|
EP0903341A1
(en)
|
1997-07-22 |
1999-03-24 |
Akzo Nobel N.V. |
"Novel ortho-mercaptoaniline compounds"
|
|
US20020119443A1
(en)
|
2000-07-21 |
2002-08-29 |
Gilead Sciences, Inc. |
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
|
|
JP2006523669A
(ja)
*
|
2003-03-10 |
2006-10-19 |
ファイザー・インク |
Nima調節タンパク質(pin1)を阻害するための、リン酸/硫酸エステル化合物および医薬組成物
|
|
EA014685B1
(ru)
|
2003-04-25 |
2010-12-30 |
Джилид Сайэнс, Инк. |
Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
|
|
AU2005330489B2
(en)
|
2004-07-27 |
2011-08-25 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates as anti HIV agents
|
|
TW201402124A
(zh)
|
2005-08-19 |
2014-01-16 |
Array Biopharma Inc |
作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯
|
|
CA2691444C
(en)
|
2007-06-29 |
2016-06-14 |
Gilead Sciences, Inc. |
Purine derivatives and their use as modulators of toll-like receptor 7
|
|
EA019259B1
(ru)
|
2007-11-16 |
2014-02-28 |
Джилид Сайенсиз, Инк. |
Ингибиторы репликации вируса иммунодефицита человека
|
|
JP5465720B2
(ja)
|
2008-07-08 |
2014-04-09 |
インサイト・コーポレイション |
インドールアミン2,3−ジオキシゲナーゼの阻害剤としての1,2,5−オキサジアゾール
|
|
WO2010014913A1
(en)
|
2008-08-01 |
2010-02-04 |
Ventirx Pharmaceuticals, Inc. |
Toll-like receptor agonist formulations and their use
|
|
RS53347B
(sr)
|
2008-12-09 |
2014-10-31 |
Gilead Sciences, Inc. |
Modulatori toll-sličnih receptora
|
|
JP5690286B2
(ja)
*
|
2009-03-04 |
2015-03-25 |
イデニク プハルマセウティカルス,インコーポレイテッド |
ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
CN105669553A
(zh)
|
2009-08-18 |
2016-06-15 |
文蒂雷克斯药品公司 |
作为toll样受体调节剂的取代的苯并氮杂*
|
|
RU2016108987A
(ru)
|
2009-08-18 |
2018-11-26 |
Вентиркс Фармасьютикалз, Инк. |
Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
|
|
JP5694345B2
(ja)
|
2009-10-22 |
2015-04-01 |
ギリアード サイエンシーズ, インコーポレイテッド |
Toll様受容体の調節因子
|
|
WO2011106106A2
(en)
|
2010-02-24 |
2011-09-01 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
|
|
WO2011139637A1
(en)
|
2010-05-03 |
2011-11-10 |
Philadelphia Health & Education Corporation |
Small-molecule modulators of hiv-1 capsid stability and methods thereof
|
|
TWI500617B
(zh)
|
2010-05-31 |
2015-09-21 |
Ono Pharmaceutical Co |
Purine ketone derivatives
|
|
US20120149708A1
(en)
|
2010-06-17 |
2012-06-14 |
George Mason University |
Modulators of viral transcription, and methods and compositions therewith
|
|
MX2012015097A
(es)
|
2010-07-02 |
2013-05-28 |
Gilead Sciences Inc |
Derivados de acido naft-2-ilacetico para tratar sida.
|
|
EP2588455B1
(en)
|
2010-07-02 |
2018-04-04 |
Gilead Sciences, Inc. |
2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
|
|
JP6272695B2
(ja)
|
2010-09-01 |
2018-01-31 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
体重管理のために有用な5−ht2cアゴニストの改変放出剤形
|
|
US9102668B2
(en)
|
2010-09-08 |
2015-08-11 |
Glaxo Group Limited |
Polymorphs and salts
|
|
RS54286B1
(sr)
|
2010-09-08 |
2016-02-29 |
Glaxosmithkline Intellectual Property Development Limited |
Polimorfi i soli n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4-morfolinil]metil}-1,3-oksazol-2-il)-1h-indazol-6-il]-2(metiloksi)-3-piridinil]-metansulfonamida
|
|
EP3195868A3
(en)
|
2010-10-01 |
2017-08-02 |
VentiRx Pharmaceuticals, Inc. |
Therapeutic use of a tlr agonist and combination therapy
|
|
CN103237549A
(zh)
|
2010-10-01 |
2013-08-07 |
帆德制药股份有限公司 |
过敏性疾病的治疗方法
|
|
PY1153144A
(es)
|
2010-12-10 |
2015-01-01 |
Gilead Sciences Inc |
Inhibidores macrocíclicos de virus flaviviridae
|
|
EP3208263A1
(en)
|
2011-01-12 |
2017-08-23 |
VentiRx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
DK2663555T3
(en)
|
2011-01-12 |
2017-03-27 |
Ventirx Pharmaceuticals Inc |
SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS
|
|
JP5745102B2
(ja)
|
2011-02-12 |
2015-07-08 |
グローブイミューン,インコーポレイテッド |
慢性b型肝炎感染症のための酵母系免疫療法組成物
|
|
PT3590928T
(pt)
|
2011-04-08 |
2021-08-19 |
Janssen Sciences Ireland Unlimited Co |
Derivados de pirimidina para o tratamento de infeções virais
|
|
UA111841C2
(uk)
|
2011-04-21 |
2016-06-24 |
Гіліад Сайєнсіз, Інк. |
Сполуки бензотіазолу та їх фармацевтичне застосування
|
|
AU2012258220B2
(en)
|
2011-05-18 |
2017-01-19 |
Janssen Sciences Ireland Uc |
Quinazoline derivatives for the treatment of viral infections and further diseases
|
|
AU2012278976B2
(en)
|
2011-07-06 |
2017-05-11 |
Gilead Sciences, Inc. |
Compounds for the treatment of HIV
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
ES2608871T5
(es)
*
|
2011-08-16 |
2024-04-04 |
Gilead Sciences Inc |
Alafenamide hemifumarate de tenofovir
|
|
US9199997B2
(en)
|
2011-11-29 |
2015-12-01 |
Ono Pharmaceutical Co., Ltd. |
Purinone derivative hydrochloride
|
|
US9399645B2
(en)
|
2011-12-20 |
2016-07-26 |
Boehringer Ingelheim International Gmbh |
Inhibitors of HIV replication
|
|
BR112014015197A8
(pt)
|
2011-12-21 |
2017-06-13 |
Novira Therapeutics Inc |
agentes antivirais de hepatite b
|
|
EP3578563B1
(en)
*
|
2011-12-22 |
2021-04-14 |
Geron Corporation |
Guanine analogs as telomerase substrates and telomere length affectors
|
|
SG11201404743TA
(en)
|
2012-02-08 |
2014-09-26 |
Janssen R & D Ireland |
Piperidino-pyrimidine derivatives for the treatment of viral infections
|
|
US20130267517A1
(en)
|
2012-03-31 |
2013-10-10 |
Hoffmann-La Roche Inc. |
Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
ES2575398T3
(es)
|
2012-03-31 |
2016-06-28 |
F. Hoffmann-La Roche Ag |
4-Metil-dihidropirimidinas novedosas para el tratamiento y la profilaxis de la infección por el virus de la hepatitis B
|
|
UY34750A
(es)
|
2012-04-20 |
2013-11-29 |
Gilead Sciences Inc |
?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
|
|
BR112014030649A2
(pt)
|
2012-06-08 |
2017-06-27 |
Gilead Sciences Inc |
inibidores macrocíclicos da flaviviridae vírus
|
|
PT2861604T
(pt)
|
2012-06-08 |
2017-05-05 |
Gilead Sciences Inc |
Inibidores macrocíclicos de vírus flaviridae
|
|
AR091279A1
(es)
|
2012-06-08 |
2015-01-21 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
|
MX369417B
(es)
|
2012-08-10 |
2019-11-07 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina para el tratamiento de infecciones víricas y otras enfermedades.
|
|
KR102271574B1
(ko)
|
2012-08-28 |
2021-07-01 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도
|
|
EA026957B1
(ru)
|
2012-08-28 |
2017-06-30 |
Янссен Сайенсиз Айрлэнд Юси |
Конденсированные бициклические производные сульфамоила и их применение в качестве лекарственных препаратов для лечения гепатита b
|
|
CN103665043B
(zh)
|
2012-08-30 |
2017-11-10 |
江苏豪森药业集团有限公司 |
一种替诺福韦前药及其在医药上的应用
|
|
CA2881322A1
(en)
|
2012-09-10 |
2014-03-13 |
F. Hoffmann-La Roche Ag |
6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
DK2903968T3
(en)
|
2012-10-02 |
2017-01-30 |
Gilead Sciences Inc |
INHIBITORS OF HISTON DEMETHYLASES
|
|
DK2906563T3
(en)
|
2012-10-10 |
2018-06-06 |
Janssen Sciences Ireland Uc |
PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES
|
|
KR101268466B1
(ko)
|
2012-11-12 |
2013-06-04 |
유병수 |
사축형 윈드 터빈
|
|
EA035431B1
(ru)
|
2012-11-16 |
2020-06-15 |
Янссен Сайенсиз Айрлэнд Юси |
Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций
|
|
CA2894399A1
(en)
|
2012-12-06 |
2014-06-12 |
Quanticel Pharmaceuticals, Inc. |
Histone demethylase inhibitors
|
|
SMT201800070T1
(it)
|
2012-12-19 |
2018-03-08 |
Celgene Quanticel Res Inc |
Inibiorti di istone demetilasi
|
|
EA030003B1
(ru)
|
2012-12-21 |
2018-06-29 |
Джилид Сайэнс, Инк. |
Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
|
|
BR112015014968A2
(pt)
|
2012-12-21 |
2017-07-11 |
Quanticel Pharmaceuticals Inc |
inibidores de histona-desmetilase
|
|
PE20151063A1
(es)
|
2012-12-27 |
2015-08-03 |
Japan Tobacco Inc |
DERIVADO SUSTITUIDO DE ESPIROPIRIDO[1,2-a]PIRAZINA Y USO MEDICO DEL MISMO COMO INHIBIDOR DE LA INTEGRASA DEL VIH
|
|
SG11201506639XA
(en)
|
2013-02-21 |
2015-09-29 |
Janssen Sciences Ireland Uc |
2-aminopyrimidine derivatives for the treatment of viral infections
|
|
PE20151667A1
(es)
|
2013-02-27 |
2015-11-27 |
Epitherapeutics Aps |
Inhibidores de histona desmetilasas
|
|
WO2014131847A1
(en)
|
2013-02-28 |
2014-09-04 |
Janssen R&D Ireland |
Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
|
|
US9738637B2
(en)
|
2013-03-12 |
2017-08-22 |
Celgene Quantical Research, Inc. |
Histone demethylase inhibitors
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
KR20150130491A
(ko)
|
2013-03-13 |
2015-11-23 |
제넨테크, 인크. |
피라졸로 화합물 및 그것의 용도
|
|
EP2969007B1
(en)
|
2013-03-14 |
2019-05-08 |
Celgene Quanticel Research, Inc. |
Histone demethylase inhibitors
|
|
CA2903465A1
(en)
|
2013-03-15 |
2014-09-25 |
Quanticel Pharmaceuticals, Inc. |
Histone demethylase inhibitors
|
|
MX353412B
(es)
|
2013-04-03 |
2018-01-10 |
Janssen Sciences Ireland Uc |
Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
EP2986220B1
(en)
|
2013-04-15 |
2017-02-01 |
Becton, Dickinson and Company |
Biological fluid collection device and biological fluid collection and testing system
|
|
DK2997019T3
(en)
|
2013-05-17 |
2018-12-03 |
Janssen Sciences Ireland Uc |
SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
|
|
TWI733288B
(zh)
|
2013-05-17 |
2021-07-11 |
愛爾蘭商健生科學愛爾蘭無限公司 |
胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
|
|
BR112015028873A2
(pt)
|
2013-05-17 |
2017-07-25 |
Hoffmann La Roche |
heteroaril-diidro-pirimidinas interligados na posição 6, para o tratamento e profilaxia de infecção pelo vírus da hepatite b
|
|
EP3004121A1
(en)
|
2013-06-07 |
2016-04-13 |
Cipla Limited |
An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
|
|
WO2015002434A1
(en)
|
2013-07-03 |
2015-01-08 |
Dong-A St Co.,Ltd |
Novel tenofovir disoproxil salt and the preparation method thereof
|
|
HRP20180791T1
(hr)
|
2013-07-25 |
2018-09-07 |
Janssen Sciences Ireland Uc |
Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b
|
|
KR20150025993A
(ko)
|
2013-08-30 |
2015-03-11 |
동아에스티 주식회사 |
테노포비어 디소프록실 산부가염 및 이의 제조방법
|
|
SI3043865T1
(sl)
|
2013-09-11 |
2021-04-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Metode in farmacevtski sestavki za zdravljenje virusne okužbe s hepatitisom B
|
|
WO2015040640A2
(en)
|
2013-09-20 |
2015-03-26 |
Laurus Labs Private Limited |
An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof
|
|
CA2923712C
(en)
|
2013-10-23 |
2021-11-02 |
Janssen Sciences Ireland Uc |
Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
|
|
WO2015073774A1
(en)
|
2013-11-14 |
2015-05-21 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis b infections
|
|
WO2015107451A2
(en)
*
|
2014-01-14 |
2015-07-23 |
Mylan Laboratories Ltd. |
Purification of tenofovir alafenamide and its intermediates
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US9181288B2
(en)
|
2014-01-16 |
2015-11-10 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
EA201691261A1
(ru)
|
2014-01-30 |
2016-11-30 |
Ф. Хоффманн-Ля Рош Аг |
Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
|
|
TW201620893A
(zh)
|
2014-02-06 |
2016-06-16 |
健生科學愛爾蘭無限公司 |
磺醯胺基吡咯醯胺衍生物及其用作治療b型肝炎之醫藥品的用途
|
|
AU2015226206B2
(en)
|
2014-03-07 |
2017-03-16 |
F. Hoffmann-La Roche Ag |
Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
|
|
US9400280B2
(en)
|
2014-03-27 |
2016-07-26 |
Novira Therapeutics, Inc. |
Piperidine derivatives and methods of treating hepatitis B infections
|
|
FR3020810B1
(fr)
*
|
2014-05-06 |
2016-05-06 |
Servier Lab |
Nouveau sel de l'ivabradine et son procede de preparation.
|
|
KR20160148715A
(ko)
|
2014-05-13 |
2016-12-26 |
에프. 호프만-라 로슈 아게 |
B형 간염 바이러스 감염의 치료 또는 예방을 위한 신규한 다이하이드로퀴놀리진온
|
|
CN105085571A
(zh)
*
|
2014-05-20 |
2015-11-25 |
四川海思科制药有限公司 |
替诺福韦艾拉酚胺复合物及其制备方法和用途
|
|
RU2016149812A
(ru)
|
2014-06-06 |
2018-07-17 |
Флексус Байосайенсиз, Инк. |
Иммунорегулирующие средства
|
|
WO2016012470A1
(en)
|
2014-07-25 |
2016-01-28 |
F. Hoffmann-La Roche Ag |
New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
|
|
BR112017002970B1
(pt)
|
2014-08-14 |
2023-04-11 |
F. Hoffmann-La Roche Ag |
Novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
|
|
SG11201701182VA
(en)
|
2014-08-27 |
2017-03-30 |
Gilead Sciences Inc |
Compounds and methods for inhibiting histone demethylases
|
|
CN107912040B
(zh)
|
2014-10-10 |
2021-04-06 |
基因泰克公司 |
作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
UY36390A
(es)
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
US20160144461A1
(en)
*
|
2014-11-21 |
2016-05-26 |
Huntington Alloys Corporation |
Ni-Cr-Mo-Ta-Nb Welding Filler Metals, Welding Filler Metal Consumables, Weld Deposits, Methods of Making Weld Deposits, and Weldments Thereof
|
|
CN104558036A
(zh)
*
|
2014-12-11 |
2015-04-29 |
杭州和泽医药科技有限公司 |
一种替诺福韦艾拉酚胺半反丁烯二酸盐晶型及其制备方法
|
|
AR103222A1
(es)
|
2014-12-23 |
2017-04-26 |
Hoffmann La Roche |
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|
|
US9676793B2
(en)
|
2014-12-23 |
2017-06-13 |
Hoffmann-Laroche Inc. |
Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
|
|
CN107108610B
(zh)
|
2014-12-30 |
2019-06-04 |
豪夫迈·罗氏有限公司 |
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|
|
CN107109497A
(zh)
|
2014-12-31 |
2017-08-29 |
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|
|
MA41338B1
(fr)
|
2015-01-16 |
2019-07-31 |
Hoffmann La Roche |
Composés de pyrazine pour le traitement de maladies infectieuses
|
|
WO2016120186A1
(en)
|
2015-01-27 |
2016-08-04 |
F. Hoffmann-La Roche Ag |
Recombinant hbv cccdna, the method to generate thereof and the use thereof
|
|
HK1244281B
(zh)
|
2015-02-11 |
2020-02-07 |
F. Hoffmann-La Roche Ag |
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|
|
CZ2015384A3
(cs)
|
2015-06-05 |
2016-12-14 |
Zentiva, K.S. |
Pevné formy Tenofovir alafenamidu
|
|
EP4092037A1
(en)
*
|
2015-06-17 |
2022-11-23 |
Gilead Sciences, Inc. |
Co-crystals, salts and solid forms of tenofovir alafenamide
|
|
CA2921336A1
(en)
*
|
2015-06-30 |
2016-12-30 |
Gilead Sciences, Inc. |
Pharmaceutical formulations
|
|
TW202510891A
(zh)
|
2017-01-31 |
2025-03-16 |
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|