TW201822803A - 一種抑制胰島β細胞凋亡的方法 - Google Patents

一種抑制胰島β細胞凋亡的方法 Download PDF

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Publication number
TW201822803A
TW201822803A TW106120484A TW106120484A TW201822803A TW 201822803 A TW201822803 A TW 201822803A TW 106120484 A TW106120484 A TW 106120484A TW 106120484 A TW106120484 A TW 106120484A TW 201822803 A TW201822803 A TW 201822803A
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Taiwan
Prior art keywords
plasminogen
mice
group
pbs
control group
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TW106120484A
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English (en)
Chinese (zh)
Inventor
李季男
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深圳瑞健生命科學硏究院有限公司
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Publication of TW201822803A publication Critical patent/TW201822803A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
TW106120484A 2016-12-15 2017-06-19 一種抑制胰島β細胞凋亡的方法 TW201822803A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15

Publications (1)

Publication Number Publication Date
TW201822803A true TW201822803A (zh) 2018-07-01

Family

ID=62557852

Family Applications (7)

Application Number Title Priority Date Filing Date
TW106120484A TW201822803A (zh) 2016-12-15 2017-06-19 一種抑制胰島β細胞凋亡的方法
TW106120482A TWI644682B (zh) 2016-12-15 2017-06-19 一種纖溶酶原在製備促進胰島細胞損傷修復的藥物上的用途
TW106120494A TWI669130B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備用於治療糖尿病的藥物上的用途
TW106120481A TWI763680B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120493A TWI763681B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120485A TWI642442B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備降低胰高血糖素分泌的藥物上的用途
TW106120480A TWI738799B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途

Family Applications After (6)

Application Number Title Priority Date Filing Date
TW106120482A TWI644682B (zh) 2016-12-15 2017-06-19 一種纖溶酶原在製備促進胰島細胞損傷修復的藥物上的用途
TW106120494A TWI669130B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備用於治療糖尿病的藥物上的用途
TW106120481A TWI763680B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120493A TWI763681B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途
TW106120485A TWI642442B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備降低胰高血糖素分泌的藥物上的用途
TW106120480A TWI738799B (zh) 2016-12-15 2017-06-19 纖溶酶原在製備藥物中的用途

Country Status (9)

Country Link
US (4) US11129880B2 (enExample)
EP (4) EP3556392B1 (enExample)
JP (6) JP7175270B2 (enExample)
CN (4) CN110139667A (enExample)
CA (4) CA3047176C (enExample)
DK (1) DK3556383T5 (enExample)
ES (1) ES2981141T3 (enExample)
TW (7) TW201822803A (enExample)
WO (7) WO2018107701A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10709771B2 (en) 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
US11090372B2 (en) 2015-12-18 2021-08-17 Talengen International Limited Method of treating diabetic nephropathy comprising administering plasminogen
US11129880B2 (en) 2016-12-15 2021-09-28 Talengen International Limited Method for promoting insulin secretion
US11338022B2 (en) 2015-12-18 2022-05-24 Talengen International Limited Method for preventing and treating angiocardiopathy
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen

Families Citing this family (3)

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JP7213552B2 (ja) 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
CA3067890A1 (en) * 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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TWI750189B (zh) 2016-12-15 2021-12-21 大陸商深圳瑞健生命科學研究院有限公司 一種治療冠狀動脈粥樣硬化及其併發症的方法
WO2018107701A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种新的降血糖和提高糖耐量的药物
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10709771B2 (en) 2015-12-18 2020-07-14 Talengen International Limited Method for preventing or treating diabetic retinopathy
US11090372B2 (en) 2015-12-18 2021-08-17 Talengen International Limited Method of treating diabetic nephropathy comprising administering plasminogen
US11338022B2 (en) 2015-12-18 2022-05-24 Talengen International Limited Method for preventing and treating angiocardiopathy
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
US11129880B2 (en) 2016-12-15 2021-09-28 Talengen International Limited Method for promoting insulin secretion
US11311607B2 (en) 2016-12-15 2022-04-26 Talengen International Limited Method for making glucagon and insulin restore normal balance

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WO2018107703A1 (zh) 2018-06-21
JP2020502150A (ja) 2020-01-23
JP2020510628A (ja) 2020-04-09
WO2018107701A1 (zh) 2018-06-21
JP7171572B2 (ja) 2022-11-15
EP3556392B1 (en) 2024-04-17
US20190314464A1 (en) 2019-10-17
US20190307861A1 (en) 2019-10-10
JP2020502151A (ja) 2020-01-23
US20190314465A1 (en) 2019-10-17
CN110198732A (zh) 2019-09-03
US20190314463A1 (en) 2019-10-17
EP3556383A4 (en) 2020-09-09
CN110121357A (zh) 2019-08-13
EP3556390B1 (en) 2024-04-03
EP3556392A4 (en) 2020-09-23
EP3556384A1 (en) 2019-10-23
TW201822802A (zh) 2018-07-01
JP2020502140A (ja) 2020-01-23
CA3047176C (en) 2021-11-30
CA3047177A1 (en) 2018-06-21
EP3556392A1 (en) 2019-10-23
JP2022166026A (ja) 2022-11-01
WO2018107706A1 (zh) 2018-06-21
US11311607B2 (en) 2022-04-26
JP7554557B2 (ja) 2024-09-20
CA3047176A1 (en) 2018-06-21
JP7175270B2 (ja) 2022-11-18
EP3556390A4 (en) 2020-09-09
TWI642442B (zh) 2018-12-01
CA3047172A1 (en) 2018-06-21
CA3047173A1 (en) 2018-06-21
TW201822807A (zh) 2018-07-01
WO2018107702A1 (zh) 2018-06-21
TWI669130B (zh) 2019-08-21
JP7554048B2 (ja) 2024-09-19
EP3556383A1 (en) 2019-10-23
CN110139667A (zh) 2019-08-16
TWI763681B (zh) 2022-05-11
TW201822808A (zh) 2018-07-01
TW201822804A (zh) 2018-07-01
EP3556384B1 (en) 2024-04-10
WO2018107705A1 (zh) 2018-06-21
CN110366426A (zh) 2019-10-22
US11129880B2 (en) 2021-09-28
DK3556383T5 (da) 2024-09-02
ES2981141T3 (es) 2024-10-07
EP3556390A1 (en) 2019-10-23
EP3556384A4 (en) 2020-09-23
JP2022166028A (ja) 2022-11-01
TW201822801A (zh) 2018-07-01
TWI738799B (zh) 2021-09-11
TWI644682B (zh) 2018-12-21
WO2018107708A1 (zh) 2018-06-21
TWI763680B (zh) 2022-05-11
WO2018107704A1 (zh) 2018-06-21
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TW201822800A (zh) 2018-07-01
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