TW202426489A - 限制性條件性活化之結合蛋白 - Google Patents

限制性條件性活化之結合蛋白 Download PDF

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TW202426489A
TW202426489A TW112143878A TW112143878A TW202426489A TW 202426489 A TW202426489 A TW 202426489A TW 112143878 A TW112143878 A TW 112143878A TW 112143878 A TW112143878 A TW 112143878A TW 202426489 A TW202426489 A TW 202426489A
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查德 梅
羅伯特 杜布瑞基
瑪雅 維諾格拉多
阿南德 潘卡爾
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日商武田藥品工業股份有限公司
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Abstract

本發明係關於條件性雙特異性重導向活化構築體或COBRA，其以活性前驅藥格式來投予。在曝露於腫瘤蛋白酶後，使所述構築體進行裂解及活化以使得其可結合腫瘤靶抗原(TTA)以及CD3，因此將表現CD3之T細胞募集至腫瘤中，引起治療。

Description

限制性條件性活化之結合蛋白
本發明關於限制性條件性活化之結合蛋白的技術領域。
在各種臨床配置中通常需要選擇性破壞個別細胞或特異性細胞類型。舉例而言，癌症治療之主要目標為特異性地破壞腫瘤細胞，同時使健康細胞及組織儘可能地完整且不受損壞。一種此類方法為藉由誘導針對腫瘤之免疫反應以使諸如自然殺手(NK)細胞或細胞毒性T淋巴細胞(CTL)之免疫效應細胞攻擊且破壞腫瘤細胞。
為腫瘤相關抗原提供優異的結合特異性及親和力之完整的單株抗體(mAb)之使用已成功應用於癌症治療及診斷區域。然而，大量的完整mAb、其較差的生物分佈、低效力及血池中之長持久性限制了其臨床應用。舉例而言，完整抗體可在腫瘤區域內展現出特異性積聚。在生物分佈研究中，當精確研究腫瘤時，注意到在周邊區域中存在具有初級積聚之不均勻的抗體分佈。由於腫瘤壞死、不均勻的抗原分佈及增加的間質組織壓力，所以不可能到達具有完整的抗體構築體之腫瘤的中央部分。相反，較小的抗體片段顯示出快速的腫瘤定位，更深地滲透至腫瘤中，且亦自血流中相對快速地移除。然而，許多抗體包含scFv及其他構築體顯示出「中靶/脫靶腫瘤」效應，其中分子在非腫瘤細胞上具有活性，導致副作用，其中一些可能具有毒性。本發明涉及在腫瘤蛋白酶存在之情況下選擇性活化之新穎構築體。
本發明提供許多用於治療癌症之不同的蛋白質組合物。因此，在一個態樣中，本發明提供「格式2」蛋白質，其自N端至C端包括：結合至人類腫瘤靶抗原(TTA)之第一單結構域抗原結合結構域(sdABD)(sdABD-TTA)；b)第一結構域連接子；c)包括以下之限制性Fv結構域：i)包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域；ii)限制性不可裂解連接子(CNCL)；及iii)包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域；d)第二結構域連接子；e)第二sdABD-TTA；f)可裂解連接子(CL)；g)包括以下之限制性假Fv結構域：i)第一假輕可變結構域；ii)不可裂解連接子(NCL)；及iii)第一假重可變結構域；h)第三結構域連接子；及i)結合至人類血清白蛋白之第三sdABD；其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3；所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
在另一態樣中，本發明提供「格式1」蛋白質，其自N端至C端包括：a)第一sdABD-TTA；b)第一結構域連接子；c)包括以下之限制性Fv結構域：i)包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域；ii)限制性可裂解連接子(CCL)；及iii)包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域；d)第二結構域連接子；e)第二sdABD-TTA；f)可裂解連接子(CL)；g)包括以下之限制性假Fv結構域：i)第一假輕可變結構域；ii)不可裂解連接子(NCL)；及iii)第一假重可變結構域；h)第三結構域連接子；及i)結合至人類血清白蛋白之第三sdABD；其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且其中所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
在另一態樣中，本發明提供「格式4」蛋白質，其自N端至C端包括：a)結合至人類腫瘤靶抗原(TTA)之單結構域抗原結合結構域(sdABD)(sdABD-TTA)；b)第一結構域連接子；c)包括以下之限制性Fv結構域：i)包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域；ii)限制性不可裂解連接子(CNCL)；及iii)包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域；d)可裂解連接子(CL)；e)結合至人類血清白蛋白之第二sdABD；f)結構域連接子；g)包括以下之限制性假Fv結構域：i)第一假輕可變結構域；ii)不可裂解連接子(NCL)；及iii)第一假重可變結構域；其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且其中所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
在上面列出之格式1、格式2及格式4蛋白質之另一態樣中，所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
在上面列出之格式1、格式2及格式4蛋白質之另一態樣中，所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
在上面列出之格式1、格式2及格式4蛋白質之另一態樣中，所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
在上面列出之格式1、格式2及格式4蛋白質之另一態樣中，所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
在另一態樣中，本發明提供格式1及2蛋白質，其中所述第一及第二TTA為相同的。
在另一態樣中，本發明提供格式1及2蛋白質，其中所述第一及第二TTA為不同的。
在另一態樣中，本發明提供格式1、2及4蛋白質，其中所述第一及第二TTA選自EGFR、EpCAM、FOLR1及B7H3。此等序列可選自由以下組成之群：SEQ ID NO：1、SEQ ID NO：5、SEQ ID NO：9、SEQ ID NO：13、SEQ ID NO：17、SEQ ID NO：21、SEQ ID NO：25、SEQ ID NO：29；SEQ ID NO：33；SEQ ID NO：37及SEQ ID NO：41。
在另一態樣中，本發明提供格式1、2及4蛋白質，其中所述半衰期延長結構域具有SEQ ID NO：45。
在另一態樣中，本發明提供格式1、2及4蛋白質，其中所述可裂解連接子係藉由選自由以下組成之群之人類蛋白酶裂解：MMP2、MMP9、穿膜肽酶(Meprin) A、穿膜肽酶B、組織蛋白酶S、組織蛋白酶K、組織蛋白酶L、粒酶B、uPA、激肽釋放酶7、間質蛋白酶及凝血酶。
在另一態樣中，本發明提供選自由以下組成之群之蛋白質：Pro186、Pro225、Pro226、Pro233、Pro311、Pro312、Pro313、Pro495、Pro246、Pro254、Pro255、Pro256、Pro420、Pro421、Pro432、Pro479、Pro480、Pro187、Pro221、Pro222、Pro223、Pro224、Pro393、Pro394、Pro395、Pro396、Pro429、Pro430及Pro431。
在另一態樣中，本發明提供編碼如本文所描述之格式1、格式2或格式4蛋白質之核酸以及包括編碼所述蛋白質之核酸的表現載體及宿主細胞。
在另一態樣中，本發明提供製備本發明之蛋白質的方法及治療需要其之患者的方法。
在另一態樣中，本發明提供包括「格式3A」對前驅藥蛋白質之組合物，其包括：a)自N端至C端包括以下之第一蛋白質：i)第一sdABD-TTA；ii)第一結構域連接子；iii)自N端至C端包括以下之假Fv結構域：1)包括vhCDR1、vhCDR2及vhCDR3之可變重鏈；2)可裂解連接子；及3)包括iVLCDR1、iVLCDR2及iVLCDR3之第一假可變輕結構域；iv)第二結構域連接子；v) sdABD-HSA；a)自N端至C端包括以下之第一第二蛋白質：i)結合至人類腫瘤靶抗原之第三sdABD；ii)第三結構域連接子；iii)自N端至C端包括以下之假Fv結構域：1)包括VLCDR1、VLCDR2及VLCDR3之可變輕鏈；2)可裂解連接子；及3)包括iVHCDR1、iVHCDR2及iVHCDR3之第一假可變重結構域；iv)第四結構域連接子；v) sdABD-HSA；其中所述第一可變重結構域及所述第一可變輕結構域在締合時能夠結合人類CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子間締合以形成非活性Fv；其中所述第一可變輕結構域與所述第一假可變重結構域進行分子間締合以形成非活性Fv；且其中所述第一及第三sdABD選自由以下組成之群：SEQ ID NO：1、SEQ ID NO：5、SEQ ID NO：9、SEQ ID NO：13、SEQ ID NO：17、SEQ ID NO：21、SEQ ID NO：25、SEQ ID NO：29；SEQ ID NO：33；SEQ ID NO：37及SEQ ID NO：41。
在另一態樣中，本發明提供包括「格式3B」對前驅藥蛋白質之組合物，其包括：a)自N端至C端包括以下之第一蛋白質：i)第一sdABD-TTA；ii)第一結構域連接子；iii)第二sdABD-TTA；iv)第二結構域連接子；iii)自N端至C端包括以下之假Fv結構域：1)包括vhCDR1、vhCDR2及vhCDR3之可變重鏈；2)可裂解連接子；及3)包括iVLCDR1、iVLCDR2及iVLCDR3之第一假可變輕結構域；iv)第三結構域連接子；及v) sdABD-HSA；a)自N端至C端包括以下之第一第二蛋白質：i)第三sdABD-TTA；ii)第四結構域連接子；iii)第四sdABD-TTA；iv)第五結構域連接子；iii)自N端至C端包括以下之假Fv結構域：1)包括VLCDR1、VLCDR2及VLCDR3之可變輕鏈；2)可裂解連接子；及3)包括iVHCDR1、iVHCDR2及iVHCDR3之第一假可變重結構域；iv)第六結構域連接子；v) sdABD-HSA；其中所述第一可變重結構域及所述第一可變輕結構域在締合時能夠結合人類CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子間締合以形成非活性Fv；且其中所述第一可變輕結構域與所述第一假可變重結構域進行分子間締合以形成非活性Fv。
在另一態樣中，格式3A及格式3B蛋白質具有有SEQ ID NO：45之sdABD-HSA。
在另一態樣中，格式3A及格式3B蛋白質具有結合至選自EGFR、EpCAM、FOLR1及B7H3之TTA的sdABD-TTA。sdABD-TTA可選自由以下組成之群：SEQ ID NO：1、SEQ ID NO：5、SEQ ID NO：9、SEQ ID NO：13、SEQ ID NO：17、SEQ ID NO：21、SEQ ID NO：25、SEQ ID NO：29；SEQ ID NO：33；SEQ ID NO：37及SEQ ID NO：41。
在另一態樣中，本發明提供包括編碼前驅藥對之第一蛋白質成員的第一核酸及編碼所述對之第二蛋白質成員的第二核酸之核酸組合物以及含有所述核酸之表現載體及宿主細胞。
相關申請的交叉引用
本申請根據35 U.S.C.§119(e)要求2017年9月8日提交之美國臨時專利申請62/555,943、2017年11月15日提交之美國臨時專利申請62/586,627及2017年11月16日提交之美國臨時專利申請62/587,318之優先權，所述申請全部均以全文引用的方式明確地併入本文中。 A.前言
本發明涉及減少結合至諸如CD3及腫瘤抗原之重要的生理學靶標之雙特異性抗體(包含類抗體功能蛋白)之毒性及副作用之方法。諸如抗體之許多抗原結合蛋白可具有顯著的脫靶副作用，且因此僅需要活化疾病組織附近之治療分子之結合能力以避免脫靶相互作用。因此，本發明涉及具有多個功能性蛋白質結構域之多價條件性有效的(「MCE」)蛋白質。一般而言，此等結構域中之一者為將結合靶腫瘤抗原(TTA)之抗原結合結構域(ABD)，且另一者為將在特定條件下結合諸如CD3之T細胞抗原之ABD。另外，MCE蛋白亦包含一或多個蛋白酶裂解位點。亦即治療分子以類「前驅藥」格式製備，其中CD3結合結構域為非活性的直至曝露於腫瘤環境。腫瘤環境含有蛋白酶以使得在曝露於蛋白酶時，前驅藥受到裂解且變得具有活性。
這在本文中通常藉由使用包含「假」可變重結構域及針對諸如CD3之T細胞抗原之「假」可變輕結構域之蛋白質來實現，所述蛋白質將MCE之CD3 Fv抑制成如本文中所論述之非活性格式。由於TTA將MCE靶向腫瘤附近，因此MCE曝露於蛋白酶。在裂解後，活性可變重結構域及活性輕結構域現在能夠配對以形成一或多種針對CD3之活性ABD，因此將T細胞募集至腫瘤，引起治療。
一般而言，CD3結合結構域(「Fv」)呈限制性格式，其中傳統上形成Fv之在活性可變重結構域與活性可變輕結構域之間的連接子太短而不允許兩個活性可變結構域彼此結合；這被稱為「限制性連接子」；此等可受到限制且可裂解(CCL，如格式1中所使用)或受到限制且不可裂解(CNCL，如格式2中所使用)。相反，在前驅藥(例如未裂解)格式中，前驅藥多肽亦包括「假Fv結構域」。假Fv結構域包括具有標準構架區但具有「惰性」或「非活性」CDR之可變重及輕結構域。假Fv結構域亦在非活性可變重結構域與非活性可變輕結構域之間具有限制性連接子。因為Fv結構域及假Fv結構域由於空間限制而不能自行組合，所以存在由於各者之構架區之親和力而使具有iVH之aVL及具有iVL之aVH配對之分子內組合。然而，由於假結構域之「惰性」CDR，所以所得ABD不會結合CD3，因此防止脫靶毒性。然而，在存在腫瘤內或腫瘤附近之蛋白酶之情況下，前驅藥構築體受到裂解以使得假Fv結構域自表面釋放，因此允許「真」可變重結構域及可變輕結構域進行分子間締合(例如兩個裂解構築體聚集在一起)，從而觸發活性CD3結合及所得腫瘤效能。此等構築體在本文中一般稱為條件性雙特異性重導向活化構築體或「COBRAs™」。藉由本文之條件性實驗顯示分子內組合之穩定性，由此在不存在蛋白酶之情況下，未裂解構築體不具有活性(例如未形成活性CD3結合結構域)。
引人注意地為，為了易於描述，雖然此等構築體在本文中均稱為「限制性的」，但額外的工作顯示，即使Fv結構域中之一者不受限制，分子內組合亦為有利的，例如所述結構域中之一者可具有較長的可撓性連接子。亦即如圖36、圖37及圖38中所示，若僅Fv結構域中之一者(具有活性VL及VH之結構域或假Fv結構域)受到限制，則分子內組合仍然進行(例如未裂解構築體在不存在蛋白酶裂解之情況下為非活性的)。然而，在現行系統中，當兩個連接子均受到限制時，蛋白質具有更好的表現。然而，如本領域技術人員所應瞭解，本文之格式1、格式2或格式4構築體中之任何構築體可具有此等具有「非限制性」或「可撓性」連接子之Fv結構域中之一者。為了易於參考，在兩個呈限制性格式之Fv結構域之情況下顯示構築體。
本發明之構築體及格式為WO2017/156178中所描述之發明之變異體，所述案以引用的方式明確地併入此處。如圖20中所示，先前構築體由於存在單多肽中之兩組VH及VL結構域而能夠進行異構化，形成二價scFv及單鏈雙抗體。即使在純化各異型體後，二價構築體仍可達成與雙抗體異型體之平衡。由於單鏈雙抗體在不存在蛋白酶裂解之情況下能夠結合至CD3，所以構築體之利用減少。
為了解決此問題，本發明提供四種獨立類型之構築體來完成此條件性活化。前驅藥活化可以四種一般方式中之一者發生，如圖中一般所示。在圖1中，顯示「格式1」機制。在此實施例中，前驅藥構築體具有兩個裂解位點：一者位於限制性Fv之VH結構域與vl結構域之間，因此釋放兩個可變結構域以進行締合，且第二者位於自前驅藥構築體釋放假Fv結構域之位點，留下兩個由於可變重結構域及可變輕結構域之固有自行組合而締合之分子，各分子亦具有針對腫瘤抗原之抗原結合結構域，因此允許T細胞募集至腫瘤位點。
在替代實施例中，前驅藥構築體示於圖2「格式2」機制中。在此實施例中，活性可變重鏈與活性輕鏈之間之結構域連接子受到限制但不為可裂解連接子(「CNCL」)。在前驅藥格式中，限制性假Fv結構域之非活性VH及VL與限制性Fv結構域之VH及VL締合以使得不存在CD3結合。然而，一旦腫瘤環境中發生裂解，兩種不同的活化蛋白質(每種包括活性可變重結構域及輕結構域)進行締合以形成兩個抗CD3結合結構域。
除了上面所論述之「單鏈蛋白」COBRA格式之外，其中所有組分均含於單胺基酸序列上，亦存在依賴於兩種成對起作用之蛋白質「半COBRA」之構築體，如圖3中所示。在此實施例中，每種蛋白質具有經蛋白酶裂解位點分離之一個活性可變結構域及一個惰性可變結構域。每個分子含有TTA結合結構域以使得當分子結合至TTA且曝露於腫瘤蛋白酶時，惰性結構域發生裂解，且兩個活性可變結構域自行組合以形成抗CD3結合結構域。
此外，本發明亦提供「格式4」構築體，如圖4中所描繪。此等構築體與「格式2」設計類似，不同之處在於使用針對TTA之單ABD以使得在裂解後，兩種前驅藥分子現在形成含有兩個活性抗CD3結構域之四價雙特異性構築體，如下面進一步所描述。
因此，本發明之格式及構築體發現在治療疾病中之用途。 B.定義
為了可更完全地理解應用，下面列出了幾個定義。此等定義意謂涵蓋語法等效物。
本文所使用之「胺基酸」及「胺基酸同一性」意謂20種天然存在之胺基酸中之一種或可存在於特定的規定位置處之任何非天然類似物。在許多實施例中，「胺基酸」意謂20種天然存在之胺基酸中之一種。本文中之「蛋白質」意謂至少兩種包含蛋白質、多肽、寡肽及肽之共價連接之胺基酸。
本文中之「胺基酸修飾」意謂多肽序列中之胺基酸取代、嵌入及/或缺失或化學連接至蛋白質之部分之改變。舉例而言，修飾可為連接至蛋白質之改變的碳水化合物或PEG結構。為清楚起見，除非另有說明，否則胺基酸修飾始終為由DNA編碼之胺基酸，例如具有DNA及RNA中之密碼子之20種胺基酸。本文中之較佳胺基酸修飾為取代。
本文中之「胺基酸取代」或「取代」意謂用不同胺基酸取代在親體多肽序列中之特定位置處之胺基酸。特定言之，在一些實施例中，取代為不在特定位置天然存在之胺基酸，亦即不在有機體內天然存在或不在任何有機體中天然存在之胺基酸。為清楚起見，已經工程化以改變核酸編碼序列但不改變起始胺基酸(例如將CGG(編碼精胺酸)交換為CGA(仍然編碼精胺酸)以提高宿主有機體表現量)之蛋白質不為「胺基酸取代」；亦即，不管生成編碼相同蛋白質之新型基因，但若蛋白質在其起始之特定位置處具有相同的胺基酸，則其不為胺基酸取代。
本文所使用之「胺基酸嵌入」或「嵌入」意謂在親體多肽序列中之特定位置處之胺基酸序列的添加。
本文所使用之「胺基酸缺失」或「缺失」意謂在親體多肽序列中之特定位置處之胺基酸序列的移除。
如本文所概述，本發明之多肽特異性結合至CD3及靶腫瘤抗原(TTA)，諸如靶細胞受體。「特異性結合特定抗原或表位」或「特異性結合至特定抗原或表位」或「對特定抗原或表位具有特異性」意謂與非特異性相互作用可量測地不同的結合。特異性結合可例如藉由確定與對照分子結合相比之分子結合來量測，所述對照分子一般為不具有結合活性之類似結構之分子。舉例而言，特異性結合可藉由與類似於靶標之對照分子競爭來確定。
特定抗原或表位之特異性結合可例如藉由抗原或表位之KD為以下之抗體來展現：至少約10 -4M、至少約10 -5M、至少約10 -6M、至少約10 -7M、至少約10 -8M、至少約10 -9M、可替代地至少約10 -10M、至少約10 -11M、至少約10 -12M或更高，其中KD係指特定抗體-抗原相互作用之解離速率。典型地，特異性結合抗原之抗體之KD將比與抗原或表位相關之對照分子之KD高20倍、50倍、100倍、500倍、1000倍、5,000倍、10,000倍或更多倍。
此外，特定抗原或表位之特異性結合可例如藉由抗原或表位之KA或Ka比與對照物相關之表位之KA或Ka高至少20倍、50倍、100倍、500倍、1000倍、5,000倍、10,000倍或更多倍之抗體來展現，其中KA或Ka係指特定抗體-抗原相互作用之締合速率。一般使用本領域已知之Biacore分析或Octet來量測結合親和力。
本文所使用之「親體多肽」或「前驅體多肽」(包含Fc親體或前驅體)意謂隨後經修飾以產生變異體之多肽。所述親體多肽可為天然存在之多肽或天然存在之多肽之變化或工程化型式。親體多肽可指多肽本身、包括親體多肽之組合物或編碼其之胺基酸序列。因此，本文所使用之「親體Fc多肽」意謂經修飾以產生變異體之未修飾Fc多肽，且本文所使用之「親體抗體」意謂經修飾以產生變異體抗體之未修飾抗體。
本文所使用之「位置」意謂蛋白質之序列中之位置。位置可按順序編號或根據建立之格式編號，例如用於抗體編號之EU索引。
本文所使用之「靶抗原」意謂藉由給定抗體之可變區特異性結合之分子。靶抗原可為蛋白質、碳水化合物、脂質或其他化學化合物。本文描述一系列合適的例示性靶抗原。
本文所使用之「靶細胞」意謂表現靶抗原之細胞。一般而言，出於本發明之目的，靶細胞為表現TTA之腫瘤細胞或表現CD3抗原之T細胞。
本文所使用之「Fv」或「Fv結構域」或「Fv區」意謂包括一般來自抗體之抗原結合結構域之VL及VH結構域之多肽。若Fv結構域含有活性VH及VL結構域，則其通常形成如本文所論述之「抗原結合結構域」或「ABD」(但在一些情況下，使用含有限制性連接子之Fv以使得在裂解之前不形成活性ABD)。如下所述，Fv結構域可在本發明中以多種方式組織成，且可為「活性的」或「非活性的」，諸如呈scFv格式、限制性Fv格式、假Fv格式等。應理解，在本發明中，在一些情況下，Fv結構域由諸如圖1及圖2中所示之單多肽鏈上之VH及VL結構域構成但具有限制性連接子以使得不能形成分子內ABD。在此等實施例中，在裂解後才形成兩個活性ABD。在一些情況下，Fv結構域由VH及VL結構域構成，其中一者為惰性的，從而使得僅在裂解後形成分子間ABD。如下所述，Fv結構域可在本發明中以多種方式組織成，且可為「活性的」或「非活性的」，諸如呈scFv格式、限制性Fv格式、假Fv格式等。另外，如本文所論述，含有VH及VL之Fv結構域可為/形成ABD，且不含有VH及VL結構域之其他ABD可使用sdABD來形成。
本文中之「可變結構域」意謂包括一或多個由分別構成κ、λ及/或重鏈免疫球蛋白遺傳基因座之Vκ、Vλ及/或VH基因實質上編碼之Ig結構域之免疫球蛋白區。在一些情況下，可使用單可變結構域，諸如sdFv(在本文中亦稱為sdABD)。
在利用可變重(VH)結構域及可變輕(VL)結構域之實施例中，各VH及VL由按以下順序自胺基端至羧基端排列之三個高變區(「互補決定區」、「CDR」)及四個「構架區」或「FR」構成：FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4。因此，VH結構域具有結構vhFR1-vhCDR1-vhFR2-vhCDR2-vhFR3-vhCDR3-vhFR4，且VL結構域具有結構vlFR1-vlCDR1-vlFR2-vlCDR2-vlFR3-vlCDR3-vlFR4。如本文所更全面地描述，vhFR區及vlFR區自行組合以形成Fv結構域。一般而言，在本發明之前驅藥格式中，存在「限制性Fv結構域」，其中VH及VL結構域不能自行締合，且存在「假Fv結構域」，因為在自行締合時CDR不形成抗原結合結構域。
高變區賦予抗原結合特異性，且一般涵蓋來自輕鏈可變區中之約胺基酸殘基24-34(LCDR1；「L」表示輕鏈)、50-56(LCDR2)及89-97(LCDR3)之胺基酸殘基及重鏈可變區中之約31-35B(HCDR1；「H」表示重鏈)、50-65(HCDR2)及95-102(HCDR3)周圍之胺基酸殘基；Kabat等人，《免疫學關注的蛋白質序列(SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST)》，第5版。馬利蘭州貝什斯達之國立衛生研究院保健局。(1991)及/或彼等形成高變環之殘基(例如輕鏈可變區中之殘基26-32(LCDR1)、50-52(LCDR2)及91-96(LCDR3)及重鏈可變區中之26-32(HCDR1)、53-55(HCDR2)及96-101(HCDR3))；Chothia及Lesk(1987)《分子生物學期刊(J. Mol. Biol.)》196：901-917。下面描述本發明之特異性CDR。
如本領域技術人員所應瞭解，CDR之確切編號及放置在不同編號系統之間可為不同的。然而，應理解，可變重序列及/或可變輕序列之揭示內容包含相關(固有)CDR之揭示內容。因此，每個可變重區之揭示內容為vhCDR(例如vhCDR1、vhCDR2及vhCDR3)之揭示內容，且每個可變輕結構域之揭示內容為vlCDR(例如vlCDR1、vlCDR2及vlCDR3)之揭示內容。
CDR編號之有用比較如下，參見Lafranc等人，《發育和比較免疫學(Dev. Comp. Immunol.)》27(1)：55-77(2003)。 表1
   Kabat+ Chothia IMGT Kabat AbM Chothia 接觸
vhCDR1 26-35 27-38 31-35 26-35 26-32 30-35
vhCDR2 50-65 56-65 50-65 50-58 52-56 47-58
vhCDR3 95-102 105-117 95-102 95-102 95-102 93-101
vlCDR1 24-34 27-38 24-34 24-34 24-34 30-36
vlCDR2 50-56 56-65 50-56 50-56 50-56 46-55
vlCDR3 89-97 105-117 89-97 89-97 89-97 89-96
在本說明書通篇，當提及可變結構域中之殘基(約輕鏈可變區中之殘基1-107及重鏈可變區中之殘基1-113)及用於Fc區之EU編號系統時，一般使用Kabat編號系統。(例如Kabat等人，同上(1991))。
本發明提供大量不同的CDR組。在此情況下，抗CD3組分之上下文中之「完整CDR組」包括三個可變輕CDR及三個可變重CDR，例如vlCDR1、vlCDR2、vlCDR3、vhCDR1、vhCDR2及vhCDR2。如本領域技術人員所應瞭解，每組CDR(亦即VH及VL CDR)可單獨地及作為一組結合至抗原。舉例而言，在限制性Fv結構域中，vhCDR可結合例如至CD3，且vlCDR可結合至CD3，但在限制性格式中其不能結合至CD3。
在單結構域ABD(「sdABD」)諸如本文通常用於結合至靶腫瘤抗原(TTA)之單結構域ABD之上下文中，CDR組僅為三個CDR；此等結構域有時在本領域中亦稱為「VHH」結構域。
此等CDR可分別為較大的可變輕結構域或可變重結構域之一部分。另外，如本文所更全面地概述，在scFv序列之情況下，視本文中之部分的格式及組態而定，可變重結構域及可變輕結構域可在單獨多肽鏈上或在單多肽鏈上。
CDR有助於形成抗原結合，或更特定地，形成表位結合位點。「表位」係指與稱為互補位之可變區中之特定抗原結合位點相互作用之決定因子。表位為諸如胺基酸或糖側鏈之分子之群，且通常具有特異性結構特徵以及特異性電荷特徵。單抗原可具有超過一個表位。
表位可包括直接參與結合之胺基酸殘基(亦稱為表位之免疫顯性組分)及其他不直接參與結合之胺基酸殘基，諸如經特異性抗原結合肽有效阻斷之胺基酸殘基；換言之，胺基酸殘基在特異性抗原結合肽之覆蓋區內。
表位可為構形的或線性的。構形表位係藉由來自線性多肽鏈之不同區段之空間上斜接的胺基酸產生的。線性表位為由多肽鏈中之相鄰胺基酸殘基產生之表位。構形及非構形表位之區別可能在於，在變性溶劑存在之情況下，與前者而非後者之結合消失。
表位典型地包含獨特空間構形中之至少3個且更通常至少5或8-10個胺基酸。識別相同表位之抗體可在簡單的免疫分析中驗證，其顯示一種抗體阻斷另一種抗體與靶抗原之結合的能力，例如「合併」。如下所概述，本發明不僅包含本文所列舉之抗原結合結構域及抗體，亦包含競爭與由所列舉之抗原結合結構域結合之表位結合的抗原結合結構域及抗體。
本發明之可變重結構域及可變輕結構域可為「活性的」或「非活性的」。
如本文所使用之「非活性VH」(「iVH」)及「非活性VL」(「iVL」)係指假Fv結構域之組分，其在分別與其同源VL或VH配偶體配對時形成所得VH/VL對，若所述VH/VL對結合至不為「非活性的」類似VL或VH，則其不特異性結合至將與「活性」VH或「活性」VL結合之抗原。例示性「非活性VH」及「非活性VL」結構域係藉由如下面更全面概述之野生型VH或VL序列之突變來形成的。例示性突變在VH或VL之CDR1、CDR2或CDR3內。例示性突變包含將結構域連接子置於CDR2內，由此形成「非活性VH」或「非活性VL」結構域。相反，「活性VH」或「活性VL」在分別與其「活性」同源配偶體(亦即VL或VH)配對後能夠特異性結合至其靶抗原。因此，應理解，假Fv可為VH/iVL對、iVH/VL對或iVH/iVL對。
相反，如本文所使用，術語「活性」係指能夠特異性結合至CD-3之CD-3結合結構域。此術語在兩種情況下使用：(a)當提及Fv結合對之單成員(亦即VH或VL)時，所述對具有能夠與其同源配偶體配對且特異性結合至CD-3之序列；(b)具有能夠特異性結合至CD-3之序列之同源物對(亦即VH及VL)。例示性「活性」VH、VL或VH/VL對為野生型或親體序列。
「CD-x」係指分化簇(CD)蛋白質(a cluster of differentiation(CD) protein)。在例示性實施例中，CD-x選自彼等在投予本發明之多肽構築體之個體中之T細胞募集或活化中具有重要作用之CD蛋白。在一例示性實施例中，CD-x為CD3，其序列顯示於圖5。
結合本發明，術語「結合結構域」表徵與例如EGFR及CD-3之靶分子(抗原)上之給定靶表位或給定靶位點分別進行(特異性)結合/相互作用/分別識別例如EGFR及CD-3之靶分子(抗原)上之給定靶表位或給定靶位點。靶抗原結合結構域(識別EGFR)之結構及功能且較佳附加地CD-3結合結構域(識別CD3)之結構及/或功能基於例如包含sdABD之全長或完整免疫球蛋白分子之抗體的結構及/或功能。根據本發明，靶抗原結合結構域之特徵一般在於存在結合至靶腫瘤抗原之三個CDR(本領域中一般稱為可變重結構域，但不存在對應的輕鏈CDR)。可替代地，針對TTA之ABD可包含三個輕鏈CDR(亦即VL區之CDR1、CDR2及CDR3)及/或三個重鏈CDR(亦即VH區之CDR1、CDR2及CDR3)。CD-3結合結構域較佳亦至少包括允許靶結合之最低結構性要求之抗體。更佳地，CD-3結合結構域包括至少三個輕鏈CDR(亦即VL區之CDR1、CDR2及CDR3)及/或三個重鏈CDR(亦即VH區之CDR1、CDR2及CDR3)。設想在例示性實施例中，靶抗原及/或CD-3結合結構域由噬菌體呈現或文庫篩選方法產生或獲得。
本文所使用之「結構域」意謂具有如本文所概述之功能之蛋白質序列。本發明之結構域包含腫瘤靶抗原結合結構域(TTA結構域)、可變重結構域、可變輕結構域、連接子結構域及半衰期延長結構域。
本文中之「結構域連接子」意謂連接本文所概述之兩個結構域之胺基酸序列。結構域連接子可為可裂解連接子、限制性可裂解連接子、不可裂解連接子、限制性不可裂解連接子、scFv連接子等。
本文中之「可裂解連接子」(「CL」)意謂可經蛋白酶、較佳如本文所概述之疾病組織中之人類蛋白酶裂解之胺基酸序列。可裂解連接子之長度一般為至少3個胺基酸且視所要求之可撓性而定具有4、5、6、7、8、9、10、11、12、13、14、15或更多個發現用於本發明之胺基酸。多種可裂解連接子序列在圖6及圖5中發現。
本文中之「不可裂解連接子」(「NCL」)意謂在正常生理條件下不能經人類蛋白酶裂解之胺基酸序列。
本文中之「限制性可裂解連接子」(「CCL」)意謂含有蛋白酶裂解位點(如本文所定義)之短多肽，所述蛋白酶裂解位點以使得兩個結構域在其滯留於不同多肽鏈上之前(例如在裂解之前)不能彼此顯著地相互作用之方式來連接如本文所概述之兩個結構域當CCL連接如本文所定義之VH及VL結構域時，由於以分子內方式進行空間限制，所以VH及VL不能在裂解之前自行組合以形成功能性Fv(但其可以分子間方式組合成假Fv結構域)。在經相關蛋白酶裂解後，VH及VL可以分子間方式組合以形成活性抗原結合結構域。一般而言，CCL之長度小於10個胺基酸且具有9、8、7、6、5及4個發現用於本發明之胺基酸。一般而言，蛋白酶裂解位點之長度一般為至少4+個胺基酸以賦予足夠的特異性，如在圖6中所示。
本文中之「限制性不可裂解連接子」(「CNCL」)意謂以使得兩個結構域不能彼此顯著地相互作用且使得其在生理條件下不會經人類蛋白酶顯著地裂解之方式來連接如本文所概述之兩個結構域的短多肽。
本文中之「限制性Fv結構域」意謂包括活性可變重結構域及活性可變輕結構域之Fv結構域，其以使得活性重可變結構域及輕可變結構域不能進行分子內相互作用以形成將結合諸如CD3之抗原之活性Fv的方式與本文所概述之限制性連接子共價連接。因此，限制性Fv結構域為類似於scFv但由於存在限制性連接子而不能結合抗原之結構域(但其可與惰性可變結構域進行分子間組合以形成假Fv結構域)。
本文中之「假Fv結構域」意謂包括使用結構域連接子(其可為可裂解、限制性、不可裂解、非限制性的等)連接之假或非活性可變重結構域或假或非活性可變輕結構域或兩者之結構域。假Fv結構域之iVH及iVL結構域在彼此締合時(iVH/iVL)或在與活性VH或VL締合時不與人類抗原結合；因此，iVH/iVL、iVH/VL及iVL/VH Fv結構域不明顯地與人類蛋白質結合，從而使得此等結構域在人體中為惰性的。
本文中之「單鏈Fv」或「scFv」意謂一般使用如本文所論述之結構域連接子共價連接至可變輕(VL)結構域以形成scFv或scFv結構域之可變重(VH)結構域。scFv結構域可處於自N端至C端之任一方位(VH-連接子-VL或VL-連接子-VH)。
本文中之「單結構域Fv」、「sdFv」或「sdABD」意謂一般基於camelid抗體技術僅具有三個CDR之抗原結合結構域。參見：《蛋白質工程(Protein Engineering)》9(7)：1129-35(1994)；《分子生物技術評論(Rev Mol Biotech)》74：277-302(2001)；《生物化學年評(Ann Rev Biochem)》82：775-97(2013)。如本文所概述，存在本文所使用之兩種一般類型之sdABD：結合至TTA且如此註釋(對於通用術語為sdABD-TTA，或對於結合至EGFR之sdABD為sdABD-EGFR，對於結合至FOLR1之sdABD為sdABD-FOLR1等)之sdABD及結合至HSA之sdABD(「sdABD-HSA」或「sdABD(½)」)。
「蛋白酶裂解位點」係指經識別且經蛋白酶裂解之胺基酸序列。合適的蛋白酶裂解位點在下面概述且顯示於圖5及圖6。
如本文所使用之「蛋白酶裂解結構域」係指合併「蛋白酶裂解位點」及個別蛋白酶裂解位點之間的任何連接子以及一或多個蛋白酶裂解位點與本發明構築體之其他功能組分之間的任何連接子之肽序列(例如V H、V L、iVH、iVL、一或多個靶抗原結合結構域、半衰期延長結構域等)。如本文所概述，若需要，則蛋白酶裂解結構域亦可包含額外的胺基酸例如以賦予可撓性。
術語「COBRA™」及「條件性雙特異性重導向活化」係指具有多個功能性蛋白質結構域之雙特異性條件性有效的蛋白質。在一些實施例中，功能性結構域中之一者為結合靶腫瘤抗原(TTA)之抗原結合結構域(ABD)。在某些實施例中，另一結構域為在特定條件下結合至T細胞抗原之ABD。T細胞抗原包含但不限於CD3。術語「半COBRA™」係指當由於當在靶表現細胞之表面上濃縮時先天性自行組合，半COBRA之可變重鏈可締合至另一半COBRA™(互補性半COBRA™)之可變輕鏈時可結合T細胞抗原之條件性有效的蛋白質。 II.本發明之融合蛋白
本發明之融合蛋白具有以多種方式連接在一起之多種不同組分，在本文中一般稱為結構域。一些結構域為各自結合至靶抗原(例如TTA或CD3)之結合結構域。當其結合至超過一種抗原時，其在本文中稱為「多特異性的」；舉例而言，本發明之前驅藥構築體可結合至TTA及CD3，且因此為「雙特異性的」。蛋白質亦可具有更高的特異性；舉例而言，若第一αTTA與EGFR結合，第二αTTA與EpCAM結合且存在抗CD3結合結構域，則此將為「三特異性」分子。類似地，向此構築體中添加抗HSA結合結構域將為「四特異性的」，如圖3B中所示。
如本領域技術人員所應瞭解，本發明之蛋白質可具有不同的價態且為多特異性的。亦即，本發明之蛋白質可結合具有超過一個結合位點之靶標；舉例而言，Pro140對於EGFR為二價的。
本發明之蛋白質可包含以如本文所概述之多種方式排列之CD3抗原結合結構域、腫瘤靶抗原結合結構域、半衰期延長結構域、連接子等。 A. CD3抗原結合結構域
T細胞之反應之特異性係由藉由T細胞受體複合物識別抗原(呈現於主要組織相容性複合物MHC之上下文中)來介導。作為T細胞受體複合物之一部分，CD3為蛋白質複合物，其包含存在於細胞表面處之CD3γ(γ)鏈、CD3δ(δ)鏈、兩個CD3e(ε)鏈及兩個CD3ζ(ζ)鏈。CD3分子與T細胞受體(TCR)之α(α)鏈及β(β)鏈締合以構成TCR複合物。諸如藉由結合至CD3之Fv結構域進行之T細胞上之CD3叢集引起類似於T細胞受體之接合但不依賴於其純系-典型的特異性之T細胞活化。
然而，如本領域中已知，CD3活化可導致多種毒副作用，且因此本發明涉及僅在腫瘤細胞存在之情況下提供本發明之多肽之活性CD3結合，其中發現特異性蛋白酶，隨後裂解本發明之前驅藥多肽以提供活性CD3結合結構域。因此，在本發明中，抗CD-3 Fv結構域與CD-3之結合係經蛋白酶裂解結構域調節，所述蛋白酶裂解結構域僅在具有高量蛋白酶之病變細胞或組織之微環境中，例如在本文所描述之腫瘤微環境中限制CD-3 Fv結構域與CD-3之結合。
因此，本發明提供兩組VH及VL結構域、一活性組(VH及VL)及一非活性組(iVH及iVL)，其中四組全部均存在於前驅藥構築體中。對構築體進行格式化以使得VH及VL組不能自行締合，而與例如如本文所示之iVH及VL以及iVL及VH之非活性配偶體締合。 1.活性抗CD3可變重結構域及可變輕結構域
存在許多本領域已知且發現用於本發明之合適的活性CDR組及/或VH及VL結構域。舉例而言，CDR及/或VH及VL結構域係衍生自已知的抗CD-3抗體，例如莫羅莫那-CD-3(muromonab-CD-3)(OKT3)、奧昔珠單抗(otelixizumab)(TRX4)、替利珠單抗(teplizumab)(MGA031)、維西珠單抗(visilizumab)(Nuvion)、SP34或I2C、TR-66或X35-3、VIT3、BMA030(BW264/56)、CLB-T3/3、CRIS7、YTH12.5、F111-409、CLB-T3.4.2、TR-66、WT32、SPv-T3b、11D8、XIII-141、XIII-46、XIII-87、12F6、T3/RW2-8C8、T3/RW2-4B6、OKT3D、M-T301、SMC2、F101.01、UCHT-1及WT-31。
在一個實施例中，形成結合至人類CD3之活性Fv結構域之VH及VL序列分別顯示於圖5中。如本文所示，此等活性VH(「aVH」)及活性VL(「aVL」)結構域可以不同組態及格式1、2、3及4來使用。 2.非活性抗CD3可變重結構域及可變輕結構域
非活性iVH及iVL結構域含有允許締合之「有規則的」構架區(FR)以使得非活性可變結構域將與活性可變結構域締合，使對變為非活性的，例如不能結合CD3。
如本領域技術人員所應瞭解，存在許多發現用於本發明之「非活性」可變結構域。基本上，無論可變區中之CDR位置中之胺基酸為何種胺基酸，可使用具有允許與另一可變結構域自行組合之人類構架區之任何可變結構域。為清楚起見，據稱非活性結構域包含CDR，但自技術上而言，非活性可變結構域不賦予結合能力。
如本領域所瞭解，一般直接產生非活性VH或VL結構域且可以多種方式進行。在一些實施例中，非活性可變結構域之產生通常藉由改變活性Fv之一或多個CDR來進行，其包含改變活性可變結構域之三個CDR中之一或多者。這可藉由在一或多個CDR中之功能上重要的殘基處進行一或多個胺基酸取代，用無規序列替換一些或所有CDR殘基，用標記或標示序列替換一或多個CDR，且/或將CDR及/或可變區與來自無關抗體之CDR及/或可變區(例如一個針對不同有機體之蛋白質之CDR及/或可變區)交換來完成。
在一些情況下，可僅改變可變區中之多個CDR中之一者以使其變為非活性的，但其他實施例包含改變一個、兩個、三個、四個、五個或六個CDR。
在一些情況下，可工程化非活性結構域以促進前驅藥格式中之選擇性結合以促進在裂解之前形成分子內iVH-VL及VH-iVL結構域(例如經由分子間對形成)。參見例如Igawa等人，《蛋白質工程化設計及選擇(Protein Eng. Des. Selection)》23(8)：667-677(2010)，其以全文引用的方式明確地併入此處，且特別地用於界面殘基胺基酸取代。
在某些實施例中，本文所描述之多肽構築體之CD-3結合結構域不僅展現出與人類CD-3之強CD-3結合親和力，而且亦展現與相應的食蟹猴CD-3蛋白之優異的交叉反應性。在一些情況下，多肽構築體之CD-3結合結構域可與來自食蟹猴之CD-3交叉反應。在某些情況下，關於CD-3之人類：食蟹猴KD比率在5與0.2之間。
在一些實施例中，抗原結合蛋白之CD-3結合結構域可為結合至CD-3之任何結構域，其包含但不限於來自單株抗體、多株抗體、重組抗體、人類抗體、人類化抗體之結構域。在一些情況下，CD-3結合結構域衍生自最終將使用抗原結合蛋白之相同物種為有益的。舉例而言，對於人類使用，抗原結合蛋白之CD-3結合結構域包括來自抗體或抗體片段之抗原結合結構域之人類或人類化殘基可能為有益的。
因此，在一個態樣中，抗原結合結構域包括人類化或人類結合結構域。在一個實施例中，人類化或人類抗CD-3結合結構域包括一或多個(例如所有三個)輕鏈互補決定區1(LC CDR1)、輕鏈互補決定區2(LC CDR2)及本文所描述之人類化或人類抗CD-3結合結構域之輕鏈互補決定區3(LC CDR3)，及/或一或多個(例如所有三個)重鏈互補決定區1(HC CDR1)、重鏈互補決定區域2(HC CDR2)及本文所描述之人類化或人類抗CD-3結合結構域(例如包括一或多個(例如所有三個)LC CDR及一或多個(例如所有三個)HC CDR之人類化或人類抗CD-3結合結構域)之重鏈互補決定區3(HC CDR3)。
在一些實施例中，人類化或人類抗CD-3結合結構域包括對CD-3具有特異性之人類化或人類輕鏈可變區，其中對CD-3具有特異性之輕鏈可變區包括人類輕鏈構架區中之人類或非人類輕鏈CDR。在某些情況下，輕鏈構架區為λ(λ)輕鏈構架。在其他情況下，輕鏈構架區為κ(κ)輕鏈構架。
在一些實施例中，一或多個CD-3結合結構域為人類化的或全長人類的。在一些實施例中，一或多個活化CD-3結合結構域針對CD-3表現細胞上之CD-3之KD結合為1000 nM或更低。在一些實施例中，一或多個活化CD-3結合結構域針對CD-3表現細胞上之CD-3之KD結合為100 nM或更低。在一些實施例中，一或多個活化CD-3結合結構域針對CD-3表現細胞上之CD-3之KD結合為10 nM或更低。在一些實施例中，一或多個CD-3結合結構域與食蟹猴CD-3存在交叉反應性。在一些實施例中，一或多個CD-3結合結構域包括本文所提供之胺基酸序列。
在一些實施例中，人類化或人類抗CD-3結合結構域包括對CD-3具有特異性之人類化或人類重鏈可變區，其中對CD-3具有特異性之重鏈可變區包括人類重鏈構架區中之人類或非人類重鏈CDR。
在一個實施例中，抗CD-3結合結構域為包括具有本文所提供之胺基酸序列之輕鏈及重鏈之Fv。在一實施例中，抗CD-3結合結構域包括：輕鏈可變區，其包括具有本文所提供之輕鏈可變區之胺基酸序列之至少一種、兩種或三種修飾(例如取代)但不超過30、20或10種修飾(例如取代)之胺基酸序列，或具有與本文所提供之胺基酸序列之95-99%同一性之序列；及/或重鏈可變區，其包括具有本文所提供之重鏈可變區之胺基酸序列之至少一種、兩種或三種修飾(例如取代)但不超過30、20或10種修飾(例如取代)之胺基酸序列，或具有與本文所提供之胺基酸序列之95-99%同一性之序列。在一個實施例中，人類化或人類抗CD-3結合結構域為scFv，且包括本文所描述之胺基酸序列之輕鏈可變區經由scFv連接子與包括本文所描述之胺基酸序列之重鏈可變區連接。具有scFv之輕鏈可變區及重鏈可變區可在例如任何以下方位中：輕鏈可變區-scFv連接子-重鏈可變區或重鏈可變區-scFv連接子-輕鏈可變區。
在一些實施例中，抗原結合蛋白之CD-3結合結構域對CD-3表現細胞上之CD-3具有親和力，且KD為1000 nM或更低、100 nM或更低、50 nM或更低、20 nM或更低、10 nM或更低、5 nM或更低、1 nM或更低或0.5 nM或更低。在一些實施例中，抗原結合蛋白之CD-3結合結構域對CD-3ε具有親和力，且KD為1000 nM或更低、100 nM或更低、50 nM或更低、20 nM或更低、10 nM或更低、5 nM或更低、1 nM或更低或0.5 nM或更低。在另外的實施例中，抗原結合蛋白之CD-3結合結構域對CD-3具有低親和力，亦即約100 nM或更高。
結合中CD-3之親和力可如本領域所知一般使用Biacore或Octet分析例如藉由抗原結合蛋白本身或其CD-3結合結構域結合至之CD-3之能力來確定，所述CD-3包被在分析板上；呈現在微生物細胞表面上；處於溶液中；等。可藉由將配位體(例如CD-3)或抗原結合蛋白本身或其CD-3結合結構域固化至珠粒、基質、細胞等來分析本發明之抗原結合蛋白本身或其CD-3結合結構域與CD-3之結合活性。可在合適的緩衝液中添加試劑，且在給定溫度下將結合配偶體保溫一段時間。在經洗滌以移除未結合物質後，可用例如SDS、具有高pH之緩衝液及其類似物來釋放結合蛋白質，且例如藉由表面電漿子共振(SPR)來進行分析。
在許多實施例中，較佳活性及惰性結合結構域為彼等顯示於圖5中之結構域。 B.針對腫瘤靶抗原之抗原結合結構域
除了所描述之CD3及半衰期延長結構域之外，本文所描述之多肽構築體亦包括結合至一或多種靶抗原或單靶抗原上之一或多個區域之靶結構域。本文預期，本發明之多肽構築體例如在疾病特異性微環境中或在蛋白酶裂解結構域處之個體之血液中進行裂解，且預期每個靶抗原結合結構域將與靶細胞上之靶抗原結合，因此活化CD3結合結構域以結合T細胞。一般而言，TTA結合結構域可在蛋白酶裂解之前與其靶標結合，因此其可在待活化為T細胞接合子之靶細胞上「等待」。至少一種靶抗原參與疾病、病症或病況及/或與疾病、病症或病況相關。例示性靶抗原包含彼等與增生性疾病、腫瘤性疾病、發炎性疾病、免疫性病症、自身免疫疾病、傳染性疾病、病毒性疾病、過敏反應、寄生反應、移植物抗宿主疾病或宿主抗移植物疾病相關之抗原。在一些實施例中，靶抗原為表現於腫瘤細胞上之腫瘤抗原。可替代地，在一些實施例中，靶抗原與諸如病毒或細菌之病原體相關。至少一種靶抗原亦可對抗健康組織。
在一些實施例中，靶抗原為細胞表面分子，諸如蛋白質、脂質或多醣。在一些實施例中，靶抗原為腫瘤細胞、病毒感染之細胞、細菌感染之細胞、受損紅細胞、動脈斑塊細胞或纖維化組織細胞。
本發明之較佳實施例利用sdABD作為靶向結構域。此等結構域優於scFv ABD，因為將其他VH及VL結構域添加至本發明之構築體中可能使假Fv結構域之形成複雜化。
在一些實施例中，本發明之前驅藥構築體利用單TTA結合結構域諸如一般描繪於圖3A中之單TTA結合結構域作為sdABD-TTA對，及一般描繪於圖4中之單TTA結合結構域作為「格式4」組態。圖4顯示使用單抗EGFR ABD，但可使用其他TTA結合結構域。
在一些實施例中，特別地在格式1及格式2構築體中，本發明之前驅藥構築體利用再次較佳地呈sdABD-TTA格式之兩種TTA ABD。當使用雙重靶向結構域時，其可結合至相同的TTA之相同表位。舉例而言，如本文所論述，本文中之多種構築體利用兩個相同的靶向結構域。在一些實施例中，可使用結合至相同的TTA之不同表位的兩個靶向結構域，舉例而言，如圖5中所示，結合至人類EGFR之不同表位的兩個EGFR sdABD。在一些實施例中，兩個靶向結構域結合至不同的TTA，參見例如圖54。
本文所預期之多肽構築體包含至少一個抗原結合結構域，其中抗原結合結構域結合至至少一種靶抗原。在一些實施例中，靶抗原結合結構域特異性結合至細胞表面分子。在一些實施例中，靶抗原結合結構域特異性結合至腫瘤抗原。在一些實施例中，靶抗原結合結構域特異性地且獨立地結合至選自以下中至少一者之腫瘤靶抗原(「TTA」)：EpCAM、EGFR、HER-2、HER-3、cMet、LyPD3、B7H3、CEA及FOLR1。
本發明特別使用如圖5中所示之針對人類EGFR之sdABD。
本發明中使用之另外實施例為如圖5中所示之針對人類FOLR1之sdABD。
本發明中使用之另外實施例為如圖5中所示之針對人類B7H3之sdABD。
本發明中使用之另外實施例為如圖5中所示之針對人類EpCAM之sdABD。
在一些實施例中，蛋白酶裂解結構域裂解之前之蛋白質小於約100 kDa。在一些實施例中，蛋白酶裂解結構域裂解之後之蛋白質為約25至約75 kDa。在一些實施例中，蛋白酶裂解之前之蛋白質之尺寸大於第一次通過之清除之腎閾(renal threshold)。在一些實施例中，蛋白酶裂解之前之蛋白質之消除半衰期為至少約50小時。在一些實施例中，蛋白酶裂解之前之蛋白質之消除半衰期為至少約100小時。在一些實施例中，與針對相同靶抗原之IgG相比，蛋白質具有增加的組織滲透。在一些實施例中，與針對相同靶抗原之IgG相比，蛋白質具有增加的組織分佈。 C.半衰期延長結構域
本發明之MCE蛋白質(另外在本文中亦稱為「COBRA™」蛋白質或構築體)視情況包含半衰期延長結構域。預期所述結構域包含但不限於HSA結合結構域、Fc結構域、小分子及本領域已知之其他半衰期延長結構域。
人類血清白蛋白(HSA)(分子質量~67 kDa)為以約50 mg/ml(600 uM)存在之血漿中之最豐富的蛋白質，且在人類中之半衰期為約20天。HSA用於維持血漿pH，有助於膠體血壓，充當許多代謝物及脂肪酸之載體，且用作血漿中之主要藥物傳輸蛋白。
與白蛋白之非共價締合延長了短壽命蛋白質之消除半衰期。舉例而言，與單獨投予Fab片段相比，當分別靜脈內投予至小鼠及兔子時，白蛋白結合結構域與Fab片段之重組融合分別導致活體內清除率降低25倍及58倍且半衰期延長26倍及37倍。在另一實例中，當用脂肪酸醯化胰島素以促進與白蛋白之締合時，在兔或豬中皮下注射時觀察到延長效應。同時此等研究證實了白蛋白結合與延長作用之間的聯繫。
在一個態樣中，本文所描述之抗原結合蛋白包括半衰期延長結構域，例如特異性結合至HSA之結構域。在其他實施例中，HSA結合結構域為肽。在另外的實施例中，HSA結合結構域為小分子。在一些實施例中，預期抗原結合蛋白之HSA結合結構域相當小且不超過25 kD、不超過20 kD、不超過15 kD或不超過10 kD。在某些情況下，若HSA結合結構域為肽或小分子，則其為5 kD或更小。
在許多實施例中，半衰期延長結構域為來自結合至HSA之單結構域抗體之單結構域抗原結合結構域。此結構域在本文中一般稱為針對人類HSA之「sdABD」(sdABD-HSA)或可替代地「sdABD(½)」以將此等結合結構域與針對TTA之sdABD區分開。一種特別有用之sdABD(½)示於圖5中。
抗原結合蛋白之半衰期延長結構域提供抗原結合蛋白本身之改變的藥效學及藥物動力學。如上所述，半衰期延長結構域延長消除半衰期。半衰期延長結構域亦改變藥效學特性，其包含改變組織分佈、滲透及抗原結合蛋白之擴散。在一些實施例中，與不存在半衰期延長結合結構域之蛋白質相比，半衰期延長結構域提供改進的組織(包含腫瘤)靶向、組織滲透、組織分佈、組織內擴散及增強的效能。在一個實施例中，治療方法有效且有效率地利用減少量之抗原結合蛋白，引起副作用降低，諸如降低之非腫瘤細胞細胞毒性。
此外，例如HSA結合結構域之半衰期延長結構域之特徵包含HSA結合結構域對HSA之結合親和力。可選擇所述HSA結合結構域之親和力以便在特定多肽構築體中靶向特定的消除半衰期。因此，在一些實施例中，HSA結合結構域具有高結合親和力。在其他實施例中，HSA結合結構域具有中等結合親和力。在其他實施例中，HSA結合結構域具有低或邊緣結合親和力。例示性結合親和力包含在10 nM或更低(高)、在10 nM與100  nM(中等)及高於100 nM(低)之間下之KD濃度。如上所述，藉由諸如表面電漿子共振(SPR)之已知方法來確定對HSA之結合親和力。 D.蛋白酶裂解位點
本發明之蛋白質組合物且特別地前驅藥構築體包含一或多個蛋白酶裂解位點，通常位於如本文所概述之可裂解連接子中。
如本文所描述，本發明之前驅藥構築體包含至少一個蛋白酶裂解位點，其包括經至少一種蛋白酶裂解之胺基酸序列。在一些情況下，本文所描述之MCE蛋白包括1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20或更多個之經至少一種蛋白酶裂解之蛋白酶裂解位點。如本文所更全面地論述，當在前驅藥構建中使用超過一個蛋白酶裂解位點時，其可為相同的(例如經單蛋白酶裂解之多個位點)或不同的(經至少兩種不同的蛋白酶裂解之兩個或更多個裂解位點)。如本領域技術人員所應瞭解，含有三個或更多個蛋白酶裂解位點之構築體可利用一個、兩個、三個位點等；舉例而言，一些構築體可利用三個位點以用於兩種不同的蛋白酶等。
蛋白酶裂解位點之胺基酸序列將視所靶向的蛋白酶而定。如本領域已知，存在多種在體內發現且可能與疾病狀態相關之人類蛋白酶。
已知蛋白酶由一些病變細胞及組織例如腫瘤或癌細胞分泌，產生富含蛋白酶之微環境或蛋白酶富含的微環境。在一些情況下，個體之血液富含蛋白酶。在一些情況下，腫瘤周圍之細胞將蛋白酶分泌至腫瘤微環境中。腫瘤分泌蛋白酶周圍之細胞包含但不限於腫瘤基質細胞、肌纖維母細胞、血細胞、肥大細胞、B細胞、NK細胞、調節性T細胞、巨噬細胞、細胞毒性T淋巴細胞、樹突細胞、間葉系幹細胞、多形核細胞及其他細胞。在一些情況下，蛋白酶存在於個體之血液中，例如靶向微生物肽中發現之胺基酸序列之蛋白酶。此特性允許靶向治療劑諸如抗原結合蛋白具有額外的特異性，因為除了在靶向蛋白或組織之蛋白酶富含之微環境中外，T細胞不會由抗原結合蛋白結合。
蛋白酶為在一些情況下以序列特異性方式裂解蛋白質之蛋白質。蛋白酶包含但不限於絲胺酸蛋白酶、半胱胺酸蛋白酶、天冬胺酸蛋白酶、蘇胺酸蛋白酶、麩胺酸蛋白酶、金屬蛋白酶、天冬醯胺肽裂解酶、血清蛋白酶、組織蛋白酶(例如組織蛋白酶B、組織蛋白酶C、組織蛋白酶D、組織蛋白酶E、組織蛋白酶K、組織蛋白酶L、組織蛋白酶S)、激肽釋放酶、hK1、hK10、hK15、KLK7、粒酶B、纖維蛋白溶酶、膠原酶、IV型膠原酶、基質溶素、因子XA、類胰凝乳蛋白酶蛋白酶、類胰蛋白酶蛋白酶、類彈性蛋白酶蛋白酶、類枯草桿菌蛋白酶蛋白酶、奇異果蛋白酶(actinidain)、鳳梨酵素、鈣蛋白酶、凋亡蛋白酶(例如凋亡蛋白酶-3)、Mir1-CP、木瓜酶、HIV-1蛋白酶、HSV蛋白酶、CMV蛋白酶、凝乳酶、腎素、胃蛋白酶、間質蛋白酶、豆莢蛋白、半胱胺酸蛋白酶、豬籠草蛋白酶、金屬外肽酶、金屬內肽酶、基質金屬蛋白酶(MMP)、MMP1、MMP2、MMP3、MMP8、MMP9、MMP13、MMP11、MMP14、穿膜肽酶、尿激酶纖維蛋白溶酶原活化物(uPA)、腸激酶、前列腺特異性抗原(PSA，hK3)、介白素-1β轉化酶、凝血酶、FAP(FAP-α)、二肽基肽酶及二肽基肽酶IV(DPPIV/CD26)。
一些合適的蛋白酶及蛋白酶裂解序列示於圖5及圖6中。 E.連接子
如本文所論述，本發明之不同結構域一般使用胺基酸連接子連接在一起，所述胺基酸連接子亦可賦予功能性，其包含可撓性或不可撓性(例如空間限制)以及使用原位蛋白酶裂解之能力。此等連接子可以多種方式分類。
本發明提供「結構域連接子」，其用於連接兩個或更多個結構域(例如VH及VL，針對VH或VL之靶腫瘤抗原結合結構域(TTABD，有時在本文中亦稱為「αTTA」)(用於「抗TTA」))、針對另一組分之半衰期延長結構域等)。舉例而言，結構域連接子可為不可裂解的(NCL)、可裂解的(「CL」)、限制性且可裂解氟(CCL)以及限制性且不可裂解的(CNCL)。 1.不可裂解連接子
在一些實施例中，結構域連接子為不可裂解的。一般而言，此等結構域連接子可為兩種類型中之一種：不可裂解且可撓性，其允許構築體中之連接子之「上游」及「下游」組分以特定方式進行分子內自行組合；或不可裂解且限制性，其中經連接子分離之兩個組分不能進行分子內自行組合。然而，應注意，在後一種情況下，雖然經不可裂解限制性連接子分離之兩個組分結構域不進行分子內自行組合，但其他分子內組分將自行組合以形成假Fv結構域。 (i)不可裂解但可撓性連接子
在此實施例中，連接子用於一般經由不經患者中之原位蛋白酶裂解之較長的可撓性結構域連接結構域以保留結構域之功能。適於連接本發明多肽中之結構域之內部不可裂解連接子之實例包含但不限於(GS)n、(GGS)n、(GGGS)n、(GGSG)n、(GGSGG)n或(GGGGS)n，其中n為1、2、3、4、5、6、7、8、9或10。在一些實施例中，連接子之長度可為約15個胺基酸。 (ii)不可裂解且限制性連接子
在一些情況下，連接子不含有裂解位點且亦太短而不允許經連接子分離之蛋白質結構域進行分子內自行組合，且為「限制性不可裂解連接子」或「CNCL」。舉例而言，在Pro186中，活性VH及活性VL經不允許VH及VL自行組合成活性抗原結合結構域之8個胺基酸(「8聚體」)分離。在一些實施例中，連接子仍為可撓性的；例如(GGGS)n，其中n=2。在其他實施例中，儘管一般不太較佳，但可使用更剛性的連接子，諸如包含脯氨酸或大體積胺基酸之連接子。 2.可裂解連接子
本文中之所有前驅藥構築體包含至少一個可裂解連接子。因此，在一個實施例中，結構域連接子為可裂解的(CL)，在本文中有時稱為「蛋白酶裂解結構域」(「PCD」)。在此實施例中，CL含有蛋白酶裂解位點，如本文中所概述及如圖5及圖6中所描繪。在一些情況下，CL僅含有蛋白酶裂解位點。視情況，視裂解識別位點之長度而定，在CL之N端或C端末端中之任一個或兩個處可存在額外的少量連接胺基酸；舉例而言，在裂解位點之N端及C端中之任一個或兩個上可存在1、2、3、4或5個胺基酸。因此，可裂解連接子亦可為限制性(例如8聚體)或可撓性的。
在本發明中受到特別關注的為MMP9可裂解連接子及穿膜肽酶可裂解連接子，特別地MMP9限制性可裂解連接子及穿膜肽酶限制性可裂解連接子。 III.本發明之結構域
本發明為本發明之前驅藥多肽提供了多種不同的格式。本發明提供限制性Fv結構域及限制性假Fv結構域。另外，本發明提供多價條件性有效的(「MCE」)蛋白質，其含有兩個Fv結構域但為非異構化構築體。如本文所概述，此等結構域可為非異構化可裂解格式或非異構化不可裂解格式，但每個構築體含有至少一個蛋白酶裂解結構域。
重要地，儘管這兩個結構域(Fv結構域及假Fv結構域)在本文中稱為「限制性」，這意謂如上面所論述及圖36圖37及圖38中所示，但僅此等結構域中之一者需要受到限制，儘管一般而言，當兩個連接子受到限制時，蛋白質具有更好的表現。
本領域技術人員應瞭解，對於格式1、2及4，本發明之限制性且假Fv結構域之N端至C端順序存在四種可能性(未顯示連接子)：aVH-aVL及iVL-iVH、aVH-aVL及iVH-iVL、aVL-aVH及iVL-iVH、aVL-aVH及iVH-iVL。四種可能性全部已經過測試且四種可能性全部均有活性，但第一順序aVH-aVL及iVL-iVH顯示比其他三個更好的表現。因此，雖然本文中之描述一般以此aVH-aVL及iVL-iVH格式示出，但本文之所有揭示內容亦包含用於此等結構域之其他順序。
注意，一般而言，本發明之全長構築體之N端至C端順序基於aVH-aVL及iVL-iVH方位。
另外，本領域已知，在人類中可能存在源自特定ABD之C端序列之免疫原性。因此，一般而言，特別地當構築體之C端終止於sdABD時(舉例而言，許多構築體之sdABD-HSA結構域)，可使用組胺酸標記物(His6或His10)。出於純化原因，本文中之許多或大多數序列係使用His6 C端標記物產生，但此等序列亦可用於降低人類中之免疫原性，如由Holland等人的DOI 10.1007/s10875-013-9915-0及WO2013/024059所示。 A.限制性Fv結構域
本發明提供包括使用限制性連接子(如本文所概述，其可為可裂解的(格式1及3)或不可裂解的(格式2及4))共價連接之活性VH及活性VL結構域之限制性Fv結構域。限制性連接子在不存在裂解之情況下防止aVH與aVL之間之分子內締合。因此，限制性Fv結構域一般包括可變結構域內含有的一組六個CDR，其中VH之vhCDR1、vhCDR2及vhCDR3結合人類CD-3且VL之vlCDR1、vCDR2及vlCDR3結合人類CD-3，但在前驅藥格式(例如未裂解)中，VH及VL不能進行空間地締合以形成活性結合結構域，較佳代替在假Fv情況下進行分子內配對。
限制性Fv結構域可包括如本文所描述之活性VH及活性VL(aVH及aVL)或非活性VH及VL(iVH及iVL，在此情況下其為限制性假Fv結構域)或其組合。
如本領域技術人員所應瞭解，限制性Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
如本文所概述，在諸如彼等示於圖5及圖6中之連接子之情況下，對於格式1構築體，限制性Fv結構域可包括使用可裂解連接子連接之VH及VL。在此實施例中，限制性Fv結構域具有結構(N端至C端)vhFR1-vhCDR1-vhFR2-vhCDR2-vhFR3-vhCDR3-vhFR4-CCL-vlFR1-vlCDR1-vlFR2-vlCDR2-vlFR3-vlCDR3-vlFR4。一般而言，限制性Fv結構域含有活性VH及VL結構域(例如當締合時能夠結合CD3)，且因此具有結構(N端至C端)vhFR1-avhCDR1-vhFR2-avhCDR2-vhFR3-avhCDR3-vhFR4-CCL-vlFR1-avlCDR1-vlFR2-avlCDR2-vlFR3-avlCDR3-vlFR4。
如本文所概述，對於格式2構築體，限制性Fv結構域可包括使用不可裂解連接子連接之VH及VL。在此實施例中，限制性Fv結構域具有結構(N端至C端)vhFR1-vhCDR1-vhFR2-vhCDR2-vhFR3-vhCDR3-vhFR4-CNCL-vlFR1-vlCDR1-vlFR2-vlCDR2-vlFR3-vlCDR3-vlFR4。一般而言，限制性Fv結構域含有活性VH及VL結構域(例如當締合時能夠結合CD3)，且因此具有結構(N端至C端)vhFR1-avhCDR1-vhFR2-avhCDR2-vhFR3-avhCDR3-vhFR4-CNCL-vlFR1-avlCDR1-vlFR2-avlCDR2-vlFR3-avlCDR3-vlFR4。
本發明特別使用有具有SEQ ID NO：61之aVH、具有SEQ ID NO：49之aVL及具有SEQ ID NO：74之結構域連接子之限制性不可裂解Fv結構域。 B.限制性假Fv結構域
本發明提供限制性假Fv結構域，其包括使用限制性連接子(如本文所概述，其可為可裂解或不可裂解的)共價連接之非活性或假iVH及iVL結構域。限制性連接子在不存在裂解之情況下防止iVH與iVL之間之分子內締合。因此，限制性假Fv結構域一般包括具有構架區之iVH及iVL，所述構架區允許iVH及iVL之締合(當呈非限制性格式時)，但所得假Fv結構域不結合至人類蛋白。iVH結構域可與aVL結構域組合，且iVL結構域可與aVH結構域組合，但所得結構不與CD3結合。
限制性假Fv結構域包括非活性VH及VL(iVH及iVL)。
如本領域技術人員所應瞭解，限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
如本文所概述，限制性假Fv結構域可包括使用如格式1、2及4中所示之不可裂解連接子或用如格式3所示之可裂解連接子連接之iVH及iVL。
一般而言，限制性Fv結構域含有惰性VH及VL結構域(例如當締合時能夠結合CD3)，且因此具有結構(N端至C端)vhFR1-ivlCDR1-vhFR2-ivlCDR2-vhFR3-ivlCDR3-vhFR4-CNCL-vlFR1-ivhCDR1-vlFR2-ivhCDR2-vlFR3-ivhCDR3-vlFR4。
本發明特別使用有具有SEQ ID NO：65或SEQ ID NO：69之iVH、具有SEQ ID NO：53或SEQ ID NO：57之iVL之限制性不可裂解假Fv結構域及具有SEQ ID NO：74之結構域連接子。 IV.本發明之格式 如本文所論述，本發明之前驅藥構築體可採用多種不同之格式，其包含具有雙TTA結合結構域之可裂解格式、具有雙TTA結合結構域之不可裂解格式(其中任一種可具有相同的TTA結合結構域或不同的結合結構域)及具有單靶向結構域之不可裂解格式。 A.具有雙重靶向之可裂解格式
本發明提供圖1中之「格式1」類型之非異構化可裂解格式。在此實施例中，限制性Fv結構域包括使用限制性可裂解連接子連接之VH及VL結構域及限制性假Fv結構域使用限制性不可裂解連接子。為了易於論述，這兩種格式在本文中稱為「限制性」，但如上面所論述及在圖36圖37及圖38中，僅此等格式中之一種需要受到限制，但一般而言，當兩個連接子均受到限制時，蛋白質具有更好的表現。
格式1(以及其他格式)中之所有構築體亦具有經人類腫瘤蛋白酶裂解之可裂解連接子(CL)。
本發明提供前驅藥蛋白質，其自N端至C端包括(sdABD-TTA1)-結構域連接子限制之Fv結構域-結構域連接子-(sdABD-TTA2)-CL-限制性假Fv結構域-結構域連接子-sdABD-HSA。
如本領域技術人員所應瞭解，限制性Fv結構域或限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVH-CCL-iVL-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVL-CCL-aVH-結構域連接子-(sdABD-TTA2)-CL-iVL-CCL-iVH-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVL-CCL-aVH-結構域連接子-(sdABD-TTA2)-CL-iVH-CCL-iVL-結構域連接子-sdABD-HSA。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-NCL-sdABD(½)。在此實施例中，aVH、aVL、iVH及iVL具有顯示於圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至相同的TTA，所述TTA可為EGFR、EpCAM、FOLR1或B7H3，其序列描繪於圖5中。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至不同的TTA。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及EpCAM結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及FOLR1結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及B7H3結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EpCAM及FOLR1結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EpCAM及B7H3結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與B7H3及FOLR1結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥構築體包括sdABD(TTA1)-結構域連接子-aVH-CCL-aVL-結構域連接子-sdABD(TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD (½)。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至相同的TTA，所述TTA可為EGFR、FOLR1、B7H3或EpCAM，其序列描繪於圖5中，且CCL及CL選自經MMP9或穿膜肽酶裂解之連接子，且sdABD(½)具有SEQ ID NO：45。
在格式1中，較佳的結構域連接子為SEQ ID NO：74(其亦用作較佳的限制性不可裂解連接子)。
在格式1中，較佳構築體為Pro140及 Pro140b。 B.不可裂解格式
如圖2中所示，本發明提供非異構化不可裂解格式。在此實施例中，應理解，「不可裂解的」僅應用於限制性Fv結構域之連接，因為在前驅藥構築體中存在活化裂解位點。在此實施例中，限制性Fv結構域包括使用限制性不可裂解連接子連接之VH及VL結構域，且限制性假Fv結構域使用限制性不可裂解連接子。
如本領域技術人員所應瞭解，限制性Fv結構域或限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
本發明提供前驅藥蛋白質，其自N端至C端包括sdABD(TTA1)-結構域連接子-限制性Fv結構域-結構域連接子-sdABD(TTA2)-可裂解連接子-限制性假Fv結構域-結構域連接子-sdABD-HSA。
如本領域技術人員所應瞭解，限制性Fv結構域或限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVH-CNCL-iVL-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVL-CNCL-aVH-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVL-CNCL-aVH-結構域連接子-(sdABD-TTA2)-CL-iVH-CNCL-iVL-結構域連接子-sdABD-HSA。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至相同的TTA，所述TTA可為EGFR、EpCAM、FOLR1或B7H3，其序列描繪於圖5中。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至不同的TTA。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及EpCAM結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及FOLR1結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EGFR及B7H3結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EpCAM及FOLR1結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與EpCAM及B7H3結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域與FOLR1及B7H3結合，且sdABD-TTA具有圖5中之序列。
在一些實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA1)-結構域連接子-aVH-CNCL-aVL-結構域連接子-(sdABD-TTA2)-CL-iVL-CNCL-iVH-結構域連接子-sdABD-HSA。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，兩個靶向結構域結合至相同的TTA，所述TTA可為EGFR、FOLR1、B7H3或EpCAM，其序列描繪於圖5中，且CCL及CL選自經MMP9或穿膜肽酶裂解之連接子，且sdABD(½)具有SEQ ID NO：45。
在格式2中，較佳的結構域連接子為SEQ ID NO：74(其亦用作較佳的限制性不可裂解連接子)。
在格式2中，具有特定用途之實施例包含但不限於Pro186、Pro225、Pro226、Pro233、Pro311、Pro312、Pro313、Pro495、Pro246、Pro254、Pro255、Pro256、Pro420、Pro421、Pro432、Pro479、Pro480、Pro187、Pro221、Pro222、Pro223、Pro224、Pro393、Pro394、Pro395、Pro396、Pro429、Pro430及Pro431。 C.單TTA構築體
如圖4中所示，本發明之組合物亦包含類似於格式2構築體但無第二TTA ABD之「格式4」構築體。在此實施例中，應理解，「不可裂解的」僅應用於限制性Fv結構域之連接，因為在前驅藥構築體中存在活化裂解位點。在此實施例中，限制性Fv結構域包括使用限制性不可裂解連接子連接之VH及VL結構域，且限制性假Fv結構域使用限制性不可裂解連接子。
如本領域技術人員所應瞭解，限制性Fv結構域或限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
本發明提供前驅藥蛋白質，其自N端至C端包括sdABD(TTA)-結構域連接子-限制性Fv結構域-可裂解連接子-sdABD-HSA-限制性假Fv結構域。(注意，對於用於此格式之所有構築體，sdABD-HSA一般不具有His6標記物，但其可包含在內)。
如本領域技術人員所應瞭解，限制性Fv結構域或限制性假Fv結構域中之VH及VL之順序可為(N端至C端)VH-連接子-VL或VL-連接子-VH。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA)-結構域連接子-aVH-CNCL-aVL-CL-(sdABD-HSA)-結構域連接子-iVL-CNCL-iVH。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA)-結構域連接子-aVH-CNCL-aVL-CL-(sdABD-HSA)-結構域連接子-iVH-CNCL-iVL。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA)-結構域連接子-aVL-CNCL-aVH-CL-(sdABD-HSA)-結構域連接子-iVH-CNCL-iVL。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA)-結構域連接子-aVL-CNCL-aVH-CL-(sdABD-HSA)-結構域連接子-iVL-CNCL-iVH。
因此，在一個實施例中，前驅藥蛋白質自N端至C端包括：(sdABD-TTA)-結構域連接子-aVH-CNCL-aVL-CL-(sdABD-HSA)-結構域連接子-iVL-CNCL-iVH。在此實施例中，aVH、aVL、iVH、iVL具有顯示於圖5中之序列。在此實施例中，靶向結構域結合至TTA，所述TTA可為EGFR、EpCAM、FOLR1或B7H3，其序列描繪於圖5中。
在格式4中，較佳的結構域連接子為SEQ ID NO：74(其亦用作較佳的限制性不可裂解連接子)。
在格式4中，較佳sdABD-HSA為具有SEQ ID NO：45之sdABD-HSA。 D.兩種蛋白質組合物
在一些實施例中，本發明之組合物包括在不存在裂解之情況下進行分子內締合以形成假Fv之兩種不同之分子，有時稱為「半COBRA™」或「半構築體」。在蛋白酶存在之情況下，裂解位點受到裂解，釋放出惰性可變結構域，且蛋白質對隨後形成針對CD3之活性抗原結合結構域，如在圖3大體所描繪。
在半構築體之設計中重要的為，活性可變結構域及sdABD-TTA在裂解後保持在一起，從而使得兩個裂解部分藉由腫瘤表面上之腫瘤抗原受體保持在一起，且隨後可形成活性抗CD3結合結構域。
有兩種不同的通用格式3構築體，其中所述對之每個成員具有單sdABD-TTA(圖3A)之彼等構築體，及具有兩種不同的sdABD-TTA且每一個針對不同的TTA(圖3B)之彼等構築體。 1.半COBRA™構築體具有單TTA結合結構域(格式3A)
在一些實施例中，第一半COBRA™自N端至C端具有sdABD(TTA1)-結構域連接子-aVH-CL-iVL-結構域連接子-sdABD(½)，且第二半COBRA™具有sdABD(½)-結構域連接子-iVH-CL-aVL-結構域連接子-sdABD(TTA2)。在此實施例中，aVH、aVL、iVH、iVL及sdABD(½)已具有顯示於圖5中之序列且sdABD-TTAA結合至人類EGFR、EpCAM、FOLR1及/或B7H3且具有描繪於圖5中之序列。 2.具有雙TTA ABD之半COBRA™構築體
在一些實施例中，成對前驅藥構築體可具有兩個sdABD-TTA結合結構域/構築體，如在圖3B中所示在此實施例中，所述對之第一成員自N端至C端包括sdABD-TTA1-結構域連接子-sdABD-TTA2-結構域連接子-aVH-CL-iVL-結構域連接子-sdABD(HAS)，且第二成員自N端至C端包括sdABD-TTA1-結構域連接子-sdABD-TTA2-aVL-CL-iVH-結構域連接子-sdABD-HSA。
所述對中之每個成員上之兩個sdABD-TTA為不同的，但一般而言，兩個成員(半COBRA™)均具有相同的兩個sdABD-TTA，例如兩者均具有EGFR及FOLR1或EGFR及B7H3等。
兩個sdABD-TTA均在選自顯示於圖5中之實施例之一些實施例中。 V.製備本發明之組合物之方法
本發明之前驅藥組合物係如本領域技術人員一般所瞭解且如下面所概述來製備。
本發明提供編碼本發明之前驅藥組合物之核酸組合物。如本領域技術人員所應瞭解，核酸組合物將視一或多種前驅藥多肽之格式而定。因此，舉例而言，當所述格式需要兩種胺基酸序列時，諸如「格式3」構築體，可將兩個核酸序列併入一或多個表現載體中以用於表現。類似地，作為單多肽(格式1、2及4)之前驅藥構築體在單表現載體中需要單核酸以用於生產。
如本領域所知，編碼本發明之組分之核酸可如本領域已知且視用於產生本發明之前驅藥組合物之宿主細胞而定來併入表現載體中。一般而言，核酸可與任何數量之調節性元素(啟動子、複製起源、可選擇標記、核醣體結合位點、誘導物等)操作性連接。表現載體可為染色體外載體或整合載體。
隨後將本發明之核酸及/或表現載體轉化成本領域眾所周知之任何數量之不同類型的宿主細胞，其包含哺乳動物、細菌、酵母、昆蟲及/或真菌細胞，且發現哺乳動物細胞(例如CHO細胞、293細胞)用於許多實施例中。
如本領域所眾所周知，藉由培養包括一或多種表現載體之宿主細胞來製備本發明之前驅藥組合物。一旦產生，則進行傳統的抗體純化步驟，其包含蛋白質A親和力層析步驟及/或離子交換層析步驟。 VI.本發明之前驅藥組合物之調配及投予
製備根據本發明使用之前驅藥組合物之調配物以用於儲存，這係藉由呈凍乾調配物或水溶液形式之混合具有所需純度之視情況選用之醫藥學上可接受之載劑、賦形劑或穩定劑(如Remington之《藥物科學(Pharmaceutical Sciences)》第16版，Osol, A.編[1980]中大體所概述)之前驅藥(在格式1、2及4之情況下單蛋白質，且在格式3之情況下兩種蛋白質)來進行的。
根據已知方法在一段時間內將本發明之前驅藥組合物投予至個體，諸如以推注形式之靜脈內投予或藉由連續輸注。
本發明之前驅藥組合物可用於治療癌症。 VII.實例 A.實例1：Pro構築體構築及純化
轉染
由單獨之表現載體(pcdna3.4衍生物)表現每種蛋白質(例如用於格式1、2及4之單蛋白質)或構築體對(格式3)。將編碼一對半cobra或單鏈構築體之等量質體DNA混合且遵循製造商之轉染協定轉染成Expi293細胞。轉染後5天內藉由離心(6000 rpm×25')及過濾(0.2 uM過濾器)收穫條件培養基。藉由SDS-PAGE確認蛋白質表現。純化構築體，且最終緩衝液組合物為：25 mM檸檬酸鹽、75 mM精胺酸、75 mM NaCl、4%蔗糖，pH 7將最終製備物儲存在-80℃下。
MMP9之活化
根據以下協定活化重組人類(rh)MMP9。重組人類MMP-9(R&D # 911-MP-010)為0.44 mg/ml(4.7 uM)。在DMSO中之100 mM儲備濃度下製備對乙酸胺基苯基汞(APMA)(西格瑪(Sigma))。分析緩衝液為50 mM Tris pH  7.5、10 mM CaCl2、150 mM NaCl、0.05% Brij-35。
-用分析緩衝液將rhMMP9稀釋至~100 ug/ml(25 ul hMMP9+75 uL分析緩衝液)
-添加來自DMSO中之100 mM原液中之對乙酸胺基苯基汞(APMA)至最終濃度為1 mM(1 uL至100 uL)
-在37℃下保溫24小時
-將MMP9稀釋至10 ng/ul(向100 ul活化溶液中添加900 ul分析緩衝液)
活化rhMMP9之濃度為~100 nM。
用於TDCC分析之構築體之裂解
為了裂解構築體，向調配物緩衝液(25 mM檸檬酸、75 mM L-精胺酸、75 mM NaCl、4%蔗糖)中之在1 mg/ml濃度(10.5 uM)下之100 ul蛋白質樣品中供應高達10 mM之CaCl 2。添加活化rhMMP9至濃度為20-35 nM。將樣品在室溫下保溫過夜(16-20小時)。使用SDS PAGE(10-20%TG，TG運行緩衝液，200v，1小時)驗證裂解之完成度。樣品典型地進行98%裂解。 B.實例2：T細胞依賴性細胞毒性(TDCC)分析
將螢火蟲螢光素酶轉導之HT-29細胞生長至約80%匯合性且用維耳新(Versene)(PBS-Ca-Mg中之0.48 mM EDTA)分離。將細胞離心且重懸浮於TDCC培養基(具有HEPES、GlutaMax、丙酮酸鈉、非必需胺基酸及β-巰基乙醇之RPMI 1640中之5%熱非活化FBS)中。將純化之人類Pan-T細胞解凍、離心且重懸浮於TDCC培養基中。
將HT-29_Luc細胞及T細胞之共培養物添加至384孔細胞培養板中。隨後連續地將稀釋COBRA添加至共培養物中且在37℃下保溫48小時。最後，將相等體積之SteadyGlo螢光素酶分析試劑添加至所述板中且保溫分鐘。在Perkin Elmer Envision上讀取所述板且曝露時間為0.1秒孔。記錄總發光度且在GraphPad Prism 7上分析資料。 C.實例3：活體內接受性T細胞轉移效能模型之通用協定設計設計
此等協定用於許多具有圖示之實驗中。在NSG(NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)小鼠之右腹脅皮下植入(SC)腫瘤細胞( 傑克遜實驗室 (The Jackson Laboratory)，商品目錄號005557)且允許其生長直至達至平均體積為約200 mm 3之已建立腫瘤。平行地，在具有來自T細胞活化/膨脹試劑盒( 美天旎 (Miltenyi )商品目錄號130-091-441)之MACSi珠粒之G-Rex100M透氣燒瓶( Wilson Wolf商品目錄號81100S)中在T細胞培養基(X-VIVO 15[ 龍沙 (Lonza) ，商品目錄號04-418Q]、5%人類血清、1%青黴素/鏈黴素、0.01 mM 2-巰基乙醇)中培養人類T細胞約10天，且補充有重組人類IL-2蛋白。協調小鼠中之腫瘤生長及人類T細胞活化/膨脹以使得在研究之第0天，基於腫瘤尺寸將小鼠隨機分組(N=6)；隨後向各組靜脈注射(IV) 2.5×10 6個所培養之人類T細胞且投予第一劑COBRA或對照分子。小鼠每3天給藥一次至7劑量(第0、3、6、9、12、15及18天)，接著再持續2-3週直至腫瘤體積達至＞2000 mm 3或研究終止。每3天量測一次腫瘤體積。 D.實例4：在EGFR/MMP9半COBRA對Pro77及Pro53情況下之活體內活性
將5×10 6個LoVo細胞或5×10 6個HT29細胞皮下植入至NSG(NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)小鼠( 傑克遜實驗室，商品目錄號005557)之右腹脅中且允許生長直至腫瘤建立。平行地，在具有來自T細胞活化/膨脹試劑盒( 美天旎商品目錄號130-091-441)之MACSi珠粒之G-Rex100M透氣燒瓶( Wilson Wolf商品目錄號81100S)中在T細胞培養基(X-VIVO 15[ 龍沙，商品目錄號04-418Q]、5%人類血清、1%青黴素/鏈黴素、0.01 mM 2-巰基乙醇)中培養人類T細胞10天，且補充有重組人類IL-2蛋白。協調小鼠中之腫瘤生長及人類T細胞活化/膨脹以使得在研究之第0天，基於腫瘤尺寸將小鼠隨機分組(N=6)；隨後向各組靜脈注射(IV)2.5×10 6個所培養之人類T細胞且投予第一劑COBRA或對照分子。小鼠每3天給藥一次至7劑量(第0、3、6、9、12、15及18天)，隨後持續直至腫瘤體積達至＞2000 mm 3或研究終止。各組接受0.2 mg/kg(mpk)抗EGFR×CD3陽性對照物Pro51雙特異性抗體(bsAb)、0.5 mpk陰性對照物抗雞蛋溶菌酶(HEL)×CD3 bsAb Pro98、各0.5 mpk之含有抗EGFR半COBRA對Pro77及Pro53之MMP9可裂解連接子或各0.5 mpk之含有抗EGFR半COBRA對Pro74及Pro72之不可裂解(NCL)連接子。每3天量測一次腫瘤體積。 E.實例5：在EGFR/MMP9 COBRA Pro140情況下之活體內活性
將5×10 6個LoVo細胞或5×10 6個HT29細胞皮下植入至NSG(NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)小鼠( 傑克遜實驗室，商品目錄號005557)之右腹脅中且允許生長直至腫瘤建立。平行地，在具有來自T細胞活化/膨脹試劑盒( 美天旎商品目錄號130-091-441)之MACSi珠粒之G-Rex100M透氣燒瓶( Wilson Wolf商品目錄號81100S)中在T細胞培養基(X-VIVO 15[ 龍沙，商品目錄號04-418Q]、5%人類血清、1%青黴素/鏈黴素、0.01 mM 2-巰基乙醇)中培養人類T細胞10天，且補充有重組人類IL-2蛋白。協調小鼠中之腫瘤生長及人類T細胞活化/膨脹以使得在研究之第0天，基於腫瘤尺寸將小鼠隨機分組(N=6)；隨後向各組靜脈注射(IV)2.5×10 6個所培養之人類T細胞且投予第一劑COBRA或對照分子。小鼠每3天給藥一次至7劑量(第0、3、6、9、12、15及18天)，隨後持續直至腫瘤體積達至＞2000 mm 3或研究終止。各組接受0.2 mpk抗EGFR×CD3陽性對照物Pro51雙特異性抗體(bsAb)、0.5 mpk陰性對照物抗雞蛋溶菌酶(HEL)×CD3 bsAb Pro98或0.5 mpk含有抗EGFR COBRA Pro140之MMP9可裂解連接子。每3天量測一次腫瘤體積。 F.實例6：在EGFR/MMP9 COBRA Pro186情況下之活體內活性
將5×10 6個HT29細胞皮下植入至NSG(NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ)小鼠( 傑克遜實驗室，商品目錄號005557)之右腹脅中且允許生長直至腫瘤建立。平行地，在具有來自T細胞活化/膨脹試劑盒( 美天旎商品目錄號130-091-441)之MACSi珠粒之G-Rex100M透氣燒瓶( Wilson Wolf商品目錄號81100S)中在T細胞培養基(X-VIVO 15 [ 龍沙，商品目錄號04-418Q]、5%人類血清、1%青黴素/鏈黴素、0.01 mM 2-巰基乙醇)中培養人類T細胞10天，且補充有重組人類IL-2蛋白。協調小鼠中之腫瘤生長及人類T細胞活化/膨脹以使得在研究之第0天，基於腫瘤尺寸將小鼠隨機分組(N=6)；隨後向各組靜脈注射(IV)2.5×10 6個所培養之人類T細胞且投予第一劑COBRA或對照分子。小鼠每3天給藥一次至7劑量(第0、3、6、9、12、15及18天)，隨後持續直至腫瘤體積達至＞2000 mm 3或研究終止。各組接受0.1 mg/kg(mpk)抗EGFR×CD3陽性對照物Pro51雙特異性抗體(bsAb)、0.3 mpk之之含有抗EGFR COBRA  Pro214之不可裂解(NCL)對照連接子、0.1或0.3 mpk含有抗EGFR COBRA Pro140之MMP9可裂解連接子或0.1或0.3 mpk含有抗EGFR COBRA Pro186之MMP9可裂解連接子。每3天量測一次腫瘤體積。 G.實例：抗EGFR序列之成功的人類化
結果示於下文。
分子 KD (M) Kon (1/Ms) Kdis(1/s)
Pro22 (親代EGFR) 2.58E-09M/2.6 nM 2.05E+05 5.27E-04
Pro90 (hEGFR1) 2.00E-09M/2.0 nM 2.21E+05 4.40E-04
Pro48 (EGFR2) 2.89E-09M/2.9 nM 6.09E+05 1.76E-03
Pro137 (hEGFR2) 4.36E-09M/4.4. nM 5.85E+05 2.55E-03
Pro51 (hEGFR2) 3.27E-09M/3.2 nM 6.45E+05 2.11E-03
Pro201 (具有2個結合位點之hEGFR2) 2.25E-12M/2.3 pM 1.55E+06 3.48E-06
此等結果表明EGFR結合結構域之人類化為成功的，且當兩個結合位點處於分子上時存在針對靶EGFR之強結合性。
實例：EpCAM sdABD之成功的人類化
結果示於下文。
選殖株 人類結合親和力(nM) 食蟹猴結合親和力(nM) 食蟹猴/人類交叉反應性
VIB-13 2.3 11.6 5
hVIB-13 2.8 12.7 4.5
VIB-23 4.2 46.7 11.1
hVIB-23 4.1 58.8 12.6
此等結果表明EpCAM結合結構域之人類化為成功的。
圖1描繪本發明之「格式1」類型的蛋白酶活化，在本文中稱為「限制性可裂解構築體」或「cc構築體」。在此實施例中，代表性構築體為Pro140：存在用於兩個TTA之ABD(如在圖1中所描繪此等TTA均為相同的，但如本文所描述其可為不同的)。裂解後，前驅藥構築體分裂成三種組分，一種含有經由結構域連接子連接至具有αCD3之活性VH的α-TTA結構域，第二種含有經由結構域連接子連接至具有αCD3之活性VL的α-TTA結構域，且「剩餘」片段包括連接至非活性VH及VL之半衰期延長結構域。隨後，兩個活性可變結構域可自由締合以形成功能性抗CD3結合結構域。應注意，在「格式1」實施例中，所得活性組分為三價的：存在針對CD3之單價結合及針對TTA之二價結合，產生雙特異性結合蛋白，但在一些情況下此三價物可為具有針對CD3之單價結合、針對第一TTA之單價結合及針對第二TTA之單價結合的三特異性物。圖1亦顯示作為半衰期延長結構域之抗人類血清白蛋白(HSA)結構域，在許多實施例中sdABD如本文所定義但如本文所論述，此為視情況選用的且/或可為其他半衰期延長結構域取代；另外，半衰期延長結構域亦可為構築體之N端或附加地內部。圖1亦具有呈特定順序例如自N端至C端之具有Fv之VH及VL以及具有假Fv之iVH及iVL，VH-連接子-VL(及iVL-連接子-iVH)，但如本領域的技術人員所應瞭解，此等順序可進行逆轉(VL-連接子-VH及iVH-連接子-iVL)。可替代地，此等Fv中之一者可在一個方位上而另一者在另一方位上，但此處所示之方位上之蛋白質的表現意外地高於其他方位。 圖2描繪本發明之「格式2」類型的蛋白酶活化，在本文中稱為「限制性不可裂解構築體」或「CNCL構築體」，有時在本文中亦稱為如本文所論述之「二聚化構築體」。此等構築體不會如本文所論述那樣異構化。在裂解後，兩種前驅藥構築體分裂成四種組分，兩種半衰期延長結構域(在此情況下針對HSA之sdABD)連接至兩個假結構域(視連接子之長度及失活突變而定，其可能或可能不能自我締合)，且兩種活性部分自行組合成含有四個抗TTA結構域(可全部相同或兩個為相同的，且另外兩個為不同的)之二聚體活性部分。應注意，在「格式2」實施例中，所得活性組分為六價的：存在針對CD3之二價結合及針對TTA之四價結合，產生雙特異性結合蛋白，但在一些情況下此六價物可為具有針對CD3之二價結合、針對第一TTA之二價結合及針對第二TTA之二價結合的三特異性物。圖2亦顯示作為半衰期延長結構域之抗人類血清白蛋白(HSA)結構域，在許多實施例中sdABD如本文所定義但如本文所論述，此為視情況選用的及/或可為其他半衰期延長結構域取代；另外，半衰期延長結構域亦可為構築體之N端或附加地內部。圖2亦具有呈特定順序例如N端至C端之具有Fv之VH及VL以及具有假Fv之iVH及iVL，VH-連接子-VL(及iVL-連接子-iVH)，但如本領域技術人員所應瞭解，此等順序可進行逆轉(VL-連接子-VH及iVH-連接子-iVL)。可替代地，此等Fv中之一者可在一個方位上而另一者在另一方位上，但此處所示之方位上之蛋白質的表現意外地高於其他方位。 圖3A-圖3B描繪「格式3」類型的構築體，有時亦稱為如本文所概述之「半構築體」或「半COBRA™」，因為此等物為一起構成如本文進一步所進一步論述之MCE治療劑之兩種不同的多肽鏈。在此實施例中，構築體成對遞送且進行預裂解分子內自行組合，產生非活性抗CD3 Fv結構域。在裂解後，釋放惰性可變結構域，隨後兩個活性可變結構域進行分子間組合以形成活性抗CD3結合結構域。兩個sdABD-TTA與腫瘤細胞表面上之相應受體結合，且藉由蛋白酶來進行裂解。這允許分子間組合，因為分子以物理方式保持在適當位置，有利於活性抗CD3結構域之組合。在此實施例中，如上面對於格式1及2，可變結構域之N端至C端順序可進行逆轉或附加地混合。此外，sdABD(HSA)可位於每個半構築體之N端或C端處。Pro16具有C端處之sdABD(HSA)，且Pro17具有N端處之sdABD(HSA)(參見Pro19，SEQ ID NO：XX，具有C端處之sdABD(HSA))。圖3A顯示具有每半構築體存在單sdABD-TTA結構域之格式3構築體，且圖3B顯示具有每半構築體存在兩個sdABD-TTA之格式3構築體，其呈「雙重靶向」或「異源靶向」格式。注意，圖3B使用FOLR1及EGFR作為兩種TTA，但亦可使用本文所概述之其他組合。 圖4描繪類似於「格式2」構築體但僅具有單sdABD-TTA之「格式4」類型的構築體。所述圖顯示針對EGFR之sdABD-TTA，但如本領域技術人員所應瞭解，亦可使用其他TTA。裂解後，前驅藥構築體分裂成兩種組分，一種半衰期延長結構域(在此情況下針對HSA之sdABD)連接至假Fv，且一種活性部分在存在來自不同的裂解分子之第二活性部分之情況下自行組合成含有兩個抗TTA結構域之二聚體活性部分。應注意，在「格式4」實施例中，所得活性組分為四價的：存在針對CD3之二價結合及針對TTA之二價結合，產生雙特異性結合蛋白。圖4亦顯示作為半衰期延長結構域之抗人類血清白蛋白(HSA)結構域，在許多實施例中sdABD(½)如本文所定義但如本文所論述，此為視情況選用的及/或者可為其他半衰期延長結構域取代；另外，半衰期延長結構域亦可為構築體之N端或附加地內部。圖4亦具有呈特定順序例如自N端至C端之具有Fv之VH及VL以及具有假Fv之iVH及iVL，VH-連接子-VL(及iVL-連接子-iVH)，但如本領域技術人員所應瞭解，此等順序可進行逆轉(VL-連接子-VH及iVH-連接子-iVL)。可替代地，此等Fv中之一者可在一個方位上而另一者在另一方位上，但此處所示之方位上之蛋白質的表現意外地高於其他方位。 圖5A-圖5G描繪本發明之多個序列。對於抗原結合結構域，CDR加有底線。如本文中所更全面地概述，此等結構域可在本發明中以廣泛多種的組態組合，包含「格式1」、「格式2」、「格式3」及「格式4」定向。值得注意地，SEQ ID NO：90經MMP9裂解且略快於SEQ ID NO：75及76，且SEQ ID NO：91之裂解慢於SEQ ID NO：75及76之裂解。 圖6A-圖6B描繪多個合適的蛋白酶裂解位點。如本領域技術人員所應瞭解，此等裂解位點可用作可裂解連接子。在一些實施例中，例如當需要更加可撓性可裂解連接子時，可存在另外的胺基酸(通常為甘胺酸及絲胺酸)，其位於此等裂解位點之N端及C端中之一者或兩者處。 圖7A-圖7D描繪與「格式3」或「半COBRA™」結構相關聯之一些資料。這表明，格式3構築體經蛋白酶(在此情況下EK蛋白酶，但可使用本文中所概述且在圖5及圖6中所描繪之任何蛋白酶裂解位點)裂解後可共操作地結合至CD3，且如藉由夾心FACS分析所示創建CD3結合位點。 圖8A-圖8D顯示蛋白酶裂解可與輔助半COBRA™對共操作地活化EGFR+靶細胞之T細胞殺傷。圖8A及圖8B顯示隔離但經不同濃度的蛋白酶裂解之構築體不影響靶細胞生存力。然而，圖8C顯示在蛋白酶存在之情況下組合靶細胞生存力顯著地降低。圖8D顯示通用機制。 圖9顯示在測試格式1構築體之效能之分析中使用的一些非靶對照物。 圖10A-圖10F顯示活性CD3結合結構域之產生依賴於兩“臂”例如sdABD-TTA結構域之靶結合，其中一者在所述兩個構築體中之每一個上。如實例中所描述進行TDCC分析。 圖11顯示合適的半COBRA™對之示意圖。「Mep」代表穿膜肽酶蛋白酶裂解位點，「His-6」為本文所更全面地論述之標記物，ST14為間質蛋白酶蛋白酶裂解位點，且「Thb」為凝血酶蛋白酶裂解位點。 圖12A-圖12C顯示與圖11之構築體相關聯之TDCC資料。圖12A顯示添加預裂解的半COBRA對產生對OvCAR8細胞之效能，圖12B顯示添加預裂解的半COBRA對產生對HCT116細胞之效能，且圖12C顯示添加預裂解的半COBRA對產生對LoVo細胞之效能，所以此等效能均為癌細胞株。 圖13A-圖13B顯示MMP9連接子為活體內穩定的。經由尾靜脈以0.5 mg/kg之劑量向NSG小鼠投予單次靜脈內推注劑量的Pro40(MMP9可裂解)、Pro74(不可裂解)。在具有25 mM檸檬酸、75 mM L-精胺酸、75 mM NaCl及4%蔗糖pH 7.0之載劑中製備每種化合物之劑量溶液。在每種動物之預選時間處收集兩個血液樣品，一者在研究開始藉由眼眶放血或頜下腺放血收集，且另一者在終端時間點藉由心臟穿刺收集。血液收集之時間點為0.083、1、6、24、72及168小時。使用K 2EDTA管由每個單獨的血液樣品製備血漿。濃度係使用MSD分析用對抗HSA sdABD具有特異性之MAb來確定且用EGFR細胞外結構域來偵測。 圖14描繪圖15中所描繪之實驗中使用的格式3A半COBRA™構築體之示意圖。Pro51為陽性對照物，因為其「始終在線」，因為其形成活性抗CD3 Fv。Pro98為陰性對照物，因為其之sdABD係針對不藉由腫瘤表現之雞蛋溶菌酶(hen egg lysozyme)。Pro77及Pro53為使用針對EGFR之sdABD及MMP9裂解位點之前驅藥格式3A對。Pro74及Pro72為陰性對照格式3A對，因為其不具有裂解位點。 圖15顯示格式1構築體使用用實例中之協定植入至小鼠中之兩種不同的腫瘤細胞株使活體內腫瘤消退。具有半COBRA構築體(Pro77及Pro53)之抗腫瘤活性依賴於包含抗EGFR sdABD及MMP9可裂解連接子以及活性抗CD3 Fv。 圖16顯示下一代格式亦即具有裂解位點於其間之兩個假Fv結構域之全長構築體的示意圖，如在US 2018/0134789中一般所描述，其以引用的方式併入此處。然而，如下圖所示，此第一代全長構築體不顯示極好的條件性，因為其可異構化以形成活性及非活性構築體。 圖17表明格式3A構築體對比Pro100第一代全長構築體實際上顯示出更好的條件。 圖18描繪在圖19中測試之額外的第一代之全長構築體。 圖19顯示第一代構築體顯示即使在未裂解格式中之高活性，例如較差的條件性。 圖20顯示第一代全長構築體顯示分析性SEC上之兩種單體峰。 圖21顯示非裂解活性之理由的示意圖，所述理由為全長第一代構築體進行異構化以形成兩個構形，其中一者為非活性的，因為未形成活性抗CD3 Fv(「二價scFv」)，且另一者在不存在蛋白酶之情況下為活性「單鏈雙抗體」類型的構形。參見PEDS 23(8)：667-677(2010)。 圖22顯示在37℃下運行2天之在第一代單鏈構築體之情況下之TDCC分析的結果。所述結果顯示未裂解構築體顯示出強殺傷。此等結果引起Format 1構築體之生成。 圖23A-圖23G顯示本發明中使用之格式1構築體。如本領域技術人員所應瞭解及本文中所描述，此等者經sdABD-EGFR靶向部分描繪，但可使用針對其他TTA之sdABD。 圖24顯示格式1構築體(在此情況下Pro140)形成在37℃下穩定之單異構體。 圖25描繪如藉由八位元組分析所量測之格式1構築體具有呈未裂解格式之極低的針對人類CD3之結合。頂線為Pro120，中間線為Pro51(陽性對照物)，且底線為Pro140，其在4℃或37℃下保持3天。 圖26類似地描繪在格式1構築體具有呈未裂解形式之極低的TDCC活性。 圖27描繪用於活體內測試之使用作為靶向部分之sdABD-EGFR及MMP9裂解位點之特異性格式1構築體Pro140。 圖28A-圖28B顯示使用格式1構築體之腫瘤消退。 圖29描繪由於限制性Fv中之裂解位點，可生成幾種不同的片段：部分裂解的片段及完全裂解的片段。意外地，部分裂解的格式比完全裂解的格式更具有活性，引起格式2之生成。 圖30顯示多個格式2示意圖，所有此等物均使用sdABD-EGFR靶向結構域，但如本文所概述及序列中所列舉，可使用針對其他TTA之sdABD。Pro51及Pro201均為陽性對照物(呈活性「半」組態)，且Pro214為全長陰性對照物，因為不存在裂解位點。 圖31顯示使用穿膜肽酶裂解位點之格式2構築體Pro187之TDCC活性。在TDCC分析中，在添加預裂解Pro187時的活性比添加未裂解Pro187時的活性高1200倍。預裂解Pro187表現出落在陽性對照物Pro51與Pro201之間的活性。未裂解Pro187顯示出與不含有蛋白酶可裂解連接子之Pro214的活性類似的活性。 圖32顯示使用n MMP9裂解位點之格式2構築體Pro186之TDCC活性。在TDCC分析中，在添加預裂解Pro186時的活性比添加未裂解Pro186時的活性高18倍。預裂解Pro186顯示出落在陽性對照物Pro51與Pro201之間的活性。未裂解Pro186比不含有蛋白酶可裂解連接子之Pro214表現出更高的活性。 圖33描繪Pro186構築體結合至具有不同量之EGFR受體之細胞且CHO細胞不在細胞表面上表現EGFR。Pro186使表現呈類似COBRA濃度之不同量之EGFR的細胞飽和化。 圖34顯示圖35之活體內研究中使用之格式2構築體之示意圖，所有此等物均使用sdABD-EGFR靶向結構域。 圖35顯示在兩種濃度下之格式2構築體Pro186均為高度有效的，且比在較低濃度下之格式1構築體Pro140更好。 圖36描繪多個基於Pro186但具有不同的蛋白酶裂解位點之格式2構築體。雖然所有此等構築體均將sdABD-EGFR用於兩個靶向結構域，但可使用針對不同的TTA之其他sdABD，且其可為相同或不同的。亦即可進行同源靶向(均將sdABD靶向相同的TTA)或異源靶向(一個sdABD靶向第一TTA，且另一個靶向不同的TTA)。 圖37描繪改變Fv結構域之間的連接子長度之不同格式2構築體之示意圖。此等物顯示使用MMP9裂解位點，但其他可如本文所概述來使用。類似地，雖然所有此等構築體均將sdABD-EGFR用於兩個靶向結構域，但可使用針對不同的TTA之其他sdABD，且其可為相同或不同的。 圖38顯示假Fv之連接子長度可變化，例如具有活性Fv(「短活性」)之間的短連接子且具有假Fv(「長非活性」)之間的較長連接子之格式2構築體展現出與具有「短非活性」之「短活性」類似的活性。因此，COBRA構築體之條件性不依賴於活性及非活性之限制性scFv連接子；只要其中一者受到限制，則單鏈雙抗體折迭似乎比二價scFv折迭更有利。 圖39顯示活性Fv之連接子長度可變化，例如具有「長活性」及「短非活性」之格式2構築體之行為類似於「短活性」及「短非活性」構築體之行為。因此，COBRA構築體之條件性不依賴於活性及非活性之限制性scFv連接子；只要其中一者受到限制，則單鏈雙抗體折迭似乎比二價scFv折迭更有利。 圖40A-圖40C顯示多個不同構築體之示意圖。Pro188為除了具有假Fv中之長連接子(16聚體)之外與Pro140類似之格式1構築體。Pro189及Pro190(格式2構築體)類似於Pro186及Pro187，除了具有假Fv結構域中之長連接子(16聚體)。Pro191及Pro192(同樣地格式2構築體)類似於Pro189及Pro190，除了其在sdABD(1/2)上游具有另外的裂解位點。Pro193(格式4)具有單EGFR靶向結構域、進行重排以呈反向順序之iVH及iVL及sdABD(1/2)上游之另外的裂解位點。Pro195為類似於Pro186之格式2構築體且具有結合至相同的TTA、EGFR但結合至不同的表位之靶向結構域。Pro196、Pro197及Pro198為具有重排可變結構域之格式2構築體。 圖41描繪針對人類FOLR1之不同的sdABD選殖株顯示微分殺傷之事實。將結合至人類FOLR1之Pro22類型的構築體(具有FLAG序列而非NCL之Pro51)與針對多個細胞株家族之Pro22-EGFR構築體進行比較。 圖42描繪四個sdABD-FOLR1構築體之示意圖，其包含使用用sdABD-EGFR2(具有兩個分子進行分子間締合以形成針對CD3之兩種活性Fv)之Pro201陽性對照及兩個格式2測試物品(使用h77.2 sdABD之Pro311及使用h59.3 sdABD之Pro312)以及兩個陰性對照物(使用h77.2 sdABD之Pro299及使用h59.3 sdABD之Pro303)。 圖43描繪用於活體內設計之FOLR/MMP9之格式2構築體之示意圖。 圖44顯示活體內Pro312構築體之效能且證實MMP9可裂解連接子對於抗腫瘤活性必不可少 。圖45描繪使用針對人類B7H3之sdABD(sdABD-B7H3)之一些格式之示意圖，其包含陽性對照物Pro244(使用sdABD-B7H3(hF7)(具有兩個分子進行分子間締合以形成兩個針對CD3之活性Fv)及兩個格式2測試物品(格式2構築體Pro225及缺乏裂解位點之陰性對照物Pro295)。 圖46顯示Pro225具有與對照物Pro295相比之較大的條件性。 圖47顯示使用穿膜肽酶連接子之格式2構築體Pro373顯示與Pro295相比之較大的條件性。 圖48描繪多個sdABD-B7H3(使用hF12序列)構築體，其顯示使用sdABD-EGFR之Pro51陽性對照物、使用sdABD-hF12 B7H3之Pro244陽性對照物、測試構築體Pro226及不具有裂解位點之陰性對照物Pro296。 圖49顯示TDCC分析中之Pro226構築體之良好的條件性。 圖50顯示針對人類EpCAM之sdABD之人類化。 圖51顯示多個格式之示意圖：Pro22hVIB13及Pro205為陽性對照物，Pro199為格式2構築體且Pro175為陰性對照物。 圖52顯示sdABD-EpCAM構築體之TDCC活性，其顯示良好的條件性。 圖53A-圖53B顯示sdABD-EpCAM Pro199構築體之TDCC活性，其顯示HT29及LoVo細胞模型中之良好的條件性。 圖54A-圖54B顯示sdABD-EpCAM Pro200構築體之TDCC活性，其顯示HT29及LoVo細胞模型中之良好的條件性。 圖55顯示與Pro199相比具有雙重EpCAM sdABD之使用兩種不同的sdABD-TTA之Pro255之示意圖，一者針對EGFR(sdABD-EGFR)且另一者針對EpCAM(sdABD-EpCAM之)。此等物有時在本文中稱為「異源靶向」構築體，在此情況下為格式2構築體。 圖56顯示具有MMP9裂解位點之Pro255雙重靶向分子顯示良好的條件性。 圖57A-圖57D顯示三種不同的細胞類型上之實驗結果。首先，用類似表現量的EpCAM、EGFR及EpCAM + EGFR(資料未顯示)產生Raji轉染子。接著使用每種細胞類型在TDCC分析中測試靶向EpCAM及EGFR之Pro255。圖57A顯示不表現任一受體之親代Raji株。圖57B顯示對EpCAM株之條件性。圖57C顯示對EGRF株之條件性。圖57D顯示對EpCAM/EGFR株之條件性。 圖58描繪格式4構築體Pro258之示意圖。 圖59A-圖59B顯示Pro258在FBS及人類血清中具有條件性。由於培養物中之MMP9活性，MMP9連接子之條件性受到低估。引人注意地為，Pro51 TDCC活性受HSA結合抑制，而Pro258 TDCC活性在HSA存在之情況下與Pro51 TDCC活性相似。最後，在存在HSA乘以6倍之情況下，Pro258條件性在某種程度上有所增強。 圖60A-圖60C顯示藉由其他MMP之MMP9基質之裂解。 圖61A-圖61B顯示一些例示性構築體及其格式。 圖62A-圖62U顯示本發明之多個序列，但許多額外的序列亦在序列表中發現到。CDR加底線且加粗，連接子加雙底線(且可裂解連接子用斜體且加雙底線)以及結構域分離由「/」表示。所有His6標記物均為視情況選用的，因為其可用於降低人類中之免疫原性以及成為純化標記物。 
<![CDATA[<110>  日商武田藥品工業股份有限公司(TAKEDA PHARMACEUTICAL COMPANY LIMITED)]]>
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          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-FOLR1 h77-2]]>
          <![CDATA[<400>  18]]>
          Gly Phe Thr Val Ser Asn Ser Val Met Ala 
          1               5                   10  
          <![CDATA[<210>  19]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-FOLR1 h77-2]]>
          <![CDATA[<400>  19]]>
          Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys Gly 
          1               5                   10                  15      
          <![CDATA[<210>  20]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-FOLR1 h77-2]]>
          <![CDATA[<400>  20]]>
          Asn Phe Asp Arg Ile Tyr 
          1               5       
          <![CDATA[<210>  21]]>
          <![CDATA[<211>  113]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-FOLR1 ]]>
                 h59.3
          <![CDATA[<400>  21]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser 
          <![CDATA[<210>  22]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-FOLR1 h59.3]]>
          <![CDATA[<400>  22]]>
          Gly Asn Thr Phe Ser Ile Ser Ala Met Gly 
          1               5                   10  
          <![CDATA[<210>  23]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-FOLR1 h59.3]]>
          <![CDATA[<400>  23]]>
          Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
          1               5                   10                  15      
          <![CDATA[<210>  24]]>
          <![CDATA[<211]]>>  5]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt;  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成 sdCDR3 -靶sdAbs - α-FOLR1 h59.3]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  24]]&gt;
          <br/>
          <br/><![CDATA[Tyr Gly Ile Asp Tyr 
          1               5   
          <![CDATA[<210>  25]]>
          <![CDATA[<211>  117]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-FOLR1 ]]>
                 h22-4
          <![CDATA[<400>  25]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser 
                  115         
          <![CDATA[<210>  26]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-FOLR1 h22-4]]>
          <![CDATA[<400>  26]]>
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly 
          1               5                   10  
          <![CDATA[<210>  27]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-FOLR1 h22-4]]>
          <![CDATA[<400>  27]]>
          Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
          1               5                   10                  15      
          <![CDATA[<210>  28]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-FOLR1 h22-4]]>
          <![CDATA[<400>  28]]>
          Asn Thr Ala Thr Trp Gly Arg Val Phe 
          1               5                   
          <![CDATA[<210>  29]]>
          <![CDATA[<211>  124]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-B7H3 ]]>
                 hF7
          <![CDATA[<400>  29]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 
          <![CDATA[<210>  30]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-B7H3 hF7]]>
          <![CDATA[<400>  30]]>
          Arg Arg Thr Phe His Thr Tyr His Met Gly 
          1               5                   10  
          <![CDATA[<210>  31]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-B7H3 hF7]]>
          <![CDATA[<400>  31]]>
          Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  32]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-B7H3 hF7]]>
          <![CDATA[<400>  32]]>
          Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr 
          1               5                   10                  15  
          <![CDATA[<210>  33]]>
          <![CDATA[<211>  122]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-B7H3 ]]>
                 hF12
          <![CDATA[<400>  33]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120         
          <![CDATA[<210>  34]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-B7H3 hF12]]>
          <![CDATA[<400>  34]]>
          Pro Arg Thr Phe Ser Thr Tyr Ser Met Ala 
          1               5                   10  
          <![CDATA[<210>  35]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-B7H3 hF12]]>
          <![CDATA[<400>  35]]>
          Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  36]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-B7H3 hF12]]>
          <![CDATA[<400>  36]]>
          Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr 
          1               5                   10              
          <![CDATA[<210>  37]]>
          <![CDATA[<211>  122]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-EpCAM ]]>
                 h13
          <![CDATA[<400>  37]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120         
          <![CDATA[<210>  38]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-EpCAM h13]]>
          <![CDATA[<400>  38]]>
          Gly Thr Gly Ser Ile Phe Ser Ile Asn Leu Met Gly 
          1               5                   10          
          <![CDATA[<210>  39]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-EpCA]]>M h13
          <![CDATA[<400>  39]]>
          Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
          1               5                   10                  15      
          <![CDATA[<210>  40]]>
          <![CDATA[<211>  12]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-EpCAM h13]]>
          <![CDATA[<400>  40]]>
          Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr 
          1               5                   10          
          <![CDATA[<210>  41]]>
          <![CDATA[<211>  122]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 -靶sdAbs - α-EpCAM ]]>
                 h23
          <![CDATA[<400>  41]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120         
          <![CDATA[<210>  42]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 -靶sdAbs - α-EpCAM h23]]>
          <![CDATA[<400>  42]]>
          Gly Ser Phe Ser Ala Leu Trp Ala Met Arg 
          1               5                   10  
          <![CDATA[<210>  43]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 -靶sdAbs - α-EpCAM h23]]>
          <![CDATA[<400>  43]]>
          Ser Ser Arg Gly Gly Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly 
          1               5                   10                  15  
          <![CDATA[<210>  44]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 -靶sdAbs - α-EpCAM h23]]>
          <![CDATA[<400>  44]]>
          Ile Asp Gly His Leu Ala Tyr 
          1               5           
          <![CDATA[<210>  45]]>
          <![CDATA[<211>  115]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-HSA半衰期延長結構域]]>
          <![CDATA[<400>  45]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
                      20                  25                  30          
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
                      100                 105                 110         
          Val Ser Ser 
                  115 
          <![CDATA[<210>  46]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR1 - α-HSA半衰期延長結構域]]>
          <![CDATA[<400>  46]]>
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
          1               5                   10  
          <![CDATA[<210>  47]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR2 - α-HSA半衰期延長結構域]]>
          <![CDATA[<400>  47]]>
          Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys 
          1               5                   10                  15      
          Gly 
          <![CDATA[<210>  48]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 sdCDR3 - α-HSA半衰期延長結構域]]>
          <![CDATA[<400>  48]]>
          Gly Gly Ser Leu Ser Val 
          1               5       
          <![CDATA[<210>  49]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv 結構域 - ]]>
                 α-CD3V(L)
          <![CDATA[<400>  49]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  50]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 aVLCDR1 - α CD3 scFV 結構域 - α-CD3 V(L)]]>
          <![CDATA[<400>  50]]>
          Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  51]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 aVLsdCDR2 - α CD3 scFV 結構域 - α-CD3 V(L)]]>
          <![CDATA[<400>  51]]>
          Gly Thr Lys Phe Leu Val Pro 
          1               5           
          <![CDATA[<210>  52]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 aVLsdCDR3 - α CD3 scFV 結構域 - α-CD3 V(L)]]>
          <![CDATA[<400>  52]]>
          Thr Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  53]]>
          <![CDATA[<211>  110]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv 結構域 - ]]>
                 α-CD3V(Li)
          <![CDATA[<400>  53]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg 
              50                  55                  60                  
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
          65                  70                  75                  80  
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
                          85                  90                  95      
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 110 
          <![CDATA[<210>  54]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLCDR1 - α CD3 scFV 結構域 - α-CD3 V(Li)]]>
          <![CDATA[<400>  54]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  55]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLsdCDR2 - α CD3 scFV 結構域 - α-CD3 V(Li)]]>
          <![CDATA[<400>  55]]>
          Asp Tyr Lys Asp Asp Asp Asp Lys 
          1               5               
          <![CDATA[<210>  56]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLsdCDR3 - α CD3 scFV 結構域 - α-CD3 V(Li)]]>
          <![CDATA[<400>  56]]>
          Val Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  57]]>
          <![CDATA[<211>  109]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv 結構域 - ]]>
                 α-CD3V(Li2)
          <![CDATA[<400>  57]]>
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
          1               5                   10                  15      
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
                      20                  25                  30          
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                  35                  40                  45              
          Leu Ile Gly Gly Thr Lys Asp Asp Ala Pro Gly Thr Pro Ala Arg Phe 
              50                  55                  60                  
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
          65                  70                  75                  80  
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                          85                  90                  95      
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                      100                 105                 
          <![CDATA[<210>  58]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLCDR1 - α CD3 scFV 結構域 - α-CD3 V(Li2)]]>
          <![CDATA[<400>  58]]>
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          1               5                   10                  
          <![CDATA[<210>  59]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLCDR2 - α CD3 scFV 結構域 - α-CD3 V(Li2)]]>
          <![CDATA[<400>  59]]>
          Gly Thr Lys Asp Asp Ala Pro 
          1               5           
          <![CDATA[<210>  60]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVLCDR3 - α CD3 scFV 結構域 - α-CD3 V(Li2)]]>
          <![CDATA[<400>  60]]>
          Val Leu Trp Tyr Ser Asn Arg Trp Val 
          1               5                   
          <![CDATA[<210>  61]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv]]> 結構域 - 
                 α-CD3V(H)
          <![CDATA[<400>  61]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
              50                  55                  60                  
          Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210]]>>  62]]&gt;
          <br/>&lt;![CDATA[&lt;211&gt;  10]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt;  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成 aVHCDR1 - α CD3 scFV 結構域 - α-CD3 V(H)]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  62]]&gt;
          <br/>
          <br/><![CDATA[Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          1               5                   10  
          <![CDATA[<210>  63]]>
          <![CDATA[<211>  19]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 aVHsdCDR2 - α CD3 scFV 結構域 - α-CD3 V(H)]]>
          <![CDATA[<400>  63]]>
          Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln 
          1               5                   10                  15      
          Val Lys Asp 
          <![CDATA[<210>  64]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 aVHsdCDR3 - α CD3 scFV 結構域 - α-CD3 V(H)]]>
          <![CDATA[<400>  64]]>
          His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  65]]>
          <![CDATA[<211>  126]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv 結構域 - ]]>
                 α-CD3V(Hi)
          <![CDATA[<400>  65]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              50                  55                  60                  
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          65                  70                  75                  80  
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          85                  90                  95      
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      100                 105                 110         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125     
          <![CDATA[<210>  66]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVHsdCDR1 - α CD3 scFV 結構域 - α-CD3 V(Hi)]]>
          <![CDATA[<400>  66]]>
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
          1               5                   10  
          <![CDATA[<210>  67]]>
          <![CDATA[<211>  20]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVHsdCDR2 - α CD3 scFV 結構域 - α-CD3 V(Hi)]]>
          <![CDATA[<400>  67]]>
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
          1               5                   10                  15      
          Ser Val Lys Asp 
                      20  
          <![CDATA[<210>  68]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVHsdCDR3 - α CD3 scFV 結構域 - α-CD3 V(Hi)]]>
          <![CDATA[<400>  68]]>
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  69]]>
          <![CDATA[<211>  125]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-CD3 scFv 結構域 - ]]>
                 α-CD3V(Hi2)
          <![CDATA[<400>  69]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys His 
                      20                  25                  30          
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Ala Tyr Ala Asp 
              50                  55                  60                  
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          65                  70                  75                  80  
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          85                  90                  95      
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      100                 105                 110         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  115                 120                 125 
          <![CDATA[<210>  70]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVHsdCDR1 - α CD3 scFV 結構域 - α-CD3 V(Hi2)]]>
          <![CDATA[<400>  70]]>
          Gly Phe Thr Phe Asn Lys His Ala Met Asn 
          1               5                   10  
          <![CDATA[<21]]>0>  71]]&gt;
          <br/>&lt;![CDATA[&lt;211&gt;  19]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt;  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成 iVHsdCDR2 - α CD3 scFV 結構域 - α-CD3 V(Hi2)]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  71]]&gt;
          <br/>
          <br/><![CDATA[Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Ala Tyr Ala Asp Ser 
          1               5                   10                  15      
          Val Lys Asp 
          <![CDATA[<210>  72]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成 iVHsdCDR3 - α CD3 scFV 結構域 - α-CD3 V(Hi2)]]>
          <![CDATA[<400>  72]]>
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          1               5                   10                  
          <![CDATA[<210>  73]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成連接子 - α-CD3 scFV -正常，不可裂解的]]>
          <![CDATA[<400>  73]]>
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  74]]>
          <![CDATA[<211>  0]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成連接子 - α-CD3 scFV - 限制性]]>
          <![CDATA[<400>  74]]>
          000
          <![CDATA[<210>  75]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP 2/9]]>
          <![CDATA[<400>  75]]>
          Gly Pro Ala Gly Met Lys Gly Leu 
          1               5               
          <![CDATA[<210>  76]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP 2]]>/9
          <![CDATA[<400>  76]]>
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  77]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP 2/9]]>
          <![CDATA[<400>  77]]>
          Ser Gly Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Gly 
          1               5                   10                  15      
          Ser 
          <![CDATA[<210>  78]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 穿膜肽酶A/B]]>
          <![CDATA[<400>  78]]>
          Gly Gly Gly Gly Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  79]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 穿膜肽酶A/B]]>
          <![CDATA[<400>  79]]>
          Lys Lys Leu Ala Asp Glu Pro Glu 
          1               5               
          <![CDATA[<210>  80]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 穿膜肽酶A/B (變異體，高效率)]]>
          <![CDATA[<400>  80]]>
          Gly Gly Gly Lys Phe Leu Ala Asp Glu Pro Glu Gly Gly 
          1               5                   10              
          <![CDATA[<210>  81]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 組織蛋白酶 S,K,L]]>
          <![CDATA[<400>  81]]>
          Ser Gly Gly Gly Ala Arg Leu Gln Ser Ala Ala Pro Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  82]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 組織蛋白酶 S,K,L]]>
          <![CDATA[<400>  82]]>
          Ala Arg Leu Gln Ser Ala Ala Pro 
          1               5               
          <![CDATA[<210>  83]]>
          <![CDATA[<211>  18]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 穿膜肽酶/粒酶B]]>
          <![CDATA[<400>  83]]>
          Ser Gly Gly Gly Gly Val Tyr Ala Asp Ser Leu Glu Asp Gly Gly Gly 
          1               5                   10                  15      
          Gly Ser 
          <![CDATA[<210>  84]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 穿膜肽酶/粒酶B]]>
          <![CDATA[<400>  84]]>
          Gly Val Tyr Ala Asp Ser Leu Glu Asp Gly 
          1               5                   10  
          <![CDATA[<210>  85]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 間質蛋白酶/uPA (MS)]]>
          <![CDATA[<400>  85]]>
          Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  86]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 間質蛋白酶/uPA (MS)]]>
          <![CDATA[<400>  86]]>
          Gly Leu Ser Gly Arg Ser Asp Asn His Gly 
          1               5                   10  
          <![CDATA[<210>  87]]>
          <![CDATA[<211>  17]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 間質蛋白酶 (MV)]]>
          <![CDATA[<400>  87]]>
          Ser Gly Gly Gly Ser Phe Thr Arg Gln Ala Arg Val Val Gly Gly Gly 
          1               5                   10                  15      
          Ser 
          <![CDATA[<210>  88]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 間質蛋白酶 (MV)]]>
          <![CDATA[<400>  88]]>
          Ser Phe Thr Arg Gln Ala Arg Val Val 
          1               5                   
          <![CDATA[<210>  89]]>
          <![CDATA[<211>  14]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 組織蛋白酶S/MMP9/穿膜肽酶A]]>
          <![CDATA[<400>  89]]>
          Ala Arg Leu Gln Ser Ala Ala Pro Ala Gly Leu Lys Gly Ala 
          1               5                   10                  
          <![CDATA[<210>  90]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP9 (變異體，低效率)]]>
          <![CDATA[<40]]>0>  90]]&gt;
          <br/>
          <br/><![CDATA[Gly Gly Pro Gly Pro Ala Gly Met His Gly Leu Pro Gly 
          1               5                   10              
          <![CDATA[<210>  91]]>
          <![CDATA[<211>  13]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP9 (變異體，低效率)]]>
          <![CDATA[<400>  91]]>
          Gly Gly Pro Gly Pro Ala Gly Met Glu Gly Leu Pro Gly 
          1               5                   10              
          <![CDATA[<210>  92]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 凝血酶1]]>
          <![CDATA[<400>  92]]>
          Gly Gly Gly Gly Leu Val Pro Arg Gly Ser Leu Gly Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  93]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 凝血酶2]]>
          <![CDATA[<400>  93]]>
          Ser Ser Gly Gly Gly Met Pro Arg Ser Phe Arg Gly Gly Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  94]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - 腸激酶/F]]>lag
          <![CDATA[<400>  94]]>
          Gly Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  95]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - KLK7-6]]>
          <![CDATA[<400>  95]]>
          Ser Gly Gly Gly Gln Asn Pro Tyr Ser Ala Gly Arg Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  96]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - KLK7-13]]>
          <![CDATA[<400>  96]]>
          Ser Gly Gly Gly Gln Asn Pro Tyr Ser Ala Gly Gly Gly Ser Gly Gly 
          1               5                   10                  15      
          <![CDATA[<210>  97]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - KLK7-11]]>
          <![CDATA[<400>  97]]>
          Ser Gly Gly Gly Arg Asn Val Tyr Ser Ala Gly Gly Gly Ser Gly Gly 
          1               5                   10                  15      
          <![CDATA[<210>  98]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  ]]>人工序列
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - KLK7-10]]>
          <![CDATA[<400>  98]]>
          Ser Gly Gly Gly Gln Asn Thr Trp Ser Ala Gly Lys Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  99]]>
          <![CDATA[<211>  16]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - uPA]]>
          <![CDATA[<400>  99]]>
          Gly Gly Gly Ser His Thr Gly Arg Ser Ala Tyr Phe Gly Gly Gly Ser 
          1               5                   10                  15      
          <![CDATA[<210>  100]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP7]]>
          <![CDATA[<400>  100]]>
          Lys Arg Ala Leu Gly Leu Pro Gly 
          1               5               
          <![CDATA[<210>  101]]>
          <![CDATA[<211>  24]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP7]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (1)..(8)]]>
          <![CDATA[<223>  X 可為 Asp 或 Glu]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (17)..(24)]]>
          <![CDATA[<223>  X 可為 Asp 或 Arg]]>
          <![CDATA[<400>  101]]>
          Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Pro Leu Ala Leu Trp Arg Ser 
          1               5                   10                  15      
          Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                      20                  
          <![CDATA[<210>  102]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP9]]>
          <![CDATA[<400>  102]]>
          Pro Arg Ser Thr Leu Ile Ser Thr 
          1               5               
          <![CDATA[<210>  103]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP9]]>
          <![CDATA[<400>  103]]>
          Leu Glu Ala Thr Ala 
          1               5   
          <![CDATA[<210>  104]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP11]]>
          <![CDATA[<400>  104]]>
          Gly Gly Ala Ala Asn Leu Val Arg Gly Gly 
          1               5                   10  
          <![CDATA[<210>  105]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220]]>>]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成蛋白酶裂解位點 - MMP14]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  105]]&gt;
          <br/>
          <br/><![CDATA[Ser Gly Arg Ile Gly Phe Leu Arg Thr Ala 
          1               5                   10  
          <![CDATA[<210>  106]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<400>  106]]>
          Pro Leu Gly Leu Ala Gly 
          1               5       
          <![CDATA[<210>  107]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (6)..(6)]]>
          <![CDATA[<223>  Xaa可為任何天然存在之胺基酸]]>
          <![CDATA[<400>  107]]>
          Pro Leu Gly Leu Ala Xaa 
          1               5       
          <![CDATA[<210>  108]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<400>  108]]>
          Pro Leu Gly Cys Met Glu Ala Gly 
          1               5               
          <![CDATA[<210>  109]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<400>  109]]>
          Glu Ser Pro Ala Tyr Tyr Thr Ala 
          1               5               
          <![CDATA[<210>  110]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>]]>  人工序列
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<400>  110]]>
          Arg Leu Gln Leu Lys Leu 
          1               5       
          <![CDATA[<210>  111]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP]]>
          <![CDATA[<400>  111]]>
          Arg Leu Gln Leu Lys Ala Cys 
          1               5           
          <![CDATA[<210>  112]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - MMP2, MMP9, MMP14]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (1)..(3)]]>
          <![CDATA[<223>  X 可為 Cys 或 Ile 或 Thr]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (5)..(5)]]>
          <![CDATA[<223>  X 可為 His 或 Orn 或 Phe]]>
          <![CDATA[<400>  112]]>
          Glu Pro Xaa Gly Xaa Tyr Leu 
          1               5           
          <![CDATA[<210>  113]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 尿激酶纖維蛋白溶酶原活化物 (upa)]]>
          <![CDATA[<400>  113]]>
          Ser Gly Arg Ser Ala 
          1               5   
          <![CDATA[<210>  114]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 尿激酶纖維蛋白溶酶原活化物 (upa)]]>
          <![CDATA[<400>  114]]>
          Asp Ala Phe Lys 
          1               
          <![CDATA[<210>  115]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 尿激酶纖維蛋白溶酶原活化物 (upa)]]>
          <![CDATA[<400>  115]]>
          Gly Gly Gly Arg Arg 
          1               5   
          <![CDATA[<210>  116]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 溶酶體酶]]>
          <![CDATA[<400>  116]]>
          Gly Phe Leu Gly 
          1               
          <![CDATA[<210>  117]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序]]>列
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 溶酶體酶]]>
          <![CDATA[<400>  117]]>
          Ala Leu Ala Leu 
          1               
          <![CDATA[<210>  118]]>
          <![CDATA[<211>  2]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 溶酶體酶]]>
          <![CDATA[<400>  118]]>
          Phe Lys 
          1       
          <![CDATA[<210>  119]]>
          <![CDATA[<211>  3]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 組織蛋白酶 B]]>
          <![CDATA[<400>  119]]>
          Asn Leu Leu 
          1           
          <![CDATA[<210>  120]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 組織蛋白酶 D]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (4)..(4)]]>
          <![CDATA[<223>  X 可為 Glu 或 Thr]]>
          <![CDATA[<400>  120]]>
          Pro Ile Cys Xaa Phe Phe 
          1               5       
          <![CDATA[<210>  121]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223]]>>  合成蛋白酶裂解位點 - 組織蛋白酶 K]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  121]]&gt;
          <br/>
          <br/><![CDATA[Gly Gly Pro Arg Gly Leu Pro Gly 
          1               5               
          <![CDATA[<210>  122]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 前列腺特異性抗原]]>
          <![CDATA[<400>  122]]>
          His Ser Ser Lys Leu Gln 
          1               5       
          <![CDATA[<210>  123]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 前列腺特異性抗原]]>
          <![CDATA[<400>  123]]>
          His Ser Ser Lys Leu Gln Leu 
          1               5           
          <![CDATA[<210>  124]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 前列腺特異性抗原]]>
          <![CDATA[<400>  124]]>
          His Ser Ser Lys Leu Gln Glu Asp Ala 
          1               5                   
          <![CDATA[<210>  125]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 單純皰疹病毒蛋白酶]]>
          <![CDATA[<400>  125]]>
          Leu Val Leu Ala Ser Ser Ser Phe Gly Tyr 
          1               5                   10  
          <![CDATA[<210>  126]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - Hiv 蛋白酶]]>
          <![CDATA[<400>  126]]>
          Gly Val Ser Gln Asn Tyr Pro Ile Val Gly 
          1               5                   10  
          <![CDATA[<210>  127]]>
          <![CDATA[<211>  10]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - Cmv 蛋白酶]]>
          <![CDATA[<400>  127]]>
          Gly Val Val Gln Ala Ser Cys Arg Leu Ala 
          1               5                   10  
          <![CDATA[<210>  128]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凝血酶]]>
          <![CDATA[<220>]]>
          <![CDATA[<221>  misc_feature]]>
          <![CDATA[<222>  (2)..(2)]]>
          <![CDATA[<223>  X 可為 Pro 或 Ile 或 Pro]]>
          <![CDATA[<400>  128]]>
          Phe Xaa Arg Ser 
          1               
          <![CDATA[<210>]]>  129
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凝血酶]]>
          <![CDATA[<400>  129]]>
          Asp Pro Arg Ser Phe Leu 
          1               5       
          <![CDATA[<210>  130]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凝血酶]]>
          <![CDATA[<400>  130]]>
          Pro Pro Arg Ser Phe Leu 
          1               5       
          <![CDATA[<210>  131]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凋亡蛋白酶-3]]>
          <![CDATA[<400>  131]]>
          Asp Glu Val Asp 
          1               
          <![CDATA[<210>  132]]>
          <![CDATA[<211>  5]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凋亡蛋白酶-3]]>
          <![CDATA[<400>  132]]>
          Asp Glu Val Asp Pro 
          1               5   
          <![CDATA[<210>  133]]>
          <![CDATA[<211>  8]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 凋亡蛋白酶-3]]>
          <![CDATA[<400>  133]]>
          Lys Gly Ser Gly Asp Val Glu Gly 
          1               5               
          <![CDATA[<210>  134]]>
          <![CDATA[<211]]>>  6]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt;  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成蛋白酶裂解位點 - 介白素-1β轉化酶]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  134]]&gt;
          <br/>
          <br/><![CDATA[Gly Trp Glu His Asp Gly 
          1               5       
          <![CDATA[<210>  135]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 腸激酶]]>
          <![CDATA[<400>  135]]>
          Glu Asp Asp Asp Asp Lys Ala 
          1               5           
          <![CDATA[<210>  136]]>
          <![CDATA[<211>  9]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - Fap]]>
          <![CDATA[<400>  136]]>
          Lys Gln Glu Gln Asn Pro Gly Ser Thr 
          1               5                   
          <![CDATA[<210>  137]]>
          <![CDATA[<211>  6]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 激肽釋放酶2]]>
          <![CDATA[<400>  137]]>
          Gly Lys Ala Phe Arg Arg 
          1               5       
          <![CDATA[<210>  138]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 纖維蛋白溶酶]]>
          <![CDATA[<400>  138]]>
          Asp Ala Phe Lys 
          1               
          <![CDATA[<210>  139]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 纖維蛋白溶酶]]>
          <![CDATA[<400>  139]]>
          Asp Val Leu Lys 
          1               
          <![CDATA[<210>  140]]>
          <![CDATA[<211>  4]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - 纖維蛋白溶酶]]>
          <![CDATA[<400>  140]]>
          Asp Ala Phe Lys 
          1               
          <![CDATA[<210>  141]]>
          <![CDATA[<211>  7]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成蛋白酶裂解位點 - Top]]>
          <![CDATA[<400>  141]]>
          Ala Leu Leu Leu Ala Leu Leu 
          1               5           
          <![CDATA[<210>  142]]>
          <![CDATA[<211>  121]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成抗原結合結構域 - α-HSA半衰期延長結構域]]>
          <![CDATA[<400>  142]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
                      20                  25                  30          
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  35                  40                  45              
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
                      100                 105                 110         
          Val Ser Ser His His His His His His 
                  115                 120     
          <![CDATA[<210>  143]]>
          <![CDATA[<211>  889]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro140 格式1]]>
          <![CDATA[<400>  143]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Pro Ala Gly Met Lys Gly Leu Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 
          <![CDATA[<210>  144]]>
          <![CDATA[<211>  890]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro140b 格式1]]>
          <![CDATA[<400>  144]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Lys Lys Leu Ala Asp Glu Pro Glu Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890 
          <![CDATA[<210>  145]]>
          <![CDATA[<211>  889]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro186 格式2]]>
          <![CDATA[<400>  145]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 
          <![CDATA[<210>  146]]>
          <![CDATA[<211>  890]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro187 格式2]]>
          <![CDATA[<400>  146]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890 
          <![CDATA[<210>  147]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  P]]>RT
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro225 (FL aB7H3 hF7 MMP9 連接子) 格式2]]>
          <![CDATA[<400>  147]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr His Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
                      420                 425                 430         
          Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895 
          <![CDATA[<210>  148]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro226 (FL aB7H3 hF12 MMP9 連接子) 格式2]]>
          <![CDATA[<400>  148]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr Ser Met Ala Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val Ala Ala Ile Asn 
                      420                 425                 430         
          Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Gly 
          465                 470                 475                 480 
          Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
                          485                 490                 495     
          Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
                      500                 505                 510         
          Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                  515                 520                 525             
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
              530                 535                 540                 
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
          545                 550                 555                 560 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
                          565                 570                 575     
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                      580                 585                 590         
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                  595                 600                 605             
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
              610                 615                 620                 
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
          625                 630                 635                 640 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                          645                 650                 655     
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                      660                 665                 670         
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                  675                 680                 685             
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
              690                 695                 700                 
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
          705                 710                 715                 720 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                          725                 730                 735     
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                      740                 745                 750         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  755                 760                 765             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              770                 775                 780                 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
          785                 790                 795                 800 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          805                 810                 815     
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                      820                 825                 830         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                  835                 840                 845             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
              850                 855                 860                 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
          865                 870                 875                 880 
          Val Thr Val Ser Ser His His His His His His 
                          885                 890     
          <![CDATA[<210>  149]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro233 (人類化Pro186) 格式2]]>
          <![CDATA[<400>  149]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895 
          <![CDATA[<210>  150]]>
          <![CDATA[<211>  875]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro311 (FL aFOLR1 h77.2 MMP9 連接子) 格式]]>
                 2
          <![CDATA[<400>  150]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              370                 375                 380                 
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          385                 390                 395                 400 
          Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala 
                      420                 425                 430         
          Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                  435                 440                 445             
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
              450                 455                 460                 
          Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr 
          465                 470                 475                 480 
          Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
                          485                 490                 495     
          Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                      500                 505                 510         
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                  515                 520                 525             
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
              530                 535                 540                 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
          545                 550                 555                 560 
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                          565                 570                 575     
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                      580                 585                 590         
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
                  595                 600                 605             
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
              610                 615                 620                 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
          625                 630                 635                 640 
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                          645                 650                 655     
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                      660                 665                 670         
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
                  675                 680                 685             
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
              690                 695                 700                 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
          705                 710                 715                 720 
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                          725                 730                 735     
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                      740                 745                 750         
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                  755                 760                 765             
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
              770                 775                 780                 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
          785                 790                 795                 800 
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                          805                 810                 815     
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                      820                 825                 830         
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                  835                 840                 845             
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
              850                 855                 860                 
          Val Thr Val Ser Ser His His His His His His 
          865                 870                 875 
          <![CDATA[<210>  151]]>
          <![CDATA[<211>  873]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro312 (FL aFOLR1 h59.3 MMP9 連接子)]]>
          <![CDATA[<400>  151]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              370                 375                 380                 
          Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe 
          385                 390                 395                 400 
          Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
                          405                 410                 415     
          Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp 
                      420                 425                 430         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                  435                 440                 445             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
              450                 455                 460                 
          Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
          465                 470                 475                 480 
          Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu 
                          485                 490                 495     
          Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                      500                 505                 510         
          Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
                  515                 520                 525             
          Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
              530                 535                 540                 
          Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr 
          545                 550                 555                 560 
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                          565                 570                 575     
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                      580                 585                 590         
          Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                  595                 600                 605             
          Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              610                 615                 620                 
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
          625                 630                 635                 640 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                          645                 650                 655     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                      660                 665                 670         
          Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe 
                  675                 680                 685             
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
              690                 695                 700                 
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
          705                 710                 715                 720 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
                          725                 730                 735     
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                      740                 745                 750         
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
                  755                 760                 765             
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
              770                 775                 780                 
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
          785                 790                 795                 800 
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
                          805                 810                 815     
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
                      820                 825                 830         
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                  835                 840                 845             
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
              850                 855                 860                 
          Val Ser Ser His His His His His His 
          865                 870             
          <![CDATA[<210>  152]]>
          <![CDATA[<211>  881]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro313 (FL aFOLR1 h22.4 MMP9 連接子) 格式]]>
                 2
          <![CDATA[<400>  152]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro 
                          485                 490                 495     
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr 
                      500                 505                 510         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  515                 520                 525             
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              530                 535                 540                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
          545                 550                 555                 560 
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          565                 570                 575     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      580                 585                 590         
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  595                 600                 605             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              610                 615                 620                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          625                 630                 635                 640 
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                          645                 650                 655     
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                      660                 665                 670         
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
                  675                 680                 685             
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
              690                 695                 700                 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
          705                 710                 715                 720 
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                          725                 730                 735     
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                      740                 745                 750         
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                  755                 760                 765             
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
              770                 775                 780                 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
          785                 790                 795                 800 
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                          805                 810                 815     
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                      820                 825                 830         
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                  835                 840                 845             
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
              850                 855                 860                 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
          865                 870                 875                 880 
          His 
          <![CDATA[<210>  153]]>
          <![CDATA[<211>  898]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro246 (具有MMP9 連接子之FL haEGFR1/haEGFR2 異源性 ]]>
                 COBRA)
          <![CDATA[<400>  153]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                      20                  25                  30          
          Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                      100                 105                 110         
          Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              130                 135                 140                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
          145                 150                 155                 160 
          Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro 
                          165                 170                 175     
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                      180                 185                 190         
          Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser 
                  195                 200                 205             
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
              210                 215                 220                 
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly 
          225                 230                 235                 240 
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                          245                 250                 255     
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      260                 265                 270         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  275                 280                 285             
          Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              290                 295                 300                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          305                 310                 315                 320 
          Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          325                 330                 335     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      340                 345                 350         
          Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  355                 360                 365             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              370                 375                 380                 
          Ser Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly 
          385                 390                 395                 400 
          Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser 
                          405                 410                 415     
          Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                      420                 425                 430         
          Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser 
                  435                 440                 445             
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
              450                 455                 460                 
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr 
          465                 470                 475                 480 
          Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr 
                          485                 490                 495     
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly 
                      500                 505                 510         
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val 
                  515                 520                 525             
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
              530                 535                 540                 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          545                 550                 555                 560 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                          565                 570                 575     
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                      580                 585                 590         
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                  595                 600                 605             
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
              610                 615                 620                 
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                          645                 650                 655     
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                      660                 665                 670         
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                  675                 680                 685             
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
              690                 695                 700                 
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
          705                 710                 715                 720 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                          725                 730                 735     
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                      740                 745                 750         
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760                 765             
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              770                 775                 780                 
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
          785                 790                 795                 800 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
                          805                 810                 815     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                      820                 825                 830         
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                  835                 840                 845             
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
              850                 855                 860                 
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
          865                 870                 875                 880 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
                          885                 890                 895     
          His His 
          <![CDATA[<210>  154]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro256 (FL haEpCAM VIB13/haEGFR1 ]]>
                 異源性 COBRA MMP9 連接子)
          <![CDATA[<400>  154]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Thr Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile Ser 
                      420                 425                 430         
          Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Ala Ala 
          465                 470                 475                 480 
          Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
          625                 630                 635                 640 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
                          645                 650                 655     
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                      660                 665                 670         
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                  675                 680                 685             
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  155]]>
          <![CDATA[<211>  885]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro420 (FL aFOLR1 h77.2/haEGFR1 ]]>
                 異源性 COBRA MMP9 連接子)
          <![CDATA[<400>  155]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val 
              370                 375                 380                 
          Arg Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr 
          385                 390                 395                 400 
          Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr 
                      420                 425                 430         
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  435                 440                 445             
          Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
              450                 455                 460                 
          Leu Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu 
          465                 470                 475                 480 
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          485                 490                 495     
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                      500                 505                 510         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  515                 520                 525             
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              530                 535                 540                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          545                 550                 555                 560 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                          565                 570                 575     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      580                 585                 590         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                  595                 600                 605             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              610                 615                 620                 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          625                 630                 635                 640 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                          645                 650                 655     
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                      660                 665                 670         
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
                  675                 680                 685             
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
              690                 695                 700                 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
          705                 710                 715                 720 
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                          725                 730                 735     
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                      740                 745                 750         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
                  755                 760                 765             
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
              770                 775                 780                 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
          785                 790                 795                 800 
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                          805                 810                 815     
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                      820                 825                 830         
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
                  835                 840                 845             
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
              850                 855                 860                 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
          865                 870                 875                 880 
          His His His His His 
                          885 
          <![CDATA[<210>  156]]>
          <![CDATA[<211>  885]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro421 (FL haEGFR1/aFOLR1 h77.2 ]]>
                 異源性 COBRA MMP9 連接子)
          <![CDATA[<400>  156]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser Val Met 
                          405                 410                 415     
          Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val Ala Ile 
                      420                 425                 430         
          Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn Arg Asn 
          465                 470                 475                 480 
          Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          485                 490                 495     
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                      500                 505                 510         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  515                 520                 525             
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              530                 535                 540                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          545                 550                 555                 560 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                          565                 570                 575     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      580                 585                 590         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                  595                 600                 605             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              610                 615                 620                 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          625                 630                 635                 640 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                          645                 650                 655     
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                      660                 665                 670         
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
                  675                 680                 685             
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
              690                 695                 700                 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
          705                 710                 715                 720 
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                          725                 730                 735     
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                      740                 745                 750         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
                  755                 760                 765             
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
              770                 775                 780                 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
          785                 790                 795                 800 
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                          805                 810                 815     
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                      820                 825                 830         
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
                  835                 840                 845             
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
              850                 855                 860                 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
          865                 870                 875                 880 
          His His His His His 
                          885 
          <![CDATA[<210>  157]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro393 (Pro186 S9 連接子)]]>
          <![CDATA[<400>  157]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala Arg Leu Gln Ser 
                      500                 505                 510         
          Ala Ala Pro Ala Gly Leu Lys Gly Ala Gly Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  158]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro394 (Pro186 ST14(MV) 連接子)]]>
          <![CDATA[<400>  158]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Phe Thr 
                      500                 505                 510         
          Arg Gln Ala Arg Val Val Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  159]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro395 (Pro186 CathS 連接子)]]>
          <![CDATA[<400>  159]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Ala Arg 
                      500                 505                 510         
          Leu Gln Ser Ala Ala Pro Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  160]]>
          <![CDATA[<211>  897]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro396 (Pro186 MMP9v 連接子)]]>
          <![CDATA[<400>  160]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Gly Pro Gly 
                      500                 505                 510         
          Pro Ala Gly Met His Gly Leu Pro Gly Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
                          565                 570                 575     
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                      580                 585                 590         
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                  595                 600                 605             
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
              610                 615                 620                 
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                          645                 650                 655     
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                      660                 665                 670         
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                  675                 680                 685             
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
              690                 695                 700                 
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
          705                 710                 715                 720 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                          725                 730                 735     
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                      740                 745                 750         
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  755                 760                 765             
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
              770                 775                 780                 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
          785                 790                 795                 800 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                          805                 810                 815     
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                      820                 825                 830         
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                  835                 840                 845             
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
              850                 855                 860                 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
          865                 870                 875                 880 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
                          885                 890                 895     
          His 
          <![CDATA[<210>  161]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro429 (Pro186 穿膜肽酶/粒酶B連接子)]]>
          <![CDATA[<400>  161]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Val Tyr 
                      500                 505                 510         
          Ala Asp Ser Leu Glu Asp Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  162]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro430 (Pro186 MMP9-2 連接子)]]>
          <![CDATA[<400>  162]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Leu Lys Gly Ala Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895 
          <![CDATA[<210>  163]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro431 (Pro186 ST14(MS) 連接子)]]>
          <![CDATA[<400>  163]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Leu Ser 
                      500                 505                 510         
          Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<21]]>0>  164]]&gt;
          <br/>&lt;![CDATA[&lt;211&gt;  763]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt;  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成構築體 - Pro258 (具有單aEGFR結構域及中央aHSA結構域之Pro186)]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  164]]&gt;
          <br/>
          <br/><![CDATA[Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
              370                 375                 380                 
          Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          385                 390                 395                 400 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                          405                 410                 415     
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                  435                 440                 445             
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
          465                 470                 475                 480 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      500                 505                 510         
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                  515                 520                 525             
          Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
              530                 535                 540                 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
          545                 550                 555                 560 
          Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala 
                          565                 570                 575     
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                      580                 585                 590         
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr 
                  595                 600                 605             
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
              610                 615                 620                 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
          625                 630                 635                 640 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                          645                 650                 655     
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                      660                 665                 670         
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
                  675                 680                 685             
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
              690                 695                 700                 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
          705                 710                 715                 720 
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                          725                 730                 735     
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                      740                 745                 750         
          Val Thr Val Ser Ser His His His His His His 
                  755                 760             
          <![CDATA[<210>  165]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro221 - 可裂解連接子變異體]]>
          <![CDATA[<400>  165]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Gln Asn 
                      500                 505                 510         
          Pro Tyr Ser Ala Gly Arg Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  166]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro222 - 可裂解連接子變異體]]>
          <![CDATA[<400>  166]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Gln Asn 
                      500                 505                 510         
          Pro Tyr Ser Ala Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  167]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro223 - 可裂解連接子變異體]]>
          <![CDATA[<400>  167]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Arg Asn 
                      500                 505                 510         
          Val Tyr Ser Ala Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  168]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro224- 可裂解連接子變異體]]>
          <![CDATA[<400>  168]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Gln Asn 
                      500                 505                 510         
          Thr Trp Ser Ala Gly Lys Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  169]]>
          <![CDATA[<211>  898]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro254- 異源性 格式2]]>
          <![CDATA[<400>  169]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Val Ala 
                      420                 425                 430         
          Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr Glu Tyr 
                          485                 490                 495     
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly 
                      500                 505                 510         
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val 
                  515                 520                 525             
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
              530                 535                 540                 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          545                 550                 555                 560 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                          565                 570                 575     
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                      580                 585                 590         
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                  595                 600                 605             
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
              610                 615                 620                 
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                          645                 650                 655     
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                      660                 665                 670         
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                  675                 680                 685             
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
              690                 695                 700                 
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
          705                 710                 715                 720 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                          725                 730                 735     
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                      740                 745                 750         
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760                 765             
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              770                 775                 780                 
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
          785                 790                 795                 800 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
                          805                 810                 815     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                      820                 825                 830         
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                  835                 840                 845             
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
              850                 855                 860                 
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
          865                 870                 875                 880 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
                          885                 890                 895     
          His His 
          <![CDATA[<210>  170]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro255- 異源性 格式2]]>
          <![CDATA[<400>  170]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
          625                 630                 635                 640 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
                          645                 650                 655     
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                      660                 665                 670         
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                  675                 680                 685             
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  171]]>
          <![CDATA[<211>  902]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro262]]>
          <![CDATA[<400>  171]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      260                 265                 270         
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                  275                 280                 285             
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
              290                 295                 300                 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
          305                 310                 315                 320 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
                          325                 330                 335     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      340                 345                 350         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                  355                 360                 365             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              370                 375                 380                 
          Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser 
          385                 390                 395                 400 
          Val Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg 
                          405                 410                 415     
          Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Glu Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly 
                  435                 440                 445             
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
          465                 470                 475                 480 
          Ala Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr 
                          485                 490                 495     
          Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                      500                 505                 510         
          Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser 
                  515                 520                 525             
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
              530                 535                 540                 
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
          545                 550                 555                 560 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                          565                 570                 575     
          Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg 
                      580                 585                 590         
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                  595                 600                 605             
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
              610                 615                 620                 
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              770                 775                 780                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
          785                 790                 795                 800 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
                          805                 810                 815     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                      820                 825                 830         
          Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg 
                  835                 840                 845             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
              850                 855                 860                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
          865                 870                 875                 880 
          Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 895     
          His His His His His His 
                      900         
          <![CDATA[<210>  172]]>
          <![CDATA[<211>  766]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro356 - 格式4]]>
          <![CDATA[<400>  172]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                      20                  25                  30          
          Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                      100                 105                 110         
          Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              130                 135                 140                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
          145                 150                 155                 160 
          Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro 
                          165                 170                 175     
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                      180                 185                 190         
          Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser 
                  195                 200                 205             
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
              210                 215                 220                 
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly 
          225                 230                 235                 240 
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                          245                 250                 255     
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      260                 265                 270         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  275                 280                 285             
          Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              290                 295                 300                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          305                 310                 315                 320 
          Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          325                 330                 335     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      340                 345                 350         
          Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  355                 360                 365             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly Pro Ala 
              370                 375                 380                 
          Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
          385                 390                 395                 400 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
                          405                 410                 415     
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                      420                 425                 430         
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                  435                 440                 445             
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
              450                 455                 460                 
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
          465                 470                 475                 480 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
                          485                 490                 495     
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                      500                 505                 510         
          Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                  515                 520                 525             
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
              530                 535                 540                 
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
          545                 550                 555                 560 
          Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
                          565                 570                 575     
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                      580                 585                 590         
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                  595                 600                 605             
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
              610                 615                 620                 
          Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
          625                 630                 635                 640 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
                          645                 650                 655     
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
                      660                 665                 670         
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                  675                 680                 685             
          Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg 
              690                 695                 700                 
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
          705                 710                 715                 720 
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
                          725                 730                 735     
          Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
                      740                 745                 750         
          Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                  755                 760                 765     
          <![CDATA[<210>  173]]>
          <![CDATA[<211>  763]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro359 - 格式4]]>
          <![CDATA[<400>  173]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
              370                 375                 380                 
          Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          385                 390                 395                 400 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                          405                 410                 415     
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                  435                 440                 445             
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
          465                 470                 475                 480 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      500                 505                 510         
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                  515                 520                 525             
          Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
              530                 535                 540                 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
          545                 550                 555                 560 
          Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala 
                          565                 570                 575     
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                      580                 585                 590         
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr 
                  595                 600                 605             
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
              610                 615                 620                 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
          625                 630                 635                 640 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                          645                 650                 655     
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                      660                 665                 670         
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
                  675                 680                 685             
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
              690                 695                 700                 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
          705                 710                 715                 720 
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                          725                 730                 735     
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                      740                 745                 750         
          Val Thr Val Ser Ser His His His His His His 
                  755                 760             
          <![CDATA[<210>  174]]>
          <![CDATA[<211>  752]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro364 - 格式4]]>
          <![CDATA[<400>  174]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly 
                  355                 360                 365             
          Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu 
              370                 375                 380                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
          385                 390                 395                 400 
          Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
                          405                 410                 415     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                      420                 425                 430         
          Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                  435                 440                 445             
          Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
              450                 455                 460                 
          Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
          465                 470                 475                 480 
          Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                          485                 490                 495     
          Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                      500                 505                 510         
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                  515                 520                 525             
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
              530                 535                 540                 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp 
          545                 550                 555                 560 
          Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          565                 570                 575     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      580                 585                 590         
          Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  595                 600                 605             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              610                 615                 620                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          625                 630                 635                 640 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          645                 650                 655     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      660                 665                 670         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  675                 680                 685             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              690                 695                 700                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          705                 710                 715                 720 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          725                 730                 735     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                      740                 745                 750         
          <![CDATA[<210>  175]]>
          <![CDATA[<211>  753]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro388 - 格式4]]>
          <![CDATA[<400>  175]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Pro 
                  355                 360                 365             
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val 
              370                 375                 380                 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
          385                 390                 395                 400 
          Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val 
                          405                 410                 415     
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                      420                 425                 430         
          Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr 
                  435                 440                 445             
          Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
              450                 455                 460                 
          Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
          465                 470                 475                 480 
          Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                          485                 490                 495     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      500                 505                 510         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
                  515                 520                 525             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              530                 535                 540                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
          545                 550                 555                 560 
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                          565                 570                 575     
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                      580                 585                 590         
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
                  595                 600                 605             
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              610                 615                 620                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
          625                 630                 635                 640 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                          645                 650                 655     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                      660                 665                 670         
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
                  675                 680                 685             
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
              690                 695                 700                 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
          705                 710                 715                 720 
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                          725                 730                 735     
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
                      740                 745                 750         
          His 
          <![CDATA[<210>  176]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro432- 異源性 - 格式2]]>
          <![CDATA[<400>  176]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Val Ala Ile Asn 
                      420                 425                 430         
          Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Tyr 
          465                 470                 475                 480 
          Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr Glu Tyr Asp Tyr 
                          485                 490                 495     
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly 
                      500                 505                 510         
          Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  177]]>
          <![CDATA[<211>  636]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro448- 雙重靶半格式]]>3
          <![CDATA[<400>  177]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Val 
                  115                 120                 125             
          Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Thr Leu Ser 
              130                 135                 140                 
          Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe 
          145                 150                 155                 160 
          Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile Ser Trp 
                          165                 170                 175     
          Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
                  195                 200                 205             
          Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Ala Ala Gly 
              210                 215                 220                 
          Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                          245                 250                 255     
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                      260                 265                 270         
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                  275                 280                 285             
          Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
              290                 295                 300                 
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
          305                 310                 315                 320 
          Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                          325                 330                 335     
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                      340                 345                 350         
          Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                  355                 360                 365             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly 
              370                 375                 380                 
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val 
          385                 390                 395                 400 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                          405                 410                 415     
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                      420                 425                 430         
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                  435                 440                 445             
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
              450                 455                 460                 
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
          465                 470                 475                 480 
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                          485                 490                 495     
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  515                 520                 525             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              530                 535                 540                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          545                 550                 555                 560 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          565                 570                 575     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      580                 585                 590         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  595                 600                 605             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              610                 615                 620                 
          Leu Val Thr Val Ser Ser His His His His His His 
          625                 630                 635     
          <![CDATA[<210>  178]]>
          <![CDATA[<211>  636]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro449 雙重靶半格式3]]>
          <![CDATA[<400>  178]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  115                 120                 125             
          Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              130                 135                 140                 
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          145                 150                 155                 160 
          Thr Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn 
                          165                 170                 175     
          Glu Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr 
                      180                 185                 190         
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                  195                 200                 205             
          Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                          245                 250                 255     
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                      260                 265                 270         
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                  275                 280                 285             
          Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
              290                 295                 300                 
          Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
          305                 310                 315                 320 
          Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                          325                 330                 335     
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                      340                 345                 350         
          Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                  355                 360                 365             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly 
              370                 375                 380                 
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val 
          385                 390                 395                 400 
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                          405                 410                 415     
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
                      420                 425                 430         
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                  435                 440                 445             
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
              450                 455                 460                 
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
          465                 470                 475                 480 
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                          485                 490                 495     
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  515                 520                 525             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              530                 535                 540                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          545                 550                 555                 560 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          565                 570                 575     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      580                 585                 590         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  595                 600                 605             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              610                 615                 620                 
          Leu Val Thr Val Ser Ser His His His His His His 
          625                 630                 635     
          <![CDATA[<210>  179]]>
          <![CDATA[<211>  636]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  ]]>人工序列
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro450 雙重靶半格式3]]>
          <![CDATA[<400>  179]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Val 
                  115                 120                 125             
          Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Thr Leu Ser 
              130                 135                 140                 
          Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe 
          145                 150                 155                 160 
          Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile Ser Trp 
                          165                 170                 175     
          Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser 
                  195                 200                 205             
          Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Ala Ala Gly 
              210                 215                 220                 
          Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                          245                 250                 255     
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                      260                 265                 270         
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
                  275                 280                 285             
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
              290                 295                 300                 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
          305                 310                 315                 320 
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                          325                 330                 335     
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                      340                 345                 350         
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly 
                  355                 360                 365             
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          405                 410                 415     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      420                 425                 430         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  435                 440                 445             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  515                 520                 525             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              530                 535                 540                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          545                 550                 555                 560 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          565                 570                 575     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      580                 585                 590         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  595                 600                 605             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              610                 615                 620                 
          Leu Val Thr Val Ser Ser His His His His His His 
          625                 630                 635     
          <![CDATA[<210>  180]]>
          <![CDATA[<211>  636]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro451 雙重靶半格式3]]>
          <![CDATA[<400>  180]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  115                 120                 125             
          Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              130                 135                 140                 
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          145                 150                 155                 160 
          Thr Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn 
                          165                 170                 175     
          Glu Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr 
                      180                 185                 190         
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                  195                 200                 205             
          Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                          245                 250                 255     
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                      260                 265                 270         
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
                  275                 280                 285             
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
              290                 295                 300                 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
          305                 310                 315                 320 
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                          325                 330                 335     
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                      340                 345                 350         
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly 
                  355                 360                 365             
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          405                 410                 415     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      420                 425                 430         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  435                 440                 445             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          465                 470                 475                 480 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  515                 520                 525             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              530                 535                 540                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          545                 550                 555                 560 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          565                 570                 575     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      580                 585                 590         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  595                 600                 605             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              610                 615                 620                 
          Leu Val Thr Val Ser Ser His His His His His His 
          625                 630                 635     
          <![CDATA[<210>  181]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro479- 異源性 - 格式2]]>
          <![CDATA[<400>  181]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr Ser Met 
                          405                 410                 415     
          Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val Ala Ala 
                      420                 425                 430         
          Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
          625                 630                 635                 640 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
                          645                 650                 655     
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                      660                 665                 670         
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                  675                 680                 685             
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  182]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro480- 異源性 - 格式2]]>
          <![CDATA[<400>  182]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr His Met Gly Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Asn 
                      420                 425                 430         
          Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Gly 
          465                 470                 475                 480 
          Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
          625                 630                 635                 640 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
                          645                 650                 655     
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                      660                 665                 670         
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                  675                 680                 685             
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  183]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro495 - 格式2]]>
          <![CDATA[<400>  183]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr His Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
                      420                 425                 430         
          Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Asp 
                          565                 570                 575     
          Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
          625                 630                 635                 640 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                          645                 650                 655     
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys His Ala Met 
                      660                 665                 670         
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                  675                 680                 685             
          Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Ala Tyr Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  184]]>
          <![CDATA[<211>  15]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成可裂解連接子 - MMP9-2]]>
          <![CDATA[<400>  184]]>
          Ser Gly Gly Pro Gly Pro Ala Gly Leu Lys Gly Ala Pro Gly Ser 
          1               5                   10                  15  
          <![CDATA[<210>  185]]>
          <![CDATA[<211>  887]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro141]]>
          <![CDATA[<400>  185]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Pro Ala Gly Met Lys Gly Leu Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn 
                          565                 570                 575     
          Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
          625                 630                 635                 640 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                          645                 650                 655     
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Ser Ala Met 
                      660                 665                 670         
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                  675                 680                 685             
          Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Ala Tyr Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Thr Phe Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser 
                          885         
          <![CDATA[<210>  186]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro160]]>
          <![CDATA[<400>  186]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Pro Ala Gly Met Lys Gly Leu Gly Gln Thr Val Val Thr 
                      260                 265                 270         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  275                 280                 285             
          Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              290                 295                 300                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
          305                 310                 315                 320 
          Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                          325                 330                 335     
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                      340                 345                 350         
          Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
                  355                 360                 365             
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          385                 390                 395                 400 
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                          405                 410                 415     
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                      420                 425                 430         
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
          465                 470                 475                 480 
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                          485                 490                 495     
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro 
                      500                 505                 510         
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
                          565                 570                 575     
          Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                          645                 650                 655     
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
                      660                 665                 670         
          Ser Gly Phe Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala 
                  675                 680                 685             
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
              690                 695                 700                 
          Asn Tyr Ala Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly 
              770                 775                 780                 
          Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  187]]>
          <![CDATA[<211>  899]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro161]]>
          <![CDATA[<400>  187]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Pro Ala Gly Met Lys Gly Leu Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys His 
                          565                 570                 575     
          Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                      580                 585                 590         
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                  595                 600                 605             
          Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr Lys 
              610                 615                 620                 
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                          645                 650                 655     
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                      660                 665                 670         
          Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                  675                 680                 685             
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
              690                 695                 700                 
          Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
          705                 710                 715                 720 
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
                          725                 730                 735     
          Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
                      740                 745                 750         
          Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                  755                 760                 765             
          Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser 
              770                 775                 780                 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
          785                 790                 795                 800 
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
                          805                 810                 815     
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                      820                 825                 830         
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
                  835                 840                 845             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
              850                 855                 860                 
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
          865                 870                 875                 880 
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
                          885                 890                 895     
          Val Ser Ser 
          <![CDATA[<210>  188]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro162]]>
          <![CDATA[<400>  188]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Val Tyr Ala Asp Ser Leu Glu Asp Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Val Tyr Ala Asp 
                      500                 505                 510         
          Ser Leu Glu Asp Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys 
                          565                 570                 575     
          His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
              690                 695                 700                 
          Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Ser Val Tyr Ala Asp Ser Leu Glu Asp Gly Gly 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  189]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro189]]>
          <![CDATA[<400>  189]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Ala Arg Leu Gln Ser Ala Ala Pro Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ala Arg Leu Gln 
                      500                 505                 510         
          Ser Ala Ala Pro Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys 
                          565                 570                 575     
          His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
              690                 695                 700                 
          Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Ser Ala Arg Leu Gln Ser Ala Ala Pro Gly Gly 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  190]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro164]]>
          <![CDATA[<400>  190]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Lys Lys Leu Ala Asp Glu Pro Glu Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala 
                      500                 505                 510         
          Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys 
                          565                 570                 575     
          His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
              690                 695                 700                 
          Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  191]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro 191]]>
          <![CDATA[<400>  191]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Leu Ser Gly Arg Ser Asp Asn His Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Leu Ser Gly Arg 
                      500                 505                 510         
          Ser Asp Asn His Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys 
                          565                 570                 575     
          His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
              690                 695                 700                 
          Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  192]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro166]]>
          <![CDATA[<400>  192]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
                          245                 250                 255     
          Phe Thr Arg Gln Ala Arg Val Val Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Phe Thr Arg Gln 
                      500                 505                 510         
          Ala Arg Val Val Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Lys 
                          565                 570                 575     
          His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Gly Ser Arg Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Ser Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
              690                 695                 700                 
          Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Thr Phe Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Ser Phe Thr Arg Gln Ala Arg Val Val Gly Gly 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  193]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro169]]>
          <![CDATA[<400>  193]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Pro Ala Gly Met Lys Gly Leu Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly His Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
              690                 695                 700                 
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                      740                 745                 750         
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                  755                 760                 765             
          Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro 
              770                 775                 780                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          785                 790                 795                 800 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                          805                 810                 815     
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      820                 825                 830         
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                  835                 840                 845             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
              850                 855                 860                 
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
          865                 870                 875                 880 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
                          885                 890                 895     
          Val Thr Val Ser Ser 
                      900     
          <![CDATA[<210>  194]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro170]]>
          <![CDATA[<400>  194]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Val Tyr Ala Asp Ser Leu Glu Asp Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Val Tyr Ala Asp 
                      500                 505                 510         
          Ser Leu Glu Asp Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Ser Val Tyr Ala Asp Ser Leu Glu Asp 
              770                 775                 780                 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  195]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro171]]>
          <![CDATA[<400>  195]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Ala Arg Leu Gln Ser Ala Ala Pro Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ala Arg Leu Gln 
                      500                 505                 510         
          Ser Ala Ala Pro Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Ser Ala Arg Leu Gln Ser Ala Ala Pro 
              770                 775                 780                 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  196]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro172]]>
          <![CDATA[<400>  196]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Lys Lys Leu Ala Asp Glu Pro Glu Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala 
                      500                 505                 510         
          Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu 
              770                 775                 780                 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  197]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro173]]>
          <![CDATA[<400>  197]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Leu Ser Gly Arg Ser Asp Asn His Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Leu Ser Gly Arg 
                      500                 505                 510         
          Ser Asp Asn His Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His 
              770                 775                 780                 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  198]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro174]]>
          <![CDATA[<400>  198]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
                          245                 250                 255     
          Phe Thr Arg Gln Ala Arg Val Val Gly Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn 
                          405                 410                 415     
          Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                      420                 425                 430         
          Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
          465                 470                 475                 480 
          Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Phe Thr Arg Gln 
                      500                 505                 510         
          Ala Arg Val Val Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                  515                 520                 525             
          Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
              530                 535                 540                 
          Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
          545                 550                 555                 560 
          Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Ser Phe Thr Arg Gln Ala Arg Val Val 
              770                 775                 780                 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  199]]>
          <![CDATA[<211>  888]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro176]]>
          <![CDATA[<400>  199]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Pro Ala Gly Met Lys Gly Leu Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Asp 
                          565                 570                 575     
          Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
          625                 630                 635                 640 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                          645                 650                 655     
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 
                      660                 665                 670         
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                  675                 680                 685             
          Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser 
              690                 695                 700                 
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
          705                 710                 715                 720 
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                          725                 730                 735     
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala 
                      740                 745                 750         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  755                 760                 765             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              770                 775                 780                 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          785                 790                 795                 800 
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                          805                 810                 815     
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                      820                 825                 830         
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                  835                 840                 845             
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
              850                 855                 860                 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
          865                 870                 875                 880 
          Gly Thr Leu Val Thr Val Ser Ser 
                          885             
          <![CDATA[<210>  200]]>
          <![CDATA[<211>  892]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro178]]>
          <![CDATA[<400>  200]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Lys Lys Leu Ala Asp Glu Pro Glu Gly Gln Thr Val Val Thr 
                      260                 265                 270         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  275                 280                 285             
          Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              290                 295                 300                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
          305                 310                 315                 320 
          Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                          325                 330                 335     
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                      340                 345                 350         
          Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
                  355                 360                 365             
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          385                 390                 395                 400 
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                          405                 410                 415     
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                      420                 425                 430         
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
          465                 470                 475                 480 
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                          485                 490                 495     
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                      500                 505                 510         
          Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val 
                  515                 520                 525             
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
              530                 535                 540                 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          545                 550                 555                 560 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                          565                 570                 575     
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                      580                 585                 590         
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                  595                 600                 605             
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
              610                 615                 620                 
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                          645                 650                 655     
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                      660                 665                 670         
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                  675                 680                 685             
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
              690                 695                 700                 
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
          705                 710                 715                 720 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                          725                 730                 735     
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                      740                 745                 750         
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760                 765             
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              770                 775                 780                 
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
          785                 790                 795                 800 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
                          805                 810                 815     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                      820                 825                 830         
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                  835                 840                 845             
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
              850                 855                 860                 
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
          865                 870                 875                 880 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890         
          <![CDATA[<210>  201]]>
          <![CDATA[<211>  894]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro179]]>
          <![CDATA[<400>  201]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Ser Gln Thr Val 
                      260                 265                 270         
          Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                  275                 280                 285             
          Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
              290                 295                 300                 
          Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
          305                 310                 315                 320 
          Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                          325                 330                 335     
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                      340                 345                 350         
          Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val 
                  355                 360                 365             
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
              370                 375                 380                 
          Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
          385                 390                 395                 400 
          Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
                          405                 410                 415     
          Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                      420                 425                 430         
          Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
                  435                 440                 445             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
              450                 455                 460                 
          Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
          465                 470                 475                 480 
          Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
                          485                 490                 495     
          Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                      500                 505                 510         
          Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr 
                  515                 520                 525             
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
              530                 535                 540                 
          Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
          545                 550                 555                 560 
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
                          565                 570                 575     
          Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser 
                      580                 585                 590         
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                  595                 600                 605             
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 
              610                 615                 620                 
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
          625                 630                 635                 640 
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                          645                 650                 655     
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                      660                 665                 670         
          Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                  675                 680                 685             
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp 
              690                 695                 700                 
          Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
          705                 710                 715                 720 
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
                          725                 730                 735     
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
                      740                 745                 750         
          Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                  755                 760                 765             
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
              770                 775                 780                 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
          785                 790                 795                 800 
          Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val 
                          805                 810                 815     
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                      820                 825                 830         
          Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr 
                  835                 840                 845             
          Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
              850                 855                 860                 
          Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
          865                 870                 875                 880 
          Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 
          <![CDATA[<210>  202]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro180]]>
          <![CDATA[<400>  202]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Ser Gln 
                      260                 265                 270         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  275                 280                 285             
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              290                 295                 300                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          305                 310                 315                 320 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
                          325                 330                 335     
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                      340                 345                 350         
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                  355                 360                 365             
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val 
          385                 390                 395                 400 
          Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr 
                          405                 410                 415     
          Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                      420                 425                 430         
          Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr 
                  435                 440                 445             
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              450                 455                 460                 
          Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
          465                 470                 475                 480 
          Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu 
                          485                 490                 495     
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                      500                 505                 510         
          Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser 
                  515                 520                 525             
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
              530                 535                 540                 
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
          545                 550                 555                 560 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                          565                 570                 575     
          Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg 
                      580                 585                 590         
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                  595                 600                 605             
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
              610                 615                 620                 
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              770                 775                 780                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
          785                 790                 795                 800 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
                          805                 810                 815     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                      820                 825                 830         
          Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg 
                  835                 840                 845             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
              850                 855                 860                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
          865                 870                 875                 880 
          Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 895     
          <![CDATA[<210>  203]]>
          <![CDATA[<211>  898]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro181]]>
          <![CDATA[<400>  203]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Gly 
                      260                 265                 270         
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                  275                 280                 285             
          Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser 
              290                 295                 300                 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
          305                 310                 315                 320 
          Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg 
                          325                 330                 335     
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                      340                 345                 350         
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser 
                  355                 360                 365             
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
              370                 375                 380                 
          Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
          385                 390                 395                 400 
          Ser Val Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly 
                          405                 410                 415     
          Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly 
                      420                 425                 430         
          Lys Glu Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr 
                  435                 440                 445             
          Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
              450                 455                 460                 
          Ala Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
          465                 470                 475                 480 
          Thr Ala Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly 
                          485                 490                 495     
          Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                      500                 505                 510         
          Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly 
                  515                 520                 525             
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
              530                 535                 540                 
          Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr 
          545                 550                 555                 560 
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
                          565                 570                 575     
          Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro 
                      580                 585                 590         
          Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                  595                 600                 605             
          Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
              610                 615                 620                 
          Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
          625                 630                 635                 640 
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                          645                 650                 655     
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
                      660                 665                 670         
          Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
                  675                 680                 685             
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp 
              690                 695                 700                 
          Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr 
          705                 710                 715                 720 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          725                 730                 735     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      740                 745                 750         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  755                 760                 765             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
              770                 775                 780                 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
          785                 790                 795                 800 
          Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly 
                          805                 810                 815     
          Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                      820                 825                 830         
          Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys 
                  835                 840                 845             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
              850                 855                 860                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
          865                 870                 875                 880 
          Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val 
                          885                 890                 895     
          Ser Ser 
          <![CDATA[<210>  204]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro182]]>
          <![CDATA[<400>  204]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Pro Ala Gly Met Lys Gly Leu Gly Gln Thr Val Val Thr 
                      260                 265                 270         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  275                 280                 285             
          Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              290                 295                 300                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
          305                 310                 315                 320 
          Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                          325                 330                 335     
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                      340                 345                 350         
          Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
                  355                 360                 365             
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          385                 390                 395                 400 
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                          405                 410                 415     
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                      420                 425                 430         
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
          465                 470                 475                 480 
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                          485                 490                 495     
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro 
                      500                 505                 510         
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
                          565                 570                 575     
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                      580                 585                 590         
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                  595                 600                 605             
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
              610                 615                 620                 
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                          645                 650                 655     
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                      660                 665                 670         
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                  675                 680                 685             
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
              690                 695                 700                 
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
          705                 710                 715                 720 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                          725                 730                 735     
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                      740                 745                 750         
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  755                 760                 765             
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
              770                 775                 780                 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
          785                 790                 795                 800 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                          805                 810                 815     
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                      820                 825                 830         
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                  835                 840                 845             
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
              850                 855                 860                 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
          865                 870                 875                 880 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890     
          <![CDATA[<210>  205]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro183]]>
          <![CDATA[<400>  205]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Ser Gly Pro Ala Gly Met Lys Gly Leu Gly Ser Gln Thr Val 
                      260                 265                 270         
          Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                  275                 280                 285             
          Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
              290                 295                 300                 
          Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
          305                 310                 315                 320 
          Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                          325                 330                 335     
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                      340                 345                 350         
          Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val 
                  355                 360                 365             
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
              370                 375                 380                 
          Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
          385                 390                 395                 400 
          Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
                          405                 410                 415     
          Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                      420                 425                 430         
          Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
                  435                 440                 445             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
              450                 455                 460                 
          Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
          465                 470                 475                 480 
          Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
                          485                 490                 495     
          Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly 
                      500                 505                 510         
          Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val 
                  515                 520                 525             
          Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
              530                 535                 540                 
          Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
          545                 550                 555                 560 
          Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                          565                 570                 575     
          Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly 
                      580                 585                 590         
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                  595                 600                 605             
          Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp 
              610                 615                 620                 
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
          625                 630                 635                 640 
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                          645                 650                 655     
          Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                      660                 665                 670         
          Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                  675                 680                 685             
          Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp 
              690                 695                 700                 
          Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
          705                 710                 715                 720 
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
                          725                 730                 735     
          Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
                      740                 745                 750         
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                  755                 760                 765             
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
              770                 775                 780                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
          785                 790                 795                 800 
          Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
                          805                 810                 815     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                      820                 825                 830         
          Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                  835                 840                 845             
          Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
              850                 855                 860                 
          Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
          865                 870                 875                 880 
          Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890             
          <![CDATA[<210>  206]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro184]]>
          <![CDATA[<400>  206]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Ser Gly Pro Ala Gly Met Lys Gly Leu Gly Gly Ser Gln 
                      260                 265                 270         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  275                 280                 285             
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              290                 295                 300                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          305                 310                 315                 320 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
                          325                 330                 335     
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                      340                 345                 350         
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                  355                 360                 365             
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
              370                 375                 380                 
          Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val 
          385                 390                 395                 400 
          Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr 
                          405                 410                 415     
          Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                      420                 425                 430         
          Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr 
                  435                 440                 445             
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              450                 455                 460                 
          Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
          465                 470                 475                 480 
          Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu 
                          485                 490                 495     
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                      500                 505                 510         
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                  515                 520                 525             
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
              530                 535                 540                 
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
          545                 550                 555                 560 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
                          565                 570                 575     
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                      580                 585                 590         
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                  595                 600                 605             
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
              610                 615                 620                 
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
              690                 695                 700                 
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                      740                 745                 750         
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                  755                 760                 765             
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              770                 775                 780                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
          785                 790                 795                 800 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
                          805                 810                 815     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                      820                 825                 830         
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                  835                 840                 845             
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
              850                 855                 860                 
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
          865                 870                 875                 880 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 895 
          <![CDATA[<210>  207]]>
          <![CDATA[<211>  897]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro185]]>
          <![CDATA[<400>  207]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Pro Ala Gly Met Lys Gly Leu Gly Gly Gly 
                      260                 265                 270         
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                  275                 280                 285             
          Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser 
              290                 295                 300                 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
          305                 310                 315                 320 
          Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg 
                          325                 330                 335     
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                      340                 345                 350         
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser 
                  355                 360                 365             
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
              370                 375                 380                 
          Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly 
          385                 390                 395                 400 
          Ser Val Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly 
                          405                 410                 415     
          Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly 
                      420                 425                 430         
          Lys Glu Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr 
                  435                 440                 445             
          Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
              450                 455                 460                 
          Ala Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
          465                 470                 475                 480 
          Thr Ala Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly 
                          485                 490                 495     
          Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
                      500                 505                 510         
          Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly 
                  515                 520                 525             
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
              530                 535                 540                 
          Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
          545                 550                 555                 560 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
                          565                 570                 575     
          Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala 
                      580                 585                 590         
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                  595                 600                 605             
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr 
              610                 615                 620                 
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
          625                 630                 635                 640 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                          645                 650                 655     
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                      660                 665                 670         
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                  675                 680                 685             
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
              690                 695                 700                 
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              770                 775                 780                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
          785                 790                 795                 800 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met 
                          805                 810                 815     
          Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                      820                 825                 830         
          Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly 
                  835                 840                 845             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
              850                 855                 860                 
          Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
          865                 870                 875                 880 
          Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                          885                 890                 895     
          Ser 
          <![CDATA[<210>  208]]>
          <![CDATA[<211>]]>  889
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro188]]>
          <![CDATA[<400>  208]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Pro Ala Gly Met Lys Gly Leu Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 
          <![CDATA[<210>  209]]>
          <![CDATA[<211>  897]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro189]]>
          <![CDATA[<400>  209]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 
          625                 630                 635                 640 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                          645                 650                 655     
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                      660                 665                 670         
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                  675                 680                 685             
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
              690                 695                 700                 
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              770                 775                 780                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
          785                 790                 795                 800 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met 
                          805                 810                 815     
          Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                      820                 825                 830         
          Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly 
                  835                 840                 845             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
              850                 855                 860                 
          Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
          865                 870                 875                 880 
          Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                          885                 890                 895     
          Ser 
          <![CDATA[<210>  210]]>
          <![CDATA[<211>  898]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro190]]>
          <![CDATA[<400>  210]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                          645                 650                 655     
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
                      660                 665                 670         
          Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
                  675                 680                 685             
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp 
              690                 695                 700                 
          Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr 
          705                 710                 715                 720 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          725                 730                 735     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      740                 745                 750         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  755                 760                 765             
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
              770                 775                 780                 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
          785                 790                 795                 800 
          Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly 
                          805                 810                 815     
          Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                      820                 825                 830         
          Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys 
                  835                 840                 845             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
              850                 855                 860                 
          Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
          865                 870                 875                 880 
          Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val 
                          885                 890                 895     
          Ser Ser 
          <![CDATA[<210>  211]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro191]]>
          <![CDATA[<400>  211]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 
          625                 630                 635                 640 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                          645                 650                 655     
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                      660                 665                 670         
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                  675                 680                 685             
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
              690                 695                 700                 
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly 
              770                 775                 780                 
          Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
          785                 790                 795                 800 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                          805                 810                 815     
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                      820                 825                 830         
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                  835                 840                 845             
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
              850                 855                 860                 
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
          865                 870                 875                 880 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
                          885                 890                 895     
          Thr Leu Val Thr Val Ser Ser 
                      900             
          <![CDATA[<210>  212]]>
          <![CDATA[<211>  905]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro192]]>
          <![CDATA[<400>  212]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                          645                 650                 655     
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
                      660                 665                 670         
          Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
                  675                 680                 685             
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp 
              690                 695                 700                 
          Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr 
          705                 710                 715                 720 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          725                 730                 735     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
                      740                 745                 750         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  755                 760                 765             
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu 
              770                 775                 780                 
          Pro Glu Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
          785                 790                 795                 800 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                          805                 810                 815     
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                      820                 825                 830         
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                  835                 840                 845             
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
              850                 855                 860                 
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
          865                 870                 875                 880 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
                          885                 890                 895     
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                      900                 905 
          <![CDATA[<210>  213]]>
          <![CDATA[<211>  763]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro193]]>
          <![CDATA[<400>  213]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
              370                 375                 380                 
          Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          385                 390                 395                 400 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                          405                 410                 415     
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
                  435                 440                 445             
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
              450                 455                 460                 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
          465                 470                 475                 480 
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                          485                 490                 495     
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                      500                 505                 510         
          Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
                          565                 570                 575     
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                      580                 585                 590         
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                  595                 600                 605             
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
              610                 615                 620                 
          Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Pro Gly Pro Ala 
          625                 630                 635                 640 
          Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                          645                 650                 655     
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
                      660                 665                 670         
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                  675                 680                 685             
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
              690                 695                 700                 
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
                      740                 745                 750         
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760             
          <![CDATA[<210>  214]]>
          <![CDATA[<211>  892]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro195]]>
          <![CDATA[<400>  214]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                      20                  25                  30          
          Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                      100                 105                 110         
          Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              130                 135                 140                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
          145                 150                 155                 160 
          Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro 
                          165                 170                 175     
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                      180                 185                 190         
          Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser 
                  195                 200                 205             
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
              210                 215                 220                 
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly 
          225                 230                 235                 240 
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                          245                 250                 255     
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      260                 265                 270         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  275                 280                 285             
          Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              290                 295                 300                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          305                 310                 315                 320 
          Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          325                 330                 335     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      340                 345                 350         
          Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  355                 360                 365             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              370                 375                 380                 
          Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly 
          385                 390                 395                 400 
          Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser 
                          405                 410                 415     
          Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                      420                 425                 430         
          Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser 
                  435                 440                 445             
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
              450                 455                 460                 
          Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
          465                 470                 475                 480 
          Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr 
                          485                 490                 495     
          Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly 
                      500                 505                 510         
          Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val 
                  515                 520                 525             
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
              530                 535                 540                 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          545                 550                 555                 560 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                          565                 570                 575     
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                      580                 585                 590         
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                  595                 600                 605             
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
              610                 615                 620                 
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                          645                 650                 655     
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                      660                 665                 670         
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                  675                 680                 685             
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
              690                 695                 700                 
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
          705                 710                 715                 720 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                          725                 730                 735     
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                      740                 745                 750         
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760                 765             
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              770                 775                 780                 
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
          785                 790                 795                 800 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
                          805                 810                 815     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                      820                 825                 830         
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                  835                 840                 845             
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
              850                 855                 860                 
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
          865                 870                 875                 880 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890         
          <![CDATA[<210>  215]]>
          <![CDATA[<211>  889]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro196]]>
          <![CDATA[<400>  215]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
              130                 135                 140                 
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala 
          145                 150                 155                 160 
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
                          165                 170                 175     
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr 
                      180                 185                 190         
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                  195                 200                 205             
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu 
              210                 215                 220                 
          Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
          225                 230                 235                 240 
          Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 
          <![CDATA[<210>  216]]>
          <![CDATA[<211>  888]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro197]]>
          <![CDATA[<400>  216]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser 
                  515                 520                 525             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              530                 535                 540                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
          545                 550                 555                 560 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          565                 570                 575     
          Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe 
                      580                 585                 590         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  595                 600                 605             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
              610                 615                 620                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          625                 630                 635                 640 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          645                 650                 655     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      660                 665                 670         
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  675                 680                 685             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              690                 695                 700                 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
          705                 710                 715                 720 
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                          725                 730                 735     
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                      740                 745                 750         
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
                  755                 760                 765             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              770                 775                 780                 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          785                 790                 795                 800 
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                          805                 810                 815     
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                      820                 825                 830         
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                  835                 840                 845             
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
              850                 855                 860                 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
          865                 870                 875                 880 
          Gly Thr Leu Val Thr Val Ser Ser 
                          885             
          <![CDATA[<210>  217]]>
          <![CDATA[<211>  888]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro198]]>
          <![CDATA[<400>  217]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
              130                 135                 140                 
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala 
          145                 150                 155                 160 
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
                          165                 170                 175     
          Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr 
                      180                 185                 190         
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                  195                 200                 205             
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu 
              210                 215                 220                 
          Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
          225                 230                 235                 240 
          Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                          245                 250                 255     
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                      260                 265                 270         
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
                  275                 280                 285             
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
              290                 295                 300                 
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
          305                 310                 315                 320 
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                          325                 330                 335     
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
                      340                 345                 350         
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
                  355                 360                 365             
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Glu Val Gln Leu Val Glu Ser 
                  515                 520                 525             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              530                 535                 540                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
          545                 550                 555                 560 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          565                 570                 575     
          Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe 
                      580                 585                 590         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  595                 600                 605             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
              610                 615                 620                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          625                 630                 635                 640 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          645                 650                 655     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      660                 665                 670         
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  675                 680                 685             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              690                 695                 700                 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
          705                 710                 715                 720 
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                          725                 730                 735     
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                      740                 745                 750         
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
                  755                 760                 765             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              770                 775                 780                 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          785                 790                 795                 800 
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                          805                 810                 815     
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                      820                 825                 830         
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                  835                 840                 845             
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
              850                 855                 860                 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
          865                 870                 875                 880 
          Gly Thr Leu Val Thr Val Ser Ser 
                          885             
          <![CDATA[<210>  218]]>
          <![CDATA[<211>  885]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro199]]>
          <![CDATA[<400>  218]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Thr Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn Leu Met 
                          405                 410                 415     
          Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Arg 
                      420                 425                 430         
          Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Leu 
          465                 470                 475                 480 
          Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln Gly Thr 
                          485                 490                 495     
          Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys 
                      500                 505                 510         
          Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                  515                 520                 525             
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
              530                 535                 540                 
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
          545                 550                 555                 560 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
                          565                 570                 575     
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                      580                 585                 590         
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                  595                 600                 605             
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
              610                 615                 620                 
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
          625                 630                 635                 640 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                          645                 650                 655     
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                      660                 665                 670         
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                  675                 680                 685             
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
              690                 695                 700                 
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
          705                 710                 715                 720 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                          725                 730                 735     
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                      740                 745                 750         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  755                 760                 765             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              770                 775                 780                 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
          785                 790                 795                 800 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          805                 810                 815     
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                      820                 825                 830         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                  835                 840                 845             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
              850                 855                 860                 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
          865                 870                 875                 880 
          Val Thr Val Ser Ser 
                          885 
          <![CDATA[<210>  219]]>
          <![CDATA[<211>  886]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro200]]>
          <![CDATA[<400>  219]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser 
                      20                  25                  30          
          Ile Asn Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
                  35                  40                  45              
          Leu Val Ala Arg Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser 
              50                  55                  60                  
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
          65                  70                  75                  80  
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                          85                  90                  95      
          Cys Asn Leu Leu Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Thr Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Thr Gly Ser Ile Phe Ser Ile Asn Leu Met 
                          405                 410                 415     
          Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Arg 
                      420                 425                 430         
          Ile Thr Ser Gly Asp Ser Thr Val Tyr Ala Asp Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Leu Leu 
          465                 470                 475                 480 
          Leu Arg Ser Ser Pro Gly Ala Thr Thr Pro Tyr Trp Gly Gln Gly Thr 
                          485                 490                 495     
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys Leu Ala Asp Glu 
                      500                 505                 510         
          Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                  515                 520                 525             
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
              530                 535                 540                 
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
          545                 550                 555                 560 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp 
                          565                 570                 575     
          Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                      580                 585                 590         
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                  595                 600                 605             
          Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
              610                 615                 620                 
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
          625                 630                 635                 640 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
                          645                 650                 655     
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                      660                 665                 670         
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                  675                 680                 685             
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
              690                 695                 700                 
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
          705                 710                 715                 720 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                          725                 730                 735     
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                      740                 745                 750         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                  755                 760                 765             
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              770                 775                 780                 
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
          785                 790                 795                 800 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                          805                 810                 815     
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                      820                 825                 830         
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                  835                 840                 845             
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
              850                 855                 860                 
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
          865                 870                 875                 880 
          Leu Val Thr Val Ser Ser 
                          885     
          <![CDATA[<210>  220]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro189 (具有非活化aCD3結構域之間之長連接子的Pro186)]]>
          <![CDATA[<400>  220]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 
          625                 630                 635                 640 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                          645                 650                 655     
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                      660                 665                 670         
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                  675                 680                 685             
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
              690                 695                 700                 
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              770                 775                 780                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
          785                 790                 795                 800 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met 
                          805                 810                 815     
          Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                      820                 825                 830         
          Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly 
                  835                 840                 845             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
              850                 855                 860                 
          Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
          865                 870                 875                 880 
          Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                          885                 890                 895     
          Ser His His His His His His 
                      900             
          <![CDATA[<210>  221]]>
          <![CDATA[<211>  636]]>
          <![CDATA[<212]]>>  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成構築體 - Pro206 (Pro186 活性結構域 + aHSA)]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  221]]&gt;
          <br/>
          <br/><![CDATA[Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  515                 520                 525             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              530                 535                 540                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          545                 550                 555                 560 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          565                 570                 575     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      580                 585                 590         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  595                 600                 605             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              610                 615                 620                 
          Leu Val Thr Val Ser Ser His His His His His His 
          625                 630                 635     
          <![CDATA[<210>  222]]>
          <![CDATA[<211>  513]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro227 (Pro22 aB7H3 hF7)]]>
          <![CDATA[<400>  222]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  115                 120                 125             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              130                 135                 140                 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
          145                 150                 155                 160 
          Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys 
                          165                 170                 175     
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
                      180                 185                 190         
          Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                  195                 200                 205             
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
              210                 215                 220                 
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser 
          225                 230                 235                 240 
          Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                          245                 250                 255     
          Ser Ser Gly Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly 
                      260                 265                 270         
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                  275                 280                 285             
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
              290                 295                 300                 
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
          305                 310                 315                 320 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
                          325                 330                 335     
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                      340                 345                 350         
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                  355                 360                 365             
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
              370                 375                 380                 
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
          385                 390                 395                 400 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
                          405                 410                 415     
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                      420                 425                 430         
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                  435                 440                 445             
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
              450                 455                 460                 
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
          465                 470                 475                 480 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
                          485                 490                 495     
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
                      500                 505                 510         
          His 
          <![CDATA[<210>  223]]>
          <![CDATA[<211>  511]]>
          <![CDATA[<212>]]>  PRT
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro228 (Pro22 aB7H3 hF12)]]>
          <![CDATA[<400>  223]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              130                 135                 140                 
          Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
          145                 150                 155                 160 
          Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                          165                 170                 175     
          Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                      180                 185                 190         
          Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                  195                 200                 205             
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
              210                 215                 220                 
          Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile 
          225                 230                 235                 240 
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          245                 250                 255     
          Gly Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Ser 
                      260                 265                 270         
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                  275                 280                 285             
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
              290                 295                 300                 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
          305                 310                 315                 320 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
                          325                 330                 335     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      340                 345                 350         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                  355                 360                 365             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              370                 375                 380                 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
          385                 390                 395                 400 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                          405                 410                 415     
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                      420                 425                 430         
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                  435                 440                 445             
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
              450                 455                 460                 
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
          465                 470                 475                 480 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
                          485                 490                 495     
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                      500                 505                 510     
          <![CDATA[<210>  224]]>
          <![CDATA[<211>  512]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro244 (Pro51 aB7H3 hF7)]]>
          <![CDATA[<400>  224]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  115                 120                 125             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              130                 135                 140                 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
          145                 150                 155                 160 
          Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys 
                          165                 170                 175     
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
                      180                 185                 190         
          Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                  195                 200                 205             
          Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
              210                 215                 220                 
          Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser 
          225                 230                 235                 240 
          Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                          245                 250                 255     
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                      260                 265                 270         
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
                  275                 280                 285             
          Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser 
              290                 295                 300                 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
          305                 310                 315                 320 
          Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg 
                          325                 330                 335     
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                      340                 345                 350         
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser 
                  355                 360                 365             
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
              370                 375                 380                 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
          385                 390                 395                 400 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                          405                 410                 415     
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                      420                 425                 430         
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                  435                 440                 445             
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
              450                 455                 460                 
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
          465                 470                 475                 480 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
                          485                 490                 495     
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                      500                 505                 510         
          <![CDATA[<210>  225]]>
          <![CDATA[<211>  510]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro245 (Pro51 aB7H3 hF12)]]>
          <![CDATA[<400>  225]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              130                 135                 140                 
          Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
          145                 150                 155                 160 
          Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                          165                 170                 175     
          Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 
                      180                 185                 190         
          Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                  195                 200                 205             
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
              210                 215                 220                 
          Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile 
          225                 230                 235                 240 
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          245                 250                 255     
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                      260                 265                 270         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  275                 280                 285             
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              290                 295                 300                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          305                 310                 315                 320 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
                          325                 330                 335     
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                      340                 345                 350         
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                  355                 360                 365             
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
              370                 375                 380                 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          385                 390                 395                 400 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                          405                 410                 415     
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                  435                 440                 445             
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
          465                 470                 475                 480 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
                          485                 490                 495     
          Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                      500                 505                 510 
          <![CDATA[<210>  226]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro247 (具有穿]]>膜肽酶連接子之人類化Pro186)
          <![CDATA[<400>  226]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  227]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212]]>>  PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt;  人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt;]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt;  合成構築體 - Pro248 (具有CathS 連接子之人類化Pro186)]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt;  227]]&gt;
          <br/>
          <br/><![CDATA[Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ala Arg 
                      500                 505                 510         
          Leu Gln Ser Ala Ala Pro Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  228]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro249 (具有穿膜肽酶/粒酶B連接子之人類化Pro186]]>)
          <![CDATA[<400>  228]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Val Tyr 
                      500                 505                 510         
          Ala Asp Ser Leu Glu Asp Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  ]]>229
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro250 (具有S9 - CathS/MMP9 連接子之人類化Pro186)]]>
          <![CDATA[<400>  229]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Arg Leu Gln Ser 
                      500                 505                 510         
          Ala Ala Pro Ala Gly Leu Lys Gly Ala Gly Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  230]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro251 (具有ST14(MS)連接子之人類化Pro186)]]>
          <![CDATA[<400>  230]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Leu Ser 
                      500                 505                 510         
          Gly Arg Ser Asp Asn His Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  231]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro252 (具有ST14(MS)連接子之人類化Pro186)]]>
          <![CDATA[<400>  231]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Phe Thr 
                      500                 505                 510         
          Arg Gln Ala Arg Val Val Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895     
          <![CDATA[<210>  232]]>
          <![CDATA[<211>  897]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro253 (具有MMP9v 連接子之人類化Pro186)]]>
          <![CDATA[<400>  232]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Gly Pro Gly 
                      500                 505                 510         
          Pro Ala Gly Met His Gly Leu Pro Gly Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
                          565                 570                 575     
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                      580                 585                 590         
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                  595                 600                 605             
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
              610                 615                 620                 
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                          645                 650                 655     
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                      660                 665                 670         
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                  675                 680                 685             
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
              690                 695                 700                 
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
          705                 710                 715                 720 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                          725                 730                 735     
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                      740                 745                 750         
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  755                 760                 765             
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
              770                 775                 780                 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
          785                 790                 795                 800 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                          805                 810                 815     
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                      820                 825                 830         
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                  835                 840                 845             
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
              850                 855                 860                 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
          865                 870                 875                 880 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
                          885                 890                 895     
          His 
          <![CDATA[<210>  233]]>
          <![CDATA[<211>  902]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro261 (具有長活性結構域aCD3 連接子之人類化Pro186)]]>
          <![CDATA[<400>  233]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      260                 265                 270         
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                  275                 280                 285             
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
              290                 295                 300                 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
          305                 310                 315                 320 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
                          325                 330                 335     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      340                 345                 350         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                  355                 360                 365             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              370                 375                 380                 
          Ser Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val 
          385                 390                 395                 400 
          Val Arg Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg 
                          405                 410                 415     
          Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Glu Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly 
                  435                 440                 445             
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
          465                 470                 475                 480 
          Ala Leu Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr 
                          485                 490                 495     
          Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      500                 505                 510         
          Ser Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser 
                  515                 520                 525             
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
              530                 535                 540                 
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
          545                 550                 555                 560 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                          565                 570                 575     
          Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg 
                      580                 585                 590         
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                  595                 600                 605             
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
              610                 615                 620                 
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              770                 775                 780                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
          785                 790                 795                 800 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
                          805                 810                 815     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                      820                 825                 830         
          Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg 
                  835                 840                 845             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
              850                 855                 860                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
          865                 870                 875                 880 
          Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 895     
          His His His His His His 
                      900         
          <![CDATA[<210>  234]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro294 (FL haEGFR2 MMP9 連接子)]]>
          <![CDATA[<400>  234]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                      20                  25                  30          
          Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                      100                 105                 110         
          Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              130                 135                 140                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
          145                 150                 155                 160 
          Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro 
                          165                 170                 175     
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                      180                 185                 190         
          Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser 
                  195                 200                 205             
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
              210                 215                 220                 
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly 
          225                 230                 235                 240 
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                          245                 250                 255     
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      260                 265                 270         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  275                 280                 285             
          Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              290                 295                 300                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          305                 310                 315                 320 
          Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          325                 330                 335     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      340                 345                 350         
          Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  355                 360                 365             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              370                 375                 380                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          385                 390                 395                 400 
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser 
                          405                 410                 415     
          Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                      420                 425                 430         
          Val Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser 
                  435                 440                 445             
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
              450                 455                 460                 
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
          465                 470                 475                 480 
          Cys Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp 
                          485                 490                 495     
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                      500                 505                 510         
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                  515                 520                 525             
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
              530                 535                 540                 
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
          545                 550                 555                 560 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
                          565                 570                 575     
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                      580                 585                 590         
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                  595                 600                 605             
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
              610                 615                 620                 
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
              690                 695                 700                 
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                      740                 745                 750         
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                  755                 760                 765             
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              770                 775                 780                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
          785                 790                 795                 800 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
                          805                 810                 815     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                      820                 825                 830         
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                  835                 840                 845             
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
              850                 855                 860                 
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
          865                 870                 875                 880 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
                          885                 890                 895     
          His His His His His 
                      900     
          <![CDATA[<210>  235]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成]]>構築體 - Pro295 (FL aB7H3 hF7 NC 連接子)
          <![CDATA[<400>  235]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr His Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
                      420                 425                 430         
          Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895 
          <![CDATA[<210>  236]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro296 (FL aB7H3 hF12 NC 連接子)]]>
          <![CDATA[<400>  236]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr Ser Met Ala Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val Ala Ala Ile Asn 
                      420                 425                 430         
          Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Gly 
          465                 470                 475                 480 
          Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
                          485                 490                 495     
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      500                 505                 510         
          Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                  515                 520                 525             
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
              530                 535                 540                 
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
          545                 550                 555                 560 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
                          565                 570                 575     
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                      580                 585                 590         
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                  595                 600                 605             
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
              610                 615                 620                 
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
          625                 630                 635                 640 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                          645                 650                 655     
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                      660                 665                 670         
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                  675                 680                 685             
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
              690                 695                 700                 
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
          705                 710                 715                 720 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                          725                 730                 735     
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                      740                 745                 750         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  755                 760                 765             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              770                 775                 780                 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
          785                 790                 795                 800 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          805                 810                 815     
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                      820                 825                 830         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                  835                 840                 845             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
              850                 855                 860                 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
          865                 870                 875                 880 
          Val Thr Val Ser Ser His His His His His His 
                          885                 890     
          <![CDATA[<210>  237]]>
          <![CDATA[<211>  876]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro297 (FL aFOLR1 h77-2 KLK7.6 連接子)]]>
          <![CDATA[<400>  237]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              370                 375                 380                 
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          385                 390                 395                 400 
          Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala 
                      420                 425                 430         
          Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                  435                 440                 445             
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
              450                 455                 460                 
          Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr 
          465                 470                 475                 480 
          Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gln Asn Pro Tyr Ser Ala 
                          485                 490                 495     
          Gly Arg Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                      500                 505                 510         
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                  515                 520                 525             
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
              530                 535                 540                 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp 
          545                 550                 555                 560 
          Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          565                 570                 575     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      580                 585                 590         
          Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  595                 600                 605             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              610                 615                 620                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          625                 630                 635                 640 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          645                 650                 655     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      660                 665                 670         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  675                 680                 685             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              690                 695                 700                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          705                 710                 715                 720 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          725                 730                 735     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      740                 745                 750         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  755                 760                 765             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              770                 775                 780                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          785                 790                 795                 800 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          805                 810                 815     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      820                 825                 830         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  835                 840                 845             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              850                 855                 860                 
          Leu Val Thr Val Ser Ser His His His His His His 
          865                 870                 875     
          <![CDATA[<210>  238]]>
          <![CDATA[<211>  876]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro298 (FL aFOLR1 h77-2 KLK7.11 連接子)]]>
          <![CDATA[<400>  238]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              370                 375                 380                 
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          385                 390                 395                 400 
          Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala 
                      420                 425                 430         
          Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                  435                 440                 445             
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
              450                 455                 460                 
          Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr 
          465                 470                 475                 480 
          Leu Val Thr Val Ser Ser Ser Gly Gly Gly Arg Asn Val Tyr Ser Ala 
                          485                 490                 495     
          Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                      500                 505                 510         
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                  515                 520                 525             
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
              530                 535                 540                 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp 
          545                 550                 555                 560 
          Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          565                 570                 575     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      580                 585                 590         
          Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  595                 600                 605             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              610                 615                 620                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          625                 630                 635                 640 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          645                 650                 655     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      660                 665                 670         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  675                 680                 685             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              690                 695                 700                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          705                 710                 715                 720 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          725                 730                 735     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      740                 745                 750         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  755                 760                 765             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              770                 775                 780                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          785                 790                 795                 800 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          805                 810                 815     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      820                 825                 830         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  835                 840                 845             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              850                 855                 860                 
          Leu Val Thr Val Ser Ser His His His His His His 
          865                 870                 875     
          <![CDATA[<210>  239]]>
          <![CDATA[<211>  876]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro299 (FL aFOLR1 h77-2 NC 連接子)]]>
          <![CDATA[<400>  239]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              370                 375                 380                 
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          385                 390                 395                 400 
          Val Ser Asn Ser Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala 
                      420                 425                 430         
          Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                  435                 440                 445             
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
              450                 455                 460                 
          Tyr Val Cys Asn Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr 
          465                 470                 475                 480 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                          485                 490                 495     
          Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                      500                 505                 510         
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                  515                 520                 525             
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
              530                 535                 540                 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp 
          545                 550                 555                 560 
          Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          565                 570                 575     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      580                 585                 590         
          Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  595                 600                 605             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              610                 615                 620                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
          625                 630                 635                 640 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
                          645                 650                 655     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                      660                 665                 670         
          Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys 
                  675                 680                 685             
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
              690                 695                 700                 
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
          705                 710                 715                 720 
          Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
                          725                 730                 735     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      740                 745                 750         
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                  755                 760                 765             
          Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
              770                 775                 780                 
          Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
          785                 790                 795                 800 
          Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala 
                          805                 810                 815     
          Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
                      820                 825                 830         
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                  835                 840                 845             
          Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr 
              850                 855                 860                 
          Leu Val Thr Val Ser Ser His His His His His His 
          865                 870                 875     
          <![CDATA[<210>  240]]>
          <![CDATA[<211>  502]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro300 (Pro51 aFOLR1 h77-2)]]>
          <![CDATA[<400>  240]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                  115                 120                 125             
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
              130                 135                 140                 
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val 
          145                 150                 155                 160 
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                          165                 170                 175     
          Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg 
                      180                 185                 190         
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                  195                 200                 205             
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
              210                 215                 220                 
          Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
          225                 230                 235                 240 
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                          245                 250                 255     
          Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              370                 375                 380                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
          385                 390                 395                 400 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
                          405                 410                 415     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                      420                 425                 430         
          Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
          465                 470                 475                 480 
          Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          485                 490                 495     
          His His His His His His 
                      500         
          <![CDATA[<210>  241]]>
          <![CDATA[<211>  874]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro301 (FL aFOLR1 h59.3 KLK7.6 連接子)]]>
          <![CDATA[<400>  241]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              370                 375                 380                 
          Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe 
          385                 390                 395                 400 
          Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
                          405                 410                 415     
          Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp 
                      420                 425                 430         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                  435                 440                 445             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
              450                 455                 460                 
          Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
          465                 470                 475                 480 
          Thr Val Ser Ser Ser Gly Gly Gly Gln Asn Pro Tyr Ser Ala Gly Arg 
                          485                 490                 495     
          Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                      500                 505                 510         
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                  515                 520                 525             
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
              530                 535                 540                 
          Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
          545                 550                 555                 560 
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                          565                 570                 575     
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                      580                 585                 590         
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                  595                 600                 605             
          Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
              610                 615                 620                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
          625                 630                 635                 640 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
                          645                 650                 655     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                      660                 665                 670         
          Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg 
                  675                 680                 685             
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
              690                 695                 700                 
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
          705                 710                 715                 720 
          Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
                          725                 730                 735     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      740                 745                 750         
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                  755                 760                 765             
          Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys 
              770                 775                 780                 
          Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
          785                 790                 795                 800 
          Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser 
                          805                 810                 815     
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
                      820                 825                 830         
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                  835                 840                 845             
          Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val 
              850                 855                 860                 
          Thr Val Ser Ser His His His His His His 
          865                 870                 
          <![CDATA[<210>  242]]>
          <![CDATA[<211>  874]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro302 (FL aFOLR1 h59.3 KLK7.11 連接子)]]>
          <![CDATA[<400>  242]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              370                 375                 380                 
          Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe 
          385                 390                 395                 400 
          Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
                          405                 410                 415     
          Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp 
                      420                 425                 430         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                  435                 440                 445             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
              450                 455                 460                 
          Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
          465                 470                 475                 480 
          Thr Val Ser Ser Ser Gly Gly Gly Arg Asn Val Tyr Ser Ala Gly Gly 
                          485                 490                 495     
          Gly Ser Gly Gly Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                      500                 505                 510         
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                  515                 520                 525             
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
              530                 535                 540                 
          Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
          545                 550                 555                 560 
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                          565                 570                 575     
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                      580                 585                 590         
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                  595                 600                 605             
          Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
              610                 615                 620                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
          625                 630                 635                 640 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
                          645                 650                 655     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                      660                 665                 670         
          Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg 
                  675                 680                 685             
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
              690                 695                 700                 
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
          705                 710                 715                 720 
          Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
                          725                 730                 735     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      740                 745                 750         
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                  755                 760                 765             
          Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys 
              770                 775                 780                 
          Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
          785                 790                 795                 800 
          Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser 
                          805                 810                 815     
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
                      820                 825                 830         
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                  835                 840                 845             
          Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val 
              850                 855                 860                 
          Thr Val Ser Ser His His His His His His 
          865                 870                 
          <![CDATA[<210>  243]]>
          <![CDATA[<211>  874]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro303 (FL aFOLR1 h59.3 NC 連接子)]]>
          <![CDATA[<400>  243]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
              370                 375                 380                 
          Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe 
          385                 390                 395                 400 
          Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
                          405                 410                 415     
          Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp 
                      420                 425                 430         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                  435                 440                 445             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
              450                 455                 460                 
          Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
          465                 470                 475                 480 
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                          485                 490                 495     
          Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                      500                 505                 510         
          Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                  515                 520                 525             
          Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
              530                 535                 540                 
          Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
          545                 550                 555                 560 
          Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                          565                 570                 575     
          Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                      580                 585                 590         
          Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                  595                 600                 605             
          Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
              610                 615                 620                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
          625                 630                 635                 640 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
                          645                 650                 655     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                      660                 665                 670         
          Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg 
                  675                 680                 685             
          Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
              690                 695                 700                 
          Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
          705                 710                 715                 720 
          Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
                          725                 730                 735     
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                      740                 745                 750         
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                  755                 760                 765             
          Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys 
              770                 775                 780                 
          Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
          785                 790                 795                 800 
          Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser 
                          805                 810                 815     
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
                      820                 825                 830         
          Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                  835                 840                 845             
          Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val 
              850                 855                 860                 
          Thr Val Ser Ser His His His His His His 
          865                 870                 
          <![CDATA[<210>  244]]>
          <![CDATA[<211>  501]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro304 (Pro51 aFOLR1 h59.3)]]>
          <![CDATA[<400>  244]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                          245                 250                 255     
          Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                      260                 265                 270         
          Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr 
                  275                 280                 285             
          Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
              290                 295                 300                 
          Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro 
          305                 310                 315                 320 
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                          325                 330                 335     
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                      340                 345                 350         
          Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
                  355                 360                 365             
          Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              370                 375                 380                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
                          405                 410                 415     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                      420                 425                 430         
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
          465                 470                 475                 480 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
                          485                 490                 495     
          His His His His His 
                      500     
          <![CDATA[<210>  245]]>
          <![CDATA[<211>  882]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro305 (FL aFOLR1 h22.4 KLK7.6 連接子)]]>
          <![CDATA[<400>  245]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly 
                          485                 490                 495     
          Arg Asn Val Tyr Ser Ala Gly Gly Gly Ser Gly Gly Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
          545                 550                 555                 560 
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                          565                 570                 575     
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                      580                 585                 590         
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                  595                 600                 605             
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
              610                 615                 620                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          625                 630                 635                 640 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                          645                 650                 655     
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      660                 665                 670         
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
                  675                 680                 685             
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
              690                 695                 700                 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
          705                 710                 715                 720 
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                          725                 730                 735     
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                      740                 745                 750         
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  755                 760                 765             
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
              770                 775                 780                 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
          785                 790                 795                 800 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                          805                 810                 815     
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                      820                 825                 830         
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                  835                 840                 845             
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
              850                 855                 860                 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
          865                 870                 875                 880 
          His His 
          <![CDATA[<210>  246]]>
          <![CDATA[<211>  882]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro306 (FL aFOLR1 h22.4 KLK7.11 連接子)]]>
          <![CDATA[<400>  246]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly 
                          485                 490                 495     
          Arg Asn Val Tyr Ser Ala Gly Gly Gly Ser Gly Gly Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
          545                 550                 555                 560 
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                          565                 570                 575     
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                      580                 585                 590         
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                  595                 600                 605             
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
              610                 615                 620                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          625                 630                 635                 640 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                          645                 650                 655     
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      660                 665                 670         
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
                  675                 680                 685             
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
              690                 695                 700                 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
          705                 710                 715                 720 
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                          725                 730                 735     
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                      740                 745                 750         
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  755                 760                 765             
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
              770                 775                 780                 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
          785                 790                 795                 800 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                          805                 810                 815     
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                      820                 825                 830         
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                  835                 840                 845             
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
              850                 855                 860                 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
          865                 870                 875                 880 
          His His 
          <![CDATA[<210>  247]]>
          <![CDATA[<211>  882]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro307 (FL aFOLR1 h22.4 NC 連接子)]]>
          <![CDATA[<400>  247]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                          485                 490                 495     
          Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
          545                 550                 555                 560 
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                          565                 570                 575     
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                      580                 585                 590         
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                  595                 600                 605             
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
              610                 615                 620                 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
          625                 630                 635                 640 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                          645                 650                 655     
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                      660                 665                 670         
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
                  675                 680                 685             
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
              690                 695                 700                 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
          705                 710                 715                 720 
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                          725                 730                 735     
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                      740                 745                 750         
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  755                 760                 765             
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
              770                 775                 780                 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
          785                 790                 795                 800 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                          805                 810                 815     
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                      820                 825                 830         
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                  835                 840                 845             
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
              850                 855                 860                 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
          865                 870                 875                 880 
          His His 
          <![CDATA[<210>  248]]>
          <![CDATA[<211>  505]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro308 (Pro51 aFOLR1 h22.4)]]>
          <![CDATA[<400>  248]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Leu 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                  115                 120                 125             
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
              130                 135                 140                 
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile 
          145                 150                 155                 160 
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                          165                 170                 175     
          Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val 
                      180                 185                 190         
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
                  195                 200                 205             
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          225                 230                 235                 240 
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                          245                 250                 255     
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                      260                 265                 270         
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
                  275                 280                 285             
          Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
              290                 295                 300                 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 
          305                 310                 315                 320 
          Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                          325                 330                 335     
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                      340                 345                 350         
          Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
                  355                 360                 365             
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
          385                 390                 395                 400 
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
                          405                 410                 415     
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                      420                 425                 430         
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
          465                 470                 475                 480 
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
                          485                 490                 495     
          Val Ser Ser His His His His His His 
                      500                 505 
          <![CDATA[<210>  249]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro335 (FL aEGFR2 NC 連接子)]]>
          <![CDATA[<400>  249]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                      20                  25                  30          
          Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                      100                 105                 110         
          Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              130                 135                 140                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
          145                 150                 155                 160 
          Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro 
                          165                 170                 175     
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
                      180                 185                 190         
          Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser 
                  195                 200                 205             
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
              210                 215                 220                 
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly 
          225                 230                 235                 240 
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                          245                 250                 255     
          Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      260                 265                 270         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  275                 280                 285             
          Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              290                 295                 300                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          305                 310                 315                 320 
          Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          325                 330                 335     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      340                 345                 350         
          Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  355                 360                 365             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              370                 375                 380                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          385                 390                 395                 400 
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser 
                          405                 410                 415     
          Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                      420                 425                 430         
          Val Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser 
                  435                 440                 445             
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
              450                 455                 460                 
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
          465                 470                 475                 480 
          Cys Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp 
                          485                 490                 495     
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                      500                 505                 510         
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                  515                 520                 525             
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
              530                 535                 540                 
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
          545                 550                 555                 560 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
                          565                 570                 575     
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                      580                 585                 590         
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                  595                 600                 605             
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
              610                 615                 620                 
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
              690                 695                 700                 
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                      740                 745                 750         
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                  755                 760                 765             
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              770                 775                 780                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
          785                 790                 795                 800 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
                          805                 810                 815     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                      820                 825                 830         
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                  835                 840                 845             
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
              850                 855                 860                 
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
          865                 870                 875                 880 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
                          885                 890                 895     
          His His His His His 
                      900     
          <![CDATA[<210>  250]]>
          <![CDATA[<211>  894]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro345 (人類化Pro186 Vli2 結構域 MMP9 ]]>
                 連接子)
          <![CDATA[<400>  250]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro 
                      500                 505                 510         
          Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Asp 
                          565                 570                 575     
          Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
          625                 630                 635                 640 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                          645                 650                 655     
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 
                      660                 665                 670         
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                  675                 680                 685             
          Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser 
              690                 695                 700                 
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
          705                 710                 715                 720 
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                          725                 730                 735     
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala 
                      740                 745                 750         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  755                 760                 765             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              770                 775                 780                 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          785                 790                 795                 800 
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                          805                 810                 815     
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                      820                 825                 830         
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                  835                 840                 845             
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
              850                 855                 860                 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
          865                 870                 875                 880 
          Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 
          <![CDATA[<210>  251]]>
          <![CDATA[<211>  894]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro346 (人類化Pro186 Vli2 結構域 NC ]]>
                 連接子)
          <![CDATA[<400>  251]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Asp 
                          565                 570                 575     
          Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                      580                 585                 590         
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                  595                 600                 605             
          Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
              610                 615                 620                 
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
          625                 630                 635                 640 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                          645                 650                 655     
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 
                      660                 665                 670         
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                  675                 680                 685             
          Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser 
              690                 695                 700                 
          Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
          705                 710                 715                 720 
          Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                          725                 730                 735     
          Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala 
                      740                 745                 750         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                  755                 760                 765             
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
              770                 775                 780                 
          Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
          785                 790                 795                 800 
          Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                          805                 810                 815     
          Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu 
                      820                 825                 830         
          Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                  835                 840                 845             
          Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
              850                 855                 860                 
          Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln 
          865                 870                 875                 880 
          Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 
          <![CDATA[<210>  252]]>
          <![CDATA[<211>  880]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro368 (FL aFOLR1 wt22.4 MMP9 連接子)]]>
          <![CDATA[<400>  252]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Gln 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Ala Pro Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Pro 
                          485                 490                 495     
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr 
                      500                 505                 510         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  515                 520                 525             
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              530                 535                 540                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr 
          545                 550                 555                 560 
          Lys Asp Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                          565                 570                 575     
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                      580                 585                 590         
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
                  595                 600                 605             
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
              610                 615                 620                 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          625                 630                 635                 640 
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                          645                 650                 655     
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                      660                 665                 670         
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
                  675                 680                 685             
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
              690                 695                 700                 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
          705                 710                 715                 720 
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                          725                 730                 735     
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                      740                 745                 750         
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                  755                 760                 765             
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
              770                 775                 780                 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
          785                 790                 795                 800 
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                          805                 810                 815     
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                      820                 825                 830         
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
                  835                 840                 845             
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
              850                 855                 860                 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
          865                 870                 875                 880 
          <![CDATA[<210>  253]]>
          <![CDATA[<211>  881]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro369 (FL aFOLR1 wt22.4 KLK7.6 連接子)]]>
          <![CDATA[<400>  253]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Gln 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Ala Pro Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly 
                          485                 490                 495     
          Gln Asn Pro Tyr Ser Ala Gly Arg Gly Gly Gly Ser Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          545                 550                 555                 560 
          Thr Lys Asp Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          565                 570                 575     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      580                 585                 590         
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  595                 600                 605             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              610                 615                 620                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          625                 630                 635                 640 
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                          645                 650                 655     
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                      660                 665                 670         
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
                  675                 680                 685             
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
              690                 695                 700                 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
          705                 710                 715                 720 
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                          725                 730                 735     
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                      740                 745                 750         
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                  755                 760                 765             
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
              770                 775                 780                 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
          785                 790                 795                 800 
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                          805                 810                 815     
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                      820                 825                 830         
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                  835                 840                 845             
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
              850                 855                 860                 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
          865                 870                 875                 880 
          His 
          <![CDATA[<210>  254]]>
          <![CDATA[<211>  881]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro370 (FL aFOLR1 wt22.4 KLK7.11 連接子)]]>
          <![CDATA[<400>  254]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Gln 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Ala Pro Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly 
                          485                 490                 495     
          Arg Asn Val Tyr Ser Ala Gly Gly Gly Ser Gly Gly Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          545                 550                 555                 560 
          Thr Lys Asp Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          565                 570                 575     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      580                 585                 590         
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  595                 600                 605             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              610                 615                 620                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          625                 630                 635                 640 
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                          645                 650                 655     
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                      660                 665                 670         
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
                  675                 680                 685             
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
              690                 695                 700                 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
          705                 710                 715                 720 
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                          725                 730                 735     
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                      740                 745                 750         
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                  755                 760                 765             
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
              770                 775                 780                 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
          785                 790                 795                 800 
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                          805                 810                 815     
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                      820                 825                 830         
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                  835                 840                 845             
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
              850                 855                 860                 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
          865                 870                 875                 880 
          His 
          <![CDATA[<210>  255]]>
          <![CDATA[<211>  881]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro371 (FL aFOLR1 wt22.4 NC 連接子)]]>
          <![CDATA[<400>  255]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Gln 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
                  115                 120                 125             
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
              130                 135                 140                 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn 
          145                 150                 155                 160 
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                          165                 170                 175     
          Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys 
                      180                 185                 190         
          Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                  195                 200                 205             
          Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
              210                 215                 220                 
          Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp 
          225                 230                 235                 240 
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                          245                 250                 255     
          Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                      260                 265                 270         
          Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr 
                  275                 280                 285             
          Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro 
              290                 295                 300                 
          Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala 
          305                 310                 315                 320 
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                          325                 330                 335     
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr 
                      340                 345                 350         
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
          385                 390                 395                 400 
          Gly Thr Thr Phe Ser Arg Asp Val Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Leu Val Ala Ile Ile Ser Arg Gly Gly Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Ala Pro Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Asn Ala Asn Thr Ala Thr Trp Gly Arg Val 
          465                 470                 475                 480 
          Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                          485                 490                 495     
          Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val 
                      500                 505                 510         
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                  515                 520                 525             
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
              530                 535                 540                 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
          545                 550                 555                 560 
          Thr Lys Asp Asp Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          565                 570                 575     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      580                 585                 590         
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  595                 600                 605             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              610                 615                 620                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          625                 630                 635                 640 
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                          645                 650                 655     
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                      660                 665                 670         
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
                  675                 680                 685             
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
              690                 695                 700                 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
          705                 710                 715                 720 
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                          725                 730                 735     
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                      740                 745                 750         
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                  755                 760                 765             
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
              770                 775                 780                 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
          785                 790                 795                 800 
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                          805                 810                 815     
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                      820                 825                 830         
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                  835                 840                 845             
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
              850                 855                 860                 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
          865                 870                 875                 880 
          His 
          <![CDATA[<210>  256]]>
          <![CDATA[<211>  505]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro372 (Pro51 aFOLR1 wt22.4)]]>
          <![CDATA[<400>  256]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser Arg Asp 
                      20                  25                  30          
          Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                  35                  40                  45              
          Ala Ile Ile Ser Arg Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                          85                  90                  95      
          Ala Asn Thr Ala Thr Trp Gly Arg Val Phe Trp Gly Gln Gly Thr Gln 
                      100                 105                 110         
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
                  115                 120                 125             
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
              130                 135                 140                 
          Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile 
          145                 150                 155                 160 
          Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
                          165                 170                 175     
          Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val 
                      180                 185                 190         
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
                  195                 200                 205             
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
              210                 215                 220                 
          Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
          225                 230                 235                 240 
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                          245                 250                 255     
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                      260                 265                 270         
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
                  275                 280                 285             
          Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
              290                 295                 300                 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 
          305                 310                 315                 320 
          Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                          325                 330                 335     
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                      340                 345                 350         
          Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
                  355                 360                 365             
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
          385                 390                 395                 400 
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
                          405                 410                 415     
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                      420                 425                 430         
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
          465                 470                 475                 480 
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
                          485                 490                 495     
          Val Ser Ser His His His His His His 
                      500                 505 
          <![CDATA[<210>  257]]>
          <![CDATA[<211>  895]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構]]>築體 - Pro373 (FL aB7H3 hF7 穿膜肽酶連接子)
          <![CDATA[<400>  257]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr 
                      20                  25                  30          
          His Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Val Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Pro Ser Arg Arg Thr Phe His Thr Tyr His Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
                      420                 425                 430         
          Ile Asn Trp Ser Gly Gly Ser Thr Val Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Gly Ala Thr Thr Gln Arg Ala Thr Glu Ala Ser Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Lys Lys 
                      500                 505                 510         
          Leu Ala Asp Glu Pro Glu Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                  515                 520                 525             
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly 
              530                 535                 540                 
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
          545                 550                 555                 560 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp 
                          565                 570                 575     
          Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
                      580                 585                 590         
          Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
                  595                 600                 605             
          Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 
              610                 615                 620                 
          Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu 
          625                 630                 635                 640 
          Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                          645                 650                 655     
          Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala 
                      660                 665                 670         
          Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                  675                 680                 685             
          Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp 
              690                 695                 700                 
          Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
          705                 710                 715                 720 
          Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                          725                 730                 735     
          Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
                      740                 745                 750         
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                  755                 760                 765             
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
              770                 775                 780                 
          Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
          785                 790                 795                 800 
          Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
                          805                 810                 815     
          Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr 
                      820                 825                 830         
          Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  835                 840                 845             
          Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
              850                 855                 860                 
          Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser 
          865                 870                 875                 880 
          Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895 
          <![CDATA[<210>  258]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro374 (FL aB7H3 hF12 穿膜肽酶連接子)]]>
          <![CDATA[<400>  258]]>
          Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr 
                      20                  25                  30          
          Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val 
                  35                  40                  45              
          Ala Ala Ile Asn Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Gly Gly Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp 
                      100                 105                 110         
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
                  115                 120                 125             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              130                 135                 140                 
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
          145                 150                 155                 160 
          Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          165                 170                 175     
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr 
                      180                 185                 190         
          Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
                  195                 200                 205             
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
              210                 215                 220                 
          Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr Ile Ser 
          225                 230                 235                 240 
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                          245                 250                 255     
          Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      260                 265                 270         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala Ser Ser 
                  275                 280                 285             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              290                 295                 300                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Val 
          305                 310                 315                 320 
          Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
                          325                 330                 335     
          Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                      340                 345                 350         
          Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                  355                 360                 365             
          Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
              370                 375                 380                 
          Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Ser Cys Glu Ala Ser Pro Arg Thr Phe Ser Thr Tyr Ser Met Ala Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Ser Phe Val Ala Ala Ile Asn 
                      420                 425                 430         
          Trp Ser Gly Gly Asn Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Gly 
          465                 470                 475                 480 
          Val Leu Ala His His Asn Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
                          485                 490                 495     
          Leu Val Thr Val Ser Ser Ser Gly Gly Gly Lys Lys Leu Ala Asp Glu 
                      500                 505                 510         
          Pro Glu Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                  515                 520                 525             
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
              530                 535                 540                 
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
          545                 550                 555                 560 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
                          565                 570                 575     
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                      580                 585                 590         
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                  595                 600                 605             
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
              610                 615                 620                 
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
          625                 630                 635                 640 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                          645                 650                 655     
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                      660                 665                 670         
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                  675                 680                 685             
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
              690                 695                 700                 
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
          705                 710                 715                 720 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                          725                 730                 735     
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                      740                 745                 750         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  755                 760                 765             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              770                 775                 780                 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
          785                 790                 795                 800 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          805                 810                 815     
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                      820                 825                 830         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                  835                 840                 845             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
              850                 855                 860                 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
          865                 870                 875                 880 
          Val Thr Val Ser Ser His His His His His His 
                          885                 890     
          <![CDATA[<210>  259]]>
          <![CDATA[<211>  898]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro375 (FL hEGFR1/hEGFR2 穿膜肽酶連接子)]]>
          <![CDATA[<400>  259]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Val Ala 
                      420                 425                 430         
          Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr Glu Tyr 
                          485                 490                 495     
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly 
                      500                 505                 510         
          Gly Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Ser Gln Thr Val Val 
                  515                 520                 525             
          Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
              530                 535                 540                 
          Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
          545                 550                 555                 560 
          Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp 
                          565                 570                 575     
          Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser 
                      580                 585                 590         
          Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                  595                 600                 605             
          Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
              610                 615                 620                 
          Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly 
          625                 630                 635                 640 
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                          645                 650                 655     
          Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
                      660                 665                 670         
          Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                  675                 680                 685             
          Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp 
              690                 695                 700                 
          Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
          705                 710                 715                 720 
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
                          725                 730                 735     
          Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 
                      740                 745                 750         
          Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                  755                 760                 765             
          Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
              770                 775                 780                 
          Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala 
          785                 790                 795                 800 
          Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln 
                          805                 810                 815     
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly 
                      820                 825                 830         
          Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                  835                 840                 845             
          Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
              850                 855                 860                 
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser 
          865                 870                 875                 880 
          Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His 
                          885                 890                 895     
          His His 
          <![CDATA[<210>  260]]>
          <![CDATA[<211>  902]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro376 ]]>(Pro262 穿膜肽酶連接子)
          <![CDATA[<400>  260]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                      260                 265                 270         
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                  275                 280                 285             
          Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
              290                 295                 300                 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
          305                 310                 315                 320 
          Leu Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe 
                          325                 330                 335     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      340                 345                 350         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn 
                  355                 360                 365             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              370                 375                 380                 
          Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser 
          385                 390                 395                 400 
          Val Gln Thr Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg 
                          405                 410                 415     
          Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                      420                 425                 430         
          Glu Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly 
                  435                 440                 445             
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
              450                 455                 460                 
          Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
          465                 470                 475                 480 
          Ala Ile Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr 
                          485                 490                 495     
          Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                      500                 505                 510         
          Ser Ser Gly Gly Gly Lys Lys Leu Ala Asp Glu Pro Glu Gly Gly Ser 
                  515                 520                 525             
          Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
              530                 535                 540                 
          Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
          545                 550                 555                 560 
          Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                          565                 570                 575     
          Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg 
                      580                 585                 590         
          Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
                  595                 600                 605             
          Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser 
              610                 615                 620                 
          Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
          625                 630                 635                 640 
          Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                          645                 650                 655     
          Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                      660                 665                 670         
          Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                  675                 680                 685             
          Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys 
              690                 695                 700                 
          Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
          705                 710                 715                 720 
          Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
                          725                 730                 735     
          Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
                      740                 745                 750         
          Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
                  755                 760                 765             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              770                 775                 780                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
          785                 790                 795                 800 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser 
                          805                 810                 815     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                      820                 825                 830         
          Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg 
                  835                 840                 845             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
              850                 855                 860                 
          Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
          865                 870                 875                 880 
          Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                          885                 890                 895     
          His His His His His His 
                      900         
          <![CDATA[<210>  261]]>
          <![CDATA[<211>  877]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro390 (FL aFOLR1 h59.3 延長之中央 ]]>
                 連接子 MMP9 連接子)
          <![CDATA[<400>  261]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro 
          385                 390                 395                 400 
          Gly Asn Thr Phe Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln 
          465                 470                 475                 480 
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                          485                 490                 495     
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                      500                 505                 510         
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
                  515                 520                 525             
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
              530                 535                 540                 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
          545                 550                 555                 560 
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                          565                 570                 575     
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                      580                 585                 590         
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
                  595                 600                 605             
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
              610                 615                 620                 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
          625                 630                 635                 640 
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                          645                 650                 655     
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                      660                 665                 670         
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
                  675                 680                 685             
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
              690                 695                 700                 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
          705                 710                 715                 720 
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                          725                 730                 735     
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                      740                 745                 750         
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                  755                 760                 765             
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
              770                 775                 780                 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
          785                 790                 795                 800 
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                          805                 810                 815     
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                      820                 825                 830         
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                  835                 840                 845             
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
              850                 855                 860                 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
          865                 870                 875         
          <![CDATA[<210>  262]]>
          <![CDATA[<211>  881]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro391 (FL aFOLR1 h59.3 延長之中央 ]]>
                 連接子及延長之MMP9 連接子)
          <![CDATA[<400>  262]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Asn Thr Phe Ser Ile Ser 
                      20                  25                  30          
          Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
                  35                  40                  45              
          Ala Val Thr His Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                          85                  90                  95      
          His Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                      100                 105                 110         
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                  115                 120                 125             
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
              130                 135                 140                 
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln 
          145                 150                 155                 160 
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                          165                 170                 175     
          Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr 
                      180                 185                 190         
          Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                  195                 200                 205             
          Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn 
              210                 215                 220                 
          Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
          225                 230                 235                 240 
          Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr 
                          245                 250                 255     
          Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
                      260                 265                 270         
          Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr 
                  275                 280                 285             
          Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile 
              290                 295                 300                 
          Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly 
          305                 310                 315                 320 
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                          325                 330                 335     
          Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp 
                      340                 345                 350         
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
                  355                 360                 365             
          Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
              370                 375                 380                 
          Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro 
          385                 390                 395                 400 
          Gly Asn Thr Phe Ser Ile Ser Ala Met Gly Trp Tyr Arg Gln Ala Pro 
                          405                 410                 415     
          Gly Lys Gln Arg Glu Trp Val Ala Val Thr His Ser Asp Tyr Ser Thr 
                      420                 425                 430         
          Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                  435                 440                 445             
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
              450                 455                 460                 
          Thr Ala Val Tyr Tyr Cys Lys His Tyr Gly Ile Asp Tyr Trp Gly Gln 
          465                 470                 475                 480 
          Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly 
                          485                 490                 495     
          Met Lys Gly Leu Pro Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr 
                      500                 505                 510         
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                  515                 520                 525             
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
              530                 535                 540                 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
          545                 550                 555                 560 
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                          565                 570                 575     
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                      580                 585                 590         
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                  595                 600                 605             
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
              610                 615                 620                 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
          625                 630                 635                 640 
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                          645                 650                 655     
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                      660                 665                 670         
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
                  675                 680                 685             
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
              690                 695                 700                 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
          705                 710                 715                 720 
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                          725                 730                 735     
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                      740                 745                 750         
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                  755                 760                 765             
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
              770                 775                 780                 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
          785                 790                 795                 800 
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                          805                 810                 815     
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                      820                 825                 830         
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
                  835                 840                 845             
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
              850                 855                 860                 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
          865                 870                 875                 880 
          His 
          <![CDATA[<210>  263]]>
          <![CDATA[<211>  897]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro412 (具有2aa 延長之中央連接子之Pro186)]]>
          <![CDATA[<400>  263]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
              370                 375                 380                 
          Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser 
          385                 390                 395                 400 
          Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly 
                          405                 410                 415     
          Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                      420                 425                 430         
          Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys 
                  435                 440                 445             
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu 
              450                 455                 460                 
          Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
          465                 470                 475                 480 
          Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr 
                          485                 490                 495     
          Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Gly Pro 
                      500                 505                 510         
          Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr 
                  515                 520                 525             
          Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
              530                 535                 540                 
          Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp 
          545                 550                 555                 560 
          Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr 
                          565                 570                 575     
          Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
                      580                 585                 590         
          Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
                  595                 600                 605             
          Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
              610                 615                 620                 
          Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly 
          625                 630                 635                 640 
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                          645                 650                 655     
          Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
                      660                 665                 670         
          Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                  675                 680                 685             
          Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys 
              690                 695                 700                 
          Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
          705                 710                 715                 720 
          Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala 
                          725                 730                 735     
          Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser 
                      740                 745                 750         
          Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                  755                 760                 765             
          Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
              770                 775                 780                 
          Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
          785                 790                 795                 800 
          Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala 
                          805                 810                 815     
          Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg 
                      820                 825                 830         
          Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                  835                 840                 845             
          Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
              850                 855                 860                 
          Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val 
          865                 870                 875                 880 
          Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His 
                          885                 890                 895     
          His 
          <![CDATA[<210>  264]]>
          <![CDATA[<211>  899]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro413 (具有4aa延長之中央連接子之Pro186)]]>
          <![CDATA[<400>  264]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
              370                 375                 380                 
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          385                 390                 395                 400 
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                          405                 410                 415     
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                      420                 425                 430         
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
                  435                 440                 445             
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
              450                 455                 460                 
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
          465                 470                 475                 480 
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                          485                 490                 495     
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly 
                      500                 505                 510         
          Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln Thr Val 
                  515                 520                 525             
          Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
              530                 535                 540                 
          Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
          545                 550                 555                 560 
          Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                          565                 570                 575     
          Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly 
                      580                 585                 590         
          Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro 
                  595                 600                 605             
          Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp 
              610                 615                 620                 
          Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly 
          625                 630                 635                 640 
          Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                          645                 650                 655     
          Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                      660                 665                 670         
          Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                  675                 680                 685             
          Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp 
              690                 695                 700                 
          Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
          705                 710                 715                 720 
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
                          725                 730                 735     
          Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
                      740                 745                 750         
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                  755                 760                 765             
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
              770                 775                 780                 
          Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
          785                 790                 795                 800 
          Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
                          805                 810                 815     
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
                      820                 825                 830         
          Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                  835                 840                 845             
          Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
              850                 855                 860                 
          Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
          865                 870                 875                 880 
          Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His 
                          885                 890                 895     
          His His His 
          <![CDATA[<210>  265]]>
          <![CDATA[<211>  901]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro414 (具有6aa延長之中央連接子之Pro186)]]>
          <![CDATA[<400>  265]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
              370                 375                 380                 
          Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly 
          385                 390                 395                 400 
          Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser 
                          405                 410                 415     
          Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                      420                 425                 430         
          Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser 
                  435                 440                 445             
          Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
              450                 455                 460                 
          Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
          465                 470                 475                 480 
          Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr 
                          485                 490                 495     
          Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
                      500                 505                 510         
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                  515                 520                 525             
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
              530                 535                 540                 
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
          545                 550                 555                 560 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
                          565                 570                 575     
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                      580                 585                 590         
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                  595                 600                 605             
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
              610                 615                 620                 
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
          625                 630                 635                 640 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                          645                 650                 655     
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                      660                 665                 670         
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                  675                 680                 685             
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
              690                 695                 700                 
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
          705                 710                 715                 720 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
                          725                 730                 735     
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                      740                 745                 750         
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                  755                 760                 765             
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
              770                 775                 780                 
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
          785                 790                 795                 800 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
                          805                 810                 815     
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                      820                 825                 830         
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                  835                 840                 845             
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
              850                 855                 860                 
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
          865                 870                 875                 880 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
                          885                 890                 895     
          His His His His His 
                      900     
          <![CDATA[<210>  266]]>
          <![CDATA[<211>  903]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro415 (具有8aa延長之中央連接子之Pro186)]]>
          <![CDATA[<400>  266]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
              370                 375                 380                 
          Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr 
          385                 390                 395                 400 
          Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
                          405                 410                 415     
          Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                      420                 425                 430         
          Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp 
                  435                 440                 445             
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
              450                 455                 460                 
          Val Asp Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
          465                 470                 475                 480 
          Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu 
                          485                 490                 495     
          Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly 
                      500                 505                 510         
          Gly Gly Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly 
                  515                 520                 525             
          Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
              530                 535                 540                 
          Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
          545                 550                 555                 560 
          Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
                          565                 570                 575     
          Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala 
                      580                 585                 590         
          Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser 
                  595                 600                 605             
          Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr 
              610                 615                 620                 
          Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
          625                 630                 635                 640 
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                          645                 650                 655     
          Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
                      660                 665                 670         
          Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
                  675                 680                 685             
          Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr 
              690                 695                 700                 
          Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
          705                 710                 715                 720 
          Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                          725                 730                 735     
          Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
                      740                 745                 750         
          Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
                  755                 760                 765             
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
              770                 775                 780                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
          785                 790                 795                 800 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met 
                          805                 810                 815     
          Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
                      820                 825                 830         
          Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly 
                  835                 840                 845             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
              850                 855                 860                 
          Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
          865                 870                 875                 880 
          Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                          885                 890                 895     
          Ser His His His His His His 
                      900             
          <![CDATA[<210>  267]]>
          <![CDATA[<211>  893]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro416 (具有2aa縮短之中央連接子之Pro186)]]>
          <![CDATA[<400>  267]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Ser Gly Gly Gly Ser Gln Val Lys 
              370                 375                 380                 
          Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Arg 
          385                 390                 395                 400 
          Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly 
                          405                 410                 415     
          Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile 
                      420                 425                 430         
          Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Ala 
          465                 470                 475                 480 
          Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly 
                          485                 490                 495     
          Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Pro Gly Pro Ala Gly 
                      500                 505                 510         
          Met Lys Gly Leu Pro Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                  515                 520                 525             
          Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
              530                 535                 540                 
          Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
          545                 550                 555                 560 
          Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp 
                          565                 570                 575     
          Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
                      580                 585                 590         
          Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                  595                 600                 605             
          Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
              610                 615                 620                 
          Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
          625                 630                 635                 640 
          Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
                          645                 650                 655     
          Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn 
                      660                 665                 670         
          Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
                  675                 680                 685             
          Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val 
              690                 695                 700                 
          Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
          705                 710                 715                 720 
          Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                          725                 730                 735     
          Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 
                      740                 745                 750         
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                  755                 760                 765             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              770                 775                 780                 
          Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          785                 790                 795                 800 
          Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          805                 810                 815     
          Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr 
                      820                 825                 830         
          Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  835                 840                 845             
          Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
              850                 855                 860                 
          Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly 
          865                 870                 875                 880 
          Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890             
          <![CDATA[<210>  268]]>
          <![CDATA[<211>  891]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro417 (具有4aa縮短之中央連接子之Pro186)]]>
          <![CDATA[<400>  268]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Ser Gly Gly Gly Ser Gln Val Lys Leu 
              370                 375                 380                 
          Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Arg Leu 
          385                 390                 395                 400 
          Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp 
                          405                 410                 415     
          Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile Ser 
                      420                 425                 430         
          Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                  435                 440                 445             
          Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met Asn 
              450                 455                 460                 
          Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Ala Ala 
          465                 470                 475                 480 
          Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln 
                          485                 490                 495     
          Gly Thr Gln Val Thr Val Ser Ser Ser Gly Pro Gly Pro Ala Gly Met 
                      500                 505                 510         
          Lys Gly Leu Pro Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                  515                 520                 525             
          Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
              530                 535                 540                 
          Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
          545                 550                 555                 560 
          Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
                          565                 570                 575     
          Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
                      580                 585                 590         
          Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                  595                 600                 605             
          Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
              610                 615                 620                 
          Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
          625                 630                 635                 640 
          Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
                          645                 650                 655     
          Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                      660                 665                 670         
          Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
                  675                 680                 685             
          Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp 
              690                 695                 700                 
          Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
          705                 710                 715                 720 
          Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                          725                 730                 735     
          His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
                      740                 745                 750         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                  755                 760                 765             
          Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
              770                 775                 780                 
          Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
          785                 790                 795                 800 
          Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                          805                 810                 815     
          Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu 
                      820                 825                 830         
          Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
                  835                 840                 845             
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
              850                 855                 860                 
          Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu 
          865                 870                 875                 880 
          Val Thr Val Ser Ser His His His His His His 
                          885                 890     
          <![CDATA[<210>  269]]>
          <![CDATA[<211>  889]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro418 (具有6aa縮短之中央連接子之Pro186)]]>
          <![CDATA[<400>  269]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gln Val Lys Leu Glu 
              370                 375                 380                 
          Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Arg Leu Thr 
          385                 390                 395                 400 
          Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met Gly Trp Phe 
                          405                 410                 415     
          Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly Ile Ser Trp 
                      420                 425                 430         
          Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                  435                 440                 445             
          Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met Asn Ser 
              450                 455                 460                 
          Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Ala Ala Gly 
          465                 470                 475                 480 
          Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly 
                          485                 490                 495     
          Thr Gln Val Thr Val Ser Ser Gly Pro Gly Pro Ala Gly Met Lys Gly 
                      500                 505                 510         
          Leu Pro Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                  515                 520                 525             
          Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
              530                 535                 540                 
          Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
          545                 550                 555                 560 
          Pro Arg Gly Leu Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr 
                          565                 570                 575     
          Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
                      580                 585                 590         
          Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                  595                 600                 605             
          Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
              610                 615                 620                 
          Leu Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
          625                 630                 635                 640 
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
                          645                 650                 655     
          Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
                      660                 665                 670         
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
                  675                 680                 685             
          Asp Tyr Lys Asp Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe 
              690                 695                 700                 
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
          705                 710                 715                 720 
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
                          725                 730                 735     
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
                      740                 745                 750         
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
                  755                 760                 765             
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
              770                 775                 780                 
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
          785                 790                 795                 800 
          Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                          805                 810                 815     
          Ser Ser Ile Ser Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val 
                      820                 825                 830         
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
                  835                 840                 845             
          Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
              850                 855                 860                 
          Thr Ile Gly Gly Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr 
          865                 870                 875                 880 
          Val Ser Ser His His His His His His 
                          885                 
          <![CDATA[<210>  270]]>
          <![CDATA[<211>  885]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213> ]]> 人工序列
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro420 (FL aFOLR1 h77.2/haEGFR1 ]]>
                 異源性 COBRA MMP9 連接子)
          <![CDATA[<400>  270]]>
          Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser 
                      20                  25                  30          
          Val Met Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ala Ile Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
              50                  55                  60                  
          Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
          65                  70                  75                  80  
          Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn 
                          85                  90                  95      
          Arg Asn Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                      100                 105                 110         
          Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                  115                 120                 125             
          Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
              130                 135                 140                 
          Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg 
          145                 150                 155                 160 
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
                          165                 170                 175     
          Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe 
                      180                 185                 190         
          Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                  195                 200                 205             
          Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Ala 
              210                 215                 220                 
          Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
          225                 230                 235                 240 
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
                          245                 250                 255     
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                      260                 265                 270         
          Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
                  275                 280                 285             
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
              290                 295                 300                 
          Ile Gly Gly Thr Lys Phe Leu Val Pro Gly Thr Pro Ala Arg Phe Ser 
          305                 310                 315                 320 
          Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 
                          325                 330                 335     
          Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg 
                      340                 345                 350         
          Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser 
                  355                 360                 365             
          Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val 
              370                 375                 380                 
          Arg Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr 
          385                 390                 395                 400 
          Ser Arg Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                          405                 410                 415     
          Arg Glu Phe Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr 
                      420                 425                 430         
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                  435                 440                 445             
          Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
              450                 455                 460                 
          Leu Tyr Tyr Cys Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu 
          465                 470                 475                 480 
          Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          485                 490                 495     
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                      500                 505                 510         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  515                 520                 525             
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              530                 535                 540                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          545                 550                 555                 560 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                          565                 570                 575     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      580                 585                 590         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                  595                 600                 605             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              610                 615                 620                 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          625                 630                 635                 640 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                          645                 650                 655     
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                      660                 665                 670         
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
                  675                 680                 685             
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
              690                 695                 700                 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
          705                 710                 715                 720 
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                          725                 730                 735     
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                      740                 745                 750         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
                  755                 760                 765             
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
              770                 775                 780                 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
          785                 790                 795                 800 
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                          805                 810                 815     
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                      820                 825                 830         
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
                  835                 840                 845             
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
              850                 855                 860                 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
          865                 870                 875                 880 
          His His His His His 
                          885 
          <![CDATA[<210>  271]]>
          <![CDATA[<211>  885]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro421 (FL haEGFR1/aFOLR1 h77.2 ]]>
                 異源性 COBRA MMP9 連接子)
          <![CDATA[<400>  271]]>
          Gln Val Lys Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
          1               5                   10                  15      
          Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Ser Val Met 
                          405                 410                 415     
          Ala Trp Tyr Arg Gln Thr Pro Gly Asn Glu Arg Glu Phe Val Ala Ile 
                      420                 425                 430         
          Ile Asn Ser Ile Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
                  435                 440                 445             
          Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
              450                 455                 460                 
          Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Val Cys Asn Arg Asn 
          465                 470                 475                 480 
          Phe Asp Arg Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                          485                 490                 495     
          Ser Gly Gly Pro Gly Pro Ala Gly Met Lys Gly Leu Pro Gly Ser Gln 
                      500                 505                 510         
          Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
                  515                 520                 525             
          Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 
              530                 535                 540                 
          Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 
          545                 550                 555                 560 
          Ile Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe 
                          565                 570                 575     
          Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                      580                 585                 590         
          Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                  595                 600                 605             
          Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
              610                 615                 620                 
          Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
          625                 630                 635                 640 
          Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                          645                 650                 655     
          Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                      660                 665                 670         
          Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp 
                  675                 680                 685             
          Asp Asp Asp Lys Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
              690                 695                 700                 
          Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
          705                 710                 715                 720 
          Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
                          725                 730                 735     
          Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                      740                 745                 750         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
                  755                 760                 765             
          Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu 
              770                 775                 780                 
          Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp 
          785                 790                 795                 800 
          Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser 
                          805                 810                 815     
          Gly Ser Gly Arg Asp Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe 
                      820                 825                 830         
          Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn 
                  835                 840                 845             
          Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly 
              850                 855                 860                 
          Ser Leu Ser Val Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser His 
          865                 870                 875                 880 
          His His His His His 
                          885 
          <![CDATA[<210>  272]]>
          <![CDATA[<211>  896]]>
          <![CDATA[<212>  PRT]]>
          <![CDATA[<213>  人工序列]]>
          <![CDATA[<220>]]>
          <![CDATA[<223>  合成構築體 - Pro429 (Pro186 穿膜肽酶/粒酶B連接子)]]>
          <![CDATA[<400>  272]]>
          Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
          1               5                   10                  15      
          Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                      20                  25                  30          
          Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
                  35                  40                  45              
          Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                          85                  90                  95      
          Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                      100                 105                 110         
          Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
                  115                 120                 125             
          Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
              130                 135                 140                 
          Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
          145                 150                 155                 160 
          Phe Asn Lys Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
                          165                 170                 175     
          Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                      180                 185                 190         
          Tyr Tyr Ala Asp Gln Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
                  195                 200                 205             
          Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
              210                 215                 220                 
          Thr Ala Val Tyr Tyr Cys Val Arg His Ala Asn Phe Gly Asn Ser Tyr 
          225                 230                 235                 240 
          Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                          245                 250                 255     
          Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu 
                      260                 265                 270         
          Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Ala 
                  275                 280                 285             
          Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln 
              290                 295                 300                 
          Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe 
          305                 310                 315                 320 
          Leu Val Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly 
                          325                 330                 335     
          Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu 
                      340                 345                 350         
          Tyr Tyr Cys Thr Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly 
                  355                 360                 365             
          Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
              370                 375                 380                 
          Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
          385                 390                 395                 400 
          Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
                          405                 410                 415     
          Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
                      420                 425                 430         
          Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
                  435                 440                 445             
          Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
              450                 455                 460                 
          Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
          465                 470                 475                 480 
          Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
                          485                 490                 495     
          Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Gly Gly Gly Val Tyr 
                      500                 505                 510         
          Ala Asp Ser Leu Glu Asp Gly Gly Gly Ser Gln Thr Val Val Thr Gln 
                  515                 520                 525             
          Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
              530                 535                 540                 
          Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 
          545                 550                 555                 560 
          Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Asp Tyr Lys 
                          565                 570                 575     
          Asp Asp Asp Asp Lys Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
                      580                 585                 590         
          Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
                  595                 600                 605             
          Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly 
              610                 615                 620                 
          Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Ser Gly Gly Gly Ser 
          625                 630                 635                 640 
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                          645                 650                 655     
          Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
                      660                 665                 670         
          Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                  675                 680                 685             
          Ala Arg Ile Arg Ser Lys Tyr Asp Tyr Lys Asp Asp Asp Asp Lys Ala 
              690                 695                 700                 
          Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
          705                 710                 715                 720 
          Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
                          725                 730                 735     
          Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
                      740                 745                 750         
          Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                  755                 760                 765             
          Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
              770                 775                 780                 
          Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser 
          785                 790                 795                 800 
          Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg Gln Ala Pro 
                          805                 810                 815     
          Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Arg Asp 
                      820                 825                 830         
          Thr Leu Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                  835                 840                 845             
          Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
              850                 855                 860                 
          Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Val Ser 
          865                 870                 875                 880 
          Ser Gln Gly Thr Leu Val Thr Val Ser Ser His His His His His His 
                          885                 890                 895
Figure 12_A0101_SEQ_0001
Figure 12_A0101_SEQ_0002
Figure 12_A0101_SEQ_0003
Figure 12_A0101_SEQ_0004
Figure 12_A0101_SEQ_0005
Figure 12_A0101_SEQ_0006
Figure 12_A0101_SEQ_0007
Figure 12_A0101_SEQ_0008
Figure 12_A0101_SEQ_0009
Figure 12_A0101_SEQ_0010
Figure 12_A0101_SEQ_0011
Figure 12_A0101_SEQ_0012
Figure 12_A0101_SEQ_0013
Figure 12_A0101_SEQ_0014
Figure 12_A0101_SEQ_0015
Figure 12_A0101_SEQ_0016
Figure 12_A0101_SEQ_0017
Figure 12_A0101_SEQ_0018
Figure 12_A0101_SEQ_0019
Figure 12_A0101_SEQ_0020
Figure 12_A0101_SEQ_0021
Figure 12_A0101_SEQ_0022
Figure 12_A0101_SEQ_0023
Figure 12_A0101_SEQ_0024
Figure 12_A0101_SEQ_0025
Figure 12_A0101_SEQ_0026
Figure 12_A0101_SEQ_0027
Figure 12_A0101_SEQ_0028
Figure 12_A0101_SEQ_0029
Figure 12_A0101_SEQ_0030
Figure 12_A0101_SEQ_0031
Figure 12_A0101_SEQ_0032
Figure 12_A0101_SEQ_0033
Figure 12_A0101_SEQ_0034
Figure 12_A0101_SEQ_0035
Figure 12_A0101_SEQ_0036
Figure 12_A0101_SEQ_0037
Figure 12_A0101_SEQ_0038
Figure 12_A0101_SEQ_0039
Figure 12_A0101_SEQ_0040
Figure 12_A0101_SEQ_0041
Figure 12_A0101_SEQ_0042
Figure 12_A0101_SEQ_0043
Figure 12_A0101_SEQ_0044
Figure 12_A0101_SEQ_0045
Figure 12_A0101_SEQ_0046
Figure 12_A0101_SEQ_0047
Figure 12_A0101_SEQ_0048
Figure 12_A0101_SEQ_0049
Figure 12_A0101_SEQ_0050
Figure 12_A0101_SEQ_0051
Figure 12_A0101_SEQ_0052
Figure 12_A0101_SEQ_0053
Figure 12_A0101_SEQ_0054
Figure 12_A0101_SEQ_0055
Figure 12_A0101_SEQ_0056
Figure 12_A0101_SEQ_0057
Figure 12_A0101_SEQ_0058
Figure 12_A0101_SEQ_0059
Figure 12_A0101_SEQ_0060
Figure 12_A0101_SEQ_0061
Figure 12_A0101_SEQ_0062
Figure 12_A0101_SEQ_0063
Figure 12_A0101_SEQ_0064
Figure 12_A0101_SEQ_0065
Figure 12_A0101_SEQ_0066
Figure 12_A0101_SEQ_0067
Figure 12_A0101_SEQ_0068
Figure 12_A0101_SEQ_0069
Figure 12_A0101_SEQ_0070
Figure 12_A0101_SEQ_0071
Figure 12_A0101_SEQ_0072
Figure 12_A0101_SEQ_0073
Figure 12_A0101_SEQ_0074
Figure 12_A0101_SEQ_0075
Figure 12_A0101_SEQ_0076
Figure 12_A0101_SEQ_0077
Figure 12_A0101_SEQ_0078
Figure 12_A0101_SEQ_0079
Figure 12_A0101_SEQ_0080
Figure 12_A0101_SEQ_0081
Figure 12_A0101_SEQ_0082
Figure 12_A0101_SEQ_0083
Figure 12_A0101_SEQ_0084
Figure 12_A0101_SEQ_0085
Figure 12_A0101_SEQ_0086
Figure 12_A0101_SEQ_0087
Figure 12_A0101_SEQ_0088
Figure 12_A0101_SEQ_0089
Figure 12_A0101_SEQ_0090
Figure 12_A0101_SEQ_0091
Figure 12_A0101_SEQ_0092
Figure 12_A0101_SEQ_0093
Figure 12_A0101_SEQ_0094
Figure 12_A0101_SEQ_0095
Figure 12_A0101_SEQ_0096
Figure 12_A0101_SEQ_0097
Figure 12_A0101_SEQ_0098
Figure 12_A0101_SEQ_0099
Figure 12_A0101_SEQ_0100
Figure 12_A0101_SEQ_0101
Figure 12_A0101_SEQ_0102
Figure 12_A0101_SEQ_0103
Figure 12_A0101_SEQ_0104
Figure 12_A0101_SEQ_0105
Figure 12_A0101_SEQ_0106
Figure 12_A0101_SEQ_0107
Figure 12_A0101_SEQ_0108
Figure 12_A0101_SEQ_0109
Figure 12_A0101_SEQ_0110
Figure 12_A0101_SEQ_0111
Figure 12_A0101_SEQ_0112
Figure 12_A0101_SEQ_0113
Figure 12_A0101_SEQ_0114
Figure 12_A0101_SEQ_0115
Figure 12_A0101_SEQ_0116
Figure 12_A0101_SEQ_0117
Figure 12_A0101_SEQ_0118
Figure 12_A0101_SEQ_0119
Figure 12_A0101_SEQ_0120
Figure 12_A0101_SEQ_0121
Figure 12_A0101_SEQ_0122
Figure 12_A0101_SEQ_0123
Figure 12_A0101_SEQ_0124
Figure 12_A0101_SEQ_0125
Figure 12_A0101_SEQ_0126
Figure 12_A0101_SEQ_0127
Figure 12_A0101_SEQ_0128
Figure 12_A0101_SEQ_0129
Figure 12_A0101_SEQ_0130
Figure 12_A0101_SEQ_0131
Figure 12_A0101_SEQ_0132
Figure 12_A0101_SEQ_0133
Figure 12_A0101_SEQ_0134
Figure 12_A0101_SEQ_0135
Figure 12_A0101_SEQ_0136
Figure 12_A0101_SEQ_0137
Figure 12_A0101_SEQ_0138
Figure 12_A0101_SEQ_0139
Figure 12_A0101_SEQ_0140
Figure 12_A0101_SEQ_0141
Figure 12_A0101_SEQ_0142
Figure 12_A0101_SEQ_0143
Figure 12_A0101_SEQ_0144
Figure 12_A0101_SEQ_0145
Figure 12_A0101_SEQ_0146
Figure 12_A0101_SEQ_0147
Figure 12_A0101_SEQ_0148
Figure 12_A0101_SEQ_0149
Figure 12_A0101_SEQ_0150
Figure 12_A0101_SEQ_0151
Figure 12_A0101_SEQ_0152
Figure 12_A0101_SEQ_0153
Figure 12_A0101_SEQ_0154
Figure 12_A0101_SEQ_0155
Figure 12_A0101_SEQ_0156
Figure 12_A0101_SEQ_0157
Figure 12_A0101_SEQ_0158
Figure 12_A0101_SEQ_0159
Figure 12_A0101_SEQ_0160
Figure 12_A0101_SEQ_0161
Figure 12_A0101_SEQ_0162
Figure 12_A0101_SEQ_0163
Figure 12_A0101_SEQ_0164
Figure 12_A0101_SEQ_0165
Figure 12_A0101_SEQ_0166
Figure 12_A0101_SEQ_0167
Figure 12_A0101_SEQ_0168
Figure 12_A0101_SEQ_0169
Figure 12_A0101_SEQ_0170
Figure 12_A0101_SEQ_0171
Figure 12_A0101_SEQ_0172
Figure 12_A0101_SEQ_0173
Figure 12_A0101_SEQ_0174
Figure 12_A0101_SEQ_0175
Figure 12_A0101_SEQ_0176
Figure 12_A0101_SEQ_0177
Figure 12_A0101_SEQ_0178
Figure 12_A0101_SEQ_0179
Figure 12_A0101_SEQ_0180
Figure 12_A0101_SEQ_0181
Figure 12_A0101_SEQ_0182
Figure 12_A0101_SEQ_0183
Figure 12_A0101_SEQ_0184
Figure 12_A0101_SEQ_0185
Figure 12_A0101_SEQ_0186
Figure 12_A0101_SEQ_0187
Figure 12_A0101_SEQ_0188
Figure 12_A0101_SEQ_0189
Figure 12_A0101_SEQ_0190
Figure 12_A0101_SEQ_0191
Figure 12_A0101_SEQ_0192
Figure 12_A0101_SEQ_0193
Figure 12_A0101_SEQ_0194
Figure 12_A0101_SEQ_0195
Figure 12_A0101_SEQ_0196
Figure 12_A0101_SEQ_0197
Figure 12_A0101_SEQ_0198
Figure 12_A0101_SEQ_0199
Figure 12_A0101_SEQ_0200
Figure 12_A0101_SEQ_0201
Figure 12_A0101_SEQ_0202
Figure 12_A0101_SEQ_0203
Figure 12_A0101_SEQ_0204
Figure 12_A0101_SEQ_0205
Figure 12_A0101_SEQ_0206
Figure 12_A0101_SEQ_0207
Figure 12_A0101_SEQ_0208
Figure 12_A0101_SEQ_0209
Figure 12_A0101_SEQ_0210
Figure 12_A0101_SEQ_0211
Figure 12_A0101_SEQ_0212
Figure 12_A0101_SEQ_0213
Figure 12_A0101_SEQ_0214
Figure 12_A0101_SEQ_0215
Figure 12_A0101_SEQ_0216
Figure 12_A0101_SEQ_0217
Figure 12_A0101_SEQ_0218
Figure 12_A0101_SEQ_0219
Figure 12_A0101_SEQ_0220
Figure 12_A0101_SEQ_0221
Figure 12_A0101_SEQ_0222
Figure 12_A0101_SEQ_0223
Figure 12_A0101_SEQ_0224
Figure 12_A0101_SEQ_0225
Figure 12_A0101_SEQ_0226
Figure 12_A0101_SEQ_0227
Figure 12_A0101_SEQ_0228
Figure 12_A0101_SEQ_0229
Figure 12_A0101_SEQ_0230
Figure 12_A0101_SEQ_0231
Figure 12_A0101_SEQ_0232
Figure 12_A0101_SEQ_0233
Figure 12_A0101_SEQ_0234
Figure 12_A0101_SEQ_0235
Figure 12_A0101_SEQ_0236
Figure 12_A0101_SEQ_0237
Figure 12_A0101_SEQ_0238
Figure 12_A0101_SEQ_0239
Figure 12_A0101_SEQ_0240
Figure 12_A0101_SEQ_0241
Figure 12_A0101_SEQ_0242
Figure 12_A0101_SEQ_0243
Figure 12_A0101_SEQ_0244
Figure 12_A0101_SEQ_0245
Figure 12_A0101_SEQ_0246
Figure 12_A0101_SEQ_0247
Figure 12_A0101_SEQ_0248
Figure 12_A0101_SEQ_0249
Figure 12_A0101_SEQ_0250
Figure 12_A0101_SEQ_0251
Figure 12_A0101_SEQ_0252
Figure 12_A0101_SEQ_0253
Figure 12_A0101_SEQ_0254
Figure 12_A0101_SEQ_0255
Figure 12_A0101_SEQ_0256
Figure 12_A0101_SEQ_0257
Figure 12_A0101_SEQ_0258
Figure 12_A0101_SEQ_0259
Figure 12_A0101_SEQ_0260
Figure 12_A0101_SEQ_0261
Figure 12_A0101_SEQ_0262
Figure 12_A0101_SEQ_0263
Figure 12_A0101_SEQ_0264
Figure 12_A0101_SEQ_0265
Figure 12_A0101_SEQ_0266
Figure 12_A0101_SEQ_0267
Figure 12_A0101_SEQ_0268
Figure 12_A0101_SEQ_0269
Figure 12_A0101_SEQ_0270
Figure 12_A0101_SEQ_0271
Figure 12_A0101_SEQ_0272
Figure 12_A0101_SEQ_0273
Figure 12_A0101_SEQ_0274
Figure 12_A0101_SEQ_0275
Figure 12_A0101_SEQ_0276
Figure 12_A0101_SEQ_0277
Figure 12_A0101_SEQ_0278
Figure 12_A0101_SEQ_0279
Figure 12_A0101_SEQ_0280
Figure 12_A0101_SEQ_0281
Figure 12_A0101_SEQ_0282
Figure 12_A0101_SEQ_0283
Figure 12_A0101_SEQ_0284
Figure 12_A0101_SEQ_0285
Figure 12_A0101_SEQ_0286
Figure 12_A0101_SEQ_0287
Figure 12_A0101_SEQ_0288
Figure 12_A0101_SEQ_0289
Figure 12_A0101_SEQ_0290
Figure 12_A0101_SEQ_0291
Figure 12_A0101_SEQ_0292
Figure 12_A0101_SEQ_0293
Figure 12_A0101_SEQ_0294
Figure 12_A0101_SEQ_0295
Figure 12_A0101_SEQ_0296
Figure 12_A0101_SEQ_0297
Figure 12_A0101_SEQ_0298
Figure 12_A0101_SEQ_0299
Figure 12_A0101_SEQ_0300
Figure 12_A0101_SEQ_0301
Figure 12_A0101_SEQ_0302
Figure 12_A0101_SEQ_0303
Figure 12_A0101_SEQ_0304
Figure 12_A0101_SEQ_0305
Figure 12_A0101_SEQ_0306
Figure 12_A0101_SEQ_0307
Figure 12_A0101_SEQ_0308
Figure 12_A0101_SEQ_0309
Figure 12_A0101_SEQ_0310
Figure 12_A0101_SEQ_0311
Figure 12_A0101_SEQ_0312
Figure 12_A0101_SEQ_0313
Figure 12_A0101_SEQ_0314
Figure 12_A0101_SEQ_0315
Figure 12_A0101_SEQ_0316
Figure 12_A0101_SEQ_0317
Figure 12_A0101_SEQ_0318
Figure 12_A0101_SEQ_0319
Figure 12_A0101_SEQ_0320
Figure 12_A0101_SEQ_0321
Figure 12_A0101_SEQ_0322
Figure 12_A0101_SEQ_0323
Figure 12_A0101_SEQ_0324
Figure 12_A0101_SEQ_0325
Figure 12_A0101_SEQ_0326
Figure 12_A0101_SEQ_0327
Figure 12_A0101_SEQ_0328
Figure 12_A0101_SEQ_0329
Figure 12_A0101_SEQ_0330
Figure 12_A0101_SEQ_0331
Figure 12_A0101_SEQ_0332
Figure 12_A0101_SEQ_0333
Figure 12_A0101_SEQ_0334
Figure 12_A0101_SEQ_0335
Figure 12_A0101_SEQ_0336
Figure 12_A0101_SEQ_0337
Figure 12_A0101_SEQ_0338
Figure 12_A0101_SEQ_0339
Figure 12_A0101_SEQ_0340
Figure 12_A0101_SEQ_0341
Figure 12_A0101_SEQ_0342
Figure 12_A0101_SEQ_0343
Figure 12_A0101_SEQ_0344
Figure 12_A0101_SEQ_0345
Figure 12_A0101_SEQ_0346
Figure 12_A0101_SEQ_0347
Figure 12_A0101_SEQ_0348
Figure 12_A0101_SEQ_0349
Figure 12_A0101_SEQ_0350
Figure 12_A0101_SEQ_0351
Figure 12_A0101_SEQ_0352
Figure 12_A0101_SEQ_0353
Figure 12_A0101_SEQ_0354
Figure 12_A0101_SEQ_0355
Figure 12_A0101_SEQ_0356
Figure 12_A0101_SEQ_0357
Figure 12_A0101_SEQ_0358
Figure 12_A0101_SEQ_0359
Figure 12_A0101_SEQ_0360
Figure 12_A0101_SEQ_0361
Figure 12_A0101_SEQ_0362
Figure 12_A0101_SEQ_0363
Figure 12_A0101_SEQ_0364
Figure 12_A0101_SEQ_0365
Figure 12_A0101_SEQ_0366
Figure 12_A0101_SEQ_0367
Figure 12_A0101_SEQ_0368
Figure 12_A0101_SEQ_0369
Figure 12_A0101_SEQ_0370
Figure 12_A0101_SEQ_0371
Figure 12_A0101_SEQ_0372
Figure 12_A0101_SEQ_0373
Figure 12_A0101_SEQ_0374
Figure 12_A0101_SEQ_0375
Figure 12_A0101_SEQ_0376
Figure 12_A0101_SEQ_0377
Figure 12_A0101_SEQ_0378
Figure 12_A0101_SEQ_0379
Figure 12_A0101_SEQ_0380
Figure 12_A0101_SEQ_0381
Figure 12_A0101_SEQ_0382
Figure 12_A0101_SEQ_0383
Figure 12_A0101_SEQ_0384
Figure 12_A0101_SEQ_0385
Figure 12_A0101_SEQ_0386
Figure 12_A0101_SEQ_0387
Figure 12_A0101_SEQ_0388
Figure 12_A0101_SEQ_0389
Figure 12_A0101_SEQ_0390
Figure 12_A0101_SEQ_0391
Figure 12_A0101_SEQ_0392
Figure 12_A0101_SEQ_0393
Figure 12_A0101_SEQ_0394
Figure 12_A0101_SEQ_0395
Figure 12_A0101_SEQ_0396
Figure 12_A0101_SEQ_0397
Figure 12_A0101_SEQ_0398
Figure 12_A0101_SEQ_0399
Figure 12_A0101_SEQ_0400
Figure 12_A0101_SEQ_0401
Figure 12_A0101_SEQ_0402
Figure 12_A0101_SEQ_0403
Figure 12_A0101_SEQ_0404
Figure 12_A0101_SEQ_0405
Figure 12_A0101_SEQ_0406
Figure 12_A0101_SEQ_0407
Figure 12_A0101_SEQ_0408
Figure 12_A0101_SEQ_0409
Figure 12_A0101_SEQ_0410
Figure 12_A0101_SEQ_0411
Figure 12_A0101_SEQ_0412
Figure 12_A0101_SEQ_0413
Figure 12_A0101_SEQ_0414
Figure 12_A0101_SEQ_0415
Figure 12_A0101_SEQ_0416
Figure 12_A0101_SEQ_0417
Figure 12_A0101_SEQ_0418
Figure 12_A0101_SEQ_0419
Figure 12_A0101_SEQ_0420
Figure 12_A0101_SEQ_0421
Figure 12_A0101_SEQ_0422
Figure 12_A0101_SEQ_0423
Figure 12_A0101_SEQ_0424
Figure 12_A0101_SEQ_0425
Figure 12_A0101_SEQ_0426
Figure 12_A0101_SEQ_0427
Figure 12_A0101_SEQ_0428
Figure 12_A0101_SEQ_0429
Figure 12_A0101_SEQ_0430
Figure 12_A0101_SEQ_0431
Figure 12_A0101_SEQ_0432
Figure 12_A0101_SEQ_0433
Figure 12_A0101_SEQ_0434
Figure 12_A0101_SEQ_0435
Figure 12_A0101_SEQ_0436
Figure 12_A0101_SEQ_0437
Figure 12_A0101_SEQ_0438
Figure 12_A0101_SEQ_0439
Figure 12_A0101_SEQ_0440
Figure 12_A0101_SEQ_0441
Figure 12_A0101_SEQ_0442
Figure 12_A0101_SEQ_0443
Figure 12_A0101_SEQ_0444
Figure 12_A0101_SEQ_0445
Figure 12_A0101_SEQ_0446
Figure 12_A0101_SEQ_0447
Figure 12_A0101_SEQ_0448
Figure 12_A0101_SEQ_0449
Figure 12_A0101_SEQ_0450
Figure 12_A0101_SEQ_0451
Figure 12_A0101_SEQ_0452
Figure 12_A0101_SEQ_0453
Figure 12_A0101_SEQ_0454
Figure 12_A0101_SEQ_0455
Figure 12_A0101_SEQ_0456
Figure 12_A0101_SEQ_0457
Figure 12_A0101_SEQ_0458
Figure 12_A0101_SEQ_0459
Figure 12_A0101_SEQ_0460
Figure 12_A0101_SEQ_0461
Figure 12_A0101_SEQ_0462
Figure 12_A0101_SEQ_0463
Figure 12_A0101_SEQ_0464
Figure 12_A0101_SEQ_0465
Figure 12_A0101_SEQ_0466
Figure 12_A0101_SEQ_0467
Figure 12_A0101_SEQ_0468
Figure 12_A0101_SEQ_0469
Figure 12_A0101_SEQ_0470
Figure 12_A0101_SEQ_0471
Figure 12_A0101_SEQ_0472
Figure 12_A0101_SEQ_0473
Figure 12_A0101_SEQ_0474
Figure 12_A0101_SEQ_0475
Figure 12_A0101_SEQ_0476
Figure 12_A0101_SEQ_0477
Figure 12_A0101_SEQ_0478
Figure 12_A0101_SEQ_0479
Figure 12_A0101_SEQ_0480
Figure 12_A0101_SEQ_0481
Figure 12_A0101_SEQ_0482
Figure 12_A0101_SEQ_0483
Figure 12_A0101_SEQ_0484
Figure 12_A0101_SEQ_0485
Figure 12_A0101_SEQ_0486
Figure 12_A0101_SEQ_0487
Figure 12_A0101_SEQ_0488
Figure 12_A0101_SEQ_0489
Figure 12_A0101_SEQ_0490
Figure 12_A0101_SEQ_0491
Figure 12_A0101_SEQ_0492
Figure 12_A0101_SEQ_0493
Figure 12_A0101_SEQ_0494
Figure 12_A0101_SEQ_0495
Figure 12_A0101_SEQ_0496
Figure 12_A0101_SEQ_0497
Figure 12_A0101_SEQ_0498
Figure 12_A0101_SEQ_0499
Figure 12_A0101_SEQ_0500
Figure 12_A0101_SEQ_0501
Figure 12_A0101_SEQ_0502
Figure 12_A0101_SEQ_0503
Figure 12_A0101_SEQ_0504
Figure 12_A0101_SEQ_0505
Figure 12_A0101_SEQ_0506
Figure 12_A0101_SEQ_0507
Figure 12_A0101_SEQ_0508
Figure 12_A0101_SEQ_0509
Figure 12_A0101_SEQ_0510
Figure 12_A0101_SEQ_0511
Figure 12_A0101_SEQ_0512
Figure 12_A0101_SEQ_0513
Figure 12_A0101_SEQ_0514
Figure 12_A0101_SEQ_0515
Figure 12_A0101_SEQ_0516
Figure 12_A0101_SEQ_0517
Figure 12_A0101_SEQ_0518
Figure 12_A0101_SEQ_0519
Figure 12_A0101_SEQ_0520
Figure 12_A0101_SEQ_0521
Figure 12_A0101_SEQ_0522
Figure 12_A0101_SEQ_0523
Figure 12_A0101_SEQ_0524
Figure 12_A0101_SEQ_0525
Figure 12_A0101_SEQ_0526
Figure 12_A0101_SEQ_0527
Figure 12_A0101_SEQ_0528
Figure 12_A0101_SEQ_0529
Figure 12_A0101_SEQ_0530
Figure 12_A0101_SEQ_0531
Figure 12_A0101_SEQ_0532
Figure 12_A0101_SEQ_0533
Figure 12_A0101_SEQ_0534
Figure 12_A0101_SEQ_0535
Figure 12_A0101_SEQ_0536
Figure 12_A0101_SEQ_0537
Figure 12_A0101_SEQ_0538
Figure 12_A0101_SEQ_0539
Figure 12_A0101_SEQ_0540
Figure 12_A0101_SEQ_0541
Figure 12_A0101_SEQ_0542
Figure 12_A0101_SEQ_0543
Figure 12_A0101_SEQ_0544
Figure 12_A0101_SEQ_0545
Figure 12_A0101_SEQ_0546
Figure 12_A0101_SEQ_0547
Figure 12_A0101_SEQ_0548
Figure 12_A0101_SEQ_0549
Figure 12_A0101_SEQ_0550
Figure 12_A0101_SEQ_0551
Figure 12_A0101_SEQ_0552
Figure 12_A0101_SEQ_0553
Figure 12_A0101_SEQ_0554
Figure 12_A0101_SEQ_0555
Figure 12_A0101_SEQ_0556
Figure 12_A0101_SEQ_0557
Figure 12_A0101_SEQ_0558
Figure 12_A0101_SEQ_0559
Figure 12_A0101_SEQ_0560
Figure 12_A0101_SEQ_0561
Figure 12_A0101_SEQ_0562
Figure 12_A0101_SEQ_0563
Figure 12_A0101_SEQ_0564
Figure 12_A0101_SEQ_0565
Figure 12_A0101_SEQ_0566
Figure 12_A0101_SEQ_0567
Figure 12_A0101_SEQ_0568
Figure 12_A0101_SEQ_0569
Figure 12_A0101_SEQ_0570
Figure 12_A0101_SEQ_0571
Figure 12_A0101_SEQ_0572
Figure 12_A0101_SEQ_0573
Figure 12_A0101_SEQ_0574
Figure 12_A0101_SEQ_0575
Figure 12_A0101_SEQ_0576
Figure 12_A0101_SEQ_0577
Figure 12_A0101_SEQ_0578
Figure 12_A0101_SEQ_0579
Figure 12_A0101_SEQ_0580
Figure 12_A0101_SEQ_0581
Figure 12_A0101_SEQ_0582
Figure 12_A0101_SEQ_0583
Figure 12_A0101_SEQ_0584
Figure 12_A0101_SEQ_0585
Figure 12_A0101_SEQ_0586
Figure 12_A0101_SEQ_0587
Figure 12_A0101_SEQ_0588
Figure 12_A0101_SEQ_0589
Figure 12_A0101_SEQ_0590
Figure 12_A0101_SEQ_0591
Figure 12_A0101_SEQ_0592
Figure 12_A0101_SEQ_0593
Figure 12_A0101_SEQ_0594
Figure 12_A0101_SEQ_0595
Figure 12_A0101_SEQ_0596
Figure 12_A0101_SEQ_0597
Figure 12_A0101_SEQ_0598
Figure 12_A0101_SEQ_0599
Figure 12_A0101_SEQ_0600
Figure 12_A0101_SEQ_0601
Figure 12_A0101_SEQ_0602
Figure 12_A0101_SEQ_0603
Figure 12_A0101_SEQ_0604
Figure 12_A0101_SEQ_0605
Figure 12_A0101_SEQ_0606
Figure 12_A0101_SEQ_0607
Figure 12_A0101_SEQ_0608
Figure 12_A0101_SEQ_0609
Figure 12_A0101_SEQ_0610
Figure 12_A0101_SEQ_0611
Figure 12_A0101_SEQ_0612
Figure 12_A0101_SEQ_0613
Figure 12_A0101_SEQ_0614
Figure 12_A0101_SEQ_0615
Figure 12_A0101_SEQ_0616
Figure 12_A0101_SEQ_0617
Figure 12_A0101_SEQ_0618
Figure 12_A0101_SEQ_0619
Figure 12_A0101_SEQ_0620
Figure 12_A0101_SEQ_0621
Figure 12_A0101_SEQ_0622
Figure 12_A0101_SEQ_0623
Figure 12_A0101_SEQ_0624
Figure 12_A0101_SEQ_0625
Figure 12_A0101_SEQ_0626
Figure 12_A0101_SEQ_0627
Figure 12_A0101_SEQ_0628
Figure 12_A0101_SEQ_0629
Figure 12_A0101_SEQ_0630
Figure 12_A0101_SEQ_0631
Figure 12_A0101_SEQ_0632
Figure 12_A0101_SEQ_0633
Figure 12_A0101_SEQ_0634

Claims (49)

  1. 一種蛋白質，其自N端至C端包括： a) 結合至人類腫瘤靶抗原(TTA)之第一單結構域抗原結合結構域(sdABD)(sdABD-TTA)； b) 第一結構域連接子； c) 包括以下之限制性Fv結構域： i)   包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域； ii)  限制性不可裂解連接子(CNCL)；及 iii) 包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域； d) 第二結構域連接子； e) 第二sdABD-TTA； f) 可裂解連接子(CL)； g) 包括以下之限制性假Fv結構域： i)   第一假輕可變結構域； ii)  不可裂解連接子(NCL)；及 iii) 第一假重可變結構域； h) 第三結構域連接子；及 i)   結合至人類血清白蛋白之第三sdABD； 其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且其中所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
  2. 一種蛋白質，其自N端至C端包括： a) 第一sdABD-TTA； b) 第一結構域連接子； c) 包括以下之限制性Fv結構域： i)   包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域； ii)  限制性可裂解連接子(CCL)；及 iii) 包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域； d) 第二結構域連接子； e) 第二sdABD-TTA； f) 可裂解連接子(CL)； g) 包括以下之限制性假Fv結構域： i)   第一假重可變結構域； ii)  不可裂解連接子(NCL)；及 iii) 第一假輕可變結構域； h) 第三結構域連接子；及 i)   結合至人類血清白蛋白之第三sdABD； 其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3；其中所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且其中所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
  3. 如請求項第1項至第2項中任一項所述的蛋白質，其中所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
  4. 如請求項第1項至第2項中任一項所述的蛋白質，其中所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
  5. 如請求項第1項至第2項中任一項所述的蛋白質，其中所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
  6. 如請求項第1項至第2項中任一項所述的蛋白質，其中所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
  7. 如請求項第1項至第6項中任一項所述的蛋白質，其中所述第一及第二TTA為相同的。
  8. 如請求項第1項至第6項中任一項所述的蛋白質，其中所述第一及第二TTA為不同的。
  9. 如請求項第1項至第8項中任一項所述的蛋白質，其中所述第一及第二TTA係選自EGFR、EpCAM、FOLR1及B7H3。
  10. 如請求項第1項至第9項中任一項所述的蛋白質，其中所述第一及第二sdABD-TTA係選自由以下組成之群：SEQ ID NO：1、SEQ ID NO：5、SEQ ID NO：9、SEQ ID NO：13、SEQ ID NO：17、SEQ ID NO：21、SEQ ID NO：25、SEQ ID NO：29；SEQ ID NO：33；SEQ ID NO：37及SEQ ID NO：41。
  11. 如請求項第1項至第10項所述的蛋白質，其中所述半衰期延長結構域具有SEQ ID NO：45。
  12. 如請求項第1項至第11項所述的蛋白質，其中所述可裂解連接子係經選自由以下組成之群之人類蛋白酶裂解：MMP2、MMP9、穿膜肽酶A、穿膜肽酶B、組織蛋白酶S、組織蛋白酶K、組織蛋白酶L、粒酶B、uPA、激肽釋放酶7、間質蛋白酶及凝血酶。
  13. 如請求項第1項所述的蛋白質，其包括選自由以下組成之群之蛋白質：Pro186、Pro225、Pro226、Pro233、Pro311、Pro312、Pro313、Pro495、Pro246、Pro254、Pro255、Pro256、Pro420、Pro421、Pro432、Pro479、Pro480、Pro187、Pro221、Pro222、Pro223、Pro224、Pro393、Pro394、Pro395、Pro396、Pro429、Pro430及Pro431。
  14. 一種核酸，其編碼如請求項第1項至第13項中任一項所述的蛋白質。
  15. 一種表現載體，其包括如請求項第14項所述的核酸。
  16. 一種宿主細胞，其包括如請求項第15項所述的表現載體。
  17. 一種製備蛋白質之方法，其包括在其中所述蛋白質得到表現之條件下培養如請求項第16項所述的宿主細胞且回收所述蛋白質。
  18. 一種治療癌症之方法，其包括將如請求項第1項至第13項所述的蛋白質投予至患者。
  19. 一種組合物，其包括： a) 自N端至C端包括以下之第一蛋白質： i)   第一sdABD-TTA； ii)  第一結構域連接子； iii) 自N端至C端包括以下之假Fv 結構域： 1) 包括vhCDR1、vhCDR2 及vhCDR3之可變重鏈； 2) 可裂解連接子； 及 3) 包括iVLCDR1 、iVLCDR2 及iVLCDR3之第一假可變輕結構域； iv) 第二結構域連接子； v)  結合至人類血清白蛋白之第一sdABD； b) 自N端至C端包括以下之第二蛋白質： i)   結合至人類腫瘤靶抗原之第三sdABD； ii)  第三結構域連接子； iii) 自N端至C端包括以下之假Fv結構域： 1) 包括VLCDR1 、VLCDR2及VLCDR3之可變輕鏈； 2) 可裂解連接子； 及 3) 包括iVHCDR1、iVHCDR2及iVHCDR3之第一假可變重結構域； iv) 第四結構域連接子； v)  結合至人類血清白蛋白之第四sdABD； 其中 所述第一可變重結構域及所述第一可變輕結構域在締合時能夠結合人類CD3； 所述第一可變重結構域與所述第一假可變輕結構域進行分子間締合以形成非活性Fv； 所述第一可變輕結構域與所述第一假可變重結構域進行分子間締合以形成非活性Fv ； 其中所述第一及第三sdABD係選自由以下組成之群： SEQ ID NO： 1 、SEQ ID NO： 5 、SEQ ID NO： 9 、SEQ ID NO ： 13 、SEQ ID NO ： 17 、SEQ ID NO ： 21 、SEQ ID NO ： 25 、SEQ ID NO ： 29 ； SEQ ID NO ： 33 ； SEQ ID NO： 37 及SEQ ID NO： 41 。
  20. 如請求項第19項所述的蛋白質，其中所述第一及第二TTA為相同的。
  21. 如請求項第19項所述的蛋白質， 其中所述第一及第二TTA為不同的。
  22. 如請求項第19項至第21項中任一項所述的蛋白質，其中所述第三及第四sdABD具有SEQ ID NO：45 。
  23. 一種核酸組合物，其包括： a) 編碼如請求項第19項至第22項中任一項所述的第一蛋白質之第一核酸；及 b) 編碼如請求項第19項至第22項中任一項所述的第二蛋白質之第二核酸。
  24. 一種表現載體組合物，其包括： a) 包括如請求項第23項所述的第一核酸之第一表現載體；及 b) 包括如請求項第23項所述的第二核酸之第二表現載體。
  25. 一種宿主細胞，其包括如請求項第24項所述的表現載體組合物。
  26. 一種製備組合物之方法，其包括在其中所述蛋白質得到表現之條件下培養如請求項第25項所述的宿主細胞且回收所述蛋白質。
  27. 一種治療癌症之方法，其包括將如請求項第19項至第22項中任一項所述的蛋白質投予至患者。
  28. 一種組合物，其包括： a) 自N端至C端包括以下之第一蛋白質： i) 第一sdABD-TTA； ii) 第一結構域連接子； iii) 第二sdABD-TTA； iv) 第二結構域連接子； v) 自N端至C端包括以下之假Fv結構域： 1) 包括vhCDR1、vhCDR2及vhCDR3之可變重鏈； 2) 可裂解連接子；及 3) 包括iVLCDR1、iVLCDR2及iVLCDR3之第一假可變輕結構域； vi) 第三結構域連接子；及 vii) sdABD-HSA； b) 自N端至C端包括以下之第二蛋白質： i) 第三sdABD-TTA； ii) 第四結構域連接子； iii) 第四sdABD-TTA； iv) 第五結構域連接子； v) 自N端至C端包括以下之假Fv結構域： 1) 包括VLCDR1、VLCDR2及VLCDR3之可變輕鏈； 2) 可裂解連接子；及 3) 包括iVHCDR1、iVHCDR2及iVHCDR3之第一假可變重結構域； vi) 第六結構域連接子； vii) sdABD-HSA； 其中 所述第一可變重結構域及所述第一可變輕結構域在締合時能夠結合人類CD3； 行分子間締合以形成非活性Fv； 所述第一可變輕結構域與所述第一假可變重結構域進行分子間締合以形成非活性Fv。
  29. 如請求項第28項所述的組合物，其中所述sdABD-HSA具有SEQ ID NO：45。
  30. 一種核酸組合物，其包括： a) 編碼如請求項第28項至第29項中任一項所述的第一蛋白質之第一核酸；及 b) 編碼如請求項第28項至第29項中任一項所述的第二蛋白質之第二核酸。
  31. 一種表現載體組合物，其包括： a) 包括如請求項第30項所述的第一核酸之第一表現載體；及 b) 包括如請求項第30項所述的第二核酸之第二表現載體。
  32. 一種宿主細胞，其包括如請求項第31項所述的表現載體組合物。
  33. 一種製備組合物之方法，其包括在其中所述蛋白質得到表現之條件下培養如請求項第32項所述的宿主細胞且回收所述蛋白質。
  34. 一種治療癌症之方法，其包括將如請求項第28項至第29項中任一項所述的蛋白質投予至患者。
  35. 一種蛋白質，其自N端至C端包括： a) 結合至人類腫瘤靶抗原(TTA)之單結構域抗原結合結構域(sdABD)(sdABD-TTA)； b) 第一結構域連接子； c) 包括以下之限制性Fv結構域： i) 包括vhCDR1、vhCDR2及vhCDR3之第一可變重結構域； ii) 限制性不可裂解連接子(CNCL)；及 iii) 包括vlCDR1、vlCDR2及vlCDR3之第一可變輕結構域； d) 可裂解連接子(CL)； e) 結合至人類血清白蛋白之第二sdABD； f) 結構域連接子； g) 包括以下之限制性假Fv結構域： i) 第一假輕可變結構域； ii) 不可裂解連接子(NCL)；及 iii) 第一假重可變結構域； 其中所述第一可變重結構域及所述第一可變輕結構域能夠結合人類CD3，但所述限制性Fv結構域不結合CD3； 所述第一可變重結構域與所述第一假可變輕結構域進行分子內締合以形成非活性Fv；且 所述第一可變輕結構域與所述第一假可變重結構域進行分子內締合以形成非活性Fv。
  36. 如請求項第35項所述的蛋白質，其中所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
  37. 如請求項第35項所述的蛋白質，其中所述第一可變重結構域為所述第一可變輕結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
  38. 如請求項第35項所述的蛋白質，其中所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假輕可變結構域為所述假可變重結構域之N端。
  39. 如請求項第35項所述的蛋白質，其中所述第一可變輕結構域為所述第一可變重結構域之N端，且所述假可變重結構域為所述假可變輕結構域之N端。
  40. 如請求項第35項至第39項所述的蛋白質，其中所述TTA係選自EGFR、EpCAM、FOLR1及B7H3。
  41. 如請求項第35項至第40項中任一項所述的蛋白質，其中所述sdABD-TTA係選自由以下組成之群：SEQ ID NO：1、SEQ ID NO：5、SEQ ID NO：9、SEQ ID NO：13、SEQ ID NO：17、SEQ ID NO：21、SEQ ID NO：25、SEQ ID NO：29；SEQ ID NO：33；SEQ ID NO：37及SEQ ID NO：41。
  42. 如請求項第35項至第41項中任一項所述的蛋白質，其中所述半衰期延長結構域具有SEQ ID NO：45。
  43. 如請求項第35項至第42項中任一項所述的蛋白質，其中所述可裂解連接子係經選自由以下組成之群之人類蛋白酶裂解：MMP2、MMP9、穿膜肽酶A、穿膜肽酶B、組織蛋白酶S、組織蛋白酶K、組織蛋白酶L、粒酶B、uPA、激肽釋放酶7、間質蛋白酶及凝血酶。
  44. 如請求項第35項所述的蛋白質，其包括Pro258、Pro356、Pro359、Pro388及Pro364。
  45. 一種核酸，其編碼如請求項第35項至第44項中任一項所述的蛋白質。
  46. 一種表現載體，其包括如請求項第57項所述的核酸。
  47. 一種宿主細胞，其包括如請求項第46項所述的表現載體。
  48. 一種製備蛋白質之方法，其包括在其中所述蛋白質得到表現之條件下培養如請求項第47項所述的宿主細胞且回收所述蛋白質。
  49. 一種治療癌症之方法，其包括將如請求項第35項至第44項中任一項所述的蛋白質投予至患者。
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