ES2981141T3 - Plasminógeno para su uso en el tratamiento de la diabetes - Google Patents

Plasminógeno para su uso en el tratamiento de la diabetes Download PDF

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Publication number
ES2981141T3
ES2981141T3 ES17880561T ES17880561T ES2981141T3 ES 2981141 T3 ES2981141 T3 ES 2981141T3 ES 17880561 T ES17880561 T ES 17880561T ES 17880561 T ES17880561 T ES 17880561T ES 2981141 T3 ES2981141 T3 ES 2981141T3
Authority
ES
Spain
Prior art keywords
plasminogen
administered
mice
group
control group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17880561T
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English (en)
Spanish (es)
Inventor
Jinan Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talengen International Ltd
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Talengen International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of ES2981141T3 publication Critical patent/ES2981141T3/es
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
ES17880561T 2016-12-15 2017-06-19 Plasminógeno para su uso en el tratamiento de la diabetes Active ES2981141T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089062 WO2018107702A1 (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Publications (1)

Publication Number Publication Date
ES2981141T3 true ES2981141T3 (es) 2024-10-07

Family

ID=62557852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17880561T Active ES2981141T3 (es) 2016-12-15 2017-06-19 Plasminógeno para su uso en el tratamiento de la diabetes

Country Status (9)

Country Link
US (4) US11129880B2 (enExample)
EP (4) EP3556392B1 (enExample)
JP (6) JP7175270B2 (enExample)
CN (4) CN110139667A (enExample)
CA (4) CA3047176C (enExample)
DK (1) DK3556383T5 (enExample)
ES (1) ES2981141T3 (enExample)
TW (7) TWI763680B (enExample)
WO (7) WO2018107706A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778320A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗心血管病的新方法
DK3395354T3 (da) 2015-12-18 2024-06-03 Talengen Int Ltd Plasminogen til anvendelse i behandling af diabetisk nefropati
ES3046932T3 (en) 2015-12-18 2025-12-02 Talengen Int Ltd Plasminogen preventing or treating diabetic retinopathy
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
CA3047176C (en) 2016-12-15 2021-11-30 Talengen International Limited Use of plasminogen for promoting secretion of insulin in treatment of diabetes
TWI734798B (zh) 2016-12-15 2021-08-01 大陸商深圳瑞健生命科學研究院有限公司 一種預防和治療肺纖維化的方法
ES3036897T3 (en) * 2017-06-19 2025-09-25 Talengen Int Ltd Plasminogen for use in treating parkinson's and alzheimer's disease
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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ES3046932T3 (en) 2015-12-18 2025-12-02 Talengen Int Ltd Plasminogen preventing or treating diabetic retinopathy
DK3395354T3 (da) 2015-12-18 2024-06-03 Talengen Int Ltd Plasminogen til anvendelse i behandling af diabetisk nefropati
TWI750189B (zh) 2016-12-15 2021-12-21 大陸商深圳瑞健生命科學研究院有限公司 一種治療冠狀動脈粥樣硬化及其併發症的方法
CA3047176C (en) 2016-12-15 2021-11-30 Talengen International Limited Use of plasminogen for promoting secretion of insulin in treatment of diabetes
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Also Published As

Publication number Publication date
TWI738799B (zh) 2021-09-11
JP7554048B2 (ja) 2024-09-19
TWI669130B (zh) 2019-08-21
WO2018107703A1 (zh) 2018-06-21
WO2018107708A1 (zh) 2018-06-21
TWI763681B (zh) 2022-05-11
EP3556383A1 (en) 2019-10-23
JP2020502150A (ja) 2020-01-23
TW201822808A (zh) 2018-07-01
EP3556392B1 (en) 2024-04-17
US20190314464A1 (en) 2019-10-17
US20190307861A1 (en) 2019-10-10
TW201822804A (zh) 2018-07-01
CN110121357A (zh) 2019-08-13
WO2018107705A1 (zh) 2018-06-21
TW201822807A (zh) 2018-07-01
JP2022166026A (ja) 2022-11-01
JP7175270B2 (ja) 2022-11-18
TW201822800A (zh) 2018-07-01
CN110139667A (zh) 2019-08-16
EP3556383B1 (en) 2024-04-10
US11311607B2 (en) 2022-04-26
CA3047176C (en) 2021-11-30
EP3556384A4 (en) 2020-09-23
JP2020510628A (ja) 2020-04-09
US20190314463A1 (en) 2019-10-17
EP3556390B1 (en) 2024-04-03
TWI763680B (zh) 2022-05-11
TW201822802A (zh) 2018-07-01
CA3047173A1 (en) 2018-06-21
DK3556383T5 (da) 2024-09-02
DK3556383T3 (da) 2024-05-13
TWI644682B (zh) 2018-12-21
EP3556384A1 (en) 2019-10-23
TW201822803A (zh) 2018-07-01
EP3556390A1 (en) 2019-10-23
WO2018107706A1 (zh) 2018-06-21
CA3047172A1 (en) 2018-06-21
US11129880B2 (en) 2021-09-28
US20190314465A1 (en) 2019-10-17
JP2022166028A (ja) 2022-11-01
WO2018107704A1 (zh) 2018-06-21
TW201822801A (zh) 2018-07-01
EP3556383A4 (en) 2020-09-09
EP3556392A4 (en) 2020-09-23
JP2020502151A (ja) 2020-01-23
EP3556384B1 (en) 2024-04-10
CA3047177A1 (en) 2018-06-21
EP3556390A4 (en) 2020-09-09
TWI642442B (zh) 2018-12-01
CN110366426A (zh) 2019-10-22
EP3556392A1 (en) 2019-10-23
WO2018107702A1 (zh) 2018-06-21
CN110198732A (zh) 2019-09-03
JP7171572B2 (ja) 2022-11-15
JP7554557B2 (ja) 2024-09-20
JP2020502140A (ja) 2020-01-23
WO2018107701A1 (zh) 2018-06-21
CA3047176A1 (en) 2018-06-21

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