH,m),2.89(lH,m),5.35-5.53(2H,m)l 5.63(lH,d,J=7.2Hz),7.40-7.71(9H,m). IR(CHC13):3674,3496,3374,3234,3010,2952,2870,2640,1730(sh), 1710,1605,14 85,1425,1360,1167/cm.
[a]D=-43.0° (CHC13，c=1.01，25t：)·
No.lj — 2 2 CDC13 300MHz 0,98-1.95(14H，m),2.25-2,31(3H，m)，2.95(lH，m),5.19-5.30(2H，m)，5.33(lH，d，J=3. 9Hz),6.58(lH,d,J=7.5H2),6.80(lH,t,J=7.5Hz),6.99-7.05(lH,m),7.44-7.53(6H,m), 7.60-7.73(9H,m)f7.94-7.73(3H,m),8.23-S.26(2H,m),10.66(lH,s). IR(CHC13):3475,3372,3260,3008,2952,2868,2722,1725,1710(sh)f 1663,1590,15 7 1,1525,1448,1437,1345,1314,116 l，1112/cm.
[a]D=+12.9° (CHC13，c=0.12,23t：).
No.lj — 2 3 CDC13 300MHz 經濟部中央標準局員工消費合作社印製 0.94-1.94(14H,m),2.23-2.30(3Hfm),2.98(lH,m),3.68(3H,s),5.09{lH,d,J = 6.2Hz), 5.15-5.28(2H,m),7.14-7.22(lH,m),7.34-7.42(2H,m),7.68-7.73(2H,m),7.89-8.03( 4H,m),8.51(lH,s). IR(CHC13):3372,3275,1724,1673,1599,1438,1320,116 1/cm.
[a]D二 +17,0 〇 (CHC13.(:=1.38,251).
No. lj - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 167 513422 A7 B7 五、發明説明（164 CDC13+CD30D 300MHz 0·96·2.05(14Η,ιη),2,25-2.34(3H,m)，2.92(lH，m),5.16-5.34(2H，m),7.14-7.22(1H, m),7.29-7.42(2H,m),7.70(2H,d,J=7.6Hz),7.92-8.05(4H,m). IR(CHC13):3616,3426,3375,3010,2950,2828,2645,1708,1672,1599,1439,1323,1 161/cm.
[a]D=+21.0° (ΟΗ3ΟΗ,ο=1.00,22^).
No.lj— 2 5 CDC13 300MHz 1.03(lH，m)，1.18-2.01(13H,m)，2.20(lH,bs),2.27(2H,t,J=7.4Hz),3.08(lH,m),3.66 (3H,s)>5.11(lH,d>J=6.6Hz),5.14-5.34(2H,m),7.54-7.62(3H>m),8.04-8.32(6H,m). IR(CHC13):3384,3278,1726,1605,1484,1448,1331,1161/cm.
No.lj- 2 6 CDC13+CD30D 300MHz l,03-2.10(14H,m),2.22(lH,m).2.31(2H,t,J=7.5Hz),2.98(lH,m),5.23-5.38(2Hfm), 7.55-7.66(3H,m),8.05-8.08(2H,m)f8.14-8.18(2Hfm),8.28-8.31(2H,m). IR(Nujol):3260,2720,2660,1711,1545,1460,1317,1163/cm.
[〇f】D=+15.8e (CH3OH,c=1.01,22t：)·
No.lj - 2 7 [or]D= +16.7° (CHC13，c=1.00,23t：). 經濟部中央標準局員工消費合作社印製
No.lj- 2 8 CDC13 300MHz 1.0 l(lH，m)，1· 14· 1.29(2H，m)，1.46-2.19(1 lH，m),2.33(2H，t，J=7.2Hz)，2.41(lH，bs)， 3.18-3.21(5H，m)，3.68(3H，s)，3.73-3.76(4H，m),4.37(lH，d，J=7.2Hz)，5.35-5.45(2H， m). IR(CHC13):3392,1727,1435,1335,1148/cm. 168 本紙張又度適用中國國家標準（CNS ) A4規格（210X 297公釐） 513422 A7 B7 五、發明説明（165 [a]D= +10.7 ° (CHC13,c=1.39,26t：)·
No.lj - 2 9 CDC13 300MHz 1.00(1H,m),l.20-1.29(2H,m),l,48-2.25(12H,m),2.37(2H,t,J=7.2Hz)„3.17-3.22(5 H, m),3.74-3.79(4H,m),4.79(lH,d,J=7.8Hz),5.34-5.54(2H,m). IR(CHC13):3470,3390,3270,2675,1709,1455,1420,1315,1147/cm.
[a]D= +16.8 〇 (CHC13,c=1.42,26t：)·
No.Ik — 1 [a]D= ·25·4〇 (CHC13,c=1.08,23t：)·
No.lk- 2 CDC13 200MHz I. 07-2.28(14H,m),2.32(2H,t,J=7.4Hz),2.63(lH,m),3.63(3H,s),3.93(lH,m)>5.30-5.52(2H,m),6.35(lH,d>J=7.0Hz),7.48-7.60(3H,m),7.88-8.02(6H,m). IR(CHC13):3438,3002,2946,2868,1727,1652,1514,1485,1363,1310,1245,1154 / cm.
[a]D==-80.4° (ΟΗΟ13,ο=1.01,24.0Τ：).
No.Ik — 3 CDC13 200MHz 經濟部中央標準局員工消費合作社印製 1.10-2.26(14H,m),2.37(2H,t,J=7.2Hz)t2.60(lHfm),3.93(lH,m),5.30-5.50(2H>m), 6.33(lH,d,J=7.5Hz),7.48-7.58(3Hlm),7.88.7.99(6H,m). IR(CHC13):3446,3004,2952,2874,1709,1652,1515,1485,1305,1153 /cm.
[α ]D==-96.4。（CHC13，c=l.05,23.Ot：)·
No.lk- 4 CDC13 300MHz 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 169 2234 A7 B7 五、發明説明（166) 1.05- 2.17(14H,m),2.38(2H,t,J=7.2Hz),2.52(lH,m),3.81(lH,m),5.33-5.50(2H,m), 6.08(lH,d,J=7.6Hz),7.39-7.53(3H,m),7.57-7.62(6H,m). IR(CHC13):3420,3250,3008,2948,2870,2660,2208t1735(sh), 1705,1640,1500/cm | • i [a】D=-21.9士0.6〇 (CHC13，c=1.02,22t：)·
No.lk — 5 CDC13 300MHz 1.05- 2.14(14H,m),2.38(2H,t，J=7.2Hz)，2.51(lH,m)，3.81(lH,m),5.34-5.46(2H,m)， 6.07(lH,d,J=7.6Hz)，7.33-7.56(5H，m). IR(CHC13):3422,3250,3010,2950,2876,2664,2558,2210,1735(sh), 1705,1645,15 02,1441,1410,1307,1276/cm.
[a ]D=-63.6士 1.9。（CHC13，c=0.56,22t：)·
No.lk — 6 CDC13 300MHz 1.04.2.24(14H,m),2.36(2H,t,J=7.5Hz),2.58(lH,m),3.88(lH,m),5.30-5.43(2H,m), 6.21(lH，d，J=7.2Hz)，7.41-7.49(3H,m),7.73-7.77(2H,m)· IR(CHC13):3447,3011,2955,1708,1653,1603,1578,1515,1486,1457,1312,1211,1 164/cm.
[a]D=-60.3° (CHC13,C=1.00,23t：). 經濟部中央標準局員工消費合作社印製
No. Ik— 7 CDC13 300MHz 1.04.2.22(14HJm),2.36(2H>t,J=7.2Hz),2.57(lHfm),3.87(lH,m),5.30-5.44(2H,m)l 6.17(lHld,J=8.7Hz)>6.99-7.40(7H,m),7.73(2H,dtJ=7.5Hz). ; IR(CHC13):3449,3013,2955,1739,1708,1651,1609,1588,1522,1487,1243,1227,1 ! 169/cm.
[¢^1)=-60^((^000.92,231). 本紙張尺度適用中國國家森準（CNS ) A4規格（210X 297公釐） -170 - 513422 A7 B7 五、發明説明（167 )
No.lk — 8 CDC13 300MHz 1.04-2.25(14H,m),2.34(2H,t,J=7.5Hz),2.56(lH，m),3.87(lH,m)，5.30-5.44(2H，m), 6.19(lH,d,J=7.5Hz),6.83-6.94(6H,m),7.69(2H,d,J=8.7Hz). IR(CHC13):3599,3455,3012,2955,1711,1644,1604,1577,1524,1507,1492,1290,1 236,1197,1170/cm. [a]D=-47.7° (CHC13，C=1.01，22X：)· No.lk — 9 CDC13 300MHz L04.2.20(14H,m),2.31(3H,s),2.36(2H,t,J=7.2Hz),2.56(lH,m),3.86(lH,m),5.30-5.43(2H,m),6.16(lH,d,J=7.2Hz),7.00-7.11(6H,m),7.74(2H,d,J=8.7Hz). .IR(CHC13):3450,3010,2955,1750,1709,1651,1609,1596,1523,1489,1370,1247,1 227,1183/cm. [ct]D=-54.r (CHC13,C=L01,22t：).
No.lk — 10 CDC13 300MHz 1.04-2.22(14H，m)，2.35(2H，t,J=7.2Hz)，2.56(lH，m),3.82(3H,s),3.86(lH，m),5.30-5.43(2H,m),6.17(lH,d,J=6.9Hz),6.89-7.01(6H,m),7.70(2H,d,J=8.7Hz). IR(CHC13):3023,2955,1742,1708,1649,1613,1602,1577,1522,1507,1490,1227,1 210,1170/cm. [〇f]D=-58.r (CHC13，C=1.01,22t：)· 請 先閱 讀 背 δ之注 意 事 項再 ¥ 頁 裝 訂 線 經濟部中央標準局員工消費合作社印製
No. lm — 1 CDC13 300MHz 1.06-2.25(14H，m)，2.32(2H，t，J=7.4Hz)，2.61(lH，m)，3.63(3H，s),3.91(lH，ni)，5.33· 5.47(2H，m)，6.24(lH，d，J=6.9Hz)，7.35-7.38(3H，m)，7.53-7.60(4H,m)，7.75-7.78(2 本纸張尺度適用中國國家標隼（CNS ) A4規格（210X297公釐） 171 513422 A7 B7 五、發明説明（168 經濟部中央標準局員工消費合作社印製 H, m), IR(CHC13):3438,3008,2946,2875,2212,1732,1650,1605,1519,1496/cm. [a]D= +76° (CHC13,0=1.39,24^) No.lm — 2 CDC13 300MHz I. 05-2.20(14H,m),2.36(2H,t,J=6.2Hz),2.59(lH,m),3.89(lH,m),5.29-5.48(2H,m), 6.26(lH,d,J=7.0Hz),7.26.7.38(3H,m),7.52-7.60(4H,m),7.73-7.77(2H,m)e IR(CHC13):3444,3012,2952,2874,2664,2214,1718(sh), 1708,1649,1605,1520,14 98/cm. [a]D= +81·4β (CHC13，c=1.01，23t：) No.lm — 3 CDC13 300MHz 1.06-2.23(14H，m)，2.32(2H,t，J=7.0Hz)，2.62(lH，m),3.63(3H，s)，3.93(lH,m),5.30· 5.50(2H,m),6·28(1Η,d,J=7.0Hz)，7.38-7.51(3H, m), 7.58-7.67(4H，m), 7.83-7.88(2 H, m)〇 IR(CHC13):3438,3008,2948,2875,1783(w),1727,1650,1608,1580(w),1523,1501, 1482/cm. [a]D= +59° (CHC13,c=1.49,25t：) No.lm — 4 CDC13 300MHz I. 08-2.25(14H,m),2.36(2H,t,J=7.4Hz),2.59(lH,m)f3.91(lH,m),5.28-5.48(3H,m), 6.29(lH,d,J=7.4Hz),7.38.7.50(3H,m),7.61-7.67(4H,m),7.81-7.86(2H,m). IR(CHC13):3436,3010,2948,2868,1727,1715(sh), 1649,, 1615(w), 1524,1502,1482, 1372/cm. [〇MD= +720 (CHC13，c=0.98,25t：) (請先閱讀背面之注意事項再 •裝- 頁) 訂 線 本紙張尺度適用中國國家標準（CMS ) A4規格（210X297公釐） 172 513422 A7 B7 五、發明説明（169
No.lm — 5 CDC13 300MHz 1.09- 2.20(14H,m),2.32(2H,t,J=7.2Hz),2.63(lH,m),3.63(3H,s),3.92(lH,m),5.3l. 5.51(2H,m),6.35(lH,d,J=7.0Hz),7.51-7.60(3H,m),7.92.7.97(6H,m). IR(CHC13):3436,3008,2946,2875,1727,1652,1608(w), 1515,1484/cm.
[a]D= +82。（CHC13，c=0.99,25t：)
No.lm — 6 CDC13 300MHz 1.09- 2.23(14H，m),2.37(2H，t，J=7.2Hz)，2.60(lH,m)，3.92(lH，m)，5.30-5.49(2H，m), 6.32(lH,d,J=7.4Hz),7.51-7.55(3Hfm),7.85-7.98(6H,m). IR(CHC13):3436,3010,2950,2875,2670,1727,1715(sh),1650,1605(w), 1515,1484/ cm.
[a]D= +84° (011013^=1.54,25=)
No.lm— 7 CDC13 300MHz 1.03-2.18(14H,m),2.32(2H,t,J=7.4Hz)l2.59(lH,m),3.64(3H,s),3.89(lH,ni),5.29- 5.49(2H,m),6.16(lH>d,J=7.8Hz),6.98-7.06(4H,m)>7.14-7.20(lH,m),7.34.7.41(2 Η,Γη),7.73-7.78(2Η,ιη). IR(CHC13):3438,3008,2946t2868,1727,1648,1610,1586,1519,1485/cm.
[a】D= +54。（CHC13，c=1.29,25t：)· 經濟部中央標準局員工消費合作社印製
No.lm —8 . CDC13 300MHz 1.06.2.21(14H,m),2.36(2H,t,J=7.5Hz),2.58(lH,m),3.88(lH,m)l5.31-5.46(2Hfm), 6.17(lH,dlJ=6.9Hz)f6.99.7.05(4H,m),7.15.7*21(lH,m),7.36-7.41(2H,m),7.72-7. 75(2H,m). IR(CHC13):3436,3010,2948,2868,2675,1730(sh), 1709,1647,1608,1586,1520,14 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 173 五 、發明説明（ 170 A7 B7 85/cm.
[a】D= +56。（CHC13,c=0.97,25t：)
No.lm — 9 CDC13 300MHz 1.05-2.18(14H，m),2.29-2.34(5H,m),2.59(lH，m),3.64(3H，s)，3.89(lH，m)，5.32-5.4 6(2H,m),6.16(lH,d,J=7.5H2)(7.00-7.11(6H>m),7.74-7.77(2H,m). IR(CHC13):3440,3010,2946,2868,1729,1649,1595,1519,1488/cm.
[a】D= +47。（CHC13,c=0.82,25X：)·
No.lm— 10 CDC13 300MHz 1.04- 2.20(14H,m),2.31-2.39(5H,m),2.57(lHfm),3.87(lHfm),5.28-5.47(2H,m),6.1 7(1H,d,J=7.0Hz),6.99-7.12(6H,m),7.72.7.76(2H,m). IR(CHC13):3674,3572f3438,3010,2948f2868,2626,1748,1710,1648,1615,1595,1 520,1489/cm.
[a】D= +5Γ (CHC13，c=0.91，25t：)
No.lm— 11 CDC13 300MHz 經濟部中央標準局員工消費合作社印製 (請先閲讀背面之注意事項再頁) 1.04- 2.16(14H，m)，2.31(2H，t，J=7.2Hz),2.59(lH，m)，3.63(3H,s),3.89(lH，m)，5.29· 5.49(2Hfm),6.24(lH,d,J=7.4Hz),6.54(lH,s),6.83.6.93(6H,m),7.69.7.73(2H,m). IR(CHC13):3674,3588,3438,3296,3010,2946,2868,1725,1646,1603,1520,1504,1 489/cm.
[ajD= +51。（CHC13,c=〇.91,25t：)
No.lm- 1 2 CDC13 300MHz
1.04.2.21(14H,m),2.33(2H,t,J=8.0Hz),2.56(lH,m)>3.87(lH,m),5.28-5.48(2H,m)I 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇χ297公釐） 174 513422 A7 B7 五、發明説明（171 經濟部中央標準局員工消費合作社印製 6.23(lH,d,J=8.0Hz),6.75(lH,m),6.87-6.94(6H,m),7.66-7.71(2H,m),9.63(lH,bs). IR(CHC13):3674,3582,3436,3275,3010,2950,2868,2675,1727,1710(sh), 1643,16 03,1522,1504,1490/cm. i [a]D= +30° (CHC13，c=0.97,25t：) | No.lm — 13 CDC13 300MHz 1.01-2.18(14H,m)，2.31(2H，t，J=7.4Hz),2.58(lH,m)，3.63(3H，s),3.82(3H，s), 3.89(1 H, m),5.29-5.48(2H,m),6.14(lH,d,J=7.0Hz),6.88-7.02(6H,m),7.70-7.74(2H,m). IR(CHC13):3442,3402,3004,2946,2868,1727,1648,1600,1518,1499/cm. [ct】D=+42。（CHC13，c=1.82,26t：) No.lm — 14 CDC13 300MHz I. 05-2.21(14H,m),2.35(2H,t,J=7.2Hz),2.55(lH,m),3.82(3H,s),3.88(lH,m),5.27-5.46(2H,m)f6.16(lH,d,J=7.2Hz),6.88-7.02(6H,m),7.68-7.73(2H?m). IR(CHC13):3438,3012,2948,2870,2650,1730(sh), 1709,1647,1615(sh), 1601,1519, 1492/cm. [a]D=+64e (CHC13,c=0.70,25t：) No.lm — 15 CDC13 300MHz 1.05-2.20(14H,m),2.29-2.36(5Hfm),2.62(lH,m)>3.63(3H,s)>3.92(lH,m),5.30-5.5 0(2H,m),6.25(lH,d,J=7.2Hz),7.16-7.21(2H,m),7.59.7.64(4H,m)>7.83-7.87(2H,m )· IR(CHC13):3446f3010,2946,2868,1745(sh), 1728,1650,1615,1525,1507,1486/cm.
[a]D=+65.0〇 (CHC13,c=l.〇2,23t：) 本纸張尺度適中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再 頁) 175 513422 A7 B7 五、發明説明（172 經濟部中央標準局員工消費合作社印製
No.lm— 16 CDC13 300MHz l. 08-2.21(14H,m),2.34-2.40(5H,m)，2.59(lH，m)，3.90(lH，m),5.29-5.48(2H,m)，6.2 9(lH,d,J=7.0Hz),7.18(2H,d,J=8.6Hz),7.58-7.64(4H,m),7.83(2H,d,J=8.2Hz). IR(CHC13):3438,3012,2948,2870,2622,1749,1710,1649,1610,1526,1508,1487/c m. [o：】D=+66e (CHC13,c=1.21，24t：) No.lm — 17 CDC13 300MHz 1.06-2.19(14H，m),2.32(2H,t，J=7.2Hz),2.62(lH,m),3.63(3H,s),3.93(lH，m)，5.30· 5.50(2H,m),6.32(lH,d,J=7.6Hz),6.41(lH,s),6.94(2H,d,J=9.0Hz),7.47(2H,d,J=9. 0Hz),7.58(2H,d,J=8.6Hz),7.81(2H,d，J=8.6Hz)· IR(CHC13):3580,3434,3284,3010,2946,2868,1726,1646,1606,1528,1490/cm. [〇r]D=+62.4e (ΟΗΟ13，=1·01,23ΐ：) No. lm - 18 CDC13+CD30D 300MHz l.ll-2.18(14H，m),2.32(2H，t,J=7.4Hz)，2.59(lH,m),3.88(lH,m)，5.30-5.49(2H，m)， 6.55(lH，d,J=7.0Hz),6.92(2H,d,J=8.6Hz)，7.47(2H，d，J=8.6Hz)，7.59(2H,d，J=8.6H z)f7.79(2H,d,J=8.2Hz). IR(Nujol):3398,3175,2725,1696,1635,1601,1531,1510/cm. [ct]D=+99.5e (CH3OH,c=L011,25t：) No.lm— 19 CDC13 300MHz 1.05-2.20(14H, m)，2.32(2H, t, J=7.4Hz),2.61(iH，m), 3.63(3H，s), 3.86(3H，s), 3.94(1 H，m)，5.30-5.50(2H，m)，6.24(lH，d，J=7.0Hz)，6.99(2H，d，J=8.6Hz)，7.53-7.63(4H，m ),7.82(2H,d,J=8.6Hz). --J-------批衣一— (請先閱讀背Vg之注^一思事項再頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 176 513422 A7 B7 五、發明説明（173 經濟部中央標準局員工消費合作社印製 IR(CHC13):3440,3006,2946,2875,1726,1649,1606,1527,1510,1489/cm. [a]D=+68° (CHC13，c=0.88,26=) No.lm — 20 CDC13 300MHz 1.09-2.20(14H,m),2.35(2H,t,J=7.3Hz),2.58(lH,m),3.85(3H,s),3.89(lH,m),5.28- 5.48(2H,m),6.3D(lH,d,J=7.2Hz),6.98(2H,d,J=8.8Hz),7.51.7.61(4H,m),7-Sl(2H, d,J=8.4Hz),8.34(lH,bs). IR(CHC13):3446,3012,2952,2881,2640,1730(sh), 1707,1647,1606,1527,1510,14 89/cm. [a]D=+83e (CHC13，c=1.00,25r). No.lm— 2 1 CDC13 300MHz 1.05.2.14(14H，m)，2.37(2H，t,J=7.2Hz)，2.51(lH，m),3.81(lH，m)，5.34-5.46(2H，m)， 6.11(lH，d，J=7.5Hz)，7.33-7.48(3H，m)，7.53-7.55(2H，m). IR(CHC13):3420,3250,3008,2948,2870,2660,2210,1735(sh), 1705,1645,1503,14 41,1409/cm. [a】D=+59.2± 1.0。 （CHC13，c=1.023,22t：)· No.lm — 2 2 CDC13 300MHz 1.05-2.17(14H，m)，2.37(2H，t,J=7.2Hz)，2.52(lH，m)，3.82(lH，m),5.32-5.47(2H,m)， 6.20(lH，d，J=7.6Hz),7.38-7.53(3H,m)，7.58-7.61(6H，m)，9.11(lH，bs). IR(CHC13):3420l3250l3010,2984,2870,2675f2208f1730(sh), 1705,1640,1500,14 06/cm. [a!D=+57.4〇 (CHCl3,c=1.83,23t：). No. 1 m ~ 2 3 (請先閱讀背面之注意事項再本頁) 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 177 513422 A7 B7 五、發明説明（174 CDC13 300MHz 1.05-2.18(14H，m)，2.31<2H,t，J=7.5Hz)，2.60(lH，m)，3.63(3H,s)，3.90(lH，m),5.32· 5.47(2H，m)，6.22(lH,d,J=6.9Hz),7.40-7.49(3H，m),7.76-7.79(2H,m). IR(CHC13):3438,3008,2946,2868,1727,1651,1603,15S5,1512,1484/cm. [a】D=+52〇 (CHC13，c=1.49,25t：)· No.lm— 2 4 CDC13 300MHz 1.05.2.21(14H,m),2.36(2H,t,J=7.2Hz),2.57(lH,m),3.S9(lH>m),5.2S-5.47(2H,m), 6.22(lH,d,J=7.0Hz),7.39-7.55(3H,m),7.73-7.79(2H,m). IR(CHC13):3676,3572,3436,3010,2948,2875,1730(sh), 1709,1650,1600,1580,15 14,1484/cm. : [a]D=+57° (CHC13,c=0.97,26t：)· No.lm— 2 δ CDC13 300MHz 1.04-2.1S(14H,m),2.28-2.35(5H,m),2.59(lH,m),3.62(3H,s),3.88(lH?m),5.29-5.4 9(2H,m),6.20(lH,d,J=7.2Hz),7.15(2H,d,J=9.0Hz),7.S0(2H,d,J=8.8Hz). IR(CHC13):3436,3010,2946,2868,1752,1727,1653,1602,15 19,1491/cm. [a]D=+53° (CHC13，c=1.63,25r). (請先閱讀背面之注意事項再 -裝- 頁)
、1T 線 經濟部中央標準局員工消費合作社印製
No.lm - 2 6 CDC13 300MHz 1.05-2.19(14H，m)，2.32.2.38(5H，m)，2.56(lH，m)，3.88(lH，m)，5.29-5.47(2H，m)，6.2 5(lH,d,J=7.4Hz),7.15(2Hld,J=9.0Hz),7.78(2H,d,J=8.6Hz). IR(ChTCi3):3434,3016,3006,2948,2880,2622,1752,1730(sh), 17 10,1651,1G05.15 20,1492/cm. (a]D=+58° (CHCl3,c=3.68,24t：) 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 178 5 2 42 3 ) Μ Β7 五、發明説明（175) 經濟部中央標準局員工消費合作社印製
No.lm— 2 7 CDC13 300MHz 1.05- 2.16(14H，m),2.30(2H，t，J=7.5Hz)，2.57(lH，m)，3.62(3H，s)，3.87(lH,m)，5.27·丨 5.47(2H,m),6.32(lH,d,J=7.4Hz),6.85(2H,d,J=8.6Hz),7.62(2H,d,J=8.6Hz),8.35( ! lH，s). IR(CHC13):3580,3450,3216,3010,2946,2868,1726,1640,1608,1584,1528,1496/0 m. [a]D=+56.2° (CHC13，c=0.713,23t：) No.lm— 2 8 CDC13 200MHz 1.10-2.25(14H,m),2.32(2H,t,J=7.2Hz),2.55(lH,bs),3.82.3.93(lH,m),5.27-5.47(2 H,m),6.25(lH,d,J=7.4Hz),6.86(2H,d,J=8.6Hz),7.62(2Hfd,J=S.6Hz). IR(CHC13):3438,3242,2675,1730(sh)，1708,1639,1607,1585/cm. No.lm— 2 9 CDC13 300MHz 1.05- 2.18(14H，m)，2.31(2H，t，J=7.4Hz)，2.58(lH,m)，3.64(3H，s)，3.85(3H,s)，3.89(1 H，m)，5.29-5.48(2H,m)，6.14(lH，d，J=6.6Hz)，6.92(2H，d，J=9.0Hz)，7.74(2H，d,J=9· 0Hz). IR(CHC13):3445,3008,2946,2868,1727,1646,1606,1578,1523,1493/cm. [o:]D=+53〇 (CHC13，c=2.03,24t：)
No. 1 m — 30 CDC13 300MHz 1.04-2.21(14Η,Γη),2.36(2Η,1,α=7.3Ηζ),2.δ6(ΐΗ,πι),,3.8δ(3Η,5),3.88(ΐΗ,πι),5.27-5.46(2H,m),6.15(lH,d,J=7.2Hz)l6.92(2H,d,J=8.6Hz),7.73(2H,d,J=8.6Hz). IR(CHCl3):3440,3010,2950,2870,2645f1727f ni0(sh),1646,1606,1575,1524, U 94/cm. 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再 -裝- 頁) 訂 線 179 513422 A7 B7 五、發明説明（176) 經濟部中央標準局員工消費合作社印製 [a]D=+62° ((:11013^=1.10,241). No.lm— 31 CDC13+CD30D 300MHz 1.16-2.20(14H,m),2.31(2H，t,J=7.2Hz),2.59(lH，m)，3.85(lH,m)，5.31-5.51(2H,m)， 7.13- 7.21(lH，m),7.31-7.42(2H,m)，7.68-7.93(6H,m). IR(Nujol):3344,3175,2715,2675,1699,1631,1566/cm. [a]D=+67° (CH3OH，c=1.01，24t：)· No.lm- 3 2 CDC13 200MHz 1.09-2.23(14H，m)，2.33(2H，t,J=7.1Hz),2.57(m,bs)，3.40-3.93(9H,m)，4.41(lH,bs), 5.29.5.48(2H,m),6.44(lH,d,J=7.4Hz),7.43(2H,d,J=8.2Hz),7.80(2H,d,J=7.8Hz). IR(CHC13):3434,3354,1726,1720(sh),1660(sh),1626/cm. No.lm — 33 CDC13 200MHz 1.14- 2.25(14H，m),2.37(2H，t,J=7.3Hz)，2.64(lH，bs)，3.93-4.01(lH,m)，5.30-5.51(2 H,m),6.47(lH,d,J=7.4Hz),7.63-7.74(2H，m),7.79(2H，s),7.89-7.93(lH,m)，8.00(lH, dd,J=2.3,1.0Hz),8.30(lH,d,J=1.0Hz),8.65-8.73(2H,m). IR(CHC13):3450,2675,1728,1707,1649,1528,1509/cm. [a 】D=+82.8± L2。（(^0)13^=1.01,23=). No.2a-l
No.2a-2 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.15 and 1.24(each 3H,each s), 1.50-2.50(14H,m),4.30(1 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） ---：---r-----裝-- (請先閱讀背面之注意事項再本頁) 訂 線 180 513422 A7 B7 五、發明説明（177 ) H,m),5.35-5.52(2H,m),6.32(lH,dfJ=8.7Hz),7.36.7.49(3H,m),7.58-7.62(2H,m),7. 66 and 7.80(each 2H,each d,J=8.7Hz). , IR(CHC13):3116,3014,2925,2870,2663,1708,1651,1610,1524,1504,1484,1472 / cm.
[a]D= +64.Γ (MeOH,c=1.02,25t：).
No.2a-3 [a]D=+76.6°
No.2a-4 CDC13 300MHz 0.99(lH,d,J=10.2Hz), 1.15 and 1.25(each 3H,each s),1.64-2.51(14H,m),4.31(1 H,m),5.36-5.53(2H,m),6.33(lH,d,J=8.4z),7.50-7.56(3H,m),7.85-7.98(6H,m). IR(CHC13):3515,3452,3014,2925,2870,1740,1708,1654,1517, I486,1470 /cm. [a]D= +79.5。（MeOH,c=1.18, 22t：)·
No.2a-5 CD30D 300MHz 經濟部中央標準局員工消費合作社印製 0.98(1H,d，J=9.9Hz), 1.18 and 1.25(each 3H,each s)，1.56-1.71(3H,m),1.98-2.4 0(llH,m),4.17(lH,m),5.41-5.52(2H,m)>7.52.7.61(3H>m)f7.91-8.01(6H,ra). IR(KBr):3416,3063,2983,2921,2869,1704,1643,1566,1518,1488,1408 /cm. [o:]D= +62·0β (MeOH,c=1.00, 25t：).
No.2a-6 [a]D=+64.1° (MeOH,c=1.01,25t：).
No.2a-7 [a jD=+65.3e (1^011/=0.99,25=). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 181 513422 A7 B7 五、發明説明（178 經濟部中央標準局員工消費合作社印製
No.2a.8 [a】D=+74.0〇 (MeOH,c=1.01，25t：). No.2a-9 [a]D=+71.〇° (MeOH,c=1.10,25t：)· No.2a-10 [a]D=+74.7° (MeOH,c=1.00,25t：). No.2a-ll [ck]D=+72.1〇 (MeOH，c=1.00,25t：)· No.2a-12 [a]D二+53.10 (CHC13，c=1.01，26t：)· m.p.155.0-156.Ot： No.2a-13 CDC13 300MHz 0.98(lH，d，J=10.2Hz)，1.18 and 1.25<each 3H，each s)，l.63-2.40(14H，m)，4.30(1 H,ra),5.46.5.58(2H,m),6.44(lH,dfJ=8.4Hz)；7.49 and 7.77(each 2H,each d,J=8. 7Hz),7.54(lH,s). IR(CHC13):3689,3378,3028,3014,2924,1713,1652,1602,1522,1496 /cm. [a]D= +78.3° (MeOH,c=0.84,25t：). m.p.205.0-206.Ot： No.2a-14 [a lD=+72.5° (MeOH,(:=1.07,251).
No.2a-15 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再^^4頁) -絮· 、^ 線 182 513422 A7 B7 五、發明説明（179 CDC13 300MHz 0.99(lH,d,J=9.9Hz),1.14 and 1.24(each 3H,each s), 1.55-2.44(14H,m),4.27(1 H，m)，5.30-5.50(2H,m)，6.29(lH，d,J=9.0Hz),7.11 and 7.20(each 1H,each d，J=l 6.2Hz),7.29-7.55(5H,m),7.57 and 7.72(each 2H,each d,J=8.7Hz). IR(CHC13):3453,3083,3022,3013,2925,2870,1708,1650,1607,1560,1522,1496 / cm.
[a]D= +72.3° (MeOH,c=1.00,27t：). m.p.ll5.0-117.0t：
No.2a-16 CDC13 300MHz 0.92(lH，d,J=10.2Hz),l.ll and 1.23(each 3H,each s),1.50-2.48(14H,m),3.62(3 H,s),4·29(1Η,m),5·30·5,50(2Η,m),6.20(lH,d,J=8.7Hz),6.59 and 6.68(each 1H， each,d,J=12.3Hz),7.23(5H,s),7.29 and 7.59(each 2H,each d,J=8.1Hz). IR(CHC13):3453,3024,3016,2924,2870,1730,1651,1607,1520,1495 /cm.
[a]D= +56.8° (MeOH,c=1.04,24t：)·
No.2a-17 CDC13 300MHz 0.97(lH，d,J=10.2Hz),1.11 and 1.23(each 3H,each s),1.50-2.38(14H，m),4.26(1 H,m),5.30-5.50(2H,m)f6.23(lH,d,J=8.4Hz),6.59 and 6.70(each lH,each d,J=l 2.3Hz),7.23(5H,s),7.30 and 7.57(each 2H,each d,J=8.7Hz). 經濟部中央標準局員工消費合作社印製 IR(CHC13):3452,3081,3019,3014,2925,2870,2665,1708,1650,1607,1521,1495 / cm.
[c〇D= +61.6。（MeOH,c=1.00,27t：)·
No.2a-15 CDC13 300MHz 0.97(lHfd,J = 10.2Hz), 1.11 and 1.23(each 3H,each,s), 1.50-2.50(14H,m),3.61(3 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 183 513422 A7 B7 五、發明説明（180 經濟部中央標準局員工消費合作社印製 H,s),4.31(lH,m),5.35-5.51(2H,m),6.33(lH,d,J=8.4Hz),7.48-7.64(4H,m),7.79-7. 83(2H,m),7.91(lH,dt,J=1.5 and 7.8Hz),8.01(lH,dt，J=1.5 and 7.8Ηζ),8·13(1Η， t,J=1.5Hz). IR(CHC13):3450,3026,3013,2925,2870,1730,1659,1600,1510 /cm. [a]D= +56.0° (MeOH,c=1.01，25t：). No.2a-19 CDC13 300MHz 〇.95(lH，d,J=9.9Hz),1.14 and 1.21(each 3H,each s)，1.53-2.60(14H，m),4.25(1 Hfm),5.35-5.64(2H,m),7.21(lH,d,J=7.8Hz)l7.49-7.68(4H,m),7.76-7.84(3H,m),8. 25(lH,m),8.43(lH,m). IR(CHC13):3382,3196,3025,3015,2925,2870,1725,1652,1599,1577,1521 /cm· [a]D= +55.9。（MeOH,c=1.00,25t：)·, No.2a-20 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.13 and 1.24(each 3H,each s), 1.50-2.50(14H,m),3.62(3 H,s),4.31(lH,m),5.35-5.51(2H,m),6.24(lH,d,J=8.4Hz),7.40-7.52(3H,m),7.71-7. 76(2H,m). IR(CHC13):3453,3025,3013f2925,2870,1730,1753,1579,1514,1486 /cm. No.2a-21 CDC13 300MHz 0.98(lH，d,J=l〇.2Hz), 1.13 and 1.23(each 3H,each s),1.52-2.50(14H，m),4.28(1 H，m)，5.34-5.51(2H,m),6.27(lH,d，J=8.7Hz)，7.41-7.53(3H,m),7.71-7.74(2H，m). IR(CHC13):3452,3063,3027,3014,2925,2871,1708,1652,1578,1515,1486 /cm. [a】D= +62.0。（MeOH，c=1.01，27t：)· 本紙展尺度適用中國國家標準（CNS ) Μ規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) -裝· 線 184 513422 A7 B7 五、發明説明（181 經濟部中央標準局員工消費合作社印製
No.2a-22 d6-DMS0 300MHz 〇.86(lH,d,J=9.9Hz),l.lO and 1.16<each 3H,each s),1.42-1.52(3H,m),1.85-2.4 6(llH,m),3.9S(lH,m),5.32-5.43(2H,m),7.41(3H,m),7.88(2H,d,J=6.6Hz),8.19(l H,d,J=€.6Hz). IR(KBr):3367,3060,2984,2922,2868,1634,1563,1529,1487/cm. [a]D=+47.7° (MeOH,c=l.QO,25t：). No.2a-23 [a】D=+62.7e (MeOH,c=1.01,27t：)· No.2a-24 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.14 and 1.25(each 3H,each s), 1.52-2.50(14H,m),4.31(1 H,m),5.36-5.52(2H,m),6.34(lH,d,J=8.4Hz)>7.47-7.52(2H,m)>7.59.7.64(lH>m),7. 78-7.83(6H,m). IR(CHC13):3449,3027,3013,2925,2869,1708,1656,1599,1518,1493 /cm. [a]D= +63.1° (MeOH,c=1.00,25t：). No.2a-25 [a]D=+35.1e (MeOH，c=1.00,25t：). No.2a-26 [a]D=+35.5° (MeOH，c=1.02,25t：). No.2a-27 CDC13 300MHz 0.97(lH,d,J=10.2Hz),1.12 and 1.23(each 3H,each s), 1.52-2.50( 14H,m),3.63(3 H,s),4.29(lH,m)f5.36-5.51(2H,m),6.18(lH,d,J=8.4Hz),7.01 and 7.7i(each 2H, (請先閱讀背面之注意事項再本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 185 J^422 經濟部中央標準局員工消費合作社印製 A7 B7 i、發明説明（182) each d,J=8.7Hz,)f6.98-7.05<2H,m)>7.16(lH,t,J=7.5Hz),7.34-7.41(2H,in). IR(CHC13):3455,3024,3016,2924,2870,1730,1651,1588,1520,1487 /cm. [a】D=+56.4* (MeOH,c=1.01，25t：)·
No.2a-28 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.12 and 1.23(each 3H,each s), 1.52-2.50(14H,m),4.26(l H,m),5.34-5.51(2H,m),6.20(lH,d,J=9.0Hz),7.01 and 7.70(each 2H,each d,J=9. 0Hz,),6.98-7.15(2H,m),7.17(lHft,J=7.5Hz),7.34-7.40(2H,m). IR(CHC13):3454,3031,3018,2925,2870,1708,1650,1588,1523,1487/cm. {a]D= +56.2。（MeOH，c=1.00,25t：).
No.2a.29 [a]D=+53.0° (Me〇H,c=1.03,25t：).
No.2a-30 CDC13 300MHz 0.97(lH，d，J=10.2Hz)，1.10 and 1.23(each 3H，each s)，l.52.2.50(14H，m)，4.25(1 H，m),5.30.5.50(2H,m)，6.23(lH，d，J=8.7Hz)，6.36(lH，s)，7.26-7.39(10H，m)，7.60 a nd 7.68(each 2H,each d,J=8.4Hz,). IR(CHC13):3451,3088,3064,3029,3014,2925,2869,1707,1652,1522,1495 /cm. [a]D=+54.2° (MeOH，c=1.00,25t：).
No.2a-31 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.14 and 1.24(each 3H,each s), 1.50-2.50( 14H,m),3.63(3 H,s),4.31(lH,m),5.30.5.50(2H,m)I6.26(lH,d,J=8.4Hz),6.90(lH,t,J = 7.4Hz),7.13( lH,d,J=8.7Hz),7.29(2H,t,J=8.0Hz)t7.67-7.75(5H,m),7.32(lH,s). IR(Nujol):3380,3244,1723,1638,1601,1578,1535,1495 /cm. 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再B本頁) 、v5 186 513422 A7 B7 五、發明説明（183) 經濟部中央標準局員工消費合作社印製 [a]D=+73.6〇 (MeOH,c=0.50,26t：). 111^.133.0-134.0^ No.2a-32 [立】D=+56.1° (MeOH，c=1.02,26t). No.2a-33 CDC13 300MHz 0.95(lH,d,J=10.2Hz),l.l〇 and 1.21(each,3H,each s), 1.50-2.50(14H,m),4.25(1 H,m),5.13(2H,s),5.30-5.70(3H,m),6.41(lH,d,J=8.2Hz),6.89(lHfs),7.09(lH,s)f7. 17 and 7.72(each 2H,each d,J=8.2Hz),7.62(lH,s). IR(CHC13):3450,3125,3031,3013,2925,2870,2467,1917,1708,1654,1615,1575,1 523,1497 /cm. [a]D=+55.2〇 (MeOH,c=1.01,26t：). No.2a-34 [a]D=+72.9〇 (MeOH,c=1.03,25t：). No.2a-35 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.13 and 1.24(each 3H,each s), 1.52-2.48(14H,m)f4.28(1 Hfm),5.35-5.51(2H,m),6.28(lH,d,J=8.7Hz),7.34.7.37(3H,m),7.52-7.55(2H,m),7. 58 and 7.71(each 2H,each d,J=8.7Hz). IR(CHCi3):3515,3452,3030,3012,2925,2870,1739,1708,1652,1607,1555,1521,1 497 /cm. [Q：jD=+74.3〇 (MeOH,c=1.01，25t：). No.2a-36 [a !D=+23.4e (Me〇H,c=1.07,25t：). (請先閱讀背面之注意事項再本頁) -裝· 訂 線 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） 187 I5 423 A7B7 五、發明説明（184) 經濟部中央標準局員工消費合作社印製
No.2a-37 CDC13 300MHz 0.83(lH，d,J=10.5Hz),0.95 and 1.18(each 3H，each s),1.44-2.46(14H，m),3.92(1 H,m),5.34-5.52(3H,m),7.26-7.54(9Hfm),7.62(lH,s). IR(CHC13):3432,3310,3189,3023,3014,2924,2870,1704,1610,1594,1523,1487 / cm. [a]D=+25.3° (ΜβΟΗ/=1·00,26^：). No.2a-38 [a]D=+70.9e (MeOH，c=1.02,25t：)· No.2a-39 [a】D=+70.6° (ΜβΟΗ，=1·01，25Χ：)· No.2a-40 [a]D=+74.7° (MeOH,c=1.00,25t：)· No.2a-41 [〇;】D=+72.r (MeOH，c=1.01,24C). No.2a-42 [a】D=+69.2〇 (MeOH,c=1.00,25t：)· No.2a-43 [a】D=+70.8° (MeOH,c=1.00,25t：)· No.2a-44 [a]D=+60.4° (MeOH,c=U)0,26t：). (請先閲讀背面之注意事項再本頁) -裝· 、訂 線 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ 297公釐） 188 513422 A7 B7 五、發明説明（185) 經濟部中央標準局員工消費合作社印製
No.2a-45 CDC13 300MHz 〇.97(lH,d,J=9.9Hz),1.13 and 1.23{each 3H,each s)，1.55-2.52(14H，m),4.29(1 H，m),5.34-5.54(2H,m)，6.33(lH,d，J=9.0Hz),7.10(lH，t，J=7.4Hz)，7.34(2H,t，J=7.4 Hz),7.52(2H,m),7.68 and 7.75(each 2H,each d,J=S.4Hz),7.S0(lH,s),8.10(lH,s )，10.09(lH，s)· IR(CHC13):3393,3195,3093,3033,3013,2925,2870,1698,1656,159S, 1537,1498 / cm. [a]D=+59.4e (MeOH，c=1.01，24t：). No.2a-46 : [a]D=+63.5° (MeOH，c=1.00,25t：). No.2a-47 CDC13 300MHz 0.97(lH,d,J=9.9Hz),1.12 and 1.23(each 3H,each s), 1.54-2.4S(14H,m),4.29(l H，m)，5.35-5.52(2H,m),6.32(lH，d，J=3.7Hz)，7.26(lH，m)，7.41(2H，t,J=7.8Hz)，7.6 4(2H,d，J=7.5Hz),7.73 and 7.77(each 2H，each d，J=S.4Hz)，7.95(lH，s)，9.20(lH， s)，10.38(lH,s)· IR(CHC13):3450,3339,3003,2992>2925,2870f 1706,1653,1596,1523,1495/cm. [〇r】D=+63.3〇 (MeOH，c=l.00,25T：). No.2a-48 [a]D=+63.8〇 (ΜβΟΗ,ο=1.00,24Χ：). No.2a.‘19 CDC13 300MHz 1.00( 1 H,d,J= 10.5Hz), 1.17 and 1.26(each 3H,each s), 1.55-2.52( l4H,m),4.34( 1 (請先閱讀背面之注意事項再本頁) •裝. 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 189 513422 A7 B7 五、發明説明（186 ) H,m)，5.36-5.54(2H，m)，6.35(lH，d，J=9.0Hz)，7.50-7.62(3H,m)，7.90 and 8.33(eac h 2H,each d,J=8.4Hz),8.21(2Hfm). IR<CHC13):3451,3029,3022,3016,2925,2870,1708,1655,1542,1508,1498,1471,1 459 /cm.
[a】D=+63.5〇 (MeOH,c二 1.02,25t：). m.p.135.0-137.Ot：
No.2a-50 [a]D=+68.9e (MeOH，c=1.01，24t：).
No.2a-51 d6-DMSO 300MHz : 0.87(lH,d,J=9.9Hz),1.10 and 1.17(each 3H,each s), 1.40-1.60(3H,m), 1.90-2.4 0(11H,m),3.98(lH,m),5.35-5.46(2H,m),7.64(lH,s),7.65 and 7.91(each 2H,eac h d,J=8.7Hz),8.06(lH,d,J=6.0Hz),9.32<lH,bs). IR(KBr):3385,2962,1734,1707,1632,1529,1498 /cm.
[o:]D=+68.4e (MeOH，c=l,01，24t：).
No.2a-52 [a]D=+76.2〇 (MeOH,c=1.01,24t：).
No.2a-53 經濟部中央標準局員工消費合作社印製 (請先閱讀背面之注意事項再本頁) [ajD=+73.9° (MeOH，c=1.02,24t：).
No.2a-54 .
[a]D=+G8.1° (MeOH，c=1.00,24t：).
No/2a-55 [ajD = + G7.8° (MeOH,c=1.00,m). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 190 513422 A7 B7 五、發明説明（187 ) 經濟部中央標準局員工消費合作社印製
No.2a-56 [a]D=+65.4° (MeOH,c=1.03,25^C). No.2a-57 [a]D=+63.4〇 (MeOH,c=1.01,24t：). No.2a-58 [a]D=+66.6° (MeOH，c=1.01，24t：). No.2a*59[a ]D=+65.5〇 (MeOHpl.OOjW). No.2a-60 [a]D=+60.9° (MeOH,c=1.02,25t：)· No.2a-61 CDC13 300MHz 0.97(lH,d,J=10.0Hz),1.10 and 1.22(each 3H,each s), 1.50-2.50(14H,m),4.26(1 H?m),5.30-5.54(2H>m),6.28(lH,d,J=S.6Hz),6.60 and 6.82(each lH,each d,J=l 2.4Hz,),7.12(2H,d,J=6.0Hz),7.25 and 7.62(each 2H,each dfJ=8.6Hz),8.47(2H, d,J=6.0Hz).IR(CHC13):3452,3027,3019,3013,2925,2870,2480,1708,1651,1606,1520,1494 / cm. [a]D=+61.6° (MeOH,c=1.01，25t：). No.2a-62 [a ]D=十72.0〇 (MeOH.c^O.iKUSC). ^---.-----裝--(請先閱讀背面之注-ή思事項再本百〇 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 191 513422 A7 B7 五、發明説明（188 ) 經濟部中央標準局員工消費合作社印製
No.2a-63 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.14 and 1.24(each 3H,each s), 1.50-2.50(14H,m),4.29(1 H,m),5.36-5.55(2H,m),6.35(lH>d,J=9.1Hz),7.04 and 7.27(each lH,each d,J=l 6.5Hz),7.37(2H,d,J=6.6Hz),7.56 and 7.76(each 2H,each d,J=8.4Hz),8.57(2H, d,J=6.6Hz). IR(CHC13):3452,3024,3018,3014,2925,2870,2470,1933,1708,1652,1605,1521,1 496 /cm. [a]D=+69.2〇 (MeOH,c=1.01,25t：). No.2a-64 [a]D=+56.9° (MeOH，c=1.24,25t：). No.2a-65 CDC13 300MHz 0.9S(lH,d,J=10.5Hz), 1.12 and 1.23(each 3H,each s), 1.54-2.46(14H,m),4.27(1 H,m),5.23(2H,s),5.34-5.52(2H,m),6.26(lH,d,J=8.4Hz),7.32.7.45(5H>m),7.64 an d 7.71(each 2H,each d,J=8.4Hz),8.15(lH,s). IR(CHC13):3452,3088,3065,3032,3013,2925,2870,1708,1653,1611,1559,1522,1 496 /cm. [ci]D=+61·。。(MeOH，c=0.91，25t：). No.2a-66 [a]D=+76.0〇 (iMeOH,c=1.01,25t：). No.2a-67 CDC13 300MHz 0.98(lH,d,J=10.4Hz), 1.14 and 1.24(each 3H,each s)f 1.54-2.4.28( 1 H,m),5.32-5.53(2H,m),6.27(lH,d,J=8.6Hz),6(92-7.31(each lH.each d,J=16.4H (請先閱讀背面之注意事項再本頁) 本紙張尺度適用中國國家標準（CNS ) A4現格（210X 297公釐） 192 513422 A7 B7 五、發明説明（ z),7.02(lH,dd,J=5.S and 3.6Hz),7.12(lH,d,J=3.6Hz),7.24<lH,d,J=5.8Hz),7.51 and 7.70(each 2H,each d,J=8.4Hz). IR(CHC13):3453,3029,3013,2925,2870,1739,1650,1604,1524,1515,1494 /cm. [a]D=+76.2〇 (MeOH,c=1.00,24t：). m.p. 104.0-106.0^3
No.2a-68 [a]D=+57.7〇 (MeOH,c=1.01,25t：).
No.2a-69 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.14 and 1.24<each 3H,each s), 1.54-2.4S(14H>m),4.28(1 H,m),5.34-5.53(2H,m),6.29(lH,d,J=9.t)Hz),6,54-6.74(each lH,each d,J=12.0H z),7.02(lH,dd,J=4.8 and 3.3Hz),6.97(lH,dd,J=3.3 and 1.2Hz),7.13(lH,dd,J= 4.8 and 1.2Hz),7.44 and 7.70(each 2H,each d,J=8.7Hz). IR(CHC13):3453,3025,3010,2925,2870,1708,1650,1607,1559,1523,1493 /cm. [a]D=+58.4。（MeOH，c=1.00,25t：).
No.2a-70 [cr]D=+48.6° (MeOH,c=1.00,25t：). 經濟部中央標準局員工消費合作社印製
No.2a-71 CDC13 300MHz
0.98(lH,d,J=10.2Hz),1.12 and 1.23(each 3H,each s), 1.52-2.46(14H,m),2.31(3 H,s),4.26(lH,m),5.33-5.52(2H,m),6.20(lHId,J=9.3Hz),7.02-7.11(6H,m),7.70(2H d,J=9.0Hz). IR(CHC13):3460,3031,3022,30 11,2925,2870,1750,1708,1650,1608,1597,1523,1 490 /cm.
[a (MeOH，c=l.01,25^：). 193 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 513422 A7 B7 五、發明説明（190 經濟部中央標準局員工消費合作社印製
No.2a-72 [a]D=+51.2° (MeOH,c=1.02,25t：). No.2a-73 CDC13 300MHz 〇.97(lH,d,J=9.9Hz),l.ll and 1.23(each 3H,each s), 1.54-2.48(14H,m),4.27(1 H,m),5.32.5.52(2H,m),6.24(lH,d,J=9.0Hz),6.83-6.94(6H,m),7.65(2H,d,J=9.0Hz ). IR(CHC13):3598,3451,3199,3033,3012,2925,2870,1708,1642,1604,1524,1507,1 491 /cm. [a]D=+52.2° (MeOH,c=1.01,25t：). No.2a-74 [a]D=+51.5e (MeOH,c=0.92,25t：). No.2a-75 CDC13 300MHz 0.97(lH,d,J=10.2Hz),l.ll and 1.23<each 3H,each s), 1.55-2.46(14H,m),3.82(3 H,s),4.25(lHIm),5.32.5.52(2H,m),6.19(lHidfJ=8.7Hz),6.89-7.01(6H,m),7.65-7. 68(2H,m). IR(CHC13):3450,3025,3008,2925,2870,2837,1741,1649,1612,152 1,1505,1490 1 cm. [a]D=+51.1° (MeOH，c=1.00,25t：). No.2a-76 [a]D=+G0.4〇 (MeOH，c二0.98,251). J
No.2a-77 本紙張尺度適用中國國家標率（CNS )八4規格（210X 297公釐） (請先閱讀背面之注意事項再本頁) -裝· 訂 線 194 513422 A7 B7 五、發明説明（191 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 〇.99(lH,d,J=10.5Hz),1.15 and 1.24(each 3H,each s), 1.54-2.48(14H,m),2.34(3 H,s),4.29(lH,m),5.32-5.54(2H,m),6.32(lH,d,J=8.4Hz),7.19 and 7.60<each 2H, each d,J=8.4Hz),7.63 and 7.79(each 2H,each d,J=S.4Hz). IR(CHC13):3452,3027,3012,2925,2870,1751,1709,1651,1611,1560,1527,1509,1 489 /cm. [a]D=+61.2° (MeOH,c=1.00,25t：). No.2a-78 [a]D=+67.4° (MeOH,c=1.01，25t：)· No.2a-79 CDC13 300MHz ’ 0.99(lH,d,J=10.2Hz),1.15 and 1.24(each 3H,each s), 1.54-2.54(14H,m),4.31(1 H,m),5.32-5.54(2H,m),6.36(lH,d,J=8.2Hz),6.93 and 7.48(each,2H.each d,J=8. 6Hz),7.59 and 7.75(each 2H,each d,J=8.4Hz). IR(CHC13):3593,3448,3192,3030,3010,2925,2870,1708,1644,1608,1591,1559,1 530,1516,1491 /cm. [a]D=+65.8° (MeOH，c二 1.01，25t：)· No.2a*80 [a]D=+66.9° (MeOH，c=1.01，25t：).
No.2a-81 CDC13 300MHz 0.99(lH,dtJ=10.5Hz),1.15 and 1.24(each 3H,each s), 1.54-2.48( 14H,m),3.80(3 H,s),4.29(lH,m),5.34-5.52(2H,m)f6.20(lH,d,J=8.7Hz),6.99 and 7.55(each 2H, each d,J=9.0Hz),7.61 and 7.77(each 2H,each d,J=S.7Hz). IR(CHC13):3450,3009,2925,2870,2838,1740,1708,1650,1608,1557,1528,15 12, L 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再本頁) 铸 195 513422 A7 B7 五、發明説明（192 經濟部中央標準局員工消費合作社印製 491 /cm. [a】D=+66.2° (MeOH，c=1.01，25t：). No.2a-82 [a】D=+57.7〇 (MeOH，c=1.02,24^C). No.2a-83 CDC13 300MHz 〇.97(lH,d，J=10.2Hz)，1.12 and 1.23(each 3H，each s)，1.54-2.48(14H，m)，2.33(3 H,s),4.26(lH,m),5.32.5.52(2H,m),6.25(lH,d,J=8.7Hz),7.16 and 7.75(each 2H, each d,J=8.7Hz). IR(CHC13):3452,3030,3022,3012,2925,2870,1754,1709,1654,1604,1585,1522,1 493 /cm. [a]D=+57.4° (MeOH，c=1.01，24t：). No.2a-84 [a]D=+57.8° (MeOH，c=1.01，24t：). No.2a-85 CDC13 300MHz 〇.95(lH,dfJ=10.2Hz),1.12 and 1.22(each 3H,each s), 1.54-2.48(14H,m),4.25(1 H，m)，5.32-5.52(2H，m)，6.28(lH，d，J=S.7Hz)，6.87 and 7.57(each 2H，each d，J二9. 0Hz). IR(CHC13):3590,3450,3166,3019,3012,2925,287 1,1708,1637,1608,1583,1531,1 498 /cm. [c〇D=+56.0° (MeOH,c=1.01，24t：)· No.2a-86 [a!D=+59.3〇 (MeOH,c=l.01,22t：). (請先閲讀背面之注意事項再頁)
、T 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 196 513422 A7 B7 五、發明説明（193
No.2a-87 CDC13 300MHz 0.9S(lH，d，J=10.0Hz),1.13 and 1.23(each 3H,each s),1.54-2.48(14H，m)，3.85(3 H，s)，4.25(lH，m),5.32-5.53(2H,m)，6.19(lH，d，J=8.8Hz)，6.93 and 7.69(each 2H, each d,J=9.0Hz). IR(CHC13):3450,3030,3017,3012,2925,2870,2840,1740,1708,1647,1606,1575,1 525,1496 /cm.
[a]D=+58.2〇 (MeOH,c=0.99,22t：).
No.2a-88 [a]D=+50.9° (i\IeOH,c=1.02,25eC).
No.2a-S9 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.18 and 1.26(each 3H,each s), 1.56*2.48(14H,m),4.29(1 H,m),5.36-5.54(2H,m),7.03(lH,d,J=8.7Hz),7.21(lH,s),7.43(2H,m),7.74(lH,ddd, J=1.8,6.9 and 8.7Hz),8.22(lH,dd,J=1.8 and 8.1Hz). IR(CHC13):3443,3087,3023,3014,2925,2870,1708,1685,1658,1630,1517,1466 / cm.
[a]D=+57.1〇 (MeOH，c=lX)l，22t：). m.p.117.0-118.Ot： 經濟部中央標準局員工消費合作社印製
No.2a-90 [a]D=+54.1〇 (MeOH，c=1.01，22t：).
No.2a-91 CDC13 300MHz 0.97(lH,d,J=10.2Hz),L13 and 1.23(each 3H,each s), 1.52-2.46( 14H,m),4.24( 1 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 197 513422 A7 B7 五、發明説明（194 H，m)，5.34-5.52(2H，m)，6.49-6.53(2H，m),7.11(lH，dd，J=0.9 and 3.6Ηζ)，7·44(ΐΗ， dd，J=0.9 and 1·8Ηζ). IR<CHC13):3437,3033,3022,3014/2925,2870,1739,1/708,1655,1595,1520,1472 / cm. 經濟部中央標準局員工消費合作社印製 [a]D=+55.0° (MeOH,c=1.00,22t：). No.2a-92 [a]D=+50.3° (MeOH，c=1.0O,22t：). No.2a-93 CDC13 300MHz 0.95(lH,d,J=10.5Hz),1.12 and 1.23{each; 3H,each s), 1.52-2.46(14H,m),4.25(1 H,m),5.34-5.52(2H,m),6.12(lH,d>J=8.7Hz),7.07(lHldd,J=3.9 and 5.lHz),7.45-7.48(2H,m). IH(CHC13):3450,3023,3011,2925,2870,1739,1708,1645,1531,1501,1471 /cm. [a]D=+49.1° (MeOH,c=1.02,24t：)· No.2a-94 [a】D=+51.5〇 (MeOH，c=1.00,24t：). No.2a-95 CDC13 300MHz 0.96(lH,d,J=10.5Hz),l.ll and 1.23(each 3H,each s), 1.δ2-2.46(14Η,ιη),4.2δ(1H,m),5.34.5.56(2H,m),6.14(lH,d,J=8.7Hz),7.34(2H,d,J=2.0Hz),7.85(lH,tfJ=2.0 Hz). IR(CHC13):3452,3 114,3030,3013 2925,2870,1708,1649,1535,1498,147 1 /cm. [a ]D=+55.5〇 (MeOH，c= 1.00,251). m.p.87.0-88.0t： (請先閲讀背面之注意事項再本頁) -裝· 訂 線 本纸張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 198 513422 A7 B7 五、發明説明（195
No.2a-96 CD30D 300MHz 〇.94(lH,d,J=10.2Hz),1.13 and 1.22<each 3Hfeach s), 1.50-1.76(3H,m), 1.94-2. 39(llH,m),4.11(lH,m),5.39.5.49(2H,m),7.43-7.51(2H,m),8.05(lH,m). IR(KBr):3369,30S4,2985,2921,2868,1630,1566,1538,1503 /cm. [a]D=+38.8〇 (MeOH,c=1.01,22t：). No.2a-97 CD30D 300MHz0.93(lH,d，J=9.9Hz),1.13 and 1.22(each 3H,each s),1.48-1.5S(3H，m),1.96-2.3 6(llH,m),4.10(lH,m),5.35.5.50{2H>m),7.42.7.51(2H,m),8.06(lH>m). IR(KBr):3447,3087,2987,2922,2868,1629,1545,1501 /cm. [or]D=+52.9e (MeOH,c=1.01,24t：).
No.2a-9S [a]D=+53.2° (MeOH,c=1.02,23t：)· 請 閱 讀 背 5 意 事 項 再 頁 玎 經濟部中央標準局員工消費合作社印製
No.2a-99 CDC13 300MHz〇.97(lH，cl，J=10.2Hz)，1.12 and 1.22(each 3H,each s)，1.26-2.45(24H，m)，4.25(2 H，m)，5.34-5.52(2H，m)，6.18(lH，d,J=8.7Hz),6.91 and 7.66(each 2H，each d，J=9· 0Hz). IR(CHC13):3455,3029,3019,2939,2862,1738,1709,1645,1605,1523,1494 /cm. [a]D=+51.4° (MeOH，c=l.00,23t：). No.2a-100 [a]D=+49.3〇 (MeOH,c=1.00f24<t：).
No.2a-101 本紙張尺度適用中國國家標準（CNS ) A4規格（2!〇χ 297公釐） 199 513422 A7 B7 五、發明説明（1% ) 經濟部中央標準局員工消費合作社印製 [a】D=+51.3e (MeOH,c=1.00,24t：)· No.2a-102 [a]D=+48.8e (MeOH,c=1.01,23t：). No.2a-103 CDC13 300MHz 0.94(lH,d,J=10.2Hz),1.12 and 1.22(each 3H,each s),1.52-2.46(14H,m),2.48(3 H,d,J=0.3Hz),4.20(lH,m)f5.32-5.54(2H,m),6.46(lH,bs),7.12(lH,d,J=9.0Hz). IR(CHC13):3415,3144,3029,3011,2926,2871,1708,1671,1598,1538,14564 /cm. [a】D=+49.6° No.2a-104 [a]D=+77.0e (MeOH，c=1.02,23t：)· No.2a-105 CDC13 300MHz 0.93(lH,d,J=9.9Hz),1.09 and 1.21(each 3H,each s), 1.51-2.44(14H,m),3.90(6 H,s),4.20(lH,m),5.38.5.50(2H,m),5,87(lH,d,J=9.0Hz),6.25 and 7.54(each 1H, each d,J=15.6Hz),6.84(lH,d,J=8.lH2),7.03(lH,d,J=1.8Hz),7.09(lH,dd,J=1.8 a nd 8.1Hz). IR(CHC13):3439,3028,3012,2937,2871,2841,1739,1708,1661,1620,1600,1513 / cm. [a]D=+77.3e (MeOH，c=1.01，23t：)· No.2a-106 [a 】D=+67.0。（MeOH,c=1.00,25r). No.2a-107 (請先閱讀背面之注意事項再 -裝· 頁) 訂 線 本紙浪尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 200 513422 A7 B7 五、發明説明（197) 經濟部中央標準局員工消費合作社印製
[a]D=+66.6° (MeOH,c=1.01,24t：). m.p.l68.〇.170.0t： No.2a-108 [a]D=+61.8e (M^OH,c=LOO,22t：). No.2a-109 CDC13 300MHz 0.96(lH,d,J=10.2Hz),1.10 and 1.22(each 3H,each s), 1.5l-2.45(14H,m),4.25(l H,m),5.33-5.49(2H,m),6.2l(lH,d,J=8.7Hz),7.25 and 7.60(each 2H,each d,J=8. 7Hz),7.33-7.41(5H,s). IR(CHC13):3453,3062,3028,3014,2925,2870,1739,1708,1651，1594,1557,1515,1 481 /cm. [a]D=+61.0° (MeOH,c=1.01,22t：). No.2a.110 CD30D 300MHz 0.94(1H,d，J=9.9Hz), 1.13 and 1.22(each 3H,each s)，1.54-2.37(14H，m),4.12(1 H,m),5.38-5.49(2H,m),7.25 and 7.68(each 2H,each d,J=8.7Hz),7.4l(5H,s). IR(KBr):3435f3058,2986,2920,2866,1635,1595,1562,1521,1482,1439,1411 /cm [〇f]D=+47.3° (MeOHfc=1.01,23t：). No.2a-lll (a]D=+65.6° (MeOH>c=1.01,24<C). No.2a-112 CDC13 300MHz 0.97(lH,d,J=10.2Hz), 1.12 and 1.23(each 3H,each s), L5 l-2.46(14H,m),4.27(I (請先閱讀背面之注意事項再頁) 、v'iv 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 201 513422 A7 B7 五、發明説明（198 經濟部中央標準局員工消費合作社印製 H,m),5.35.5.50(2H,m),6.22(lH,d,J=8.4Hz),7.40 and 7.66<each 2H,each d,J=9. OHz). IR(CHC13):3439,3028,3012,2937,2871,2841,1739,1708,1661,1620,1600,1513 / cm. [a]D=+65.6〇 (MeOH,c=1.01,22t：). No.2a-113 {a]D=+59.6° (ΜθΟΗ,ο=1.00,24^：). · No.2a-114 CDC13 300MHz 0.98(lH，d，J=10.2Hz), 1.12 and 1.24(each 3H，each s),1.52-2.46(14H,m)，4.29(1 H,m),5.35-5.51(2H,m),6.28(lH,d,J=8.4Hz),7.70 and 7.83(each 2H,each d,J=S. 4Hz). IR(CHC13):3439,3028,3012,2937,2871,2841,1739,1708,1661,1620,1600,1513 / cm. [a]D=+60.6。（MeOH,c=1.01，22t：). No.2a-115 [a]D=+59.7° (MeOH,c=0.99,24t：). No.2a-116 CDC13 300MHz 0.97(lH,d,J=10.2Hz),1.12 and 1.23(each 3H,each s), 1.52-2.46( 14H,m),2.39(3 H,s)r4.27(lH,m),5.33-5.51(2H,m),6.24(lH,d,J=9.0Hz),7.23 and 7.62(each 2H, each d，J=8.4Hz). IR(CHC13):3439,3028,3012,2937,287 1,284 1,1739,1708,166 1,1620,1600,15 13/c m. (a]D=+59.7〇 (MeOH,c=0.99,24t：). (請先閱讀背面之注意事項再頁) -裝·
、1T 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 202 513422 A7 B7 五 、發明説明（199
No.2a-117 [a]D=+56.7e (MeOH,c=1.00,23t：)· No.2a-118 CDC13 300MHz 0.96(lH,d,J=10.2Hz),l.ll and 1.23(each 3H,each s),1.53-2.44(14H,m),4.23(1 H,m),5.34-5.51(2H,m),6.02(2H,s),6.13(lH,d,J=8.7H2),6.83(lH,dd,J=1.2 and 7. 8Hz),7.22-7.25(2H,m). IR(CHC13):3453,3031,3020,3012,2924,2870,1740,1708,1650,1619,1605,1519,1 504,1480 /cm. [a ]D=+57.2e (1^011^=1.02,231). No.2a-119 CDC13 300MHz 0.96(lH,d,J=10.5Hz),1.07 and 1.23(each 3H,each s),1.51-2.44(14H，m),2.32(3 H,s)，4.26(lH，m),5.37-5.52(2H，m)，6.40(lH，d，J=9.0Hz),7.09(lH，m),7.30(lH，m), 7.46(lH,m),7.66(lH,m). IR(CHC13):3443,3028,3012,2925,2870,1766,1747,1709,1657,1607,1516,1479 / cm. [a ]D=+53.2。 (請先閲讀背面之注意事項再—本頁) -裝· 訂 線 經濟部中央標準局員工消費合作社印製
No.2a-I20 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.14 and 1.24(each 3H,each s)，1.53-2.44(14H,m),4.30(1 H,m)l5.35-5.52(2H>m),6.42(lH,d,J=8.7Hz),6.85(lH,m),6.99(lH,dd,J=1.2 and 8.4Hz),7.27(lH，m),7.39(lH，m). IR(CHC13):3463,3033,3021，3014,2992,2924,2870，1708，1643,1597，1523，1488 / cm. 本纸張又度適用中國國家標準（CNS ) A4規格（210X 297公釐） 203 513422 A7 B7 五、發明説明（ 200 [a]D=+46.3〇 (MeOH,c=1.01,21t：). No.2a-121 CDC13 300MHz Ό·98(1Η,d,J=10.2Hz),1.14 and 1.23(each 3H,each s)，1.47-2.47(14H,m),3.95(3 H,s),4.31(lH,m),5.32.5.50(2H,in),6.98(lH,dd,J=0.9 and 8.4Hz),7.09(lH,ddd,J =0.9,7.7 and 8.4Hz),7.45(lH,m),8.19(lH,dd,J=2.1 and 8.lHz),8.32(lH,d,J=9. OHz). IR(CHC13):3400,3078,3028,3020,3007,2924,2870,2842,1736,170s, 1640,1600,1 536,1483,1470 /cm. [a]D=+38.1〇 (MeOH,c=1.02,23t：). No.2a-122 [a]D=+42.3〇 (MeOH,c=0.99,23t：). No.2a-123 [a]D=+38.7° (MeOH，c=1.00,2lt：). No.2a-124 [a]D=+45.03 (MeOH,c=1.01,2lt：). m.p.ll9.0-120.0t： No.2a-125 [ajD=+49.8° (MeOH，c=1.01,22t：)· —^---^-----裝-- (請先閱讀背面之注意事項再本頁) 訂 線 經濟部中央標準局員工消費合作社印製
No.2a-126 CDC13 300MHz 0.97(lH,d,J=10.2Hz), 1.11 and 1.23(each 3H,each s)f I.52-2.47(14H,m),4.2G(l H,m),5.34.5.50(2H,m),6.22{lHfd,J=8.7Hz),7.55-7.61(4H,m). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 204 一 ο n - 513422 A7 B7 五、發明説明（201 ) IR(CHC13):3400,3078,3028,3020,3007,2924,2870,2842,1736,1708,1640,1600,1 536,1483,1470 /cm.
[a]D=+63.0〇 (MeOH,0=1.01,23^).
No.2a-127 CDC13 300MHz 0.91(lH,d,J=10.2Hz), 1.10 and 1.20(each 3H,each s), 1.50-2.42(14H,m),4.23(1 H,m),5.31<5.51(2H,m),6.45(lH,d,J=8.4Hz),7.01(lH>t,J=7.4Hz>,7.22-7.27(2H,m ),7.33-7.40(4H,m),7.53(2H,d,J=9.0Hz),8.30 and 8.48(each lH.each s). IR(CHC13):3452,3028,3022,3015,2925,2870,1708,1654,1590,1514,1478 /cm. [a]D=+59.5° (MeOH,c=l.01,23=).
No.2a-128 d6-DMSO 300MHz 0.84(lH,d,J=9.9Hz), 1.06 and 1.19{each 3H,each s), 1.37-2.37(14H,m),3.79(1 H, m),5.35-5.51(2H,m),6.08(lH,d,J=8.7Hz),6.85-6.90(lH,m),7.18-7.23(2H,m),7. 35-7.38(2H，m),8.42(lH,s),12.00(lH，s). IR(Nujol):3395,3345,2925,2866r2623,2506,1697,165S(1638,1597,1557 /cm. [o:]D二+26.0。（MeOH，c=1.01,23t：). m.p. 164.0 -166.0^2 經濟部中央標準局員工消費合作社印製
No.2a-129 CDC13 300MHz I. 01(lH,d,J = 10.0Hz), 1.17 and 1.25(each 3H，each s)，l.54-2.52(14H,m),4.34(1 HIm),5.36-5.57(2H,m),6.42(lH,d,J=8.6Hz)f7.51.7.60(2H,m),7.77(lH,dd,J=1.8 and 8.6Hz),7.85-7.96(3H,m),8.24(lH,bs). IR(CHC13):345 1,3060,3028,3010,2925,2870,1708,1652,1629,1600,1517,1502 / cm.
[ajD = + 68.6° (MeOH，c=1.00,22t：). 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公董） 205 513422 A7 B7 五、發明説明（202 ) 經濟部中央標準局員工消費合作社印製
No.2a-130 CDC13 300MHz l. 02(lH,d,J=10.2Hz),1.04 and 1.26(each 3H,each s),1.54-2.52(14H,m)f4.41(l H,m),5.41-5.58(2H,m)f6.14(lH,d,J=9.〇Hz),7.43.7.59<4H,m),7.85-7.92(2H,in)>8. 27(lH,dd,J=1.8 and 7.2Hz). IR〈CHC13):3436,3032,3010,2924,2870,2664,1708,1652,1512,1498 /cm· [a]D=+93.9〇 (MeOH,c=1.00,22t：) 111^.94.0-96.0^ No.2a-131 [a]D=+50.2a (MeOH，c=0.95,2lt：). No.2a-132 [a]D=+10.9〇 (MeOHpOWJlC)· No.2a-133 [a]D=+60.4〇 (MeOH,c=LOO,2lt：). ； No.2a-134 [a】D=+33.5° (MeOH，c=1.01，23t：). No.2a-135 [¢^0=+52^(1^01^=1.01,231).m. p. 180.0 -182.0*C
No.2a-136 [a]D=+35.3〇 (MeOH,c=1.02,23t：). m.p.79.0-80.OC 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 206 -one. (請先閱讀背面之注意事項再iHF本頁) -裝. 訂 線 513422 A7 B7 五、發明説明（2〇3 ) 經濟部中央標準局員工消費合作社印製
No.2a-137 CDC13 300MHz 0.97(lH,d，J=10.2Hz)，l.ll and 1.22(each 3H,each s),1.43(3H，t,J=6.9Hz)，1.52 •2.44(14H，m)，4.03(2H，q,J=6.9Hz)，4.26(lH,m),5.33-5.50(2H,m),6.19(lH，d，J=8· 7Hz),6.88-7.00(611,111),7.65-7.68(211,111). IR<CHC13):3455,3031,3024,3014,2988,2925,2870,1741,1708,1649,1602,1521,1 504,1490 /cm. (a]D=+52.0〇 (MeOH,c=1.01,23t：). No.2a-138 CDC13 300MHz 0.97(lH,d,J=10.2Hz),l.ll and 1.22(each 3H,each s), 1.35(6H,d,J=6.〇Hz), 1-53 -2.46(14H,m),4.25(lH,m),4.51(lH,m),5.33-5.50(2H,m),6.12(lH,d,J=9.0Hz),6.8 7-6.99(6H,m)f7.65-7.68(2H,m). IR(CHC13):3454,3031,3014,2980,2925,2870,1741,170S, 1649,1602,1522,1490 / cm. [a】D=+50.0° (MeOH,c=l.05,22=). No.2a-139 CDC13 300MHz l. 00(lH,d,J=10.2Hz)>1.16 and 1.24(each 3H,each s), 1.59-2.52(14H,m),4.31(1 H，m)，5.40.5.53(2H，m)，6.36(lH，d,J=8.7Hz)，6.70(lH，d,J=1.5Hz)，7.12(lH,m)，7.3 0(lH，m)，7.47(lH，dd，J=0.6 and 8.lHz),7.61(lH，d，J=8.4Hz). IR(CHCi3):3449,3243,3029t3022f3013,2925,2871,1707,1631,1542,1505 /cm. [a]D=+63.4〇 (MeOH,c=1.00,23t：). m. p.178.0-179.Ot：
No.2a* 140 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 207 (請先閱讀背面之注意事項再本頁) 訂 線 513422 A7 B7 五、發明説明（204 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 〇.97(lH,d,J=10.2Hz),1.18 and 1.23(each 3H,each s),l.57-2.50(14H,m),4.35(1 H,m),5.32-5.55(2H,m),6.42(lH,d,J=8.7Hz),6.70(lH,d,J=1.5Hz),7.21-7.24(2H m),7.46(lH,m),7.76(lH,m),7.86(lH,d,J=3.0Hz),10.20(lH,s). IR(CHC13):3465,3010,2924,1739,1604,1546,1504 /cm. 〇]D=+39.4e (MeOH,c=1.01,22t：)· m.p.167.0-168.OX：. No.2a-141 CDC13 300MHz 0.99(lH,d,J=10.2Hz),1.14 and 1.24(each 3H,each s),1.55-2.44(14H,m),3.84(3 H,s)，4.27(lH，m)，5.34-5.52(2H,m),6.28(lH,d，J=9.0Hz),6.91 and 7.47(each 2H, each d,J=9.0Hz),6.98 and 7.14(each lH,each d,J=16.5Hz)f7.54 and 7.70(ea ch 2H,eachd,J=8.7Hz). IR(CHC13):3453,3025,3015,2925,2870,2839,1740,1708,1649,1602,1510,1493,1 470 /cm. [a]D=+73.4° (MeOH,c=1.02,22t：). m.p.l55.0-157.0t： No.2a-142 CDC13 300MHz 0.97(lH,d,J=l〇.2Hz),l.ll and 1.23(each 3H,each s), 1.52-2.45(14H,m),3.79(3 H，s)，4.27(lH,m),5.34-5.50(2H,m)，6.24(lH，d,J=9.0Hz)，6.49 and 6.62(each 1H, each d,J=12.3Hz),6.77 and 7.16(each 2H,each d,J=8.7Hz),7.32 and 7.59(ea ch 2H,eachd,J=8.lHz). IR(CHC13):3453,3025,3014,2925,2870,2839,1739,1708,1649,1606,1510, 1494 /cm. [a]D=+60.7e (ΜβΟΗ,ο=0.99,22Χ：). 本紙張尺度適用中國國家榡準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再iHF本頁) 裝_
、1T 線 208 513422 A7 B7 五、發明説明（205
No.2a-143 [a]D=+57.3° (MeOH,c=1.01，23t：)·
No.2a-144
[a]D=+12.20 (MeOH，c=1.00,23t：). m.p.114.0-116.O^C
No.2a-145 CDC13 300MHz 0.95(lH,d，J=10.2Hz),1.10 and 1.21(each 3H,each s),1.52-2.44(14H,m)，4.25(l H，m)，5.33-5.49(2H,m),6.37(lH，d,J=8.7Hz)，7.45-7.47(3H，m)，7.62-7.66(2H，m)，7· 69 and 7.80(each 2H,each d,J=7.5Hz,). IR(CHC13):3449,3058,3027,3012,2925,2870,1708,1655,1513,1481,1043 /cm. [a]D=+61.0〇 (MeOH,c=1.01,23t：).
No.2a-146 CDC13 300iMHz 0.95(lH,d,J=10.5Hz),1.09 and 1.21(each 3H,each s), 1.50-2.41(14H,m),4.25(1 H,m),5.33-5.49(2H,m),6.33(lH,d,J=8.4Hz),7.49.7.61(3H,m),7.91.7.92(2HIm),7. 82 and 7.97(each 2H,each d,J=S.7Hzf). IR(CHC13):3447,3029,3023,3015,2925,2870,1708,1660,1514,1484,1321,1161 / cm. 經濟部中央標準局員工消費合作社印製 [ct】D=+62.0e (MeOH，c=1.00,22t：).
No.2a-147 CDC13 300MHz 0.97(lH,dfJ=10.2Hz)(1.12 and 1.23(each 3H,each s), 1.52-2.46( 14H,m),2.5 1(3 H,s),4.26(lH,m),5.34.5.51(2Hfm),6.23(lH,d,J=8.4Hz),7.26 and 7.G4(each 2H, each d,J=8.4Hz). 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 209 513422 A7 B7 五、發明説明（2Q6 經濟部中央標準局員工消費合作社印製 IR(CHC13):3453,3027,3015,2925,2870,2665,1708,1648,1596,1516,1484 /cm. [a]D=+67.7d (MeOH,c=0.82,22t：). No.2a-148 [a]D=+72.5〇 <Me0H,c=1.01,25t：). No.2a-149 ^ [a]D=+67.8a (MeOH，c=0.98,25t：)· No.2a-150 CDC13 300MHz 0.94(lH,d,J=10.2Hz),1.10 and 1.23(each 3H,each s), 1.52-2.50(14H,m),4.22(1 H,m),5.36-5.55(2H,m),6.48(lH,d,J=8.4Hz),8.35(lH,s),8.90(lH,s). IR(CHC13):3443,3374,3091,3024,3012,2925,2871,1709,1652,1525,1494 /cm. [a]D二+58.1° (MeOH，c=1.01，23X：)·-m.p.120.0-122.Ot： No.2a-151 [a]D=+40.6° (MeOH,c=1.01，23t：)· No.2a-152 CDC13 300i\IHz 0.96(lH，d，J=10.5Hz)，1.10 and 1.24(each 3H，each s)，1.50-2.50(14H，m)，2.71(3 H，s)，4.26(lH，m)，5.37-5.51(2H，m)，6.02(lH，d，J=9.0Hz)，8.73(lH，s). IR(CHC13):3463,3435,3087,3025,3014,2925,2870,1708,1649,1523,1503 /cm. [ajD二+54.1° (MeOH，c=1.02,22t：). No.2a-153 CDC13 300MHz (請先閱讀背面之注意事項再本頁) _裝- 訂 線 本纸張又度適用中國國家標準（CNS ) A4規格（210X 297公釐） 210 513422 A7 B7 五、發明説明（2〇7 ) 0.95(lH,d，J=9.9Hz),1.11 and 1.23<each 3H,each s)，1.50-2.50(14H,m)，2.50(3 H,s),4.26(lH,m),5.36-5.51(2H,m),6.01(lH,d,J=8.4Hz),6.88(lH,d,J=5.lHz),7.26 (lH,d,J=5.1Hz). IR(CHC13):3469,3431,3025,3013,2925,2871,2664,1708,1639,1544,1505 /cm. [a]D=+35.8〇 (MeOH，c=1.03,22t：)·
No.2a-154 CDC13 300MHz 0.95(lH,d,J=9.9Hz),1.10 and 1.22(each 3H,each s),1.52.2.46(14H,m),2.51(3 H,d,J=1.2Hz),4.26(lH,m),5.34-5.50(2H,m),6.00(lH,d,J=8.4Hz),6.73(lH,dd,J=5. 1 and3.6Hz),7.29{lH,d,J=3.6Hz). IR(CHC13):3450,3431,3026,3011,2925,2869,1739,1708,1639,1547,1508 /cm. [a]D=+50.5〇 (MeOH，C=1.01，22r).
No.2a-155 CDC13 300MHz 0.99(lH，d，J=10.2Hz),1.19 and 1.25(each 3H，each s)，l.53-2.48(14H,m)，4.31(1 H,m),5.36.5.51(2H,m),6.79(lH,d,J=9.3Hz),7.29(lH,m),7.41(lH,m),7.48(lH,s), 7.51(lHtm),7.66(lH,d,J=8.1Hz). IR(CHC13):3436,3029,3024,3015,2925,2871,2670,1708,1659,1598,1510 /cm. [a]D=+69.1〇 (MeOH,c=1.01,22r). 經濟部中央標準局員工消費合作社印製 (請先閲讀背面之注意事項再本頁)
No.2a-156 CDC13:CD3OD=10:l 300MHz 0.99(lH,d,J=9.9Hz),l.ll and 1.21(each 3Hteach s), 1.56-2.58(14Hfm),4.22(1
• I H,m),5.35-5.59(2H,m),6.83(lH,d,J=8.4Hz)t7.48(lH,d,J=8.4Hz),7.61(lHtdd,J=l. j 5 and S.4Hz),8.09(lH,d,J=1.5Hz),8.12(lH,s). IR(KBr):3422,3 115,2985,2922,2869,2609,1708,1636,1578,1529,1470 /cm. [a]D=+62.8〇 (MeOH,c=1.01,22t：). 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 211 513422 A7 B7 五、發明説明（208
No.2a-157 [a】D=+40.0° (!^0£[，。=0.95,22^：). No.2a-158 CDC13 300MHz 1.00(lH,d,J=10.5Hz),1.17 and 1.24(each 3H,each s), 1.54-2.50(14H,m),4.34(l H,m),5.36-5.52(2H，m),7.80(lH，d,J=9.0Hz),9.30(lH，s). IR(CHC13):3410,3122,3030,3012,2925,2871,2668,1709,1667,1538,1466 /cm. [a】D=+44.9e (]\^〇艮。=0.99,22=)· No.2a-159 __ CDC13 300iMHz 0.97(lH，d，J=10.2Hz),1.13 and 1.22(each 3H，each s),1.55-2.43(14H，m),3.03(6 H,s),4.23(lH,m)>5.32.5.51(2H,m),6.16(lH,d,J=8.7Hz),6.87 and 7.63(each 2H, each d,J=8.7Hz). IR(CHC13):3457,3028,3006,2924,2870,2654,1739,1709,1637,1608,1608,1534,1 501 /cm.[a]D=+64.8° (MeOH，c=1.01，22t：). (請先閱讀背面之注意事項再本頁) 裝_ 訂 經濟部中央襟準局員工消費合作社印製
No.2a-160 d6-DMSO 300MHz 0.83(lH,d,J=9.9Hz),1.02 and 1.19(each 3H,each s), 1.38-1.6l(3H,m)t 1.90-2.3 2(llHfm)f3.90(lHfm),5.41-5.44(2H,m)f7.32(lH,dd,J=0.9 and 7.2Hz)t7.45-7.60 (2H,m),7.77(lH，dd，J=0.9 and 7.8Hz)，8.03(lH,d，J=6.9Hz)，12.40(lH，s). IR(Nujol)：33 15,2924,2856,2656,2535, Π37,1703,1637,1598,153 1,1541 /cm. | [a]D=+78.5e (MeOH,0=1.01,24^). | m.p.161.0-162.Ot： 線 本紙張尺度適用中國國家標準（CNS ) A4規格（2丨〇乂297公釐） 212 513422 A7 B7 五、發明説明（2〇9 ) 經濟部中央標準局員工消費合作社印製
No.2a.161 [a]D=+65.3e (MeOH,c=1.00,22t：)· No.2a-162 CDC13 300MHz 0.99(lH,d,J=10.2Hz),L13 and 1.25(each 3H,each s),l.53-2.45(14H,m),4.30(1 H,m),5.36-5.51(2H,m),6.32(lH,d,J=8.4Hz),7.88 and 8.28(each 2H,each d,J=9. 0Hz). IR(CHC13):3448,3029,3016,2925,2870,1708,1664,1602,1527,1484,1347 /cm. [a]D=+72.7° (MeOH,c=1.02,22X：). No.2a-163 CDC13 300MHz 0.96(1H,d，J=10.2Hz),1.11 and 1.23(each 3H，each s),1.55-2.51(14H，m),4.26(1 H,m),5.36-5.57(2H,m),6.68(lH,d>J=7.8Hz)>7.41(lH,dd,J=4.8 and 8.1Hz),8.20( lH,d,J=8.lHz),8.66(lH,d,J=4.8Hz),9.00(lH,s). IR(CHC13):3448,3026,3013,2925,2870,2534f 1709,1658,1590,1515,1471 /cm. [a]D=+71.3〇 (MeOH,c=1.01,22t：). No.2a-164 [a]D=+40.8° (MeOH,c=0.98,22<C). No.2a-165 CDC13 300MHz 0.96(lH,d,J=10.5Hz),l.ll and 1.24(each 3H,each s), 1.55-2.52(14H,m),4.24(1 H,m),5.37-5.57(2H,m),6.63(lH,d,J=7.8Hz),7.59 and 8.63(each 2H each d,J= 6.0Hz). IR(CHC13):3447,3346,3028,3016,2925,2870,2538,1941,1708,1662,1556,1516 / cm. 請先， 閱 讀 背 面參 之 注 意 事 項 t 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 213 Ο 1 Ο - 513422 A7 B7
五、發明説明（21Q 經濟部中央標準局員工消費合作社印製 [a]D=+75.4e (MeOH,c=1.01,22t：). No.2a-166 CDC13 300MHz 0.97(lH,d，J=10.2Hz)，l.ll and 1.22(each 3H，each s),1.51-2.44(14H，m),2.95(6 H, s)，4.25(lH,m),5.33_5.50(2H，m),6.19(lH，d,J=8.7Hz)，6.77 and 6.97(each 2H, each d,J=8.4Hz),6.94 and 7.65(each 2H,each d,J=9.〇Hz). IR(CHC13):3453,3024,3016,2924,2871,2806,1739,1708,1647,1612,1604,1515,1 490 /cm. [ct】D=+53.r (MeOH,c=1.02,23t：)· m.p.104.0-105.5t： No.2a-167 CDC13 300MHz I. 01(lH,d,J=9.9Hz),1.19 and 1.26(each 3H,each s),1.56-2.53(14H,m),4.37(l H, m),5.35-5.55(2Hfm),6.47(lH,d,J=8.4Hz),7.61-7.71(2H,m)>7.79(2H,s),7.89-7. 97(2H,m),8.27(lH,d,J=2.1Hz),8.66-8.73(2H,m). IR(CHC13):3450,3024,3014,2925,2870,2667,1707,1650,1531,1509 /cm· [a]D=+70.5〇 (MeOH,c=1.00,22t：). No.2a-168 CDC13 300MHz I. 02(lH,d,J=10.2Hz)f1.20 and 1.26(each 3H,each s),1.56-2.50(14H,in),4.38(l H,m),5.36-5.56(2H,m),6.51(lH,d,J=8.4Hz)l7.61.7.93(7H,in)f8.74(lHtd,J=8.4Hz ),9.15(lH,s). IR(CHC13):3517,3451,3060,3028,3011,2925,2870,2664,1709,1651,1519,1498/c m. [a]D=+54.4〇 (ΜβΟΗ,ο=1.00,23Τ：). (請先閲讀背面之注意事項再本頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 214 513422 A7 B7 五、發明説明（211) 經濟部中央標準局員工消費合作社印製
No.2a-169 CDC13 300MHz 〇.96(lH,d,J=10.5Hz),l.D9 and 1.21(each 3H,each s),1.50-2.44(14H,m),3.85(3 H,s),4.24(lH,m),5.32-5.48(2H,m),6.19(lH,d,J=8.4Hz),6.94 and 7.45(each 2H, each d,J=9.0Hz),7.11 and 7.45{each 2H,each d,J=8.7Hz). IR(CHC13):3516,3453,3029,3009,2925,2870,2840,2665,1708,1650,1593,1515,1 493,1482 /cm· [a]D=+57.8° (MeOH，c=1.00,23r). No.2a-170 CDC13 300MHz 0.98(lH,d,J=10.2Hz),1.15 and 1.24(each 3H,each s), 1.52-2.50(14H,m)>4.28(l Η,ιη),δ.33-5.54(2Η,ιη)>6.25(1Η,(Ι^=8.2Ηζ),7.38-7.44(2Η,ιη),7.74(1Η,5),7.81-7. 86(2H,m). IR(CHC13):3517,3448,3427,3024,3013,2925,2870,2669,1708,1650,1562,1535,1 500 /cm. [a】D=+61.6〇 (MeOH，c=1.00,23t：)· No.2a-171 CDC13 300MHz 0.96(lH，d，J=10.2Hz，l.ll and 1.22(each 3H，each s)，1.52-2.42(14H，m)，2.48(3 H，s),4.21(lH，m)，5.31-5.52(2H，m)，6.06(lH，d，J=8.2Hz)，6.97 and 7.59(each 1H， each d，J=1.2Hz). IR<CHCi3):3452,3113,3028,3007,2925,2870,2669,1708,1645,1554,1509 /cm. [o:]D=+52.4〇 (MeOHlc=1.00,23<C).
No.2a-172 CDC13 300MHz .96(lH,d,J=10.2Hz),l.09 and 1.28(each 3H，each s),1.50-2.40(UH，m),2.69(3 0 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再本頁) -裝· 訂 線 215 513422 A7 B7 五、發明説明（212 經濟部中央標準局員工消費合作社印製 H,s),4.24(lHfm),5.35.5.51<2H,m)>5.96(lHfd,J=8.7Hz),7-.03 and 7.0T(each 1H, each d,J=5.4Hz). IR(CHC13):3451,3031,3013,2925,2870,2666,1708,1647,1542,1497 /cm. [o:】D=+51.2° (MeOH,c=1.00,23t：). No.2a-173 CDC13 300MHz 〇.95(lH,d,J=10.2Hz),l.l〇 and 1.23{each 3H,each s),l.〇0-2.45(14H,m)f4.22(l H,m),5.35-5.49(2H,m),6.05(lH,d,J=8.4Hz),7.26 and T.75(each lH,each d,J=l. 5Hz). IR(CHC13):3451,3011,3029,3011,2925,2870,1708,1652,1538,1500 /cm. [a]D=+50.6e (MeOH，c=1.01，23t：)· No.2a-174 CDC13 300MHz 0.96(lH，d，J=10.2Hz)，1.13 and 1.23(each 3H，each s)，1.52-2.50(14H，m)，4.29(l H,m),5.35-5.51(2H,m),7.02(lH,d,J=8.4Hz),7.32 and 8.16(each lH.each d,J=3. 9Hz). IR(CHC13):3417,3115,3023,3014,2925,2870,1708,1645,1530 /cm. [a]D=+48.8〇 (MeOH,c=1.02,23t：). No.2a-175 CDC13 300MHz 0.97(lH,d,J=10-2Hz), 1.14 and 1.23(each 3Hfeach s), 1.50-2.52(14H,m),2.52(3 H>s)t4.29(lH,m),5.34.5.51(2H,m),7.78(lH,d,J=9.0Hz)I7.24 and 7.52(each 1H, each d,J=5.4Hz). IR(CHCi3):3329,3093,3023,30 15,2924,287 1,1708,1640,1526 /cm. (a ]D=+45.0〇 (MeOH,c=i.OL,23t：). (請先閱讀背面之注意事項再HP本頁) -裝· 、訂 線 本紙張又度適用中國國家標準（CNS ) A4規格（210X 297公釐） 216 五 、發明説明（213) A7 B7 經濟部中央標準局員工消費合作社印製
No.2a.176 CDC13 300MHz 0.95(lH,d,J=10.5Hz),1.09 and 1.23(each 3H,each s), 1.52-2.46(14H,m),2.40(3 H,d,J=0.9H2),4.24(lH,m),5.35-5.51<2H,m),6.05(lH,d,J=8.7Hz),6.95(lH,m),7.5 7(lH,d,J=3.3Hz). IR(CHC13):3517,3444,3103,3024,3013,2926,2870,1739,1708,1649,1636,1507/c m. {a]D=+54.8° (MeOH，c=1.01,23t：)· m.p.97.0-99.Ot： No.2a-177 CDC13 300MHz 0.97(lH,d,J=10.2Hz),1.11 and 1.23(each 3H,each s)，1.52-2.45(14H，m),3.93(3 H，s)，4.27(lH，m)，5.34-5.50(2H，m)，6,35(lH，d，J=3.3Hz)，7.80(lH，d，J=S.7Hz)，8.10 (lH，d，J=3.3Hz). IR(CHC13):3395,3121,3031,3019,3012,2925,2871,1739,1709,1640,1557,1533 / cm. [a】D=+22.8〇 (MeOH，c=1.01，23t：). m.p.109.0-112.Ot： No.2a-178 CDC13 300MHz 0.96(lH，d，J=10.5Hz)，1.10 and 1.23(each 3H,each s)，l.51-2.45(14H，m)，4.24(1 H，m)，5.35-5.50(2H，m)，6.09(lH，d，J=8.4Hz)，7.17-7.31(6H,m)，7.95(lH,d，J=1.5Hz ). IR(CHC13):3510,345 1,3062,303 1,3022,30 11,2925,2870,2662,1708,165 1,1582,1 5351497,1477/cm. [a)D=+47.9〇 (MeOH,0=1.01,25^). (請先閱讀背面之注意事項再本頁)
、*IT 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 217 0 17 - 513422 A7 B7 五、發明説明（214 經濟部中央標準局員工消費合作社印製
No.2a-179 CDC13 300MHz 0·96(1Η,d,J=10.2Hz),1.14 and 1.24(each 3H，each s)，l.52-2.48(14H，m)，4.30(1 H,m),5.36-5.52(2H,m),6.73(lH,d,J=9.0H2),6.26 and 7.37(«ach lH,each d,J=6. 0Hz). IR(CHC13):3509,3429,3115,3094,3025,3014,2925,2871,2666,1708,1649,1529,1 510 /cm. [a]D=+51.0° (MeOH,c=l.02,25X：). No.2a-180 CDC13 300MHz 〇.95(lH,d,J=10.2Hz),1.14 and 1.24(each 3H,each s), 1.52-2.46(14H,m),3.89(3 H，s)，4.21(lH，m)，5.35-5.50(2H，m)，6.05(lH,d，J=8.4Hz)，6.46 and 7.04(each 1H, each d，J=1.8Hz). IR(CHC13):3516,3450,3114,3031,3010,2925,2871,1708,1648,1546,1511,1477 / cm. [a ]D=+49.1° (Me011^=1.01,251). No.2a-181 CDC13 300MHz 0.97(lHfdfJ=10.2Hz),1.14 and 1.23(each 3H,each s), 1.52-2.48(14H,m),2.42(3 Hfs),4.31(lH,m),5.34-5.52(2H,m),8.07(lHtd,J=9.3Hz),7.27 and 8.17(each 1H, each d,J=3.3Hz). IR(CHC13):3510,3301,3112,3023,3007,2924,2871,2663,1708,1636,1534 /cm. [a]D=+41.0° (ΜθΟΗ,ο=0.96,25Τ：).
No.2a-132 CDC13 300MHz 0.96(lH,d,J=10.2H2),l.ll and 1.23(each 3H,each s), 1.53-2.46( 14 H,m),2.5 1(3 本紙張·尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再本頁) 訂 線 218 513422 A7 B7 五、發明説明（215 ) H,s)，4.21(lH,m)，5.35-5.51(2H，m),6.05(lH,d,J=8.lHz)，7.26 and 7.78(each 1H, each d,J=1.8Hz). IR(CHC13):3509,3450,3109,3024,3012,2925,2870,2666,1708,1650,1535,1 498,1471 /cm. [a]D=+52.9° (MeOH，c=0.95,25t：). No.2a-183 CDC13 300MHz 0.96(lH,d,J=10.5Hz),1.12 and 1.22(each 3H,each s), 1.52-2.46(14H,m),4.25(1 H, m),5.33-5.51(2H>m),6.17(lH,d,J=8.7Hz),7.01-7.05(3H,m).7.14 and 7.62(eac h 2H,each d,J=8.7Hz),7.27-7.34(2H,m). IR(CHC13):3428,3026,3015,2925,2870,2666,1739,1708,1643,1613,1594,1526,1 499 /cm. [a]D=+64.8〇 (MeOH,c=1.02,23t：). No.2a-184 CDC13 300MHz I. 01(lH,d,J=10.2Hz), 1.18 and 1.26(each 3H,each s), 1.55-2.50(14H,m),4.35(1 H,m),5.35-5.55{2H,m),6.42(lH,d,J=8.7Hz),7.46-7.52<2H,m).7.73(lH,dd,J=1.8 and 8.4Hz),7.83.7.89(2H,m),8.21(lH,m),8.59(lH,d,J=1.5Hz). IR(CHC13):3451,3031,3014,2925,2870,2660,1739,1708,1650,1604,1513,1463 / cm. [a]D=+58.3〇 (MeOH，c=1.00,23t：)· (請先閱讀背面之注意事項再本頁) 訂 線 經濟部中央標準局員工消費合作社印製
No.2a-185 CDC13 300MHz 1.00(lH,dtJ=10.2Hz),1.18 and 1.25(each 3H,each s), 1.55-2.50(14H,m),4.34(1 | ! H,m),5.35-5.54(2Hfm),6.36(lH(d,J=8.7Hz),7.37(lH,t,J=7.4Hz),7.50(lH,m),7.5 | 7-7.59(2H,m),7.79(lH,dd,J=1.8 and 8.1 Hz),7.99( 1 H,d,J=7.8Hz),8.39( 1 H,d,J = 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 219 513422 A7 B7 五、發明説明（216 經濟部中央標準局員工消費合作社印製 1·8Ηζ). IR(CHC13):3451,3030,3<)20,2870,2665，1708,1652，1632，ie〇3,1586,1514,1469，l 448 /cm. [a】D=+59.4。（MeOH，c=1.01，24t). No.2a-186 CDC13 300MHz 1.00(lH,d,J=10.5Hz),1.17 and 1.25(each 3H,each s), 1.54-2.50(14H,m),4.33(1 H，m)，5.35-5.54(2H,m)，6.37(lH，d，J=8.7Hz),7.37(lH,t，J=7.4Hz)，7.51(lH，t，J=7.8 Hz),7.56(lH,m),7.70(lH,dd,J=1.2 and 8.4Hz),7.97(3H,m). IR(CHC13):3451,3030,3014,2924,2870,2671,1739,1708,1652,1577,1517,1488,1 471 /cm. ; [a]D=+72.2° (MeOH,c=1.00,24t：). No.2a-187 CDC13 300MHz 1.00(lH,d,J=9.8Hz),l,18 and 1.25(each 3H,each s), 1.54*2.53(14H,m),4.07(3 H,s),4.37(lH,m),5.30-5.54(2H>m),7.34(lH,m),7.47(lH,s),7.47.7.60(2H,m),7.93( lH,d,J=7.8Hz),8.43(lH,s),8.49(lH,d,J=9.0Hz). IR(CH€13):3397,3074,3027,3020,3009,2924,1738, Π08,1647,1633,1534,1465,1 453 /cm. [a】D=+43.7° (MeOH，c=1.01，25t：)· No.2a-188 CDC13 300MHz 0.97(lH,d,J=10.2Hz),l.ll and 1.23(each 3H,each s), 1.53-2.50( L4H,m).4.23( 1 H,m)l5.37.5.50(2Htm)f6.10(lHtd,J=9.0Hz),6.20(lH,m),6.51(iH,m),6.97(lH,m), 10.81(lH,bs). IR(CHC13):3450,3236,3 112,3029,3015,2925,287 L,2645,170 1,16 16,1558,15 L6 (請先閲讀背面之注意事項再^!本頁) 裝- 訂 綉 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 220 513422 A7 B7 五、發明説明（217) 經濟部中央標準局員工消費合作社印製 /cm. [a]D=+50.69 (MeOH,c=1.01,24t：). No.2a-189 CDC13 300ιΜΗζ 〇.94(lH,d,J=9.9Hz),l.ll and 1.23(each 3H,each s), 1.50*2.46(14H,m),3.93(3 H,s)，4.18(lH，m)，5.35-5.52(2H，m),6.03(lH，d，J=9.3Hz)，6.09(lH,m)，6.48(lH，m), 6.73(lH,m). IR(CHC13):3452,3102,3028,3007,2925,2871,2666,1739,170S, 1650,1536,1499,1 471 /cm. [a]D=+49.8°(MeOH,c=1.01，23t：)· ιη.ρ.101.δ-103.5ΐ： No.2a-190 CDC13 300MHz 0.94(lH,d,J=10.2Hz),l.ll and 1.21(each 3H,each s), 1.54-2.47(14H,m),4.23(1 H,m),5.33.5.52(2H,m),6.06(lH,d,J=9.0Hz)>6.34(lH,m),6.75(lH,m),6.36(lH,m), 9.71(lH,bs). IR(CHC13):3470,3215,3030,3020,3010,2925,2871,2664,1709,1613,1564,1510 /cm. [or]D=+43.3a (MeOH，c=1.01，24t：)· No.2a-191 CDC13 300MHz 0.96(lH，d，J=10.2Hz)，l.ll and 1.22(each 3H，each s),1.55.2.44(14H，m),3.66(3 H,s),4.20(lHfm)(5.35-5.51(2H,m),5.93(lH,d,J=8.4Hz),6.27(lH>dd,J = 1.3 and 2. 7Hz),6.56(lHft,J=2.7Hz),7.19(lH,t,J=1.8Hz). IR(CHC13):3452,3031,30 18,3006,2925,287 1,2662,1736,17 10,1634,1609,1556,1 498 /cm. (請先閱讀背面之注意事項再本頁) 裝· 絲 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 221 _ O O 1 - 513422 A7 B7 五、發明説明（218 ) 經濟部中央標準局負工消費合作社印製 [a】D=+43.1° (MeOH，c=1.01，23t：). No.2a-192 CDC13 300MHz 0.96(lH,d,J=10.5Hz),l.ll and 1.21(each 3H,each s), 1.43(3H,t,J=7.5Hz), 1.54 .2.44(14H,m),3.93(2H,q,J=7.5Hz),4.21(lH,m),5.33-5.51(2H,m)f5.94(lH,d,J=8. 4Hz),6.27{lH,dd,J=1.8 and 2.7Hz),6.62(lH,t,J=2.7Hz),7.26(lH,t,J=1.8Hz). IR(CHC13):3630,3452,3032,3018,3006,2925,2871,2661,1735,1710,1633,1610,1 555,1497 /cm. [a]D=+40.1° (MeOH,c=1.00,23t：). No.2a-193 : CDC13 300MHz 0.95(lH,d,J=10.2Hz),1.10 and 1.22(each 3H,each s), 1.53-2.49(14H,m),2.58(3 H,s),4.21(lH,m)l5.35-5.54(2H,m),6.15(lH,d,J=8.lHz)>6.52(lH,dd,J=l.S and 3. 6Hz),7.29(lH,t,J=3.6Hz),7.94(lH,t,J=1.8Hz). IR(CHC13):3516,3450,3410,3152,3027,3015,2925,2871,2670,1732,1648,1574,1 509 /cm. [a]D=+45.0° (MeOH,c=1.01，25t：). No.2a-194 CDC13 300MHz 0.99(lH，d，J=10.2Hz),l.ll and 1.24(each 3H，each s),1.52-2.53(14H，m),4.34(1 H,m),5.33-5.57(2H,m)f6.2 l(lH,d,J=8.6Hz),7.35-7.50(2H,m),7.83(1H,s),7.86( 1H, m).8.31(lH，m). IR(CHC13):3443,3067,30 13,2925,2870,2665,1708,165 1,15 15,1493 /cm. [a]D=+55.7° (MeOH,(:=1.01,231).
No.2a-195 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再本頁) 、tr 線 222 513422 A7 B7 五、發明説明（219 CDC13 300MHz (請先閲讀背面之注意事項 l. 01(lH,d,J=10.0Hz),1.06 and 1.26(each 3H,each s), 1.50-2.64(14H,m),2.68(3 H,s),4.40(lH,m),5.36-5.61(2H,m),6.02(lH,d,J=9.4Hz),7.3〇.7.42(2H,m),7.73.7. 86(2H，m). IR(CHC13):3510,3434,3062,3029,3014,2924,2871,2669,1708,1650,1563,1539,1 500 /cm.
[a]D=+72.4° (MeOH，c=1.00,23r). m. p.111.0*112.Ot：
No.2a-196 CDC13 300MHz 0.42 and 1.04(each 3H，each s),0.80(lH,d，J=10.0Hz)，l.ll-2.48(14H，m),2.24(3 H,s),4.02(lH,m),5.23.5.44(2H,m),5.53(lH,d,J=S.8Hz),7.27.7.31(2H,m),7.42-7. 4S(3H,m),7.93(lH,s). IR(CHC13):3419,3114,3025,3006,2924,2871,2662,1737,1709,1636,1540,1519 / cm.
[a]D二+43.7° (MeOH，c=1.01，23t：).
No.2a-197 CDC13 300MHz 經濟部中央標準局員工消費合作社印製 0.95(lH，d,J:10.0Hz)，1.09 and 1.23(each 3H，each s)，l.54-2.46(18H，m),2.77(4 H，bs)，4.21(lH，m)，5.32-5.54(2H，m)，6.02(lH，d，J=8.6Hz)，7.43(lH，s)· IR(CHC13):3445,3101,3024,3014,2928,2865,2661,1739,1708 1646,1550,1507 / cm.
[cr]D=+51.9〇 (MeOH，c=1.01,23t：).
No.2a-198 CDC13 300MHz 0.96(lH,d,J=10.2Hz),l.ll and 1.22(each 3H,each s), 1.50-2.44( 14H,m),4.24( 1 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 223 513422 A7 B7 五、發明説明（22〇 ) 經濟部中央標準局員工消費合作社印製 H，m),4.42(2H，s),5.35-5.49(2H，m)，6.25(lH，d,J=8.lHz)，7.33(lH，m)，7.43(lH，dd，J = 1.5and 7.5Hz),7.49(lH,d,J=8.lHz),7.60-7.63(lH,m),7.68(lH,dd,J=1.8 and 7. 8Hz),8.02(lH,d,J=1.8Hz),8.19(lH,dd,J=1.5 and 8.1Hz). IR(CHC13):3448,3030,3012,2925,2870,1739,1708,1671,15SS, 1559,1514,1472 / cm. [a]D=+56.9e (MeOH,c=l.01,24t：). No.2a-199 CDC13 300MHz 0.96(lH,d,J=10.2Hz),l.ll and 1.22(each 3H,each s), 1.5l-2.46(14H,m),3.40(l H,m),3.76(lH,m),4.24(lH,m),5.33-5.51(3H,m),6.25(lH,m),7.16(lH,m),7.24-7.3 3(2H，m)，7.46(lH,d，J=7.5Hz)，7.52-7.60(?H，m)，7.85(lH,dd，J=1.8 and 4.5Hz). IR(CHC13):3583,3447,3062,3028,3013,2924,2871,2663,170s, 1651,1600,1557,1 514,1471 /cm. [a ]D=+54.8〇 (MeOH,c=1.00,23^C). No.2a-200 CDC13 300MHz 0.96(lH,d,J=10.2Hz),1.12 and 1.23(each 3H,each s), 1.5l-2.46(14H,m),4.25(l H,m)f5.34-5.51(2H,m),6.25(lHfd,J=8.4Hz),7.02 and 7.10(each,lH,each d,J=l 2.3Hz)，7.23-7.33(4H，m),7.50(lH，m)，7.64(lH，dd,J=1.8 and 7.8Hz)，7.82(lH，d，J = 1.8Hz). IR(CHC13):3450,3060,3025,3014,2925,2871,2662,1708,1653,1596,1542,1513,1 473 /cm. [_=+62.5〇 (MeOH，c=1.00,2‘ir). No.2a-201 ! I CDC13 300MHz ,! 0.95(19,(1^=9.91^2),1.15 and 1.22(each 3H,each s), 1.55-2.60( 14H,m),4.26( 1 (請先閱讀背面之注意事項再本頁) 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 224 513422 A7 B7 五、發明説明（mi 經濟部中央標準局負工消費合作社印製 H,m),5.35-5.63(2H,m),7.14(lH,d,J=9.9Hz),7.34 and 7.40(each,lH,each d,J=l 2.9Hz),7.62-7.73(4H,m),8.25-8.30(2H,m),8.72(lH,d,J=1.5Hz). IR(CHC13):3443,3389,3297,3061,3030,3016,2925 2870,1726,1708 1652,1603, 1521,1483,1472,1309 /cm. [a]D=+61.r (Μ«ΟΗ^=1.01,23ΐ：)· No.2a-202 CDC13 300MHz 〇.96(lH，d，J=10.2Hz),1.09 and 1.22(each 3H,each s)，1.52-2.43(14H,m),2.63(3 H,s),4.25(lH>m),5.33-5.49(2H,m),6.19(lH,d,J=8.4Hz),7.10 and 7.58(each,2H, each d，cJ=9.0Hz)，7.21(lH，m),7.30-7.32(2H，m)，7.46(lH，d,J=7.5Hz). IR(CHC13):3511,3453,3062,3032,3014,2925 2870,1739,170S, 1650,1595,1556,1 516,1482,1471 /cm. [〇:]D=+60.2° (MeOH，c=1.01,25t：). No.2a-203 CDC13 300MHz 0.96(lH,d,J=10.5Hz),1.09 and 1.23(each 3H,each s), 1.52.2.43(14H,m),4.23(l H,m),5.35-5.51(2H,111),5.93(lH,d,J=8.7Hz),6.56(lH,dd,J=0.9 and l.SHz),7.43( lH，t，J=1.8Hz)，7.92(lH，dd，J=0.9 and 1.8Hz).' IR(CHC13):3517,3450,3134,3031,3008,2925,2870,2667,1708,1656,1588,1570,1 514 /cm. [a]D=+46.7e (MeOH,c=0.92,25t：)· No.2b-l [a!D= +25.6° (MeOH，c=1.01,23t：). No.2b-2 [u 1D= +38·9° (MeOH.cd.Ol^H). j (請先閲讀背面之注意事項再本頁)
、1T 線 本纸張尺度適用中國國家標準（CNS ) Λ4規格（210X 297公釐） 225 513422 A7 __B7 五、發明説明（222 ) d2c-1 [a】D= +60.5° (MeOH,c=1.01，22^C). No.2c-2 [a]D= +55,8° (MeOH，c=0.92,22t：). No.2c-3 [a]D= +54,7。（MeOH,c=1.01，22t：)· No.2d-l [a]D= -6.2° (MeOH,c=1.00,2lt：). No.2d-2 [a]D=+15.8 (MeOH，c=0.34,22^C).
No.2d.-3 [α]Ό=+31.6β (MeOH,c= 1.01,22X3). No.2e-1 [a -9.4° (MeOH,0=1.00,221).
No.2e-2 經濟部中央標準局員工消費合作社印製 [a]D= -1.8° (MeOH,c=1.02,23t：). No.2e-3 [a]D= -6.7° (ΜβΟΗ,ο=1.01,23ΧΙ). No.2f-l 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 513422 A7 B7 五、發明説明（223 [a]D= +6.8e (MeOH，c=1.01，23t：)·
No.2f-2 [a]D= -2.6° (MeOH,c=1.00,22t：).
No.2f-3 [a]D= -3.5° (MeOH,c=1.01,22t：).
No.2g-l [a]D= +54,6° (MeOH，c=1.01，24t：)·
No.3a-2 . CDC13 300MHz 0.98-2.15(14H，m)，2.31(2H,t，J=7.2Hz),2.35-2.40(lH,m),3.10-3.20(lH,m), 5.00(lH,d,J=6.9Hz)>5.30-5.48(2H,m),6.75(lH,d,J=10.2Hz),7.38-7.52(6H,m). IR(CDC13):3266,3028,2954,2874,1709,1620,1448,1412,1318,1141,970,892/cm.
[a]D=+20.3 土 0.6* (CHC13,c=1.05,24t：)·
No.3a-3 CDC13 300MHz 0.95-2.00(14H，m),2.20-2.29(3H,m)，3.00-3.08(lH，m)，3.66(3H，s)，5.00(lH,d， 經濟部中央標準局員工消費合作社印製 J=6.6Hz〉，5.13-5.29(2H，m),7·38·7.52(3H，m)，7.59-7.65(2H，m)，7.69· 7.75(2H,m),7.92-7.98(2H,m). IR(CHC13):3376,3018,2946,2868,1727,1594,1436,1395,1322,1157,1095,S90 /cm.
[a ]D=+2.3 土 0.4· (CHC13，c二 1.03,22C). mp.65-66.5^3
No.3a-4 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 227 513422 A7 B7 五、發明説明（) 經濟部中央標準局員工消費合作社印製 CDC13 300MHz 0.93-2.05(14H,m)，2.15-2.22(lH,m)，2.31(2H，t，J=7.2Hz),3.Ol-3.10(lH，m), 5.18-5.31(3H,m)，7.38-7.52(3H,m)，7,58-7.66(2H，m),7.69·7·76(2Η,ιη),7.92· 7.98(2H，m) IR(CHC13):3374,3260,3020,2948,2868,1708,1594,1479,1396,1319,1156,1095,1 052,891/cm. [a]D=+13.1±0.5.(CHC13，c=1.16,24t：)· No.3a-6 CD30D 300MHz 1.04· 1.95(14H，m),2.07(2H，t，J=7.8Hz),2·14.2·22(1Η, m), 2.94-3.00(lH，m), 5.04. 5.25(2H,m),7.36-7.52(3H,m),7.66-7.71(2H,m),7.78-7.85(2H,m),7.91- 7.97(2H,m). IR(KBr):3421,3278,2951,2872,1562,1481,1409,1317,1156,1097,1057,895/cm. [cc]D=-15.3±0.5· (CHC13,〇=1.06,23^：)· mp.105-112^ No.3a.ll CDC13 300MHz 0.90-2.04(14H,m),2.08.2.19(lH,m)l2.35(2H,t,J=7.2Hz),2.95-3.04(lH,m), 5.17- 5.32(3H,m),7.56-7.63(2H,m),7.83.7.95(2H,m). IR(CHC13):3260,3020,2948,286811707,1569,1456,1383,1325,126S, 1160,1088, 1053，1006,892/cm. [a jD=+8.3土0.5· (CHC13，c=1.00,22t：).
No.3a* 16 CDC13 300MHz 0.80-1.90(14H,m),1.98-2.04(lH,m),2.27(2H,tfJ=7.2Hz),2.88(6H,s),2.90- 2.98(lH,m),4.88-5.00(2HIm),5.13(lH,dtJ=7.2Hz)I7.18(lH,d,J=7.5Hz),7.48- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再尽頁) 訂 線 228 513422 A7 B7 五、發明説明（225 7.60(2H，m),8.25-8.33(2H，m)，8.53(lH,d，J=8.7Hz). IR(CHC13):3272,3020,2946,2866,2782,1708,1573,1455,1407,1311,1229,1160, 1142,1070,942,891/cm.
[a]D=-19.7土0·6· (CHC13，c=.1.08,23.5t：).
No.3a-31 CDC13 300MHz 0.80-l.S5(14H,m),2.02-2.08(lH，m),2.20(2H,t，J=7.2Hz)，2.85-2.95(lH，m)， 3.68(3H,s),4.80-4.92(2H,m),4.96(lH,d,J=6.9Hz),7.50-7.70(3H,m),7.92. 7.98(lH,m),8.07(lH,dlJ=8.4Hz),8.29(lH,dd,J=1.5&7.5Hz),8.65 (lH，d，J=8.7Hz). IR(CHC13):3374,3016,2946,2868,1727f1506,1435,1318,1160,1133,1105,1051, 984,890/cm.
[a ]D=-39.3土0.8· (CHC13，c=1.07,22t：).
No.3a-32 CDC13 300MHz 0.80-L90(14H,m),1.95-2.05(lH,m),2.27(2H,t,J=7.2Hz),2.90-2.96(lH,m)f 4.85· 5.00(2H,m),5.23(lH,d,J=6.6Hz)>7.50-7.72(3H,m)l7.95(lH,d,J=8.lHz)l 8.07(lH,d,J=8.4Hz),8.29{lH,dd,J=1.2&7.5Hz),8.66(lH,d,J=9.0Hz). IR(CHC13):3270,3020,2948,2868,1708,1455,1412,1317,1159,1132,1104,1079,1 051,983,891/cm.
[a]D=-29.2±0.6.(CHC13，c=1.08,22t：)· 經濟部中央標準局員工消費合作社印製
No.3a-33 CD30D 300MHz 0.94-1.84(14Hfm),L96-2.08(3H,m),2.77-2.84(lH,m)f4.67-4.84(2H,m),7.55-7.75(3H,m),8.02(lH,d,J=7.8Hz),8.12-8.26(2H,m),8.74(lH,d,J=8.7Hz). IR(KBr):3432,3298,295 1,2872,1564,14 12,1315,1 159,1134,1 107,1082,1058, 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 229 513422 A7 B7 五、發明説明（226 986/cm. [a ]D=-79.9土 1·2· (CH30H，c=1.00,23t：)· No.3a-34 CDC13 300MHz 0.97-1.91(14H,m),2.13-2.20(lH,m),2.42(2H,t,J=7.2Hz),3.00-3.07(lH,m), 5.06-5.24(2H,m),5.33(lH,dfJ=6.9Hz),7.57-7.68(2H,m),7.82-8.00(4H,m), 8.45(lH,d,J=1.2Hz) IR(CHC13):3260,3020,2948,1708,1408,1319,1154,1129,1073,953,893/cm. [a ]D=+20.7土 0.6· (01^13^=1.07,22=). No.3a-35 CD30D 300MHz 1.03.2.20(m,17H),2.97(m,lH),5.02(m,2H),7.64(m,2H),8.00(m,4H),8.43(S,lH). IR(KBr):3360,3285,1562,1407,1316,1153,1130,1075/cm. [a]D=^0 [α]365=+20·9 土 0.6-(CH30H,c=1.04,23t：)· (請先閱讀背面之注意事項再本頁) 裝· 丁 、-'口 經濟部中央標準局員工消費合作社印製
No.3d-l CDC13 300MHz 0.93-2.55(m,17H),3.02(m,lH),5.24(m,2H),6.48(m,lH),7.35-7.60(m,3H)f7.85- 8.00(m,2H) IR(Nujol): 3275,1548,1160,1094,758,719,689,591,557/cm. [a 】D=+19.0土0.6。（¢:11301^=1.010,26.51). 元素分析（〇20 14 26 1^〇45*1/2〇3.1.0142〇七1^1：) 計算値：C, 57.94:H, 6.82;N, 3.38:Ca. 4.83; H 2 O, 4.3 5 實測値：C，5 7.8 0 ; H. 6.68 ; N, 3.68 ;Ca, 5.06; H 2 〇，4.5 0 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 230 513422 A7 B7 五、發明説明（ 227 )
No.3d-6 [cr】D=-20.7土0.6· (CHC13，c=1.00,24t：)· No.3d-7 [a]D=-3.2±0.4.(CHC13:c=1.03,22t：).
mp.65-67*C ，
No.3d-8 [α]〇=·14·5 土 0.5*(CHC13,c=1.07,24t：)· No.3d-9
[a】D=+12.2 土 0.5.(CH30H，c=1.00,23X：)· mp.H9-125，C
No.3d-10 [a 】D=+39.7土0·8· (CHC13，c=1.07,22t：)· No.3d-ll [a】D=+29.2 土 0.7*(011(：13，。=1.06,221)· No.3d-12 經濟部中央標準局員工消費合作社印製 [a】D=+76.4土 1·Γ ((：Η30Η,〇=1·03·24^：)· No.3d-14 [a】D=-20.6士0.6· (¢311(:13,0=1.07,221). No.3d-15 [a 1365=-28.0土0.7· (0^3011^=1.03,24.5^). 本紙浪尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 231 513422 A7 B7 五、發明説明（ 228 ) 經濟部中央標準局員工消費合作社印製
No.3d-16 [a 】D=-8.7 ± 0.5· <CHC13，c=1.06,22t：). No.3d-17 CDC13 300MHz 0.80-2.15(m，24H),2.32(t，J=7Hz，2H)，2.68<t，J=7Hz，2H)，3.02(m，lH)，2.15 (m,24H)，2.32(t，J=7Hz，2H)，2.68(t，J=7Hz，2H)，3.02(m，lH)，5.22(m，2H)，5.38(d，J: 7Hz,lH),7.30(A2B2q-Apart,J=SHz,2H),7.81(A2B2qBpart,J=8Hz,2H),9.86 (br.s,lH). {a]D=^0 [α]365=·9.7士0.5〇 (CHC13，c=1.03,22t：)· No.3d-24 [a 】D=+19.2± 0.6· ((^013/=1.05,23^:). No.3d-26 CD30D 300MHz 0.9〇.2.20(20H,m),2.88(lH,m),3.07(2H,q,J=7.0Hz),5.00-5.40(2H,m)>7.20- 7.60(4Hfm),7.95(lH,m). IR(KBr):3415,3254,1698,1564,1314,1154/cm. No.3d-28 CD30D 300MHz 0.90-2.20(20H,m),2.73(2H,q,J=7.0Hz),2.93(lH,m),5.00.5.30(2H,m),7.40- 7.50(2H,m),7.60-7.77(2H,m). IR(KBr):3435,3280,1562,1323,1304,115 1/cm. No.3d-30 (請先閱讀背面之注意事項再本頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 232 513422 A7 B7 五、發明説明（229) 元紊分析 C20H25BrN〇4SNa Calc.C50.21;H5.27;Brl6.70;N2.93;S6.70;Na4.81 found.C50.22;H5.40;Brl5.57;N2.88;S6.41;Na5.10 IR(KBr):3425r3280,3085,1697,1570,1410,1321,1165,1155/cm.
No.3e-l CD30D 300MHz 0.71(lHfd,J=10.2Hz),1.04(3Hfs)l1.12(3H,s),1.35-2.28(14H,m), 2.42(3H,s),3.17-3.25(lH,m),5.18-5.39(2H,m)t7.37(2H,d,J=8.4Hz),7.75(2Htd,J=8.4Hz). IR(CHC13):3400,3289,2986,2924,2870,1559,1424,1322,1305,1160,1095,1075,1 030/cm.
[a 】D=+25.9土0.7· (¢^301^=1.00,23=). 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 233 513422 A7 B7 五、發明説明（230 鼷於上述實施例得到之化合物，K如下實驗例所示之 方法進行活體内及活體外試驗。 奮驗例1 PGDa受容體之結合實驗 試驗材料及試驗方法 ⑴人血小板膜區分之調製 從健康正常人（成人男性及女性）之靜脈之裝有3.8 %檸檬酸納之塑膠製注射器採取到的血液置入塑膠製試驗 管内，輕輕傾倒混合後，於室溫Μ 1800 rpin，10分鐘離心 分離，採取上清之多血小板血漿[PRP(Platelet rich Plasma)]。將此PRP進一步附諸室溫2300 rpm，22分鐘之 離心分離，得到血小板。所得到之血小板使用hofliogenizer (Ultra-Turrax)而經同質化後，K4t!，2000 rpm，10 分 鐘離心分離進行3次，得到血小板膜區分。膜區分蛋白定 量後，成為2nig/ml，供應結合實驗而於-80TC下冷凍保存 (請先閱讀背面之注意事項再本貢) 訂 經濟部中央標準局員工消費合作社印m ⑵PGD,受容體之結合實驗 於結合反應液（50 bM TrB/HCl，pH 7.4，5 mM MgCla> 0.2®1中加入人血小板膜區分（O.ling)及5 nM[3H] PGDa(115 Ci/mffl〇l)，於41C下反應90分鐘。反應後使用玻璃纖維濾 紙過濾，以冷生理食鹽水洗淨數次，测定殘餘在濾紙之放 射活性。特異性結合量係從全結合量減去非特異性結合量 (10 PGD2#在下之結合量）之值。各化合物之結合阻 礙活性係Μ在化合物非存在下之結合量作為100%，求取 各化合物存在下之結合量（％)而作成取代曲線，算出50% 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 234 513422 A7 B7 五、發明説明（231 ) 抑制濃度（I CeD值）。結果表示於下。 化合物编號結合活性UM>化合物编號結合活性UM) 3a - 4 0.6 2a-4 0.54 la-115 8.6 2a -17 0.12 la-28 0.045 2a - 21 5.2 la - 47 0.0086 2a-28 0.046 la-100 0.56 2a-95 1.6 la-176 0.047 2a-109 0.003 la-2 0.13 1 a-162 0.027 (請先閲讀背面之注意事項再 -- 本頁) 經濟部中央標準局員工消費合作社印製 實驗例2 使用人血小板之PGDa受容體的拮抗活性 Μ預先添加有1/9之檸樺酸一右旋糖液的注射器從健 康正常人採取末梢血液，以180g離心10分鐘後，採取上清 (PRP : Platelet roch plasma)。Μ洗淨緩衝液將所得到 之PRP離心洗淨3次後，Mmicrocell計數器計數血小板數 目。將調製成最終濃度5X 10e®/ml之血小板浮游液加溫 至37它後，M3-異丁基-1甲基黃瞟呤（0.5bM)前處理5分 鐘，添加稀釋成各種濃度之化合物，10分鐘後，添加0.1 〜2·0ίΐΜ之PGDa而引起反應。15分鐘後加入鹽酸Μ停止反 應，Μ超音波homogenizer破壊血小板，離心後Μ放射分 析定量其上清中之CAMP。藥物之PGDa受容體拮抗活性係Κ 各濃度求取對於藉PGDa添加而增加之CAMP的抑制率，算出顯 示50%阻礙之藥物濃度而進行評價。結果表示於下。 訂 本紙浪尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 235 513422 A7 B7 五、發明説明（232 化合物编號 人血小板cAMP上昇阻礙IC^UM) 3a-16 0.37 la-121 2.11 la-28 0.30 la - 47 2.09 2a - 2 0.77 2a-4 0.94 2a-35 1.52 2a-75 0.71 (請先閲讀背面之注意事項本頁) 經濟部中央標準局員工消費合作社印製 實驗例3 鼻塞模型之實驗 使用天竺鼠之鼻腔抵抗之測定及抗鼻塞作用之評價方 法表示於Μ下。以超音波嗅霧器將1%卵白清蛋白（OVA)溶 液煙霧化，使此令Hartley条雄性天竺鼠每隔一遇Μ 2次 各吸入10分鐘而作用之，其7日後，暴露抗原而引起反應 。戊巴比妥（30 ag/kg，i.p.)麻醉下切開天竺鼠的氣管而 分別於鼻腔俩與肺侧裝載揷管，於肺側連接一可Μ每分鐘 60次、1次4ml之空氣的人工呼吸器。Μ加拉明（gallamine) (2 mg/kg，i.v.)使天竺鼠之自發呼吸停止後，從鼻腔侧 之插管使用人工呼吸器將每分70次、1次4ml之空氣送至鼻 吻側，介由裝載於側枝之轉換器Μ測定此送氣中必要的空 氣壓，作爲彝腔抵抗的指標。抗原的暴露係藉由於人工呼 吸器與鼻腔揷管之間使3% 0VA溶液的煙霧劑產生3分鐘 來進行的。被檢藥物乃於抗原暴露的10分鐘前靜脈注射。 成績係連績测定0至30分鐘間之鼻腔抵抗，其分鐘間之 AUC〔縱軸為鼻腔抵抗（caHa〇>、横軸為時間（0-30分鐘）〕 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 236 513422 A7 B7 五、發明説明（233 當為指檫，表示成對於媒液之抑制率。結果表示於Μ下 化合物纗號 抑制率（％> lng/Kg(i.v J 備 考 3ag/Kg(i.v.) 10ag(Kg(p.ο.) l〇eg(Kg(p.ο.) 製劑例1 經濟部中央標準局員工消費合作社印製 la - 28 44 la-98 69 la-100 50 la-115 66 la-116 48 la-120 58 la-2 82 la-162 80 la-176 60 la-267 62 2a - 4 60 2a-21 52 2a-28 54 2a-95 77 2a-96 77 2a-109 73 2a-110 66 2a-194 79 (請先閱讀背面之注意事項本頁) 錠劑之製造 依常用的方法製造一含有40 ng之有效成分的錠劑 40 mg錠的組成表示於下。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 237 513422 A7 B7 234 五、發明説明（ ( + )-(Z)-7-[(lR，2S,3S，4S)-3 -苯磺醯胺雙環[2,2,1]庚-2 - 基]-5-庚烯酸鈣二水和物 40.0 mg 羥丙基纖維素 3.6 mg 硬脂酸鎂 0.4 mg 玉蜀黍澱粉 18.0 mg 乳糖 58.0 mg 合計 120.0 mg 製劑例2 顆粒劑之製造 (+)-(Z)-7-[(lR,2S,3S,4S)-3 -苯磺醯胺雙環[2,2,1]庚-2- 經濟部中央標準局員工消費合作社印製 基]-5-庚烯酸鈣二水和物 100. .0 mg 羥丙基纖維素 30. ,0 mg 羧甲基纖維素鈣 30. ,0 mg 滑石粉 10. ,0 mg 聚氧伸乙基（160)聚氧伸丙基（30> 乙二醇188 20. 0 ag 結晶纖維素 70. 0 mg 玉蜀黍澱粉 300. 0 mg 乳糖 440. 0 mg 合計 1000.0 mg 238 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 513422 補充說明書 (一） 申請案號數：第八五一〇七四二五號 (二） 申請案名稱：雙環之環系胺基衍生物及含有該衍生物之？〇〇2拮 抗劑組成物 (三） 申請人姓名：曰商•鹽野義製藥股份有限公司 地址：日本 代理人姓名：憚軼群技師(M100046301，台代字第487號） 康偉言技師(A104293682,台代字第1501號） 地址：台北市松山區105南京東路三段2 4 8號七樓 (四） 補充之依據·· 87.09.11·台專(玖)02021字第131515號函 收文日期：中華民國87年09月14曰
(五) 補充要點··依原已揭示之内容，補充具有r<DY f^Y結構 經濟部中央標準局員工消費合作社印製 之化合物的物理化學數據，及使用人體血小板 之PGD2受容體的拮抗活性（IC50)。 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 513422 (六）補充内容：
COOH
COOH
S
經濟部中央標準局員工消費合作社印製 Ή-NMR及其他數據 1 1.20-2.40 (13H, m)r 3.01 (1H, m), 4.07 (1H, d, J =： 4.0 Hz), 4.41 (1H, tf J = 5.0 Hz), 5.16 (2H, m), 5.64 (1H, d, J = 6.0 Hz), 7.5δ (3H, m), 7.88 (2H, m). IR(film): 3206, 1706, 1157 cm*1 2 0.87 and 1.24 (each 3H, each s), L51 (1H, d, J = 10.5 Hz), L60-2.61 (14¾ m), 4.24 (1H, m), 5.32-5.45 (2H, m), 6.12 (1H, d, J = 9.0 Hz), 7.37-7.48 (2H, m), 7.85-7.88 (2H, m), 8.33 (1H, d, J = 7.8 Hz). IR (CHCla)： 3429, 3067, 3023, 3014, 2923, 2871, 1708, 1652, 1556, 1516, 1494(:1^4:^25-23.0° (c=1.00%，CH3OH) 3 1.11 and 1.24 (each 3H, each s), 1.50 (1H, d, J = 10.8 Hz), 1.59^2.60 (14H, m), 4.20 (1H, m), 5.32-5.45 (2H, m), e.09 (1H, d, J = 8.4 Hz), 7.16 (1H, ddd, J = 2.4, 9.0 and 10.2 Hz), 7.77 (1H, dd, J = 4.8 and 9.0 Hz), 7.93 (1H, s), 8.09 (1H, dd, J = 2.4 and 0.2 Hz). IR (CHCls)： 3429, 3095, 3030, 3015, 2923, 2871, 1708, 1653, 1603, 1566, 1517, 1432 cm*1 [α]〇23-22.4° (c=1.〇1%,CH3OH) 一 2- 本紙張尺度適用中國國家標準（CNS ) a4規格（210X297公釐） 513422 0.86 and 1.23 (each 3Hr each s), 1.49^2.58 (15H, m), 4.24 (1H, m), 5.25-5.40 (2H, m), 6.18 (1H, d, J = 9·0Ηζ), 7.03 (1H, dd, J = 2.4 and 8.7 Hz), 7.66 (1H, d, J = 8.7 Hz), 7.77 (1H, s), 8.06 (1H, d, J = 2.4 Hz). IR(CHC13): 3425, 3237, 3029, 3021, 3017, 2924, 2871，1707, 1637, 1519, 1457, 1437 cm*1 [α]〇25-18.7° (c=1.00%, CH3OH) 5 0.91 (1H, d, J = 10.2 Hz), 1.13 and 1.25 (each 3H, each s), 1.60-1.88 (3H, m)F 2.01- 2.50 (10H, m), 2.79 (1H, t, J = 11.6Hz), 4.54 (1H, m), 5.31- 5.50 (2H, m), 6.10 (1H, d, J = 8.4 Hz), 7.37-7.48 (2H, m), 7.85-7.88 (2H, m), 8.33 <1H, d, J = 7.5 Hz). IIUCHCla): 3429, 3065, 3023, 3015, 2923, 2872, 1708, 1651, 1556, 1516, 1493 cm'1 [α]ϋ25+26.5° (c=1.01%f CHsOH) 6 0.91 (1H, d, J = 10.2 Hz), 1.12 and 1.25 (each 3H, each s), 1.60-1.90 (3H, m), 2.01-2.50 (10H, m), 2.78 (1H, t, J = 12.2 Hz), 4.52 (1H, m), 5.30-5.50 (2H, m), 6.08 (1H, d, J = 8.4 Hz), 7.16 (1H, dt, J = 2.7 and 8.7 Hz), 7.77 (1H, dd, J = 4.5 and 8.7 Hz), 7.91 (1H, s), 8.09 (1H, dd, J = 2.7 and 9.9 Hz). IR(CHCls): 3430, 3095, 3024, 3015, 2923, 2872, 1708,1652, 1603, 1565, 1517, 1433 cm1 [a]D25+25.8° (c=1.00%, CH3OH) 7 0.88 (1H, d, J = 9.9 Hz), 1.11 and 1.26 (each 3H, each s), 1.50-1.90 (3H, m), 2.00-2.23 (8H, m), 2.40-2.50 (2H, m), 2.83 (1H, t, J = 12.0 Hz), 4.55 (1H, m), 5.24-5.44 (2H, m), 6.11 (1H, d, J = 9.0 Hz), 7.02 (1H, dd, J = 2.4 and 8.4 Hz), 7.67 (1H, d, J = 8.4 Hz), 7.75 (1H, s), 8.12 (1H, d, J = 2.4 Hz). IR(CHCl3)： 3425, 3222, 3028, 3022, 3015, 2923, 2872, 1707, 1637, 1601, 1519, 1456, 1437 0^((^25+19.3° (c=1.00%, CH3OH) 請 先 閲 讀 背 φ 之 注 意 事 項 再 .装 訂 經濟部中夬榡準局員工消費合作衽印製 使用人體血小板之PGD2受容體的拮抗活性（IC5。） 化合物編號 β Μ 化合物編號 β Μ 1 *(7.1%) 5 0.37 2 0.77 6 0.037 3 0.58 7 0.23 4 0.29 10 Μ Μ時69抑制率 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 513422 補足說明 3
5
4 O-NMR and other data 1 1.20-2.40 (13H, m), 3.01 (1H, m), 4.07 (1H, d, J = 4.0 Hz), 4.41 (1H, t, J = 5.0 Hz), 5.16 (2H, m), 5.64 (1H, d, J = 6.0 Hz), 7.55 (3H, m), 7.88 (2H, m). IR(film): 3206, 1706, 1157 cm·1 2 0.87 and 1.24 (each 3H, each s), 1.51 (1H, d, J = 10.5 Hz), 1.60-2.61 (14H, m), 4.24 (1H, m), 5.32-5.45 (2H, m), 6.12 (1H, d, J = 9.0 Hz), 7.37-7.48 (2H, m), 7.85-7.88 (2H, m), 8.33 (1H，d, J = 7.8 Hz)· IR (CHC13): 3429, 3067, 3023, 3014, 2923, 2871, 1708, 1652, 1556, 1516, 1494 0^4^25-23.0° (c=1.00%，CH3OH) 3 1.11 and 1.24 (each 3H, each s), 1.50 (1H, d, J = 10.8 Hz), 1.59-2.60 (14H, m), 4.20 (1H, m), 5.32-5.45 (2H, m), 6.09 (1H, d, J = 8.4 Hz), 7.16 (1H, ddd, J = 2.4, 9.0 and 10.2 Hz), 7.77 (1H, dd, J = 4.8 and 9.0 Hz), 7.93 (lH, s), 8.09 (1H, dd, J = 2.4 and 0.2 Hz). IR (CHCls): 3429, 3095, 3030, 3015, 2923, 2871, 1708, 1653, 1603, 1566, 1517, 1432 cm*1 [a]D25.22.4° (c=1.01%，CH3OH) 513422 4 0.86 and 1.23 (each 3H, each s), 1.49-2.58 (15H, m), 4.24 (1H, m), 5.25-5.40 (2H, m), 6.18 (1H, d, J = 9.0Hz), 7.03 (1H, dd, J = 2.4 and 8.7 Hz), 7.66 (1H, d, J = 8.7 Hz), 7.77 (1H, s), 8.06 (1H, d, J = 2.4 Hz). IR(CHC13): 3425, 3237, 3029, 3021, 3017, 2924, 2871, 1707, 1637, 1519, 1457, 1437 0111^^10^-18.7° (c=1.00%, CHsOH) 5
0.91 (1H, d, J = 10.2 Hz), 1.13 and 1.25 (each 3H, each s), 1.60-1.88 (3H, m), 2.01- 2.50 (10H, m), 2.79 (1H, t, J = 11.6Hz), 4.54 (1H, m), 5.31- 5.50 (2H, m), 6.10 (1H, d, J = 8.4 Hz), 7.37-7.48 (2H, m), 7.85-7.88 (2H, m), 8.33 (1H, d, J = 7.5 Hz). IR(CHC13)： 3429, 3065, 3023, 3015, 2923, 2872, 1708, 1651, 1556, 1516, 1493 cm*1 [^]d25+26.5〇 '(c=1.01°/〇, CHsOH). 6 0.91 (1H, d, J = 10.2 Hz), 1.12 and 1.25 (each 3H, each s), 1.60-1.90 (3H, m), 2.01-2.50 (10H, m), 2.78 (1H, t, J = 12.2 Hz), 4.52 (1H, m), 5.30-5.50 (2H, m), 6.08 (1H, d, J = 8.4 Hz), 7.16 (1H, dt, J = 2.7 and 8.7 Hz), 7.77 (1H, dd, J = 4.5 and 8.7 Hz), 7.91 (1H, s), 8.09 (1H, dd, J = 2.7 and 9.9 Hz). IR(CHCl3): 3430, 3095, 3024, 3015, 2923, 2872, 1708, 1652, 1603, 1565, 1517, 1433 cm*1 [a]D25+25.8° (c=1.00°/〇, CHsOH) 7 . 0.88 (1H, d, J = 9.9 Hz), 1.11 and 1.26 (each 3H, each s), 1.50-1.90 (3H, m), 2.00-2.23 (8H, m), 2.40-2.50 (2H, m), 2.83 (1H, t, J = 12.0 Hz), 4.55 (1H, m), 5.24-5.44 (2H, m), 6.11 (1H, d, J = 9.0 Hz), 7.02 (1H, dd, J = 2.4 and 8.4 Hz), 7.67 (1H, d, J = 8.4 Hz), 7.75 (1H, s), 8.12 (1H, d, J = 2.4 Hz). IR(CHC13): 3425, 3222, 3028, 3022, 3015, 2923, 2872, 1707, 1637, 1601, 1519, 1456, 1437 cm*1 [a]D25+19.3° (c=1.00%, CHsOH)
匕卜血小板奁使〇 PGD2受容体®拮抗活性（IC50)
Compound No H Μ Compound No PL M 1 *(7.1%) 5 0.37 2 0.77 6 0.037 3 0.58 7 0.23 4 0.29 * 10 Μ Μ時©抑制率 以上 一2— 513422 資料1 la-2 1&·3 la-14 la-15 la-20 la-21 la-143 la-144 la· 145 la-155 la. 157 la· 158 la-159 la-160 la>171 la-172 la-173 la-174 la-184 la-188 la-189 la· 190 la-191 2flt-32 2a-33 2a>54 2a-55 2a-58 2a-59 2a-61 2a-63 実験例1 (MM) 0·13 0.03 1-2 0.4 0,76 0.6 実験例2 (江Μ) 0.08 0.18 実験例3 (%) 82 75 38 0.25 0.10 0.18 0.79 0.18 >1 0.46 0.18 6.0 0.55 5.9 >10 >10 3.8 1·50.6 7.5 10> 7.2 3·3 0·22 0.38 >1 >1 >1 513422 2a-67 0.0089 2a-69 0.0089 2a-89 1.4 2a-91 0.4 0.466 2a-93 2.0 0.22 38 2a-95 0·13 0.224 77 ' 2a-103 >10 >1 2a-139 0.015 0.29 16 2a-150 >1 2a-151 >1 2a-152 >1 2a-154 0.38 2a-156 >1 2a-170 0.0013 0.39 2a-171 0.024 0.24 2a-172 1.98 2a-174 0.28 2a-184 0.39 2a· 185 0.032 0.22 2a-186 >1 2a-188 0.032 0.064 34 2a-189 0.057 9 2a-190 26 2a-191 0.1 2a-192 0.026 2a· 198 0.18 2a-199 0.47 2a-200 0.50 2a-201 0.63 2a-206 0.082 2a-207 0.21 2a-274 0.44 2a-275 0.24 2a-278 0.219 2a-279 0.259 2a-282 0.47 2a-283 0.65
2 513422 SL 27
補充資料：自化合物「3d-l’」製備「3d:l」的方法 將取自於中文說明書第28頁實施例3所製備之化 合物3d_l’（（2)-7-[(1以，23,33,43)-3-笨基磺醯基胺基雙 %[2,2，1]庚-2-基]-5_庚稀酸：1弓）依下述方法製備其水合 物一化合物3d-1。 (中文版） 於化合物（3d-Γ)(4.49克，11.9毫莫耳）中添加水（25毫升） 及1當量之氫氧化鈉水溶液（11.9毫升）。於所得之水溶液 中，在室溫下添加CaCl2(1.32克，11.9毫莫耳）溶於水（50毫 升）的溶液。將反應溶液攪拌6小時，濾取生成的結晶。將 所得之結晶以水清洗，得到4.68克（94.9%)化合物（3d-1)， 為無色枉狀結晶。 (曰文版） 「化合物（3d —Γ ) (4.4 9g, 1 l/9mmol)丨C水（2 5ml)及VI規定水酸化 于卜y々厶水溶液（1 1 · 9 mL) ξ:加;水溶液1C、室通TCC a C 1 2 (1· 3 2g、ll.9mmol) S:、水（5 0mL){C溶加ΙΛ:水溶液ί:加文反応液 6時間携拌匕、生匕Λ：結晶奁5取結晶《:水T洗浄U 4. 68g (9 4· 9%) (〇化合物（3d — 1)奁無色柱状結晶tLT得Λ：β J 經濟部中央標準局貝工消費合作社印製 本紙張尺度適用中國國家棣準（CNS ) A4規格（210 X 297公釐）

Claims (1)

  1. 3 IX 5
    公 ABCD 六、申請專利範圍 第8篇425號專利申請案申請專利範圍修正本的年9月27日 1. -種用以料前列腺B2(PGD2)结抗劑之醫藥組成物 ，其係含有一以式（I)
    表示的雙環之環系胺基衍生物或其鹽亦或水合物作為有 效成分；（上述式中， 0 乃表示 A 為 -CH2-CH = CH-(CH2)3- 、 -ch2-ch=ch-(ch2)2-c(ch3)2- 、_ch2-c(=o)-(ch2)4-、 -CH=CH-(CH2)3-、c广c9烷撐基； 、一心一crv一 B為氫、Ci〜C6烷基、CrQ烷基苯基； R為 COORi、CH2OR2 或 CON(R3)R4 ; R1為氫或Cl〜C6烷基； R2為氮； 尺3及R4分別為氫、羥基或CpCs烷基磺醯基； 本紙張尺度適用中國國家標準（CNS) A4規格（210X297公釐） -239- 513422 Λ BCD ^、申請專利範圍 Χι為單鍵、苯樓基、嚷吩二基、吲哚二基或嘮唾二 基； Χ2為單鍵、-Ν=Ν-、-N=CH-、-CH=N-N-、-(Ι；Η=Ν-〇-、 -CH=CH_、-CH=(OH)-、-C(C1)=C(C1)-、-(CH2)n、-Ce C-、 -N(R5)-、-N(R51)CO-、-N(R53)CON(R54)-、-CON(R55)-、 ·0-、-S-、-SO-、-S02-、-CO-、-CH20-、秦吐二基，、 或四嗤二基； Χ3為烷基、c2〜c6烯基、苯基、萘基、菲基、 芴基、Ci〜C6烧基笨基、二苯并吱喃基、σ塞吩基、味唾基、 苯并σ塞吩基、盼三σ秦基、苯并噚ϋ坐基、二苯并噚σ比基、 嗎啉基、四唑基、咄啶基、呋喃基、噚唑基、。无烯基、 二羥噚二唑基、苯并間二氧雜還戊烯基、吲哚基、噻嗤 基、苯甲醯、苯并咪唑基、噻二唑基、異噻唑基、吼α各 基、四氫苯噻吩基（==環己噻吩基）、二苯并噻吼基、二氫 苯并噻吼基、仙基、二苯并二羥喹啉基、二苯并噻吩基、 C3〜Cs環烧基、C3〜Cg環婦基、亞σ塞唾琳基甲基、亞嘆嗤 啉基曱基、-CH=NR6、-N=C(R7)R8 ; R5、R51、R53、R54及 R55 為氫； r6為羥基、脲基、以苯基取代之脲基、硫脲基、以 笨基取代之硫脲基； R7&R8分別為苯基； η為1或2 ; Ζ為-S〇2-或-C0-， m為0或1 ; 本紙張尺度適用中國國家標準（CMS) A4規格（210X297公釐） -240- 513422 A B c D 六、申請專利範圍 於此等定義中，取代基為硝基、（^〜(^烷氧基、氨磺 醯基、胺基、以Cl〜C6烧基取之胺基、Cl〜C6烧基經基、 甲醯基、烧基羥基氧基、羥基、鹵素、（^〜(：6院基、 C2〜C：6炔基、羰基、（^〜(：6烧基氧基羰基、甲續酿氧基、 氰基、C2〜C6烯氧基、三氟甲基、（^〜(^烧硫基、-N=PPh3、 氧基、硫基、苯基、以氰基取代之苯基。 2·如申請專利範圍第1項之用以作為前列腺素D2(Pgd2^ 抗劑之醫藥組成物，於有效成分以式（I)所示的雙環之環 系胺基衍生物中， 0 乃表示 α m為0、Ζ為S〇2時，Χ^Χ2均為單鍵，χ3表示烷基、苯 基、萘基、苯乙烯基、喹啉基或噻吩甲基，此等之取代 基中，環狀者亦可被選自硝基、烷氧基、取代或非取代 胺基、_素、烷基及羥烷基中之1〜3個基所取代的雙環 之環系胺基衍生物或其鹽亦或水合物。 3·如申請專利範圍第i項之用以作為前列腺素〇2(1>(}£)2)括 抗劑之醫藥組成物，於有效成分為以式⑴所示的雙環之 環系胺基衍生物中，
    -241- 513422
    六、申請專利範圍 乃表不 α m為1時，Xi&X2均為單鍵，&為亦可被鹵素所取代之 苯基的雙環之環系胺基衍生物或其鹽亦或水合物。 4·如申請專利範圍第丨項之用以作為前列腺素D^pGD2)拮 抗劑之醫藥組成物，於有效成分乃以式⑴所示的雙環之 環系胺基衍生物中， · Q 乃表示 α m為1時’义丨為亞苯基，Xa-CH2-或-Ν=Ν· , &為苯基 的雙環之環系胺基衍生物或其鹽或水合物。 5·如申請專利範圍第1項之用以作為前列腺素D2(PGD2)拮 抗劑之醫藥組成物，係治療鼻塞之醫藥組成物。 6· —種雙環之環系胺基衍生物或其鹽或水合物，係以式 (la)所示，
    B (式中’a'b'r'x!、χ2&χ3乃與申請專利範圍第i 項之定義相同； 、申請專利範圍 但，（1瓜為單鍵、X2為單鍵、x^Ci〜C6烧基、取 代或非取代苯基或萘基； (2) X々單鍵、X2為-(CH2)n或-CH2CH2-、 炫基或芳基； (3) Χι為笨樓基、X2為單鍵、烧基； (4) Χ!為單鍵、X2為單鍵、&為σ比咬基時除外）。 7·如申請專利範圍第6項的雙環之環系胺基衍生物或其鹽 或水合物，Xi&X2為單鍵，X3為異噚唑基、噻嗔嗤基 、異噻唑基、嗎啉基、吲哚基、苯并呋喃基、二笨并呋 喃基、一本并二氧基、笨并σ塞吩基、二苯并11 塞吩基、吟 唑基、氧雜蒽基、酚三嗪基、二笨并哼σ比基、二苯并噻 0比基、二氮雜萘基、氧萘基、苯并咪唑基或二氫苯并噻 吡基、A、Β、R之定義同於申請專利範圍第1項。 8·如申請專利範圍第6項的雙環之環系胺基衍生物或其鹽 或水合物，义！為單鍵，X2為亞苯基、χ3為烯基、炔基 、-CH=NRA-N=C(R7)R8，a、Β、R、R6、rar8 乃與 申請專利範圍第1項之定義相同。 9·如申請專利範圍第6項的雙環之環系胺基衍生物或其鹽 或水合物，R表示COOR，乂1表示亞苯基或噻吩二基， x2表示單鍵、-N=N-、-CH=CH-、-CONH-、-NHCO-或 亞乙烯基，X3表示苯基、噻唑烷基甲基、噻唑嘻烷基甲 基或噻吩基，A、B、R!、R6、R7&r8乃與申請專利範 圍第1項之定義相同。 10· —種雙環之環系胺基衍生物或其鹽或水合物，係以式 513422 AB c D 六、申請專利範圍 (lb):
    係表示 CC 或 φ( A、B、R、Xi、X2及X3乃與申請專利範圍第1項之定義 相同；但，Xi&X2為單鍵，Xs為苯基時除外）所示。 11·如申請專利範圍第10項的雙環之環系胺基衍生物或其 鹽或水合物，於式（lb)所示之化合物中， 0 乃表不 α A、Β、R、X!、X2及X3乃與申請專利範圍第1項之定義 相同。 12·如申請專利範圍第11項的雙環之環系胺基衍生物或其 鹽或水合物，R為COORJRi乃與申請專利範圍第1項之 定義相同）。 本紙張尺度適用中國國家標準（CNS) A4規格（210X297公釐） -244- 513422 A B c D 六、申請專利範圍 13.如申請專利範圍第u項的雙環之環系胺基衍生物或其 鹽或水合物，X!為亞苯基或噻吩二基，χ2為單鍵、-N=N_ 、-CH-CH-，1，2-亞乙烯基、-〇-、-S-、-CO-、-CON(R55)-(R55乃與申請專利範圍第1項之定義相同）或 (RS1乃與申請專利範圍第丨項之定義相同） 及X3為苯基或σ塞吩基。 14·如申請專利範圍第1〇項的雙環之環系胺基衍生物或其 鹽或水合物，於式（lb)所示之化合物中， Q 乃表示 ¢( A、B、R、Xi、X2及X3乃與申請專利範圍第i項之定義 相同。 15. 如申請專利範圍第14項的雙環之環系胺基衍生物或其 鹽或水合物，B為氫，Xt&X2均為單鍵，χ3為噻吩甲基 、噻唑基、噻嗪唑基、異噻唑基、σ比咯基、σ比啶基、苯 并呋喃基、苯并咪唑基、苯并噻吩基、二苯并呋喃基、 二苯并噻吩基、喹啉基或吲哚基。 16. 如申請專利範圍第14項的雙環之環系胺基衍生物或其 鹽或水合物，Xi為亞苯基、噻吩二基、吲哚二基或哼唑 二基、X2為單鍵、-N=N-、-CH=CH-、1,2-亞乙烯基、 -S-、或- 0-、及X3為芳基或雜環。 本紙張尺度適用中國國家標準（CNS) A4規格（210X297公釐） -245- 8 8 8 8 A B c D 六、申請專利範圍 17.如申請專利範圍第1〇項的雙環之環系胺基衍生物或其 鹽或水合物，於式（lb)所示之化合物中， 0’ 乃表示 A為亦可具有氧基或不飽和鍵之烷撐基，b為氫，r為 CH2〇H或COOH，XAX2為單鍵，X3為取代或非取代之 本弁°塞吩基。 18· —種用以作為前列腺素D2(Pgd2)拮抗劑之醫藥組成物 ’其係含有申請專利範圍第6至17項中所載之化合物。 本紙張尺度適用中國國家標準（CNS) A4規格（210X297公釐） -246-
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