TW200920347A - Oral formulations for picoplatin - Google Patents

Info

Publication number

TW200920347A

TW200920347A TW097127053A TW97127053A TW200920347A TW 200920347 A TW200920347 A TW 200920347A TW 097127053 A TW097127053 A TW 097127053A TW 97127053 A TW97127053 A TW 97127053A TW 200920347 A TW200920347 A TW 200920347A

Authority

TW

Taiwan

Prior art keywords

cancer

picoplatin

preparation

formulation

oil

Prior art date

2007-07-16

Links

• Espacenet
• Global Dossier
• Discuss

• IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 title claims abstract description 192
• 229950005566 picoplatin Drugs 0.000 title claims abstract description 189
• 239000000203 mixture Substances 0.000 title claims abstract description 140
• 238000009472 formulation Methods 0.000 title claims abstract description 91
• 238000002360 preparation method Methods 0.000 claims abstract description 86
• 238000000034 method Methods 0.000 claims abstract description 74
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 63
• 239000003921 oil Substances 0.000 claims abstract description 62
• 239000000725 suspension Substances 0.000 claims abstract description 40
• 239000002246 antineoplastic agent Substances 0.000 claims abstract description 37
• 239000007962 solid dispersion Substances 0.000 claims abstract description 15
• 239000002245 particle Substances 0.000 claims description 79
• 206010028980 Neoplasm Diseases 0.000 claims description 62
• 235000019198 oils Nutrition 0.000 claims description 61
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 60
• 239000002904 solvent Substances 0.000 claims description 54
• 201000011510 cancer Diseases 0.000 claims description 47
• 229920001223 polyethylene glycol Polymers 0.000 claims description 44
• 239000002105 nanoparticle Substances 0.000 claims description 41
• 239000007787 solid Substances 0.000 claims description 41
• 239000002202 Polyethylene glycol Substances 0.000 claims description 38
• 239000006185 dispersion Substances 0.000 claims description 33
• 229910052697 platinum Inorganic materials 0.000 claims description 31
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 29
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 29
• 239000003112 inhibitor Substances 0.000 claims description 28
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• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 18
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• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 16
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• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 7
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