TW200412936A - New amide compounds having MCH-antagonistic activity and medicaments comprising these compounds - Google Patents

New amide compounds having MCH-antagonistic activity and medicaments comprising these compounds Download PDF

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TW200412936A
TW200412936A TW092130313A TW92130313A TW200412936A TW 200412936 A TW200412936 A TW 200412936A TW 092130313 A TW092130313 A TW 092130313A TW 92130313 A TW92130313 A TW 92130313A TW 200412936 A TW200412936 A TW 200412936A
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Taiwan
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group
alkyl
phenyl
chloro
substituted
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TW092130313A
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Chinese (zh)
Inventor
Dirk Stenkamp
Stephan Georg Mueller
Gerald Juergen Roth
Thorsten Lehmann-Lintz
Klaus Rudolf
Lustenberger Philipp
Arndt Kirsten
R H Lotz Ralf
Lenter Martin
Wieland Heike-Andrea
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Boehringer Ingelheim Pharma
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Publication of TW200412936A publication Critical patent/TW200412936A/zh

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TW092130313A 2002-10-31 2003-10-30 New amide compounds having MCH-antagonistic activity and medicaments comprising these compounds TW200412936A (en)

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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
FR2866880A1 (fr) * 2004-02-27 2005-09-02 Oreal Para-phenylenediamine secondaire n-alkylaminee ortho-et/ou meta-substituee, composition de teinture des fibres keratiniques contenant une telle para-phenylenediamine, procedes mettant en oeuvre cette composition et utilisations
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
JP2006076990A (ja) * 2004-03-12 2006-03-23 Bayer Cropscience Ag 殺虫性ベンゼンジカルボキサミド類
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017934A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
BRPI0716579A2 (pt) 2006-08-25 2013-10-08 Boehringer Ingelheim Int Derivados de piridona com atividade antagonista ao mch e medicamentos que compreendem estes compostos
WO2008069611A1 (en) * 2006-12-08 2008-06-12 Korea Research Institute Of Chemical Technology N-phenylamide derivative, process for the preparation thereof, and composition for preventing or treating ischemic diseases comprising same
WO2008071646A1 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim International Gmbh New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds
AR073049A1 (es) * 2008-08-07 2010-10-13 Bayer Cropscience Sa Derivados fungicidas de oxialquilamida
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
EP2362731B1 (en) 2008-10-31 2016-04-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
US9079880B2 (en) * 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
EP2583965B1 (en) * 2010-07-15 2017-01-25 Takeda Pharmaceutical Company Limited Heterocyclic ring compound
SG192941A1 (en) 2011-02-25 2013-09-30 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
CA2842364A1 (en) * 2011-07-29 2013-02-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
ES2655645T3 (es) 2011-07-29 2018-02-21 Karyopharm Therapeutics, Inc. Moduladores de transporte nuclear que contienen hidrazida y usos de los mismos
CA2868484A1 (en) 2012-03-28 2013-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Salicylic acid derivatives useful as glucocerebrosidase activators
PL3404027T3 (pl) 2012-05-09 2020-09-21 Biogen Ma Inc. Modulatory transportu jądrowego i ich zastosowania
WO2014022528A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
JP2016516004A (ja) 2013-02-22 2016-06-02 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗糖尿病二環式化合物
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
WO2014144772A1 (en) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
LT3010892T (lt) 2013-06-21 2019-04-10 Karyopharm Therapeutics Inc. 1,2,4-triazolai kaip branduolio transporto moduliatoriai ir jų panaudojimas
DK3013796T3 (da) 2013-06-27 2020-03-16 Lg Chemical Ltd Biarylderivater som gpr120-agonister
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
DK3180331T3 (da) 2014-08-15 2022-09-12 Karyopharm Therapeutics Inc Polymorfer af selinexor
CN105439914B (zh) * 2014-09-17 2017-07-11 复旦大学 4‑氨酰基苯氧乙酰胺类化合物及其药物用途
CA2970011C (en) * 2014-12-24 2021-08-03 Lg Chem, Ltd. Biaryl derivative as gpr120 agonist
JP6533997B2 (ja) * 2014-12-26 2019-06-26 株式会社ヤクルト本社 Znf143阻害活性を有する化合物およびその利用
EP3397633A1 (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
MA43530A (fr) 2015-12-31 2018-11-07 Karyopharm Therapeutics Inc Modulateurs de transport nucléaire et leurs utilisations
JP6814814B2 (ja) 2016-03-17 2021-01-20 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Taarのアゴニストとしての活性を有する5−エチル−4−メチル−ピラゾール−3−カルボキサミド誘導体
WO2018098472A1 (en) 2016-11-28 2018-05-31 Karyopharm Therapeutics Inc. Crm1 inhibitors for treating epilepsy
WO2018106518A1 (en) 2016-12-06 2018-06-14 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
US20220315545A1 (en) 2019-07-10 2022-10-06 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-1,3-thiazolidin-4-ones
US20240174680A1 (en) 2021-01-29 2024-05-30 Cedilla Therapeutics, Inc. Cdk2 inhibitors and methods of using the same
US12053459B2 (en) 2021-06-26 2024-08-06 Cedilla Therapeutics, Inc. CDK2 inhibitors and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1100495A4 (en) * 1998-07-28 2002-09-25 Smithkline Beecham Corp PROPENAMIDES AS CCR5 MODULATORS
US7115750B1 (en) * 1999-09-20 2006-10-03 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonist
JP2004504303A (ja) * 2000-07-05 2004-02-12 シナプティック・ファーマスーティカル・コーポレーション 選択的メラニン凝集ホルモン−1(mch1)受容体アンタゴニストおよびその使用
US20030022891A1 (en) * 2000-12-01 2003-01-30 Anandan Palani MCH antagonists and their use in the treatment of obesity
AR036939A1 (es) * 2001-10-25 2004-10-13 Schering Corp Antagonistas de la hormona de concentracion de melanina (mch) composiciones farmaceuticas, un proceso para su elaboracion y el uso de dichos compuestos, solos o en combinacion, para la elaboracion de un medicamento para el tratamiento de obesidad

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AU2003285306A1 (en) 2004-05-25
PE20040785A1 (es) 2004-12-23
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AR041735A1 (es) 2005-05-26
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BR0315797A (pt) 2005-09-13
ECSP055765A (es) 2005-07-06
PL376256A1 (en) 2005-12-27
WO2004039764A1 (de) 2004-05-13
UY28051A1 (es) 2004-05-31
ES2327329T3 (es) 2009-10-28
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CA2504207C (en) 2012-10-02
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NO20050745L (no) 2005-05-23
KR20050065654A (ko) 2005-06-29
RS20050330A (sr) 2007-12-31
EA200500596A1 (ru) 2005-12-29
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EP1558567A1 (de) 2005-08-03
CA2504207A1 (en) 2004-05-13

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