CA3047172A1 - Novel method for treating diabetes - Google Patents

Novel method for treating diabetes Download PDF

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Publication number
CA3047172A1
CA3047172A1 CA3047172A CA3047172A CA3047172A1 CA 3047172 A1 CA3047172 A1 CA 3047172A1 CA 3047172 A CA3047172 A CA 3047172A CA 3047172 A CA3047172 A CA 3047172A CA 3047172 A1 CA3047172 A1 CA 3047172A1
Authority
CA
Canada
Prior art keywords
plasminogen
subject
mice
pancreatic islet
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3047172A
Other languages
English (en)
French (fr)
Inventor
Jinan Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Talengen International Ltd
Original Assignee
Talengen International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talengen International Ltd filed Critical Talengen International Ltd
Publication of CA3047172A1 publication Critical patent/CA3047172A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3047172A 2016-12-15 2017-06-19 Novel method for treating diabetes Abandoned CA3047172A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089062 WO2018107702A1 (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Publications (1)

Publication Number Publication Date
CA3047172A1 true CA3047172A1 (en) 2018-06-21

Family

ID=62557852

Family Applications (4)

Application Number Title Priority Date Filing Date
CA3047172A Abandoned CA3047172A1 (en) 2016-12-15 2017-06-19 Novel method for treating diabetes
CA3047173A Abandoned CA3047173A1 (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting insulin secretion for treatment of diabetes
CA3047177A Abandoned CA3047177A1 (en) 2016-12-15 2017-06-19 Method for promoting expression of insulin receptor substrate-2
CA3047176A Active CA3047176C (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting secretion of insulin in treatment of diabetes

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA3047173A Abandoned CA3047173A1 (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting insulin secretion for treatment of diabetes
CA3047177A Abandoned CA3047177A1 (en) 2016-12-15 2017-06-19 Method for promoting expression of insulin receptor substrate-2
CA3047176A Active CA3047176C (en) 2016-12-15 2017-06-19 Use of plasminogen for promoting secretion of insulin in treatment of diabetes

Country Status (9)

Country Link
US (4) US20190314464A1 (enExample)
EP (4) EP3556392B1 (enExample)
JP (6) JP7554048B2 (enExample)
CN (4) CN110366426A (enExample)
CA (4) CA3047172A1 (enExample)
DK (1) DK3556383T5 (enExample)
ES (1) ES2981141T3 (enExample)
TW (7) TWI763681B (enExample)
WO (7) WO2018107702A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11338022B2 (en) 2015-12-18 2022-05-24 Talengen International Limited Method for preventing and treating angiocardiopathy

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3008694C (en) 2015-12-18 2022-11-29 Talengen International Limited Use of plasminogen for preventing or treating diabetic nerve injury and related disorders thereof
DK3395354T3 (da) 2015-12-18 2024-06-03 Talengen Int Ltd Plasminogen til anvendelse i behandling af diabetisk nefropati
TWI624267B (zh) 2015-12-18 2018-05-21 Talengen Institute Of Life Sciences Co Ltd 纖溶酶原在製備預防或治療糖尿病性視網膜病變的藥劑上的用途及包括纖溶酶原用於預防或治療糖尿病性視網膜病變之藥劑
TWI734798B (zh) 2016-12-15 2021-08-01 大陸商深圳瑞健生命科學研究院有限公司 一種預防和治療肺纖維化的方法
TWI763681B (zh) * 2016-12-15 2022-05-11 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備藥物中的用途
CA3067890A1 (en) * 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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DK3395354T3 (da) 2015-12-18 2024-06-03 Talengen Int Ltd Plasminogen til anvendelse i behandling af diabetisk nefropati
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11338022B2 (en) 2015-12-18 2022-05-24 Talengen International Limited Method for preventing and treating angiocardiopathy

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TW201822803A (zh) 2018-07-01
TWI763680B (zh) 2022-05-11
EP3556384B1 (en) 2024-04-10
DK3556383T5 (da) 2024-09-02
US20190314463A1 (en) 2019-10-17
EP3556392B1 (en) 2024-04-17
CN110121357A (zh) 2019-08-13
DK3556383T3 (da) 2024-05-13
US20190307861A1 (en) 2019-10-10
CA3047176A1 (en) 2018-06-21
US20190314464A1 (en) 2019-10-17
JP7554557B2 (ja) 2024-09-20
EP3556384A1 (en) 2019-10-23
EP3556383A4 (en) 2020-09-09
WO2018107703A1 (zh) 2018-06-21
CA3047176C (en) 2021-11-30
EP3556383A1 (en) 2019-10-23
JP2020502150A (ja) 2020-01-23
ES2981141T3 (es) 2024-10-07
JP2020502140A (ja) 2020-01-23
TW201822807A (zh) 2018-07-01
TW201822808A (zh) 2018-07-01
JP2020510628A (ja) 2020-04-09
JP2020502151A (ja) 2020-01-23
JP7554048B2 (ja) 2024-09-19
EP3556390A4 (en) 2020-09-09
TWI644682B (zh) 2018-12-21
CN110139667A (zh) 2019-08-16
EP3556383B1 (en) 2024-04-10
TWI738799B (zh) 2021-09-11
US20190314465A1 (en) 2019-10-17
TW201822801A (zh) 2018-07-01
CN110198732A (zh) 2019-09-03
TWI642442B (zh) 2018-12-01
WO2018107706A1 (zh) 2018-06-21
TWI763681B (zh) 2022-05-11
JP2022166026A (ja) 2022-11-01
EP3556392A4 (en) 2020-09-23
CA3047177A1 (en) 2018-06-21
EP3556390A1 (en) 2019-10-23
JP7175270B2 (ja) 2022-11-18
EP3556384A4 (en) 2020-09-23
US11311607B2 (en) 2022-04-26
EP3556390B1 (en) 2024-04-03
TWI669130B (zh) 2019-08-21
US11129880B2 (en) 2021-09-28
JP7171572B2 (ja) 2022-11-15
WO2018107705A1 (zh) 2018-06-21
EP3556392A1 (en) 2019-10-23
JP2022166028A (ja) 2022-11-01
WO2018107701A1 (zh) 2018-06-21
TW201822802A (zh) 2018-07-01
CA3047173A1 (en) 2018-06-21
CN110366426A (zh) 2019-10-22
TW201822804A (zh) 2018-07-01
WO2018107704A1 (zh) 2018-06-21
TW201822800A (zh) 2018-07-01
WO2018107702A1 (zh) 2018-06-21
WO2018107708A1 (zh) 2018-06-21

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Effective date: 20190614

FZDE Discontinued

Effective date: 20221018

FZDE Discontinued

Effective date: 20221018