TW200512211A - 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents - Google Patents

6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Info

Publication number
TW200512211A
TW200512211A TW093128500A TW93128500A TW200512211A TW 200512211 A TW200512211 A TW 200512211A TW 093128500 A TW093128500 A TW 093128500A TW 93128500 A TW93128500 A TW 93128500A TW 200512211 A TW200512211 A TW 200512211A
Authority
TW
Taiwan
Prior art keywords
mammal
compounds
pharmaceutically acceptable
acceptable salts
phenyl
Prior art date
Application number
TW093128500A
Other languages
English (en)
Chinese (zh)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Thai Hiep Nguyen
yan-zhong Wu
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200512211A publication Critical patent/TW200512211A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW093128500A 2003-09-24 2004-09-21 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents TW200512211A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
TW200512211A true TW200512211A (en) 2005-04-01

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093128500A TW200512211A (en) 2003-09-24 2004-09-21 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Country Status (30)

Country Link
US (1) US7507739B2 (enExample)
EP (1) EP1680425B1 (enExample)
JP (1) JP2007506744A (enExample)
KR (1) KR20060098368A (enExample)
CN (1) CN100519559C (enExample)
AR (1) AR045810A1 (enExample)
AU (1) AU2004276240A1 (enExample)
BR (1) BRPI0414700A (enExample)
CA (1) CA2539252A1 (enExample)
CO (1) CO5690598A2 (enExample)
CR (1) CR8288A (enExample)
CY (1) CY1106392T1 (enExample)
DE (1) DE602004004295T8 (enExample)
DK (1) DK1680425T3 (enExample)
EC (1) ECSP066458A (enExample)
ES (1) ES2279452T3 (enExample)
GT (1) GT200400190A (enExample)
IL (1) IL174281A0 (enExample)
MX (1) MXPA06003206A (enExample)
NO (1) NO20061318L (enExample)
PA (1) PA8613301A1 (enExample)
PE (1) PE20050433A1 (enExample)
PL (1) PL1680425T3 (enExample)
PT (1) PT1680425E (enExample)
RU (1) RU2006107579A (enExample)
SA (1) SA04250302A (enExample)
SI (1) SI1680425T1 (enExample)
TW (1) TW200512211A (enExample)
WO (1) WO2005030775A1 (enExample)
ZA (1) ZA200602387B (enExample)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
JP2004502691A (ja) * 2000-06-30 2004-01-29 ワイス 抗癌薬としての置換トリアゾロピリミジン
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
BRPI0414700A (pt) 2003-09-24 2006-11-14 Wyeth Corp 6-[(substituìdo)fenil]triazolopirimidinas como agentes anti-cáncer
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
EP1891052A1 (en) * 2005-06-13 2008-02-27 Wyeth Tubulin inhibitor and process for its preparation
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
CN101208289A (zh) * 2005-06-27 2008-06-25 巴斯福股份公司 生产取代的苯基丙二酸酯中间体化合物的方法及其在生产5,7-二羟基-6-(2,4,6-三氟苯基)[1,2,4]三唑并[1,5-a]嘧啶中的用途
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
TW200730530A (en) * 2005-12-16 2007-08-16 Wyeth Corp Lyophilized compositions of a triazolopyrimidine compound
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
WO2014047257A2 (en) 2012-09-19 2014-03-27 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
AU2021255495A1 (en) * 2020-04-14 2022-12-15 The Regents Of The University Of California Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (enExample) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
AU6558498A (en) 1997-03-18 1998-10-12 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
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US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
AU750489B2 (en) 1998-02-11 2002-07-18 Wyeth Holdings Corporation Fungicidal 7-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
WO1999048893A1 (en) 1998-03-23 1999-09-30 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) * 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5986135A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
DE69914364T2 (de) 1998-09-25 2004-07-22 Basf Ag Nicht-wässriges suspensionskonzentrat
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US6521628B1 (en) * 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) * 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
WO2001035738A2 (en) * 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
JP2004502691A (ja) * 2000-06-30 2004-01-29 ワイス 抗癌薬としての置換トリアゾロピリミジン
MXPA03001263A (es) * 2000-08-25 2003-06-24 Basf Ag Formulacion fungicida.
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
EP1368351A2 (de) 2000-11-13 2003-12-10 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen
TR200402494T4 (tr) 2000-12-06 2004-12-21 Wyeth Mantar öldürücü 6-(2-triflorometil-fenil)-triazolopirimidinler.
DE10063115A1 (de) * 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ES2236509T3 (es) 2001-04-11 2005-07-16 Basf Aktiengesellschaft 5-halogen-6-fenil-7-fluoroalquilamino-triazolopirimidinas utiles como fungicidas.
DE10124208A1 (de) * 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
US7038047B2 (en) 2001-07-18 2006-05-02 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl) triazolopyrimides as fungicides
BRPI0414700A (pt) 2003-09-24 2006-11-14 Wyeth Corp 6-[(substituìdo)fenil]triazolopirimidinas como agentes anti-cáncer

Also Published As

Publication number Publication date
ECSP066458A (es) 2006-09-18
JP2007506744A (ja) 2007-03-22
CN100519559C (zh) 2009-07-29
MXPA06003206A (es) 2006-06-23
WO2005030775A1 (en) 2005-04-07
AU2004276240A1 (en) 2005-04-07
PE20050433A1 (es) 2005-07-21
US20050090508A1 (en) 2005-04-28
CO5690598A2 (es) 2006-10-31
SI1680425T1 (sl) 2007-04-30
CN1867569A (zh) 2006-11-22
US7507739B2 (en) 2009-03-24
DE602004004295T2 (de) 2007-06-06
GT200400190A (es) 2005-05-02
CA2539252A1 (en) 2005-04-07
ES2279452T3 (es) 2007-08-16
DK1680425T3 (da) 2007-03-19
IL174281A0 (en) 2006-08-01
CR8288A (es) 2006-10-04
DE602004004295D1 (de) 2007-02-22
KR20060098368A (ko) 2006-09-18
EP1680425A1 (en) 2006-07-19
PA8613301A1 (es) 2005-11-25
PT1680425E (pt) 2007-02-28
HK1090374A1 (en) 2006-12-22
BRPI0414700A (pt) 2006-11-14
AR045810A1 (es) 2005-11-16
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
DE602004004295T8 (de) 2007-09-20
NO20061318L (no) 2006-04-21
CY1106392T1 (el) 2011-10-12
EP1680425B1 (en) 2007-01-10
RU2006107579A (ru) 2007-10-27
ZA200602387B (en) 2008-11-26

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