PT1680425E - 6 - [fenil (substituído)] triazolopirimidinas como agentes contra o cancro. - Google Patents

6 - [fenil (substituído)] triazolopirimidinas como agentes contra o cancro. Download PDF

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Publication number
PT1680425E
PT1680425E PT04788820T PT04788820T PT1680425E PT 1680425 E PT1680425 E PT 1680425E PT 04788820 T PT04788820 T PT 04788820T PT 04788820 T PT04788820 T PT 04788820T PT 1680425 E PT1680425 E PT 1680425E
Authority
PT
Portugal
Prior art keywords
pyrimidin
chloro
trifluoro
triazolo
methylethyl
Prior art date
Application number
PT04788820T
Other languages
English (en)
Portuguese (pt)
Inventor
Semiramis Ayral-Kaloustian
Nan Zhang
Hiep Thai Nguyen
Yanzhong Wu
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PT1680425E publication Critical patent/PT1680425E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT04788820T 2003-09-24 2004-09-17 6 - [fenil (substituído)] triazolopirimidinas como agentes contra o cancro. PT1680425E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
PT1680425E true PT1680425E (pt) 2007-02-28

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04788820T PT1680425E (pt) 2003-09-24 2004-09-17 6 - [fenil (substituído)] triazolopirimidinas como agentes contra o cancro.

Country Status (30)

Country Link
US (1) US7507739B2 (enExample)
EP (1) EP1680425B1 (enExample)
JP (1) JP2007506744A (enExample)
KR (1) KR20060098368A (enExample)
CN (1) CN100519559C (enExample)
AR (1) AR045810A1 (enExample)
AU (1) AU2004276240A1 (enExample)
BR (1) BRPI0414700A (enExample)
CA (1) CA2539252A1 (enExample)
CO (1) CO5690598A2 (enExample)
CR (1) CR8288A (enExample)
CY (1) CY1106392T1 (enExample)
DE (1) DE602004004295T8 (enExample)
DK (1) DK1680425T3 (enExample)
EC (1) ECSP066458A (enExample)
ES (1) ES2279452T3 (enExample)
GT (1) GT200400190A (enExample)
IL (1) IL174281A0 (enExample)
MX (1) MXPA06003206A (enExample)
NO (1) NO20061318L (enExample)
PA (1) PA8613301A1 (enExample)
PE (1) PE20050433A1 (enExample)
PL (1) PL1680425T3 (enExample)
PT (1) PT1680425E (enExample)
RU (1) RU2006107579A (enExample)
SA (1) SA04250302A (enExample)
SI (1) SI1680425T1 (enExample)
TW (1) TW200512211A (enExample)
WO (1) WO2005030775A1 (enExample)
ZA (1) ZA200602387B (enExample)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
HK1052646A1 (zh) * 2000-06-30 2003-09-26 Wyeth 替代三氮苯(triazolopyrimidines)作为抗癌剂
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
CA2539252A1 (en) 2003-09-24 2005-04-07 Wyeth Holdings Corporation 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
CA2610416A1 (en) * 2005-06-13 2006-12-28 Wyeth Tubulin inhibitor and process for its preparation
CN101208289A (zh) * 2005-06-27 2008-06-25 巴斯福股份公司 生产取代的苯基丙二酸酯中间体化合物的方法及其在生产5,7-二羟基-6-(2,4,6-三氟苯基)[1,2,4]三唑并[1,5-a]嘧啶中的用途
EP1963330A1 (en) * 2005-12-16 2008-09-03 Wyeth a Corporation of the State of Delaware Dimers and adducts of 6-[substituted) phenyl] triazolopyrimidines useful as anticancer agents
JP2009519952A (ja) * 2005-12-16 2009-05-21 ワイス トリアゾロピリミジン化合物の凍結乾燥組成物
US20100056371A1 (en) * 2007-01-08 2010-03-04 Basf Se Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi
WO2014047257A2 (en) 2012-09-19 2014-03-27 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
EP4136089A4 (en) * 2020-04-14 2024-05-29 The Trustees of The University of Pennsylvania SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND THEIR USE IN THE STABILIZATION OF MICROTUBULES
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
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HK1052646A1 (zh) * 2000-06-30 2003-09-26 Wyeth 替代三氮苯(triazolopyrimidines)作为抗癌剂
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US6855718B2 (en) 2000-11-13 2005-02-15 Basf Aktiengesellschaft 7-(r)-aminotriazolopyrimidines, the production thereof and use of the same for combatting phytopathogenic fungi
DE60013188T2 (de) 2000-12-06 2004-12-30 Basf Ag Fungiizide 6-(trifluormethyl-phenyl)-triazolpyrimidine
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
BR0208756A (pt) 2001-04-11 2004-05-11 Basf Ag Compostos, processo para a preparação dos mesmos, composição adequada para o controle de fungos fitopatogênicos, e, método para controlar fungos fitopatogênicos
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
EP1412356A1 (en) 2001-07-18 2004-04-28 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl)triazolopyrimidines as fungicides
CA2539252A1 (en) 2003-09-24 2005-04-07 Wyeth Holdings Corporation 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents

Also Published As

Publication number Publication date
DE602004004295D1 (de) 2007-02-22
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
CY1106392T1 (el) 2011-10-12
GT200400190A (es) 2005-05-02
CA2539252A1 (en) 2005-04-07
DK1680425T3 (da) 2007-03-19
DE602004004295T2 (de) 2007-06-06
WO2005030775A1 (en) 2005-04-07
JP2007506744A (ja) 2007-03-22
ECSP066458A (es) 2006-09-18
HK1090374A1 (en) 2006-12-22
US7507739B2 (en) 2009-03-24
CN100519559C (zh) 2009-07-29
ES2279452T3 (es) 2007-08-16
EP1680425B1 (en) 2007-01-10
RU2006107579A (ru) 2007-10-27
KR20060098368A (ko) 2006-09-18
AU2004276240A1 (en) 2005-04-07
ZA200602387B (en) 2008-11-26
BRPI0414700A (pt) 2006-11-14
DE602004004295T8 (de) 2007-09-20
CN1867569A (zh) 2006-11-22
EP1680425A1 (en) 2006-07-19
SI1680425T1 (sl) 2007-04-30
AR045810A1 (es) 2005-11-16
NO20061318L (no) 2006-04-21
PA8613301A1 (es) 2005-11-25
IL174281A0 (en) 2006-08-01
CR8288A (es) 2006-10-04
CO5690598A2 (es) 2006-10-31
PE20050433A1 (es) 2005-07-21
US20050090508A1 (en) 2005-04-28
MXPA06003206A (es) 2006-06-23
TW200512211A (en) 2005-04-01

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