TW200528472A - Inhibitors of serine proteases, particularly HCV ns3-ns4a protease - Google Patents

Inhibitors of serine proteases, particularly HCV ns3-ns4a protease Download PDF

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Publication number
TW200528472A
TW200528472A TW093130680A TW93130680A TW200528472A TW 200528472 A TW200528472 A TW 200528472A TW 093130680 A TW093130680 A TW 093130680A TW 93130680 A TW93130680 A TW 93130680A TW 200528472 A TW200528472 A TW 200528472A
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TW
Taiwan
Prior art keywords
ring
group
aryl
heteroaryl
heterocyclyl
Prior art date
Application number
TW093130680A
Other languages
English (en)
Chinese (zh)
Inventor
Kevin M Cottrell
Robert B Perni
Janos Pitlik
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200528472A publication Critical patent/TW200528472A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
TW093130680A 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly HCV ns3-ns4a protease TW200528472A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51015603P 2003-10-10 2003-10-10
US51376803P 2003-10-23 2003-10-23

Publications (1)

Publication Number Publication Date
TW200528472A true TW200528472A (en) 2005-09-01

Family

ID=34467967

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093130680A TW200528472A (en) 2003-10-10 2004-10-08 Inhibitors of serine proteases, particularly HCV ns3-ns4a protease

Country Status (14)

Country Link
US (2) US7208600B2 (US08039623-20111018-C00100.png)
EP (2) EP2361925A1 (US08039623-20111018-C00100.png)
JP (2) JP2007532474A (US08039623-20111018-C00100.png)
KR (2) KR20120010278A (US08039623-20111018-C00100.png)
CN (1) CN101857631A (US08039623-20111018-C00100.png)
AU (1) AU2004282148A1 (US08039623-20111018-C00100.png)
CA (1) CA2541634A1 (US08039623-20111018-C00100.png)
IL (1) IL174863A0 (US08039623-20111018-C00100.png)
MX (1) MXPA06004006A (US08039623-20111018-C00100.png)
NO (1) NO20062101L (US08039623-20111018-C00100.png)
NZ (1) NZ546663A (US08039623-20111018-C00100.png)
RU (1) RU2006115558A (US08039623-20111018-C00100.png)
TW (1) TW200528472A (US08039623-20111018-C00100.png)
WO (1) WO2005037860A2 (US08039623-20111018-C00100.png)

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AU2004282148A1 (en) 2005-04-28
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NO20062101L (no) 2006-07-05
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IL174863A0 (en) 2008-02-09
US7208600B2 (en) 2007-04-24
WO2005037860A3 (en) 2005-11-10
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EP1692157A2 (en) 2006-08-23
KR20120010278A (ko) 2012-02-02
US8039623B2 (en) 2011-10-18
CN101857631A (zh) 2010-10-13
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US20050137140A1 (en) 2005-06-23

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