TW200904340A - Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same - Google Patents
Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same Download PDFInfo
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- TW200904340A TW200904340A TW097116524A TW97116524A TW200904340A TW 200904340 A TW200904340 A TW 200904340A TW 097116524 A TW097116524 A TW 097116524A TW 97116524 A TW97116524 A TW 97116524A TW 200904340 A TW200904340 A TW 200904340A
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- Taiwan
- Prior art keywords
- polysaccharide
- polysaccharides
- yeast
- gum
- glucomannan
- Prior art date
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- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 36
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Landscapes
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
200904340 九、發明說明: 【發明所屬之技術領域】 概言之,本發明係關於益生生物體領域,且更具體而 言,係關於已經益生生物體加工及處理之膳食補充品之組 合物及遞送方法。 【先前技術】 結合益生生物體闡述本發明先前技術並非欲限制其範 疇。益生生物體可對健康具有若干積極作用。通常,吾人 提供益生生物體以使其進入並佔據部分消化道。益生菌可 與先别已疋植於消化道中之本地生物體相互競爭。該等本 地生物體可藉由其他微生物抑制定植且在某些情況下可能 對健康助消化菌群之形成有害。目前有許多可攝入以期形 成期望的有益腸菌群的益生生物體。然而,可攝入以期與 本地生物體競爭之盈生菌培養物的有效性通常受限於生物 體能否到達目的位置、競爭得過本地生物體、建立穩定佔 據及與既有生物體競爭營養素。不期望之助消化生物體的 問題係其通常會逐漸對抗生素產生抵抗、在腸黏膜中大量 形成、具有適應本地環境之良機、並可有效競爭營養素且 不會被轉運出消化道。 一項意欲陳述益生菌佔據問題之該發明教示於授予 Schmitt等人之關於製備益生菌酸㈣食品之粉末的美國專 利案第7,172’777號。簡而言之,教示—種用於製備 益生菌酸乳酪食品的粉末,該粉末含有益生菌培養物盥預 設比例之活益生乳酸菌與強化腸内重吸收過程之產熱脂解 130939.doc 200904340 吸收增強劑(具體而言係胡椒提取物),以及達成腸道毛細 管擴張之毛細管擴張劑(具體而言係煙鹼酸)。 又一發明教示於授予Watson等人之美國專利案第 6,468,525號,其係關於包含有益益生菌微生物群落混合物 的用作食品添加劑之益生菌調配物及用於重建人體腸道内 有益細菌之物質,該混合物包含嗜酸乳桿菌(lactobacillus acidophilus)、兩岐雙岐桿菌(bifid〇bacterium bifidum)、唾 液乳桿菌(lactobacillus salivarius)、嬰兒雙岐桿菌 (bifidobacterium infantis)、及長雙歧桿菌(bifid〇bacterium longum)、寡聚果糖、l-麵胺醯胺、及N-乙醯葡萄糖胺。 又一發明教示於授予perry之美國專利案第6,2〇3,797 號,其係關於用於減輕與刺激性腸症候群相關之症狀的膳 艮補充α口及作為益生產之使用方法。所教示之膳食補充品 係一種益生菌且用於減輕刺激性腸症候群症狀,其包含經 冷凍乾燥的蘆薈、寡聚果糖、及大麗花菊粉汁混合物且較 佳地包含維他命Β6(吡哆素)、錳及^麵胺醯胺。尤其用於 減輕刺激性腸症候群症狀之其他替代實施例在基礎配方中 包含鳳梨蛋白酶與木瓜蛋白酶。且為達成特定益生菌功 能,可向該基本配方添加以下友好細菌:保加利亞乳桿菌 (―⑽7/w ⑽)、嗜酸乳桿菌、植物乳桿菌 、及兩岐雙岐桿菌。 授予Brown等人之美國專利案第6,〇6〇,〇5〇號教示包含於 食品中以增強其營養價值之益生菌組合物。該組合物包含 一或多種益生微生物(例如雙歧桿菌)及用以向大腸或胃腸 130939.doc 200904340 道之其他區域轉運該等微生物之載劑。該载劑為改性或未 改性抗性澱粉(尤其係高直鏈澱粉),其作為大腸或胃腸道 其他區域之微生物的生長或維持培養基。 美國專利申請案第20070059296號教示一種含抗酸性腸 溶包膜之益生菌組合物,其包含15_2〇重量%之奶粉、25_ 30重量%之玉米澱粉、8·15重量%之改性澱粉(膠囊)、Μη 重量 %之乙基纖維素 、 5_15 重量 %之細 菌肉湯 、及ι〇_ΐ5 重量。/。之滑石粉。將該益生菌組合物裝入微膠囊以形成複 數個包被抗酸腸溶包膜的微膠囊,以改進抗腸酸性、益生 菌存活率、抗菌特性、穩、定性、抗濕特性、及益生菌組合 物之流動性以防止在濕潤環境中凝結以及用作施用至家畜 飼料之添加劑.。 【發明内容】 儘管吾人多次嘗試經多種遞送方法及以多種數量來遞送 多種形式之益生生物體來以此再產生助消化菌_,但仍需 以生物可利用營養素對生物體進行營養補充。本發明人意 j到在助消化菌群不發生改變時及/或在重建有益助消化 菌,過私中,仍需要該等共生微生物自宿主食用食品產生 的營養素。共生消化道微生物可為宿主提供大量有益功 能’包括:發酵未用能量受f ;激活免疫系統,·防止非共 生或有害物種生長;為宿主生產維他命與營養素前體(包 括生物素及維他命K),及產生某些荷爾蒙(h__)或荷 爾蒙前體。 一般而言,本發明係關於使用微生物物種來將天然多醣 130939.doc 200904340 地里成八有勝食補充品或食品功效之有用食品的新 及組合物。本發明包括在生物反應器系統中組、夕法 與經選擇益生菌並使該等細菌在身體外處理該等多糖夕7 後使用生物反應器產物製備食品或膳食補充品。=本發f 之另:實施例中,組合經選擇天然多聽與經選擇非病原: (益生菌)微生物物種之劑型以提供營養補充且同^ 需前體益生菌營養素及共生生物體。藉由同時向人二腸 道投與該等物質,非病原性微生物物種將多糖處理成发他 有益產物之過程可在人類胃腸道區域内完成。 〃、 吾人預期經選擇多醣組份之該微生物處理過程所產生之 新賴產物對人類健康之有利影響包括:⑴藉由與黏膜相關 淋巴網狀内皮細胞組織(M A L τ)相互作用改進胃腸道與系 統免疫功能;(2)藉由以下控制體重並減少肥_ :⑷改進 胃腸道消化及營養吸收功效;(b)減少人類胃腸道中不期望 之U生物物種,及⑷導入之益生微生物及多聽產物與多種 控制因子(亦即荷爾蒙受體)在人類胃腸道内相互作用;及/ 或(3)改進血脂參數’例如降低膽固醇及降低甘油三酿水 平0 在心樣中本發明係關於一種勝食補充品,其包含由 -或多種天然多與益生菌在生物反應器系統中經先前培 月所生產之補充品’其中該等細菌對該等多醣進行處理且 所侍之經處理多醣可提供於營養補充品中。在一實施例 中’自生物反應器所獲之經處理多醣適宜用於食品或膳食 補充扣’例如適宜用於單次劑型中。本發明所用之多醣可 130939.doc 200904340 包含以下之至φ _叙._ ·葡甘露聚糖、蘆薈葡甘露聚糖、魔 于匍甘露聚糖、半聋丨廿带取 礼甘路聚糖、阿拉伯半乳聚糖、落葉松 阿拉伯半乳聚糖、海萍客醃、山该分5 + '栗夕醣石溱依聚糖、真菌多醣、真 菌葡甘露聚糖、黃蓍膠、印度膠、黃原膠、瓜爾豆膠、及 金合歡樹膠。在—實施例中,多醣及存活的微生物細胞以 單次劑型分別提供。在另—實施例中,多酿及存活的微生 物、.、田胞在生物反應Ig中培育。多醣及存活的微生物細胞亦 I以持續釋放形式提供。多醣之實例包括雜多_、同多酷 或二者皆有。在膳食補充品之一實例中,自微生物細胞分 離多醣並將該等經分離多·載人選自粉末、膠囊、軟膝 囊、錠劑、發泡錠、液體劑或黏性劑之劑型中。 在另一態樣中,本發明係關於包含一或多種天然多醣及 選自以下之至少一種存活微生物細胞之益生菌食品或膳食 補充品調配物:乳桿菌、乳球菌 (Laciococcw)、鏈球菌、腸球菌
(五《以、明串珠菌仏⑼⑺㈣“%)、醋桿菌 、念珠菌(c⑽心心)、克魯弗氏酵母 、酵母菌(知、圓酵母菌 (r〇rw/a)、有孢圓酵母菌、德巴利酵母菌 、接合糖酵母菌、擬 择蛰(Bacterioides)、芽孢桿菌(如以//似)、雙歧桿菌 (价/zWokcieWww)、真細菌(五w^eierz,M/w)、消化鏈球菌 、瘤胃球菌(及wwzCOCCM〇及片球菌 。多醣可為以下之至少一種:葡甘露聚糖、 130939.doc 200904340 蘆薈葡甘露聚糖、魔芋葡甘露聚糖、半乳甘露聚糖、阿拉 伯半乳聚糖、落葉松阿拉伯半乳聚糖、海藻多冑、岩藻依 聚糖、真菌多醣、真菌葡甘露聚糖、黃蓍膠、印度膠、黃 原膠、瓜爾豆膠、及金合歡樹膠。在一實施例巾,多畴: 存活的微生物細胞以單次劑型分別提供。在另一實施例 中,多酷及存活的微生物細胞在生物反應器中培育。在又 -實施例中,多醣及存活的微生物細胞以持續釋放形式提 供。 在另一態樣中,本發明係關於包含藉由非病原性、益生 菌微生物物種在生物反應器中處理之經選擇天然多醣提取 物的膳食補充品。在又一態樣中,本發明包括製備膳食補 充品之方法,其係藉由在可刺激細菌處理天然多醣之條件 下於生物反應器系統中將一或多種天然多醣與益生菌相混 合以製備經處理多醣來達成;及在至少一部分天然多醣已 經細菌處理後來製備膳食補充品。在一實施例中,細菌處 理多醣並將所得經處理多醣製備成單一劑量營養補充品。 在一實施例中,該方法進一步包括自天然多醣及細菌中分 離經處理多醣之步驟;及製備包含該等經處理多醣之劑 型。在另一實施例中,該方法進一步包含製備包含該等經 處理多醣、天然多醣及細菌之劑型的步驟。在另一實施例 中,該方法進一步包括將該等經處理多醣載入選自粉末、 膠囊、軟膠囊、錠劑、發泡錠、液體劑或黏性劑之劑型 中。在另一實施例中,將該等經處理多醣自細菌中分離, 並將該等經處理多醣載入選自粉末、膠囊、軟膠囊、錠 130939.doc 200904340 劑、發泡錠、液體劑或黏性劑之劑型中。 在另一態樣中,本發明係關於包含在生物反應器或發酵 槽系統中與益生菌-起培育的經處理蘆薈内葉膠的膳食補 充品或食品,其中該等細菌將蘆薈内葉膠處理成生物可利 用產物。在一實施例中,該等益生菌包括選自以下之至少 -種細菌:乳桿菌、乳球菌、鏈球菌、腸球菌、明串珠 菌、醋桿菌 '念珠菌、克魯弗氏酵母、酵母菌、圓酵母 菌、有孢圓酵母@、德巴利酵母菌、接合糖酵母菌、擬桿 菌、芽孢桿®、雙歧桿n、真細菌、消化鏈球菌、瘤胃球 ii及片球菌或其組合。 【實施方式】 當下文詳細討論本發明多個實施例之製備及使用時,應 瞭解本發明可提供許多可在多種具體背景下實施之實用發 明概念。本文所述之具體實施例僅係製備及使用本發明之 具體方法的例示性說明且並不界定本發明之範疇。 為便於理解本發明,下文將定義若干術語。本文所定義 之術語具有熟習與本發明相關領域之—般技術者通常理解 之含義。諸如"一(a' an)"及"該(等)”等術語非欲指單數實 體,而係包含可使用具體實例說明之一般類別。本文術二 用以闡述本發明之具體實施例,而除請求項所概述之外, 其用法並不界定本發明。 本文所用之術語"營養有效量,,用以定義可在哺乳動物中 提供有益營養效果或應答之量。舉例而言,由於對腾食補 充品之營養應答在各種哺乳動物之間不同,因此應理解含 130939.doc 200904340 有經選擇益生菌之天然多酷的營養有效量亦將各自不同。 本發明包括結合未激活益生菌的已經來自益生菌之益生菌 分離物(至少部分分離自益生菌)處理的天然多醣及:然多 骑與益生菌相結合等兩種形式。 夕 熟習此項技術者應瞭解特定個體將受益於已經益生菌預 處理之天然多醣的一或多種組合調配物(例如,彼等具有 正常助消化菌群者,彼等不需額外補充益生菌者及甚:彼 等不需益生菌者)。類似地,已知缺少具有經選擇益生菌 之天然多醣可影響生理及細胞功能。 本文所揭示具有經選擇益生菌之天然多㈣營養有效量 可發揮以下功效:保持及/或提高(例如)力求維持或增加里 該等營養補充品飲食之人類的飲食中該等關鍵營養素之水 平。因此,一種哺乳動物可能需要以定義量呈現之經選擇 益生菌的特定量天然多’而另—哺乳動物可能需要以不 同疋義量呈現之特定量維他命及礦物質。
本文所用術語,,天然多醣”、"糖營養性,,或,,糖營養素”意 指可自天然來源獲得且為各類交流及信號分子之生化合成 所必需之複合碳水化合物、多酶、寡畴、雙醣或單醋:里 可游離於間質細胞液令,可在細胞與細胞交流中具有活性 (亦即細胞因子、生長因子等),或可構成包含高度特異性 細胞膜分子活性位點(亦即受體位點、離子轉運通道、抗 原識別、及諸如此類)之分子構型。 在自然界中可發現本發明之 私a之天然多醣為早醣、寡醣及/ 或多醣。因此,本發明之組合物 口初了含有呈早體、寡聚體及/ 130939.doc 200904340 或多聚體形式之糖類。為瞭解天然多醣之所有已知天然來 源及其用途’請參考美國專利案第US2003072770號,相關 糖類及糖類來源以引用的方式併入本文中。 在某些實施例_,可製備本發明之活性劑以呈改良或延 遲釋放形式遞送。舉例而言,當藥劑對酸敏感時,該藥劑 可以腸溶包膜遞送以在釋放前到達腸道。本文所用術語 ”改良釋放”、,,延長釋放”及”控卿放"描述經延長時間段 (本文定義為介於約60分鐘至約2、4、6、8小時或更長時 間)對使用本發明調配形式之營養有效量的營養素實施遞 送的-或多種釋放特性。改良釋放亦可在功能上定義為約 〇刀名里至約2、4、6、或甚至8小時後營養素釋放超過 啊。該釋放亦可藉由向使用者提供天然維他命或天然礦 :質來評估而不論是否吸收,乃因某些活性成份不可能為 勿所吸收。如本文所揭示’熟習此項技術者可容易地設 ^多種改良釋放劑型以達成向小腸及大腸、僅向小腸、或 =向大腸遞送’此端視包被物質之選擇及/或包被厚度而 可對長鏈多酷進行改自夕眘, 仃改艮之實例包括(例如)改變長鏈客脑 中糖類類型或組成、化學修飾 夕醣 =乙㈣卜水解長鏈多醣、改變長鏈㈣之大小、Ϊ «更長的長鏈多醣、選擇較短及 ^ 及藉由(例如)電穿孔、FPLC、:::多醣之組合、 :層析法、沈殿及諸如此類分離長鏈多醣、。=備=排 延長釋放調配物,從而可在下腸道中與沒有改良 130939.doc 200904340 時達成釋放之位置相比某一可大致預測之更遠端位置達成 釋放。 本文所用術語”碳水化合物"用以與術語"糖"、,,多醣”' "寡醣"及"食糖"交互使用’料術語之定義為彼等熟習碳 水化合物化學之技術者所熟知。儘管本發明之組合物意欲 包括至少兩種或更多種關鍵糖類,但應注意該等糖類可呈 單醣、寡醣及/或多醣形式,例如,吾人認為含有黃蓍膠 與瓜爾豆膝之組合物含有半乳糖酿酸、㈣酸、甘露糖及 半乳糖。因此,藉由控制給定膳食補充品中特定膠類之 畺’吾人可控制膳食補充品中各自糖類之量。 本文所用術語,,分離的”意指已進行分餾以移除多種其他 組份並實質上保留其所表現之生物活性的一種有機分子或 一組類似分子。在使用術語"實質純淨"時,該名稱意指一 組合物,其中該組合物之活性形式營養素構成該組合物中 總分子數之約 10%、20%、30%、40%、5〇%、6〇%、 70%、80%、9G%、95%或更#。在某些情形下,活性形式 呂養素不旎自其正常細胞環境中成功移除而不影響其活 性。事實上,本發明利用益生微生物在生物反應器中對多 醣之天然處理來遞送最高質量及數量的具有活性的營養化 合物。然而,在某些情形下,需在處理或”分離,I水平、化 合物之有效性與總體成本及對環境之影響之間達成平衡。 熟習此項技術者將瞭解能將化合物有效性最大化並同時保 羞袞i兄。在工廠方面(例如本地工廠),亦必須與當地文化 及社區維持平衡以將工廠產品(包括經分離的用於本發明 130939.doc -14- 200904340 之營養化合物)之影響最小化。 使用本發明用以製備天然多醣與益生菌之有用劑型的技 術及組合物闡述於以下參考文獻之一或多篇中:Ansel, Introduction to Pharmaceutical Dosage Forms,第 2 版 (1976) ; Remington's Pharmaceutical Sciences,第 17 版 (Mack 出版公司,Easton, Pa·, 1985) ; Advances in Pharmaceutical Sciences(David Ganderton, Trevor Jones, 編輯 ’ 1992) ; Advances in Pharmaceutical Sciences,第7 卷 ’ (David Ganderton, Trevor Jones, James McGinity > 編 輯 ’ 1995) ; Aqueous Polymeric Coatings for
Pharmaceutical Dosage Forms (Drugs and the Pharmaceutical Sciences,第 36輯(James McGinity 編輯, 1989) ; Pharmaceutical Particulate Carriers: Therapeutic Applications: Drugs and the Pharmaceutical Sciences » 第 61 卷(Alain Rolland 編輯,1993) ; Drug Delivery to the Gastrointestinal Tract (Ellis Horwood Books in the Biological Sciences. Series in Pharmaceutical Technology ; J. G. Hardy, S. S. Davis,Clive G. Wilson,編輯);Modern
Pharmaceutics Drugs and the Pharmaceutical Sciences,第 40 卷(Gilbert S. Banker,Christopher T. Rhodes,編輯),及 諸如此類,相關部分以引用的方式併入本文中。 舉例而言,本發明之組合物可包含於錠劑中。錠劑可含 有(例如)適宜結合劑、潤滑劑、崩解劑、著色劑、矯味 劑、促流動劑、黏著劑、咀嚼劑及/或熔融劑。舉例而 130939.doc 15 200904340 言,可以錠劑、軟膠囊、膜衣錠或膠囊等單位劑量形式經 口投與’活性藥物成份可與無毒的醫藥上可接受的情性載 劑(乳糖、明膠、瓊脂、澱粉、蔗搪、葡萄糖、甲基纖維 素、硬脂酸鎂、磷酸二鈣、硫酸鈣、甘露糖醇、山梨醇、 其混合物、及諸如此類)相結合。用於本發明之適宜結合 劑包括澱粉、明膠、天然食糖(例如葡萄糖或万-乳糖)、玉 米甜味劑、天然及合成膠(例如阿拉伯膠、磺蓍膠或藻酸 鈉)、羧甲基纖維素、聚乙二醇、蠟及諸如此類。用於本 發明之潤滑劑可包括:油酸鈉、硬脂酸鈉、硬脂酸鎂、苯 曱酸鈉、乙酸鈉、氣化鈉、磷酸二鈣'及其混合物、及諸 如此類。崩解劑可包括:澱粉、甲基纖維素、瓊脂、膨潤 土、!原膠、其混合物及諸如此類。 包含於本發明腾食補充品中之多醣、寡醣、雙醣或單醣 可自多種天然及合成來源獲得,例如灌木、樹木、植物、 酵母、真®、a菌、踢、樹脂、澱粉及纖維切生物及天 =黏蛋白源。用於本發明之某些天絲源多餹之非限制性 實例包括:⑷含有阿拉伯膠、刺梧桐樹膠、磺蓍膠、或印 ?樹膠之灌木或樹木分泌物;(b)海生膠,包括瓊脂、藻 膠、或角叉菜膠;(c)種子膠’包括瓜爾豆、刺槐豆、或車 前草;⑷含有果膠或乙醯化多聚甘露糖之植物提取物; (:)澱粉及纖維素衍生物’例如羧甲基纖維素、乙基纖維 基甲基纖維素、甲基纖維素、氧化型纖維素;及 之组=糖之试生物膠、及黃原膠。然、而,應瞭解本發明 、、口物不欲党各自糖類所獲取之來源所限制。 130939.doc 200904340 本文交互使用之術語"植物來源"、”植物粉末"、”植物提 取物及草藥提取物"意指可在植物組織中產生並可使用 本發明盈生菌微生物處理之天然來源的多醣、寡醣、雙醣 或早醣。組成本發明一部分之天然來源多醣、寡醣、雙醣 或單聽的天然來源通常係自天然狀態分離之至少一部分植 株’例如’藉由移除水(例如提取汁液及/或果肉)、採用化 干機械、熱方法提取一或多種在某種程度上具有有益於 健康或治療活性的組份’使用極性、非極性、擴物質、石 油或其他洛劑藉由尺寸或其他方式分離該等組份。自植物 分離活性劑端視活性劑性質而變,例士。,水溶性、水不溶 性、可與水混溶及諸如此類,以及對分解的敏感性(例 由於,、、、 PH、氧、光等而變性)。植物提取物亦包括 1脫水的植物物質’其中大量液體被移除以濃縮植物或草 藥中生物可利用固Μ。大部分草藥劑可能有毒,尤其係濃 縮時仁田以更傳統方式(於茶中及膏藥中作為"用於治療 疾病及促進良好健康之民間醫藥,,)使科其—般而言較安 全。 生物物種,其包括乳 係胃腸(GI)道微生物 品或膳食補充品而介 益生菌係活的非病原性及非產毒微 桿菌種、雙歧桿菌種及酵母,其可能 群落之天然成份或可經由補充特定食 入胃腸道微生物群落種群中。益生菌藉由改進腸微生物群 落平衡而有益地影響宿主生物體攝食。若干再新研究表明 某些活微生物可能具有免疫調節與抗癌作用以及1他 益處。胃腸道中某些微生物群落亦可藉由處理(例如發酵) 130939.doc 17 200904340 而完成特定食品之消化。腸微生物群落對免疫系統成熟、 形成正常腸形態、以及為維持慢性及免疫平衡性炎症應答 而5很重要。微生物群落可加強腸黏膜屏障功能,防止病 原體附著及過敏性物質進入。目前對目標益生菌有許多活 性科學研究,該等研究使用經選擇具有特定增強健康作用 之良好定性的細菌。目前,在Physician,s㈣純代㈣ (PDR)中,認為雙歧桿菌及乳桿菌之多個種、以及乳酸乳 球菌、嗜熱鏈球菌、原腸球菌(細㈣⑽⑽和⑽叫及總 氏酵母菌少ό⑽/ar&〇為益生菌。 7粉末。經益生菌處理之多料以粉末形式提供。該粉末 心式亦可包括本文所揭示之益生菌或其部分。通常,該粉 末形式亦可包含一或多種可改善外觀、感覺及甚至有助於 保存粉末的載劑、賦形劑、潤濕劑、流動劑、調味劑、著 色劑及諸如此類。 膠囊勝囊可藉由向標準的兩片式硬質明膠膠囊中各填 充1至1000毫克經益生菌處理之多醣而製備。該等膠囊亦 可以賦形劑、载劑及諸如此類填充,例如,0 5_150毫克乳 糖、0.1-500毫克纖維素及o.uo毫克硬脂酸鎂。該等膠囊 亦可包含本文所揭示之益生菌。 軟質明膠膠囊。將經益生菌處理之多膽混合物溶解於易 消化油(例如豆油' 棉籽油、或撖欖油、及諸如此類)中。 使用正置換泵將經益生菌處理之多注射進明膠中以形成 3有(例如)1 00_500毫克經益生菌處理多聽之軟質明膠膠 囊。洗滌並乾燥該等軟凝膠膠囊。該等軟凝膠膠囊亦可包 130939.doc -18- 200904340 含本文所揭示之益生菌。 錠劑。藉由習用程序製備錠劑以使劑量單元含有1〇〇_ 5〇〇毫克經益生菌處理之多醣、〇 2毫克膠狀二氧化矽、$ 毫克硬脂酸鎂、50-275毫克微晶纖維素、u毫克澱粉及 98.8毫克乳糖。可塗敷適當塗層以增加適口性或延緩吸 收。該等錠劑亦可包含本文所揭示之益生菌。 為提供適宜量(例如)檸檬酸單納與碳酸氫鈉之發泡錠, 將二者混合在一起且隨後在無水條件下軋輥壓製形成薄 片,隨後將薄片粉碎以得到顆粒。隨後將該等顆粒與經益 生菌處理之多醣、藥物及/或其鹽、習用成珠劑或填充劑 且視情況與甜味劑、調味劑及潤滑劑相結合。發泡錠亦可 包含本文所揭示之益生菌。
懸浮液。製備水性懸浮液以用於經口投與,以使每5 W 含100 mg微細的經益生菌處理之多聽、2〇〇 mg羧甲基纖維 素鈉、5 mg苯甲酸鈉、u g山梨醇溶液⑴s p )、及 ml香草醛。該懸浮液亦可包含本文所揭示之益生菌。 對於小旋劑’則將經益生菌處理之多_製成硬度範圍 為6-12 Kp。最終錠劑硬度受製備顆粒時所用之線性滾動 壓製力的影響,該壓製力受(例如)碳酸氫單納與碳酸氯納 之粒徑影響。對於更小粒徑,可使用約ΐ5_2〇 κν/⑽之線 性壓製力。 對於本發明可與之組合的黏性可食用品,參見(例如)頒 予Yang等人之美國專利案第5,92M64號之教示,其相關部 分以引用的方式併入本文中。簡而言之,教示一種黏性可 130939.doc -19- 200904340 食用遞送系統’其中將本發明倂入黏性可食用遞送系统 中’其中包含經益生菌處理之多畴與甘油化明膠基質之混 合物’該甘油化明膠基質係藉由將明膠與甘油之水性溶液 加熱足夠溫度及時間以移除起始水性溶液之若干水分而製 備。本文所教不之經益生菌處理多醣可自剪切成形基質載 劑遞送。對於提供"黏性-致性"之以植物為主的調配物, 本發明可使用教示於(例如)頒予Grazela等人之美國專利案 第6,58M32號之組合物及方法,相關部分以引料方式併 入本文中。簡而…使用結冷膠與角又菜膠而不含明膠 的黏性甜點可在不含明膠的黏性甜點中提供堅固且富有彈 性的明膠樣結構。該黏性可食用品亦可包含本文所揭示之 益生菌。 吾人亦已知特定種胃腸道微生物料(例如多形擬桿菌) 所產生之酵素可有助於消化人類產生之正常消化酵#法 降解的物質’例如β-鍵結植物纖維。多形擬桿菌可藉由產 生β-葡糖基水解酶酵素而明顯達成此功能。該等酵素及其 立物貝之產生似乎係由暴露於特定多醣受質所誘導。應注 意據報導某些該等酵素係細胞外分泌的。某些新研究亦揭 示多形擬桿g具有在内臟中誘導宿主分子岩藻糖基化、刺 激血管發生及誘導先天免疫應答之功能。最近已表明另一 種擬桿菌(細,月危弱擬桿菌咖㈣如介邮叫 可產生-種細菌多酶(PSA)’該細菌多醣可指導小鼠發育 中的免疫系統細胞及物理成熟。由於擬桿菌種係—種最早 伯據且數量最多之内臟微生物群落,因此此極顯[星體 130939.doc •20· 200904340 而言,脆弱擬桿菌係—種普遍存在且重要的革蘭氏陰性厭 氧菌,其佔據哺乳動物下胃腸道。 細菌種(例如多形擬桿菌)釋放之細胞外β-葡糖基水解酶 酵素可將β·鍵結多酿降格成更小的㈣、寡醣、及簡單單 醣與雙酷。事實上’已證實多形擬桿菌具有在使用落葉松 阿拉伯半乳聚糖之連續培養基(其含有短鏈、中鏈及長鏈 多醣)中生長之能力。該等酵素消化產物可供給其他微生 物吸收及利用或為人類經由腸吸收。雖然吾人已廣泛研究 某些微生物物種(例如腸桿菌及產乳酸細菌)在細胞内之多 醋發酵,然而細菌(例如人類胃腸道之多形擬桿菌)之細胞 外酵素/肖化之實際生物學意義顯然尚未得到廣泛探索。 乳酸菌、腸球菌具有生態學多能性並能耐受較寬範圍的 溫度及pH條件《其佔據人類小腸及大腸中。兩種最能競爭 本研究中所有三個IP的細菌··糞腸球菌(五介ecfl/⑷及屏、腸 球菌(£· 係較受歡迎的益生菌。已有補充人類益 生菌研究之文獻報導,此二種細菌皆可刺激免疫系統。亦 顯示屎腸球菌可降低血清膽固醇並降低與炎症應答相關之 細胞受體的表現。 赶菌素係可刺激特定胃腸道微生物生長或活性的食品成 份。市售益菌素通常係不能消化的植物來源多醣,該等多 醋可選擇性地藉由某些有益乳酸細菌(例如雙歧桿菌及乳 才干囷種)Ik由厭氧1發酵代謝利用。若干通常使用之益菌素 包括菊粉、寡聚果糖(FOS)、及耶路撒冷洋薊(Jerusalem artichoke) ° 130939.doc 21 200904340 實例1. 生長。 選擇益生菌培養物 以促進在經選擇多醣受質中 之 存在於人類胃腸道之不同細_屬及株具有制不同多 醋受質之能力。舉例…在-項研究中,22個不同種之 雙歧桿菌、消化鏈球菌、乳桿菌、瘤胃球菌、糞球菌 (C_〇⑽⑽)、真細8、及梭桿_ W伽請)的154 株據調查具有發酵21種不同複合碳水化合物之能力。普通 食品多㈣粉(直鏈殿粉)與支鏈澱粉可為大部分細菌株發 酵在又調查的22種中有7種中至少若干株可利用直鍵殺 ;或支鏈歲柘。其他多醣(例如D-半乳糖胺、葡聚糖、 &梧桐樹膠、;5·藻依聚糖、藻酸鹽、角叉菜膠、硫酸軟骨 素月貝酉夂鹽、肝素、類卵黏蛋白、及牛下顆黏蛋白)不 能為任何受試g株發酵。調查中所包括之其他多酿(葡萄 糖胺、岩藻醣、木聚糖、落葉松阿拉伯半乳聚糖、瓜爾豆 膠刺槐旦膠、阿拉伯樹膠、印度膠、黃着勝、果膠、聚 半&糖搭鹽 '及昆布多醋)可為特定細菌株而非其他細 菌株選擇性發酵。該研究表明自人類胃腸道選擇細菌株經 由發酵來選擇性處理經選擇多醣係可能的。 經培育食品(例如經發酵蔬菜、酸乳酪、酸奶、衣梅爾 (ymer)、g#礼及拉班⑽吨使用多種微生物來產生人類可 食用的食品。 大量細菌及酵母種屬可安全地用於生產該等食品。安全 用於^類食品具有較長歷史之該等微生物係極佳之供篩選 候選菌’目為其具有將經純化長鏈多醣化合物處理成更小 130939.doc -22- 200904340 生物活性化合物(例如更短多醣、寡酿 力。可將該處理設計成在活體内進行,㈣及早醣)之能 種該等微生物與天然多膽結合成可將二組份同二:;多 二了其他動物之形式。在該第-實例中,微生物 ,之處理將在經過胃腸道轉運時進行。該微生物: 夕醣可在機械發酵裝置中於受控物理條件下(亦即營養 素、溫度、氫離子濃度、氧化/還原電勢、氧可用率、水 活度、鹽濃度等)結合並將其培育直至產生期望最終產物 (亦即可接夂比率之更短多醣 '寡醣、雙醣、及單醣)。 酸牛乳酒糟係多種細菌及酵母穩定的混合培養物,其中 發現之典型微生物包括: 嗜酸乳桿菌 短乳桿菌(Lb. brevis:» 乾酷乳桿囷(Lb. casei) 乳酸乳桿菌(Lb. lactis)
植物乳桿菌 虽J 乾路乳桿 _ (Lb, paracasei) 纖維雙酸乳桿菌(L. ceii〇bi〇sus) 德爾布乳桿菌(Lb. delbrueckii) 食果糖乳桿菌(Lb. fructivorans) 每 士1 乳桿菌(Lb. helveticus) 希氏乳桿菌(Lb. hilgardii) 開菲爾乳桿菌(Lb. kefiri) 馬乳酒乳桿菌(Lb. kefiranofaciens) 130939.doc -23- 200904340 高加索酸奶粒乳桿菌(Lb. kefirgranum) 副開菲爾乳桿菌(Lb. parakefir) 乳酸乳球菌 唾液鍵球菌(Streptococcus salivarius) 嘴熱鏈球菌(S. thermophilis) 乳鏈球菌(S. lactis) 而f 久腸球菌(Enterococcus durans) 檸膠明串珠菌(Leuconostoc cremoris) 腸膜明串珠菌(Leuc. mesenteroides) 醋酸桿菌(Acetobacter aceti) 惡臭醋桿菌(A. ransens) 開菲假絲酵母(Candida kefir) 假熱帶念珠菌(C. pseudotropicalis) 惡臭假絲酵母(C. rancens) C. tenuis 乳酸克魯維酵母(Kluveromyces lactis) 1' ' i 馬克斯克魯維酵母(K. marxianus) 保加利亞克魯.維酵母(K. hulgaricus) 脆弱克魯維酵母(K. fragilis) 開菲酵母(Saccharomyces kefir) 釀酒酵母(S. cervisiae) 乳酸酵母(S. lactis) 卡爾斯伯酵母(S. carlsbergensis) 單抱酵母(S. unisporus) -24- 130939.doc 200904340 魯氏酵母(S. rouxii) 開菲圓酵母 德爾布有孢圓酵母菌(Torulaspora delbrueckii) 德巴利酵母菌 魯氏接合糖酵母菌(Zygosaccharomyces rouxii) 用於蔬菜及奶品發酵之典型細菌包括: 嗜酸乳桿菌 保加利亞乳桿菌 植物乳桿菌 乳酸乳桿菌 德爾布乳桿菌 賴氏乳桿菌(L. leichmannii) 唾液乳桿菌 L. caret 戍乙酸乳桿菌(L. pentoaceticus) 短乳桿菌 布氏乳桿菌(L. buchneri) 纖維雙醣乳桿菌 融合乳桿菌(L. Confusus) ' 嗜糞乳桿菌(L. coprophilus) 發酵乳桿菌(L. fermentatum) 加裏佛尼亞乳桿菌(L. sanfrancisco) 嗜熱乳桿菌(L. thermophilus) 巴伐利亞乳桿菌(L. bavaricus) 130939.doc -25- 200904340 乾酪乳桿菌 棒狀乳桿菌(L. coryniformis) 弯曲乳桿菌(L. curvatus) 植物乳桿菌 清酒乳桿菌(L. sake) 葡聚糖明串珠菌(Leuconostoc dextranicum) 腸膜明串珠菌 類腸膜明串珠菌(Leu. paramesenteroides) f 蜜蜂屎腸球菌(Enterococcus faecium) 糞勝球 _ (Enterococcus faecalis) 乳酸片球菌(pediococcus acidilactici) 有害片球菌(Pediococcus damnosus) 戍糖片球 _ (Pediococcus pentocacus) 實例2.促進益生菌生物體生長及利用多醣之額外試劑 除了多醣外’可能有利於在活體内或活體外包含可促進 彳益細菌生長或抑制競爭細菌生長之額外試劑。該等額外 物質之實例可能包括: ⑴選擇性抗生素物質,其可抑制革蘭氏陰性細菌生長而 對革蘭氏陽性細菌(例如乳桿菌及雙歧桿菌)影響較小。 ⑺選擇性抗生素物質,其可抑制革蘭氏陽性細菌生長而 對革蘭氏陰性細菌(例如擬桿菌屬)影響較小。 ,7 I!激1生菌生長之物質,例如已用於動物飼料中刺 激有益細菌生長的次煙煤腐殖質。 ⑷例如無機或有機酸及驗之物質,其可改變生長系統ΡΗ 130939.doc -26 * 200904340 條件隻化’以利於有益的益生菌微生物生長。 (5)例如氫陰離子及/或具有化學還原電 等物質,苴可将Μ Λ e < 劳之其他化學劑 、變生長系統之氧化還原條件,以刹a 士、, 厭氧微生物(例如輕ρ Μ 丨於有益 1例如擬#動、乳桿菌及雙歧桿菌)生長 實例3·用於選擇及製備含有或不含益生 生 理多醣的組合物及方法。 皿生囷處 多形擬桿菌 種盈生菌食品或腾食補充品調配物,其包含天然夕 形擬桿菌存活細胞 “、、夕 種盃生菌食品或膳食補充品調配物,其包含天然多 多形擬桿菌存活細胞及所選狀促生長劑(其可刺夕 氏陰性厭氧菌生長) -種生產經細菌改質之多醣、寡醣、雙醣 '及單醣之方 ”係在达閉生物反應器系統中使用多形擬桿菌對天然 來源多醣進行酵素降解法。 一種生產具有免疫活性之經細菌改質的多醣及募醣的方 法,其係使用多形擬桿菌對天然來源多醣進行酵素降解法。 跪弱擬桿菌 種盈生菌食品或膳食補充品調配物’其包含天然多醣 及脆弱擬桿菌存活細胞。 一種益生菌食品或膳食補充品調配物,其包含天然多醣 與脆弱擬桿菌存活細胞及所選用之促生長劑(其可刺激革 蘭氏陰性厭氧菌生長 種生產經細菌改質之多醣、寡醣、雙醣、及單醣之方 130939.doc -27- 200904340 天然 法’其係在密閉生物反應器系統中使用脆弱擬桿菌對 來源多畴進行酵素降解法。 、-種生產具有免疫活性之經細菌改質的多醣及寡醣的方 法,其係使用脆弱擬桿菌對天然來源多醣進行酵素降解法。 長雙歧桿菌 ' -種益生菌食品或膳食補充品調配物,其包含天然多醣 及長雙歧桿菌存活細胞。 -種益生菌食品或膳食補充品調配物’其包含天然多醣 與長雙歧桿菌存活細胞及所選用之促生長劑(其可刺激厭 氣生長)。 一種生產經細菌改質之多醣、寡醣、雙醣、及單醣之方 法,其係在密閉生物反應器系統中使用長雙歧桿菌對天然 來源多醣進行酵素降解法。 一種生產具有免疫活性之經細菌改質的多醣及寡醣的方 法,其係使用長雙歧桿菌對天然來源多醋進行酵素降解法。 原腸球菌 一種益生菌食品或膳食補充品調配物,其包含天然多醣 及辱腸球痛存活細胞。 一種益生菌食品或膳食補充品調配物,其包含天然多聽 與屎腸球菌存活細胞及所選用之促生長劑(其可刺激革蘭 氏陰性厭氧菌生長)。 一種生產經細菌改質之多醣、寡醣、雙醣、及單醣之方 法’其係在密閉生物反應器系統中使用屎腸球菌對天然來 源多醣進行酵素降解法。 130939.doc -28 - 200904340 一種生產具有免疫活性之經細菌改質的多醣及寡醣的方 法,其係使用屎腸球菌對天然來源多醣進行酵素降解法。 多種益生菌 自以下之群中選擇特定的非病原性食品處理微生物:乳 桿菌、乳球菌、鏈球菌、腸球菌、明串珠菌、醋桿菌、念 珠菌、克魯弗氏酵母、酵母菌、串酵母菌、有孢圓酵母 菌、德巴利酵母菌、接合糖酵母菌、擬桿菌、芽孢桿菌、 雙歧桿菌、真細菌、消化鏈球菌、瘤胃球菌及片球菌,該 等微生物具有利用選自以下之群的多醣來產生多醣、寡 聽、雙醣及單醣的能力:葡甘露聚糖'產蒼葡甘露聚糖、 魔芋葡甘露聚糖、半乳甘露聚糖、阿拉伯半乳聚糖、落葉 松阿拉伯半乳聚糖、海藻多醣、岩藻依聚糖、真菌多醣、 真菌葡甘露聚糖、黃蓍膠、印度膠、黃原膠、纟爾豆膠、 及金合歡樹膠及其組合。 一或多種選自以下之群的多醣:葡甘露聚糖、蘆薈葡甘 露聚糖、魔芋葡甘露聚糖、半乳甘露聚糖、阿拉伯半乳聚 糖、落葉松阿拉伯半乳聚糖、海藻多冑、岩藻依聚糖、直 菌多醣、真菌葡甘露聚糖、黃着膠、印度膠、黃原膠、瓜 爾豆膠、及金合歡樹膠’與選自以下之群的非病原性微生 物=存活細胞相結合以產生益生菌膳食補充品或食品: 礼才干囷、乳球菌、鏈球菌、腸球菌、明串珠菌、醋桿菌、 =珠菌、克魯弗氏酵母、酵母s、圓酵母菌、有孢圓酵母 菌 ' 巴利酵母菌、接合糖酵母菌、擬桿菌、芽孢桿菌、 雙歧桿®、真細菌、,;肖化鏈球菌、瘤胃球_及片球菌。 130939.doc •29- 200904340 -種使用選自以下之群的非病原微生物物種:乳桿菌、 乳球菌、鏈球菌、腸球菌、明串珠菌、醋桿菌、念珠菌、 克魯弗氏酵母、酵母g、圓酵母g、有孢圓酵判、德巴 利酵母菌、接合糖酵母菌、擬桿菌、芽抱桿菌、雙歧桿 菌、真細菌、消化鏈球菌、瘤胃球菌及片球菌,以在—密 閉生物反應器系統中產生部分降解多醣、募醣、雙醣、及 單醣以影響選自以下之群的天然來源多醣的酵素降解的方 法:葡甘露聚糖、蘆薈葡甘露聚糖、魔芋葡甘露聚糖、半 乳甘露聚糖、阿拉伯半乳聚糖、落葉松阿拉伯半乳聚糖、 海藻多醣、岩藻依聚糖、真菌多醣、真菌葡甘露聚糖、黃 蓍膠、印度膠、黃原膠、瓜爾豆膠、及金合歡樹 膠。 一種使用選自以下之群的非病原微生物物種:乳桿菌、 乳球菌、鏈球菌、腸球菌、明串珠菌、醋桿菌、念珠菌、 克魯弗氏酵母、酵母菌、圓酵母菌、有孢圓酵母菌、德巴 利酵母菌、接合糖酵母菌、擬桿菌、芽孢桿菌、雙歧桿 菌、真細菌、消化鏈球菌、瘤胃球菌及片球菌,以在一密 閉生物反應器系統中產生具有免疫活性之部分降解多醣及 寡聽以影響選自以下之群的天然來源多醣的酵素降解的方 法:葡甘露聚糖、蘆薈葡甘露聚糖、魔芋葡甘露聚糖、半 乳甘露聚糖、阿拉伯半乳聚糖、落葉松阿拉伯半乳聚糖、 海藻多醣、岩藻依聚糖、真菌多醣、真菌葡甘露聚糖、黃 蓍膠、印度膠、黃原膠、瓜爾豆膠、及金合歡樹 膠。 130939.doc • 30 - 200904340 本發明涵蓋,該說明書中所討論之任—實施例可根據本 發月之任—方法、套組、試劑、或組合物實施,且反之亦 然。而且,本發明之組合物可用於達成本發明之方法。 應瞭解本文所述之具體實施例以說明方式展示而非限制 本發明。本發明之主要特徵可在多個實施例中應用而不背 離本發明之範脅。熟習此項技術者使用常規實驗即可瞭解 或能識別本文所述本發明具體方法之諸多等效物。該等等 效物被認為在本發明範圍内且為中請專利範圍所囊括。 本說明書中所提及之所有公開案及專财請案皆表示孰 習本發明所涉及技術者之熟練程度。所有出版物及專利申 請案均以引用的方式併入本文中,其程度如將各個別出版 物或專利申請案特定及個別所指以引用方式併入本文中。 ;在申請專利範圍及/或說明書中,詞語"一(a^n)”在與 w包含”連用時可能意指"一個”,但亦與,,—或多個"、”至 少-個”及"-或多於一個”之含義相一致。儘管本發明揭 不内容支持所用術語|,或|,可僅指替代及指,,及/或”之定義, 但除非明確表明此術語僅指替代或該等f代互斥,否則申 請專利範圍中所用術語"或"皆係用來指"及/或、在整” 申請案中’術語”約"係用來表明,一值包括用來測量該值 之裝置、方法之内在誤差變化或存在於研究主體中之變 化。 該說明書及申請專利範圍中所用詞語”包人 (comprising)”(及其任—形式,例如"comprise” I ”c⑽pHses”)、”具有(having)"(及其任一形式,例如 130939.doc 200904340 及has )、’’包括(including)"(及其任一形式,例如 includes 及 ”inciude")或”含有(c〇ntaining)”(及其任一形 式,例如"contains”及"contain")皆係指囊括各種情況或無 限制,且不排除另外的未列出之要素或方法步驟。 本文所用術語"或其組合"意指該術語前列項目之所有排 列及組合。舉例而言,"A、B、c、或其組合,,至少意欲包 括以下之一種:A、B、C、AB、AC、BC、或ABC ’且在 特定上下文中若順序很重要,則亦包括BA、CA、cB、 CBA、BCA、ACB、BAC '或CAB。繼續該實施,在表述 上包括包含重複一或多個項目或術語之組合,例如、 AAA、MB、BBC、AAABCCCC、CBBAAA ' CABABB、 及諸如此類。熟習此項技術者將瞭解,除非上下文中另外 指明’任一組合中之項目或術語數量通常並無限制。 藉助本揭示内容無需過多實驗即可獲得並實施本文所揭 不及提出申請之所有組合物及/或方法。雖然本發明之組 合物及方法已根據較佳實施例予以闡述’但熟習此項技術 者可明瞭,可改變該等組合物及/或方法及本文所述方法 之步驟或步驟之順序,此並不背離本發明之概念、精神及 範圍。熟習此項技術者所顯見之所有該等類似替代物及修 改皆被視為涵蓋於隨附申請專利範圍所界定的本發明之精 神、範圍及概念内。 參考文獻
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Claims (1)
- 200904340 十、申請專利範圍: 1. 一種膳食補充品,其包含: 種由先在生物反應器系統中與益生菌一起培育的一 或:種天然多醣所製造之補充品’其中該等細菌處理該 等1糖且由所得經處理多醣用於該營養補充品中。 月长項1之補充品,其中該來自該生物反應器之經處 理=膽適用於食品或膳食補充品中。 3.如。月求項1之補充品,其中將該等經處理多醣調配 次劑型。 4’ 士味^項1之補充品,其中該等多醣包含以下至少一 種:《甘露聚糖、i薈葡甘露聚糖、魔芋葡甘露聚糖、 Λ、I漱糖、阿拉伯半乳聚糖、落葉松阿拉伯半乳聚 糖=藻夕醣、岩藻依聚糖、真菌多醣、真菌葡甘露聚 θ蓍膠、印度膠、黃原膠、瓜爾豆膠、及金合歡樹 膠。 5 . 如5青求項1夕Μ * σ H雨充。α ’其中該等多醣及該等益生菌分開 升> 成單次劑型。月、托項1之補充品’其中將該等多醣與該等益生菌在 生物反應器中培育。 士 1求項1之補充品’其中該等多醣與該等益生菌呈持 續釋玫形式。 月、托項1之補充品,其中該等多醣為雜多醣、同多醣 或一者皆有。 月二項1之補充品’其中將該等多醣自微生物細胞分 130939.doc 200904340 離’並將該經分離多餹加入選自粉末、膠囊、軟膠囊、 錠劑、發泡錠、液體劑或黏性劑之劑型中。 ίο. —種益生菌食品或腊食補充品調配物,其包含一或多種 天然多醣及選自以下至少一種之存活微生物細胞:乳酸 逢、乳球菌、鍵球菌 、腸球菌(五„ier〇c〇cc似)、明串珠菌 (Zewconosioc)、醋桿菌、念珠菌 (Cawc^i/β)、克魯弗氏酵母(尺Ywver〇WyCe>y)、酵母菌 (Sacc/mrowva)、圓酵母菌(r〇rw/a)、有孢圓酵母菌 (Γοα/α印ora)、德巴利酵母菌(Z)ekr>;£?w>;ce5)、接合糖 酵母菌(ZjgoMcc/zaromwa)、擬桿菌、芽 孢桿菌(5ac///Wly)、雙歧桿菌⑺的士⑺·謂)、真細菌 CEMaci⑺·謂)、消化鏈球菌(pe;?io他epi〇 COCCW5)、瘤胃 球菌(^Mmkococcws)及片球菌(pe山_oc〇CCWiS) 〇 1 1 ·如請求項1 〇之調配物,其中該等多醣包含以下中至少一 種:葡甘露聚糖、蘆薈葡甘露聚糖、魔芋葡甘露聚糖、 半乳甘露聚糖、阿拉伯半乳聚糖、落葉松阿拉伯半乳聚 糖、海藻多醣、岩藻依聚糖、真菌多醣、真菌葡甘露聚 糖、黃蓍膠、印度膠、黃原膠、瓜爾豆膠(glw)、 及金合歡樹膠。 12_如請求項1〇之調配物,其中該等多醣與該等存活微生物 細胞分開形成單次劑型。 13.如請求項1〇之調配物,其中該等多醣與該等存活微生物 細胞在生物反應器中培育。 130939.doc 200904340 14. 15. 16. 17. 18. 19. 20. 21. 如請求項1 0之調配物,其中該等多醣與該等存活微生物 細胞呈持續釋放形式。 如請求項1 〇之調配物,其中該等多醣為雜多醣、同多醣 或一者皆有。 一種呈單次劑型之膳食補充品,其包含天然多醣及非病 原性益生菌微生物物種。 如請求項1 6之膳食補充品,其中提供該天然多醣與該等 非病原性益生菌微生物物種同時進入人類胃腸道中。 如請求項16之膳食補充品,其中該等非病原性益生菌微 生物物種係在人類胃腸道區域處理該天然多醣。 如請求項16之膳食補充品,其中該等微生物細胞包含以 下至少一種:乳桿菌、乳球菌、鏈球菌、腸球菌、明串 珠菌、醋桿菌、念珠菌、克魯弗氏酵母、酵母菌、圓酵 母菌、有孢.圓酵母菌、德巴利酵母菌、接合糖酵母菌、 擬和·菌、芽孢桿菌、雙歧桿菌、真細菌、消化鏈球菌、 瘤胃球菌及片球菌。 如請求項16之膳食補充品,其中該等多醣包含以下至少 -種:葡甘露聚糖、蘆薈葡甘露聚糖、魔芋葡甘露聚 糖、半乳甘露聚糖、阿拉伯半乳聚糖、落葉松阿拉伯半 乳聚糖、海藻多醋、岩藻依聚糖 '真菌多_、真菌葡甘 露聚糖、黃Ϊ膠、印度膠、黃原膠、瓜 歡樹膠。 ^ ° 130939.doc 200904340 取物。 22. —種製備膳食補充品之方法,其包括. 在生物反應器系統中,於可刺激細菌對天然多膽進行 處理之條件下混合-或多種天然多.與益生菌,以產生 經處理多醣;及 在至少一部分該等天然多畴已經過該等細菌處理後製 備該膳食補充品。 23. 如請求項22之方法’其中該等細菌處理該等多醣並將所 得經處理多醣製成單次劑量營養補充品。 24. 如請求項22方法,其進—步包括以下步驟: 自該等天然多醣及該等細菌分離該等經處理多醋;及 製備包含該等經處理多醣的劑型。 25. 如請求項22方法,其進—步包括製備包含該等經處理多 醣、該等天然多醣及該等細菌之劑型的步驟。 26. 如請求項22方法’其進一步包括將該等經處理多酿加至 選自粉末、膠囊、軟膠囊、錠劑、發泡錠' 液體劑或黏 性劑等劑型中。 27. 如請求項22方法,其中該等細菌包含以下中之至少— 種:乳桿菌、乳球菌、鏈球菌、腸球菌、明争珠菌、醋 桿菌、念珠菌、克魯弗氏酵母、酵母菌、圓酵母菌、; 孢圓酵母菌、德巴輯判、接合㈣判、擬桿菌、 芽抱桿菌、雙歧桿菌、真細菌、消化鏈球菌、瘤胃球菌 及片球菌。 28. 如請求項22之方法,其中該等天然多黯包含以下至少_ 130939.doc 200904340 種:葡甘露聚糖、盘薈葡甘露聚糖、魔竿葡甘露聚糖、 半乳甘露聚糖、阿拉伯半乳聚糖、落葉松阿拉伯半乳聚 糖、海藻多醣、岩藻依聚糖、真菌多醣、真菌葡甘露聚 糖、黃着膠、印度膠、黃原膠、瓜爾豆膠、及金合歡樹 膠。 29. 如請求項22之方法’其中該等經處理多醣係自該等細菌 中分離,並將該等經處理多骑加至選自粉末、㈣、軟 膠囊、錠劑、發泡錠、液體劑或黏性劑等劑型中。人 30. —種膳食補充品或食品,其包含: 在生物反應器或發酵槽系統中與益生菌—起培育之經 處理產薈内葉膠,其中該等細菌將董薈内葉膠處理為、^ 物可利用產物。 31·如請求項30之產品,其中該等益生菌包含選自以下中之 至少:種細菌:乳桿菌、乳球菌、鏈球菌、腸球菌、明 串珠菌、醋桿g、念珠菌、克魯弗氏酵母、酵母菌、圓 酵母菌、有孢圓酵母菌、德巴利酵母菌、接合糖酵母 :、擬桿菌、芽孢桿菌、雙歧桿菌、真細菌、消化鏈球 痛、瘤胃球菌及片球菌。 130939.doc 200904340 七、指定代表圖: (一) 本案指定代表圖為:(無) (二) 本代表圖之元件符號簡單說明: 八、本案若有化學式時,請揭示最能顯示發明特徵的化學式: (無) 130939.doc
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2008
- 2008-05-05 TW TW097116524A patent/TW200904340A/zh unknown
- 2008-05-09 MX MX2009012140A patent/MX2009012140A/es active IP Right Grant
- 2008-05-09 CA CA002687083A patent/CA2687083A1/en not_active Abandoned
- 2008-05-09 BR BRPI0811131-6A2A patent/BRPI0811131A2/pt not_active IP Right Cessation
- 2008-05-09 WO PCT/US2008/063329 patent/WO2008141240A1/en active Application Filing
- 2008-05-09 EP EP08769425.3A patent/EP2155768B1/en not_active Not-in-force
- 2008-05-09 CN CN200880023924A patent/CN101687897A/zh active Pending
- 2008-05-09 AR ARP080101994A patent/AR066900A1/es active IP Right Grant
- 2008-05-09 EP EP16206683.1A patent/EP3170410A3/en not_active Withdrawn
- 2008-05-09 NZ NZ581043A patent/NZ581043A/en unknown
- 2008-05-09 US US12/118,604 patent/US9415056B2/en active Active
- 2008-05-09 KR KR1020097025706A patent/KR101493302B1/ko active IP Right Grant
- 2008-05-09 AU AU2008251346A patent/AU2008251346B2/en active Active
- 2008-05-09 JP JP2010507710A patent/JP2010526539A/ja active Pending
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2009
- 2009-11-16 ZA ZA200908063A patent/ZA200908063B/xx unknown
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2015
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Also Published As
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KR101493302B1 (ko) | 2015-02-13 |
US20080286252A1 (en) | 2008-11-20 |
EP2155768A4 (en) | 2014-02-19 |
KR20100017731A (ko) | 2010-02-16 |
EP2155768A1 (en) | 2010-02-24 |
AR066900A1 (es) | 2009-09-23 |
US20170173067A1 (en) | 2017-06-22 |
EP2155768B1 (en) | 2017-05-03 |
ZA200908063B (en) | 2010-09-29 |
US9855288B2 (en) | 2018-01-02 |
MX2009012140A (es) | 2009-12-11 |
NZ581043A (en) | 2011-11-25 |
BRPI0811131A2 (pt) | 2014-12-23 |
EP3170410A3 (en) | 2017-06-21 |
JP2010526539A (ja) | 2010-08-05 |
US9415056B2 (en) | 2016-08-16 |
AU2008251346B2 (en) | 2012-11-22 |
WO2008141240A1 (en) | 2008-11-20 |
CA2687083A1 (en) | 2008-11-20 |
CN101687897A (zh) | 2010-03-31 |
AU2008251346A1 (en) | 2008-11-20 |
US10117884B2 (en) | 2018-11-06 |
EP3170410A2 (en) | 2017-05-24 |
US20150306121A1 (en) | 2015-10-29 |
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