BRPI0811131A2 - Processamento de polissacarídeos naturais por micro-organismos não-patogênicos selecionados e métodos de fazer e usar os mesmos - Google Patents
Processamento de polissacarídeos naturais por micro-organismos não-patogênicos selecionados e métodos de fazer e usar os mesmosInfo
- Publication number
- BRPI0811131A2 BRPI0811131A2 BRPI0811131-6A2A BRPI0811131A BRPI0811131A2 BR PI0811131 A2 BRPI0811131 A2 BR PI0811131A2 BR PI0811131 A BRPI0811131 A BR PI0811131A BR PI0811131 A2 BRPI0811131 A2 BR PI0811131A2
- Authority
- BR
- Brazil
- Prior art keywords
- making
- methods
- processing
- same
- pathogenic microorganisms
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title 1
- 244000000010 microbial pathogen Species 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91733907P | 2007-05-11 | 2007-05-11 | |
PCT/US2008/063329 WO2008141240A1 (en) | 2007-05-11 | 2008-05-09 | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0811131A2 true BRPI0811131A2 (pt) | 2014-12-23 |
Family
ID=40002629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0811131-6A2A BRPI0811131A2 (pt) | 2007-05-11 | 2008-05-09 | Processamento de polissacarídeos naturais por micro-organismos não-patogênicos selecionados e métodos de fazer e usar os mesmos |
Country Status (14)
Country | Link |
---|---|
US (3) | US9415056B2 (pt) |
EP (2) | EP2155768B1 (pt) |
JP (1) | JP2010526539A (pt) |
KR (1) | KR101493302B1 (pt) |
CN (1) | CN101687897A (pt) |
AR (1) | AR066900A1 (pt) |
AU (1) | AU2008251346B2 (pt) |
BR (1) | BRPI0811131A2 (pt) |
CA (1) | CA2687083A1 (pt) |
MX (1) | MX2009012140A (pt) |
NZ (1) | NZ581043A (pt) |
TW (1) | TW200904340A (pt) |
WO (1) | WO2008141240A1 (pt) |
ZA (1) | ZA200908063B (pt) |
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CN103083642B (zh) * | 2007-05-11 | 2015-11-18 | 芦荟研究实验室公司 | 用于皮肤增强的芦荟制剂 |
US10644163B2 (en) * | 2008-08-27 | 2020-05-05 | Idemitsu Kosan Co., Ltd. | Semiconductor film comprising an oxide containing in atoms, Sn atoms and Zn atoms |
US7833829B2 (en) * | 2008-10-28 | 2010-11-16 | Honeywell International Inc. | MEMS devices and methods of assembling micro electromechanical systems (MEMS) |
JP5606672B2 (ja) * | 2008-11-26 | 2014-10-15 | 太陽化学株式会社 | シンバイオティクスを利用した腸内環境調整方法 |
JP2010273569A (ja) * | 2009-05-26 | 2010-12-09 | Wasaburo Sato | メタボリックシンドローム改善作用を有する飲料及びサプリメント |
US20100311686A1 (en) * | 2009-06-03 | 2010-12-09 | Kasper Lloyd H | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
US8580278B2 (en) | 2009-06-03 | 2013-11-12 | Trustees Of Dartmouth College | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
FR2955774A1 (fr) | 2010-02-02 | 2011-08-05 | Aragan | Preparation destinee a traiter l'exces ponderal et les desordres associes et applications de ladite preparation |
WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
CN110201003A (zh) | 2012-02-29 | 2019-09-06 | 伊西康内外科公司 | 微生物区系的组合物及与其相关的方法 |
BR112014024159A2 (pt) | 2012-03-29 | 2017-06-20 | Therabiome Llc | Formulações de vacina oral específicas do local gastrintestinal , ativas no íleo e apêndice. |
WO2014074770A2 (en) | 2012-11-09 | 2014-05-15 | Heliae Development, Llc | Balanced mixotrophy methods |
WO2014074772A1 (en) | 2012-11-09 | 2014-05-15 | Heliae Development, Llc | Mixotrophic, phototrophic, and heterotrophic combination methods and systems |
US9907755B2 (en) | 2013-03-14 | 2018-03-06 | Therabiome, Llc | Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents |
EP2876167A1 (en) | 2013-11-21 | 2015-05-27 | Institut Gustave Roussy | Microbiota composition, as a marker of responsiveness to chemotherapy, and use of microbial modulators (pre-,pro- or synbiotics) for improving the efficacy of a cancer treatment |
GB2551642B (en) | 2014-10-31 | 2020-09-23 | Pendulum Therapeutics Inc | Methods and compositions relating to microbial treatment and diagnosis of disorders |
WO2017031431A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
EP3484441A4 (en) | 2016-07-15 | 2020-03-18 | President and Fellows of Harvard College | GLYCOLIPID COMPOSITIONS AND METHODS OF USE |
WO2019046646A1 (en) | 2017-08-30 | 2019-03-07 | Whole Biome Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS |
EP3766359A4 (en) * | 2018-03-16 | 2021-12-15 | Ajinomoto Co., Inc. | FEED ADDITIVES AND FEED |
WO2019231393A1 (en) * | 2018-05-31 | 2019-12-05 | Ngee Ann Polytechnic | D-psicose production using probiotic microorganisms |
US11273123B2 (en) | 2018-07-18 | 2022-03-15 | USpharma Ltd | Chewable pharmaceutical dosage forms |
CN111820419B (zh) * | 2020-07-24 | 2022-05-27 | 中国海洋大学 | 靶向调控肠道艾克曼菌和短链脂肪酸产生菌的组合物 |
CN111961698A (zh) * | 2020-08-27 | 2020-11-20 | 桂林理工大学 | 一种利用短乳杆菌产酶降解西番莲果皮多糖的制备方法及其应用 |
CN112501049B (zh) * | 2020-10-28 | 2022-04-19 | 石河子大学 | 产转糖基活性β-半乳糖苷酶的开菲尔乳杆菌及制备的β-半乳糖苷酶生产低聚半乳糖的方法 |
CN112741272B (zh) * | 2021-01-18 | 2023-02-28 | 黑龙江中医药大学 | 一种高含量纳豆激酶的纳豆冻干粉的发酵方法 |
CN113303475B (zh) * | 2021-06-18 | 2022-06-14 | 湖南营养树生物科技有限公司 | 一种功能性益生菌剂及其制备方法 |
CN115261426B (zh) * | 2022-09-26 | 2023-01-03 | 东北农业大学 | 一种具有抗氧化能力的两歧双歧杆菌e3胞外多糖 |
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-
2008
- 2008-05-05 TW TW097116524A patent/TW200904340A/zh unknown
- 2008-05-09 US US12/118,604 patent/US9415056B2/en active Active
- 2008-05-09 NZ NZ581043A patent/NZ581043A/en unknown
- 2008-05-09 JP JP2010507710A patent/JP2010526539A/ja active Pending
- 2008-05-09 CN CN200880023924A patent/CN101687897A/zh active Pending
- 2008-05-09 AU AU2008251346A patent/AU2008251346B2/en active Active
- 2008-05-09 EP EP08769425.3A patent/EP2155768B1/en not_active Not-in-force
- 2008-05-09 BR BRPI0811131-6A2A patent/BRPI0811131A2/pt not_active IP Right Cessation
- 2008-05-09 CA CA002687083A patent/CA2687083A1/en not_active Abandoned
- 2008-05-09 EP EP16206683.1A patent/EP3170410A3/en not_active Withdrawn
- 2008-05-09 MX MX2009012140A patent/MX2009012140A/es active IP Right Grant
- 2008-05-09 AR ARP080101994A patent/AR066900A1/es active IP Right Grant
- 2008-05-09 WO PCT/US2008/063329 patent/WO2008141240A1/en active Application Filing
- 2008-05-09 KR KR1020097025706A patent/KR101493302B1/ko active IP Right Grant
-
2009
- 2009-11-16 ZA ZA200908063A patent/ZA200908063B/xx unknown
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2015
- 2015-07-09 US US14/795,664 patent/US9855288B2/en active Active
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2016
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Also Published As
Publication number | Publication date |
---|---|
US9855288B2 (en) | 2018-01-02 |
AR066900A1 (es) | 2009-09-23 |
KR20100017731A (ko) | 2010-02-16 |
US20150306121A1 (en) | 2015-10-29 |
US9415056B2 (en) | 2016-08-16 |
US20080286252A1 (en) | 2008-11-20 |
ZA200908063B (en) | 2010-09-29 |
CA2687083A1 (en) | 2008-11-20 |
US10117884B2 (en) | 2018-11-06 |
EP2155768A1 (en) | 2010-02-24 |
JP2010526539A (ja) | 2010-08-05 |
US20170173067A1 (en) | 2017-06-22 |
KR101493302B1 (ko) | 2015-02-13 |
WO2008141240A1 (en) | 2008-11-20 |
EP3170410A2 (en) | 2017-05-24 |
EP2155768A4 (en) | 2014-02-19 |
EP3170410A3 (en) | 2017-06-21 |
AU2008251346B2 (en) | 2012-11-22 |
CN101687897A (zh) | 2010-03-31 |
EP2155768B1 (en) | 2017-05-03 |
NZ581043A (en) | 2011-11-25 |
AU2008251346A1 (en) | 2008-11-20 |
TW200904340A (en) | 2009-02-01 |
MX2009012140A (es) | 2009-12-11 |
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