CN110366426A - 一种促进胰岛素分泌的方法 - Google Patents

一种促进胰岛素分泌的方法 Download PDF

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Publication number
CN110366426A
CN110366426A CN201780078122.4A CN201780078122A CN110366426A CN 110366426 A CN110366426 A CN 110366426A CN 201780078122 A CN201780078122 A CN 201780078122A CN 110366426 A CN110366426 A CN 110366426A
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plasminogen
group
expression
subject
insulin
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李季男
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Talengen Institute of Life Sciences Co Ltd
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Talengen Institute of Life Sciences Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

一种促进胰岛素分泌的方法和药物，包括给药受试者有效量的纤溶酶原。

Description

PCT国内申请，说明书已公开。

Claims (56)

  1. PCT国内申请，权利要求书已公开。
CN201780078122.4A 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法 Pending CN110366426A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089065 WO2018107705A1 (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法

Publications (1)

Publication Number Publication Date
CN110366426A true CN110366426A (zh) 2019-10-22

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN201780078122.4A Pending CN110366426A (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法
CN201780078124.3A Pending CN110139667A (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法
CN201780078168.6A Pending CN110198732A (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201780078124.3A Pending CN110139667A (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法
CN201780078168.6A Pending CN110198732A (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Country Status (9)

Country Link
US (4) US20190307861A1 (zh)
EP (4) EP3556383B1 (zh)
JP (6) JP7175270B2 (zh)
CN (4) CN110366426A (zh)
CA (4) CA3047172A1 (zh)
DK (1) DK3556383T5 (zh)
ES (1) ES2981141T3 (zh)
TW (7) TWI763680B (zh)
WO (7) WO2018107702A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111411072A (zh) * 2020-03-09 2020-07-14 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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TWI624267B (zh) 2015-12-18 2018-05-21 Talengen Institute Of Life Sciences Co Ltd 纖溶酶原在製備預防或治療糖尿病性視網膜病變的藥劑上的用途及包括纖溶酶原用於預防或治療糖尿病性視網膜病變之藥劑
US11400142B2 (en) 2015-12-18 2022-08-02 Talengen International Limited Treatment of diabetic nerve injury comprising administering plasminogen
US11090372B2 (en) 2015-12-18 2021-08-17 Talengen International Limited Method of treating diabetic nephropathy comprising administering plasminogen
CN108778320A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗心血管病的新方法
WO2018107702A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种治疗糖尿病的新方法
EP3556382A4 (en) 2016-12-15 2020-12-09 Talengen International Limited METHOD OF PREVENTION AND TREATMENT OF SKIN FIBROSIS
US11938172B2 (en) 2017-06-19 2024-03-26 Talengen International Limited Method for regulating and controlling GLP-1/GLP-1R and drug

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN111411072A (zh) * 2020-03-09 2020-07-14 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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DK3556383T3 (da) 2024-05-13
EP3556390A4 (en) 2020-09-09
JP7554048B2 (ja) 2024-09-19
TW201822800A (zh) 2018-07-01
TWI763680B (zh) 2022-05-11
WO2018107703A1 (zh) 2018-06-21
US20190314463A1 (en) 2019-10-17
EP3556390A1 (en) 2019-10-23
US20190307861A1 (en) 2019-10-10
US11129880B2 (en) 2021-09-28
EP3556384B1 (en) 2024-04-10
TWI738799B (zh) 2021-09-11
JP2022166026A (ja) 2022-11-01
JP7175270B2 (ja) 2022-11-18
CN110139667A (zh) 2019-08-16
EP3556383B1 (en) 2024-04-10
JP2020502140A (ja) 2020-01-23
EP3556384A1 (en) 2019-10-23
JP2020502150A (ja) 2020-01-23
TW201822802A (zh) 2018-07-01
CA3047176A1 (en) 2018-06-21
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