CN100519559C - 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 - Google Patents

作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 Download PDF

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Publication number
CN100519559C
CN100519559C CNB2004800302006A CN200480030200A CN100519559C CN 100519559 C CN100519559 C CN 100519559C CN B2004800302006 A CNB2004800302006 A CN B2004800302006A CN 200480030200 A CN200480030200 A CN 200480030200A CN 100519559 C CN100519559 C CN 100519559C
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CN
China
Prior art keywords
triazolo
pyrimidin
chloro
trifluoro
methylethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2004800302006A
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English (en)
Chinese (zh)
Other versions
CN1867569A (zh
Inventor
张楠
塞米拉米斯·艾拉尔-卡劳斯蒂昂
阮泰协
吴彦中
佟伟
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Publication of CN1867569A publication Critical patent/CN1867569A/zh
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Publication of CN100519559C publication Critical patent/CN100519559C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2004800302006A 2003-09-24 2004-09-17 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶 Expired - Fee Related CN100519559C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
US60/505,544 2003-09-24

Publications (2)

Publication Number Publication Date
CN1867569A CN1867569A (zh) 2006-11-22
CN100519559C true CN100519559C (zh) 2009-07-29

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800302006A Expired - Fee Related CN100519559C (zh) 2003-09-24 2004-09-17 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶

Country Status (30)

Country Link
US (1) US7507739B2 (enExample)
EP (1) EP1680425B1 (enExample)
JP (1) JP2007506744A (enExample)
KR (1) KR20060098368A (enExample)
CN (1) CN100519559C (enExample)
AR (1) AR045810A1 (enExample)
AU (1) AU2004276240A1 (enExample)
BR (1) BRPI0414700A (enExample)
CA (1) CA2539252A1 (enExample)
CO (1) CO5690598A2 (enExample)
CR (1) CR8288A (enExample)
CY (1) CY1106392T1 (enExample)
DE (1) DE602004004295T8 (enExample)
DK (1) DK1680425T3 (enExample)
EC (1) ECSP066458A (enExample)
ES (1) ES2279452T3 (enExample)
GT (1) GT200400190A (enExample)
IL (1) IL174281A0 (enExample)
MX (1) MXPA06003206A (enExample)
NO (1) NO20061318L (enExample)
PA (1) PA8613301A1 (enExample)
PE (1) PE20050433A1 (enExample)
PL (1) PL1680425T3 (enExample)
PT (1) PT1680425E (enExample)
RU (1) RU2006107579A (enExample)
SA (1) SA04250302A (enExample)
SI (1) SI1680425T1 (enExample)
TW (1) TW200512211A (enExample)
WO (1) WO2005030775A1 (enExample)
ZA (1) ZA200602387B (enExample)

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NZ523807A (en) * 2000-06-30 2004-09-24 Wyeth Corp Substituted-triazolopyrimidines as anticancer agents
ES2279452T3 (es) 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
JP2008543838A (ja) * 2005-06-13 2008-12-04 ワイス チューブリンインヒビターおよびその調製のためのプロセス
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
CN101208289A (zh) * 2005-06-27 2008-06-25 巴斯福股份公司 生产取代的苯基丙二酸酯中间体化合物的方法及其在生产5,7-二羟基-6-(2,4,6-三氟苯基)[1,2,4]三唑并[1,5-a]嘧啶中的用途
AU2006329849A1 (en) * 2005-12-16 2007-07-05 Wyeth Lyophilized compositions of a triazolopyrimidine compound
JP2009519954A (ja) * 2005-12-16 2009-05-21 ワイス 抗癌剤として有用な６−［（置換）フェニル］トリアゾロピリミジンの二量体および付加物
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
EP3219207A1 (en) * 2012-09-19 2017-09-20 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
US20230167121A1 (en) * 2020-04-14 2023-06-01 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用
CN118359616A (zh) * 2023-01-19 2024-07-19 中国科学院上海有机化学研究所 一种作为治疗神经系统疾病和肿瘤的多环化合物

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Also Published As

Publication number Publication date
DE602004004295D1 (de) 2007-02-22
HK1090374A1 (en) 2006-12-22
SI1680425T1 (sl) 2007-04-30
ECSP066458A (es) 2006-09-18
PT1680425E (pt) 2007-02-28
JP2007506744A (ja) 2007-03-22
PE20050433A1 (es) 2005-07-21
IL174281A0 (en) 2006-08-01
GT200400190A (es) 2005-05-02
PA8613301A1 (es) 2005-11-25
EP1680425B1 (en) 2007-01-10
TW200512211A (en) 2005-04-01
MXPA06003206A (es) 2006-06-23
DK1680425T3 (da) 2007-03-19
US20050090508A1 (en) 2005-04-28
CA2539252A1 (en) 2005-04-07
BRPI0414700A (pt) 2006-11-14
NO20061318L (no) 2006-04-21
DE602004004295T8 (de) 2007-09-20
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
AR045810A1 (es) 2005-11-16
ZA200602387B (en) 2008-11-26
CO5690598A2 (es) 2006-10-31
CR8288A (es) 2006-10-04
US7507739B2 (en) 2009-03-24
DE602004004295T2 (de) 2007-06-06
EP1680425A1 (en) 2006-07-19
AU2004276240A1 (en) 2005-04-07
KR20060098368A (ko) 2006-09-18
RU2006107579A (ru) 2007-10-27
CN1867569A (zh) 2006-11-22
ES2279452T3 (es) 2007-08-16
WO2005030775A1 (en) 2005-04-07
CY1106392T1 (el) 2011-10-12

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Granted publication date: 20090729

Termination date: 20091019