TW201708251A - 用於免疫耐受誘導及免疫診斷之fviii胜肽 - Google Patents

用於免疫耐受誘導及免疫診斷之fviii胜肽 Download PDF

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Publication number
TW201708251A
TW201708251A TW105138248A TW105138248A TW201708251A TW 201708251 A TW201708251 A TW 201708251A TW 105138248 A TW105138248 A TW 105138248A TW 105138248 A TW105138248 A TW 105138248A TW 201708251 A TW201708251 A TW 201708251A
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Taiwan
Prior art keywords
peptide
fviii
prt
amino acid
homo sapiens
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TW105138248A
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English (en)
Chinese (zh)
Inventor
卡塔琳娜 諾拉 史坦尼茲
海登 寶拉 瑪莉亞 威爾漢密娜 凡
伯吉特 瑪莉亞 瑞伯特
漢斯 彼得 史瓦茲
哈穆 赫里基
Original Assignee
巴克斯歐塔公司
巴克斯歐塔有限公司
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Application filed by 巴克斯歐塔公司, 巴克斯歐塔有限公司 filed Critical 巴克斯歐塔公司
Publication of TW201708251A publication Critical patent/TW201708251A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56977HLA or MHC typing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
TW105138248A 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽 TW201708251A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40740210P 2010-10-27 2010-10-27
US201161467894P 2011-03-25 2011-03-25
US201161502476P 2011-06-29 2011-06-29

Publications (1)

Publication Number Publication Date
TW201708251A true TW201708251A (zh) 2017-03-01

Family

ID=45349271

Family Applications (3)

Application Number Title Priority Date Filing Date
TW106113613A TW201730205A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽
TW105138248A TW201708251A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽
TW100139078A TWI580430B (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽

Family Applications Before (1)

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TW106113613A TW201730205A (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽

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TW100139078A TWI580430B (zh) 2010-10-27 2011-10-27 用於免疫耐受誘導及免疫診斷之fviii胜肽

Country Status (20)

Country Link
US (3) US8969524B2 (enExample)
EP (2) EP2632479B1 (enExample)
JP (2) JP6122780B2 (enExample)
KR (2) KR102040867B1 (enExample)
CN (2) CN104926947A (enExample)
AR (1) AR083586A1 (enExample)
AU (2) AU2011319747C1 (enExample)
BR (1) BR112013010362A2 (enExample)
CA (1) CA2815239C (enExample)
DK (1) DK2632479T3 (enExample)
EA (1) EA034494B1 (enExample)
ES (2) ES2912455T3 (enExample)
HK (1) HK1215442A1 (enExample)
MX (1) MX347805B (enExample)
NZ (2) NZ703514A (enExample)
PL (2) PL2632479T3 (enExample)
PT (1) PT2632479T (enExample)
SG (2) SG10201600656WA (enExample)
TW (3) TW201730205A (enExample)
WO (1) WO2012058480A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063031A2 (en) 2004-12-06 2006-06-15 Haplomics Allelic variants of human factor viii
ES2626881T3 (es) * 2012-11-12 2017-07-26 Apitope International Nv Péptidos derivados del factor VIII para uso en el tratamiento de la hemofilia A
US10272163B2 (en) 2012-12-07 2019-04-30 The Regents Of The University Of California Factor VIII mutation repair and tolerance induction
EP2968499A4 (en) * 2013-03-15 2016-11-30 Haplomics Inc COMPOSITIONS AND METHODS FOR THE IMMUNO-TOLERANCE INDUCTION FOR FACTOR VIII SPATIAL THERAPIES IN PERSONS WITH HEMOPHILIA A
JP6488376B2 (ja) * 2014-06-12 2019-03-20 ユニヴァーシティ オブ ハワイUniversity Of Hawaii 免疫原性を低減するかまたは予防するためのヒト化コブラ毒因子を含む医薬組成物、薬剤および組み合わせ医薬
ES2869972T3 (es) * 2015-01-26 2021-10-26 Cellectis Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas
CN109804432B (zh) 2016-04-15 2023-07-14 武田药品工业株式会社 提供药代动力学药物给药方案的方法和设备
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL371278A1 (en) * 2002-04-18 2005-06-13 Merck Patent Gmbh Modified factor viii
US7485314B2 (en) * 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
EP2093569A3 (en) * 2004-05-21 2009-11-11 The Institute for Systems Biology Compositions and methods for quantification of serum glycoproteins
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
WO2007077217A2 (en) 2006-01-04 2007-07-12 Baxter International Inc. Oligopeptide-free cell culture media
GB0723712D0 (en) 2007-12-04 2008-01-16 Apitope Technology Bristol Ltd Peptides
US7673687B2 (en) 2007-12-05 2010-03-09 Halliburton Energy Services, Inc. Cement compositions comprising crystalline organic materials and methods of using same
DE202007017320U1 (de) 2007-12-07 2008-02-28 Dittmann, Ludwig Vorrichtung zur Raumbeduftung
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
WO2009099991A2 (en) 2008-01-31 2009-08-13 The Brigham And Women's Hospital, Inc. Treatment of cancer
BRPI0921429B1 (pt) 2008-11-07 2022-07-12 Takeda Pharmaceutical Company Limited Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável

Also Published As

Publication number Publication date
KR102040867B1 (ko) 2019-11-07
CN103298482A (zh) 2013-09-11
US20170267743A1 (en) 2017-09-21
DK2632479T3 (en) 2017-08-07
US8969524B2 (en) 2015-03-03
MX2013004753A (es) 2013-09-13
TW201730205A (zh) 2017-09-01
SG10201600656WA (en) 2016-02-26
EA201390617A1 (ru) 2013-10-30
CN104926947A (zh) 2015-09-23
AR083586A1 (es) 2013-03-06
TWI580430B (zh) 2017-05-01
AU2016202155B2 (en) 2018-02-01
KR20130128404A (ko) 2013-11-26
SG189914A1 (en) 2013-06-28
AU2016202155A1 (en) 2016-04-28
AU2011319747C1 (en) 2016-07-14
EP3260132A1 (en) 2017-12-27
CN103298482B (zh) 2015-08-19
ES2639039T3 (es) 2017-10-25
KR102222864B1 (ko) 2021-03-04
WO2012058480A1 (en) 2012-05-03
US9512198B2 (en) 2016-12-06
EP3260132B1 (en) 2022-02-09
ES2912455T3 (es) 2022-05-26
AU2011319747B2 (en) 2016-01-07
CA2815239A1 (en) 2012-05-03
MX347805B (es) 2017-05-15
JP2017095463A (ja) 2017-06-01
EP2632479A1 (en) 2013-09-04
NZ703514A (en) 2017-02-24
PL2632479T3 (pl) 2017-09-29
US20150203567A1 (en) 2015-07-23
JP2014505014A (ja) 2014-02-27
NZ609474A (en) 2015-06-26
PT2632479T (pt) 2017-07-24
EA034494B1 (ru) 2020-02-13
BR112013010362A2 (pt) 2016-08-02
HK1215442A1 (zh) 2016-08-26
EP2632479B1 (en) 2017-06-14
TW201231065A (en) 2012-08-01
JP6122780B2 (ja) 2017-04-26
PL3260132T3 (pl) 2022-08-08
CA2815239C (en) 2019-02-26
AU2011319747A1 (en) 2013-05-02
KR20190126189A (ko) 2019-11-08
US20120135019A1 (en) 2012-05-31

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